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Guy C. Le Breton - Publications

Affiliations: 
University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Cell Biology, Pharmacology, Neuroscience Biology
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Srinivasan S, Schiemer J, Zhang X, Chishti AH, Le Breton GC. Gα13 Switch Region 2 Binds to the Talin Head Domain and Activates αIIbβ3 Integrin in Human Platelets. The Journal of Biological Chemistry. PMID 26292217 DOI: 10.1074/jbc.M115.650978  0.34
2011 Gussin HA, Khasawneh FT, Xie A, Feng F, Memic A, Qian H, Le Breton GC, Pepperberg DR. Subunit-specific polyclonal antibody targeting human ρ1 GABA(C) receptor. Experimental Eye Research. 93: 59-64. PMID 21536029 DOI: 10.1016/J.Exer.2011.04.009  0.62
2009 Srinivasan S, Mir F, Huang JS, Khasawneh FT, Lam SC, Le Breton GC. The P2Y12 antagonists, 2-methylthioadenosine 5'-monophosphate triethylammonium salt and cangrelor (ARC69931MX), can inhibit human platelet aggregation through a Gi-independent increase in cAMP levels. The Journal of Biological Chemistry. 284: 16108-17. PMID 19346255 DOI: 10.1074/Jbc.M809780200  0.742
2008 Mir F, Le Breton GC. A novel nuclear signaling pathway for thromboxane A2 receptors in oligodendrocytes: evidence for signaling compartmentalization during differentiation. Molecular and Cellular Biology. 28: 6329-41. PMID 18710937 DOI: 10.1128/MCB.00482-08  0.318
2008 Khasawneh FT, Huang JS, Mir F, Srinivasan S, Tiruppathi C, Le Breton GC. Characterization of isoprostane signaling: evidence for a unique coordination profile of 8-iso-PGF(2alpha) with the thromboxane A(2) receptor, and activation of a separate cAMP-dependent inhibitory pathway in human platelets. Biochemical Pharmacology. 75: 2301-15. PMID 18455148 DOI: 10.1016/J.Bcp.2008.03.014  0.673
2007 Huang JS, Dong L, Kozasa T, Le Breton GC. Signaling through G(alpha)13 switch region I is essential for protease-activated receptor 1-mediated human platelet shape change, aggregation, and secretion. The Journal of Biological Chemistry. 282: 10210-22. PMID 17298951 DOI: 10.1074/Jbc.M605678200  0.37
2006 Ramamurthy S, Mir F, Gould RM, Le Breton GC. Characterization of thromboxane A2 receptor signaling in developing rat oligodendrocytes: nuclear receptor localization and stimulation of myelin basic protein expression. Journal of Neuroscience Research. 84: 1402-14. PMID 16998891 DOI: 10.1002/Jnr.21061  0.772
2006 Khasawneh FT, Huang JS, Turek JW, Le Breton GC. Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. The Journal of Biological Chemistry. 281: 26951-65. PMID 16837469 DOI: 10.1182/Blood.V106.11.3571.3571  0.729
2006 Huang JS, Dong L, Le Breton GC. Mass-dependent signaling between G protein coupled receptors. Cellular Signalling. 18: 564-76. PMID 16125366 DOI: 10.1016/j.cellsig.2005.06.011  0.461
2005 Lin X, Ramamurthy SK, Le Breton GC. Thromboxane A receptor-mediated cell proliferation, survival and gene expression in oligodendrocytes. Journal of Neurochemistry. 93: 257-68. PMID 15816849 DOI: 10.1111/j.1471-4159.2004.02969.x  0.777
2004 Huang JS, Ramamurthy SK, Lin X, Le Breton GC. Cell signalling through thromboxane A2 receptors. Cellular Signalling. 16: 521-33. PMID 14751539 DOI: 10.1016/j.cellsig.2003.10.008  0.799
2003 Manganello JM, Huang JS, Kozasa T, Voyno-Yasenetskaya TA, Le Breton GC. Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation. The Journal of Biological Chemistry. 278: 124-30. PMID 12399457 DOI: 10.1074/Jbc.M209219200  0.749
2002 Turek JW, Halmos T, Sullivan NL, Antonakis K, Le Breton GC. Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. The Journal of Biological Chemistry. 277: 16791-7. PMID 11877412 DOI: 10.1074/Jbc.M105872200  0.683
2001 Muja N, Blackman SC, Le Breton GC, DeVries GH. Identification and functional characterization of thromboxane A2 receptors in Schwann cells. Journal of Neurochemistry. 78: 446-56. PMID 11483647 DOI: 10.1046/J.1471-4159.2001.00378.X  0.778
2000 Djellas Y, Antonakis K, Le Breton GC. Shifts in the affinity distribution of one class of seven-transmembrane receptors by activation of a separate class of seven-transmembrane receptors Biochemical Pharmacology. 59: 1521-1529. PMID 10799648 DOI: 10.1016/S0006-2952(00)00296-3  0.49
1999 Halmos T, Turek JW, Le Breton GC, Antonakis K. Synthesis and biological characterization of sqbazide, a novel biotinylated photoaffinity probe for the study of the human platelet thromboxane A2 receptor. Bioorganic & Medicinal Chemistry Letters. 9: 2963-8. PMID 10571156 DOI: 10.1016/S0960-894X(99)00511-9  0.672
1999 Manganello JM, Djellas Y, Borg C, Antonakis K, Le Breton GC. Cyclic AMP-dependent phosphorylation of thromboxane A(2) receptor-associated Galpha(13). The Journal of Biological Chemistry. 274: 28003-10. PMID 10488151 DOI: 10.1074/jbc.274.39.28003  0.774
1999 Blackman SC, Borg C, Yeomans DC, Le Breton GC. Assessment of cellular localization of the thromboxane A2 receptor by immunocytochemistry. Methods in Molecular Biology (Clifton, N.J.). 120: 145-71. PMID 10343316 DOI: 10.1385/1-59259-263-5:145  0.736
1999 Djellas Y, Manganello JM, Antonakis K, Le Breton GC. Identification of Galpha13 as one of the G-proteins that couple to human platelet thromboxane A2 receptors. The Journal of Biological Chemistry. 274: 14325-30. PMID 10318854 DOI: 10.1074/Jbc.274.20.14325  0.773
1998 Djellas Y, Antonakis K, Le Breton GC. A molecular mechanism for signaling between seven-transmembrane receptors: Evidence for a redistribution of G proteins Proceedings of the National Academy of Sciences of the United States of America. 95: 10944-10948. PMID 9724809 DOI: 10.1073/pnas.95.18.10944  0.517
1998 Blackman SC, Dawson G, Antonakis K, Le Breton GC. The identification and characterization of oligodendrocyte thromboxane A2 receptors. The Journal of Biological Chemistry. 273: 475-83. PMID 9417106 DOI: 10.1074/Jbc.273.1.475  0.777
1996 Nakamura F, Minshall RD, Le Breton GC, Rabito SF. Thromboxane A2 mediates the stimulation of inositol 1,4,5- trisphosphate production and intracellular calcium mobilization by bradykinin in neonatal rat ventricular cardiomyocytes Hypertension. 28: 444-449. PMID 8794831  0.335
1996 Komiotis D, Wencel-Drake JD, Dieter JP, Lim CT, Le Breton GC. Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe Biochemical Pharmacology. 52: 763-770. PMID 8765474 DOI: 10.1016/0006-2952(96)00359-0  0.34
1996 Bresnahan BA, Le Breton GC, Lianos EA. Localization of authentic thromboxane A2/prostaglandin H2 receptor in the rat kidney. Kidney International. 49: 1207-13. PMID 8731083 DOI: 10.1038/ki.1996.174  0.406
1994 Borg C, Lim CT, Yeomans DC, Dieter JP, Komiotis D, Anderson EG, Le Breton GC. Purification of rat brain, rabbit aorta, and human platelet thromboxane A2/prostaglandin H2 receptors by immunoaffinity chromatography employing anti-peptide and anti-receptor antibodies. The Journal of Biological Chemistry. 269: 6109-16. PMID 8119956  0.421
1993 Knezevic I, Borg C, Le Breton GC. Identification of Gq as one of the G-proteins which copurify with human platelet thromboxane A2/prostaglandin H2 receptors Journal of Biological Chemistry. 268: 26011-26017. PMID 8245033  0.502
1993 Borg C, Lam SCT, Dieter JP, Lim CT, Komiotis D, Venton DL, le Breton GC. Anti-peptide antibodies against the human blood platelet thromboxane A2/prostaglandin H2 receptor. Production, purification and characterization Biochemical Pharmacology. 45: 2071-2078. PMID 7685602 DOI: 10.1016/0006-2952(93)90018-R  0.362
1992 Sun-Ok K, Chang T. L, Lam SCT, Hall SE, Komiotis D, Venton DL, Le Breton GC. Purification of the human blood platelet thromboxane A2/prostaglandin H2 receptor protein Biochemical Pharmacology. 43: 313-322. PMID 1739420 DOI: 10.1016/0006-2952(92)90294-S  0.444
1990 Le Breton GC, Lim CT, Vaidya CM, Venton DL. Thromboxane A2/prostaglandin H2 receptor antagonists Methods in Enzymology. 187: 406-414. PMID 2146463 DOI: 10.1016/0076-6879(90)87047-7  0.445
1989 Swann PG, Venton DL, Le Breton GC. Eicosapentaenoic acid and docosahexaenoic acid are antagonists at the thromboxane A2/prostaglandin H2 receptor in human platelets Febs Letters. 243: 244-246. PMID 2537230 DOI: 10.1016/0014-5793(89)80137-1  0.347
1987 Arora SK, Kattelman EJ, Lim CT, Le Breton GC, Venton DL. Preparation and biological evaluation of a potential photoaffinity label for the prostaglandin H2/thromboxane A2 receptor Journal of Medicinal Chemistry. 30: 918-924. PMID 2952799 DOI: 10.1021/Jm00388A029  0.357
1987 Kattelman EJ, Arora SK, Lim CT, Venton DL, Le Breton GC. A photoaffinity label for the thromboxane A2/prostaglandin H2 receptor in human blood platelets Febs Letters. 213: 179-183. PMID 2951273 DOI: 10.1016/0014-5793(87)81487-4  0.336
1984 Le Breton GC, Hung SC, Ghali NI, Venton DL. 2-(6-carboxyhexyl)cyclopentanone hexylhydrazone: A potent inhibitor of the blood platelet cyclo-oxygenase Prostaglandins. 27: 543-551. PMID 6427851 DOI: 10.1016/0090-6980(84)90090-X  0.327
1984 Parise LV, Venton DL, Le Breton GC. Arachidonic acid-induced platelet aggregation is mediated by a thromboxane A2/prostaglandin H2 receptor interaction Journal of Pharmacology and Experimental Therapeutics. 228: 240-244. PMID 6319669  0.338
1980 Le Breton GC, Venton DL. Thromboxane A2 receptor antagonism selectively reverses platelet aggregation Advances in Prostaglandin and Thromboxane Research. 6: 497-503. PMID 7386283  0.335
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