H. Steve White, Ph.D. - Publications

Pharmacology and Toxicology University of Utah, Salt Lake City, UT 
Epilepsy, anticonvulsant drugs

193 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Metcalf CS, Huntsman M, Garcia G, Kochanski AK, Chikinda M, Watanabe E, Underwood T, Vanegas F, Smith MD, White HS, Bulaj G. Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs. Frontiers in Neurology. 10: 277. PMID 30972009 DOI: 10.3389/fneur.2019.00277  0.64
2019 Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Tomson T, White HS. Virtual special issue "Neuromodulation": A summary of data presented at the XIV conference on new antiepileptic drug and devices (EILAT XIV). Epilepsy Research. PMID 30910314 DOI: 10.1016/j.eplepsyres.2019.03.002  0.32
2019 Hill AC, Thomson KE, Newell TG, White HS. Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence. Epilepsia. PMID 30669183 DOI: 10.1111/epi.14655  0.36
2018 Rho JM, White HS. Brief history of anti-seizure drug development. Epilepsia Open. 3: 114-119. PMID 30564769 DOI: 10.1002/epi4.12268  0.88
2018 Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development. Epilepsia. 59: 1811-1841. PMID 30368792 DOI: 10.1111/epi.14557  0.32
2018 Bialer M, Johannessen SI, Koepp MJ, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development. Epilepsia. 59: 1842-1866. PMID 30368788 DOI: 10.1111/epi.14555  0.32
2018 West PJ, Saunders GW, Billingsley P, Smith MD, White HS, Metcalf CS, Wilcox KS. Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs. Epilepsia. PMID 30328622 DOI: 10.1111/epi.14563  0.96
2017 Barker-Haliski ML, Löscher W, White HS, Galanopoulou AS. Neuroinflammation in epileptogenesis: Insights and translational perspectives from new models of epilepsy. Epilepsia. 58: 39-47. PMID 28675559 DOI: 10.1111/epi.13785  0.44
2017 Metcalf CS, West PJ, Thomson KE, Edwards SF, Smith MD, White HS, Wilcox KS. Development and pharmacologic characterization of the rat 6 Hz model of partial seizures. Epilepsia. PMID 28449218 DOI: 10.1111/epi.13764  0.96
2017 Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII). Epilepsia. PMID 28111749 DOI: 10.1111/epi.13634  0.32
2016 Barker-Haliski ML, Heck TD, Dahle EJ, Vanegas F, Pruess TH, Wilcox KS, White HS. Acute treatment with minocycline, but not valproic acid, improves long-term behavioral outcomes in the Theiler's virus model of temporal lobe epilepsy. Epilepsia. PMID 27739576 DOI: 10.1111/epi.13577  0.96
2016 Loewen JL, Barker-Haliski ML, Dahle EJ, White HS, Wilcox KS. Neuronal Injury, Gliosis, and Glial Proliferation in Two Models of Temporal Lobe Epilepsy. Journal of Neuropathology and Experimental Neurology. PMID 26945036 DOI: 10.1093/jnen/nlw008  0.96
2016 Umpierre AD, Bennett IV, Nebeker LD, Newell TG, Tian BB, Thomson KE, White HS, White JA, Wilcox KS. Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures. Experimental Neurology. PMID 26896834 DOI: 10.1016/j.expneurol.2016.02.014  0.32
2016 Walls AB, Flynn SP, West PJ, Müller MS, Bak LK, Bulaj G, Schousboe A, White HS. The anticonvulsant action of the galanin receptor agonist NAX-5055 involves modulation of both excitatory- and inhibitory neurotransmission. Epilepsy Research. 121: 55-63. PMID 26894875 DOI: 10.1016/j.eplepsyres.2016.01.006  0.64
2015 Kaufmann D, Bates EA, Yagen B, Bialer M, Saunders GH, Wilcox K, White HS, Brennan KC. sec-Butylpropylacetamide (SPD) has antimigraine properties. Cephalalgia : An International Journal of Headache. PMID 26568161 DOI: 10.1177/0333102415612773  0.32
2015 Smeal RM, Fujinami R, White HS, Wilcox KS. Decrease in CA3 inhibitory network activity during Theiler's virus encephalitis. Neuroscience Letters. 609: 210-215. PMID 26477780 DOI: 10.1016/j.neulet.2015.10.032  0.96
2015 Vezzani A, Fujinami RS, White HS, Preux PM, Blümcke I, Sander JW, Löscher W. Infections, inflammation and epilepsy. Acta Neuropathologica. PMID 26423537 DOI: 10.1007/s00401-015-1481-5  0.32
2015 Barker-Haliski ML, Friedman D, French JA, White HS. Disease modification in epilepsy: from animal models to clinical applications. Drugs. 75: 749-67. PMID 25925798 DOI: 10.1007/s40265-015-0395-9  0.96
2015 Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII). Epilepsy Research. 111: 85-141. PMID 25769377 DOI: 10.1016/j.eplepsyres.2015.01.001  0.96
2015 Barker-Haliski ML, Dahle EJ, Heck TD, Pruess TH, Vanegas F, Wilcox KS, White HS. Evaluating an etiologically relevant platform for therapy development for temporal lobe epilepsy: effects of carbamazepine and valproic acid on acute seizures and chronic behavioral comorbidities in the Theiler's murine encephalomyelitis virus mouse model. The Journal of Pharmacology and Experimental Therapeutics. 353: 318-29. PMID 25755209 DOI: 10.1124/jpet.114.222513  0.96
2015 Lee HK, Zhang L, Smith MD, Walewska A, Vellore NA, Baron R, McIntosh JM, White HS, Olivera BM, Bulaj G. A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties. Frontiers in Pharmacology. 6: 11. PMID 25713532 DOI: 10.3389/fphar.2015.00011  0.96
2015 Flynn SP, White HS. Regulation of glucose and insulin release following acute and repeated treatment with the synthetic galanin analog NAX-5055. Neuropeptides. 50: 35-42. PMID 25690510 DOI: 10.1016/j.npep.2015.01.001  0.96
2015 Metcalf CS, Klein BD, McDougle DR, Zhang L, Smith MD, Bulaj G, White HS. Analgesic properties of a peripherally acting and GalR2 receptor-preferring galanin analog in inflammatory, neuropathic, and acute pain models. The Journal of Pharmacology and Experimental Therapeutics. 352: 185-93. PMID 25347995 DOI: 10.1124/jpet.114.219063  0.96
2014 Barker-Haliski M, Friedman D, White HS, French JA. How clinical development can, and should, inform translational science. Neuron. 84: 582-93. PMID 25442937 DOI: 10.1016/j.neuron.2014.10.029  0.96
2014 Thomson KE, White HS. A novel open-source drug-delivery system that allows for first-of-kind simulation of nonadherence to pharmacological interventions in animal disease models. Journal of Neuroscience Methods. 238: 105-11. PMID 25256646 DOI: 10.1016/j.jneumeth.2014.09.019  0.96
2014 Barker-Haliski M, Sills GJ, White HS. What are the arguments for and against rational therapy for epilepsy? Advances in Experimental Medicine and Biology. 813: 295-308. PMID 25012386 DOI: 10.1007/978-94-017-8914-1_24  0.96
2014 Schousboe A, Madsen KK, Barker-Haliski ML, White HS. The GABA synapse as a target for antiepileptic drugs: a historical overview focused on GABA transporters. Neurochemical Research. 39: 1980-7. PMID 24627365 DOI: 10.1007/s11064-014-1263-9  0.96
2014 West PJ, Saunders GW, Remigio GJ, Wilcox KS, White HS. Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice. Epilepsia. 55: 214-23. PMID 24447124 DOI: 10.1111/epi.12524  0.96
2014 White HS, Löscher W. Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategies. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 373-84. PMID 24425186 DOI: 10.1007/s13311-013-0250-1  0.96
2014 Umpierre AD, Remigio GJ, Dahle EJ, Bradford K, Alex AB, Smith MD, West PJ, White HS, Wilcox KS. Impaired cognitive ability and anxiety-like behavior following acute seizures in the Theiler's virus model of temporal lobe epilepsy. Neurobiology of Disease. 64: 98-106. PMID 24412221 DOI: 10.1016/j.nbd.2013.12.015  0.96
2014 Jequier Gygax M, Klein BD, White HS, Kim M, Galanopoulou AS. Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms. Epilepsy Research. 108: 98-108. PMID 24252685 DOI: 10.1016/j.eplepsyres.2013.10.015  0.96
2013 McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). Journal of Medicinal Chemistry. 56: 9019-30. PMID 24205976 DOI: 10.1021/jm400894u  0.96
2013 Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Moshé SL, Noebels JL, Privitera MD, Rogawski MA. Issues related to development of new antiseizure treatments. Epilepsia. 54: 24-34. PMID 23909851 DOI: 10.1111/epi.12296  0.96
2013 French JA, White HS, Klitgaard H, Holmes GL, Privitera MD, Cole AJ, Quay E, Wiebe S, Schmidt D, Porter RJ, Arzimanoglou A, Trinka E, Perucca E. Development of new treatment approaches for epilepsy: unmet needs and opportunities. Epilepsia. 54: 3-12. PMID 23909849 DOI: 10.1111/epi.12294  0.96
2013 Srivastava AK, Alex AB, Wilcox KS, White HS. Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: a novel experimental model of pharmacoresistant epilepsy. Epilepsia. 54: 1186-94. PMID 23750799 DOI: 10.1111/epi.12234  0.6
2013 Vogensen SB, Jørgensen L, Madsen KK, Borkar N, Wellendorph P, Skovgaard-Petersen J, Schousboe A, White HS, Krogsgaard-Larsen P, Clausen RP. Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. Journal of Medicinal Chemistry. 56: 2160-4. PMID 23398473 DOI: 10.1021/jm301872x  0.96
2013 Zhang L, Klein BD, Metcalf CS, Smith MD, McDougle DR, Lee HK, White HS, Bulaj G. Incorporation of monodisperse oligoethyleneglycol amino acids into anticonvulsant analogues of galanin and neuropeptide y provides peripherally acting analgesics. Molecular Pharmaceutics. 10: 574-85. PMID 23259957 DOI: 10.1021/mp300236v  0.96
2013 Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Research. 103: 2-30. PMID 23219031 DOI: 10.1016/j.eplepsyres.2012.10.001  0.96
2013 Srivastava AK, White HS. Carbamazepine, but not valproate, displays pharmacoresistance in lamotrigine-resistant amygdala kindled rats. Epilepsy Research. 104: 26-34. PMID 23158096 DOI: 10.1016/j.eplepsyres.2012.10.003  0.96
2012 Gowd KH, Han TS, Twede V, Gajewiak J, Smith MD, Watkins M, Platt RJ, Toledo G, White HS, Olivera BM, Bulaj G. Conantokins derived from the Asprella clade impart conRl-B, an N-methyl d-aspartate receptor antagonist with a unique selectivity profile for NR2B subunits. Biochemistry. 51: 4685-92. PMID 22594498 DOI: 10.1021/bi300055n  0.96
2012 Platt RJ, Han TS, Green BR, Smith MD, Skalicky J, Gruszczynski P, White HS, Olivera B, Bulaj G, Gajewiak J. Stapling mimics noncovalent interactions of γ-carboxyglutamates in conantokins, peptidic antagonists of N-methyl-D-aspartic acid receptors. The Journal of Biological Chemistry. 287: 20727-36. PMID 22518838 DOI: 10.1074/jbc.M112.350462  0.96
2012 Robertson CR, Pruess TH, Grussendorf E, White HS, Bulaj G. Generating orally active galanin analogues with analgesic activities. Chemmedchem. 7: 903-9. PMID 22374865 DOI: 10.1002/cmdc.201100574  0.96
2012 Rowley NM, Madsen KK, Schousboe A, Steve White H. Glutamate and GABA synthesis, release, transport and metabolism as targets for seizure control. Neurochemistry International. 61: 546-58. PMID 22365921 DOI: 10.1016/j.neuint.2012.02.013  0.44
2012 Smeal RM, Stewart KA, Iacob E, Fujinami RS, White HS, Wilcox KS. The activity within the CA3 excitatory network during Theiler's virus encephalitis is distinct from that observed during chronic epilepsy. Journal of Neurovirology. 18: 30-44. PMID 22328242 DOI: 10.1007/s13365-012-0082-5  0.96
2012 Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 53: 571-82. PMID 22292566 DOI: 10.1111/j.1528-1167.2011.03391.x  0.96
2012 Large CH, Sokal DM, Nehlig A, Gunthorpe MJ, Sankar R, Crean CS, Vanlandingham KE, White HS. The spectrum of anticonvulsant efficacy of retigabine (ezogabine) in animal models: implications for clinical use. Epilepsia. 53: 425-36. PMID 22221318 DOI: 10.1111/j.1528-1167.2011.03364.x  0.96
2012 White HS, Alex AB, Pollock A, Hen N, Shekh-Ahmad T, Wilcox KS, McDonough JH, Stables JP, Kaufmann D, Yagen B, Bialer M. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage. Epilepsia. 53: 134-46. PMID 22150444 DOI: 10.1111/j.1528-1167.2011.03338.x  0.96
2011 Green BR, Smith M, White KL, White HS, Bulaj G. Analgesic neuropeptide W suppresses seizures in the brain revealed by rational repositioning and peptide engineering. Acs Chemical Neuroscience. 2: 51-6. PMID 22826747 DOI: 10.1021/cn1000974  0.96
2011 Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS. Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6. Journal of Neurovirology. 17: 496-9. PMID 21833798 DOI: 10.1007/s13365-011-0050-5  0.96
2011 Brodie MJ, Covanis A, Gil-Nagel A, Lerche H, Perucca E, Sills GJ, White HS. Antiepileptic drug therapy: does mechanism of action matter? Epilepsy & Behavior : E&B. 21: 331-41. PMID 21763207 DOI: 10.1016/j.yebeh.2011.05.025  0.96
2011 Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS. Lack of correlation of central nervous system inflammation and neuropathology with the development of seizures following acute virus infection. Journal of Virology. 85: 8149-57. PMID 21680509 DOI: 10.1128/JVI.00730-11  0.6
2011 Simeone TA, Wilcox KS, White HS. cAMP-dependent protein kinase A activity modulates topiramate potentiation of GABA(A) receptors. Epilepsy Research. 96: 176-9. PMID 21665439 DOI: 10.1016/j.eplepsyres.2011.05.009  0.96
2011 Libbey JE, Kennett NJ, Wilcox KS, White HS, Fujinami RS. Interleukin-6, produced by resident cells of the central nervous system and infiltrating cells, contributes to the development of seizures following viral infection. Journal of Virology. 85: 6913-22. PMID 21543484 DOI: 10.1128/JVI.00458-11  0.96
2011 Lehre AC, Rowley NM, Zhou Y, Holmseth S, Guo C, Holen T, Hua R, Laake P, Olofsson AM, Poblete-Naredo I, Rusakov DA, Madsen KK, Clausen RP, Schousboe A, White HS, et al. Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice. Epilepsy Research. 95: 70-81. PMID 21459558 DOI: 10.1016/j.eplepsyres.2011.02.014  0.96
2011 Madsen KK, Ebert B, Clausen RP, Krogsgaard-Larsen P, Schousboe A, White HS. Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol. The Journal of Pharmacology and Experimental Therapeutics. 338: 214-9. PMID 21450931 DOI: 10.1124/jpet.111.179671  0.96
2011 Schousboe A, Madsen KK, White HS. GABA transport inhibitors and seizure protection: the past and future. Future Medicinal Chemistry. 3: 183-7. PMID 21428813 DOI: 10.4155/fmc.10.288  0.96
2011 Simeone TA, Wilcox KS, White HS. Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 64: 44-52. PMID 21421049 DOI: 10.1016/j.phrs.2011.03.004  0.96
2011 Robertson CR, Flynn SP, White HS, Bulaj G. Anticonvulsant neuropeptides as drug leads for neurological diseases. Natural Product Reports. 28: 741-62. PMID 21340067 DOI: 10.1039/c0np00048e  0.96
2011 Rowley NM, Smith MD, Lamb JG, Schousboe A, White HS. Hippocampal betaine/GABA transporter mRNA expression is not regulated by inflammation or dehydration post-status epilepticus. Journal of Neurochemistry. 117: 82-90. PMID 21219332 DOI: 10.1111/j.1471-4159.2011.07174.x  0.96
2011 Schousboe A, Madsen KK, White HS. Neurotransmitter transporters and anticonvulsant drug development Neuromethods. 56: 431-446. DOI: 10.1007/978-1-61779-077-5_22  0.96
2010 Stewart KA, Wilcox KS, Fujinami RS, White HS. Development of postinfection epilepsy after Theiler's virus infection of C57BL/6 mice. Journal of Neuropathology and Experimental Neurology. 69: 1210-9. PMID 21107134 DOI: 10.1097/NEN.0b013e3181ffc420  0.96
2010 Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Tenth Eilat Conference (EILAT X). Epilepsy Research. 92: 89-124. PMID 20970964 DOI: 10.1016/j.eplepsyres.2010.09.001  0.96
2010 Rowley NM, White HS. Comparative anticonvulsant efficacy in the corneal kindled mouse model of partial epilepsy: Correlation with other seizure and epilepsy models. Epilepsy Research. 92: 163-9. PMID 20951004 DOI: 10.1016/j.eplepsyres.2010.09.002  0.96
2010 Green BR, White KL, McDougle DR, Zhang L, Klein B, Scholl EA, Pruess TH, White HS, Bulaj G. Introduction of lipidization-cationization motifs affords systemically bioavailable neuropeptide Y and neurotensin analogs with anticonvulsant activities. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 486-95. PMID 20645434 DOI: 10.1002/psc.1266  0.96
2010 Libbey JE, Kirkman NJ, Wilcox KS, White HS, Fujinami RS. Role for complement in the development of seizures following acute viral infection. Journal of Virology. 84: 6452-60. PMID 20427530 DOI: 10.1128/JVI.00422-10  0.96
2010 Robertson CR, Scholl EA, Pruess TH, Green BR, White HS, Bulaj G. Engineering galanin analogues that discriminate between GalR1 and GalR2 receptor subtypes and exhibit anticonvulsant activity following systemic delivery. Journal of Medicinal Chemistry. 53: 1871-5. PMID 20121116 DOI: 10.1021/jm9018349  0.96
2010 Bialer M, White HS. Key factors in the discovery and development of new antiepileptic drugs. Nature Reviews. Drug Discovery. 9: 68-82. PMID 20043029 DOI: 10.1038/nrd2997  0.96
2010 Madsen KK, White HS, Schousboe A. Neuronal and non-neuronal GABA transporters as targets for antiepileptic drugs. Pharmacology & Therapeutics. 125: 394-401. PMID 20026354 DOI: 10.1016/j.pharmthera.2009.11.007  0.96
2010 Stewart KA, Wilcox KS, Fujinami RS, White HS. Theiler's virus infection chronically alters seizure susceptibility. Epilepsia. 51: 1418-28. PMID 20002148 DOI: 10.1111/j.1528-1167.2009.02405.x  0.96
2010 Kirkman NJ, Libbey JE, Wilcox KS, White HS, Fujinami RS. Innate but not adaptive immune responses contribute to behavioral seizures following viral infection. Epilepsia. 51: 454-64. PMID 19845729 DOI: 10.1111/j.1528-1167.2009.02390.x  0.96
2010 White HS. Animal models for evaluating antiepileptogenesis Epilepsia. 51: 87. DOI: 10.1111/j.1528-1167.2010.02873.x  0.96
2009 Singh NA, Pappas C, Dahle EJ, Claes LR, Pruess TH, De Jonghe P, Thompson J, Dixon M, Gurnett C, Peiffer A, White HS, Filloux F, Leppert MF. A role of SCN9A in human epilepsies, as a cause of febrile seizures and as a potential modifier of Dravet syndrome. Plos Genetics. 5: e1000649. PMID 19763161 DOI: 10.1371/journal.pgen.1000649  0.96
2009 Lee HK, Smith MD, Smith BJ, Grussendorf J, Xu L, Gillies RJ, White HS, Bulaj G. Anticonvulsant Met-enkephalin analogues containing backbone spacers reveal alternative non-opioid signaling in the brain. Acs Chemical Biology. 4: 659-71. PMID 19634861 DOI: 10.1021/cb900045c  0.96
2009 Henshall DC, Dürmüller N, White HS, Williams R, Moser P, Dunleavy M, Silverstone PH. Electroencephalographic and behavioral convulsant effects of hydrobromide and hydrochloride salts of bupropion in conscious rodents. Neuropsychiatric Disease and Treatment. 5: 189-206. PMID 19557114  0.96
2009 Statler KD, Scheerlinck P, Pouliot W, Hamilton M, White HS, Dudek FE. A potential model of pediatric posttraumatic epilepsy. Epilepsy Research. 86: 221-3. PMID 19520549 DOI: 10.1016/j.eplepsyres.2009.05.006  0.96
2009 Otto JF, Singh NA, Dahle EJ, Leppert MF, Pappas CM, Pruess TH, Wilcox KS, White HS. Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions. Epilepsia. 50: 1752-9. PMID 19453707 DOI: 10.1111/j.1528-1167.2009.02100.x  0.96
2009 Madsen KK, Clausen RP, Larsson OM, Krogsgaard-Larsen P, Schousboe A, White HS. Synaptic and extrasynaptic GABA transporters as targets for anti-epileptic drugs. Journal of Neurochemistry. 109: 139-44. PMID 19393020 DOI: 10.1111/j.1471-4159.2009.05982.x  0.36
2009 Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, et al. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. Journal of Medicinal Chemistry. 52: 7528-36. PMID 19388676 DOI: 10.1021/jm801432r  0.96
2009 White HS, Scholl EA, Klein BD, Flynn SP, Pruess TH, Green BR, Zhang L, Bulaj G. Developing novel antiepileptic drugs: characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 372-80. PMID 19332332 DOI: 10.1016/j.nurt.2009.01.001  0.96
2009 Zhang L, Lee HK, Pruess TH, White HS, Bulaj G. Synthesis and applications of polyamine amino acid residues: improving the bioactivity of an analgesic neuropeptide, neurotensin. Journal of Medicinal Chemistry. 52: 1514-7. PMID 19236044 DOI: 10.1021/jm801481y  0.96
2009 Zhang L, Robertson CR, Green BR, Pruess TH, White HS, Bulaj G. Structural requirements for a lipoamino acid in modulating the anticonvulsant activities of systemically active galanin analogues. Journal of Medicinal Chemistry. 52: 1310-6. PMID 19199479 DOI: 10.1021/jm801397w  0.96
2009 Lee HK, Zhang L, Smith MD, White HS, Bulaj G. Glycosylated neurotensin analogues exhibit sub-picomolar anticonvulsant potency in a pharmacoresistant model of epilepsy. Chemmedchem. 4: 400-5. PMID 19173215 DOI: 10.1002/cmdc.200800421  0.96
2009 Bialer M, Johannessen SI, Levy RH, Perucca E, Tomson T, White HS. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Research. 83: 1-43. PMID 19008076 DOI: 10.1016/j.eplepsyres.2008.09.005  0.96
2009 Singh NA, Otto JF, Leppert MF, White HS, Wilcox KS. Mouse models of benign familial neonatal convulsions (BFNC): Mutations in KCNQ (Kv7) genes Neuromethods. 40: 107-120. DOI: 10.1007/978-1-60327-263-6_7  0.96
2009 White HS. Antiepileptic Drug Discovery The Treatment of Epilepsy: Third Edition. 81-89. DOI: 10.1002/9781444316667.ch6  0.96
2008 Bulaj G, Green BR, Lee HK, Robertson CR, White K, Zhang L, Sochanska M, Flynn SP, Scholl EA, Pruess TH, Smith MD, White HS. Design, synthesis, and characterization of high-affinity, systemically-active galanin analogues with potent anticonvulsant activities. Journal of Medicinal Chemistry. 51: 8038-47. PMID 19053761 DOI: 10.1021/jm801088x  0.96
2008 Statler KD, Swank S, Abildskov T, Bigler ED, White HS. Traumatic brain injury during development reduces minimal clonic seizure thresholds at maturity. Epilepsy Research. 80: 163-70. PMID 18490145 DOI: 10.1016/j.eplepsyres.2008.04.001  0.96
2008 Singh NA, Otto JF, Dahle EJ, Pappas C, Leslie JD, Vilaythong A, Noebels JL, White HS, Wilcox KS, Leppert MF. Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. The Journal of Physiology. 586: 3405-23. PMID 18483067 DOI: 10.1113/jphysiol.2008.154971  0.6
2008 Foreman MM, Hanania T, Stratton SC, Wilcox KS, White HS, Stables JP, Eller M. In vivo pharmacological effects of JZP-4, a novel anticonvulsant, in models for anticonvulsant, antimania and antidepressant activity. Pharmacology, Biochemistry, and Behavior. 89: 523-34. PMID 18377968 DOI: 10.1016/j.pbb.2008.02.007  0.96
2008 White HS, Franklin MR, Kupferberg HJ, Schmutz M, Stables JP, Wolf HH. The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. Epilepsia. 49: 1213-20. PMID 18325020 DOI: 10.1111/j.1528-1167.2008.01552.x  0.96
2008 Libbey JE, Kirkman NJ, Smith MC, Tanaka T, Wilcox KS, White HS, Fujinami RS. Seizures following picornavirus infection. Epilepsia. 49: 1066-74. PMID 18325012 DOI: 10.1111/j.1528-1167.2008.01535.x  0.96
2008 Smith MD, Saunders GW, Clausen RP, Frølund B, Krogsgaard-Larsen P, Larsson OM, Schousboe A, Wilcox KS, White HS. Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC). Epilepsy Research. 79: 6-13. PMID 18262393 DOI: 10.1016/j.eplepsyres.2007.12.009  0.96
2008 Statler KD, Swank S, White HS. Strain and age affect electroconvulsive seizure testing in rats. Epilepsy Research. 78: 232-4. PMID 18083004 DOI: 10.1016/j.eplepsyres.2007.11.001  0.96
2008 Klitgaard H, Matagne A, Schachter SC, White HS. Animal and translational models of the epilepsies Animal and Translational Models For Cns Drug Discovery. 2: 311-335. DOI: 10.1016/B978-0-12-373861-5.00020-5  0.96
2007 White HS, Smith MD, Wilcox KS. Mechanisms of action of antiepileptic drugs. International Review of Neurobiology. 81: 85-110. PMID 17433919 DOI: 10.1016/S0074-7742(06)81006-8  0.96
2007 Stöhr T, Kupferberg HJ, Stables JP, Choi D, Harris RH, Kohn H, Walton N, White HS. Lacosamide, a novel anti-convulsant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epilepsy Research. 74: 147-54. PMID 17433624 DOI: 10.1016/j.eplepsyres.2007.03.004  0.96
2007 Smith MD, Adams AC, Saunders GW, White HS, Wilcox KS. Phenytoin- and carbamazepine-resistant spontaneous bursting in rat entorhinal cortex is blocked by retigabine in vitro. Epilepsy Research. 74: 97-106. PMID 17395429 DOI: 10.1016/j.eplepsyres.2007.02.001  0.96
2007 Smith M, Wilcox KS, White HS. Discovery of antiepileptic drugs. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 4: 12-7. PMID 17199014 DOI: 10.1016/j.nurt.2006.11.009  0.96
2007 Lenkowski PW, Batts TW, Smith MD, Ko SH, Jones PJ, Taylor CH, McCusker AK, Davis GC, Hartmann HA, White HS, Brown ML, Patel MK. A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile. Neuropharmacology. 52: 1044-54. PMID 17174360 DOI: 10.1016/j.neuropharm.2006.11.001  0.96
2007 Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK. Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. The Journal of Pharmacology and Experimental Therapeutics. 320: 828-36. PMID 17090703 DOI: 10.1124/jpet.106.111542  0.96
2007 Sobol E, Yagen B, Lamb JG, White HS, Wlodarczyk BJ, Finnell RH, Bialer M. Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide. Epilepsy Research. 73: 75-84. PMID 16997532 DOI: 10.1016/j.eplepsyres.2006.08.004  0.96
2007 Madsen K, White HS, Clausen RP, Frolund B, Larsson OM, Krogsgaard-Larsen P, Schousboe A. Functional and pharmacological aspects of GABA transporters Handbook of Neurochemistry and Molecular Neurobiology: Neural Membranes and Transport. 285-303. DOI: 10.1007/978-0-387-30380-2_14  0.96
2006 Simeone TA, Otto JF, Wilcox KS, White HS. Felbamate is a subunit selective modulator of recombinant gamma-aminobutyric acid type A receptors expressed in Xenopus oocytes. European Journal of Pharmacology. 552: 31-5. PMID 17056029 DOI: 10.1016/j.ejphar.2006.09.002  0.96
2006 Eyal S, Lamb JG, Smith-Yockman M, Yagen B, Fibach E, Altschuler Y, White HS, Bialer M. The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver. British Journal of Pharmacology. 149: 250-60. PMID 16894351 DOI: 10.1038/sj.bjp.0706830  0.96
2006 Poulsen CF, Schousboe I, Sarup A, White HS, Schousboe A. Effect of topiramate and dBcAMP on expression of the glutamate transporters GLAST and GLT-1 in astrocytes cultured separately, or together with neurons. Neurochemistry International. 48: 657-61. PMID 16524645 DOI: 10.1016/j.neuint.2006.01.006  0.96
2006 Clausen RP, Frølund B, Larsson OM, Schousboe A, Krogsgaard-Larsen P, White HS. A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS. Neurochemistry International. 48: 637-42. PMID 16517017 DOI: 10.1016/j.neuint.2005.12.031  0.96
2006 Simeone TA, Wilcox KS, White HS. Subunit selectivity of topiramate modulation of heteromeric GABA(A) receptors. Neuropharmacology. 50: 845-57. PMID 16490221 DOI: 10.1016/j.neuropharm.2005.12.006  0.96
2006 Otto JF, Yang Y, Frankel WN, White HS, Wilcox KS. A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2053-9. PMID 16481438 DOI: 10.1523/JNEUROSCI.1575-05.2006  0.96
2006 Leppik IE, Kelly KM, deToledo-Morrell L, Patrylo PR, DeLorenzo RJ, Mathern GW, White HS. Basic research in epilepsy and aging. Epilepsy Research. 68: S21-37. PMID 16384687 DOI: 10.1016/j.eplepsyres.2005.07.014  0.96
2006 White HS, Smith-Yockman M, Srivastava A, Wilcox KS. Therapeutic Assays for the Identification and Characterization of Antiepileptic and Antiepileptogenic Drugs Models of Seizures and Epilepsy. 539-549. DOI: 10.1016/B978-012088554-1/50046-3  0.96
2005 Klein BD, Fu YH, Ptacek LJ, White HS. Auditory deficits associated with the frings mgr1 (mass1) mutation in mice. Developmental Neuroscience. 27: 321-32. PMID 16137990 DOI: 10.1159/000086712  0.96
2005 White HS, Watson WP, Hansen SL, Slough S, Perregaard J, Sarup A, Bolvig T, Petersen G, Larsson OM, Clausen RP, Frølund B, Falch E, Krogsgaard-Larsen P, Schousboe A. First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. The Journal of Pharmacology and Experimental Therapeutics. 312: 866-74. PMID 15550575 DOI: 10.1124/jpet.104.068825  0.96
2004 Bialer M, Twyman RE, White HS. Correlation analysis between anticonvulsant ED50 values of antiepileptic drugs in mice and rats and their therapeutic doses and plasma levels. Epilepsy & Behavior : E&B. 5: 866-72. PMID 15582834 DOI: 10.1016/j.yebeh.2004.08.021  0.32
2004 Layer RT, Wagstaff JD, White HS. Conantokins: peptide antagonists of NMDA receptors. Current Medicinal Chemistry. 11: 3073-84. PMID 15579001 DOI: 10.2174/0929867043363901  0.96
2004 Klein BD, Fu YH, Ptacek LJ, White HS. c-Fos immunohistochemical mapping of the audiogenic seizure network and tonotopic neuronal hyperexcitability in the inferior colliculus of the Frings mouse. Epilepsy Research. 62: 13-25. PMID 15519128 DOI: 10.1016/j.eplepsyres.2004.06.007  0.96
2004 Schousboe A, Larsson OM, Sarup A, White HS. Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy. European Journal of Pharmacology. 500: 281-7. PMID 15464040 DOI: 10.1016/j.ejphar.2004.07.032  0.36
2004 Schousboe A, Sarup A, Larsson OM, White HS. GABA transporters as drug targets for modulation of GABAergic activity. Biochemical Pharmacology. 68: 1557-63. PMID 15451399 DOI: 10.1016/j.bcp.2004.06.041  0.36
2004 Otto JF, Yang Y, Frankel WN, Wilcox KS, White HS. Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel. Epilepsia. 45: 1009-16. PMID 15329063 DOI: 10.1111/j.0013-9580.2004.65703.x  0.96
2004 Hoover RC, Motta M, Davis J, Saatman KE, Fujimoto ST, Thompson HJ, Stover JF, Dichter MA, Twyman R, White HS, McIntosh TK. Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in rats. Journal of Neurotrauma. 21: 501-12. PMID 15165359 DOI: 10.1089/089771504774129847  0.96
2004 Barton ME, White HS, Wilcox KS. The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on NMDA receptor-mediated EPSCs. Epilepsy Research. 59: 13-24. PMID 15135163 DOI: 10.1016/j.eplepsyres.2003.12.011  0.96
2004 Barton ME, White HS. The effect of CGX-1007 and CI-1041, novel NMDA receptor antagonists, on kindling acquisition and expression. Epilepsy Research. 59: 1-12. PMID 15135162 DOI: 10.1016/j.eplepsyres.2003.12.010  1
2004 Isoherranen N, Levy RH, Yagen B, Woodhead JH, White HS, Bialer M. Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites. Epilepsy Research. 58: 1-12. PMID 15066669 DOI: 10.1016/j.eplepsyres.2003.12.001  0.96
2004 Poulsen CF, Simeone TA, Maar TE, Smith-Swintosky V, White HS, Schousboe A. Modulation by topiramate of AMPA and kainate mediated calcium influx in cultured cerebral cortical, hippocampal and cerebellar neurons. Neurochemical Research. 29: 275-82. PMID 14992287 DOI: 10.1023/B:NERE.0000010456.92887.3b  0.96
2003 Stables JP, Bertram E, Dudek FE, Holmes G, Mathern G, Pitkanen A, White HS. Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia. 44: 1472-8. PMID 14636315 DOI: 10.1111/j.0013-9580.2003.32803.x  0.96
2003 Donevan SD, White HS, Anderson GD, Rho JM. Voltage-dependent block of N-methyl-D-aspartate receptors by the novel anticonvulsant dibenzylamine, a bioactive constituent of L-(+)-beta-hydroxybutyrate. Epilepsia. 44: 1274-9. PMID 14510820 DOI: 10.1046/j.1528-1157.2003.07203.x  0.96
2003 Isoherranen N, White HS, Klein BD, Roeder M, Woodhead JH, Schurig V, Yagen B, Bialer M. Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy. Pharmaceutical Research. 20: 1293-301. PMID 12948028 DOI: 10.1023/A:1025069519218  0.96
2003 Isoherranen N, Yagen B, Spiegelstein O, Finnell RH, Merriweather M, Woodhead JH, Wlodarczyk B, White HS, Bialer M. Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice. British Journal of Pharmacology. 139: 755-64. PMID 12812999 DOI: 10.1038/sj.bjp.0705301  0.36
2003 Yang Y, Beyer BJ, Otto JF, O'Brien TP, Letts VA, White HS, Frankel WN. Spontaneous deletion of epilepsy gene orthologs in a mutant mouse with a low electroconvulsive threshold. Human Molecular Genetics. 12: 975-84. PMID 12700166 DOI: 10.1093/hmg/ddg118  0.96
2003 Isoherranen N, Yagen B, Woodhead JH, Spiegelstein O, Blotnik S, Wilcox KS, Finnell RH, Bennett GD, White HS, Bialer M. Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents. British Journal of Pharmacology. 138: 602-13. PMID 12598414 DOI: 10.1038/sj.bjp.0705076  0.96
2002 Stables JP, Bertram EH, White HS, Coulter DA, Dichter MA, Jacobs MP, Loscher W, Lowenstein DH, Moshe SL, Noebels JL, Davis M. Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland. Epilepsia. 43: 1410-20. PMID 12423393 DOI: 10.1046/j.1528-1157.2002.06702.x  0.96
2002 Jimenez EC, Donevan S, Walker C, Zhou LM, Nielsen J, Cruz LJ, Armstrong H, White HS, Olivera BM. Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency. Epilepsy Research. 51: 73-80. PMID 12350383 DOI: 10.1016/S0920-1211(02)00101-8  0.96
2002 White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, Pickering DS, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A. Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs. The Journal of Pharmacology and Experimental Therapeutics. 302: 636-44. PMID 12130726 DOI: 10.1124/jpet.102.034819  0.36
2002 Rho JM, Anderson GD, Donevan SD, White HS. Acetoacetate, acetone, and dibenzylamine (a contaminant in l-(+)-beta-hydroxybutyrate) exhibit direct anticonvulsant actions in vivo. Epilepsia. 43: 358-61. PMID 11952765 DOI: 10.1046/j.1528-1157.2002.47901.x  0.96
2002 Isoherranen N, White HS, Finnell RH, Yagen B, Woodhead JH, Bennett GD, Wilcox KS, Barton ME, Bialer M. Anticonvulsant profile and teratogenicity of N-methyl-tetramethylcyclopropyl carboxamide: a new antiepileptic drug. Epilepsia. 43: 115-26. PMID 11903457 DOI: 10.1046/j.1528-1157.2002.25801.x  0.96
2001 Barton ME, Klein BD, Wolf HH, White HS. Pharmacological characterization of the 6 Hz psychomotor seizure model of partial epilepsy. Epilepsy Research. 47: 217-27. PMID 11738929 DOI: 10.1016/S0920-1211(01)00302-3  0.96
2001 Skradski SL, Clark AM, Jiang H, White HS, Fu YH, Ptácek LJ. A novel gene causing a mendelian audiogenic mouse epilepsy. Neuron. 31: 537-44. PMID 11545713 DOI: 10.1016/S0896-6273(01)00397-X  0.96
2001 Isoherranen N, Woodhead JH, White HS, Bialer M. Anticonvulsant profile of valrocemide (TV1901): a new antiepileptic drug. Epilepsia. 42: 831-6. PMID 11488880  0.36
2001 Frankel WN, Taylor L, Beyer B, Tempel BL, White HS. Electroconvulsive thresholds of inbred mouse strains. Genomics. 74: 306-12. PMID 11414758 DOI: 10.1006/geno.2001.6564  0.96
2000 Lian H, Steiner SS, Sofia RD, Woodhead JH, Wolf HH, White HS, Shen GS, Rhodes CA, McCabe RT. A self-complementary, self-assembling microsphere system: application for intravenous delivery of the antiepileptic and neuroprotectant compound felbamate. Journal of Pharmaceutical Sciences. 89: 867-75. PMID 10861587 DOI: 10.1002/1520-6017(200007)89:7<867::AID-JPS3>3.0.CO;2-S  0.96
2000 White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH. Topiramate modulates GABA-evoked currents in murine cortical neurons by a nonbenzodiazepine mechanism. Epilepsia. 41: S17-20. PMID 10768294  0.96
2000 Klein BD, White HS, Callahan KS. Cytokine and intracellular signaling regulation of tissue factor expression in astrocytes. Neurochemistry International. 36: 441-9. PMID 10733012 DOI: 10.1016/S0197-0186(99)00147-3  0.96
2000 White HS, McCabe RT, Armstrong H, Donevan SD, Cruz LJ, Abogadie FC, Torres J, Rivier JE, Paarmann I, Hollmann M, Olivera BM. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. The Journal of Pharmacology and Experimental Therapeutics. 292: 425-32. PMID 10604979  0.96
1999 Falch E, Perregaard J, FrŁlund B, SŁkilde B, Buur A, Hansen LM, Frydenvang K, Brehm L, Bolvig T, Larsson OM, Sanchez C, White HS, Schousboe A, Krogsgaard-Larsen P. Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues. Journal of Medicinal Chemistry. 42: 5402-14. PMID 10639282 DOI: 10.1021/jm9904452  0.96
1999 Hanson GR, Jensen M, Johnson M, White HS. Distinct features of seizures induced by cocaine and amphetamine analogs. European Journal of Pharmacology. 377: 167-73. PMID 10456426 DOI: 10.1016/S0014-2999(99)00419-7  0.96
1999 Salvati P, Maj R, Caccia C, Cervini MA, Fornaretto MG, Lamberti E, Pevarello P, Skeen GA, White HS, Wolf HH, Faravelli L, Mazzanti M, Mancinelli E, Varasi M, Fariello RG. Biochemical and electrophysiological studies on the mechanism of action of PNU-151774E, a novel antiepileptic compound. The Journal of Pharmacology and Experimental Therapeutics. 288: 1151-9. PMID 10027853  0.96
1998 Skradski SL, White HS, Ptácek LJ. Genetic mapping of a locus (mass1) causing audiogenic seizures in mice. Genomics. 49: 188-92. PMID 9598305 DOI: 10.1006/geno.1998.5229  0.96
1998 Fariello RG, McArthur RA, Bonsignori A, Cervini MA, Maj R, Marrari P, Pevarello P, Wolf HH, Woodhead JW, White HS, Varasi M, Salvati P, Post C. Preclinical evaluation of PNU-151774E as a novel anticonvulsant. The Journal of Pharmacology and Experimental Therapeutics. 285: 397-403. PMID 9580576  0.96
1998 White HS, Wolf HH, Woodhead JH, Kupferberg HJ. The National Institutes of Health Anticonvulsant Drug Development Program: screening for efficacy. Advances in Neurology. 76: 29-39. PMID 9408461  0.96
1997 White HS, Brown SD, Woodhead JH, Skeen GA, Wolf HH. Topiramate enhances GABA-mediated chloride flux and GABA-evoked chloride currents in murine brain neurons and increases seizure threshold. Epilepsy Research. 28: 167-79. PMID 9332882  0.96
1997 Rostock A, Tober C, Rundfeldt C, Bartsch R, Unverferth K, Engel J, Wolf HH, White HS. AWD 140-190: a new anticonvulsant with a very good margin of safety. Epilepsy Research. 28: 17-28. PMID 9255596  0.96
1997 Bender AS, Woodbury DM, White HS. The rapid L- and D-aspartate uptake in cultured astrocytes. Neurochemical Research. 22: 721-6. PMID 9178956 DOI: 10.1023/A:1027358211472  0.96
1997 Gahring LC, White HS, Skradski SL, Carlson NG, Rogers SW. Interleukin-1alpha in the brain is induced by audiogenic seizure. Neurobiology of Disease. 3: 263-9. PMID 9173924 DOI: 10.1006/nbdi.1996.0123  0.96
1997 Carson JR, Carmosin RJ, Pitis PM, Vaught JL, Almond HR, Stables JP, Wolf HH, Swinyard EA, White HS. Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents. Journal of Medicinal Chemistry. 40: 1578-84. PMID 9171868 DOI: 10.1021/jm9606655  0.96
1997 Kehne JH, Kane JM, Chaney SF, Hurst G, McCloskey TC, Petty MA, Senyah Y, Wolf HH, Zobrist R, White HS. Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties. Epilepsy Research. 27: 41-54. PMID 9169290 DOI: 10.1016/S0920-1211(96)01020-0  0.96
1997 Baron BM, Harrison BL, Kehne JH, Schmidt CJ, van Giersbergen PL, White HS, Siegel BW, Senyah Y, McCloskey TC, Fadayel GM, Taylor VL, Murawsky MK, Nyce P, Salituro FG. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. European Journal of Pharmacology. 323: 181-92. PMID 9128837 DOI: 10.1016/S0014-2999(97)00045-9  0.96
1997 Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor. The Journal of Pharmacology and Experimental Therapeutics. 280: 1284-95. PMID 9067315  0.96
1996 Rostock A, Tober C, Rundfeldt C, Bartsch R, Engel J, Polymeropoulos EE, Kutscher B, Löscher W, Hönack D, White HS, Wolf HH. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Research. 23: 211-23. PMID 8739124  0.96
1995 Palmer GC, Stagnitto ML, Garske GE, Napier JJ, Harris EW, Kaiser FC, Griffith RC, Woodhead JH, White HS, Wolf HH. Anticonvulsant efficacy/safety properties of 2-amino-N-(1,2-diphenylethyl)acetamide hydrochloride. The Journal of Pharmacology and Experimental Therapeutics. 273: 1023-31. PMID 7791072  0.96
1995 White HS, Harmsworth WL, Sofia RD, Wolf HH. Felbamate modulates the strychnine-insensitive glycine receptor. Epilepsy Research. 20: 41-8. PMID 7713059  0.96
1995 White HS, Johnson M, Wolf HH, Kupferberg HJ. The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazol seizure models. Italian Journal of Neurological Sciences. 16: 73-7. PMID 7642355  0.96
1994 Skeen GA, White HS, Twyman RE. The dihydropyridine nitrendipine reduces N-methyl-D-aspartate (NMDA)-evoked currents of rodent cortical neurons through a direct interaction with the NMDA receptor-associated ion channel. The Journal of Pharmacology and Experimental Therapeutics. 271: 30-8. PMID 7965728  0.36
1994 Bender AS, Woodbury DM, White HS. Ionic dependence of adenosine uptake into cultured astrocytes. Brain Research. 661: 1-8. PMID 7834361 DOI: 10.1016/0006-8993(94)91173-8  0.52
1994 Filloux FM, Fitts RC, Skeen GA, White HS. The dihydropyridine nitrendipine inhibits [3H]MK 801 binding to mouse brain sections. European Journal of Pharmacology. 269: 325-30. PMID 7534709  0.36
1993 Skeen GA, Twyman RE, White HS. The dihydropyridine nitrendipine modulates N-methyl-D-aspartate receptor channel function in mammalian neurons. Molecular Pharmacology. 44: 443-50. PMID 8394997  0.36
1993 Swinyard EA, Wolf HH, White HS, Skeen GA, Stark LG, Albertson T, Pong SF, Drust EG. Characterization of the anticonvulsant properties of F-721. Epilepsy Research. 15: 35-45. PMID 8391982  0.96
1993 White HS, Hunt J, Wolf HH, Swinyard EA, Falch E, Krogsgaard-Larsen P, Schousboe A. Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol . European Journal of Pharmacology. 236: 147-9. PMID 8319739 DOI: 10.1016/0014-2999(93)90238-D  0.96
1992 White HS, Wolf HH, Swinyard EA, Skeen GA, Sofia RD. A neuropharmacological evaluation of felbamate as a novel anticonvulsant. Epilepsia. 33: 564-72. PMID 1592038 DOI: 10.1111/j.1528-1157.1992.tb01711.x  0.96
1992 Salituro FG, Harrison BL, Baron BM, Nyce PL, Stewart KT, Kehne JH, White HS, McDonald IA. 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site. Journal of Medicinal Chemistry. 35: 1791-9. PMID 1534125 DOI: 10.1021/jm00088a014  0.96
1992 White HS, Patel S, Meldrum BS. Anticonvulsant profile of MDL 27,266: an orally active, broad-spectrum anticonvulsant agent. Epilepsy Research. 12: 217-26. PMID 1396547 DOI: 10.1016/0920-1211(92)90076-6  0.96
1992 Baron BM, Harrison BL, McDonald IA, Meldrum BS, Palfreyman MG, Salituro FG, Siegel BW, Slone AL, Turner JP, White HS. Potent indole- and quinoline-containing N-methyl-D-aspartate antagonists acting at the strychnine-insensitive glycine binding site. The Journal of Pharmacology and Experimental Therapeutics. 262: 947-56. PMID 1388205  0.96
1992 White HS, Skeen GA, Edwards JA. Pharmacological regulation of astrocytic calcium channels: implications for the treatment of seizure disorders. Progress in Brain Research. 94: 77-87. PMID 1337616 DOI: 10.1016/s0079-6123(08)61741-0  0.36
1992 White HS, Chow SY, Yen-Chow YC, Woodbury DM. Effect of elevated potassium on the ion content of mouse astrocytes and neurons. Canadian Journal of Physiology and Pharmacology. 70: S263-8. PMID 1295676 DOI: 10.1139/y92-271  0.96
1991 Palmer GC, Stagnitto ML, Ordy JM, Griffith RC, Napier JJ, Gentile RJ, Woodhead JH, White HS, Swinyard EA. Preclinical profile of stereoisomers of the anticonvulsant remacemide in mice. Epilepsy Research. 8: 36-48. PMID 2060502  0.36
1991 Chow SY, Yen-Chow YC, White HS, Woodbury DM. pH regulation after acid load in primary cultures of mouse astrocytes. Brain Research. Developmental Brain Research. 60: 69-78. PMID 1914146  0.84
1991 Johnson DN, White HS, Swinyard EA, Albertson TE, Kilpatrick BF. AHR-12245: a potential anti-absence drug. Epilepsy Research. 8: 64-70. PMID 1905625 DOI: 10.1016/0920-1211(91)90037-G  0.96
1991 Swinyard EA, White HS, Wolf HH, Bondinell WE. Anticonvulsant profiles of the potent and orally active GABA uptake inhibitors SK&F 89976-A and SK&F 100330-A and four prototype antiepileptic drugs in mice and rats. Epilepsia. 32: 569-77. PMID 1831122  0.96
1991 Chow SY, Yen-Chow YC, White HS, Hertz L, Woodbury DM. Effects of potassium on the anion and cation contents of primary cultures of mouse astrocytes and neurons. Neurochemical Research. 16: 1275-83. PMID 1784325 DOI: 10.1007/BF00966658  0.96
1991 Code WE, White HS, Hertz L. The effect of midazolam on calcium signaling in astrocytes. Annals of the New York Academy of Sciences. 625: 430-2. PMID 1647735  0.6
1990 Code WE, Hertz L, White HS. Midazolam potently affects free calcium concentration in astrocytes. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 37: S27. PMID 2163291  0.6
1989 Hertz L, Bender AS, Woodbury DM, White HS. Potassium-stimulated calcium uptake in astrocytes and its potent inhibition by nimodipine. Journal of Neuroscience Research. 22: 209-15. PMID 2709443 DOI: 10.1002/jnr.490220215  0.84
1989 Chow SY, White HS, Yen-Chow YC, Woodbury DM. Uptakes of iodide and chloride by primary cultures of mouse astrocytes and neurons. Neurochemical Research. 14: 963-9. PMID 2608161  0.84
1989 Bender AS, Woodbury DM, White HS. Beta-DL-methylene-aspartate, an inhibitor of aspartate aminotransferase, potently inhibits L-glutamate uptake into astrocytes. Neurochemical Research. 14: 641-6. PMID 2571095 DOI: 10.1007/BF00964873  0.64
1988 White HS, Bender AS, Swinyard EA. Effect of the selective N-methyl-D-aspartate receptor agonist 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid on [3H]flunitrazepam binding. European Journal of Pharmacology. 147: 149-51. PMID 2836217 DOI: 10.1016/0014-2999(88)90646-2  0.32
1987 Chow SY, Yen-Chow YC, White HS, Woodbury DM. Effects of 4,4'-di-isothiocyano-2,2'-stilbene disulphonate on iodide uptake by primary cultures of turtle thyroid follicular cells. The Journal of Endocrinology. 113: 403-12. PMID 2442278  0.84
1986 White HS, Woodbury DM, Chen CF, Kemp JW, Chow SY, Yen-Chow YC. Role of glial cation and anion transport mechanisms in etiology and arrest of seizures. Advances in Neurology. 44: 695-712. PMID 3706023  0.84
1986 Engstrom FL, White HS, Kemp JW, Woodbury DM. Acute and chronic acetazolamide administration in DBA and C57 mice: effects of age. Epilepsia. 27: 19-26. PMID 3081335  0.84
1986 Chow SY, Yen-Chow YC, White HS, Woodbury DM. Effects of sodium on iodide transport in primary cultures of turtle thyroid cells. The American Journal of Physiology. 250: E464-9. PMID 3008570  0.84
1985 White HS, Yen-Chow YC, Chow SY, Kemp JW, Woodbury DM. Effects of phenytoin on primary glial cell cultures. Epilepsia. 26: 58-68. PMID 2982597  0.84
1985 White HS, Chen CF, Kemp JW, Woodbury DM. Effects of acute and chronic phenytoin on the electrolyte content and the activities of Na+, K+-, Ca2+, Mg2+-, and HCO3- -ATPases and carbonic anhydrase of neonatal and adult rat cerebral cortex. Epilepsia. 26: 43-57. PMID 2982596  0.84
1984 Woodbury DM, Engstrom FL, White HS, Chen CF, Kemp JW, Chow SY. Ionic and acid-base regulation of neurons and glia during seizures. Annals of Neurology. 16: S135-44. PMID 6150682  0.84
1980 White HS, Isom GE. Localization of the central cardiovascular action of dibutyryl cyclic AMP. Proceedings of the Western Pharmacology Society. 23: 33-5. PMID 6250153  0.96
1979 White HS, Driver PS, Isom GE. Studies on the central pressor activity of dibutyryl cyclic AMP. European Journal of Pharmacology. 57: 107-13. PMID 226371 DOI: 10.1016/0014-2999(79)90356-X  0.96
1978 White HS, Isom GE. Central effects of N6, O2'-dibutyryl adenosine 3',5'-cyclic monophosphate on blood pressure. Proceedings of the Western Pharmacology Society. 21: 253-6. PMID 211527  0.96
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