| Year |
Citation |
Score |
| 2023 |
Benramdane S, De Loose J, Filippi N, Espadinha M, Beyens O, Rymenant YV, Dirkx L, Bozdag M, Feijens PB, Augustyns K, Caljon G, De Winter H, De Meester I, Van der Veken P. Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin. Journal of Medicinal Chemistry. PMID 37721854 DOI: 10.1021/acs.jmedchem.3c00609 |
0.333 |
|
| 2020 |
Balabon O, Pitta E, Rogacki MK, Meiler E, Casanueva R, Guijarro L, Huss S, Lopez-Roman EM, Santos-Villarejo Á, Augustyns K, Ballell L, Aguirre DB, Bates RH, Cunningham F, Cacho M, et al. Optimization of Hydantoins as Potent Antimycobacterial Decaprenylphosphoryl-β-d-Ribose Oxidase (DprE1) Inhibitors. Journal of Medicinal Chemistry. PMID 32342688 DOI: 10.1021/Acs.Jmedchem.0C00107 |
0.392 |
|
| 2020 |
G Salado I, Singh AK, Moreno-Cinos C, Sakaine G, Siderius M, Van der Veken P, Matheeussen A, Van der Meer T, Sadek P, Gul S, Maes L, Sterk GJ, Leurs R, Brown DG, Augustyns K. Lead optimization of phthalazinone phosphodiesterase inhibitors as novel antitrypanosomal compounds. Journal of Medicinal Chemistry. PMID 32196340 DOI: 10.1021/Acs.Jmedchem.9B00985 |
0.383 |
|
| 2020 |
Martens S, Hofmans S, Declercq W, Augustyns K, Vandenabeele P. Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs. Trends in Pharmacological Sciences. 41: 209-224. PMID 32035657 DOI: 10.1016/J.Tips.2020.01.002 |
0.322 |
|
| 2020 |
Plaeke P, De Man J, Smet A, De Meester I, Augustyns K, Jorens P, Hubens G, De Winter BY. 895 REDUCTION OF INTRAPERITONEAL ADHESIOGENESIS BY PROTEASE INHIBITORS IN A CECAL LIGATION AND PUNCTURE MODEL OF SEPSIS AND PERITONITIS. Gastroenterology. 158: S-1537. DOI: 10.1016/S0016-5085(20)34520-0 |
0.358 |
|
| 2019 |
De Araújo JS, da Silva PB, Batista MM, Peres RB, Cardoso-Santos C, Kalejaiye TD, Munday JC, De Heuvel E, Sterk GJ, Augustyns K, Salado IG, Matheeussen A, De Esch I, De Koning HP, Leurs R, et al. Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi. The Journal of Antimicrobial Chemotherapy. PMID 31860098 DOI: 10.1093/Jac/Dkz516 |
0.334 |
|
| 2019 |
De Decker A, Vliegen G, Van Rompaey D, Peeraer A, Bracke A, Verckist L, Jansen K, Geiss-Friedlander R, Augustyns K, De Winter H, De Meester I, Lambeir AM, Van der Veken P. Novel Small Molecule-Derived, Highly Selective Substrates for Fibroblast Activation Protein (FAP). Acs Medicinal Chemistry Letters. 10: 1173-1179. PMID 31413802 DOI: 10.1021/Acsmedchemlett.9B00191 |
0.401 |
|
| 2019 |
Gladysz R, Vrijdag J, Van Rompaey D, Lambeir AM, Augustyns K, De Winter H, Van der Veken P. Efforts towards an On-Target Version of the Groebke-Blackburn-Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). 25: 12380-12393. PMID 31298443 DOI: 10.1002/Chem.201901917 |
0.329 |
|
| 2019 |
Sassetti E, Durante Cruz C, Tammela P, Winterhalter M, Augustyns K, Gribbon P, Windshügel B. Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent ClpP Inhibitors. International Journal of Molecular Sciences. 20. PMID 31159170 DOI: 10.3390/Ijms20112686 |
0.402 |
|
| 2019 |
Moreno-Cinos C, Goossens K, Salado IG, Van Der Veken P, De Winter H, Augustyns K. ClpP Protease, a Promising Antimicrobial Target. International Journal of Molecular Sciences. 20. PMID 31067645 DOI: 10.3390/Ijms20092232 |
0.317 |
|
| 2019 |
Tanc M, Cleenewerck M, Kurdi A, Roelandt R, Declercq W, De Meyer G, Augustyns K, Martinet W, Van der Veken P. Synthesis and evaluation of novel benzotropolones as Atg4B inhibiting autophagy blockers. Bioorganic Chemistry. 87: 163-168. PMID 30884310 DOI: 10.1016/J.Bioorg.2019.03.021 |
0.404 |
|
| 2019 |
Botros SS, William S, Sabra AA, El-Lakkany NM, Seif El-Din SH, García-Rubia A, Sebastián-Pérez V, Blaazer AR, de Heuvel E, Sijm M, Zheng Y, Salado IG, Munday JC, Maes L, de Esch IJP, ... ... Augustyns K, et al. Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity. International Journal For Parasitology. Drugs and Drug Resistance. 9: 35-43. PMID 30669086 DOI: 10.1016/J.Ijpddr.2019.01.001 |
0.316 |
|
| 2019 |
Moreno-Cinos C, Sassetti E, Salado IG, Witt G, Benramdane S, Reinhardt L, Cruz CD, Joossens J, Van der Veken P, Brötz-Oesterhelt H, Tammela P, Winterhalter M, Gribbon P, Windshügel B, Augustyns K. α-Amino Diphenyl Phosphonates as Novel Inhibitors of Escherichia coli ClpP Protease. Journal of Medicinal Chemistry. 62: 774-797. PMID 30571121 DOI: 10.1021/Acs.Jmedchem.8B01466 |
0.419 |
|
| 2018 |
Rogacki MK, Pitta E, Balabon OB, Huss S, Lopez-Roman EM, Argyrou A, Blanco-Ruano D, Cacho M, Vande Velde CML, Augustyns K, Ballell L, Barros D, Bates R, Cunningham F, Van der Veken P. Identification and profiling of hydantoins - a novel class of potent antimycobacterial DprE1 inhibitors. Journal of Medicinal Chemistry. PMID 30500189 DOI: 10.1021/Acs.Jmedchem.8B01356 |
0.403 |
|
| 2018 |
Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van der Veken P, Vandenabeele P, Berghe TV, Augustyns K. Discovery of Novel, Drug-like Ferroptosis Inhibitors with In Vivo Efficacy. Journal of Medicinal Chemistry. PMID 30354101 DOI: 10.1021/Acs.Jmedchem.8B01299 |
0.403 |
|
| 2018 |
Ceuleers H, Hanning N, Heirbaut J, Van Remoortel S, De Bruyn M, Joossens J, van der Veken P, Lambeir AM, Francque SM, De Man JG, Timmermans JP, Augustyns K, De Meester I, De Winter BY. Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome. British Journal of Pharmacology. PMID 29911328 DOI: 10.1111/Bph.14396 |
0.33 |
|
| 2018 |
Salado IG, Baán A, Verdeyen T, Matheeussen A, Caljon G, Van der Veken P, Kiekens F, Maes L, Augustyns K. Optimization of the pharmacokinetic properties of potent anti-trypanosomal triazine derivatives. European Journal of Medicinal Chemistry. 151: 18-26. PMID 29604541 DOI: 10.1016/J.Ejmech.2018.03.048 |
0.359 |
|
| 2018 |
Coornaert I, Hofmans S, Devisscher L, Augustyns K, Van Der Veken P, De Meyer GRY, Martinet W. Novel drug discovery strategies for atherosclerosis that target necrosis and necroptosis. Expert Opinion On Drug Discovery. 1-12. PMID 29598451 DOI: 10.1080/17460441.2018.1457644 |
0.371 |
|
| 2018 |
Hofmans S, Devisscher L, Martens S, Van Rompaey D, Goossens K, Divert T, Nerinckx W, Takahashi N, De Winter H, Van Der Veken P, Goossens V, Vandenabeele P, Augustyns K. Tozasertib Analogues as Inhibitors of Necroptotic Cell Death. Journal of Medicinal Chemistry. PMID 29437386 DOI: 10.1021/Acs.Jmedchem.7B01449 |
0.403 |
|
| 2018 |
Martens S, Goossens V, Devisscher L, Hofmans S, Claeys P, Vuylsteke M, Takahashi N, Augustyns K, Vandenabeele P. RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680). Cell Death & Disease. 9: 211. PMID 29434255 DOI: 10.1038/S41419-017-0245-7 |
0.358 |
|
| 2018 |
Venkatraj M, Salado IG, Heeres J, Joossens J, Lewi PJ, Caljon G, Maes L, Van der Veken P, Augustyns K. Novel triazine dimers with potent antitrypanosomal activity. European Journal of Medicinal Chemistry. 143: 306-319. PMID 29197735 DOI: 10.1016/J.Ejmech.2017.11.075 |
0.379 |
|
| 2018 |
Adriaenssens Y, Jiménez Fernández D, Vande Walle L, Elvas F, Joossens J, Lambeir A, Augustyns K, Lamkanfi M, Van der Veken P. Carboxylate isosteres for caspase inhibitors: the acylsulfonamide case revisited. Organic & Biomolecular Chemistry. 15: 7456-7473. PMID 28837200 DOI: 10.1039/C7Ob01403A |
0.427 |
|
| 2018 |
Ceuleers H, Li Q, De Man J, Liu L, Joossens J, Augustyns K, De Meester I, De Winter BY, Pasricha PJ. Mo1597 - Targeting the Serine Protease Pathway in IBS: Beneficial Effects of a Novel small Molecule Inhibitor in Mice Gastroenterology. 154: S-765. DOI: 10.1016/S0016-5085(18)32648-9 |
0.335 |
|
| 2017 |
Van Rompaey D, Verstraete K, Peelman F, Savvides SN, Augustyns K, Van Der Veken P, De Winter H. Virtual screening for inhibitors of the human TSLP:TSLPR interaction. Scientific Reports. 7: 17211. PMID 29222519 DOI: 10.1038/S41598-017-17620-7 |
0.335 |
|
| 2017 |
Chirumamilla CS, Palagani A, Kamaraj B, Declerck K, Verbeek MWC, Oksana R, De Bosscher K, Bougarne N, Ruttens B, Gevaert K, Houtman R, De Vos WH, Joossens J, Van Der Veken P, Augustyns K, et al. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Frontiers in Immunology. 8: 1324. PMID 29163463 DOI: 10.3389/Fimmu.2017.01324 |
0.324 |
|
| 2017 |
Rea D, Van Elzen R, De Winter H, Van Goethem S, Landuyt B, Luyten W, Schoofs L, Van Der Veken P, Augustyns K, De Meester I, Fülöp V, Lambeir AM. Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling. European Journal of Medicinal Chemistry. 139: 482-491. PMID 28826083 DOI: 10.1016/J.Ejmech.2017.08.024 |
0.356 |
|
| 2017 |
Martens S, Jeong M, Tonnus W, Feldmann F, Hofmans S, Goossens V, Takahashi N, Bräsen JH, Lee EW, Van der Veken P, Joossens J, Augustyns K, Fulda S, Linkermann A, Song J, et al. Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury. Cell Death & Disease. 8: e2904. PMID 28661484 DOI: 10.1038/Cddis.2017.298 |
0.352 |
|
| 2017 |
Kurdi A, Cleenewerck M, Vangestel C, Lyssens S, Declercq W, Timmermans JP, Stroobants S, Augustyns K, De Meyer GRY, Van Der Veken P, Martinet W. ATG4B inhibitors with a benzotropolone core structure block autophagy and augment efficiency of chemotherapy in mice. Biochemical Pharmacology. PMID 28642033 DOI: 10.1016/J.Bcp.2017.06.119 |
0.39 |
|
| 2017 |
Rojas-Rivera D, Delvaeye T, Roelandt R, Nerinckx W, Augustyns K, Vandenabeele P, Bertrand MJM. When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell Death and Differentiation. PMID 28452996 DOI: 10.1038/Cdd.2017.58 |
0.359 |
|
| 2016 |
Ceuleers H, Van Spaendonk H, Hanning N, Heirbaut J, Lambeir AM, Joossens J, Augustyns K, De Man JG, De Meester I, De Winter BY. Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases. World Journal of Gastroenterology. 22: 10275-10286. PMID 28058009 DOI: 10.3748/Wjg.V22.I47.10275 |
0.35 |
|
| 2016 |
Pitta E, Balabon O, Rogacki MK, Gómez J, Cunningham F, Joosens J, Augustyns K, van der Veken P, Bates R. Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity. European Journal of Medicinal Chemistry. 125: 890-901. PMID 27769030 DOI: 10.1016/J.Ejmech.2016.10.014 |
0.339 |
|
| 2016 |
Vangestel C, Thomae D, Van Soom J, Ides J, Wyffels L, Pauwels P, Stroobants S, Van der Veken P, Magdolen V, Joossens J, Augustyns K, Staelens S. Preclinical evaluation of [(111) In]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity. Contrast Media & Molecular Imaging. PMID 27558262 DOI: 10.1002/Cmmi.1706 |
0.301 |
|
| 2016 |
Cleenewerck M, Grootaert MO, Gladysz R, Adriaenssens Y, Roelandt R, Joossens J, Lambeir AM, De Meyer GR, Declercq W, Augustyns K, Martinet W, Van der Veken P. Inhibitor screening and enzymatic activity determination for autophagy target Atg4B using a gel electrophoresis-based assay. European Journal of Medicinal Chemistry. 123: 631-638. PMID 27517808 DOI: 10.1016/J.Ejmech.2016.07.073 |
0.42 |
|
| 2016 |
Pitta E, Rogacki MK, Balabon O, Huss S, Cunningham F, Lopez-Roman EM, Joossens J, Augustyns K, Ballell L, Bates RH, Van der Veken P. Searching for new leads for Tuberculosis: Design, synthesis and biological evaluation of novel 2-quinolin-4-yloxyacetamides. Journal of Medicinal Chemistry. PMID 27348630 DOI: 10.1021/Acs.Jmedchem.6B00245 |
0.351 |
|
| 2016 |
Gladysz R, Lambeir AM, Joossens J, Augustyns K, Van der Veken P. Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry. Chemmedchem. 11: 467-76. PMID 26845065 DOI: 10.1002/Cmdc.201500569 |
0.382 |
|
| 2016 |
Hofmans S, Vanden Berghe T, Devisscher L, Hassannia B, Lyssens S, Joossens J, Van Der Veken P, Vandenabeele P, Augustyns K. Novel Ferroptosis Inhibitors with Improved Potency and ADME Properties. Journal of Medicinal Chemistry. 59: 2041-53. PMID 26696014 DOI: 10.1021/Acs.Jmedchem.5B01641 |
0.421 |
|
| 2016 |
Heirbaut L, Van Goethem S, Jansen K, De Winter H, Lamoen N, Joossens J, Cheng J, Chen X, Lambeir AM, De Meester I, Augustyns K, Van Der Veken P. Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: The impact of P1-variation Medchemcomm. 7: 433-438. DOI: 10.1039/C5Md00454C |
0.388 |
|
| 2015 |
Gladysz R, Adriaenssens Y, De Winter H, Joossens J, Lambeir AM, Augustyns K, Van der Veken P. Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold. Journal of Medicinal Chemistry. 58: 9238-57. PMID 26575094 DOI: 10.1021/Acs.Jmedchem.5B01171 |
0.414 |
|
| 2015 |
Moss CX, Brown E, Hamilton A, Van der Veken P, Augustyns K, Mottram JC. An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei. Plos One. 10: e0123241. PMID 25816352 DOI: 10.1371/Journal.Pone.0123241 |
0.317 |
|
| 2015 |
Van Soom J, Cuzzucoli Crucitti G, Gladysz R, Van Der Veken P, Di Santo R, Stuyver I, Buck V, Lambeir AM, Magdolen V, Joossens J, Augustyns K. The first potent diphenyl phosphonate KLK4 inhibitors with unexpected binding kinetics Medchemcomm. 6: 1954-1958. DOI: 10.1039/C5Md00288E |
0.378 |
|
| 2014 |
Venkatraj M, Ariën KK, Heeres J, Joossens J, Dirié B, Lyssens S, Michiels J, Cos P, Lewi PJ, Vanham G, Maes L, Van der Veken P, Augustyns K. From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds. Bioorganic & Medicinal Chemistry. 22: 5241-8. PMID 25199582 DOI: 10.1016/J.Bmc.2014.08.005 |
0.398 |
|
| 2014 |
Gladysz R, Cleenewerck M, Joossens J, Lambeir AM, Augustyns K, Van der Veken P. Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders. Chembiochem : a European Journal of Chemical Biology. 15: 2238-47. PMID 25154878 DOI: 10.1002/Cbic.201402192 |
0.367 |
|
| 2014 |
Jansen K, Heirbaut L, Verkerk R, Cheng JD, Joossens J, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, Van Der Veken P. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) Journal of Medicinal Chemistry. 57: 3053-3074. PMID 24617858 DOI: 10.1021/Jm500031W |
0.432 |
|
| 2014 |
Grammen C, Ariën KK, Venkatraj M, Joossens J, Van der Veken P, Heeres J, Lewi PJ, Haenen S, Augustyns K, Vanham G, Augustijns P, Brouwers J. Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1. Antiviral Research. 101: 113-21. PMID 24269474 DOI: 10.1016/J.Antiviral.2013.11.005 |
0.311 |
|
| 2014 |
Jansen K, De Winter H, Heirbaut L, Cheng JD, Joossens J, Lambeir AM, De Meester I, Augustyns K, Van Der Veken P. Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold Medchemcomm. 5: 1700-1707. DOI: 10.1039/C4Md00167B |
0.453 |
|
| 2014 |
De Brabandere S, Mangelinckx S, Kadam ST, Nural Y, Augustyns K, Van Der Veken P, Törnroos KW, De Kimpe N. Synthesis of γ,δ-aziridino α-amino acid derivatives and their stereoselective ring transformation to 2-(aminomethyl)-1- aminocyclopropanecarboxylic acid derivatives European Journal of Organic Chemistry. 2014: 1220-1226. DOI: 10.1002/Ejoc.201301030 |
0.347 |
|
| 2013 |
Jansen K, Heirbaut L, Cheng JD, Joossens J, Ryabtsova O, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, Van der Veken P. Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. Acs Medicinal Chemistry Letters. 4: 491-6. PMID 24900696 DOI: 10.1021/Ml300410D |
0.443 |
|
| 2013 |
Giannese F, Berg M, Van Der Veken P, Castagna V, Tornaghi P, Augustyns K, Degano M. Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor Acta Crystallographica Section D: Biological Crystallography. 69: 1553-1566. PMID 23897478 DOI: 10.1107/S0907444913010792 |
0.442 |
|
| 2012 |
Van der Veken P, Fülöp V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K. P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy. Journal of Medicinal Chemistry. 55: 9856-67. PMID 23121075 DOI: 10.1021/Jm301060G |
0.428 |
|
| 2012 |
Venkatraj M, Ariën KK, Heeres J, Joossens J, Messagie J, Michiels J, Van der Veken P, Vanham G, Lewi PJ, Augustyns K. Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents. Bioorganic & Medicinal Chemistry Letters. 22: 7174-8. PMID 23084903 DOI: 10.1016/J.Bmcl.2012.09.066 |
0.357 |
|
| 2012 |
Ryabtsova O, Jansen K, Van Goethem S, Joossens J, Cheng JD, Lambeir AM, De Meester I, Augustyns K, Van der Veken P. Acylated Gly-(2-cyano)pyrrolidines as inhibitors of fibroblast activation protein (FAP) and the issue of FAP/prolyl oligopeptidase (PREP)-selectivity. Bioorganic & Medicinal Chemistry Letters. 22: 3412-7. PMID 22525314 DOI: 10.1016/J.Bmcl.2012.03.107 |
0.466 |
|
| 2012 |
Venkatraj M, Messagie J, Joossens J, Lambeir AM, Haemers A, Van der Veken P, Augustyns K. Synthesis and evaluation of non-basic inhibitors of urokinase-type plasminogen activator (uPA). Bioorganic & Medicinal Chemistry. 20: 1557-68. PMID 22285569 DOI: 10.1016/J.Bmc.2011.12.040 |
0.413 |
|
| 2012 |
Ides J, Wouters A, Messagie J, Vangestel C, Pauwels B, Joossens J, Veken PVd, Augustyns K, Peeters M, Lardon F. Abstract 5250: Optimization of an orthotopic mouse model forin vivofluorescent uPA imaging in breast cancer Cancer Research. 72: 5250-5250. DOI: 10.1158/1538-7445.Am2012-5250 |
0.302 |
|
| 2011 |
Venkatraj M, Ariën KK, Heeres J, Dirié B, Joossens J, Van Goethem S, Van der Veken P, Michiels J, Vande Velde CM, Vanham G, Lewi PJ, Augustyns K. Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs). Bioorganic & Medicinal Chemistry. 19: 5924-34. PMID 21930388 DOI: 10.1016/J.Bmc.2011.08.060 |
0.326 |
|
| 2011 |
Van Goethem S, Matheeussen V, Joossens J, Lambeir AM, Chen X, De Meester I, Haemers A, Augustyns K, Van der Veken P. Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? Journal of Medicinal Chemistry. 54: 5737-46. PMID 21711053 DOI: 10.1021/Jm200383J |
0.431 |
|
| 2011 |
Matheeussen V, Baerts L, De Meyer G, De Keulenaer G, Van der Veken P, Augustyns K, Dubois V, Scharpé S, De Meester I. Expression and spatial heterogeneity of dipeptidyl peptidases in endothelial cells of conduct vessels and capillaries. Biological Chemistry. 392: 189-98. PMID 21194356 DOI: 10.1515/Bc.2011.002 |
0.309 |
|
| 2011 |
Ariën KK, Venkatraj M, Míchiels J, Joossens J, der Veken P, Heeres J, Abdellati S, Cuylaerts V, Crucitti T, Lewi P, Augustyns K, Vanham G. Development of triazine non-nucleoside reverse transcriptase inhibitors for microbicidal applications Retrovirology. 8. DOI: 10.1186/1742-4690-8-S2-P1 |
0.327 |
|
| 2010 |
Steert K, Berg M, Mottram JC, Westrop GD, Coombs GH, Cos P, Maes L, Joossens J, Van der Veken P, Haemers A, Augustyns K. α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. Chemmedchem. 5: 1734-48. PMID 20799311 DOI: 10.1002/Cmdc.201000265 |
0.426 |
|
| 2010 |
Berg M, Van der Veken P, Goeminne A, Haemers A, Augustyns K. Inhibitors of the purine salvage pathway: a valuable approach for antiprotozoal chemotherapy? Current Medicinal Chemistry. 17: 2456-81. PMID 20491648 DOI: 10.2174/092986710791556023 |
0.411 |
|
| 2010 |
Heylen E, Van Goethem S, Augustyns K, Hendriks D. Measurement of carboxypeptidase U (active thrombin-activatable fibrinolysis inhibitor) in plasma: Challenges overcome by a novel selective assay. Analytical Biochemistry. 403: 114-6. PMID 20371219 DOI: 10.1016/J.Ab.2010.03.045 |
0.316 |
|
| 2010 |
Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi MI, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning HP, ... Augustyns K, et al. Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. Antimicrobial Agents and Chemotherapy. 54: 1900-8. PMID 20194690 DOI: 10.1128/Aac.01787-09 |
0.39 |
|
| 2010 |
Bastos IMD, Motta FN, Charneau S, Santana JM, Dubost L, Augustyns K, Grellier P. Prolyl oligopeptidase of Trypanosoma brucei hydrolyzes native collagen, peptide hormones and is active in the plasma of infected mice Microbes and Infection. 12: 457-466. PMID 20188209 DOI: 10.1016/J.Micinf.2010.02.007 |
0.311 |
|
| 2010 |
Berg M, Van der Veken P, Joossens J, Muthusamy V, Breugelmans M, Moss CX, Rudolf J, Cos P, Coombs GH, Maes L, Haemers A, Mottram JC, Augustyns K. Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 2001-6. PMID 20167486 DOI: 10.1016/J.Bmcl.2010.01.099 |
0.419 |
|
| 2010 |
Jungraithmayr W, De Meester I, Matheeussen V, Inci I, Augustyns K, Scharpé S, Weder W, Korom S. Inhibition of CD26/DPP IV attenuates ischemia/reperfusion injury in orthotopic mouse lung transplants: the pivotal role of vasoactive intestinal peptide. Peptides. 31: 585-91. PMID 20018218 DOI: 10.1016/J.Peptides.2009.12.012 |
0.312 |
|
| 2010 |
Heylen E, Van Goethem S, Willemse J, Olsson T, Augustyns K, Hendriks D. Development of a sensitive and selective assay for the determination of procarboxypeptidase U (thrombin-activatable fibrinolysis inhibitor) in plasma. Analytical Biochemistry. 396: 152-4. PMID 19732738 DOI: 10.1016/J.Ab.2009.08.037 |
0.365 |
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| 2009 |
Jungraithmayr W, Oberreiter B, De Meester I, Wiedl T, Inci I, Bain M, Augustyns K, Hillinger S, Scharpé S, Weder W, Korom S. The effect of organ-specific cd26/dpp iv enzymatic activity inhibitor-preconditioning on acute pulmonary allograft rejection Transplantation. 88: 478-485. PMID 19696630 DOI: 10.1097/Tp.0B013E3181B08E77 |
0.301 |
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| 2009 |
El Sayed I, Van der Veken P, Steert K, Dhooghe L, Hostyn S, Van Baelen G, Lemière G, Maes BU, Cos P, Maes L, Joossens J, Haemers A, Pieters L, Augustyns K. Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives. Journal of Medicinal Chemistry. 52: 2979-88. PMID 19364118 DOI: 10.1021/Jm801490Z |
0.348 |
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| 2009 |
Versées W, Goeminne A, Berg M, Vandemeulebroucke A, Haemers A, Augustyns K, Steyaert J. Crystal structures of T. vivax nucleoside hydrolase in complex with new potent and specific inhibitors. Biochimica Et Biophysica Acta. 1794: 953-60. PMID 19281874 DOI: 10.1016/J.Bbapap.2009.02.011 |
0.387 |
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| 2009 |
Dubois V, Van Ginneken C, De Cock H, Lambeir AM, Van der Veken P, Augustyns K, Chen X, Scharpé S, De Meester I. Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 57: 531-41. PMID 19188489 DOI: 10.1369/Jhc.2009.952739 |
0.326 |
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| 2009 |
Berg M, Bal G, Goeminne A, Van der Veken P, Versées W, Steyaert J, Haemers A, Augustyns K. Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors. Chemmedchem. 4: 249-60. PMID 19115304 DOI: 10.1002/Cmdc.200800231 |
0.644 |
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| 2009 |
Jost MM, Lamerz J, Tammen H, Menzel C, De Meester I, Lambeir AM, Augustyns K, Scharpé S, Zucht HD, Rose H, Jürgens M, Schulz-Knappe P, Budde P. In vivo profiling of DPP4 inhibitors reveals alterations in collagen metabolism and accumulation of an amyloid peptide in rat plasma. Biochemical Pharmacology. 77: 228-37. PMID 18940185 DOI: 10.1016/J.Bcp.2008.09.032 |
0.364 |
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| 2008 |
Goeminne A, Berg M, McNaughton M, Bal G, Surpateanu G, Van der Veken P, De Prol S, Versées W, Steyaert J, Haemers A, Augustyns K. N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase. Bioorganic & Medicinal Chemistry. 16: 6752-63. PMID 18571422 DOI: 10.1016/J.Bmc.2008.05.056 |
0.625 |
|
| 2008 |
Van der Veken P, De Meester I, Dubois V, Soroka A, Van Goethem S, Maes MB, Brandt I, Lambeir AM, Chen X, Haemers A, Scharpé S, Augustyns K. Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads. Bioorganic & Medicinal Chemistry Letters. 18: 4154-8. PMID 18556199 DOI: 10.1016/J.Bmcl.2008.05.080 |
0.433 |
|
| 2008 |
Van Goethem S, Van der Veken P, Dubois V, Soroka A, Lambeir AM, Chen X, Haemers A, Scharpé S, De Meester I, Augustyns K. Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 4159-62. PMID 18556198 DOI: 10.1016/J.Bmcl.2008.05.079 |
0.461 |
|
| 2008 |
Dubois V, Lambeir AM, Van der Veken P, Augustyns K, Creemers J, Chen X, Scharpé S, De Meester I. Purification and characterization of dipeptidyl peptidase IV-like enzymes from bovine testes. Frontiers in Bioscience : a Journal and Virtual Library. 13: 3558-68. PMID 18508455 DOI: 10.2741/2949 |
0.329 |
|
| 2008 |
Goeminne A, McNaughton M, Bal G, Surpateanu G, Van Der Veken P, De Prol S, Versées W, Steyaert J, Haemers A, Augustyns K. Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors. European Journal of Medicinal Chemistry. 43: 315-26. PMID 17582660 DOI: 10.1016/J.Ejmech.2007.03.027 |
0.626 |
|
| 2007 |
Joossens J, Ali OM, El-Sayed I, Surpateanu G, Van der Veken P, Lambeir AM, Setyono-Han B, Foekens JA, Schneider A, Schmalix W, Haemers A, Augustyns K. Small, potent, and selective diaryl phosphonate inhibitors for urokinase-type plasminogen activator with in vivo antimetastatic properties. Journal of Medicinal Chemistry. 50: 6638-46. PMID 18052026 DOI: 10.1021/Jm700962J |
0.429 |
|
| 2007 |
Van der Veken P, Soroka A, Brandt I, Chen YS, Maes MB, Lambeir AM, Chen X, Haemers A, Scharpé S, Augustyns K, De Meester I. Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. Journal of Medicinal Chemistry. 50: 5568-70. PMID 17958345 DOI: 10.1021/Jm701005A |
0.448 |
|
| 2007 |
Steert K, El-Sayed I, Van der Veken P, Krishtal A, Van Alsenoy C, Westrop GD, Mottram JC, Coombs GH, Augustyns K, Haemers A. Dipeptidyl alpha-fluorovinyl Michael acceptors: synthesis and activity against cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 17: 6563-6. PMID 17936625 DOI: 10.1016/J.Bmcl.2007.09.075 |
0.31 |
|
| 2007 |
Van der Veken P, Haemers A, Augustyns K. Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery. Current Topics in Medicinal Chemistry. 7: 621-35. PMID 17352682 DOI: 10.2174/156802607780091046 |
0.403 |
|
| 2007 |
Goeminne A, McNaughton M, Bal G, Surpateanu G, Van der Veken P, De Prol S, Versées W, Steyaert J, Apers S, Haemers A, Augustyns K. 1,2,3-Triazolylalkylribitol derivatives as nucleoside hydrolase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 2523-6. PMID 17317181 DOI: 10.1016/J.Bmcl.2007.02.017 |
0.643 |
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| 2007 |
Maes MB, Dubois V, Brandt I, Lambeir AM, Van der Veken P, Augustyns K, Cheng JD, Chen X, Scharpé S, De Meester I. Dipeptidyl peptidase 8/9-like activity in human leukocytes. Journal of Leukocyte Biology. 81: 1252-7. PMID 17287297 DOI: 10.1189/Jlb.0906546 |
0.391 |
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| 2006 |
Casteleijn MG, Alahuhta M, Groebel K, El-Sayed I, Augustyns K, Lambeir AM, Neubauer P, Wierenga RK. Functional role of the conserved active site proline of triosephosphate isomerase. Biochemistry. 45: 15483-94. PMID 17176070 DOI: 10.1021/Bi061683J |
0.313 |
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| 2006 |
Joossens J, Van der Veken P, Surpateanu G, Lambeir AM, El-Sayed I, Ali OM, Augustyns K, Haemers A. Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position. Journal of Medicinal Chemistry. 49: 5785-93. PMID 16970403 DOI: 10.1021/Jm060622G |
0.44 |
|
| 2006 |
Soroka A, Van der Veken P, De Meester I, Lambeir AM, Maes MB, Scharpé S, Haemers A, Augustyns K. Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines. Bioorganic & Medicinal Chemistry Letters. 16: 4777-9. PMID 16844373 DOI: 10.1016/J.Bmcl.2006.06.082 |
0.373 |
|
| 2006 |
Maes MB, Martinet W, Schrijvers DM, Van der Veken P, De Meyer GR, Augustyns K, Lambeir AM, Scharpé S, De Meester I. Dipeptidyl peptidase II and leukocyte cell death. Biochemical Pharmacology. 72: 70-9. PMID 16725115 DOI: 10.1016/J.Bcp.2006.04.009 |
0.378 |
|
| 2006 |
Maes MB, Lambeir AM, Van der Veken P, De Winter B, Augustyns K, Scharpé S, De Meester I. In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII. Advances in Experimental Medicine and Biology. 575: 73-85. PMID 16700510 DOI: 10.1007/0-387-32824-6_8 |
0.388 |
|
| 2005 |
Augustyns K, Van der Veken P, Senten K, Haemers A. The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases. Current Medicinal Chemistry. 12: 971-98. PMID 15853709 DOI: 10.2174/0929867053507298 |
0.369 |
|
| 2005 |
Van der Veken P, Senten K, Kertèsz I, De Meester I, Lambeir AM, Maes MB, Scharpé S, Haemers A, Augustyns K. Fluoro-olefins as peptidomimetic inhibitors of dipeptidyl peptidases. Journal of Medicinal Chemistry. 48: 1768-80. PMID 15771423 DOI: 10.1021/Jm0495982 |
0.351 |
|
| 2005 |
Bastos IM, Grellier P, Martins NF, Cadavid-Restrepo G, de Souza-Ault MR, Augustyns K, Teixeira AR, Schrével J, Maigret B, da Silveira JF, Santana JM. Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells. The Biochemical Journal. 388: 29-38. PMID 15581422 DOI: 10.1042/Bj20041049 |
0.35 |
|
| 2005 |
Maes MB, Lambeir AM, Gilany K, Senten K, Van der Veken P, Leiting B, Augustyns K, Scharpé S, De Meester I. Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). The Biochemical Journal. 386: 315-24. PMID 15487984 DOI: 10.1042/Bj20041156 |
0.328 |
|
| 2005 |
Augustyns K, Van der Veken P, Haemers A. Inhibitors of proline-specific dipeptidyl peptidases: DPP IV inhibitors as a novel approach for the treatment of type 2 diabetes Expert Opinion On Therapeutic Patents. 15: 1387-1407. DOI: 10.1517/13543776.15.10.1387 |
0.393 |
|
| 2004 |
Senten K, Van Der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K. Gamma-amino-substituted analogues of 1-[(S)-2,4-diaminobutanoyl]piperidine as highly potent and selective dipeptidyl peptidase II inhibitors. Journal of Medicinal Chemistry. 47: 2906-16. PMID 15139769 DOI: 10.1021/Jm031122F |
0.419 |
|
| 2004 |
Pil J, Van der Veken P, Bal G, Augustyns K, Haemers A, Tytgat J. Synthesis and electrophysiological characterization of cyclic morphiceptin analogues. Biochemical Pharmacology. 67: 1887-95. PMID 15130765 DOI: 10.1016/J.Bcp.2004.02.011 |
0.528 |
|
| 2004 |
Joossens J, Van der Veken P, Lambeir AM, Augustyns K, Haemers A. Development of irreversible diphenyl phosphonate inhibitors for urokinase plasminogen activator. Journal of Medicinal Chemistry. 47: 2411-3. PMID 15115382 DOI: 10.1021/Jm0499209 |
0.408 |
|
| 2003 |
Bal G, Van der Veken P, Antonov D, Lambeir AM, Grellier P, Croft SL, Augustyns K, Haemers A. Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity. Bioorganic & Medicinal Chemistry Letters. 13: 2875-8. PMID 14611847 DOI: 10.1016/S0960-894X(03)00579-1 |
0.623 |
|
| 2003 |
Senten K, Van der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K. Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases. Journal of Medicinal Chemistry. 46: 5005-14. PMID 14584950 DOI: 10.1021/Jm0308803 |
0.41 |
|
| 2003 |
Senten K, Daniëls L, Van der Veken P, De Meester I, Lambeir AM, Scharpé S, Haemers A, Augustyns K. Rapid parallel synthesis of dipeptide diphenyl phosphonate esters as inhibitors of dipeptidyl peptidases. Journal of Combinatorial Chemistry. 5: 336-44. PMID 12739951 DOI: 10.1021/Cc020096O |
0.386 |
|
| 2003 |
Lambeir AM, Rea D, Fülöp V, Kumagai Y, Augustyns K, de Meester I, Haemers A, Scharpé S. Exploration of the active site of dipeptidyl peptidase IV from Porphyromonas gingivalis. Comparison with the human enzyme. Advances in Experimental Medicine and Biology. 524: 29-35. PMID 12675220 DOI: 10.1007/0-306-47920-6_3 |
0.301 |
|
| 2003 |
Augustyns K, Van der Veken P, Senten K, Haemers A. Dipeptidyl peptidase IV inhibitors as new therapeutic agents for the treament of type 2 diabetes Expert Opinion On Therapeutic Patents. 13: 499-510. DOI: 10.1517/13543776.13.4.499 |
0.309 |
|
| 2003 |
Van Der Veken P, Kertèsz I, Senten K, Haemers A, Augustyns K. Synthesis of (E)- and (Z)-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors Tetrahedron Letters. 44: 6231-6234. DOI: 10.1016/S0040-4039(03)01542-9 |
0.341 |
|
| 2003 |
Van Der Veken P, Senten K, Kertèsz I, Haemers A, Augustyns K. β-fluorinated proline derivatives: Potential transition state inhibitors for proline selective serine dipeptidases Tetrahedron Letters. 44: 969-972. DOI: 10.1016/S0040-4039(02)02764-8 |
0.356 |
|
| 2002 |
Senten K, Van der Veken P, Bal G, De Meester I, Lambeir AM, Scharpé S, Bauvois B, Haemers A, Augustyns K. Development of potent and selective dipeptidyl peptidase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 2825-8. PMID 12270155 DOI: 10.1016/S0960-894X(02)00603-0 |
0.591 |
|
| 2002 |
Amssoms K, Oza SL, Augustyns K, Yamani A, Lambeir AM, Bal G, Van der Veken P, Fairlamb AH, Haemers A. Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 2: substitution of the glycine part. Bioorganic & Medicinal Chemistry Letters. 12: 2703-5. PMID 12217358 DOI: 10.1016/S0960-894X(02)00538-3 |
0.782 |
|
| 2002 |
Amssoms K, Oza SL, Ravaschino E, Yamani A, Lambeir A, Rajan P, Bal G, Rodriguez J, Fairlamb AH, Augustyns K, Haemers A. Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group. Bioorganic & Medicinal Chemistry Letters. 12: 2553-6. PMID 12182858 DOI: 10.1016/S0960-894X(02)00489-4 |
0.759 |
|
| 2002 |
Cos P, Rajan P, Vedernikova I, Calomme M, Pieters L, Vlietinck AJ, Augustyns K, Haemers A, Vanden Berghe D. In vitro antioxidant profile of phenolic acid derivatives. Free Radical Research. 36: 711-6. PMID 12180197 DOI: 10.1080/10715760290029182 |
0.338 |
|
| 2002 |
Amssoms K, Augustyns K, Yamani A, Zhang M, Haemers A. An efficient synthesis of orthogonally protected spermidine Synthetic Communications. 32: 319-328. DOI: 10.1081/Scc-120002114 |
0.34 |
|
| 2001 |
Augustyns K, Amssoms K, Yamani A, Rajan PK, Haemers A. Trypanothione as a target in the design of antitrypanosomal and antileishmanial agents. Current Pharmaceutical Design. 7: 1117-41. PMID 11472257 DOI: 10.2174/1381612013397564 |
0.304 |
|
| 2001 |
Lambeir AM, Proost P, Durinx C, Bal G, Senten K, Augustyns K, Scharpé S, Van Damme J, De Meester I. Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family. The Journal of Biological Chemistry. 276: 29839-45. PMID 11390394 DOI: 10.1074/Jbc.M103106200 |
0.556 |
|
| 2001 |
Rajan P, Vedernikova I, Cos P, Berghe DV, Augustyns K, Haemers A. Synthesis and evaluation of caffeic acid amides as antioxidants. Bioorganic & Medicinal Chemistry Letters. 11: 215-7. PMID 11206462 DOI: 10.1016/S0960-894X(00)00630-2 |
0.332 |
|
| 2001 |
Senten K, Van Der Veken P, Bal G, Haemers A, Augustyns K. Polymer-assisted solution-phase parallel synthesis of dipeptide p-nitroanilides and dipeptide diphenyl phosphonates Tetrahedron Letters. 42: 9135-9138. DOI: 10.1016/S0040-4039(01)01954-2 |
0.544 |
|
| 2000 |
De Meester I, Durinx C, Bal G, Proost P, Struyf S, Goossens F, Augustyns K, Scharpé S. Natural substrates of dipeptidyl peptidase IV. Advances in Experimental Medicine and Biology. 477: 67-87. PMID 10849732 DOI: 10.1007/0-306-46826-3_7 |
0.542 |
|
| 1999 |
Augustyns K, Bal G, Thonus G, Belyaev A, Zhang XM, Bollaert W, Lambeir AM, Durinx C, Goossens F, Haemers A. The unique properties of dipeptidyl-peptidase IV (DPP IV / CD26) and the therapeutic potential of DPP IV inhibitors. Current Medicinal Chemistry. 6: 311-27. PMID 10101215 |
0.546 |
|
| 1999 |
Belyaev A, Zhang X, Augustyns K, Lambeir AM, De Meester I, Vedernikova I, Scharpé S, Haemers A. Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors. Journal of Medicinal Chemistry. 42: 1041-52. PMID 10090787 DOI: 10.1021/Jm981033G |
0.404 |
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| 1999 |
Proost P, Struyf S, Schols D, Opdenakker G, Sozzani S, Allavena P, Mantovani A, Augustyns K, Bal G, Haemers A, Lambeir AM, Scharpé S, Van Damme J, De Meester I. Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction. The Journal of Biological Chemistry. 274: 3988-93. PMID 9933589 DOI: 10.1074/Jbc.274.7.3988 |
0.543 |
|
| 1997 |
Goossens F, Vanhoof G, De Meester I, Augustyns K, Borloo M, Tourwe D, Haemers A, Scharpé S. Development and evaluation of peptide-based prolyl oligopeptidase inhibitors--introduction of N-benzyloxycarbonyl-prolyl-3-fluoropyrrolidine as a lead in inhibitor design. European Journal of Biochemistry / Febs. 250: 177-83. PMID 9432007 DOI: 10.1111/J.1432-1033.1997.00177.X |
0.433 |
|
| 1997 |
Augustyns KJL, Lambeir AM, Borloo M, De Meester I, Vedernikova I, Vanhoof G, Hendriks D, Scharpé S, Haemers A. Pyrrolidides: Synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV European Journal of Medicinal Chemistry. 32: 301-309. DOI: 10.1016/S0223-5234(97)89082-4 |
0.309 |
|
| 1996 |
Lambeir AM, Borloo M, De Meester I, Belyaev A, Augustyns K, Hendriks D, Scharpé S, Haemers A. Dipeptide-derived diphenyl phosphonate esters: mechanism-based inhibitors of dipeptidyl peptidase IV. Biochimica Et Biophysica Acta. 1290: 76-82. PMID 8645710 DOI: 10.1016/0304-4165(96)00012-8 |
0.462 |
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| 1995 |
Augustyns K, Borloo M, Belyaev A, Rajan P, Goossens F, Hendriks D, Scharpé S, Haemers A. Synthesis of peptidyl acetals as inhibitors of prolyl endopeptidase Bioorganic and Medicinal Chemistry Letters. 5: 1265-1270. DOI: 10.1016/0960-894X(95)00206-9 |
0.379 |
|
| 1995 |
Borloo M, Augustyns K, Belyaev A, de Meester I, Lambeir AM, Goossens F, Bollaert W, Rajan P, Scharpé S, Haemers A. Synthesis and evaluation of azaproline peptides as potential inhibitors of dipeptidyl peptidase IV and prolyl oligopeptidase Letters in Peptide Science. 2: 198-202. DOI: 10.1007/Bf00119152 |
0.435 |
|
| 1992 |
Augustyns K, van Aerschot A, Urbanke C, Herdewijn P. Influence of the Incorporation of 1‐(2,3‐Dideoxy‐β‐D‐Erythro‐Hexopyranosyl)‐Thymine on the Enzymatic Stability and Base‐Pairing Properties of Oligodeoxynucleotides Bulletin Des SociéTéS Chimiques Belges. 101: 119-130. DOI: 10.1002/Bscb.19921010207 |
0.315 |
|
| 1991 |
Augustyns K, Van Aerschot A, Herdewijn P. Ugar Modified Oligonucleotides Nucleosides and Nucleotides. 10: 587-588. DOI: 10.1080/07328319108046538 |
0.323 |
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