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Susan T. Sharfstein - Publications

Affiliations: 
1996-2001 Bioengineering The University of Toledo 
 2001- Chemical Engineering Rensselaer Polytechnic Institute, Troy, NY, United States 
Area:
Cell Biology, Biomedical Engineering
Website:
https://www.rpi.edu/dept/chem-eng/WWW/faculty/
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Masson HO, Samoudi M, Robinson CM, Kuo CC, Weiss L, Shams Ud Doha K, Campos A, Tejwani V, Dahodwala H, Menard P, Voldborg BG, Robasky B, Sharfstein ST, Lewis NE. Inferring secretory and metabolic pathway activity from omic data with secCellFie. Metabolic Engineering. PMID 38145748 DOI: 10.1016/j.ymben.2023.12.006  0.762
2023 Masson HO, Samoudi M, Robinson CM, Kuo CC, Weiss L, Ud Doha KS, Campos A, Tejwani V, Dahodwala H, Menard P, Voldborg BG, Sharfstein ST, Lewis NE. Inferring secretory and metabolic pathway activity from omic data with secCellFie. Biorxiv : the Preprint Server For Biology. PMID 37205389 DOI: 10.1101/2023.05.04.539316  0.763
2022 Dahodwala H, Amenyah SD, Nicoletti S, Henry MN, Lees-Murdock DJ, Sharfstein ST. Evaluation of site-specific methylation of the CMV promoter and its role in CHO cell productivity of a recombinant monoclonal antibody. Antibody Therapeutics. 5: 121-129. PMID 35719211 DOI: 10.1093/abt/tbac010  0.729
2022 Thacker BE, Thorne KJ, Cartwright C, Park J, Glass K, Chea A, Kellman BP, Lewis NE, Wang Z, Di Nardo A, Sharfstein ST, Jeske W, Walenga J, Hogwood J, Gray E, et al. Multiplex genome editing of mammalian cells for producing recombinant heparin. Metabolic Engineering. PMID 35038554 DOI: 10.1016/j.ymben.2022.01.002  0.314
2021 Tejwani V, Chaudhari M, Rai T, Sharfstein ST. High-throughput and automation advances for accelerating single-cell cloning, monoclonality and early phase clone screening steps in mammalian cell line development for biologics production. Biotechnology Progress. e3208. PMID 34478248 DOI: 10.1002/btpr.3208  0.344
2020 Muralidharan-Chari V, Wurz Z, Doyle F, Henry M, Diendorfer A, Tenenbaum SA, Borth N, Eveleth E, Sharfstein ST. PTSelect™: A post-transcriptional technology that enables rapid establishment of stable CHO cell lines and surveillance of clonal variation. Journal of Biotechnology. PMID 33115662 DOI: 10.1016/j.jbiotec.2020.09.025  0.372
2020 Amini N, Paluh JL, Xie Y, Saxena V, Sharfstein ST. Insulin production from hiPSC-derived pancreatic cells in a novel wicking matrix bioreactor. Biotechnology and Bioengineering. PMID 32314809 DOI: 10.1002/Bit.27359  0.404
2020 Sharfstein S. Review for "A Class of Low‐Cost Alternatives to Kifunensine for Increasing High Mannose N‐linked glycosylation for Monoclonal Antibody Production in CHO Cells" Biotechnology Progress. DOI: 10.1002/Btpr.3076/V2/Review1  0.374
2019 Dahodwala H, Kaushik P, Tejwani V, Kuo CC, Menard P, Henry M, Voldborg BG, Lewis NE, Meleady P, Sharfstein ST. Increased mAb production in amplified CHO cell lines is associated with increased interaction of CREB1 with transgene promoter. Current Research in Biotechnology. 1: 49-57. PMID 32577618 DOI: 10.1016/j.crbiot.2019.09.001  0.775
2019 Li S, Cha SW, Hefner K, Hizal DB, Bowen MA, Chaerkady R, Cole RN, Tejwani V, Kaushik P, Henry M, Meleady P, Sharfstein ST, Betenbaugh MJ, Bafna V, Lewis NE. Proteogenomic annotation of the Chinese hamster reveals extensive novel translation events and endogenous retroviral elements. Journal of Proteome Research. PMID 31020842 DOI: 10.1021/Acs.Jproteome.8B00935  0.37
2019 Sharfstein S. Review for "Effective temperature shift strategy development and scale confirmation for simultaneous optimization of protein productivity and quality in Chinese hamster ovary cells" Biotechnology Progress. DOI: 10.1002/Btpr.2959/V1/Review2  0.354
2018 Thacker BE, Sharfstein ST. Metabolic engineering of mammalian cells to produce heparan sulfates. Emerging Topics in Life Sciences. 2: 443-452. PMID 33525792 DOI: 10.1042/ETLS20180007  0.309
2018 Tejwani V, Andersen MR, Nam JH, Sharfstein ST. Glycoengineering in CHO cells: Advances in systems biology. Biotechnology Journal. PMID 29316325 DOI: 10.1002/Biot.201700234  0.453
2018 Sharfstein ST. Non-protein biologic therapeutics. Current Opinion in Biotechnology. 53: 65-75. PMID 29289799 DOI: 10.1016/J.Copbio.2017.12.014  0.332
2017 Dahodwala H, Sharfstein ST. Biosimilars: Imitation Games. Acs Medicinal Chemistry Letters. 8: 690-693. PMID 28740599 DOI: 10.1021/Acsmedchemlett.7B00199  0.728
2017 Dahodwala H, Sharfstein ST. The 'Omics Revolution in CHO Biology: Roadmap to Improved CHO Productivity. Methods in Molecular Biology (Clifton, N.J.). 1603: 153-168. PMID 28493129 DOI: 10.1007/978-1-4939-6972-2_10  0.765
2016 Torrejon KY, Papke EL, Halman JR, Bergkvist M, Danias J, Sharfstein ST, Xie Y. TGFβ2-induced outflow alterations in a bioengineered trabecular meshwork are offset by a rho-associated kinase inhibitor. Scientific Reports. 6: 38319. PMID 27924833 DOI: 10.1038/Srep38319  0.302
2016 Oduah EI, Linhardt RJ, Sharfstein ST. Heparin: Past, Present, and Future. Pharmaceuticals (Basel, Switzerland). 9. PMID 27384570 DOI: 10.3390/Ph9030038  0.374
2015 Torrejon KY, Papke EL, Halman JR, Stolwijk J, Dautriche CN, Bergkvist M, Danias J, Sharfstein ST, Xie Y. Bioengineered glaucomatous 3D human trabecular meshwork as an in vitro disease model. Biotechnology and Bioengineering. PMID 26615056 DOI: 10.1002/Bit.25899  0.314
2015 Dautriche CN, Tian Y, Xie Y, Sharfstein ST. A Closer Look at Schlemm's Canal Cell Physiology: Implications for Biomimetics. Journal of Functional Biomaterials. 6: 963-85. PMID 26402712 DOI: 10.3390/Jfb6030963  0.341
2015 Dautriche CN, Szymanski D, Kerr M, Torrejon KY, Bergkvist M, Xie Y, Danias J, Stamer WD, Sharfstein ST. A biomimetic Schlemm's canal inner wall: A model to study outflow physiology, glaucoma pathology and high-throughput drug screening. Biomaterials. 65: 86-92. PMID 26142779 DOI: 10.1016/J.Biomaterials.2015.06.034  0.39
2015 Baik JY, Dahodwala H, Oduah E, Talman L, Gemmill TR, Gasimli L, Datta P, Yang B, Li G, Zhang F, Li L, Linhardt RJ, Campbell AM, Gorfien SF, Sharfstein ST. Optimization of bioprocess conditions improves production of a CHO cell-derived, bioengineered heparin. Biotechnology Journal. 10: 1067-81. PMID 26037948 DOI: 10.1002/Biot.201400665  0.772
2015 Datta P, Yang B, Linhardt RJ, Sharfstein ST. Modulation of heparan sulfate biosynthesis by sodium butyrate in recombinant CHO cells. Cytotechnology. 67: 223-35. PMID 24468831 DOI: 10.1007/S10616-013-9677-9  0.405
2014 Dautriche CN, Xie Y, Sharfstein ST. Walking through trabecular meshwork biology: Toward engineering design of outflow physiology. Biotechnology Advances. 32: 971-83. PMID 24806891 DOI: 10.1016/J.Biotechadv.2014.04.012  0.32
2014 Gasimli L, Glass CA, Datta P, Yang B, Li G, Gemmill TR, Baik JY, Sharfstein ST, Esko JD, Linhardt RJ. Bioengineering murine mastocytoma cells to produce anticoagulant heparin. Glycobiology. 24: 272-80. PMID 24326668 DOI: 10.1093/Glycob/Cwt108  0.387
2014 Datta P, Meli L, Li L, Migliore N, Schaefer E, Sharfstein ST, Dordick JS, Linhardt RJ. Microarray platform affords improved product analysis in mammalian cell growth studies. Biotechnology Journal. 9: 386-95. PMID 24227746 DOI: 10.1002/Biot.201300288  0.461
2014 Dahodwala H, Sharfstein ST. Role of epigenetics in expression of recombinant proteins from mammalian cells Pharmaceutical Bioprocessing. 2: 403-419. DOI: 10.4155/Pbp.14.47  0.762
2014 Mason M, Sweeney B, Cain K, Stephens P, Sharfstein S. Reduced Culture Temperature Differentially Affects Expression and Biophysical Properties of Monoclonal Antibody Variants Antibodies. 3: 253-271. DOI: 10.3390/Antib3030253  0.384
2013 Datta P, Li G, Yang B, Zhao X, Baik JY, Gemmill TR, Sharfstein ST, Linhardt RJ. Bioengineered Chinese hamster ovary cells with Golgi-targeted 3-O-sulfotransferase-1 biosynthesize heparan sulfate with an antithrombin-binding site. The Journal of Biological Chemistry. 288: 37308-18. PMID 24247246 DOI: 10.1074/Jbc.M113.519033  0.347
2013 Torrejon KY, Pu D, Bergkvist M, Danias J, Sharfstein ST, Xie Y. Recreating a human trabecular meshwork outflow system on microfabricated porous structures. Biotechnology and Bioengineering. 110: 3205-18. PMID 23775275 DOI: 10.1002/Bit.24977  0.362
2013 Datta P, Linhardt RJ, Sharfstein ST. An 'omics approach towards CHO cell engineering. Biotechnology and Bioengineering. 110: 1255-71. PMID 23322664 DOI: 10.1002/Bit.24841  0.488
2012 Baik JY, Wang CL, Yang B, Linhardt RJ, Sharfstein S. Toward a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cells. Bioengineered. 3: 227-31. PMID 22714556 DOI: 10.4161/Bioe.20902  0.432
2012 Zhang H, Lee MY, Hogg MG, Dordick JS, Sharfstein ST. High-throughput transfection of interfering RNA into a 3D cell-culture chip. Small (Weinheim An Der Bergstrasse, Germany). 8: 2091-8. PMID 22511323 DOI: 10.1002/Smll.201102205  0.58
2012 Mason M, Sweeney B, Cain K, Stephens P, Sharfstein ST. Identifying bottlenecks in transient and stable production of recombinant monoclonal-antibody sequence variants in Chinese hamster ovary cells. Biotechnology Progress. 28: 846-55. PMID 22467228 DOI: 10.1002/Btpr.1542  0.369
2012 Baik JY, Gasimli L, Yang B, Datta P, Zhang F, Glass CA, Esko JD, Linhardt RJ, Sharfstein ST. Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin. Metabolic Engineering. 14: 81-90. PMID 22326251 DOI: 10.1016/J.Ymben.2012.01.008  0.463
2012 Dahodwala H, Nowey M, Mitina T, Sharfstein ST. Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: a study of Chinese hamster ovary cells producing a recombinant monoclonal antibody. Cytotechnology. 64: 27-41. PMID 21822681 DOI: 10.1007/S10616-011-9388-Z  0.758
2011 Kiehl TR, Shen D, Khattak SF, Jian Li Z, Sharfstein ST. Observations of cell size dynamics under osmotic stress. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 79: 560-9. PMID 21656664 DOI: 10.1002/Cyto.A.21076  0.428
2011 Baughman AC, Sharfstein ST, Martin LL. A flexible state-space approach for the modeling of metabolic networks II: advanced interrogation of hybridoma metabolism. Metabolic Engineering. 13: 138-49. PMID 21163360 DOI: 10.1016/J.Ymben.2010.12.003  0.317
2010 Zhang H, Lee MY, Hogg MG, Dordick JS, Sharfstein ST. Gene delivery in three-dimensional cell cultures by superparamagnetic nanoparticles. Acs Nano. 4: 4733-43. PMID 20731451 DOI: 10.1021/Nn9018812  0.59
2010 Shen D, Kiehl TR, Khattak SF, Li ZJ, He A, Kayne PS, Patel V, Neuhaus IM, Sharfstein ST. Transcriptomic responses to sodium chloride-induced osmotic stress: a study of industrial fed-batch CHO cell cultures. Biotechnology Progress. 26: 1104-15. PMID 20306541 DOI: 10.1002/Btpr.398  0.489
2010 Baughman AC, Huang X, Sharfstein ST, Martin LL. On the dynamic modeling of mammalian cell metabolism and mAb production Computers and Chemical Engineering. 34: 210-222. DOI: 10.1016/J.Compchemeng.2009.06.019  0.304
2009 Nam JH, Ermonval M, Sharfstein ST. The effects of microcarrier culture on recombinant CHO cells under biphasic hypothermic culture conditions. Cytotechnology. 59: 81-91. PMID 19412658 DOI: 10.1007/S10616-009-9196-X  0.393
2009 Jiang Z, Sharfstein ST. Characterization of gene localization and accessibility in DHFR-amplified CHO cells. Biotechnology Progress. 25: 296-300. PMID 19224609 DOI: 10.1002/Btpr.82  0.375
2008 Nam JH, Zhang F, Ermonval M, Linhardt RJ, Sharfstein ST. The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells Biotechnology and Bioengineering. 100: 1178-1192. PMID 18553404 DOI: 10.1002/Bit.21853  0.37
2008 Sharfstein ST. Advances in cell culture process development: Tools and techniques for improving cell line development and process optimization Biotechnology Progress. 24: 727-734. PMID 18426245 DOI: 10.1021/Bp070471Q  0.445
2008 Jiang Z, Sharfstein ST. Sodium butyrate stimulates monoclonal antibody over-expression in CHO cells by improving gene accessibility. Biotechnology and Bioengineering. 100: 189-94. PMID 18023047 DOI: 10.1002/Bit.21726  0.421
2007 Jong HN, Ermonval M, Sharfstein ST. Cell attachment to microcarriers affects growth, metabolic activity, and culture productivity in bioreactor culture Biotechnology Progress. 23: 652-660. PMID 17500530 DOI: 10.1021/Bp070007L  0.406
2007 Venkiteshwaran A, Heider P, Matosevic S, Bogsnes A, Staby A, Sharfstein S, Belfort G. Optimized removal of soluble host cell proteins for the recovery of met-human growth hormone inclusion bodies from Escherichia coli cell lysate using crossflow microfiltration Biotechnology Progress. 23: 667-672. PMID 17480055 DOI: 10.1021/Bp0700253  0.337
2006 Jiang Z, Huang Y, Sharfstein ST. Regulation of recombinant monoclonal antibody production in Chinese hamster ovary cells: A comparative study of gene copy number, mRNA level, and protein expression Biotechnology Progress. 22: 313-318. PMID 16454525 DOI: 10.1021/Bp0501524  0.426
2006 Shen D, Sharfstein ST. Genome-wide analysis of the transcriptional response of murine hybridomas to osmotic shock Biotechnology and Bioengineering. 93: 132-145. PMID 16196057 DOI: 10.1002/Bit.20691  0.348
2005 McNeeley KM, Sun Z, Sharfstein ST. Techniques for dual staining of DNA and intracellular immunoglobulins in murine hybridoma cells: applications to cell-cycle analysis of hyperosmotic cultures. Cytotechnology. 48: 15-26. PMID 19003029 DOI: 10.1007/S10616-005-2926-9  0.373
2004 Sun Z, Zhou R, Liang S, McNeeley KM, Sharfstein ST. Hyperosmotic stress in murine hybridoma cells: effects on antibody transcription, translation, posttranslational processing, and the cell cycle. Biotechnology Progress. 20: 576-89. PMID 15059005 DOI: 10.1021/Bp0342203  0.382
1998 Mancuso A, Sharfstein ST, Fernandez EJ, Clark DS, Blanch HW. Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma: an in vivo 13C nuclear magnetic resonance study. Biotechnology and Bioengineering. 57: 172-86. PMID 10099192 DOI: 10.1002/(Sici)1097-0290(19980120)57:2<172::Aid-Bit6>3.0.Co;2-K  0.676
1994 Mancuso A, Sharfstein ST, Tucker SN, Clark DS, Blanch HW. Examination of primary metabolic pathways in a murine hybridoma with carbon-13 nuclear magnetic resonance spectroscopy. Biotechnology and Bioengineering. 44: 563-85. PMID 18618793 DOI: 10.1002/Bit.260440504  0.523
1994 Sharfstein ST, Tucker SN, Mancuso A, Blanch HW, Clark DS. Quantitative in vivo nuclear magnetic resonance studies of hybridoma metabolism. Biotechnology and Bioengineering. 43: 1059-74. PMID 18615517 DOI: 10.1002/Bit.260431109  0.545
1994 Sharfstein ST, Keasling JD. Polyphosphate metabolism in escherichia coli Annals of the New York Academy of Sciences. 745: 77-91. PMID 7832534 DOI: 10.1111/J.1749-6632.1994.Tb44365.X  0.307
1992 Sharfstein ST, Gaillard B, Blanch HW, Clark DS. Functional differentiation and primary metabolism of mouse mammary epithelial cells in extended-batch and hollow-fiber culture. Biotechnology and Bioengineering. 40: 672-80. PMID 18601166 DOI: 10.1002/Bit.260400605  0.563
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