Norman Arnheim - Publications

1968-1985 Stony Brook University, Stony Brook, NY, United States 
 1985- University of Southern California, Los Angeles, CA, United States 
Molecular Biology, Genetics, Neuroscience Biology

173 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Eboreime J, Choi SK, Yoon SR, Arnheim N, Calabrese P. Estimating Exceptionally Rare Germline and Somatic Mutation Frequencies via Next Generation Sequencing. Plos One. 11: e0158340. PMID 27341568 DOI: 10.1371/Journal.Pone.0158340  1
2016 Arnheim N, Calabrese P. Germline Stem Cell Competition, Mutation Hot Spots, Genetic Disorders, and Older Fathers. Annual Review of Genomics and Human Genetics. PMID 27070266 DOI: 10.1146/Annurev-Genom-083115-022656  1
2013 Shinde DN, Elmer DP, Calabrese P, Boulanger J, Arnheim N, Tiemann-Boege I. New evidence for positive selection helps explain the paternal age effect observed in achondroplasia. Human Molecular Genetics. 22: 4117-26. PMID 23740942 DOI: 10.1093/Hmg/Ddt260  1
2013 Yoon SR, Choi SK, Eboreime J, Gelb BD, Calabrese P, Arnheim N. Age-dependent germline mosaicism of the most common noonan syndrome mutation shows the signature of germline selection. American Journal of Human Genetics. 92: 917-26. PMID 23726368 DOI: 10.1016/J.Ajhg.2013.05.001  1
2012 Choi SK, Yoon SR, Calabrese P, Arnheim N. Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. Plos Genetics. 8: e1002420. PMID 22359510 DOI: 10.1371/Journal.Pgen.1002420  1
2011 Arnheim N, Calabrese P. Recurrent germline mutations in the FGFR2/3 genes, high mutation frequency, paternal skewing and age-dependence Monographs in Human Genetics. 19: 58-66. DOI: 10.1159/000318834  1
2009 Qin J, Subramanian J, Arnheim N. Detection of meiotic DNA breaks in mouse testicular germ cells. Methods in Molecular Biology (Clifton, N.J.). 557: 165-81. PMID 19799182 DOI: 10.1007/978-1-59745-527-5_11  1
2009 Tiemann-Boege I, Curtis C, Shinde DN, Goodman DB, Tavaré S, Arnheim N. Product length, dye choice, and detection chemistry in the bead-emulsion amplification of millions of single DNA molecules in parallel. Analytical Chemistry. 81: 5770-6. PMID 19601653 DOI: 10.1021/Ac900633Y  1
2009 Yoon SR, Qin J, Glaser RL, Jabs EW, Wexler NS, Sokol R, Arnheim N, Calabrese P. The ups and downs of mutation frequencies during aging can account for the Apert syndrome paternal age effect. Plos Genetics. 5: e1000558. PMID 19593369 DOI: 10.1371/Journal.Pgen.1000558  1
2009 Arnheim N, Calabrese P. Understanding what determines the frequency and pattern of human germline mutations. Nature Reviews. Genetics. 10: 478-88. PMID 19488047 DOI: 10.1038/Nrg2529  1
2008 Choi SK, Yoon SR, Calabrese P, Arnheim N. A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutations. Proceedings of the National Academy of Sciences of the United States of America. 105: 10143-8. PMID 18632557 DOI: 10.1073/Pnas.0801267105  1
2007 Arnheim N, Calabrese P, Tiemann-Boege I. Mammalian meiotic recombination hot spots. Annual Review of Genetics. 41: 369-99. PMID 18076329 DOI: 10.1146/Annurev.Genet.41.110306.130301  1
2007 Qin J, Calabrese P, Tiemann-Boege I, Shinde DN, Yoon SR, Gelfand D, Bauer K, Arnheim N. The molecular anatomy of spontaneous germline mutations in human testes. Plos Biology. 5: e224. PMID 17760502 DOI: 10.1371/Journal.Pbio.0050224  1
2007 Wyrobek AJ, Mulvihill JJ, Wassom JS, Malling HV, Shelby MD, Lewis SE, Witt KL, Preston RJ, Perreault SD, Allen JW, DeMarini DM, Woychik RP, Bishop JB, Anderson D, Arnheim N, et al. Assessing human germ-cell mutagenesis in the postgenome era: A celebration of the legacy of William Lawson (Bill) Russell Environmental and Molecular Mutagenesis. 48: 71-95. PMID 17295306 DOI: 10.1002/em.20284  1
2007 Andresen JM, Gayán J, Djoussé L, Roberts S, Brocklebank D, Cherny SS, Cardon LR, Gusella JF, MacDonald ME, Myers RH, Housman DE, Wexler NS. The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset. Annals of Human Genetics. 71: 295-301. PMID 17181545 DOI: 10.1111/J.1469-1809.2006.00335.X  1
2007 Clark VJ, Ptak SE, Tiemann I, Qian Y, Coop G, Stone AC, Przeworski M, Arnheim N, Di Rienzo A. Combining sperm typing and linkage disequilibrium analyses reveals differences in selective pressures or recombination rates across human populations. Genetics. 175: 795-804. PMID 17151245 DOI: 10.1534/Genetics.106.064964  1
2006 Wyrobek AJ, Eskenazi B, Young S, Arnheim N, Tiemann-Boege I, Jabs EW, Glaser RL, Pearson FS, Evenson D. Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in sperm. Proceedings of the National Academy of Sciences of the United States of America. 103: 9601-6. PMID 16766665 DOI: 10.1073/Pnas.0506468103  1
2006 Tiemann-Boege I, Calabrese P, Cochran DM, Sokol R, Arnheim N. High-resolution recombination patterns in a region of human chromosome 21 measured by sperm typing. Plos Genetics. 2: e70. PMID 16680198 DOI: 10.1371/Journal.Pgen.0020070  1
2006 Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, ... ... Arnheim N, et al. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Molecular and Cellular Biology. 26: 976-89. PMID 16428451 DOI: 10.1128/Mcb.26.3.976-989.2006  1
2005 Chen PC, Dudley S, Hagen W, Dizon D, Paxton L, Reichow D, Yoon SR, Yang K, Arnheim N, Liskay RM, Lipkin SM. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Cancer Research. 65: 8662-70. PMID 16204034 DOI: 10.1158/0008-5472.CAN-05-0742  1
2005 Subramanian J, Vijayakumar S, Tomkinson AE, Arnheim N. Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics. 171: 427-41. PMID 15965249 DOI: 10.1534/genetics.105.042861  1
2004 Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, ... ... Arnheim N, et al. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proceedings of the National Academy of Sciences of the United States of America. 101: 3498-503. PMID 14993615 DOI: 10.1073/Pnas.0308679101  1
2004 Qin J, Richardson LL, Jasin M, Handel MA, Arnheim N. Mouse strains with an active H2-Ea meiotic recombination hot spot exhibit increased levels of H2-Ea-specific DNA breaks in testicular germ cells. Molecular and Cellular Biology. 24: 1655-66. PMID 14749381 DOI: 10.1128/MCB.24.4.1655-1666.2004  1
2004 Brohede J, Arnheim N, Ellegren H. Single-Molecule Analysis of the Hypermutable Tetranucleotide Repeat Locus D21S1245 Through Sperm Genotyping: A Heterogeneous Pattern of Mutation but no Clear Male Age Effect Molecular Biology and Evolution. 21: 58-64. PMID 14530459 DOI: 10.1093/Molbev/Msg242  1
2003 Yoon SR, Dubeau L, de Young M, Wexler NS, Arnheim N. Huntington disease expansion mutations in humans can occur before meiosis is completed. Proceedings of the National Academy of Sciences of the United States of America. 100: 8834-8. PMID 12857955 DOI: 10.1073/pnas.1331390100  1
2003 Lai Y, Shinde D, Arnheim N, Sun F. The mutation process of microsatellites during the polymerase chain reaction. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 10: 143-55. PMID 12804088 DOI: 10.1089/106652703321825937  1
2003 Arnheim N, Calabrese P, Nordborg M. Hot and cold spots of recombination in the human genome: the reason we should find them and how this can be achieved. American Journal of Human Genetics. 73: 5-16. PMID 12772086 DOI: 10.1086/376419  1
2003 Nenguke T, Aladjem MI, Gusella JF, Wexler NS, Arnheim N. Candidate DNA replication initiation regions at human trinucleotide repeat disease loci. Human Molecular Genetics. 12: 1021-8. PMID 12700170 DOI: 10.1093/hmg/ddg111  1
2003 Shinde D, Lai Y, Sun F, Arnheim N. Taq DNA polymerase slippage mutation rates measured by PCR and quasi-likelihood analysis: (CA/GT)n and (A/T)n microsatellites. Nucleic Acids Research. 31: 974-80. PMID 12560493 DOI: 10.1093/nar/gkg178  1
2002 Lien S, Szyda J, Leeflang EP, Hubert R, Zhang L, Schmitt K, Arnheim N. Single-sperm typing. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. Unit 1.6. PMID 18428321 DOI: 10.1002/0471142905.hg0106s32  1
2002 Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proceedings of the National Academy of Sciences of the United States of America. 99: 14952-7. PMID 12397172 DOI: 10.1073/Pnas.232568699  1
2002 Qin J, Baker S, Te Riele H, Liskay RM, Arnheim N. Evidence for the lack of mismatch-repair directed antirecombination during mouse meiosis Journal of Heredity. 93: 201-205. PMID 12195036  1
2001 Pathak S, Choi SK, Arnheim N, Thompson ME. Hydroxylated quantum dots as luminescent probes for in situ hybridization. Journal of the American Chemical Society. 123: 4103-4. PMID 11457171 DOI: 10.1021/Ja0058334  1
2000 Han LL, Keller MP, Navidi W, Chance PF, Arnheim N. Unequal exchange at the Charcot-Marie-Tooth disease type 1A recombination hot-spot is not elevated above the genome average rate Human Molecular Genetics. 9: 1881-1889. PMID 10915777  1
2000 Guan T, Kehlenbach RH, Schirmer EC, Kehlenbach A, Fan F, Clurman BE, Arnheim N, Gerace L. Nup50, a nucleoplasmically oriented nucleoporin with a role in nuclear protein export. Molecular and Cellular Biology. 20: 5619-30. PMID 10891499 DOI: 10.1128/Mcb.20.15.5619-5630.2000  1
2000 Lien S, Szyda J, Schechinger B, Rappold G, Arnheim N. Evidence for heterogeneity in recombination in the human pseudoautosomal region: High resolution analysis by sperm typing and radiation-hybrid mapping American Journal of Human Genetics. 66: 557-566. PMID 10677316 DOI: 10.1086/302754  1
2000 Girardet A, McPeek MS, Leeflang EP, Munier F, Arnheim N, Claustres M, Pellestor F. Meiotic segregation analysis of RB1 alleles in retinoblastoma pedigrees by use of single-sperm typing. American Journal of Human Genetics. 66: 167-75. PMID 10631148 DOI: 10.1086/302715  1
1999 Fan F, Liu CP, Tavaré S, Arnheim N. Polymorphisms in the human DNA repair gene XPF Mutation Research - Mutation Research Genomics. 406: 115-120. PMID 10479728 DOI: 10.1016/S1383-5726(99)00008-4  1
1999 Grewal RP, Cancel G, Leeflang EP, Dürr A, McPeek MS, Draghinas D, Yao X, Stevanin G, Alnot MO, Brice A, Arnheim N. French Machado-Joseph disease patients do not exhibit gametic segregation distortion: a sperm typing analysis. Human Molecular Genetics. 8: 1779-84. PMID 10441343 DOI: 10.1093/Hmg/8.9.1779  1
1999 Yao X, Buermeyer AB, Narayanan L, Tran D, Baker SM, Prolla TA, Glazer PM, Liskay RM, Arnheim N. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6850-5. PMID 10359802 DOI: 10.1073/pnas.96.12.6850  1
1999 Girardet A, Lien S, Leeflang EP, Beaufrère L, Tuffery S, Munier F, Arnheim N, Claustres M, Pellestor F. Direct estimation of the recombination frequency between the RB1 gene and two closely linked microsatellites using sperm typing European Journal of Human Genetics. 7: 239-242. PMID 10196709  1
1999 Lien S, Cockett NE, Klungland H, Arnheim N, Georges M, Gomez-Raya L. High-resolution gametic map of the sheep callipyge region: Linkage heterogeneity among rams detected by sperm typing Animal Genetics. 30: 42-46. PMID 10050282 DOI: 10.1046/j.1365-2052.1999.00430.x  1
1999 Moore H, Greenwell PW, Liu CP, Arnheim N, Petes TD. Triplet repeats form secondary structures that escape DNA repair in yeast Proceedings of the National Academy of Sciences of the United States of America. 96: 1504-1509. PMID 9990053 DOI: 10.1073/Pnas.96.4.1504  1
1999 Leeflang EP, Tavaré S, Marjoram P, Neal CO, Srinidhi J, MacFarlane H, MacDonald ME, Gusella JF, de Young M, Wexler NS, Arnheim N. Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism. Human Molecular Genetics. 8: 173-83. PMID 9931325 DOI: 10.1093/Hmg/8.2.173  1
1999 Navidi W, Arnheim N. Combining Data from Polymerase Chain Reaction DNA Typing Experiments: Applications to Sperm Typing Data Journal of the American Statistical Association. 94: 726-733.  1
1998 Grewal RP, Leeflang EP, Zhang L, Arnheim N. The mutation properties of spinal and bulbar muscular atrophy disease alleles Neurogenetics. 1: 249-252. PMID 10732798  1
1998 Korobova O, Lane PW, Perry J, Palmer S, Ashworth A, Davisson MT, Arnheim N. Patchy fur, a mouse coat mutation associated with X-Y nondisjunction, maps to the pseudoautosomal boundary region Genomics. 54: 556-559. PMID 9878259 DOI: 10.1006/geno.1998.5528  1
1998 Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, MacDonald ME, Zipursky SL. Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons. Neuron. 21: 633-42. PMID 9768849 DOI: 10.1016/S0896-6273(00)80573-5  1
1998 Prolla TA, Baker SM, Harris AC, Tsao JL, Yao X, Bronner CE, Zheng B, Gordon M, Reneker J, Arnheim N, Shibata D, Bradley A, Liskay RM. Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nature Genetics. 18: 276-9. PMID 9500552 DOI: 10.1038/Ng0398-276  1
1998 Xu G, Sze SH, Liu CP, Pevzner PA, Arnheim N. Gene hunting without sequencing genomic clones: finding exon boundaries in cDNAs. Genomics. 47: 171-9. PMID 9479489 DOI: 10.1006/Geno.1997.5072  1
1997 Sun F, Benson G, Arnheim N, Waterman M. Pooling strategies for establishing physical genome maps using FISH Journal of Computational Biology. 4: 467-486. PMID 9385540  1
1997 Kunst CB, Leeflang EP, Iber JC, Arnheim N, Warren ST. The effect of FMR1 CGG repeat interruptions on mutation frequency as measured by sperm typing Journal of Medical Genetics. 34: 627-631. PMID 9279752  1
1997 Arnheim N, Shibata D. DNA mismatch repair in mammals: Role in disease and meiosis Current Opinion in Genetics and Development. 7: 364-370. PMID 9229112 DOI: 10.1016/S0959-437X(97)80150-5  1
1997 Fan F, Liu CP, Korobova O, Heyting C, Offenberg HH, Trump G, Arnheim N. cDNA cloning and characterization of Npap60: A novel rat nuclear pore- associated protein with an unusual subcellular localization during male germ cell differentiation Genomics. 40: 444-453. PMID 9073512 DOI: 10.1006/geno.1996.4557  1
1996 Soong NW, Dang MH, Hinton DR, Arnheim N. Mitochondrial DNA deletions are rare in the free radical-rich retinal environment. Neurobiology of Aging. 17: 827-31. PMID 9363792 DOI: 10.1016/S0197-4580(96)00163-7  1
1996 Soong NW, Arnheim N. [36] Detection and quantification of mitochondrial DNA deletions Methods in Enzymology. 264: 421-423. PMID 8965714 DOI: 10.1016/S0076-6879(96)64038-5  1
1996 Yu J, Lazzeroni L, Qin J, Huang MM, Navidi W, Erlich H, Arnheim N. Individual variation in recombination among human males American Journal of Human Genetics. 59: 1186-1192. PMID 8940263  1
1996 Leeflang EP, McPeek MS, Arnheim N. Analysis of meiotic segregation, using single-sperm typing: meiotic drive at the myotonic dystrophy locus. American Journal of Human Genetics. 59: 896-904. PMID 8808606  1
1996 Shenkar R, Navidi W, Tavaré S, Dang MH, Chomyn A, Attardi G, Cortopassi G, Arnheim N. The mutation rate of the human mtDNA deletion mtDNA4977. American Journal of Human Genetics. 59: 772-80. PMID 8808591  1
1996 Baker SM, Plug AW, Prolla TA, Bronner CE, Harris AC, Yao X, Christie DM, Monell C, Arnheim N, Bradley A, Ashley T, Liskay RM. Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nature Genetics. 13: 336-42. PMID 8673133 DOI: 10.1038/ng0796-336  1
1996 Petruska J, Arnheim N, Goodman MF. Stability of intrastrand hairpin structures formed by the CAG/CTG class of DNA triplet repeats associated with neurological diseases Nucleic Acids Research. 24: 1992-1998. PMID 8668527 DOI: 10.1093/Nar/24.11.1992  1
1995 Huang MM, Erlich HA, Goodman MF, Arnheim N. Analysis of mutational changes at the HLA locus in single human sperm Human Mutation. 6: 303-310. PMID 8680404 DOI: 10.1002/humu.1380060404  1
1995 Leeflang EP, Zhang L, Tavaré S, Hubert R, Srinidhi J, MacDonald ME, Myers RH, de Young M, Wexler NS, Gusella JF. Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum. Human Molecular Genetics. 4: 1519-26. PMID 8541834 DOI: 10.1093/Hmg/4.9.1519  1
1995 Zhang L, Fischbeck KH, Arnheim N. CAG repeat length variation in sperm from a patient with Kennedy's disease. Human Molecular Genetics. 4: 303-5. PMID 7757084 DOI: 10.1093/hmg/4.2.303  1
1995 Zangenberg G, Huang MM, Arnheim N, Erlich H. New HLA–DPB1 alleles generated by interallelic gene conversion detected by analysis of sperm Nature Genetics. 10: 407-414. PMID 7670490 DOI: 10.1038/ng0895-407  1
1995 Sun F, Arnheim N, Waterman MS. Whole genome amplification of single cells: Mathematical analysis of PEP and tagged PCR Nucleic Acids Research. 23: 3034-3040. PMID 7659528 DOI: 10.1093/nar/23.15.3034  1
1995 Baker SM, Bronner CE, Zhang L, Plug AW, Robatzek M, Warren G, Elliott EA, Yu J, Ashley T, Arnheim N, Flavell RA, Liskay RM. Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. Cell. 82: 309-19. PMID 7628019 DOI: 10.1016/0092-8674(95)90318-6  1
1995 Soong NW, Arnheim N. [8] Quantitative PCR: Analysis of rare mitochondrial DNA mutations in central nervous system tissues Methods in Neurosciences. 26: 105-128. DOI: 10.1016/S1043-9471(06)80086-8  1
1994 Lazzeroni LC, Arnheim N, Schmitt K, Lange K. Multipoint mapping calculations for sperm-typing data American Journal of Human Genetics. 55: 431-436. PMID 8079987  1
1994 Schmitt K, Lazzeroni LC, Foote S, Vollrath D, Fisher EMC, Goradia TM, Lange K, Page DC, Arnheim N. Multipoint linkage map of the human pseudoautosomal region, based on single-sperm typing: Do double crossovers occur during male meiosis? American Journal of Human Genetics. 55: 423-430. PMID 8079986  1
1994 Zhang L, Leeflang EP, Yu J, Arnheim N. Studying human mutations by sperm typing: Instability of CAG trinucleotide repeats in the human androgen receptor gene Nature Genetics. 7: 531-535. PMID 7951325 DOI: 10.1038/ng0894-531  1
1994 Hubert R, Macdonald M, Gusella J, Arnheim N. High resolution localization of recombination hot spots using sperm typing Nature Genetics. 7: 420-424. PMID 7920662 DOI: 10.1038/Ng0794-420  1
1994 Ling X, Arnheim N. Cloning and identification of the pig ribosomal gene promoter Gene. 150: 375-379. PMID 7821810 DOI: 10.1016/0378-1119(94)90456-1  1
1994 Schmitt K, Arnheim N. Genetic recombination analysis using sperm typing Genetic Engineering. 16: 157-165. PMID 7765195  1
1994 Verlinsky Y, Handyside A, Grifo J, Munne S, Cohen J, Liebers I, Levinson G, Arnheim N, Hughes M, Delhanty J, Harper J, Mathews C, Kuliev A, Simpson JL, Monk M, et al. Preimplantation diagnosis of genetic and chromosomal disorders Journal of Assisted Reproduction and Genetics. 11: 236-243. PMID 7711387 DOI: 10.1007/BF02214343  1
1994 Navidi W, Arnheim N. Analysis of genetic data from the polymerase chain reaction Statistical Science. 9: 320-333. DOI: 10.1214/ss/1177010379  1
1994 Arnheim N. Genetic analysis by single cell typing Animal Biotechnology. 5: 83-88. DOI: 10.1080/10495399409525809  1
1993 Ling X, Shenkar R, Sakai D, Arnheim N. The mouse Eb meiotic recombination hotspot contains a tissue-specific transcriptional enhancer Immunogenetics. 37: 331-336. PMID 8428766 DOI: 10.1007/BF00216797  1
1993 Arnheim N, Boice J, Cox R, Gould M, Hall E, Knudson A, Mohrenweiser H, Sinclair W, Stanbridge E, Ullrich R, Ward J, Weinstein H, Karaoglou A, Galas D, Smith D, et al. Report on a workshop to examine methods to arrive at risk estimates for radiation-induced cancer in the human based on laboratory data Radiation Research. 135: 434-437. PMID 8378537 DOI: 10.2307/3578886  1
1993 Schmitt K, Vollralh D, Foote S, Fisher EMC, Page DC, Arnheim N. Four PCR-based polymorphisms in the pseudoautosomal region of the human X and Y chromosomes Human Molecular Genetics. 2: 1978. PMID 8281166 DOI: 10.1093/Hmg/2.11.1978  1
1992 Navidi W, Arnheim N, Waterman MS. A multiple-tubes approach for accurate genotyping of very small DNA samples by using PCR: Statistical considerations American Journal of Human Genetics. 50: 347-359. PMID 1734715  1
1992 Cui X, Gerwin J, Navidi W, Li H, Kuehn M, Arnheim N. Gene-centromere linkage mapping by PCR analysis of individual oocytes Genomics. 13: 713-717. PMID 1639398 DOI: 10.1016/0888-7543(92)90146-J  1
1992 Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N. Whole genome amplification from a single cell: Implications for genetic analysis Proceedings of the National Academy of Sciences of the United States of America. 89: 5847-5851. PMID 1631067 DOI: 10.1073/pnas.89.13.5847  1
1992 Navidi W, Arnheim N. Using PCR in preimplantation genetic disease diagnosis Human Reproduction. 7: 288. PMID 1577947  1
1992 Lewin HA, Schmitt K, Hubert R, van Eijk MJT, Arnheim N. Close linkage between bovine prolactin and BoLA-DRB3 genes: Genetic mapping in cattle by single sperm typing Genomics. 13: 44-48. PMID 1577492 DOI: 10.1016/0888-7543(92)90200-C  1
1992 Cortopassi GA, Shibata D, Soong NW, Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues Proceedings of the National Academy of Sciences of the United States of America. 89: 7370-7374. PMID 1502147  1
1992 Erlich HA, Arnheim N. Genetic analysis using the polymerase chain reaction Annual Review of Genetics. 26: 479-506. PMID 1482122  1
1992 Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. 1985. Biotechnology (Reading, Mass.). 24: 476-80. PMID 1422056  1
1992 Hubert R, Weber JL, Schmitt K, Zhang L, Arnheim N. A new source of polymorphic DNA markers for sperm typing: Analysis of microsatellite repeats in single cells American Journal of Human Genetics. 51: 985-991. PMID 1415267  1
1992 Huang Mm, Arnheim N, Goodman MF. Extension of base mispairs by Taq DNA polymerase: Implications for single nucleotide discrimination in PCR Nucleic Acids Research. 20: 4567-4573. PMID 1408758 DOI: 10.1093/nar/20.17.4567  1
1992 Arnheim N, Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues Mutation Research Dnaging. 275: 157-167. PMID 1383758 DOI: 10.1016/0921-8734(92)90020-P  1
1992 Arnheim N, Erlich H. Polymerase chain reaction strategy Annual Review of Biochemistry. 61: 131-156. PMID 1379788  1
1992 Creighton S, Huang MM, Cai H, Arnheim N, Goodman MF. Base mispair extension kinetics. Binding of avian myeloblastosis reverse transcriptase to matched and mismatched base pair termini Journal of Biological Chemistry. 267: 2633-2639. PMID 1370828  1
1992 Hubert R, Stanton VP, Aburatani H, Warren J, Li H, Housman DE, Arnheim N. Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3. Genomics. 12: 683-7. PMID 1349296 DOI: 10.1016/0888-7543(92)90294-3  1
1992 Soong NW, Hinton DR, Cortopassi G, Arnheim N. Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature Genetics. 2: 318-23. PMID 1303287 DOI: 10.1038/Ng1292-318  1
1992 Arnheim N. Preimplantation genetic diagnosis-a rolling stone gathers no moss! Human Reproduction. 7: 1481. PMID 1291582  1
1992 Arnheim N. Genetic Mapping and Preimplantation Diagnosis in Agriculturally Important Species using Single Cell PCR Animal Biotechnology. 3: 55-65. DOI: 10.1080/10495399209525762  1
1992 Cortopassi GA, Arnheim N. Using the polymerase chain reaction to estimate mutation frequencies and rates in human cells Mutation Research - Reviews in Mutation Research. 277: 239-249. DOI: 10.1016/0165-1110(92)90046-C  1
1992 Navidi W, Arnheim N. Letter to the editor Human Reproduction. 7: 288.  1
1991 Li H, Cui X, Arnheim N. Eliminating primers from completed polymerase chain reactions with exonuclease VII Nucleic Acids Research. 19: 3139-3141. PMID 2057368 DOI: 10.1093/nar/19.11.3139  1
1991 Shenkar R, Shen M, Arnheim N. DNase I-hypersensitive sites and transcription factor-binding motifs within the mouse Eβ meiotic recombination hot spot Molecular and Cellular Biology. 11: 1813-1819. PMID 1900917  1
1991 Arnheim N, Li H, Cui X. Genetic mapping by single sperm typing Animal Genetics. 22: 105-115. PMID 1892244  1
1991 Goradia TM, Stanton VP, Cui XF, Aburatani H, Li HH, Lange K, Housman DE, Arnheim N. Ordering three DNA polymorphisms on human chromosome 3 by sperm typing. Genomics. 10: 748-55. PMID 1679751 DOI: 10.1016/0888-7543(91)90459-R  1
1991 Li H, Cui X, Arnheim N. Analysis of DNA sequence variation in single cells Methods. 2: 49-59. DOI: 10.1016/S1046-2023(05)80125-2  1
1990 Shibata D, Almoguera C, Forrester K, Dunitz J, Martin SE, Cosgrove MM, Perucho M, Arnheim N. Detection of c-K-ras mutations in fine needle aspirates from human pancreatic adenocarcinomas. Cancer Research. 50: 1279-83. PMID 2404591  1
1990 Arnheim N. The possible role of Z DNA in chromosomal translocations Cancer Cells. 2: 121-122. PMID 2390418  1
1990 Arnheim N, Li H, Cui X. PCR analysis of DNA sequences in single cells: Single sperm gene mapping and genetic disease diagnosis Genomics. 8: 415-419. PMID 2286370 DOI: 10.1016/0888-7543(90)90026-Q  1
1990 Cortopassi GA, Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older humans Nucleic Acids Research. 18: 6927-6933. PMID 2263455 DOI: 10.1093/nar/18.23.6927  1
1990 Li HH, Cui XF, Arnheim N. Analysis of DNA sequences in individual gametes: application to human genetic mapping Progress in Clinical and Biological Research. 340: 207-211. PMID 2199979  1
1990 Li H, Cui X, Arnheim N. Direct electrophoretic detection of the allelic state of single DNA molecules in human sperm by using the polymerase chain reaction Proceedings of the National Academy of Sciences of the United States of America. 87: 4580-4584. PMID 1972276 DOI: 10.1073/pnas.87.12.4580  1
1990 Arnheim N. The polymerase chain reaction Genetic Engineering. 12: 115-137. PMID 1369998 DOI: 10.1016/0168-9525(89)90073-5  1
1990 Arnheim N. Dating PCR Bio/Technology. 8: 357. PMID 1366463 DOI: 10.1038/nbt0490-357a  1
1989 Shibata D, Brynes RK, Nathwani B, Kwok S, Sninsky J, Arnheim N. Human immunodeficiency viral DNA is readily found in lymph node biopsies from seropositive individuals. Analysis of fixed tissue using the polymerase chain reaction American Journal of Pathology. 135: 697-702. PMID 2679114  1
1989 Hemsley A, Arnheim N, Toney MD, Cortopassi G, Galas DJ. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucleic Acids Research. 17: 6545-51. PMID 2674899 DOI: 10.1093/Nar/17.16.6545  1
1989 Cui X, Li H, Goradia TM, Lange K, Kazazian HH, Galas D, Arnheim N. Single-sperm typing: Determination of genetic distance between the (G)γ-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers Proceedings of the National Academy of Sciences of the United States of America. 86: 9389-9393. PMID 2574460 DOI: 10.1073/pnas.86.23.9389  1
1989 Boehnke M, Arnheim N, Li H, Collins FS. Fine-structure genetic mapping of human chromosomes using the polymerase chain reaction on single sperm: Experimental design considerations American Journal of Human Genetics. 45: 21-32. PMID 2568090  1
1989 Shibata D, Cosgrove M, Arnheim N, Martin WJ, Martin SE. Detection of human papillomavirus DNA in fine-needle aspirations of metastatic squamous-cell carcinoma of the uterine cervix using the polymerase chain reaction. Diagnostic Cytopathology. 5: 40-3. PMID 2541988 DOI: 10.1002/dc.2840050109  1
1989 Kiyabu MT, Shibata D, Arnheim N, Martin WJ, Fitzgibbons PL. Detection of human papillomavirus in formalin-fixed, invasive squamous carcinomas using the polymerase chain reaction. The American Journal of Surgical Pathology. 13: 221-4. PMID 2537583 DOI: 10.1097/00000478-198903000-00007  1
1988 Li H, Gyllensten UB, Cui X, Saiki RK, Erlich HA, Arnheim N. Amplification and analysis of DNA sequences in single human sperm and diploid cells Nature. 335: 414-417. PMID 3419517  1
1988 Arnheim N, Erlich HA. Commercial uses of recombinant DNA technology in human genetic disease Progress in Medical Genetics. 7: 195-219. PMID 3277255  1
1988 Cohn VH, Sears D, Hess M, Spielman RS, Arnheim N, Weiner LP. Determination of RFLPs linked to multiple sclerosis susceptibility Annals of the New York Academy of Sciences. 540: 269-270. PMID 2905119  1
1988 Seperack P, Slatkin M, Arnheim N. Linkage disequilibrium in human ribosomal genes: implications for multigene family evolution. Genetics. 119: 943-9. PMID 2900795  1
1988 Arnheim N. New technologies for studying human genetic variation Basic Life Sciences. 43: 37-44. PMID 2896495  1
1988 Shibata D, Martin WJ, Appleman MD, Causey DM, Leedom JM, Arnheim N. Detection of cytomegalovirus DNA in peripheral blood of patients infected with human immunodeficiency virus. The Journal of Infectious Diseases. 158: 1185-92. PMID 2848898 DOI: 10.1093/infdis/158.6.1185  1
1988 Shibata D, Fu YS, Gupta JW, Shah KV, Arnheim N, Martin WJ. Detection of human papillomavirus in normal and dysplastic tissue by the polymerase chain reaction. Laboratory Investigation; a Journal of Technical Methods and Pathology. 59: 555-9. PMID 2845193  1
1988 Shibata D, Martin WJ, Arnheim N. Analysis of DNA sequences in forty-year-old paraffin-embedded thin-tissue sections: a bridge between molecular biology and classical histology. Cancer Research. 48: 4564-6. PMID 2840197  1
1988 Shibata DK, Arnheim N, Martin WJ. Detection of human papilloma virus in paraffin-embedded tissue using the polymerase chain reaction. The Journal of Experimental Medicine. 167: 225-30. PMID 2826637 DOI: 10.1084/Jem.167.1.225  1
1988 Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 53: 549-54. PMID 2453289 DOI: 10.1016/0092-8674(88)90571-5  1
1987 Embury SH, Scharf SJ, Saiki RK, Gholson MA, Golbus M, Arnheim N, Erlich HA. Rapid prenatal diagnosis of sickle cell anemia by a new method of DNA analysis New England Journal of Medicine. 316: 656-661. PMID 3821796  1
1987 Wrischnik LA, Higuchi RG, Stoneking M, Erlich HA, Arnheim N, Wilson AC. Length mutations in human mitochondrial DNA: direct sequencing of enzymatically amplified DNA. Nucleic Acids Research. 15: 529-42. PMID 2881260 DOI: 10.1093/Nar/15.2.529  1
1986 Treco D, Arnheim N. The evolutionarily conserved repetitive sequence d(TG.AC)n promotes reciprocal exchange and generates unusual recombinant tetrads during yeast meiosis Molecular and Cellular Biology. 6: 3934-3947. PMID 3540602  1
1986 Wong G, Arnheim N, Clark R, McCormick F, Aldwin L, Nitecki D, McCabe P, Innis M. Detection of activated mr21,000 protein, the product of ras oncogenes, using antibodies with specificity for amino acid 12 Cancer Research. 46: 6029-6033. PMID 3490906  1
1985 Clark R, Wong G, Arnheim N, Nitecki D, McCormick F. Antibodies specific for amino acid 12 of the ras oncogene product inhibit GTP binding Proceedings of the National Academy of Sciences of the United States of America. 82: 5280-5284. PMID 3927300 DOI: 10.1073/Pnas.82.16.5280  1
1985 Treco D, Thomas B, Arnheim N. Recombination hot spot in the human β-globin gene cluster: Meiotic recombination of human DNA fragments in Saccharomyes cerevisiae Molecular and Cellular Biology. 5: 2029-2038. PMID 3018546  1
1985 Saiki RK, Scharf S, Faloona F, Mullis KB, Horn GT, Erlich HA, Arnheim N. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (New York, N.Y.). 230: 1350-4. PMID 2999980 DOI: 10.1126/Science.2999980  1
1985 Arnheim N, Strange C, Erlich H. Use of pooled DNA samples to detect linkage disequilibrium of polymorphic restriction fragments and human disease: Studies of the HLA class II loci Proceedings of the National Academy of Sciences of the United States of America. 82: 6970-6974. PMID 2995996  1
1985 Feramisco JR, Clark R, Wong G, Arnheim N, Milley R, McCormick F. Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein Nature. 314: 639-642. PMID 2581140 DOI: 10.1038/314639a0  1
1985 Saiki RK, Arnheim N, Erlich HA. A novel method for the detection of polymorphic restriction sites by cleavage of oligonucleotide probes: Application to sickle-cell anemia Bio/Technology. 3: 1008-1012. DOI: 10.1038/nbt1185-1008  1
1984 Miesfeld R, Arnheim N. Species-specific rDNA transcription is due to promoter-specific binding factors Molecular and Cellular Biology. 4: 221-227. PMID 6700588  1
1984 Miesfeld R, Sollner-Webb B, Croce C, Arnheim N. The absence of a human-specific ribosomal DNA transcription factor leads to nucleolar dominance in mouse greater than human hybrid cells. Molecular and Cellular Biology. 4: 1306-12. PMID 6095060  1
1983 Brownell E, Krystal M, Arnheim N. Structure and evolution of human and African ape rDNA pseudogenes. Molecular Biology and Evolution. 1: 29-37. PMID 6599961  1
1983 Kuehn M, Arnheim N. Nucleotide sequence of the genetically labile repeated elements 5′ to the origin of mouse rRNA transcription Nucleic Acids Research. 11: 211-224. PMID 6306564 DOI: 10.1093/nar/11.1.211  1
1982 Arnheim N, Treco D, Taylor B, Eicher EM. Distribution of ribosomal gene length variants among mouse chromosomes Proceedings of the National Academy of Sciences of the United States of America. 79: 4677-4680. PMID 6956886  1
1982 Miesfeld R, Arnheim N. Identification of the in vivo and in vitro origin of transcription in human rDNA Nucleic Acids Research. 10: 3933-3939. PMID 6287426 DOI: 10.1093/nar/10.13.3933  1
1981 Marcu KB, Arnheim N, Banerji J, Penncavage NA, Seperack P, Lang R, Miesfeld R, Harris L, Greenberg R. Studies on the nature and germ-line stability of DNA sequences flanking the mouse immunoglobulin heavy-chain constant-region genes Cold Spring Harbor Symposia On Quantitative Biology. 45: 899-911. PMID 6790222  1
1981 Krystal M, D'Eustachio P, Ruddle FH, Arnheim N. Human nucleolus organizers on nonhomologous chromosomes can share the same ribosomal gene variants Proceedings of the National Academy of Sciences of the United States of America. 78: 5744-5748. PMID 6272316  1
1980 Marcu KB, Banerji J, Penncavage NA, Lang R, Arnheim N. 5' Flanking region of immunoglobulin heavy chain constant region genes displays length heterogeneity in germlines of inbred mouse strains Cell. 22: 187-196. PMID 6775817 DOI: 10.1016/0092-8674(80)90167-1  1
1980 Arnheim N, Seperack P, Banerji J, Lang RB, Miesfeld R, Marcu KB. Mouse rDNA nontranscribed spacer sequences are found flanking immunoglobulin CH genes and elsewhere throughout the genome. Cell. 22: 179-85. PMID 6775816 DOI: 10.1016/0092-8674(80)90166-X  1
1980 Arnheim N, Krystal M, Schmickel R, Wilson G, Ryder O, Zimmer E. Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes Proceedings of the National Academy of Sciences of the United States of America. 77: 7323-7327. PMID 6261251 DOI: 10.1073/Pnas.77.12.7323  1
1980 Castora FJ, Arnheim N, Simpson MV. Mitochondrial DNA polymorphism: evidence that variants detected by restriction enzymes differ in nucleotide sequence rather than in methylation Proceedings of the National Academy of Sciences of the United States of America. 77: 6415-6419. PMID 6256736  1
1980 Heller R, Arnheim N. Structure and organization of the highly repeated and interspersed 1.3 kb EcoRI - Bg1II sequence family in mice Nucleic Acids Research. 8: 5031-5042. PMID 6255440 DOI: 10.1093/nar/8.21.5031  1
1979 Young JP, Koehn RK, Arnheim N. Biochemical characterization of "LAP," a polymorphic aminopeptidase from the blue mussel, Mytilus edulis. Biochemical Genetics. 17: 305-23. PMID 486074 DOI: 10.1007/Bf00498971  1
1979 Arnheim N, Kuehn M. The genetic behaviour of a cloned mouse ribosomal DNA segment mimics mouse ribosomal gene evolution Journal of Molecular Biology. 134: 743-763. PMID 231673 DOI: 10.1016/0022-2836(79)90483-2  1
1979 Arnheim N. Characterization of mouse ribosomal gene fragments purified by molecular cloning Gene. 7: 83-96. PMID 159852 DOI: 10.1016/0378-1119(79)90025-8  1
1978 Krystal M, Arnheim N. Length heterogeneity in a region of the human ribosomal gene spacer is not accompanied by extensive population polymorphism Journal of Molecular Biology. 126: 91-104. PMID 739545 DOI: 10.1016/0022-2836(78)90281-4  1
1978 Strobel E, Pelling C, Arnheim N. Incomplete dosage compensation in an evolving Drosophila sex chromosome Proceedings of the National Academy of Sciences of the United States of America. 75: 931-935. PMID 273254  1
1977 Arnheim N, Southern EM. Heterogeneity of the ribosomal genes in mice and men. Cell. 11: 363-70. PMID 560912 DOI: 10.1016/0092-8674(77)90053-8  1
1976 Arnheim N, MacIntyre R. Preparation of specific antisera to Drosophila acid phosphatase without rigorous protein purification. Biochemical Genetics. 14: 237-43. PMID 822833 DOI: 10.1007/BF00484763  1
1974 Arnheim N, Millett F, Raftery MA. Nuclear magnetic resonance and ultraviolet difference spectral studies of the binding properties of turkey egg white lysozyme. Consequences of the replacement of ASP 101 by glycine Archives of Biochemistry and Biophysics. 165: 281-287. PMID 4474836 DOI: 10.1016/0003-9861(74)90166-0  1
1974 Prager EM, Wilson AC, Arnheim N. Widespread distribution of lysozyme g in egg white of birds. The Journal of Biological Chemistry. 249: 7295-7. PMID 4215815  1
1974 Hindenburg A, Spitznagel J, Arnheim N. Isozymes of lysozyme in leukocytes and egg white: evidence for the species specific control of egg white lysozyme synthesis Proceedings of the National Academy of Sciences of the United States of America. 71: 1653-1657. PMID 4209557  1
1973 Inouye M, Arnheim N, Sternglanz R. Bacteriophage T7 lysozyme is an N acetylmuramyl L alanine amidase Journal of Biological Chemistry. 248: 7247-7252. PMID 4582731  1
1973 Arnheim N, Inouye M, Law L, Laudin A. Chemical studies on the enzymatic specificity of goose egg white lysozyme Journal of Biological Chemistry. 248: 233-236. PMID 4571225  1
1973 Arnheim N, Hindenbug A, Begg GS, Morgan FJ. Multiple genes for lysozyme in birds: studies on black swan egg white lysozymes Journal of Biological Chemistry. 248: 8036-8042. PMID 4201778 DOI: 10.1016/0003-9861(70)90185-2  1
1972 Prager EM, Arnheim N, Mross GA, Wilson AC. Amino acid sequence studies on bobwhite quail egg white lysozyme. The Journal of Biological Chemistry. 247: 2905-16. PMID 4112539  1
1971 Arnheim N, Sobel J, Canfield R. Immunochemical resemblance between human leukemia and hen egg-white lysozyme and their reduced carboxymethyl derivatives Journal of Molecular Biology. 61: 237-250. PMID 5004355 DOI: 10.1016/0022-2836(71)90220-8  1
1969 Arnheim N, Taylor CE. Non-darwinian evolution: Consequences for neutral allelic variation Nature. 223: 900-903. PMID 5803391 DOI: 10.1038/223900a0  1
1969 Arnheim N, Prager EM, Wilson AC. Immunological prediction of sequence differences among proteins. Chemical comparison of chicken, quail, and phesant lysozymes. The Journal of Biological Chemistry. 244: 2085-94. PMID 4889463  1
1968 Wilson AC, Arnheim N. A small molecule in hagfish tissues, possibly related to the cardiac agent, eptatretin. Comparative Biochemistry and Physiology. 25: 359-62. PMID 5657214 DOI: 10.1016/0010-406X(68)90945-6  0.36
1968 Wilson AC, Arnheim N. A small molecule in hagfish tissues, possibly related to the cardiac agent, eptatretin Comparative Biochemistry and Physiology. 25: 359-362.  1
1967 Arnheim N. The regional effects of two mutants in Drosophila analyzed by means of mosaics Genetics. 56: 253-263. PMID 6040494  1
1967 Arnheim N, Cocks GT, Wilson AC. Molecular size of hagfish muscle lactate dehydrogenase Science. 157: 568-569. PMID 6028922 DOI: 10.1126/Science.157.3788.568  1
1966 Tokunaga C, Arnheim N. Age dependence of the locations of x-ray induced somatic crossing over in Drosophila Genetics. 54: 267-276. PMID 5961482  1
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