Chris B. Schaffer, Ph.D. - Publications

Affiliations: 
Biomedical Engineering Cornell University, Ithaca, NY, United States 
Area:
Cerebral blood flow, neurodegeneration, optical imaging, nonlinear microscopy
Website:
http://www.bme.cornell.edu/schafferlab

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Ali M, Falkenhain K, Njiru BN, Murtaza-Ali M, Ruiz-Uribe NE, Haft-Javaherian M, Catchers S, Nishimura N, Schaffer CB, Bracko O. VEGF signalling causes stalls in brain capillaries and reduces cerebral blood flow in Alzheimer's mice. Brain : a Journal of Neurology. PMID 35048960 DOI: 10.1093/brain/awab387  0.814
2021 Bracko O, Cruz Hernández JC, Park L, Nishimura N, Schaffer CB. Causes and consequences of baseline cerebral blood flow reductions in Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X20982383. PMID 33444096 DOI: 10.1177/0271678X20982383  0.606
2020 Bares AJ, Mejooli MA, Pender MA, Leddon SA, Tilley S, Lin K, Dong J, Kim M, Fowell DJ, Nishimura N, Schaffer CB. Hyperspectral multiphoton microscopy for visualization of multiple, spectrally overlapped fluorescent labels. Optica. 7: 1587-1601. PMID 33928182 DOI: 10.1364/optica.389982  0.57
2020 Haft-Javaherian M, Villiger M, Schaffer CB, Nishimura N, Golland P, Bouma BE. A topological encoding convolutional neural network for segmentation of 3D multiphoton images of brain vasculature using persistent homology. Conference On Computer Vision and Pattern Recognition Workshops. Ieee Computer Society Conference On Computer Vision and Pattern Recognition. Workshops. 2020: 4262-4271. PMID 33889437 DOI: 10.1109/cvprw50498.2020.00503  0.801
2020 Falkenhain K, Ruiz-Uribe NE, Haft-Javaherian M, Ali M, Michelucci PE, Schaffer CB, Bracko O. A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer's disease. Plos One. 15: e0235691. PMID 32857763 DOI: 10.1371/Journal.Pone.0235691  0.807
2020 Bracko O, Vinarcsik LK, Cruz Hernández JC, Ruiz-Uribe NE, Haft-Javaherian M, Falkenhain K, Ramanauskaite EM, Ali M, Mohapatra A, Swallow MA, Njiru BN, Muse V, Michelucci PE, Nishimura N, Schaffer CB. High fat diet worsens Alzheimer's disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow. Scientific Reports. 10: 9884. PMID 32555372 DOI: 10.1038/S41598-020-65908-Y  0.785
2020 Ahn SJ, Ruiz-Uribe NE, Li B, Porter J, Sakadzic S, Schaffer CB. Label-free assessment of hemodynamics in individual cortical brain vessels using third harmonic generation microscopy. Biomedical Optics Express. 11: 2665-2678. PMID 32499951 DOI: 10.1364/Boe.385848  0.46
2019 Zhang Y, Bander ED, Lee Y, Muoser C, Schaffer CB, Nishimura N. Microvessel occlusions alter amyloid-beta plaque morphology in a mouse model of Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19889092. PMID 31744388 DOI: 10.1177/0271678X19889092  0.615
2019 Macknik SL, Alexander RG, Caballero O, Chanovas J, Nielsen KJ, Nishimura N, Schaffer CB, Slovin H, Babayoff A, Barak R, Tang S, Ju N, Yazdan-Shahmorad A, Alonso JM, Malinskiy E, et al. Advanced Circuit and Cellular Imaging Methods in Nonhuman Primates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 39: 8267-8274. PMID 31619496 DOI: 10.1523/Jneurosci.1168-19.2019  0.62
2019 Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, et al. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. International Journal of Stroke : Official Journal of the International Stroke Society. 1747493019871915. PMID 31543058 DOI: 10.1177/1747493019871915  0.604
2019 Bracko O, Njiru BN, Swallow M, Ali M, Haft-Javaherian M, Schaffer CB. Increasing cerebral blood flow improves cognition into late stages in Alzheimer's disease mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19873658. PMID 31495298 DOI: 10.1177/0271678X19873658  0.806
2019 Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, et al. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 961-984. PMID 31327392 DOI: 10.1016/J.Jalz.2019.06.001  0.604
2019 Smith AF, Doyeux V, Berg M, Peyrounette M, Haft-Javaherian M, Larue AE, Slater JH, Lauwers F, Blinder P, Tsai P, Kleinfeld D, Schaffer CB, Nishimura N, Davit Y, Lorthois S. Brain Capillary Networks Across Species: A few Simple Organizational Requirements Are Sufficient to Reproduce Both Structure and Function. Frontiers in Physiology. 10: 233. PMID 30971935 DOI: 10.3389/Fphys.2019.00233  0.77
2019 Haft-Javaherian M, Fang L, Muse V, Schaffer CB, Nishimura N, Sabuncu MR. Deep convolutional neural networks for segmenting 3D in vivo multiphoton images of vasculature in Alzheimer disease mouse models. Plos One. 14: e0213539. PMID 30865678 DOI: 10.1371/Journal.Pone.0213539  0.797
2019 Cruz Hernández JC, Bracko O, Kersbergen CJ, Muse V, Haft-Javaherian M, Berg M, Park L, Vinarcsik LK, Ivasyk I, Rivera DA, Kang Y, Cortes-Canteli M, Peyrounette M, Doyeux V, Smith A, ... ... Schaffer CB, et al. Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models. Nature Neuroscience. PMID 30742116 DOI: 10.1038/S41593-018-0329-4  0.811
2019 Chan S, Brophy M, Nishimura N, Schaffer CB. Aspirin treatment does not increase microhemorrhage size in young or aged mice. Plos One. 14: e0204295. PMID 30608925 DOI: 10.1371/Journal.Pone.0204295  0.638
2019 Bracko O, Nishimura N, Schaffer CB. Unexpectedly stalled: the dynamics of brain blood flow in Alzheimer’s disease Thesciencebreaker. 5. DOI: 10.25250/thescbr.brk263  0.644
2019 Haft-Javaherian M, Schaffer CB, Nishimura N, Sabuncu MR. Comparison of convolutional neural and fully convolutional networks for segmentation of 3D in vivo multiphoton microscopy images of brain vasculature Brain. DOI: 10.1364/Brain.2019.Bt2A.4  0.786
2018 Koizumi K, Hattori Y, Ahn SJ, Buendia I, Ciacciarelli A, Uekawa K, Wang G, Hiller A, Zhao L, Voss HU, Paul SM, Schaffer C, Park L, Iadecola C. Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function. Nature Communications. 9: 3816. PMID 30232327 DOI: 10.1038/S41467-018-06301-2  0.434
2018 Nagappan S, Liu L, Fetcho R, Nguyen J, Nishimura N, Radwanski RE, Lieberman S, Baird-Daniel E, Ma H, Zhao M, Schaffer CB, Schwartz TH. In Vivo Femtosecond Laser Subsurface Cortical Microtransections Attenuate Acute Rat Focal Seizures. Cerebral Cortex (New York, N.Y. : 1991). PMID 30192931 DOI: 10.1093/Cercor/Bhy210  0.59
2018 Ahn SJ, Anrather J, Nishimura N, Schaffer CB. Diverse Inflammatory Response After Cerebral Microbleeds Includes Coordinated Microglial Migration and Proliferation. Stroke. PMID 29844029 DOI: 10.1161/Strokeaha.117.020461  0.622
2017 Erdener ŞE, Tang J, Sajjadi A, Kılıç K, Kura S, Schaffer CB, Boas DA. Spatio-temporal dynamics of cerebral capillary segments with stalling red blood cells. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17743877. PMID 29168661 DOI: 10.1177/0271678X17743877  0.424
2017 Bollu T, Cornelius NR, Sunwoo J, Nishimura N, Schaffer CB, Doerschuk PC. Experimentally constrained circuit model of cortical arteriole networks for understanding flow redistribution due to occlusion and neural activation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17741086. PMID 29130779 DOI: 10.1177/0271678X17741086  0.814
2017 Hernández JCC, Bracko O, Kersbergen C, Muse V, Haft-Javaherian M, Ivasyk I, Park L, Vinarcsik L, Kang Y, Zhou J, Beverly JD, Slack E, Otte G, Santisakultarm TP, Iadecola C, ... ... Schaffer CB, et al. Two-Photon Imaging Reveals Capillary Occlusions are Responsible for Reduced Brain Blood Flow and Cognitive Decline in Alzheimer’s Disease Mouse Models Brain. DOI: 10.1364/Brain.2017.Brw3B.3  0.808
2017 Pender MA, Lin K, Bares A, Kaplitt MG, Schaffer CB, Nishimura N. Multicolor Genetically-Encoded Calcium-Sensitive Bioluminescent Reporters of Neural Activity for Brain-Machine Interfaces Brain. DOI: 10.1364/Brain.2017.Brtu2B.3  0.597
2016 Koyama M, Minale F, Shum J, Nishimura N, Schaffer CB, Fetcho JR. A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right. Elife. 5. PMID 27502742 DOI: 10.7554/Elife.16808  0.774
2016 Koyama M, Minale F, Shum J, Nishimura N, Schaffer CB, Fetcho JR. Author response: A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right Elife. DOI: 10.7554/Elife.16808.017  0.749
2016 Cheng Y, Ness SL, Hu SH, Raikin J, Pan LD, Wang T, Ouzounov DG, Cruz-Hernandez JC, Bastille IM, Nishimura N, Fetcho JR, Xu C, Schaffer CB. In-Vivo Three-Photon Excited Fluorescence Imaging in the Spinal Cord of Awake, Locomoting Mouse Frontiers in Optics. DOI: 10.1364/Fio.2016.Jth2A.183  0.775
2016 Ahn SJ, Anrather J, Nishimura N, Schaffer CB. The inflammatory response following a laser-induced cortical microhemorrhage in a rodent model is dominated by brain-resident microglia and not blood-borne macrophages Cancer. DOI: 10.1364/Cancer.2016.Jw3A.24  0.656
2016 Ness SL, Cheng YT, Li X, Cruz-Hernandez JC, Wang T, Ouzounov DG, Raikin J, Pan LD, Hu SH, Bastille IM, Nishimura N, Fetcho JR, Xu C, Schaffer CB. In-Vivo Three-Photon Excited Fluorescence Microscopy of the Spinal Cord in the Awake, Locomoting Mouse Brain. DOI: 10.1364/Brain.2016.Bw4B.4  0.773
2016 Cruz Hernandez JC, Kersbergen C, Muse V, Ivasyk I, Bracko O, Haft-Javaherian M, Kang Y, Zhou J, Beverly JD, Slack E, Otte G, Santisakultarm TP, Iadecola C, Nishimura N, Schaffer CB. P4-097: Stalled Blood flow in Brain Capillaries is Responsible for Reduced Cortical Perfusion in a Mouse Model of Alzheimer’s Disease Alzheimer's & Dementia. 12: P1049-P1050. DOI: 10.1016/J.Jalz.2016.06.2186  0.806
2015 Cohen R, Lata JP, Lee Y, Hernández JC, Nishimura N, Schaffer CB, Mukai C, Nelson JL, Brangman SA, Agrawal Y, Travis AJ. Use of Tethered Enzymes as a Platform Technology for Rapid Analyte Detection. Plos One. 10: e0142326. PMID 26605916 DOI: 10.1371/Journal.Pone.0142326  0.587
2015 Tsai PS, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D. Ultra-large field-of-view two-photon microscopy. Optics Express. 23: 13833-47. PMID 26072755 DOI: 10.1364/Oe.23.013833  0.787
2015 Shih AY, Rühlmann C, Blinder P, Devor A, Drew PJ, Friedman B, Knutsen PM, Lyden PD, Matéo C, Mellander L, Nishimura N, Schaffer CB, Tsai PS, Kleinfeld D. Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture. Microcirculation (New York, N.Y. : 1994). 22: 204-18. PMID 25705966 DOI: 10.1111/Micc.12195  0.812
2015 Farrar MJ, Rubin JD, Diago DM, Schaffer CB. Characterization of blood flow in the mouse dorsal spinal venous system before and after dorsal spinal vein occlusion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 667-75. PMID 25564237 DOI: 10.1038/Jcbfm.2014.244  0.705
2015 Lindsey SE, Menon PG, Kowalski WJ, Shekhar A, Yalcin HC, Nishimura N, Schaffer CB, Butcher JT, Pekkan K. Growth and hemodynamics after early embryonic aortic arch occlusion. Biomechanics and Modeling in Mechanobiology. 14: 735-51. PMID 25416845 DOI: 10.1007/S10237-014-0633-1  0.621
2015 Tsai PS, Mateo C, Field JJ, Schaffer CB, Anderson ME, Kleinfeld D. Ultra-large field-of-view two-photon microscopy Optics Express. 23: 13833-13847. DOI: 10.1364/OE.23.013833  0.764
2015 Schaffer CB. In Vivo Imaging of Cell Dynamics in Animal Models of Neurological Disease using Nonlinear Microscopy Frontiers in Optics. DOI: 10.1364/Fio.2015.Ftu2D.1  0.402
2014 Farrar MJ, Schaffer CB. A procedure for implanting a spinal chamber for longitudinal in vivo imaging of the mouse spinal cord. Journal of Visualized Experiments : Jove. PMID 25548864 DOI: 10.3791/52196  0.639
2014 Murphy PA, Kim TN, Huang L, Nielsen CM, Lawton MT, Adams RH, Schaffer CB, Wang RA. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. Proceedings of the National Academy of Sciences of the United States of America. 111: 18007-12. PMID 25468970 DOI: 10.1073/Pnas.1415316111  0.424
2014 Santisakultarm TP, Paduano CQ, Stokol T, Southard TL, Nishimura N, Skoda RC, Olbricht WL, Schafer AI, Silver RT, Schaffer CB. Stalled cerebral capillary blood flow in mouse models of essential thrombocythemia and polycythemia vera revealed by in vivo two-photon imaging. Journal of Thrombosis and Haemostasis : Jth. 12: 2120-30. PMID 25263265 DOI: 10.1111/Jth.12738  0.8
2014 Schaffer CB. FTS-02-01: LEUKOCYTE PLUGGING OF CAPILLARIES REDUCES BRAIN BLOOD FLOW IN MOUSE MODELS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P285-P285. DOI: 10.1016/J.Jalz.2014.04.470  0.443
2013 Horton NG, Wang K, Kobat D, Clark CG, Wise FW, Schaffer CB, Xu C. In vivo three-photon microscopy of subcortical structures within an intact mouse brain. Nature Photonics. 7. PMID 24353743 DOI: 10.1038/Nphoton.2012.336  0.589
2013 Shih AY, Nishimura N, Nguyen J, Friedman B, Lyden PD, Schaffer CB, Kleinfeld D. Optically induced occlusion of single blood vessels in rodent neocortex. Cold Spring Harbor Protocols. 2013: 1153-60. PMID 24298038 DOI: 10.1101/Pdb.Prot079509  0.818
2013 Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, ... ... Schaffer CB, et al. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 80: 270-4. PMID 24139032 DOI: 10.1016/J.Neuron.2013.09.008  0.648
2013 Davis AA, Farrar MJ, Nishimura N, Jin MM, Schaffer CB. Optoporation and genetic manipulation of cells using femtosecond laser pulses. Biophysical Journal. 105: 862-71. PMID 23972838 DOI: 10.1016/J.Bpj.2013.07.012  0.748
2013 Cianchetti FA, Kim DH, Dimiduk S, Nishimura N, Schaffer CB. Stimulus-evoked calcium transients in somatosensory cortex are temporarily inhibited by a nearby microhemorrhage. Plos One. 8: e65663. PMID 23724147 DOI: 10.1371/Journal.Pone.0065663  0.782
2013 Nishimura N, Schaffer CB. Big effects from tiny vessels: imaging the impact of microvascular clots and hemorrhages on the brain. Stroke; a Journal of Cerebral Circulation. 44: S90-2. PMID 23709743 DOI: 10.1161/Strokeaha.112.679621  0.679
2013 Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. Plos One. 8: e54203. PMID 23408937 DOI: 10.1371/Journal.Pone.0054203  0.773
2013 Nishimura N, Kersbergen C, Ivasyk I, Cruz J, Zhou J, Beverly J, Otte G, Karlsson P, Slack E, Santisakultarm TP, Iadecola C, Schaffer C. P1-035: Stalled blood flow in cortical capillaries, caused by recurrent plugging by leukocytes, contributes to brain blood flow reductions in mouse models of Alzheimer's disease Alzheimer's & Dementia. 9: P164-P165. DOI: 10.1016/J.Jalz.2013.05.255  0.825
2012 Kim TN, Goodwill PW, Chen Y, Conolly SM, Schaffer CB, Liepmann D, Wang RA. Line-scanning particle image velocimetry: an optical approach for quantifying a wide range of blood flow speeds in live animals. Plos One. 7: e38590. PMID 22761686 DOI: 10.1371/Journal.Pone.0038590  0.454
2012 Shih AY, Driscoll JD, Drew PJ, Nishimura N, Schaffer CB, Kleinfeld D. Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 1277-309. PMID 22293983 DOI: 10.1038/Jcbfm.2012.177  0.829
2012 Gould RA, Chin K, Santisakultarm TP, Dropkin A, Richards JM, Schaffer CB, Butcher JT. Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture. Acta Biomaterialia. 8: 1710-9. PMID 22281945 DOI: 10.1016/J.Actbio.2012.01.006  0.758
2012 Santisakultarm TP, Cornelius NR, Nishimura N, Schafer AI, Silver RT, Doerschuk PC, Olbricht WL, Schaffer CB. In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1367-77. PMID 22268102 DOI: 10.1152/Ajpheart.00417.2011  0.831
2012 Farrar MJ, Bernstein IM, Schlafer DH, Cleland TA, Fetcho JR, Schaffer CB. Chronic in vivo imaging in the mouse spinal cord using an implanted chamber. Nature Methods. 9: 297-302. PMID 22266542 DOI: 10.1038/Nmeth.1856  0.75
2012 Murphy PA, Kim TN, Lu G, Bollen AW, Schaffer CB, Wang RA. Notch4 normalization reduces blood vessel size in arteriovenous malformations. Science Translational Medicine. 4: 117ra8. PMID 22261032 DOI: 10.1126/Scitranslmed.3002670  0.431
2012 Foley CP, Nishimura N, Neeves KB, Schaffer CB, Olbricht WL. Real-time imaging of perivascular transport of nanoparticles during convection-enhanced delivery in the rat cortex. Annals of Biomedical Engineering. 40: 292-303. PMID 22009318 DOI: 10.1007/S10439-011-0440-0  0.619
2012 Jones J, Chowdhury R, Jalloh D, Seo BK, Pandya JK, Schaffer CB, Nishimura N. In-vivo imaging of beating mouse heart with multiphoton microscopy Frontiers in Optics, Fio 2012. DOI: 10.1364/Fio.2012.Fm4D.6  0.646
2011 Sunwoo J, Cornelius NR, Doerschuk PC, Schaffer CB. Estimating brain microvascular blood flows from partial two-photon microscopy data by computation with a circuit model. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2011: 174-7. PMID 22254278 DOI: 10.1109/IEMBS.2011.6089922  0.368
2011 Huynh J, Nishimura N, Rana K, Peloquin JM, Califano JP, Montague CR, King MR, Schaffer CB, Reinhart-King CA. Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Science Translational Medicine. 3: 112ra122. PMID 22158860 DOI: 10.1126/Scitranslmed.3002761  0.599
2011 Rosidi NL, Zhou J, Pattanaik S, Wang P, Jin W, Brophy M, Olbricht WL, Nishimura N, Schaffer CB. Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. Plos One. 6: e26612. PMID 22028924 DOI: 10.1371/Journal.Pone.0026612  0.822
2011 Zhao M, Nguyen J, Ma H, Nishimura N, Schaffer CB, Schwartz TH. Preictal and ictal neurovascular and metabolic coupling surrounding a seizure focus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13292-300. PMID 21917812 DOI: 10.1523/Jneurosci.2597-11.2011  0.655
2011 Lauer A, Cianchetti FA, Van Cott EM, Schlunk F, Schulz E, Pfeilschifter W, Steinmetz H, Schaffer CB, Lo EH, Foerch C. Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation. 124: 1654-62. PMID 21911784 DOI: 10.1161/Circulationaha.111.035972  0.788
2011 Nguyen J, Nishimura N, Fetcho RN, Iadecola C, Schaffer CB. Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 2243-54. PMID 21712834 DOI: 10.1038/Jcbfm.2011.95  0.713
2011 Nguyen J, Ferdman J, Zhao M, Huland D, Saqqa S, Ma J, Nishimura N, Schwartz TH, Schaffer CB. Sub-surface, micrometer-scale incisions produced in rodent cortex using tightly-focused femtosecond laser pulses. Lasers in Surgery and Medicine. 43: 382-91. PMID 21674543 DOI: 10.1002/Lsm.21054  0.783
2011 Santisakultarm TP, Schaffer CB. Optically quantified cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1337-8. PMID 21364601 DOI: 10.1038/Jcbfm.2011.18  0.827
2011 Farrar MJ, Wise FW, Fetcho JR, Schaffer CB. In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy. Biophysical Journal. 100: 1362-71. PMID 21354410 DOI: 10.1016/J.Bpj.2011.01.031  0.755
2011 Stokol T, Esch MB, Nishimura N, Schaffer C, Daddona JL, Post DJ, Desai DP. Little channels, big disease: Using microfluidics to investigate cancer metastasis Asme 2011 9th International Conference On Nanochannels, Microchannels, and Minichannels, Icnmm 2011. 2: 655-661. DOI: 10.1115/ICNMM2011-58298  0.51
2010 Nishimura N, Rosidi NL, Iadecola C, Schaffer CB. Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1914-27. PMID 20842163 DOI: 10.1038/Jcbfm.2010.157  0.821
2010 Yalcin HC, Shekhar A, Nishimura N, Rane AA, Schaffer CB, Butcher JT. Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects. American Journal of Physiology. Heart and Circulatory Physiology. 299: H1728-35. PMID 20709864 DOI: 10.1152/Ajpheart.00495.2010  0.627
2010 Cianchetti FA, Nishimura N, Schaffer CB. Stimulus-evoked calcium transients in somatosensory cortex are inhibited after a nearby microhemorrhage Optics Infobase Conference Papers. DOI: 10.1364/Biomed.2010.Jma93  0.786
2010 Nguyen J, Nishimura N, Iadecola C, Schaffer CB. Femtosecond Laser Ablation to Induce Occlusions in Single, Targeted Venules in Rat Brain Ieee Transactions On Biomedical Engineering. DOI: 10.1364/Biomed.2010.Bmc6  0.683
2010 Farrar MJ, Renninger W, Fetcho JR, Wise FW, Schaffer CB. Third Harmonic Generation As a Novel Technique for Imaging Myelin in the Central Nervous System Ieee Transactions On Biomedical Engineering. DOI: 10.1364/Biomed.2010.Bmc2  0.756
2010 Santisakultarm TP, Nishimura N, Paduano C, Skoda RC, Olbricht WL, Schafer AI, Schaffer CB, Silver RT. In Vivo Imaging of Cerebral Circulation In Mouse Models of Polycythemia Vera Blood. 116: 4091-4091. DOI: 10.1182/Blood.V116.21.4091.4091  0.812
2010 Kobat D, Durst ME, Nishimura N, Wong AW, Schaffer CB, Xu C. In vivo deep tissue imaging with long wavelength multiphoton excitation Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7569. DOI: 10.1117/12.842292  0.73
2010 Wise FW, Renninger W, Lefrancois S, Kieu K, Farrar M, Schaffer C, Saar B, Holtom G, Xie S. Short-pulse fiber lasers for Raman microscopies Progress in Biomedical Optics and Imaging - Proceedings of Spie. 7569. DOI: 10.1117/12.841406  0.607
2009 Kobat D, Durst ME, Nishimura N, Wong AW, Schaffer CB, Xu C. Deep tissue multiphoton microscopy using longer wavelength excitation. Optics Express. 17: 13354-64. PMID 19654740 DOI: 10.1364/Oe.17.013354  0.745
2009 Foley CP, Nishimura N, Neeves KB, Schaffer CB, Olbricht WL. Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery. Biomedical Microdevices. 11: 915-24. PMID 19353271 DOI: 10.1007/S10544-009-9308-6  0.581
2008 Shum J, Nishimura N, Fetcho JR, Schaffer CB. Ablation of the mauthner cell lateral dendrite using femtosecond laser pulses Optics Infobase Conference Papers. DOI: 10.1364/Fio.2008.Ftul2  0.776
2008 Nishimura N, Zhou J, Iadecola C, Schaffer CB. Femtosecond laser-induced microvascular clots trigger alzheimer's disease pathology Optics Infobase Conference Papers. DOI: 10.1364/Fio.2008.Ftue4  0.695
2008 Nguyen J, Nishimura N, Iadecola C, Schaffer CB. Femtosecond laser-driven photodisruption to induce single venule occlusions in rodent brain Optics Infobase Conference Papers. DOI: 10.1364/Fio.2008.Ftue3  0.708
2008 Wang P, Foley CP, Nishimura N, Schaffer C, Olbricht WL. Convection-enhanced transport of polymeric nanoparticles in the perivascular space of the brain Aiche Annual Meeting, Conference Proceedings 0.532
2007 Clay GO, Schaffer CB, Kleinfeld D. Large two-photon absorptivity of hemoglobin in the infrared range of 780-880 nm. The Journal of Chemical Physics. 126: 025102. PMID 17228976 DOI: 10.1063/1.2404678  0.759
2007 Nishimura N, Schaffer CB, Friedman B, Lyden PD, Kleinfeld D. Penetrating arterioles are a bottleneck in the perfusion of neocortex. Proceedings of the National Academy of Sciences of the United States of America. 104: 365-70. PMID 17190804 DOI: 10.1073/Pnas.0609551104  0.803
2006 Nishimura N, Schaffer CB, Friedman B, Tsai PS, Lyden PD, Kleinfeld D. Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: three models of stroke. Nature Methods. 3: 99-108. PMID 16432519 DOI: 10.1038/Nmeth844  0.834
2006 Schaffer CB, Friedman B, Nishimura N, Schroeder LF, Tsai PS, Ebner FF, Lyden PD, Kleinfeld D. Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. Plos Biology. 4: e22. PMID 16379497 DOI: 10.1371/Journal.Pbio.0040022  0.826
2006 Clay GO, Millard AC, Schaffer CB, Aus-der-Au J, Tsai PS, Squier JA, Kleinfeld D. Spectroscopy of third-harmonic generation: Evidence for resonances in model compounds and ligated hemoglobin Journal of the Optical Society of America B: Optical Physics. 23: 932-950. DOI: 10.1364/Josab.23.000932  0.758
2006 Nishimura N, Schaffer CB, Kleinfeld D. In vivo manipulation of biological systems with femtosecond laser pulses Proceedings of Spie - the International Society For Optical Engineering. 6261. DOI: 10.1117/12.668886  0.73
2006 Clay O, Schaffer CB, Squier JA, Kleinfeld D. Ultrafast third harmonic micro-spectroscopy reveals a two-photon resonance in human hemoglobin Proceedings of Spie - the International Society For Optical Engineering. 6108. DOI: 10.1117/12.659110  0.664
2006 Bracko O, Cruz Hernandez JC, Vinarcsik LK, Ali M, Swallow M, Zheng J, Njiru BN, Nishimura N, Schaffer CB. P2-212: HIGH FAT DIET EXACERBATES CAPILLARY STALLING AND ALZHEIMER'S DISEASE-RELATED PATHOLOGY IN THE APP/PS1 MOUSE MODEL Alzheimer's & Dementia. 14: P749-P750. DOI: 10.1016/J.Jalz.2018.06.900  0.594
2006 Bracko O, Cruz Hernandez JC, Njiru BN, Swallow M, Zheng J, Ali M, Kersbergen C, Muse V, Haft-Javaherian M, Park L, Vinarcsik LK, Ivasyk I, Kang Y, Zhou J, Otte G, ... ... Schaffer CB, et al. O2-12-04: STALLED BLOOD FLOW IN BRAIN CAPILLARIES IS RESPONSIBLE FOR REDUCED CORTICAL PERFUSION AND IMPACTS COGNITIVE FUNCTION IN MOUSE MODELS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P651-P652. DOI: 10.1016/J.Jalz.2018.06.2709  0.806
2005 Kim TN, Campbell K, Groisman A, Kleinfeld D, Schaffer CB. Femtosecond laser-drilled capillary integrated into a microfluidic device Applied Physics Letters. 86: 1-3. DOI: 10.1063/1.1926423  0.66
2004 Nishimura N, Schaffer CB, Friedman B, Tsai PS, Lyden PD, Kleinfeld D. Targeted disruption of deep-lying neocortical microvessels in rat using ultrashort laser pulses Proceedings of Spie - the International Society For Optical Engineering. 5340: 179-187. DOI: 10.1117/12.555404  0.816
2004 Schaffer CB, Kim TN, Garcia JF, Mazur E, Groisman A, Kleinfeld D. Micromachining of bulk transparent materials using nanojoule femtosecond laser pulses Proceedings of Spie - the International Society For Optical Engineering. 5273: 469-471. DOI: 10.1117/12.525443  0.617
2004 Ifarraguerri A, Thompson B, Tsai PS, Friedman B, Schaffer CB, Lev-Ram V, Tsien RY, Squier JA, Kleinfeld D. Quantitative analysis of volumetric TPLSM data 2004 2nd Ieee International Symposium On Biomedical Imaging: Macro to Nano. 1: 804-807.  0.663
2003 Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. All-optical histology using ultrashort laser pulses. Neuron. 39: 27-41. PMID 12848930 DOI: 10.1016/S0896-6273(03)00370-2  0.746
2003 Schaffer CB, Ebner FF, Nishimura N, Friedman B, Tsai PS, Schroeder LF, Lyden PD, Kleinfeld D. Two-photon fluorescence microscopy of collateral blood flow following photothrombotic stroke in rat neocortex Frontiers in Optics. DOI: 10.1364/Fio.2003.Thpp2  0.825
2003 Kim TM, Groisman A, Kleinfeld D, Schaffer CB. Customization of microfluidic devices using femtosecond laser micromachining Frontiers in Optics. DOI: 10.1364/Fio.2003.Thcc4  0.646
2003 Schaffer CB, Tsai PS, Nishimura N, Schroeder LF, Friedman B, Lyden PD, Ebner FF, Kleinfeld D. All optical thrombotic stroke model for near-surface blood vessels in rat: Focal illumination of exogenous photosensitizers combined with real-time two-photon imaging Proceedings of Spie - the International Society For Optical Engineering. 4978: 222-231. DOI: 10.1117/12.484208  0.832
2003 Schaffer CB, Ebner FF, Nishimura N, Friedman B, Tsai PS, Schroeder LF, Lyden PD, Kleinfeld D. Real-time two-photon fluorescence microscopy of blood flow dynamics following photothrombotic stroke in rat neocortex Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-Leos. 1: 307-308.  0.797
2003 Tsai PS, Friedman B, Ifarraguerri AI, Thompson BD, Lev-Ram V, Schaffer CB, Xiong Q, Tsien RY, Squier JA, Kleinfeld D. All optical histology: Serial ablation and multiphoton imaging of neuronal tissue with femtosecond laser pulses Conference Proceedings - Lasers and Electro-Optics Society Annual Meeting-Leos. 2: 485-486.  0.716
2002 Schaffer C, Nishimura N, Glezer E, Kim A, Mazur E. Dynamics of femtosecond laser-induced breakdown in water from femtoseconds to microseconds. Optics Express. 10: 196-203. PMID 19424350 DOI: 10.1364/Oe.10.000196  0.609
2002 Schaffer CB, Der Au JA, Mazur E, Squier JA. Micromachining and material change characterization using femtosecond laser oscillators Proceedings of Spie - the International Society For Optical Engineering. 4633: 112-118. DOI: 10.1117/12.461370  0.327
2002 Schaffer CB, Nishimura N, Glezer EN, Kim AMT, Mazur E. Dynamics of femtosecond laser-induced breakdown in water from femtoseconds to microseconds Optics Express. 10: 196-203.  0.557
2001 Schaffer CB, Brodeur A, Mazur E. Laser-induced breakdown and damage in bulk transparent materials induced by tightly focused femtosecond laser pulses Measurement Science and Technology. 12: 1784-1794. DOI: 10.1088/0957-0233/12/11/305  0.303
1999 Schaffer CB, Brodeur A, Nishimura N, Mazur E. Microscopic bulk damage in dielectric materials using nanojoule femtosecond laser pulses Iqec, International Quantum Electronics Conference Proceedings. 232.  0.561
1998 Schaffer CB, Glezer EN, Nishimura N, Mazur E. Ultrafast laser-induced microexplosions: explosive dynamics and submicrometer structures High-Power Lasers and Applications. 3269: 36-45. DOI: 10.1117/12.312339  0.609
1998 Nishimura N, Schaffer CB, Li EH, Mazur E. Tissue ablation with 100-fs and 200-ps laser pulses Annual International Conference of the Ieee Engineering in Medicine and Biology - Proceedings. 4: 1703-1706.  0.57
1997 Glezer EN, Schaffer CB, Nishimura N, Mazur E. Minimally disruptive laser-induced breakdown in water. Optics Letters. 22: 1817-9. PMID 18188376 DOI: 10.1364/Ol.22.001817  0.611
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