Robert T. Schimke - Publications

Affiliations: 
Biological Sciences Stanford University, Palo Alto, CA 
Area:
protein turnover and gene amplification
Website:
http://www.asbmb.org/uploadedfiles/aboutus/asbmb_history/past_presidents/1980s/1988Schimke.html

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1996 Yin DX, Zhu L, Schimke RT. Tetracycline-controlled gene expression system achieves high-level and quantitative control of gene expression. Analytical Biochemistry. 235: 195-201. PMID 8833328 DOI: 10.1006/Abio.1996.0112  0.377
1996 Yin DX, Schimke RT. Inhibition of apoptosis by overexpressing Bcl-2 enhances gene amplification by a mechanism independent of aphidicolin pretreatment. Proceedings of the National Academy of Sciences of the United States of America. 93: 3394-8. PMID 8622946 DOI: 10.1073/Pnas.93.8.3394  0.421
1996 de Graaf D, Sharma RC, Mechetner EB, Schimke RT, Roninson IB. P-glycoprotein confers methotrexate resistance in 3T6 cells with deficient carrier-mediated methotrexate uptake. Proceedings of the National Academy of Sciences of the United States of America. 93: 1238-42. PMID 8577747 DOI: 10.1073/Pnas.93.3.1238  0.373
1995 Urbani L, Sherwood SW, Schimke RT. Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization. Experimental Cell Research. 219: 159-68. PMID 7628532 DOI: 10.1006/Excr.1995.1216  0.379
1995 Sherwood SW, Schimke RT. Cell cycle analysis of apoptosis using flow cytometry. Methods in Cell Biology. 46: 77-97. PMID 7609661 DOI: 10.1016/S0091-679X(08)61925-1  0.334
1995 Ziv Y, Bar-Shira A, Jorgensen TJ, Russell PS, Sartiel A, Shows TB, Eddy RL, Buchwald M, Legerski R, Schimke RT, Shiloh Y. Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells. Somatic Cell and Molecular Genetics. 21: 99-111. PMID 7570189 DOI: 10.1007/Bf02255785  0.375
1994 Sherwood SW, Rush DF, Kung AL, Schimke RT. Cyclin B1 expression in HeLa S3 cells studied by flow cytometry. Experimental Cell Research. 211: 275-81. PMID 8143773 DOI: 10.1006/Excr.1994.1087  0.332
1994 Sherwood SW, Sheridan JP, Schimke RT. Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells. Experimental Cell Research. 215: 373-9. PMID 7982475 DOI: 10.1006/Excr.1994.1354  0.332
1994 Schimke RT, Kung A, Sherwood SS, Sheridan J, Sharma R. Life, death and genomic change in perturbed cell cycles. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 345: 311-7. PMID 7846128 DOI: 10.1098/Rstb.1994.0111  0.332
1994 Sharma RC, Schimke RT. The propensity for gene amplification: a comparison of protocols, cell lines, and selection agents. Mutation Research. 304: 243-60. PMID 7506368 DOI: 10.1016/0027-5107(94)90217-8  0.416
1993 Sherwood SW, Kung AL, Roitelman J, Simoni RD, Schimke RT. In vivo inhibition of cyclin B degradation and induction of cell-cycle arrest in mammalian cells by the neutral cysteine protease inhibitor N-acetylleucylleucylnorleucinal. Proceedings of the National Academy of Sciences of the United States of America. 90: 3353-7. PMID 8386372 DOI: 10.1073/Pnas.90.8.3353  0.337
1993 Hoy CA, Carswell C, Schimke RT. Bromodeoxyuridine/DNA analysis of replication in CHO cells after exposure to UV light. Mutation Research. 290: 217-30. PMID 7694113 DOI: 10.1016/0027-5107(93)90162-9  0.342
1992 Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. 1978. Biotechnology (Reading, Mass.). 24: 397-410. PMID 1422048  0.494
1992 Chang AC, Nunberg JN, Kaufman RJ, Erlich HA, Schimke RT, Cohen SN. Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. 1978. Biotechnology (Reading, Mass.). 24: 330-6. PMID 1422034  0.418
1992 Spack EG, Lewis ED, Paradowski B, Schimke RT, Jones PP. Temporal order of DNA replication in the H-2 major histocompatibility complex of the mouse. Molecular and Cellular Biology. 12: 5174-88. PMID 1406689 DOI: 10.1128/Mcb.12.11.5174  0.389
1992 Swirski RA, Van Den Berg D, Murphy AJM, Lambert CM, Friedberg EC, Schimke RT. Improvements in the Epstein-Barr-based shuttle vector system for direct cloning in human tissue culture cells Methods. 4: 133-142. DOI: 10.1016/1046-2023(92)90045-A  0.411
1992 Murphy AJM, Kung AL, Swirski RA, Schimke RT. cDNA expression cloning in human cells using the pλDR2 episomal vector system Methods. 4: 111-131. DOI: 10.1016/1046-2023(92)90044-9  0.344
1991 Gallie DR, Feder JN, Schimke RT, Walbot V. Functional analysis of the tobacco mosaic virus tRNA-like structure in cytoplasmic gene regulation. Nucleic Acids Research. 19: 5031-6. PMID 1923770 DOI: 10.1093/Nar/19.18.5031  0.326
1991 Gallie DR, Feder JN, Schimke RT, Walbot V. Post-transcriptional regulation in higher eukaryotes: the role of the reporter gene in controlling expression. Molecular & General Genetics : Mgg. 228: 258-64. PMID 1886610 DOI: 10.1007/Bf00282474  0.396
1991 Schimke RT, Kung AL, Rush DF, Sherwood SW. Differences in mitotic control among mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 56: 417-25. PMID 1819503 DOI: 10.1101/Sqb.1991.056.01.049  0.311
1990 Ellsworth JL, Schimke RT. On the frequency of metaphase chromosome aberrations in the small intestine of aged rats. Journal of Gerontology. 45: B94-100. PMID 2335718 DOI: 10.1093/Geronj/45.3.B94  0.327
1990 Feder JN, Guidos CJ, Kusler B, Carswell C, Lewis D, Schimke RT. A cell cycle analysis of growth-related genes expressed during T lymphocyte maturation. The Journal of Cell Biology. 111: 2693-701. PMID 2277081 DOI: 10.1083/Jcb.111.6.2693  0.442
1990 Hoy CA, Lewis ED, Schimke RT. Perturbation of DNA replication and cell cycle progression by commonly used [3H]thymidine labeling protocols. Molecular and Cellular Biology. 10: 1584-92. PMID 2181279 DOI: 10.1128/Mcb.10.4.1584  0.335
1990 Serrano EE, Schimke RT. Flow cytometric analysis of mammalian glial cultures treated with methotrexate. Glia. 3: 539-49. PMID 2148556 DOI: 10.1002/Glia.440030613  0.737
1989 Abrams JM, Schimke RT. Chimeric 3-hydroxy-3-methylglutaryl coenzyme A reductase-dihydrofolate reductase genes display bidirectional expression and unidirectional regulation in stably transfected cells. Molecular and Cellular Biology. 9: 620-8. PMID 2710119  0.667
1989 Schimke RT. The discovery of gene amplification in mammalian cells: to be in the right place at the right time. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 11: 69-73. PMID 2686627 DOI: 10.1002/Bies.950110208  0.332
1989 Abrams JM, Schimke RT. Deletion of stably integrated DNA is suppressed by cadmium and zinc. Proceedings of the National Academy of Sciences of the United States of America. 86: 9380-4. PMID 2594774 DOI: 10.1073/Pnas.86.23.9380  0.665
1989 Feder JN, Assaraf YG, Seamer LC, Schimke RT. The pattern of dihydrofolate reductase expression through the cell cycle in rodent and human cultured cells. The Journal of Biological Chemistry. 264: 20583-90. PMID 2584230  0.302
1989 Hoy CA, Seamer LC, Schimke RT. Thermal denaturation of DNA for immunochemical staining of incorporated bromodeoxyuridine (BrdUrd): critical factors that affect the amount of fluorescence and the shape of BrdUrd/DNA histogram. Cytometry. 10: 718-25. PMID 2582962 DOI: 10.1002/Cyto.990100608  0.311
1989 Assaraf YG, Molina A, Schimke RT. Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. Journal of the National Cancer Institute. 81: 290-4. PMID 2521520 DOI: 10.1093/Jnci/81.4.290  0.352
1989 Sherwood SW, Atkinson RC, Schimke RT, Loher W. Flow-cytometric analysis of spermatogenesis in Teleogryllus commodus Journal of Insect Physiology. 35: 975-980. DOI: 10.1016/0022-1910(89)90021-8  0.334
1988 Sherwood SW, Schumacher RI, Schimke RT. Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis. Molecular and Cellular Biology. 8: 2822-7. PMID 3405220 DOI: 10.1128/Mcb.8.7.2822  0.381
1988 Sherwood SW, Rush D, Ellsworth JL, Schimke RT. Defining cellular senescence in IMR-90 cells: a flow cytometric analysis. Proceedings of the National Academy of Sciences of the United States of America. 85: 9086-90. PMID 3194411 DOI: 10.1073/Pnas.85.23.9086  0.36
1987 Roos DS, Schimke RT. Toxicity of folic acid analogs in cultured human cells: a microtiter assay for the analysis of drug competition. Proceedings of the National Academy of Sciences of the United States of America. 84: 4860-4. PMID 3496598 DOI: 10.1073/Pnas.84.14.4860  0.367
1987 Assaraf YG, Schimke RT. Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry. Proceedings of the National Academy of Sciences of the United States of America. 84: 7154-8. PMID 3478688 DOI: 10.1073/Pnas.84.20.7154  0.381
1987 Schimke RT, Roos DS, Brown PC. Amplification of genes in somatic mammalian cells. Methods in Enzymology. 151: 85-104. PMID 3431456 DOI: 10.1016/S0076-6879(87)51010-2  0.326
1987 Hoy CA, Rice GC, Kovacs M, Schimke RT. Over-replication of DNA in S phase Chinese hamster ovary cells after DNA synthesis inhibition. The Journal of Biological Chemistry. 262: 11927-34. PMID 3114256  0.306
1987 Rice GC, Ling V, Schimke RT. Frequencies of independent and simultaneous selection of Chinese hamster cells for methotrexate and doxorubicin (adriamycin) resistance. Proceedings of the National Academy of Sciences of the United States of America. 84: 9261-4. PMID 2892197 DOI: 10.1073/Pnas.84.24.9261  0.334
1987 Feder JN, Bowcock A, Cavalli-Sforza LL, Schimke RT. Two RFLPs for the human dihydrofolate reductase gene (DHFR). Nucleic Acids Research. 15: 5906. PMID 2886981 DOI: 10.1093/Nar/15.14.5906  0.33
1986 Dynan WS, Sazer S, Tjian R, Schimke RT. Transcription factor Sp1 recognizes a DNA sequence in the mouse dihydrofolate reductase promoter. Nature. 319: 246-8. PMID 3945313 DOI: 10.1038/319246A0  0.363
1986 Farnham PJ, Schimke RT. In vitro transcription and delimitation of promoter elements of the murine dihydrofolate reductase gene. Molecular and Cellular Biology. 6: 2392-401. PMID 3785199 DOI: 10.1128/Mcb.6.7.2392  0.618
1986 Farnham PJ, Schimke RT. Murine dihydrofolate reductase transcripts through the cell cycle. Molecular and Cellular Biology. 6: 365-71. PMID 3785152 DOI: 10.1128/Mcb.6.2.365  0.635
1986 Gasser CS, Schimke RT. Cell cycle regulation of transfected murine dihydrofolate reductase genes. The Journal of Biological Chemistry. 261: 6938-46. PMID 3700422  0.348
1986 Rice GC, Hoy C, Schimke RT. Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 5978-82. PMID 3461470 DOI: 10.1073/Pnas.83.16.5978  0.413
1986 Schimke RT, Sherwood SW, Hill AB, Johnston RN. Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications. Proceedings of the National Academy of Sciences of the United States of America. 83: 2157-61. PMID 3457380 DOI: 10.1073/Pnas.83.7.2157  0.304
1986 Johnston RN, Feder J, Hill AB, Sherwood SW, Schimke RT. Transient inhibition of DNA synthesis results in increased dihydrofolate reductase synthesis and subsequent increased DNA content per cell. Molecular and Cellular Biology. 6: 3373-81. PMID 3099164 DOI: 10.1128/mcb.6.10.3373-3381.1986  0.403
1985 Hill AB, Schimke RT. Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations. Cancer Research. 45: 5050-7. PMID 4027984  0.313
1985 Schimke RT, Hill A, Johnston RN. Fifth Gordon Hamilton-Fairley memorial lecture. Methotrexate resistance and gene amplification: an experimental model for the generation of cellular heterogeneity. British Journal of Cancer. 51: 459-65. PMID 3978027  0.354
1985 Hamkalo BA, Farnham PJ, Johnston R, Schimke RT. Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line. Proceedings of the National Academy of Sciences of the United States of America. 82: 1126-30. PMID 3856243 DOI: 10.1073/Pnas.82.4.1126  0.56
1985 Deschatrette J, Fougere-Deschatrette C, Corcos L, Schimke RT. Expression of the mouse serum albumin gene introduced into differentiated and dedifferentiated rat hepatoma cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 765-9. PMID 3856230 DOI: 10.1073/Pnas.82.3.765  0.43
1985 Skalnik DG, Brown DA, Brown PC, Friedman RL, Hardeman EC, Schimke RT, Simoni RD. Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines. The Journal of Biological Chemistry. 260: 1991-4. PMID 3838302  0.313
1985 Farnham PJ, Schimke RT. Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle. The Journal of Biological Chemistry. 260: 7675-80. PMID 2987264  0.575
1985 McGrogan M, Simonsen CC, Smouse DT, Farnham PJ, Schimke RT. Heterogeneity at the 5' termini of mouse dihydrofolate reductase mRNAs. Evidence for multiple promoter regions. The Journal of Biological Chemistry. 260: 2307-14. PMID 2982814  0.584
1985 Farnham PJ, Abrams JM, Schimke RT. Opposite-strand RNAs from the 5' flanking region of the mouse dihydrofolate reductase gene. Proceedings of the National Academy of Sciences of the United States of America. 82: 3978-82. PMID 2408272 DOI: 10.1073/Pnas.82.12.3978  0.725
1984 Tlsty TD, Brown PC, Schimke RT. UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Molecular and Cellular Biology. 4: 1050-6. PMID 6738530 DOI: 10.1128/Mcb.4.6.1050  0.407
1984 Mariani BD, Schimke RT. Gene amplification in a single cell cycle in Chinese hamster ovary cells. The Journal of Biological Chemistry. 259: 1901-10. PMID 6693439  0.359
1984 Griffith JK, Cram LS, Crawford BD, Jackson PJ, Schilling J, Schimke RT, Walters RA, Wilder ME, Jett JH. Construction and analysis of DNA sequence libraries from flow-sorted chromosomes: practical and theoretical considerations. Nucleic Acids Research. 12: 4019-34. PMID 6587323 DOI: 10.1093/Nar/12.9.4019  0.351
1984 Horns RC, Dower WJ, Schimke RT. Gene amplification in a leukemic patient treated with methotrexate. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2: 2-7. PMID 6583327  0.363
1984 Beverley SM, Coderre JA, Santi DV, Schimke RT. Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell. 38: 431-9. PMID 6467372 DOI: 10.1016/0092-8674(84)90498-7  0.592
1984 Schimke RT. Gene amplification in cultured animal cells. Cell. 37: 705-13. PMID 6378386 DOI: 10.1016/0092-8674(84)90406-9  0.399
1984 Schimke RT, Beverley S, Brown P, Cassin R, Federspiel N, Gasser C, Hill A, Johnston R, Mariani B, Mosse E. Gene amplification and drug resistance in cultured animal cells. Cancer Treatment Reviews. 11: 9-17. PMID 6375865 DOI: 10.1016/0305-7372(84)90038-0  0.608
1984 Federspiel NA, Beverley SM, Schilling JW, Schimke RT. Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification. The Journal of Biological Chemistry. 259: 9127-40. PMID 6086622  0.349
1983 Brown PC, Tlsty TD, Schimke RT. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Molecular and Cellular Biology. 3: 1097-107. PMID 6877240 DOI: 10.1128/Mcb.3.6.1097  0.432
1983 Johnston RN, Beverley SM, Schimke RT. Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. Proceedings of the National Academy of Sciences of the United States of America. 80: 3711-5. PMID 6574509 DOI: 10.1073/Pnas.80.12.3711  0.609
1983 Coderre JA, Beverley SM, Schimke RT, Santi DV. Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proceedings of the National Academy of Sciences of the United States of America. 80: 2132-6. PMID 6572966 DOI: 10.1073/Pnas.80.8.2132  0.571
1983 Feagin JE, Setzer DR, Schimke RT. A family of repeated DNA sequences, one of which resides in the second intervening sequence of the mouse dihydrofolate reductase gene. The Journal of Biological Chemistry. 258: 2480-7. PMID 6185497  0.7
1982 Haber DA, Schimke RT. Chromosome-mediated transfer and amplification of an altered mouse dihydrofolate reductase gene. Somatic Cell Genetics. 8: 499-508. PMID 7123452 DOI: 10.1007/Bf01538710  0.57
1982 Schimke RT, Brown PC, Kaufman RJ. Gene amplification and drug resistance in mammalian cells. National Cancer Institute Monograph. 60: 79-86. PMID 7121575  0.576
1982 Gasser CS, Simonsen CC, Schilling JW, Schimke RT. Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 6522-6. PMID 6959133 DOI: 10.1073/Pnas.79.21.6522  0.45
1982 Crouse GF, Simonsen CC, McEwan RN, Schimke RT. Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells. The Journal of Biological Chemistry. 257: 7887-97. PMID 6282858  0.325
1982 Burr HE, Schimke RT. Reduced-stringency DNA reassociation: sequence specific duplex formation. Nucleic Acids Research. 10: 719-33. PMID 6278429 DOI: 10.1093/Nar/10.2.719  0.306
1982 Setzer DR, McGrogan M, Schimke RT. Nucleotide sequence surrounding multiple polyadenylation sites in the mouse dihydrofolate reductase gene. The Journal of Biological Chemistry. 257: 5143-7. PMID 6121807  0.707
1981 Kaufman RJ, Brown PC, Schimke RT. Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. Molecular and Cellular Biology. 1: 1084-93. PMID 7346713 DOI: 10.1128/Mcb.1.12.1084  0.588
1981 Kaufman RJ, Schimke RT. Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line. Molecular and Cellular Biology. 1: 1069-76. PMID 7346712  0.527
1981 Haber DA, Schimke RT. Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes. Cell. 26: 355-62. PMID 7326744 DOI: 10.1016/0092-8674(81)90204-X  0.564
1981 Haber DA, Beverley SM, Kiely ML, Schimke RT. Properties of an altered dihydrofolate reductase encoded by amplified genes in cultured mouse fibroblasts. The Journal of Biological Chemistry. 256: 9501-10. PMID 7287696  0.465
1981 Mariani BD, Slate DL, Schimke RT. S phase-specific synthesis of dihydrofolate reductase in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 4985-9. PMID 6946445 DOI: 10.1073/Pnas.78.8.4985  0.363
1981 Schimke RT, Brown PC, Kaufman RJ, McGrogan M, Slate DL. Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 45: 785-97. PMID 6942951 DOI: 10.1101/Sqb.1981.045.01.097  0.554
1981 Brown PC, Beverley SM, Schimke RT. Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines. Molecular and Cellular Biology. 1: 1077-83. PMID 6287217 DOI: 10.1128/Mcb.1.12.1077  0.614
1980 Setzer DR, McGrogan M, Nunberg JH, Schimke RT. Size heterogeneity in the 3' end of dihydrofolate reductase messenger RNAs in mouse cells. Cell. 22: 361-70. PMID 7448865 DOI: 10.1016/0092-8674(80)90346-3  0.727
1980 Burr HE, Schimke RT. Intragenomic DNA sequence homologies in the chicken and other members of the class Aves: DNA re-association under reduced stringency conditions. Journal of Molecular Evolution. 15: 291-307. PMID 7411652 DOI: 10.1007/Bf01733136  0.31
1980 Schimke RT. Gene amplification and methotrexate resistance in cultured animal cells. Harvey Lectures. 76: 1-25. PMID 7129861  0.306
1980 Nunberg JH, Kaufman RJ, Chang AC, Cohen SN, Schimke RT. Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell. 19: 355-64. PMID 6244105 DOI: 10.1016/0092-8674(80)90510-3  0.567
1980 Chang AC, Erlich HA, Gunsalus RP, Nunberg JH, Kaufman RJ, Schimke RT, Cohen SN. Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence. Proceedings of the National Academy of Sciences of the United States of America. 77: 1442-6. PMID 6154933 DOI: 10.1073/Pnas.77.3.1442  0.543
1979 Payvar F, Schimke RT. Improvements in immunoprecipitation of specific messenger RNA. Isolation of highly purified conalbumin mRNA in high yield. European Journal of Biochemistry / Febs. 101: 271-82. PMID 510310 DOI: 10.1111/J.1432-1033.1979.Tb04240.X  0.324
1979 Dolnick BJ, Berenson RJ, Bertino JR, Kaufman RJ, Nunberg JH, Schimke RT. Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. The Journal of Cell Biology. 83: 394-402. PMID 500787 DOI: 10.1083/Jcb.83.2.394  0.599
1979 Stark GR, Dower WJ, Schimke RT, Brown RE, Kerr IM. 2-5A synthetase: assay, distribution and variation with growth or hormone status. Nature. 278: 471-3. PMID 450053 DOI: 10.1038/278471A0  0.337
1979 Buell GN, Wickens MP, Carbon J, Schimke RT. Isolation of recombinant plasmids bearing cDNA to hen ovomucoid and lysozyme mRNAs. The Journal of Biological Chemistry. 254: 9277-83. PMID 383714  0.535
1979 Wickens MP, Buell GN, Crouse GF, Carbon J, Schimke RT. Restriction map of the region surrounding the EcoRI site in the pCR1 plasmid and analysis of an inserted ovalbumin gene. Gene. 5: 19-43. PMID 372047 DOI: 10.1016/0378-1119(79)90090-8  0.572
1979 Kaufman RJ, Brown PC, Schimke RT. Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 76: 5669-73. PMID 293670 DOI: 10.1073/Pnas.76.11.5669  0.599
1979 Schimke RT, Kaufman RJ, Nunberg JH, Dana SL. Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 43: 1297-303. PMID 290443 DOI: 10.1101/Sqb.1979.043.01.148  0.581
1979 Hughes SH, Stubblefield E, Payvar F, Engel JD, Dodgson JB, Spector D, Cordell B, Schimke RT, Varmus HE. Gene localization by chromosome fractionation: globin genes are on at least two chromosomes and three estrogen-inducible genes are on three chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 76: 1348-52. PMID 286316 DOI: 10.1073/Pnas.76.3.1348  0.382
1979 Hughes SH, Payvar F, Spector D, Schimke RT, Robinson HL, Payne GS, Bishop JM, Varmus HE. Heterogeneity of genetic loci in chickens: analysis of endogenous viral and nonviral genes by cleavage of DNA with restriction endonucleases. Cell. 18: 347-59. PMID 227605 DOI: 10.1016/0092-8674(79)90054-0  0.385
1979 Kellems RE, Morhenn VB, Pfendt EA, Alt FW, Schimke RT. Polyoma virus and cyclic AMP-mediated control of dihydrofolate reductase mRNA abundance in methotrexate-resistant mouse fibroblasts. The Journal of Biological Chemistry. 254: 309-18. PMID 216671  0.486
1979 Schimke RT, Brown P, Kaufman R. Gene amplification and methotrexate resistance in cultured mammalian cells Journal of Supramolecular and Cellular Biochemistry. 092.  0.322
1978 Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science (New York, N.Y.). 202: 1051-5. PMID 715457 DOI: 10.1126/Science.715457  0.626
1978 Pennequin P, Robins DM, Schimke RT. Regulation of translation of ovalbumin messenger RNA by estrogens and progesterone in oviduct of withdrawn chicks. European Journal of Biochemistry / Febs. 90: 51-8. PMID 710420 DOI: 10.1111/J.1432-1033.1978.Tb12573.X  0.34
1978 Kaufman RJ, Bertino JR, Schimke RT. Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter. The Journal of Biological Chemistry. 253: 5852-60. PMID 670236  0.43
1978 Buell GN, Wickens MP, Payvar F, Schimke RT. Synthesis of full length cDNAs from four partially purified oviduct mRNAs. The Journal of Biological Chemistry. 253: 2471-82. PMID 632280  0.509
1978 Alt FW, Kellems RE, Bertino JR, Schimke RT. Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells. The Journal of Biological Chemistry. 253: 1357-70. PMID 627542  0.494
1978 Chang AC, Nunberg JH, Kaufman RJ, Erlich HA, Schimke RT, Cohen SN. Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature. 275: 617-24. PMID 360074 DOI: 10.1038/275617A0  0.539
1978 Nunberg JH, Kaufman RJ, Schimke RT, Urlaub G, Chasin LA. Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proceedings of the National Academy of Sciences of the United States of America. 75: 5553-6. PMID 281704 DOI: 10.1073/Pnas.75.11.5553  0.604
1978 Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR. Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 649-57. PMID 277312 DOI: 10.1101/Sqb.1978.042.01.067  0.652
1978 Nakanishi S, Inoue A, Kita T, Numa S, Chang AC, Cohen SN, Nunberg J, Schimke RT. Construction of bacterial plasmids that contain the nucleotide sequence for bovine corticotropin-beta-lipotropin precursor. Proceedings of the National Academy of Sciences of the United States of America. 75: 6021-5. PMID 216007 DOI: 10.1073/Pnas.75.12.6021  0.315
1978 Wickens MP, Buell GN, Schimke RT. Synthesis of double-stranded DNA complementary to lysozyme, ovomucoid, and ovalbumin mRNAs. Optimization for full length second strand synthesis by Escherichia coli DNA polymerase I. The Journal of Biological Chemistry. 253: 2483-95. PMID 75887  0.522
1976 Anderson JN, Schimke RT. Partial purification of the ovalbumin gene. Cell. 7: 331-8. PMID 985737 DOI: 10.1016/0092-8674(76)90162-8  0.378
1976 Alt FW, Kellems RE, Schimke RT. Synthesis and degradation of folate reductase in sensitive and methotrexate-resistant lines of S-180 cells. The Journal of Biological Chemistry. 251: 3063-74. PMID 944697  0.462
1976 Kellems RE, Alt FW, Schimke RT. Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA. The Journal of Biological Chemistry. 251: 6987-93. PMID 62753  0.497
1975 Schimke RT, Shapiro DJ, McKnight GS. Ovalbumin mRNA and ovalbumin DNA and the molecular biology of steroid hormone action. Advances in Experimental Medicine and Biology. 62: 79-101. PMID 1106137 DOI: 10.1007/978-1-4684-3255-8_6  0.32
1974 McKnight GS, Schimke RT. Ovalbumin messenger RNA: evidence that the initial product of transcription is the same size as polysomal ovalbumin messenger. Proceedings of the National Academy of Sciences of the United States of America. 71: 4327-31. PMID 4530986 DOI: 10.1073/Pnas.71.11.4327  0.35
1973 Schimke RT, Palacios R, Palmiter RD, Rhoads RE. Hormonal regulation of ovalbumin synthesis in chick oviduct. Basic Life Sciences. 1: 123-35. PMID 4797927 DOI: 10.1007/978-1-4684-0877-5_10  0.6
1973 Palmiter RD, Schimke RT. Regulation of protein synthesis in chick oviduct. 3. Mechanism of ovalbumin "superinduction" by actinomycin D. The Journal of Biological Chemistry. 248: 1502-12. PMID 4694721  0.505
1972 Mellman WJ, Schimke RT, Hayflick L. Catalase turnover in human diploid cell cultures. Experimental Cell Research. 73: 399-409. PMID 5066244 DOI: 10.1016/0014-4827(72)90064-X  0.301
1972 Palmiter RD, Palacios R, Schimke RT. Identification and isolation of ovalbumin-synthesizing polysomes. II. Quantification and immunoprecipitation of polysomes. The Journal of Biological Chemistry. 247: 3296-304. PMID 4112809  0.495
1972 Palacios R, Palmiter RD, Schimke RT. Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes. The Journal of Biological Chemistry. 247: 2316-21. PMID 4111967  0.503
1971 Palmiter RD, Oka T, Schimke RT. Modulation of ovalbumin synthesis by estradiol-17 beta and actinomycin D as studied in explants of chick oviduct in culture. The Journal of Biological Chemistry. 246: 724-37. PMID 5542686  0.505
1970 Palmiter RD, Christensen AK, Schimke RT. Organization of polysomes from pre-existing ribosomes in chick oviduct by a secondary administration of either estradiol or progesterone. The Journal of Biological Chemistry. 245: 833-45. PMID 5416666  0.499
1969 Oka T, Schimke RT. Interaction of estrogen and progesterone in chick oviduct development. I. Antagonistic effect of progesterone on estrogen-induced proliferation and differentiation of tubular gland cells. The Journal of Cell Biology. 41: 816-31. PMID 5814004 DOI: 10.1083/Jcb.41.3.816  0.336
1969 Oka T, Schimke RT. Progesterone antagonism of estrogen-induced cytodifferentiation in chick oviduct. Science (New York, N.Y.). 163: 83-5. PMID 5763496 DOI: 10.1126/Science.163.3862.83  0.322
1969 Oka T, Schimke RT. Interaction of estrogen and progesterone in chick oviduct development. II. Effects of estrogen and progesterone on tubular gland cell function. The Journal of Cell Biology. 43: 123-37. PMID 5350180 DOI: 10.1083/Jcb.43.1.123  0.347
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