Berislav V. Zlokovic - Publications

Affiliations: 
University of Rochester, Rochester, NY 
Area:
Neuroscience Biology, Cell Biology

220 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. PMID 31523028 DOI: 10.1016/j.stem.2019.08.005  0.36
2019 Shi Y, Hung ST, Rocha G, Lin S, Linares G, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. Jci Insight. 5. PMID 31310593 DOI: 10.1172/jci.insight.127736  0.52
2019 Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, ... Zlokovic BV, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nature Neuroscience. 22: 1089-1098. PMID 31235908 DOI: 10.1038/s41593-019-0434-z  0.52
2019 Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Reports. 27: 549-560.e6. PMID 30970257 DOI: 10.1016/j.celrep.2018.12.055  0.36
2019 Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends in Molecular Medicine. PMID 30661727 DOI: 10.1016/j.molmed.2019.01.001  0.52
2019 Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. The Journal of Experimental Medicine. PMID 30647119 DOI: 10.1084/jem.20181035  0.52
2019 Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, ... ... Zlokovic BV, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine. PMID 30643288 DOI: 10.1038/s41591-018-0297-y  0.52
2019 Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, ... ... Zlokovic BV, et al. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 158-167. PMID 30642436 DOI: 10.1016/j.jalz.2018.07.222  0.52
2019 Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. Blood-Brain Barrier: From Physiology to Disease and Back. Physiological Reviews. 99: 21-78. PMID 30280653 DOI: 10.1152/physrev.00050.2017  0.52
2018 Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, ... ... Zlokovic BV, et al. Final Results of the RHAPSODY trial: A multi-center, Phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a Recombinant Variant of Human Activated Protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke. Annals of Neurology. PMID 30450637 DOI: 10.1002/ana.25383  0.32
2018 Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Molecular Neurodegeneration. 13: 57. PMID 30340601 DOI: 10.1186/s13024-018-0286-0  0.52
2018 Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nature Neuroscience. 21: 1318-1331. PMID 30250261 DOI: 10.1038/s41593-018-0234-x  0.36
2018 Sweeney MD, Zlokovic BV. A lymphatic waste-disposal system implicated in Alzheimer's disease. Nature. 560: 172-174. PMID 30076374 DOI: 10.1038/d41586-018-05763-0  0.36
2018 Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C, protease activated receptor 1 and neuroprotection. Blood. PMID 29866816 DOI: 10.1182/blood-2018-02-769026  0.32
2018 Kisler K, Lazic D, Sweeney MD, Plunkett S, El Khatib M, Vinogradov SA, Boas DA, Sakadži S, Zlokovic BV. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. Nature Protocols. 13: 1377-1402. PMID 29844521 DOI: 10.1038/nprot.2018.034  0.36
2018 Russin JJ, Montagne A, D'Amore F, He S, Shiroishi MS, Rennert RC, Depetris J, Zlokovic BV, Mack WJ. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18768670. PMID 29611451 DOI: 10.1177/0271678X18768670  0.36
2018 Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, ... ... Zlokovic BV, et al. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature Medicine. PMID 29400714 DOI: 10.1038/nm.4490  0.52
2018 Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, ... ... Zlokovic BV, et al. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nature Medicine. PMID 29400711 DOI: 10.1038/nm.4482  0.52
2018 Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews. Neurology. 14: 133-150. PMID 29377008 DOI: 10.1038/nrneurol.2017.188  0.52
2018 Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernandez JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke. Blood. PMID 29343482 DOI: 10.1182/blood-2017-10-810895  0.36
2017 Montagne A, Zhao Z, Zlokovic BV. Alzheimer's disease: A matter of blood-brain barrier dysfunction? The Journal of Experimental Medicine. PMID 29061693 DOI: 10.1084/jem.20171406  0.36
2017 Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. PMID 28923278 DOI: 10.1016/j.neuropharm.2017.09.021  0.52
2017 Nelson AR, Sagare AP, Zlokovic BV. Role of clusterin in the brain vascular clearance of amyloid-β. Proceedings of the National Academy of Sciences of the United States of America. PMID 28765369 DOI: 10.1073/pnas.1711357114  0.52
2017 Zhao Z, Zlokovic BV. Remote control of BBB: A tale of exosomes and microRNA. Cell Research. 27: 849-850. PMID 28674430 DOI: 10.1038/cr.2017.71  0.36
2017 Kisler K, Nelson AR, Montagne A, Zlokovic BV. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nature Reviews. Neuroscience. PMID 28515434 DOI: 10.1038/nrn.2017.48  0.52
2017 Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. Plos One. 12: e0176225. PMID 28441414 DOI: 10.1371/journal.pone.0176225  0.36
2017 Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžić S, Zlokovic BV. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience. PMID 28135240 DOI: 10.1038/nn.4489  0.52
2016 Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27758767 DOI: 10.1161/ATVBAHA.116.308038  0.32
2016 Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nature Medicine. PMID 27548576 DOI: 10.1038/nm.4154  0.36
2016 Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. PMID 27524440 DOI: 10.1016/j.stem.2016.07.019  0.36
2016 Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience. 19: 771-83. PMID 27227366 DOI: 10.1038/nn.4288  0.36
2016 Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thrombosis Research. 141: S62-S64. PMID 27207428 DOI: 10.1016/S0049-3848(16)30368-1  0.32
2016 Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathologica. PMID 27038189 DOI: 10.1007/s00401-016-1570-0  0.52
2015 Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochimica Et Biophysica Acta. PMID 26705676 DOI: 10.1016/j.bbadis.2015.12.016  0.52
2015 Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 163: 1064-78. PMID 26590417 DOI: 10.1016/j.cell.2015.10.067  0.52
2015 Montagne A, Toga AW, Zlokovic BV. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. Jama Neurology. 1-2. PMID 26524294 DOI: 10.1001/jamaneurol.2015.2960  0.52
2015 Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neuroscience Letters. 607: 97-101. PMID 26407747 DOI: 10.1016/j.neulet.2015.09.025  0.52
2015 Amar AP, Griffin JH, Zlokovic BV. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Frontiers in Cellular Neuroscience. 9: 344. PMID 26388732 DOI: 10.3389/fncel.2015.00344  0.32
2015 Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Frontiers in Aging Neuroscience. 7: 136. PMID 26236233 DOI: 10.3389/fnagi.2015.00136  0.52
2015 Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, et al. Clearance systems in the brain-implications for Alzheimer disease. Nature Reviews. Neurology. PMID 26195256 DOI: 10.1038/nrneurol.2015.119  0.52
2015 Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine. PMID 26077645 DOI: 10.1002/mrm.25793  0.52
2015 Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. Bmc Medical Imaging. 15: 19. PMID 26076957 DOI: 10.1186/s12880-015-0062-3  0.52
2015 Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, ... ... Zlokovic BV, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nature Neuroscience. 18: 978-87. PMID 26005850 DOI: 10.1038/nn.4025  0.52
2015 Sweeney MD, Sagare AP, Zlokovic BV. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 1055-68. PMID 25899298 DOI: 10.1038/jcbfm.2015.76  0.52
2015 Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proceedings of Spie--the International Society For Optical Engineering. 9413. PMID 25859293 DOI: 10.1117/12.2081491  0.36
2015 Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 125: 2898-907. PMID 25824691 DOI: 10.1182/blood-2015-02-355974  0.52
2015 Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 25757756 DOI: 10.1038/jcbfm.2015.44  0.52
2015 Montagne A, Pa J, Zlokovic BV. Vascular plasticity and cognition during normal aging and dementia. Jama Neurology. 72: 495-6. PMID 25751405 DOI: 10.1001/jamaneurol.2014.4636  0.52
2015 Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, ... ... Zlokovic BV, et al. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience. 18: 521-30. PMID 25730668 DOI: 10.1038/nn.3966  0.52
2015 Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 85: 296-302. PMID 25611508 DOI: 10.1016/j.neuron.2014.12.032  0.52
2015 Daianu M, Jacobs RE, Zlokovic BV, Montagne A, Thompson PM. Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice Proceedings of Spie - the International Society For Optical Engineering. 9681. DOI: 10.1117/12.2207946  0.36
2015 Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, et al. Consensus statement for diagnosis of subcortical small vessel disease Journal of Cerebral Blood Flow and Metabolism. DOI: 10.1038/jcbfm.2015.172  0.52
2014 Mosnier LO, Zlokovic BV, Griffin JH. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thrombosis and Haemostasis. 112: 883-92. PMID 25230930 DOI: 10.1160/TH14-05-0448  0.52
2014 Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nature Communications. 5: 4820. PMID 25190485 DOI: 10.1038/ncomms5820  0.52
2014 Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, ... ... Zlokovic BV, et al. Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 83: 851-60. PMID 25080517 DOI: 10.1212/WNL.0000000000000733  0.52
2014 Winkler EA, Sagare AP, Zlokovic BV. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathology (Zurich, Switzerland). 24: 371-86. PMID 24946075 DOI: 10.1111/bpa.12152  0.52
2014 Zhao Z, Zlokovic BV. Blood-brain barrier: a dual life of MFSD2A? Neuron. 82: 728-30. PMID 24853933 DOI: 10.1016/j.neuron.2014.05.012  0.52
2014 Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proceedings of the National Academy of Sciences of the United States of America. 111: E1035-42. PMID 24591593 DOI: 10.1073/pnas.1401595111  0.52
2013 Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nature Communications. 4: 2932. PMID 24336108 DOI: 10.1038/ncomms3932  0.52
2013 Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke; a Journal of Cerebral Circulation. 44: 3529-36. PMID 24159062 DOI: 10.1161/STROKEAHA.113.003350  0.52
2013 Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. Journal of Thrombosis and Haemostasis : Jth. 11: 2059-62. PMID 24034518 DOI: 10.1111/jth.12400  0.52
2013 Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. Jama Neurology. 70: 1198-200. PMID 24030206 DOI: 10.1001/jamaneurol.2013.3841  0.52
2013 Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. The Journal of Biological Chemistry. 288: 15154-66. PMID 23580652 DOI: 10.1074/jbc.M112.439570  0.52
2013 Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6181-90. PMID 23554499 DOI: 10.1523/JNEUROSCI.4491-12.2013  0.52
2013 Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells, Molecules & Diseases. 51: 104-8. PMID 23541526 DOI: 10.1016/j.bcmd.2013.02.009  0.52
2013 Zlokovic BV. A gliovascular idea for the white matter repair? Journal of Neurochemistry. 125: 172-4. PMID 23441580 DOI: 10.1111/jnc.12174  0.52
2013 Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Research. 1507: 97-104. PMID 23438513 DOI: 10.1016/j.brainres.2013.02.023  0.52
2013 Zlokovic BV. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. Jama Neurology. 70: 440-4. PMID 23400708 DOI: 10.1001/jamaneurol.2013.2152  0.52
2013 Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathology (Zurich, Switzerland). 23: 303-10. PMID 23126372 DOI: 10.1111/bpa.12004  0.52
2013 Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathologica. 125: 111-20. PMID 22941226 DOI: 10.1007/s00401-012-1039-8  0.52
2013 Sagare AP, Bell RD, Zlokovic BV. Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: S87-100. PMID 22751174 DOI: 10.3233/JAD-2012-129037  0.52
2012 Sagare AP, Bell RD, Zlokovic BV. Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23028132 DOI: 10.1101/cshperspect.a011452  0.52
2012 Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 15502-7. PMID 22927427 DOI: 10.1073/pnas.1206446109  0.52
2012 Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 1841-52. PMID 22850407 DOI: 10.1038/jcbfm.2012.113  0.52
2012 Sagare AP, Deane R, Zlokovic BV. Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacology & Therapeutics. 136: 94-105. PMID 22820095 DOI: 10.1016/j.pharmthera.2012.07.008  0.52
2012 Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke; a Journal of Cerebral Circulation. 43: 2444-9. PMID 22811462 DOI: 10.1161/STROKEAHA.112.658997  0.52
2012 Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Current Pharmaceutical Design. 18: 4215-22. PMID 22632606 DOI: 10.2174/138161212802430413  0.52
2012 Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 485: 512-6. PMID 22622580 DOI: 10.1038/nature11087  0.52
2012 Griffin JH, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. International Journal of Hematology. 95: 333-45. PMID 22477541 DOI: 10.1007/s12185-012-1059-0  0.52
2012 Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, ... Zlokovic BV, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 122: 1377-92. PMID 22406537 DOI: 10.1172/JCI58642  0.52
2011 Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nature Reviews. Neuroscience. 12: 723-38. PMID 22048062 DOI: 10.1038/nrn3114  0.52
2011 Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nature Neuroscience. 14: 1398-405. PMID 22030551 DOI: 10.1038/nn.2946  0.52
2011 Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. Journal of Neuroscience Research. 89: 967-8. PMID 21544850 DOI: 10.1002/jnr.22670  0.52
2011 Zhong Z, Winkler EA, Zlokovic BV. Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 12: 231-2; author reply . PMID 21413850 DOI: 10.3109/17482968.2011.565776  0.52
2011 Zlokovic BV, Griffin JH. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends in Neurosciences. 34: 198-209. PMID 21353711 DOI: 10.1016/j.tins.2011.01.005  0.52
2011 Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Molecular Neurodegeneration. 6: 13. PMID 21291561 DOI: 10.1186/1750-1326-6-13  0.52
2011 Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 25-34. PMID 21157031 DOI: 10.3233/JAD-2010-101248  0.52
2010 Zlokovic BV. Neurodegeneration and the neurovascular unit. Nature Medicine. 16: 1370-1. PMID 21135839 DOI: 10.1038/nm1210-1370  0.52
2010 Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15521-34. PMID 21084607 DOI: 10.1523/JNEUROSCI.4437-10.2010  0.52
2010 Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 68: 409-27. PMID 21040844 DOI: 10.1016/j.neuron.2010.09.043  0.52
2010 Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. Journal of Neurochemistry. 115: 1077-89. PMID 20854368 DOI: 10.1111/j.1471-4159.2010.07002.x  0.52
2010 Winkler EA, Bell RD, Zlokovic BV. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Molecular Neurodegeneration. 5: 32. PMID 20738866 DOI: 10.1186/1750-1326-5-32  0.52
2010 Walker CT, Marky AH, Petraglia AL, Ali T, Chow N, Zlokovic BV. Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Research. 1347: 125-31. PMID 20513369 DOI: 10.1016/j.brainres.2010.05.075  0.52
2010 Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 115: 4963-72. PMID 20348395 DOI: 10.1182/blood-2010-01-262386  0.52
2010 Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Research. 1317: 218-26. PMID 20043896 DOI: 10.1016/j.brainres.2009.11.084  0.52
2010 Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 66: 165-71; discussion 1. PMID 20023547 DOI: 10.1227/01.NEU.0000363148.49779.68  0.52
2010 Zlokovic BV. Blood-Brain Barrier and Neurovascular Mechanisms of Neurodegeneration and Injury Encyclopedia of Neuroscience. 265-271. DOI: 10.1016/B978-008045046-9.00491-5  0.52
2009 Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, ... ... Zlokovic BV, et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. The Journal of Clinical Investigation. 119: 3437-49. PMID 19841542 DOI: 10.1172/JCI38476  0.52
2009 Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 94: 1721-31. PMID 19815836 DOI: 10.3324/haematol.2009.009233  0.52
2009 Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathologica. 118: 103-13. PMID 19319544 DOI: 10.1007/s00401-009-0522-3  0.52
2009 Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. The European Journal of Neuroscience. 29: 1119-30. PMID 19302148 DOI: 10.1111/j.1460-9568.2009.06664.x  0.52
2009 Deane R, Bell RD, Sagare A, Zlokovic BV. Clearance of amyloid-β peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease Cns and Neurological Disorders - Drug Targets. 8: 16-30. PMID 19275634 DOI: 10.2174/187152709787601867  0.52
2009 Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. Journal of Neurochemistry. 109: 116-24. PMID 19166505 DOI: 10.1111/j.1471-4159.2009.05921.x  0.52
2009 Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology. 11: 143-53. PMID 19098903 DOI: 10.1038/ncb1819  0.52
2009 Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV. Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke; a Journal of Cerebral Circulation. 40: 1864-9. PMID 19057019 DOI: 10.1161/STROKEAHA.108.536680  0.52
2009 Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 25-33. PMID 18841163 DOI: 10.1038/jcbfm.2008.117  0.52
2008 Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12788-97. PMID 19036971 DOI: 10.1523/JNEUROSCI.3485-08.2008  0.52
2008 Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. The Journal of Clinical Investigation. 118: 4002-13. PMID 19033669 DOI: 10.1172/JCI36663  0.52
2008 Dearie R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Aβ clearance in Alzheimer's disease Current Pharmaceutical Design. 14: 1601-1605. PMID 18673201 DOI: 10.2174/138161208784705487  0.52
2008 Zlokovic BV. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 409-14. PMID 18625452 DOI: 10.1016/j.nurt.2008.05.011  0.52
2008 Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1505-10. PMID 18451334 DOI: 10.1161/ATVBAHA.108.166066  0.52
2008 Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience. 11: 420-2. PMID 18344992 DOI: 10.1038/nn2073  0.52
2008 Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57: 178-201. PMID 18215617 DOI: 10.1016/j.neuron.2008.01.003  0.52
2008 Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 764-71. PMID 17971789 DOI: 10.1038/sj.jcbfm.9600573  0.52
2007 Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, ... Zlokovic BV, et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine. 13: 1029-31. PMID 17694066 DOI: 10.1038/nm1635  0.52
2007 Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Current Alzheimer Research. 4: 191-7. PMID 17430246 DOI: 10.2174/156720507780362245  0.52
2007 Thiyagarajan M, Cheng T, Zlokovic BV. Endothelial cell protein C receptor: role beyond endothelium? Circulation Research. 100: 155-7. PMID 17272817 DOI: 10.1161/01.RES.0000258167.48227.84  0.52
2007 Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proceedings of the National Academy of Sciences of the United States of America. 104: 823-8. PMID 17215356 DOI: 10.1073/pnas.0608251104  0.52
2007 Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 109: 3161-72. PMID 17110453 DOI: 10.1182/blood-2006-09-003004  0.52
2007 Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 909-18. PMID 17077814 DOI: 10.1038/sj.jcbfm.9600419  0.52
2006 Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine. 12: 1278-85. PMID 17072311 DOI: 10.1038/nm1498  0.52
2006 Zlokovic BV. Remodeling after stroke. Nature Medicine. 12: 390-1. PMID 16598283 DOI: 10.1038/nm0406-390  0.52
2006 Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. The promise of protein C. Blood Cells, Molecules & Diseases. 36: 211-6. PMID 16464623 DOI: 10.1016/j.bcmd.2005.12.023  0.52
2005 Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11495-503. PMID 16354907 DOI: 10.1523/JNEUROSCI.3697-05.2005  0.52
2005 Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 115: 3285-90. PMID 16239972 DOI: 10.1172/JCI25247  0.52
2005 Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. Functional recovery after embolic stroke in rodents by activated protein C. Annals of Neurology. 58: 474-7. PMID 16130108 DOI: 10.1002/ana.20602  0.52
2005 Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, ... ... Zlokovic BV, et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine. 11: 959-65. PMID 16116430 DOI: 10.1038/nm1287  0.52
2005 Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends in Neurosciences. 28: 202-8. PMID 15808355 DOI: 10.1016/j.tins.2005.02.001  0.52
2005 Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain Pathology (Zurich, Switzerland). 15: 78-83. PMID 15779240  0.52
2005 Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. American Journal of Physiology. Cell Physiology. 289: C264-76. PMID 15743889 DOI: 10.1152/ajpcell.00461.2004  0.52
2005 Parsa AT, Lichtor T, Glick RP, Raffel C, Deane R, Zlokovic BV. Endothelial cell transplantation for gene therapy in experimental gliomas: Commentary Neurosurgery. 57: 1271.  0.52
2005 Zlokovic BV, Liu CY. Homologous transplantation of neural stem cells to the injured spinal cord of mice: Comments Neurosurgery. 57: 1024-1025.  0.52
2005 Marion DW, Zlokovic BV, Marshall LF. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury - Commentary Neurosurgery. 56: 604.  0.52
2004 Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine. 10: 1379-83. PMID 15516929 DOI: 10.1038/nm1122  0.52
2004 Deane R, Wu Z, Zlokovic BV. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke; a Journal of Cerebral Circulation. 35: 2628-31. PMID 15459432 DOI: 10.1161/01.STR.0000143452.85382.d1  0.52
2004 LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. Journal of Neuroscience Methods. 138: 233-42. PMID 15325132 DOI: 10.1016/j.jneumeth.2004.04.026  0.52
2004 Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, ... Zlokovic BV, et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 43: 333-44. PMID 15294142 DOI: 10.1016/j.neuron.2004.07.017  0.52
2004 Zlokovic BV. Clearing amyloid through the blood-brain barrier Journal of Neurochemistry. 89: 807-811. PMID 15140180 DOI: 10.1111/j.1471-4159.2004.02385.x  0.52
2004 Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Activated protein C and ischemic stroke. Critical Care Medicine. 32: S247-53. PMID 15118526  0.52
2004 Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. The Journal of Biological Chemistry. 279: 20296-306. PMID 14985348 DOI: 10.1074/jbc.M312946200  0.52
2004 Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 41: 563-72. PMID 14980205 DOI: 10.1016/S0896-6273(04)00019-4  0.52
2004 Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain Journal of Neurochemistry. 88: 813-820. PMID 14756801  0.52
2003 Wu Z, Hofman FM, Zlokovic BV. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. Journal of Neuroscience Methods. 130: 53-63. PMID 14583404 DOI: 10.1016/S0165-0270(03)00206-1  0.52
2003 Seki T, Hida K, Tada M, Koyanagi I, Iwasaki Y, Connolly ES, Rutka JT, Cheng T, Zlokovic BV. Role of the bcl-2 gene after contusive spinal cord injury in mice Neurosurgery. 53: 192-198. PMID 12823889  0.52
2003 Prins RM, Liau LM. Immunology and immunotherapy in neurosurgical disease. Neurosurgery. 53: 144-52; discussion 1. PMID 12823883  0.52
2003 Kapoor GS, O'Rourke DM, Piepmeier JM, Canute GW, Rutka JT, Zlokovic BV, Berger MS. Mitogenic signaling cascades in glial tumors Neurosurgery. 52: 1425-1435. PMID 12762887  0.52
2003 Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells, Molecules & Diseases. 30: 271-6. PMID 12737945 DOI: 10.1016/S1079-9796(03)00034-2  0.52
2003 Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 107: 1791-6. PMID 12665496 DOI: 10.1161/01.CIR.0000058460.34453.5A  0.52
2003 Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 101: 4797-801. PMID 12586611 DOI: 10.1182/blood-2002-12-3680  0.52
2003 Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine. 9: 338-42. PMID 12563316 DOI: 10.1038/nm826  0.52
2003 Amar AP, Zlokovic BV, Apuzzo MLJ, Neuwelt EA, Piepmeier JM, Grossman RG, Bendok BR, Hopkins LN. Endovascular restorative neurosurgery: A novel concept for molecular and cellular therapy of the nervous system Neurosurgery. 52: 402-413. PMID 12535371  0.52
2003 Boulis NM, Willmarth NE, Song DK, Feldman EL, Imperiale MJ. Intraneural colchicine inhibition of adenoviral and adeno-associated viral vector remote spinal cord gene delivery. Neurosurgery. 52: 381-7; discussion 38. PMID 12535368  0.52
2002 Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascular Pharmacology. 38: 303-13. PMID 12529925 DOI: 10.1016/S1537-1891(02)00198-2  0.52
2002 Zlokovic BV. Vascular disorder in Alzheimer's disease: Role in pathogenesis of dementia and therapeutic targets Advanced Drug Delivery Reviews. 54: 1553-1559. PMID 12453672 DOI: 10.1016/S0169-409X(02)00150-3  0.52
2002 Zlokovic BV. Advanced Drug Delivery Reviews: Preface Advanced Drug Delivery Reviews. 54: 1533-1537. PMID 12453670 DOI: 10.1016/S0169-409X(02)00147-3  0.52
2002 Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. American Journal of Physiology. Cell Physiology. 283: C895-904. PMID 12176746 DOI: 10.1152/ajpcell.00293.2001  0.52
2002 Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. Journal of Drug Targeting. 10: 359-68. PMID 12164385 DOI: 10.1080/10611860290031831  0.52
2002 Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiology of Aging. 23: 405-12. PMID 11959403 DOI: 10.1016/S0197-4580(01)00317-7  0.52
2002 Parney IF, Farr-Jones MA, Koshal A, Chang LJ, Petruk KC. Human brain tumor cell culture characterization after immunostimulatory gene transfer. Neurosurgery. 50: 1094-102. PMID 11950413 DOI: 10.1097/00006123-200205000-00027  0.52
2002 Kline DG, Zlokovic BV, Hodge CJ. Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: The histological representation of synkinesis. Comments Neurosurgery. 50: 362-363.  0.52
2001 Zlokovic BV, Cox C. Lower cognitive performance of older football players possessing apolipoprotein E ε4 [5] Neurosurgery. 48: 1196-1197. PMID 11334298  0.52
2001 Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures Journal of Neuroimmunology. 116: 62-73. PMID 11311331 DOI: 10.1016/S0165-5728(01)00280-6  0.52
2001 Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation. 103: 1799-1805. PMID 11282913  0.52
2001 MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. Preferential susceptibility of brain tumors to the antiangiogenic effects of an αv integrin antagonist Neurosurgery. 48: 151-157. PMID 11152340  0.52
2000 Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. The Journal of Clinical Investigation. 106: 1489-99. PMID 11120756 DOI: 10.1172/JCI10498  0.52
2000 Kudryk BJ, Bini A, Kumar SR, Zlokovic BV. Monoclonal antibody designated T2G1 reacts with human fibrin β-chain but not with the corresponding chain from mouse fibrin (multiple letters) Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1848-1849. PMID 10894828  0.52
2000 Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model Journal of Cerebral Blood Flow and Metabolism. 20: 998-1009. PMID 10894183  0.52
2000 Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nature Medicine. 6: 718-9. PMID 10888892 DOI: 10.1038/77397  0.52
2000 Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier Endocrinology. 141: 1434-1441. PMID 10746647 DOI: 10.1210/en.141.4.1434  0.52
1999 Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2801-6. PMID 10559029  0.52
1999 Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo MLJ, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells Neurosurgery. 45: 962-970. PMID 10515502 DOI: 10.1097/00006123-199910000-00072  0.52
1999 Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions Neuroscience Letters. 272: 127-130. PMID 10507558 DOI: 10.1016/S0304-3940(99)00592-3  0.52
1999 Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharmaceutical Research. 16: 1360-5. PMID 10496650 DOI: 10.1023/A:1018938722768  0.52
1999 Kannan R, Mackic JB, Zlokovic BV. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs Cornea. 18: 321-327. PMID 10336036 DOI: 10.1097/00003226-199905000-00014  0.52
1999 Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Experimental Neurology. 157: 194-201. PMID 10222122 DOI: 10.1006/exnr.1999.7052  0.52
1998 Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat brain capillary thrombomodulin: Structure and function Thrombosis Research. 92: 213-219. PMID 9851812 DOI: 10.1016/S0049-3848(98)00135-2  0.52
1998 MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein Neurosurgery. 43: 1437-1443. PMID 9848858  0.52
1998 Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain Neurosurgery. 43: 909-913. PMID 9766319 DOI: 10.1097/00006123-199810000-00107  0.52
1998 Zlokovic BV, Apuzzo MLJ. Strategies to circumvent vascular barriers of the central nervous system Neurosurgery. 43: 877-878. PMID 9766315 DOI: 10.1097/00006123-199810000-00089  0.52
1998 Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. The Journal of Clinical Investigation. 102: 734-43. PMID 9710442 DOI: 10.1172/JCI2029  0.52
1998 LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Human Gene Therapy. 9: 989-95. PMID 9607410 DOI: 10.1089/hum.1998.9.7-989  0.52
1998 Lavine SD, Hofman FM, Zlokovic BV. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury Journal of Cerebral Blood Flow and Metabolism. 18: 52-58. PMID 9428305  0.52
1998 Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. Journal of Neurochemistry. 70: 210-5. PMID 9422364  0.52
1998 Bullock MRR, Macrae IM, Graham DJ, Zlokovic BV, Tator CH. Posttraumatic cerebral ischemia after fluid percussion brain injury: An autoradiographic and histopathological study in rats: Commentaries Neurosurgery. 43: 593-594.  0.52
1998 Hodge J, Zlokovic BV, Mayberg MR, Findlay JM. Reactive oxygen species in reoxygenation injury of rat brain capillary endothelial cells: Commentaries Neurosurgery. 43: 584.  0.52
1997 Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. Thrombomodulin expression in bovine brain capillaries: Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3139-3146. PMID 9409303  0.52
1997 Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. Journal of Neurochemistry. 69: 1995-2004. PMID 9349544  0.52
1997 Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model Journal of Neurosurgery. 87: 731-737. PMID 9347982  0.52
1997 Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium Experimental Eye Research. 64: 615-626. PMID 9227280 DOI: 10.1006/exer.1996.0260  0.52
1997 Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs Current Eye Research. 16: 365-371. PMID 9134326  0.52
1997 Zlokovic BV, Apuzzo MLJ. Cellular and molecular neurosurgery: Pathways from concept to reality - Part II: Vector systems and delivery methodologies for gene therapy of the central nervous system Neurosurgery. 40: 805-813. PMID 9092854 DOI: 10.1097/00006123-199704000-00028  0.52
1997 Zlokovic BV, Apuzzo MLJ. Cellular and molecular neurosurgery: Pathways from concept to reality - Part I: Target disorders and concept approaches to gene therapy of the central nervous system Neurosurgery. 40: 789-804. PMID 9092853 DOI: 10.1097/00006123-199704000-00027  0.52
1997 Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats Journal of Cerebral Blood Flow and Metabolism. 17: 136-146. PMID 9040492  0.52
1997 Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharmaceutical Research. 14: 80-5. PMID 9034225 DOI: 10.1023/A:1012011618785  0.52
1997 Martel CL, Ghiso J, Frangione B, Zlokovic BV. Transport of apolipoproteins E and J at the blood-brain barrier: Relevance to Alzheimer's disease S.T.P. Pharma Sciences. 7: 28-36.  0.52
1996 Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharmaceutical Research. 13: 290-5. PMID 8932451 DOI: 10.1023/A:1016007601794  0.52
1996 Zlokovic BV. Cerebrovascular transport of Alzheimer's amyloid β and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier Life Sciences. 59: 1483-1497. PMID 8890929 DOI: 10.1016/0024-3205(96)00310-4  0.52
1996 Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. Cellular uptake and transport of methylprednisolone at the blood-brain barrier Neurosurgery. 38: 348-354. PMID 8869063 DOI: 10.1097/00006123-199602000-00023  0.52
1996 Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Investigative Ophthalmology & Visual Science. 37: 2269-75. PMID 8843923  0.52
1996 Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid β in guinea pigs Neuroscience Letters. 206: 157-160. PMID 8710175 DOI: 10.1016/S0304-3940(96)12462-9  0.52
1996 Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: Physiologic importance and manipulations Experimental Eye Research. 62: 29-37. PMID 8674510 DOI: 10.1006/exer.1996.0004  0.52
1996 Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences of the United States of America. 93: 4229-34. PMID 8633046  0.52
1996 Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. The Journal of Biological Chemistry. 271: 9754-8. PMID 8621654  0.52
1996 Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke; a Journal of Cerebral Circulation. 27: 712-9. PMID 8614937  0.52
1996 Mackic JB, Kaplowitz N, Kannan R, Zlokovic BV. Glutathione synthesis from circulating sulfur amino acids is a minor source for the lens epithelial glutathione Investigative Ophthalmology and Visual Science. 37.  0.52
1996 Kannan R, Yi YR, Zlokovic BV, Kaplowitz N. Molecular evidence for a novel, Na+-dependent GSH transporter in rat lens epithelium Investigative Ophthalmology and Visual Science. 37.  0.52
1996 Zlokovic BV, Mackic JB, Zigler JS, Kaplowitz N, Kannan R. Lens transport of ascorbic acid in guinea pigs, normal, galactose-fed and with congenital cataract Investigative Ophthalmology and Visual Science. 37.  0.52
1996 Mouw GJ, Giannotta SL, Weiss MH, DeGiorgio CM, Correale JD, Zlokovic BV. Effect of cerebral protection agents on neuron specific enolase in a rat stroke model Journal of Investigative Medicine. 44.  0.52
1995 Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism Methods and Findings in Experimental and Clinical Pharmacology. 17: 407-414. PMID 8642902  0.52
1995 Zlokovic BV. Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1395-1406. PMID 8584471 DOI: 10.1023/A:1016254514167  0.52
1995 Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 37: 955-61. PMID 8559345  0.52
1995 Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. Molecular characterization of a reduced glutathione transporter in the lens. Investigative Ophthalmology & Visual Science. 36: 1785-92. PMID 7635653  0.52
1995 Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Investigative Ophthalmology & Visual Science. 36: 2542-7. PMID 7591644  0.52
1995 Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic Lj. M. Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism European Journal of Ophthalmology. 5: 131-135. PMID 7549442  0.52
1994 Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochemical and Biophysical Research Communications. 201: 402-408. PMID 8198602 DOI: 10.1006/bbrc.1994.1715  0.52
1994 Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochemical and Biophysical Research Communications. 199: 1422-7. PMID 8147886 DOI: 10.1006/bbrc.1994.1389  0.52
1994 Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. Galactose-induced cataract formation in guinea pigs: Morphologic changes and accumulation of galactitol Investigative Ophthalmology and Visual Science. 35: 804-810. PMID 8125742  0.52
1994 Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Experimental Eye Research. 59: 487-496. PMID 7859824 DOI: 10.1006/exer.1994.1134  0.52
1994 Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochemical and Biophysical Research Communications. 205: 1431-7. PMID 7802679 DOI: 10.1006/bbrc.1994.2825  0.52
1993 Zlokovic BV. The blood-brain barrier in vitro: Recent progress Neurochemistry International. 23: 523. PMID 8281120 DOI: 10.1016/0197-0186(93)90099-Q  0.52
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