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Berislav V. Zlokovic - Publications

Affiliations: 
University of Rochester, Rochester, NY 
Area:
Neuroscience Biology, Cell Biology
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Year Citation  Score
2024 Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Molecular Neurodegeneration. 19: 27. PMID 38519970 DOI: 10.1186/s13024-024-00716-w  0.315
2023 Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, ... ... Zlokovic BV, et al. Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nature Neuroscience. PMID 37985802 DOI: 10.1038/s41593-023-01509-y  0.331
2023 Hosoki S, Hansra GK, Jayasena T, Poljak A, Mather KA, Catts VS, Rust R, Sagare A, Kovacic JC, Brodtmann A, Wallin A, Zlokovic BV, Ihara M, Sachdev PS. Molecular biomarkers for vascular cognitive impairment and dementia. Nature Reviews. Neurology. PMID 37957261 DOI: 10.1038/s41582-023-00884-1  0.71
2023 Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Molecular Neurodegeneration. 18: 14. PMID 36829231 DOI: 10.1186/s13024-023-00606-7  0.651
2023 Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Molecular Neurodegeneration. 18: 7. PMID 36707892 DOI: 10.1186/s13024-023-00597-5  0.706
2022 Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, ... ... Zlokovic BV, et al. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36479795 DOI: 10.1002/alz.12845  0.331
2022 Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Molecular Neurodegeneration. 17: 71. PMID 36329501 DOI: 10.1186/s13024-022-00573-5  0.315
2022 Barisano G, Kisler K, Wilkinson B, Nikolakopoulou AM, Sagare AP, Wang Y, Gilliam W, Huuskonen MT, Hung ST, Ichida JK, Gao F, Coba MP, Zlokovic BV. A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice. The Journal of Experimental Medicine. 219. PMID 36040482 DOI: 10.1084/jem.20221137  0.33
2022 Montagne A, Barnes SR, Nation DA, Kisler K, Toga AW, Zlokovic BV. Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions. Geroscience. PMID 35469116 DOI: 10.1007/s11357-022-00571-x  0.374
2022 Barisano G, Montagne A, Kisler K, Schneider JA, Wardlaw JM, Zlokovic BV. Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease. Nature Cardiovascular Research. 1: 108-115. PMID 35450117 DOI: 10.1038/s44161-021-00014-4  0.308
2022 Wang Y, Kisler K, Nikolakopoulou AM, Fernandez JA, Griffin JH, Zlokovic BV. 3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice. Frontiers in Neuroscience. 16: 841916. PMID 35431776 DOI: 10.3389/fnins.2022.841916  0.362
2022 Zhao Q, Dai W, Chen HY, Jacobs RE, Zlokovic BV, Lund BT, Montagne A, Bonnin A. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113310119. PMID 35377817 DOI: 10.1073/pnas.2113310119  0.35
2022 Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, ... ... Zlokovic BV, et al. A single-cell atlas of the normal and malformed human brain vasculature. Science (New York, N.Y.). eabi7377. PMID 35084939 DOI: 10.1126/science.abi7377  0.302
2021 Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, ... Zlokovic BV, et al. accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nature Aging. 1: 506-520. PMID 35291561 DOI: 10.1038/s43587-021-00073-z  0.336
2021 Kisler K, Nikolakopoulou AM, Zlokovic BV. Microglia have a grip on brain microvasculature. Nature Communications. 12: 5290. PMID 34489417 DOI: 10.1038/s41467-021-25595-3  0.32
2021 Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Kisler K, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. The Journal of Experimental Medicine. 218. PMID 33533918 DOI: 10.1084/jem.20202207  0.324
2020 Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, ... ... Zlokovic BV, et al. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12053. PMID 32775596 DOI: 10.1002/Dad2.12053  0.453
2020 Zhao Z, Zlokovic BV. Therapeutic TVs for Crossing Barriers in the Brain. Cell. 182: 267-269. PMID 32707092 DOI: 10.1016/J.Cell.2020.06.041  0.449
2020 Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, et al. Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. Ebiomedicine. 102883. PMID 32690472 DOI: 10.1016/J.Ebiom.2020.102883  0.391
2020 Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun A A AA, et al. Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. Plos One. 15: e0232785. PMID 32469871 DOI: 10.1371/Journal.Pone.0232785  0.302
2020 Kisler K, Huuskonen MT, Zlokovic BV. Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature. Lab Animal. PMID 32424313 DOI: 10.1038/S41684-020-0556-7  0.373
2020 Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain . Frontiers in Aging Neuroscience. 12: 108. PMID 32410982 DOI: 10.3389/Fnagi.2020.00108  0.699
2020 Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, ... ... Zlokovic BV, et al. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 581: 71-76. PMID 32376954 DOI: 10.1038/S41586-020-2247-3  0.693
2020 Sweeney MD, Sagare AP, Pachicano M, Harrington MG, Joe E, Chui HC, Schneider LS, Montagne A, Ringman JM, Fagan AM, Morris JC, Pa J, Nation DA, Toga AW, Zlokovic BV. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32301266 DOI: 10.1002/Alz.12061  0.45
2020 Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Frontiers in Cellular Neuroscience. 14: 27. PMID 32116568 DOI: 10.3389/Fncel.2020.00027  0.466
2020 Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, et al. Perivascular spaces in the brain: anatomy, physiology and pathology. Nature Reviews. Neurology. PMID 32094487 DOI: 10.1038/S41582-020-0312-Z  0.387
2020 Lazic D, Tesic V, Jovanovic M, Brkic M, Milanovic D, Zlokovic BV, Kanazir S, Perovic M. Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease. Neurobiology of Disease. 136: 104745. PMID 31931140 DOI: 10.1016/J.Nbd.2020.104745  0.413
2019 Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J. Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers. Neurobiology of Aging. PMID 31870643 DOI: 10.1016/J.Neurobiolaging.2019.10.013  0.425
2019 Montagne A, Huuskonen MT, Rajagopal G, Sweeney MD, Nation DA, Sepehrband F, D'Orazio LM, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 1568-1575. PMID 31862169 DOI: 10.1016/J.Jalz.2019.07.012  0.431
2019 Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, et al. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. International Journal of Stroke : Official Journal of the International Stroke Society. 1747493019871915. PMID 31543058 DOI: 10.1177/1747493019871915  0.377
2019 Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, et al. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 961-984. PMID 31327392 DOI: 10.1016/J.Jalz.2019.06.001  0.378
2019 Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, ... Zlokovic BV, et al. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nature Neuroscience. 22: 1089-1098. PMID 31235908 DOI: 10.1038/S41593-019-0434-Z  0.389
2019 Jović M, Lončarević-Vasiljković N, Ivković S, Dinić J, Milanović D, Zlokovic B, Kanazir S. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. Plos One. 14: e0216726. PMID 31095617 DOI: 10.1371/Journal.Pone.0216726  0.351
2019 Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Reports. 27: 549-560.e6. PMID 30970257 DOI: 10.1016/J.Celrep.2018.12.055  0.405
2019 Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends in Molecular Medicine. PMID 30661727 DOI: 10.1016/J.Molmed.2019.01.001  0.648
2019 Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. The Journal of Experimental Medicine. PMID 30647119 DOI: 10.1084/Jem.20181035  0.457
2019 Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, ... ... Zlokovic BV, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine. PMID 30643288 DOI: 10.1038/S41591-018-0297-Y  0.716
2019 Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, ... ... Zlokovic BV, et al. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 158-167. PMID 30642436 DOI: 10.1016/J.Jalz.2018.07.222  0.436
2019 Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. Blood-Brain Barrier: From Physiology to Disease and Back. Physiological Reviews. 99: 21-78. PMID 30280653 DOI: 10.1152/Physrev.00050.2017  0.717
2019 Wang Y, Huuskonen MT, Montagne A, Zhao Z, Griffin JH, Zlokovic BV. Abstract WP139: MRI Evaluation and Functional Assessment of Brain Injury Improvement After 3K3A-Activated Protein C Treatment for Murine White Matter Stroke Stroke. 50. DOI: 10.1161/Str.50.Suppl_1.Wp139  0.361
2019 Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV. P4-527: PERICYTE CONTRACTILITY BY OPTOGENETICS REGULATES CAPILLARY DIAMETER AND BLOOD FLOW Alzheimer's & Dementia. 15: P1516-P1516. DOI: 10.1016/J.Jalz.2019.08.074  0.61
2019 Harrington MG, Edminster SP, Buennagel DP, Chiang JP, Sweeney MD, Chui HC, Zlokovic BV, Fonteh AN. P1-165: Four-Year Longitudinal Study Of Cognitively Healthy Individuals: Csf Amyloid/Tau Levels And Nanoparticle Membranes Identify High Risk For Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.720  0.313
2019 Martinez AE, He X, Parekh T, King SM, Sweeney MD, Zlokovic BV, Schneider LS, Harrington MG, Chui HC, Krauss RM, Yassine HN. O3-01-01: Interaction Between Obesity, Brain Hdl, And Apoe4 Genotype In Cerebral Amyloidosis Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4624  0.323
2019 Montagne A, Sweeney MD, Sagare AP, Nation DA, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. P2-385: BRAIN IMAGING OF VASCULAR DYSFUNCTION AS AN EARLY BIOMARKER OF COGNITIVE DECLINE Alzheimer's & Dementia. 15: P751-P751. DOI: 10.1016/J.Jalz.2019.06.2792  0.368
2019 Harrington MG, Siddarth P, Miller KJ, Sweeney MD, Zlokovic BV, Chui HC, Fonteh AN. P2-089: Independent Of Csf Amyloid/Tau Levels, Higher (Normal) Diastolic Blood Pressure In Cognitively Healthy Seniors Associates With Better (Normal) Executive Function And With Lesser (Normal) Memory Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2496  0.318
2019 Albrecht D, Isenberg L, Stradford J, Monreal T, Toga AW, Zlokovic BV, Conti P, Jann K, Pa J. P1-409: Associations Between Cerebral Blood Flow And Amyloid And Tau Pet Binding In Ad-Specific Regions: Findings From 2 Independent Cohorts Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.1014  0.363
2019 Kisler K, Sagare AP, Bazzi S, Lazic D, Hsu C, Lawson EJ, Nelson AR, Zhao Z, Zlokovic BV. UPREGULATION OF ENDOTHELIAL PICALM EXPRESSION USING AN FDA-APPROVED DRUG REDUCES AMYLOID-β LOAD IN THE MURINE BRAIN Alzheimer's & Dementia. 15: P245-P246. DOI: 10.1016/J.Jalz.2019.06.059  0.657
2018 Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, ... ... Zlokovic BV, et al. Final Results of the RHAPSODY trial: A multi-center, Phase 2 trial using a continual reassessment method to determine the safety and tolerability of 3K3A-APC, a Recombinant Variant of Human Activated Protein C, in combination with tissue plasminogen activator, mechanical thrombectomy or both in moderate to severe acute ischemic stroke. Annals of Neurology. PMID 30450637 DOI: 10.1002/Ana.25383  0.303
2018 Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Molecular Neurodegeneration. 13: 57. PMID 30340601 DOI: 10.1186/S13024-018-0286-0  0.489
2018 Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nature Neuroscience. 21: 1318-1331. PMID 30250261 DOI: 10.1038/S41593-018-0234-X  0.487
2018 Sweeney MD, Zlokovic BV. A lymphatic waste-disposal system implicated in Alzheimer's disease. Nature. 560: 172-174. PMID 30076374 DOI: 10.1038/D41586-018-05763-0  0.404
2018 Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C, protease activated receptor 1 and neuroprotection. Blood. PMID 29866816 DOI: 10.1182/Blood-2018-02-769026  0.334
2018 Kisler K, Lazic D, Sweeney MD, Plunkett S, El Khatib M, Vinogradov SA, Boas DA, Sakadži S, Zlokovic BV. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. Nature Protocols. 13: 1377-1402. PMID 29844521 DOI: 10.1038/Nprot.2018.034  0.387
2018 Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM. Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovascular Research. PMID 29726891 DOI: 10.1093/Cvr/Cvy113  0.478
2018 Russin JJ, Montagne A, D'Amore F, He S, Shiroishi MS, Rennert RC, Depetris J, Zlokovic BV, Mack WJ. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18768670. PMID 29611451 DOI: 10.1177/0271678X18768670  0.336
2018 Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, ... ... Zlokovic BV, et al. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature Medicine. PMID 29400714 DOI: 10.1038/Nm.4490  0.619
2018 Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, ... ... Zlokovic BV, et al. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nature Medicine. PMID 29400711 DOI: 10.1038/Nm.4482  0.368
2018 Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nature Reviews. Neurology. 14: 133-150. PMID 29377008 DOI: 10.1038/Nrneurol.2017.188  0.5
2018 Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernandez JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PAR1 Biased Signaling is Required for Activated Protein C In Vivo Benefits in Sepsis and Stroke. Blood. PMID 29343482 DOI: 10.1182/Blood-2017-10-810895  0.32
2018 Zlokovic B. F1-03-04: Alzheimer'S Disease: A Matter Of Blood-Brain Barrier Dysfunction? Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2314  0.439
2017 Liu Q, Radwanski R, Babadjouni R, Patel A, Hodis DM, Baumbacher P, Zhao Z, Zlokovic B, Mack WJ. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17743670. PMID 29192539 DOI: 10.1177/0271678X17743670  0.375
2017 Montagne A, Zhao Z, Zlokovic BV. Alzheimer's disease: A matter of blood-brain barrier dysfunction? The Journal of Experimental Medicine. PMID 29061693 DOI: 10.1084/Jem.20171406  0.523
2017 Netto JP, Iliff J, Stanimirovic D, Krohn KA, Hamilton B, Varallyay C, Gahramanov S, Daldrup-Link H, d'Esterre C, Zlokovic B, Sair H, Lee Y, Taheri S, Jain R, Panigrahy A, et al. Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. Neurosurgery. PMID 28973554 DOI: 10.1093/Neuros/Nyx357  0.385
2017 Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. PMID 28923278 DOI: 10.1016/J.Neuropharm.2017.09.021  0.612
2017 Nelson AR, Sagare AP, Zlokovic BV. Role of clusterin in the brain vascular clearance of amyloid-β. Proceedings of the National Academy of Sciences of the United States of America. PMID 28765369 DOI: 10.1073/Pnas.1711357114  0.73
2017 Zhao Z, Zlokovic BV. Remote control of BBB: A tale of exosomes and microRNA. Cell Research. 27: 849-850. PMID 28674430 DOI: 10.1038/Cr.2017.71  0.356
2017 Kisler K, Nelson AR, Montagne A, Zlokovic BV. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nature Reviews. Neuroscience. PMID 28515434 DOI: 10.1038/Nrn.2017.48  0.711
2017 Ochocinska MJ, Zlokovic BV, Searson PC, Crowder AT, Kraig RP, Ljubimova JY, Mainprize TG, Banks WA, Warren RQ, Kindzelski A, Timmer W, Liu CH. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids and Barriers of the Cns. 14: 12. PMID 28457227 DOI: 10.1186/S12987-017-0061-6  0.443
2017 Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. Plos One. 12: e0176225. PMID 28441414 DOI: 10.1371/Journal.Pone.0176225  0.469
2017 Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžić S, Zlokovic BV. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience. PMID 28135240 DOI: 10.1038/Nn.4489  0.711
2017 Nishida Y, Winkler E, Sagare A, De Vivo D, Zlokovic B. Decreased glucose transporter 1 expression at the blood-brain barrier exacerbates Alzheimer disease-like phenotypes in mouse models Journal of the Neurological Sciences. 381: 768. DOI: 10.1016/J.Jns.2017.08.2167  0.431
2017 Ringman JM, Sweeney MD, Sagare A, Chang Chui H, Zlokovic B. CEREBROSPINAL FLUID MEASURES OF BLOOD BRAIN BARRIER INTEGRITY IN PSEN1-RELATED ALZHEIMER’S DISEASE Alzheimer's & Dementia. 13: P918. DOI: 10.1016/J.Jalz.2017.07.346  0.427
2016 Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27758767 DOI: 10.1161/Atvbaha.116.308038  0.349
2016 Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nature Medicine. PMID 27548576 DOI: 10.1038/Nm.4154  0.362
2016 Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience. 19: 771-83. PMID 27227366 DOI: 10.1038/Nn.4288  0.43
2016 Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thrombosis Research. 141: S62-S64. PMID 27207428 DOI: 10.1016/S0049-3848(16)30368-1  0.371
2016 Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathologica. PMID 27038189 DOI: 10.1007/S00401-016-1570-0  0.469
2016 Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, et al. Clearance systems in the brain-implications for Alzheimer diseaser. Nature Reviews. Neurology. 12: 248. PMID 27020556 DOI: 10.1038/Nrneurol.2016.36  0.359
2016 Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Frontiers in Neuroscience. 10: 46. PMID 26941593 DOI: 10.3389/Fnins.2016.00046  0.308
2016 Sinha RK, Wang Y, Zhao Z, Fernandez JA, Gupta N, Xu X, Martin G, Kupriyanov S, Mosnier LO, Zlokovic B, Griffin JH. Novel R41Q- and R46Q-PAR1-Modified Mice Enable Proof-of-Concept Studies for In Vivo Protective Mechanisms of Action for Activated Protein C (APC) in Sepsis and Stroke Blood. 128: 13-13. DOI: 10.1182/Blood.V128.22.13.13  0.341
2016 Zlokovic B. FTS3-02-03: Interactions of Vascular and Alzheimer Disease Alzheimer's & Dementia. 12: P278-P278. DOI: 10.1016/J.Jalz.2016.06.2390  0.33
2016 Schneider JA, Wilcock DM, Iadecola C, Skoog I, Kalaria RN, Zlokovic B, Snyder HM, Carrillo MC, Amouyel P. FTS3-01-01: Biological Underpinnings of Vascular Contributions to Dementia Alzheimer's & Dementia. 12: P276-P276. DOI: 10.1016/J.Jalz.2016.06.2383  0.309
2015 Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochimica Et Biophysica Acta. PMID 26705676 DOI: 10.1016/J.Bbadis.2015.12.016  0.695
2015 Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 163: 1064-78. PMID 26590417 DOI: 10.1016/J.Cell.2015.10.067  0.71
2015 Montagne A, Toga AW, Zlokovic BV. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. Jama Neurology. 1-2. PMID 26524294 DOI: 10.1001/Jamaneurol.2015.2960  0.416
2015 Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neuroscience Letters. 607: 97-101. PMID 26407747 DOI: 10.1016/J.Neulet.2015.09.025  0.468
2015 Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Frontiers in Aging Neuroscience. 7: 136. PMID 26236233 DOI: 10.3389/Fnagi.2015.00136  0.724
2015 Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, et al. Consensus statement for diagnosis of subcortical small vessel disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26198175 DOI: 10.1038/Jcbfm.2015.172  0.353
2015 Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, et al. Clearance systems in the brain-implications for Alzheimer disease. Nature Reviews. Neurology. PMID 26195256 DOI: 10.1038/Nrneurol.2015.119  0.465
2015 Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magnetic Resonance in Medicine. PMID 26077645 DOI: 10.1002/Mrm.25793  0.371
2015 Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, ... ... Zlokovic BV, et al. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nature Neuroscience. 18: 978-87. PMID 26005850 DOI: 10.1038/Nn.4025  0.511
2015 Sweeney MD, Sagare AP, Zlokovic BV. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 1055-68. PMID 25899298 DOI: 10.1038/Jcbfm.2015.76  0.397
2015 Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 125: 2898-907. PMID 25824691 DOI: 10.1182/Blood-2015-02-355974  0.364
2015 Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 25757756 DOI: 10.1038/Jcbfm.2015.44  0.461
2015 Montagne A, Pa J, Zlokovic BV. Vascular plasticity and cognition during normal aging and dementia. Jama Neurology. 72: 495-6. PMID 25751405 DOI: 10.1001/Jamaneurol.2014.4636  0.436
2015 Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wenby RB, Soto J, ... ... Zlokovic BV, et al. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience. 18: 521-30. PMID 25730668 DOI: 10.1038/Nn.3966  0.706
2015 Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 85: 296-302. PMID 25611508 DOI: 10.1016/J.Neuron.2014.12.032  0.487
2015 Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, et al. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 710-717. PMID 25510382 DOI: 10.1016/J.Jalz.2014.10.008  0.368
2015 Zlokovic B. S1-01-02: Blood-brain barrier mechanisms of neurodegeneration in Alzheimer's disease Alzheimer's & Dementia. 11: P114-P114. DOI: 10.1016/J.Jalz.2015.07.003  0.458
2014 Mosnier LO, Zlokovic BV, Griffin JH. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thrombosis and Haemostasis. 112: 883-92. PMID 25230930 DOI: 10.1160/Th14-05-0448  0.302
2014 Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, ... ... Zlokovic BV, et al. Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 83: 851-60. PMID 25080517 DOI: 10.1212/Wnl.0000000000000733  0.33
2014 Winkler EA, Sagare AP, Zlokovic BV. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathology (Zurich, Switzerland). 24: 371-86. PMID 24946075 DOI: 10.1111/Bpa.12152  0.48
2014 Zhao Z, Zlokovic BV. Blood-brain barrier: a dual life of MFSD2A? Neuron. 82: 728-30. PMID 24853933 DOI: 10.1016/J.Neuron.2014.05.012  0.368
2014 Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proceedings of the National Academy of Sciences of the United States of America. 111: E1035-42. PMID 24591593 DOI: 10.1073/Pnas.1401595111  0.33
2014 Zhao Z, Zlokovic BV. CorrectionBlood-Brain Barrier: A Dual Life of MFSD2A? Neuron. DOI: 10.1016/J.Neuron.2014.05.034  0.391
2014 Zlokovic BV. FTS-02-03: BLOOD-BRAIN BARRIER DAMAGE, NEURONAL DYSFUNCTION, AND DEGENERATION Alzheimer's & Dementia. 10: P285-P285. DOI: 10.1016/J.Jalz.2014.04.472  0.434
2013 Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nature Communications. 4: 2932. PMID 24336108 DOI: 10.1038/Ncomms3932  0.458
2013 Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. Journal of Thrombosis and Haemostasis : Jth. 11: 2059-62. PMID 24034518 DOI: 10.1111/Jth.12400  0.317
2013 Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. Jama Neurology. 70: 1198-200. PMID 24030206 DOI: 10.1001/Jamaneurol.2013.3841  0.454
2013 Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. The Journal of Biological Chemistry. 288: 15154-66. PMID 23580652 DOI: 10.1074/Jbc.M112.439570  0.426
2013 Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6181-90. PMID 23554499 DOI: 10.1523/Jneurosci.4491-12.2013  0.343
2013 Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells, Molecules & Diseases. 51: 104-8. PMID 23541526 DOI: 10.1016/J.Bcmd.2013.02.009  0.32
2013 Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Research. 1507: 97-104. PMID 23438513 DOI: 10.1016/J.Brainres.2013.02.023  0.351
2013 Zlokovic BV. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. Jama Neurology. 70: 440-4. PMID 23400708 DOI: 10.1001/Jamaneurol.2013.2152  0.527
2013 Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathology (Zurich, Switzerland). 23: 303-10. PMID 23126372 DOI: 10.1111/Bpa.12004  0.479
2013 Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathologica. 125: 111-20. PMID 22941226 DOI: 10.1007/S00401-012-1039-8  0.323
2013 Sagare AP, Bell RD, Zlokovic BV. Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: S87-100. PMID 22751174 DOI: 10.3233/Jad-2012-129037  0.508
2012 Sagare AP, Bell RD, Zlokovic BV. Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23028132 DOI: 10.1101/Cshperspect.A011452  0.501
2012 Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 109: 15502-7. PMID 22927427 DOI: 10.1073/Pnas.1206446109  0.501
2012 Sagare AP, Deane R, Zlokovic BV. Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacology & Therapeutics. 136: 94-105. PMID 22820095 DOI: 10.1016/J.Pharmthera.2012.07.008  0.479
2012 Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Current Pharmaceutical Design. 18: 4215-22. PMID 22632606 DOI: 10.2174/138161212802430413  0.305
2012 Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 485: 512-6. PMID 22622580 DOI: 10.1038/Nature11087  0.465
2012 Carnevale D, Mascio G, D'Andrea I, Fardella V, Bell RD, Branchi I, Pallante F, Zlokovic B, Yan SS, Lembo G. Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension (Dallas, Tex. : 1979). 60: 188-97. PMID 22615109 DOI: 10.1161/Hypertensionaha.112.195511  0.503
2012 Griffin JH, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. International Journal of Hematology. 95: 333-45. PMID 22477541 DOI: 10.1007/S12185-012-1059-0  0.311
2012 Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, ... Zlokovic BV, et al. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 122: 1377-92. PMID 22406537 DOI: 10.1172/Jci58642  0.523
2011 Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nature Reviews. Neuroscience. 12: 723-38. PMID 22048062 DOI: 10.1038/Nrn3114  0.488
2011 Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nature Neuroscience. 14: 1398-405. PMID 22030551 DOI: 10.1038/Nn.2946  0.46
2011 Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. Journal of Neuroscience Research. 89: 967-8. PMID 21544850 DOI: 10.1002/Jnr.22670  0.45
2011 Winkler EA, Bell RD, Zlokovic BV. Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Developmental Cell. 20: 279-80. PMID 21397835 DOI: 10.1016/J.Devcel.2011.03.002  0.349
2011 Zlokovic BV, Griffin JH. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends in Neurosciences. 34: 198-209. PMID 21353711 DOI: 10.1016/J.Tins.2011.01.005  0.394
2011 Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Molecular Neurodegeneration. 6: 13. PMID 21291561 DOI: 10.1186/1750-1326-6-13  0.304
2011 Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 25-34. PMID 21157031 DOI: 10.3233/Jad-2010-101248  0.365
2011 Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. Methamphetamine causes sustained depression in cerebral blood flow. Brain Research. 1373: 91-100. PMID 21156163 DOI: 10.1016/J.Brainres.2010.12.017  0.359
2010 Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15521-34. PMID 21084607 DOI: 10.1523/Jneurosci.4437-10.2010  0.318
2010 Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 68: 409-27. PMID 21040844 DOI: 10.1016/J.Neuron.2010.09.043  0.487
2010 Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. Journal of Neurochemistry. 115: 1077-89. PMID 20854368 DOI: 10.1111/J.1471-4159.2010.07002.X  0.493
2010 Winkler EA, Bell RD, Zlokovic BV. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Molecular Neurodegeneration. 5: 32. PMID 20738866 DOI: 10.1186/1750-1326-5-32  0.387
2010 Walker CT, Marky AH, Petraglia AL, Ali T, Chow N, Zlokovic BV. Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Research. 1347: 125-31. PMID 20513369 DOI: 10.1227/01.Neu.0000387010.07071.B6  0.35
2010 Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 115: 4963-72. PMID 20348395 DOI: 10.1182/Blood-2010-01-262386  0.457
2010 Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Research. 1317: 218-26. PMID 20043896 DOI: 10.1016/J.Brainres.2009.11.084  0.425
2010 Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 66: 165-71; discussion 1. PMID 20023547 DOI: 10.1227/01.Neu.0000363148.49779.68  0.399
2010 Zlokovic BV. Blood-Brain Barrier and Neurovascular Mechanisms of Neurodegeneration and Injury Encyclopedia of Neuroscience. 265-271. DOI: 10.1016/B978-008045046-9.00491-5  0.364
2009 Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, ... ... Zlokovic BV, et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. The Journal of Clinical Investigation. 119: 3437-49. PMID 19841542 DOI: 10.1172/Jci38476  0.353
2009 Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathologica. 118: 103-13. PMID 19319544 DOI: 10.1007/S00401-009-0522-3  0.528
2009 Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. The European Journal of Neuroscience. 29: 1119-30. PMID 19302148 DOI: 10.1111/J.1460-9568.2009.06664.X  0.367
2009 Deane R, Bell RD, Sagare A, Zlokovic BV. Clearance of amyloid-β peptide across the blood-brain barrier: Implication for therapies in Alzheimer's disease Cns and Neurological Disorders - Drug Targets. 8: 16-30. PMID 19275634 DOI: 10.2174/187152709787601867  0.494
2009 Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. Journal of Neurochemistry. 109: 116-24. PMID 19166505 DOI: 10.1111/J.1471-4159.2009.05921.X  0.337
2009 Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology. 11: 143-53. PMID 19098903 DOI: 10.1038/Ncb1819  0.425
2009 Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV. Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke; a Journal of Cerebral Circulation. 40: 1864-9. PMID 19057019 DOI: 10.1161/Strokeaha.108.536680  0.395
2009 Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 25-33. PMID 18841163 DOI: 10.1038/Jcbfm.2008.117  0.461
2008 Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12788-97. PMID 19036971 DOI: 10.1523/Jneurosci.3485-08.2008  0.46
2008 Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. The Journal of Clinical Investigation. 118: 4002-13. PMID 19033669 DOI: 10.1172/Jci36663  0.449
2008 Dearie R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Aβ clearance in Alzheimer's disease Current Pharmaceutical Design. 14: 1601-1605. PMID 18673201 DOI: 10.2174/138161208784705487  0.466
2008 Zlokovic BV. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 5: 409-14. PMID 18625452 DOI: 10.1016/J.Nurt.2008.05.011  0.467
2008 Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience. 11: 420-2. PMID 18344992 DOI: 10.1038/Nn2073  0.335
2008 Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57: 178-201. PMID 18215617 DOI: 10.1016/J.Neuron.2008.01.003  0.486
2008 Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 764-71. PMID 17971789 DOI: 10.1038/Sj.Jcbfm.9600573  0.32
2008 Zlokovic BV. S4-02-05: Blood-brain barrier mechanisms in Alzheimer's disease: Roles of rage and LRP Alzheimer's & Dementia. 4: T179-T179. DOI: 10.1016/J.Jalz.2008.05.483  0.46
2007 Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, ... Zlokovic BV, et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine. 13: 1029-31. PMID 17694066 DOI: 10.1038/Nm1635  0.408
2007 Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Current Alzheimer Research. 4: 191-7. PMID 17430246 DOI: 10.2174/156720507780362245  0.523
2007 Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Annals of the New York Academy of Sciences. 1097: 40-50. PMID 17413008 DOI: 10.1196/Annals.1379.004  0.389
2007 Thiyagarajan M, Cheng T, Zlokovic BV. Endothelial cell protein C receptor: role beyond endothelium? Circulation Research. 100: 155-7. PMID 17272817 DOI: 10.1161/01.Res.0000258167.48227.84  0.307
2007 Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proceedings of the National Academy of Sciences of the United States of America. 104: 823-8. PMID 17215356 DOI: 10.1073/Pnas.0608251104  0.436
2007 Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 109: 3161-72. PMID 17110453 DOI: 10.1182/Blood-2006-09-003004  0.336
2007 Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 909-18. PMID 17077814 DOI: 10.1038/Sj.Jcbfm.9600419  0.429
2006 Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine. 12: 1278-85. PMID 17072311 DOI: 10.1038/Nm1498  0.408
2006 Contreras JA, Sweeney MD, Sagare A, Morris JC, Fagan AM, Benzinger TL, Zlokovic B, Toga AW, Pa J. IC-P-030: CSF SPDGFRB, A MEASURE OF VASCULAR DYSFUNCTION, IS RELATED TO DISRUPTED FUNCTIONAL CONNECTIVITY AMONG BRAIN REGIONS ASSOCIATED WITH ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P34-P35. DOI: 10.1016/J.Jalz.2018.06.2094  0.412
2006 Ringman JM, Sweeney MD, Zlokovic B, Chui HC. P3-276: PYRAMIDAL SIGNS IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1183-P1183. DOI: 10.1016/J.Jalz.2018.06.1636  0.301
2005 Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11495-503. PMID 16354907 DOI: 10.1523/Jneurosci.3697-05.2005  0.422
2005 Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 115: 3285-90. PMID 16239972 DOI: 10.1172/Jci25247  0.462
2005 Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. Functional recovery after embolic stroke in rodents by activated protein C. Annals of Neurology. 58: 474-7. PMID 16130108 DOI: 10.1002/Ana.20602  0.335
2005 Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, ... ... Zlokovic BV, et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine. 11: 959-65. PMID 16116430 DOI: 10.1038/Nm1287  0.499
2005 Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends in Neurosciences. 28: 202-8. PMID 15808355 DOI: 10.1016/J.Tins.2005.02.001  0.454
2005 Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain Pathology (Zurich, Switzerland). 15: 78-83. PMID 15779240 DOI: 10.1111/J.1750-3639.2005.Tb00103.X  0.453
2005 Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. American Journal of Physiology. Cell Physiology. 289: C264-76. PMID 15743889 DOI: 10.1152/Ajpcell.00461.2004  0.389
2004 Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine. 10: 1379-83. PMID 15516929 DOI: 10.1038/Nm1122  0.353
2004 Deane R, Wu Z, Zlokovic BV. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke; a Journal of Cerebral Circulation. 35: 2628-31. PMID 15459432 DOI: 10.1161/01.Str.0000143452.85382.D1  0.472
2004 LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. Journal of Neuroscience Methods. 138: 233-42. PMID 15325132 DOI: 10.1016/J.Jneumeth.2004.04.026  0.488
2004 Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, ... Zlokovic BV, et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 43: 333-44. PMID 15294142 DOI: 10.1016/J.Neuron.2004.07.017  0.414
2004 Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 25: 605-16. PMID 15183014 DOI: 10.1016/J.Neuro.2003.08.007  0.402
2004 Zlokovic BV. Clearing amyloid through the blood-brain barrier Journal of Neurochemistry. 89: 807-811. PMID 15140180 DOI: 10.1111/J.1471-4159.2004.02385.X  0.504
2004 Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. The Journal of Biological Chemistry. 279: 20296-306. PMID 14985348 DOI: 10.1074/Jbc.M312946200  0.409
2004 Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain Journal of Neurochemistry. 88: 813-820. PMID 14756801 DOI: 10.1046/J.1471-4159.2003.02221.X  0.376
2004 Deane R, Hamm K, Sagare A, Zlokovic BV. P4-412 FC and non-FC dependent blood-brain barrier (BBB) clearance from brain to blood of anti-Aβ antibody in mice Neurobiology of Aging. 25: S591. DOI: 10.1016/S0197-4580(04)81968-7  0.454
2004 Miano J, Paxia A, Li F, Ibrahim J, Zidovetzki R, Brooks A, Zlokovic B. P3-326 Dysregulation in serum response factor and myocardin in Alzheimer's cerebral arterial system Neurobiology of Aging. 25: S447-S448. DOI: 10.1016/S0197-4580(04)81476-3  0.304
2004 Zlokovic BV, Wu Z, Deane R, Davis J, Yan SD, Hu HW, VanHostrand W, Hamm K, Sagare A, Parisi M. O2-03-03 Inefficient LRP-mediated Aβ clearance at the blood-brain barrier contributes to neurotoxic and vasculotropic Aβ brain accumulations Neurobiology of Aging. 25: S36-S37. DOI: 10.1016/S0197-4580(04)80121-0  0.479
2004 Wu Z, Zlokovic BV. O1-03-05 APOE isoform-specific inhibition of angiogenic transduction signaling pathways in human brain endothelium is regulated via LRP and megalin Neurobiology of Aging. 25: S15. DOI: 10.1016/S0197-4580(04)80048-4  0.352
2003 Wu Z, Hofman FM, Zlokovic BV. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. Journal of Neuroscience Methods. 130: 53-63. PMID 14583404 DOI: 10.1016/S0165-0270(03)00206-1  0.464
2003 Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, ... ... Zlokovic B, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine. 9: 907-13. PMID 12808450 DOI: 10.1038/Nm890  0.462
2003 Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells, Molecules & Diseases. 30: 271-6. PMID 12737945 DOI: 10.1016/S1079-9796(03)00034-2  0.331
2003 Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 107: 1791-6. PMID 12665496 DOI: 10.1161/01.Cir.0000058460.34453.5A  0.356
2003 Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 101: 4797-801. PMID 12586611 DOI: 10.1182/Blood-2002-12-3680  0.315
2003 Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nature Medicine. 9: 338-42. PMID 12563316 DOI: 10.1038/Nm826  0.415
2003 Amar AP, Zlokovic BV, Apuzzo MLJ, Neuwelt EA, Piepmeier JM, Grossman RG, Bendok BR, Hopkins LN. Endovascular restorative neurosurgery: A novel concept for molecular and cellular therapy of the nervous system Neurosurgery. 52: 402-413. PMID 12535371 DOI: 10.1227/01.Neu.0000043698.86548.A0  0.378
2002 Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascular Pharmacology. 38: 303-13. PMID 12529925 DOI: 10.1016/S1537-1891(02)00198-2  0.354
2002 Zlokovic BV. Vascular disorder in Alzheimer's disease: Role in pathogenesis of dementia and therapeutic targets Advanced Drug Delivery Reviews. 54: 1553-1559. PMID 12453672 DOI: 10.1016/S0169-409X(02)00150-3  0.494
2002 Grammas P, Yamada M, Zlokovic B. The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 4: 217-23. PMID 12226540 DOI: 10.3233/Jad-2002-4311  0.429
2002 Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. American Journal of Physiology. Cell Physiology. 283: C895-904. PMID 12176746 DOI: 10.1152/Ajpcell.00293.2001  0.462
2002 Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. Journal of Drug Targeting. 10: 359-68. PMID 12164385 DOI: 10.1080/10611860290031831  0.463
2002 Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiology of Aging. 23: 405-12. PMID 11959403 DOI: 10.1016/S0197-4580(01)00317-7  0.452
2001 Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures Journal of Neuroimmunology. 116: 62-73. PMID 11311331 DOI: 10.1016/S0165-5728(01)00280-6  0.4
2001 Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke Circulation. 103: 1799-1805. PMID 11282913 DOI: 10.1161/01.Cir.103.13.1799  0.307
2001 MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. Preferential susceptibility of brain tumors to the antiangiogenic effects of an αv integrin antagonist Neurosurgery. 48: 151-157. PMID 11152340 DOI: 10.1097/00006123-200101000-00026  0.343
2000 Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. The Journal of Clinical Investigation. 106: 1489-99. PMID 11120756 DOI: 10.1172/Jci10498  0.483
2000 Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. American Journal of Physiology. Cell Physiology. 279: C1772-81. PMID 11078691 DOI: 10.1152/Ajpcell.2000.279.6.C1772  0.456
2000 Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microscopy Research and Technique. 50: 305-15. PMID 10936885 DOI: 10.1002/1097-0029(20000815)50:4<305::Aid-Jemt10>3.0.Co;2-L  0.423
2000 Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochimica Et Biophysica Acta. 1502: 145-57. PMID 10899440 DOI: 10.1016/S0925-4439(00)00041-7  0.38
2000 Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model Journal of Cerebral Blood Flow and Metabolism. 20: 998-1009. PMID 10894183 DOI: 10.1097/00004647-200006000-00012  0.415
2000 Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nature Medicine. 6: 718. PMID 10888893 DOI: 10.1038/77397  0.406
2000 Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. The Biochemical Journal. 348: 359-65. PMID 10816430 DOI: 10.1042/0264-6021:3480359  0.342
2000 Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier Endocrinology. 141: 1434-1441. PMID 10746647 DOI: 10.1210/Endo.141.4.7435  0.42
1999 Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2801-6. PMID 10559029 DOI: 10.1161/01.Atv.19.11.2801  0.382
1999 Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo MLJ, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells Neurosurgery. 45: 962-970. PMID 10515502 DOI: 10.1097/00006123-199910000-00072  0.339
1999 Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions Neuroscience Letters. 272: 127-130. PMID 10507558 DOI: 10.1016/S0304-3940(99)00592-3  0.375
1999 Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharmaceutical Research. 16: 1360-5. PMID 10496650 DOI: 10.1023/A:1018938722768  0.407
1999 Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Experimental Neurology. 157: 194-201. PMID 10222122 DOI: 10.1006/Exnr.1999.7052  0.389
1999 Zlokovic B. Vascular Endothelial Growth Factor Expression, Vascular Volume, and Capillary Permeability in Human Brain Tumors Neurosurgery. 44: 740-740. DOI: 10.1097/00006123-199904000-00023  0.357
1999 Zlokovic BV. Treatment of Brain Edema with a Nonpeptide Arginine Vasopressin V1 Receptor Antagonist OPC-21268 in Rats Neurosurgery. 44: 154-155. DOI: 10.1097/00006123-199901000-00093  0.332
1998 Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat brain capillary thrombomodulin: Structure and function Thrombosis Research. 92: 213-219. PMID 9851812 DOI: 10.1016/S0049-3848(98)00135-2  0.414
1998 MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein Neurosurgery. 43: 1437-1443. PMID 9848858 DOI: 10.1097/00006123-199812000-00101  0.344
1998 Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain Neurosurgery. 43: 909-913. PMID 9766319 DOI: 10.1097/00006123-199810000-00107  0.41
1998 Zlokovic BV, Apuzzo MLJ. Strategies to circumvent vascular barriers of the central nervous system Neurosurgery. 43: 877-878. PMID 9766315 DOI: 10.1097/00006123-199810000-00089  0.32
1998 Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thrombosis Research. 91: 191-7. PMID 9736422 DOI: 10.1016/S0049-3848(98)00085-1  0.312
1998 Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. The Journal of Clinical Investigation. 102: 734-43. PMID 9710442 DOI: 10.1172/Jci2029  0.44
1998 LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Human Gene Therapy. 9: 989-95. PMID 9607410 DOI: 10.1089/Hum.1998.9.7-989  0.304
1998 Lavine SD, Hofman FM, Zlokovic BV. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury Journal of Cerebral Blood Flow and Metabolism. 18: 52-58. PMID 9428305 DOI: 10.1097/00004647-199801000-00005  0.315
1998 Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. Journal of Neurochemistry. 70: 210-5. PMID 9422364 DOI: 10.1046/J.1471-4159.1998.70010210.X  0.382
1998 Zlokovic BV. Reactive Oxygen Species in Reoxygenation Injury of Rat Brain Capillary Endothelial Cells Neurosurgery. 43: 584-584. DOI: 10.1097/00006123-199809000-00101  0.338
1998 Zlokovic B. Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means Neurosurgery. 42: 1099-1100. DOI: 10.1097/00006123-199805000-00086  0.452
1998 Zlokovic BV. Neural Stem and Progenitor Cells: A Strategy for Gene Therapy and Brain Repair Neurosurgery. 42: 868-868. DOI: 10.1097/00006123-199804000-00105  0.308
1997 Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. Thrombomodulin expression in bovine brain capillaries: Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3139-3146. PMID 9409303 DOI: 10.1161/01.Atv.17.11.3139  0.466
1997 Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model Journal of Neurosurgery. 87: 731-737. PMID 9347982 DOI: 10.3171/Jns.1997.87.5.0731  0.367
1997 Zlokovic B. Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology. Neurobiology of Disease. 4: 23-6. PMID 9258908 DOI: 10.1006/Nbdi.1997.0134  0.49
1997 Zlokovic BV, Apuzzo MLJ. Cellular and molecular neurosurgery: Pathways from concept to reality - Part II: Vector systems and delivery methodologies for gene therapy of the central nervous system Neurosurgery. 40: 805-813. PMID 9092854 DOI: 10.1097/00006123-199704000-00028  0.407
1997 Zlokovic BV, Apuzzo MLJ. Cellular and molecular neurosurgery: Pathways from concept to reality - Part I: Target disorders and concept approaches to gene therapy of the central nervous system Neurosurgery. 40: 789-804. PMID 9092853 DOI: 10.1097/00006123-199704000-00027  0.301
1997 Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats Journal of Cerebral Blood Flow and Metabolism. 17: 136-146. PMID 9040492 DOI: 10.1097/00004647-199702000-00002  0.363
1997 Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. Neuroprotective effects of nicardipine in a rat model of ischemia and reperfusion Neurosurgical Focus. 2: E4. DOI: 10.3171/Foc.1997.2.6.5  0.372
1997 Lavine S, Kittaka M, Hofman F, Weiss M, Zlokovic B. Anti-TNF-alpha Antibody Reverses Experimental and Endotoxin Augmented Focal Ischemic Brain Injury Neurosurgery. 41: 742-742. DOI: 10.1097/00006123-199709000-00143  0.311
1997 Martel CL, Ghiso J, Frangione B, Zlokovic BV. Transport of apolipoproteins E and J at the blood-brain barrier: Relevance to Alzheimer's disease S.T.P. Pharma Sciences. 7: 28-36.  0.341
1996 Zlokovic BV. Cerebrovascular transport of Alzheimer's amyloid β and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier Life Sciences. 59: 1483-1497. PMID 8890929 DOI: 10.1016/0024-3205(96)00310-4  0.493
1996 Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. Cellular uptake and transport of methylprednisolone at the blood-brain barrier Neurosurgery. 38: 348-354. PMID 8869063 DOI: 10.1097/00006123-199602000-00023  0.345
1996 Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid β in guinea pigs Neuroscience Letters. 206: 157-160. PMID 8710175 DOI: 10.1016/S0304-3940(96)12462-9  0.449
1996 Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences of the United States of America. 93: 4229-34. PMID 8633046 DOI: 10.1073/Pnas.93.9.4229  0.408
1996 Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. The Journal of Biological Chemistry. 271: 9754-8. PMID 8621654 DOI: 10.1074/Jbc.271.16.9754  0.343
1996 Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke; a Journal of Cerebral Circulation. 27: 712-9. PMID 8614937 DOI: 10.1161/01.Str.27.4.712  0.373
1996 Zlokovic B, Martel C, McComb J, Frangione B, Ghiso J. 583 Anti-amyloidogenic functions of the blood-brain barrier: Role of Gp330/megalin, and exclusion of apolipoproteins E3 and E4 Neurobiology of Aging. 17: S145. DOI: 10.1016/S0197-4580(96)80585-9  0.366
1996 Ghiso J, Martel C, Mackic J, Gordon J, Comb M, Frangione B, Zlokovic B. 582 In vivo blood-brain barrier uptake of Alzheimer's Aβ peptides in guinea pigs: Evidence for vascular sequestration of Aβ1-40 (but not Aβ1-42) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80584-7  0.467
1995 Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism Methods and Findings in Experimental and Clinical Pharmacology. 17: 407-414. PMID 8642902  0.351
1995 Zlokovic BV. Cerebrovascular Permeability to Peptides: Manipulations of Transport Systems at the Blood-Brain Barrier Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1395-1406. PMID 8584471 DOI: 10.1023/A:1016254514167  0.322
1995 Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 37: 955-61. PMID 8559345 DOI: 10.1227/00006123-199511000-00015  0.485
1995 Zlokovic B. The blood-brain barrier: Cellular and molecular biology Neurochemistry International. 26: 99. DOI: 10.1016/0197-0186(95)90004-7  0.439
1994 Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain Biochemical and Biophysical Research Communications. 201: 402-408. PMID 8198602 DOI: 10.1006/Bbrc.1994.1715  0.453
1994 Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochemical and Biophysical Research Communications. 199: 1422-7. PMID 8147886 DOI: 10.1006/Bbrc.1994.1389  0.347
1994 Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochemical and Biophysical Research Communications. 205: 1431-7. PMID 7802679 DOI: 10.1006/Bbrc.1994.2825  0.381
1993 Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. Expression of Na,K-ATPase at the blood-brain interface. Advances in Experimental Medicine and Biology. 331: 55-60. PMID 8392783 DOI: 10.1007/978-1-4615-2920-0_9  0.398
1993 Zlokovic BV, Mackic JB, Lipovac MN, McComb JG, Weiss MH. Blood-brain transport of vasopressin. Advances in Experimental Medicine and Biology. 331: 143-7. PMID 8333329 DOI: 10.1007/978-1-4615-2920-0_23  0.433
1993 Zlokovic BV. The blood-brain barrier in vitro: Recent progress Neurochemistry International. 23: 523. PMID 8281120 DOI: 10.1016/0197-0186(93)90099-Q  0.466
1993 Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochemical and Biophysical Research Communications. 197: 1034-40. PMID 8280117 DOI: 10.1006/Bbrc.1993.2582  0.493
1992 Zlokovic BV, Banks WA, el Kadi H, Erchegyi J, Mackic JB, McComb JG, Kastin AJ. Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Research. 590: 213-8. PMID 1422832 DOI: 10.1016/0006-8993(92)91098-Y  0.438
1990 Begley DJ, Squires LK, Zloković BV, Mitrović DM, Hughes CC, Revest PA, Greenwood J. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. Journal of Neurochemistry. 55: 1222-30. PMID 2398356 DOI: 10.1111/J.1471-4159.1990.Tb03128.X  0.445
1990 Zlokovic BV, Skundric DS, Segal MB, Lipovac MN, Mackic JB, Davson H. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Experimental Neurology. 107: 263-70. PMID 1689666 DOI: 10.1016/0014-4886(90)90144-H  0.445
1990 Zlokovic BV. In vivo approaches for studying peptide interactions at the blood — brain barrier Journal of Controlled Release. 13: 185-201. DOI: 10.1016/0168-3659(90)90009-I  0.434
1989 Zlokovic BV, Mackic JB, Djuricic B, Davson H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. Journal of Neurochemistry. 53: 1333-40. PMID 2795003 DOI: 10.1111/J.1471-4159.1989.Tb08522.X  0.435
1989 Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 10: 249-54. PMID 2547200 DOI: 10.1016/0196-9781(89)90026-0  0.443
1989 Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic DM. Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain. Journal of the Neurological Sciences. 94: 41-50. PMID 2515257 DOI: 10.1016/0022-510X(89)90216-5  0.412
1989 Rakic LM, Zlokovic BV, Segal MB, Lipovac MH, Mitrovic DM, Veskov R, Mackic JB, Davson H. Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs. Metabolic Brain Disease. 4: 9-15. PMID 2495423 DOI: 10.1007/Bf00999488  0.382
1989 Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H. Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metabolic Brain Disease. 4: 33-40. PMID 2495422 DOI: 10.1007/Bf00999491  0.468
1988 Zlokovic BV, Segal MB, Davson H, Jankov RM. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 9: 533-8. PMID 3420012 DOI: 10.1016/0196-9781(88)90160-X  0.339
1988 Zlokovic BV, Segal MB, Davson H, Mitrovic DM. Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regulatory Peptides. 20: 33-44. PMID 3127863 DOI: 10.1016/0167-0115(88)90055-9  0.309
1986 Zloković BV, Begley DJ, Djuricić BM, Mitrovic DM. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. Journal of Neurochemistry. 46: 1444-51. PMID 3083044 DOI: 10.1111/J.1471-4159.1986.Tb01760.X  0.419
1985 Zlokovic BV, Begley DJ, Chain-Eliash DG. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Research. 336: 125-32. PMID 3891014 DOI: 10.1016/0006-8993(85)90423-8  0.386
Low-probability matches (unlikely to be authored by this person)
2020 Mukherjee P, Lyden P, Fernández JA, Davis TP, Pryor KE, Zlokovic BV, Griffin JH. 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase. Stroke. 51: 2236-2239. PMID 32568648 DOI: 10.1161/Strokeaha.120.028793  0.298
2012 Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke; a Journal of Cerebral Circulation. 43: 2444-9. PMID 22811462 DOI: 10.1161/Strokeaha.112.658997  0.298
2002 Griffin JH, Zlokovic B, Fernández JA. Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke Seminars in Hematology. 39: 197-205. PMID 12124682 DOI: 10.1053/Shem.2002.34093  0.298
2015 Amar AP, Griffin JH, Zlokovic BV. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Frontiers in Cellular Neuroscience. 9: 344. PMID 26388732 DOI: 10.3389/Fncel.2015.00344  0.297
2016 Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. PMID 27524440 DOI: 10.1016/J.Stem.2016.07.019  0.297
1993 Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 34: 211-9. PMID 8384107 DOI: 10.1111/J.1528-1157.1993.Tb02401.X  0.296
2020 Montagne A, Nation DA, Zlokovic BV. Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. STROKEAHA119028814. PMID 32070225 DOI: 10.1161/Strokeaha.119.028814  0.295
1997 Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharmaceutical Research. 14: 80-5. PMID 9034225 DOI: 10.1023/A:1012011618785  0.295
2014 Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nature Communications. 5: 4820. PMID 25190485 DOI: 10.1038/Ncomms5820  0.292
2013 Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke; a Journal of Cerebral Circulation. 44: 3529-36. PMID 24159062 DOI: 10.1161/Strokeaha.113.003350  0.29
2022 Wiggers A, Ashina H, Hadjikhani N, Sagare A, Zlokovic BV, Lauritzen M, Ashina M. Brain barriers and their potential role in migraine pathophysiology. The Journal of Headache and Pain. 23: 16. PMID 35081902 DOI: 10.1186/s10194-021-01365-w  0.29
2018 Wang Y, Zhao Z, Montagne A, Griffin JH, Zlokovic B. Abstract WP90: Activate Protein C Analog Protects Ischemic Injury of Subcortical White Matter in Mice Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.Wp90  0.289
1997 Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. Journal of Neurochemistry. 69: 1995-2004. PMID 9349544  0.289
2019 Shi Y, Hung ST, Rocha G, Lin S, Linares G, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. Jci Insight. 5. PMID 31310593 DOI: 10.1172/Jci.Insight.127736  0.289
2009 Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 94: 1721-31. PMID 19815836 DOI: 10.3324/Haematol.2009.009233  0.288
1992 Zlokovic BV, Mackic JB, McComb JG, Kannan R, Weiss MH. An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids. Experimental Eye Research. 54: 471-7. PMID 1381681 DOI: 10.1016/0014-4835(92)90059-2  0.287
2006 Zlokovic BV. Remodeling after stroke. Nature Medicine. 12: 390-1. PMID 16598283 DOI: 10.1038/Nm0406-390  0.287
2012 Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 1841-52. PMID 22850407 DOI: 10.1038/Jcbfm.2012.113  0.286
1991 Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. The American Journal of Physiology. 260: E633-40. PMID 1902062 DOI: 10.1152/Ajpendo.1991.260.4.E633  0.285
2023 Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging. Neuron. 111: 3131-3132. PMID 37797582 DOI: 10.1016/j.neuron.2023.09.007  0.285
1983 Zlokovic BV, Begley DJ, Chain DG. Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Research. 271: 65-71. PMID 6883121 DOI: 10.1016/0006-8993(83)91365-3  0.285
2004 Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 41: 563-72. PMID 14980205 DOI: 10.1016/S0896-6273(04)00019-4  0.284
2006 Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. The promise of protein C. Blood Cells, Molecules & Diseases. 36: 211-6. PMID 16464623 DOI: 10.1016/J.Bcmd.2005.12.023  0.284
2019 Braskie MN, Tubi MA, Thomopoulos S, Kothapalli D, Sweeney MD, Wang X, Schneider LS, Joe EB, Ringman JM, Yassine HN, Law M, Toga AW, Harrington MG, Zlokovic BV, Chui HC. P3-351: RELATIONSHIP BETWEEN CSF Aβ42 LEVELS AND HIPPOCAMPAL SUBREGION VOLUMES Alzheimer's & Dementia. 15: P1078-P1078. DOI: 10.1016/J.Jalz.2019.06.3384  0.284
2023 Contreras JA, Fujisaki K, Ortega N, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic B, Toga AW, Pa J. Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults. Research Square. PMID 36945439 DOI: 10.21203/rs.3.rs-2644974/v1  0.281
2006 Contreras JA, Sweeney MD, Sagare A, Han D, Morris JC, Fagan AM, Benzinger TL, Zlokovic B, Toga AW, Pa J. P4-316: NEUROINFLAMMATION IN ALZHEIMER'S DISEASE: TNF-α IS ASSOCIATED WITH ALTERED FUNCTIONAL CONNECTIVITY AMONG REWARD NETWORKS Alzheimer's & Dementia. 14: P1578-P1579. DOI: 10.1016/J.Jalz.2018.07.139  0.279
1994 Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye Experimental Eye Research. 59: 487-496. PMID 7859824 DOI: 10.1006/Exer.1994.1134  0.278
1991 Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. Kinetics of circulating vasopressin uptake by choroid plexus. The American Journal of Physiology. 260: F216-24. PMID 1899978 DOI: 10.1152/Ajprenal.1991.260.2.F216  0.277
2004 Guo H, Song X, Sagare A, Deane R, Zlokovic BV. P3-207 Activated protein protects neurons against Aβ (N-42, N-40) oligomers neurotoxicity Neurobiology of Aging. 25: S414. DOI: 10.1016/S0197-4580(04)81357-5  0.277
1999 Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). The Biochemical Journal. 344: 375-83. PMID 10567218 DOI: 10.1042/Bj3440375  0.272
2004 Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Activated protein C and ischemic stroke. Critical Care Medicine. 32: S247-53. PMID 15118526 DOI: 10.1097/01.Ccm.0000126127.87484.2B  0.272
2020 Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM. A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease. Translational Stroke Research. PMID 32936435 DOI: 10.1007/S12975-020-00843-8  0.271
2020 Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Conti P, Jann K, Pa J, et al. Associations between vascular function and tau PET are associated with global cognition and amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33046556 DOI: 10.1523/JNEUROSCI.1230-20.2020  0.269
2019 Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. PMID 31523028 DOI: 10.1016/J.Stem.2019.08.005  0.269
1999 Kannan R, Mackic JB, Zlokovic BV. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs Cornea. 18: 321-327. PMID 10336036 DOI: 10.1097/00003226-199905000-00014  0.268
2021 Huuskonen MT, Kisler K, Sagare AP, Zlokovic BV. On the intersection between systemic infection, brain vascular dysfunction and dementia. Brain : a Journal of Neurology. PMID 33974045 DOI: 10.1093/brain/awab168  0.267
1999 Zlokovic BV. Cerebrovascular Biology and the Various Neural Barriers: Challenges and Future Directions Neurosurgery. 44: 609-609. DOI: 10.1097/00006123-199903000-00098  0.266
2019 Lazic D, Sagare AP, Nikolakopoulou AM, Vassar RJ, Griffin JH, Zlokovic BV. P2-057: 3K3A-Activated Protein C Blocks Amyloidogenic Bace1 Pathway And Improves Functional Outcome In Mice Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2464  0.266
2019 Methner C, Mishra A, Golgotiu K, Li Y, Wei W, Yanez ND, Zlokovic B, Wang RK, Alkayed NJ, Kaul S, Iliff JJ. Pericyte constriction underlies capillary de-recruitment during hyperemia in the setting of arterial stenosis. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31125259 DOI: 10.1152/Ajpheart.00097.2019  0.264
2020 Shao X, Jann K, Ma SJ, Yan L, Montagne A, Ringman JM, Zlokovic BV, Wang DJJ. Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort. Frontiers in Neuroscience. 14: 571480. PMID 33328848 DOI: 10.3389/fnins.2020.571480  0.262
1990 Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H. Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochimica Et Biophysica Acta. 1025: 191-8. PMID 2364078 DOI: 10.1016/0005-2736(90)90097-8  0.261
2000 Zhu N, Sosnowski BA, Zlokovic BV, Ong M, Chen TC. Targeted cytotoxic gene delivery to malignant gliomas via the fibroblast growth factor receptor Neurosurgical Focus. 8: 1-8. DOI: 10.3171/Foc.2000.8.4.5  0.261
2004 Amar AP, Liu CY, Zelman V, Zlokovic B, Apuzzo ML. Advances in restorative neurosurgery: Endovascular delivery and fate determination of transplanted stem cells Seminars in Anesthesia, Perioperative Medicine and Pain. 23: 248-257. DOI: 10.1053/J.Sane.2004.01.013  0.26
2015 Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proceedings of Spie--the International Society For Optical Engineering. 9413. PMID 25859293 DOI: 10.1117/12.2081491  0.259
2004 Sallstrom JF, Brooks A, Song X, Guo H, Zlokovic BV. P3-327 Drug target gene candidates for AD microvascular cells validated using laser capture microdissection Neurobiology of Aging. 25: S448. DOI: 10.1016/S0197-4580(04)81477-5  0.258
1996 Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: Physiologic importance and manipulations Experimental Eye Research. 62: 29-37. PMID 8674510 DOI: 10.1006/Exer.1996.0004  0.257
1996 Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharmaceutical Research. 13: 290-5. PMID 8932451 DOI: 10.1023/A:1016007601794  0.255
2019 Contreras JA, Aslayan V, Sweeney MD, Sagare AP, Zlokovic BV, Toga AW, Morris JC, Fagan AM, Benzinger TL, Pa J. P2-101: CSF INTERLEUKIN-8, A KEY SIGNALING FACTOR FOR INFLAMMATION, IS ASSOCIATED WITH FUNCTIONAL CONNECTIVITY AND EXECUTIVE FUNCTION Alzheimer's & Dementia. 15: P611-P611. DOI: 10.1016/J.Jalz.2019.06.2508  0.255
2020 Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, et al. Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. Plos One. 15: e0236379. PMID 32663228 DOI: 10.1371/Journal.Pone.0236379  0.251
2013 Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Current Pharmaceutical Design. 19: 7479-85. PMID 24372304 DOI: 10.2174/1381612819666131230131454  0.249
2010 Vates GE, Takano T, Zlokovic B, Nedergaard M. Pericyte constriction after stroke: the jury is still out. Nature Medicine. 16: 959; author reply 96. PMID 20823870 DOI: 10.1038/Nm0910-959  0.246
2021 Huuskonen MT, Liu Q, Lamorie-Foote K, Shkirkova K, Connor M, Patel A, Montagne A, Baertsch H, Sioutas C, Morgan TE, Finch CE, Zlokovic BV, Mack WJ. Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion. Frontiers in Immunology. 12: 785519. PMID 34868068 DOI: 10.3389/fimmu.2021.785519  0.244
2019 Sweeney MD, Sagare AP, Harrington MG, Ringman JM, Chui HC, Toga AW, Zlokovic BV. A NOVEL ASSAY FOR A BIOMARKER OF PERICYTE INJURY IN HUMAN CEREBROSPINAL FLUID Alzheimer's & Dementia. 15: P231. DOI: 10.1016/J.Jalz.2019.06.031  0.243
1985 Mann GE, Zlokovic BV, Yudilevich DL. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochimica Et Biophysica Acta. 819: 241-8. PMID 4041458 DOI: 10.1016/0005-2736(85)90179-8  0.243
1997 Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium Experimental Eye Research. 64: 615-626. PMID 9227280 DOI: 10.1006/Exer.1996.0260  0.239
2000 Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nature Medicine. 6: 718-9. PMID 10888892 DOI: 10.1038/77397  0.238
2024 Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine. PMID 38509330 DOI: 10.1038/s41591-024-02911-0  0.238
1993 Kannan R, Tang D, Mackic JB, Zlokovic BV, Fernandez-Checa JC. A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs. Experimental Eye Research. 56: 45-50. PMID 8432334 DOI: 10.1006/Exer.1993.1007  0.237
1998 Bullock MRR, Macrae IM, Graham DJ, Zlokovic BV, Tator CH. Posttraumatic cerebral ischemia after fluid percussion brain injury: An autoradiographic and histopathological study in rats: Commentaries Neurosurgery. 43: 593-594.  0.237
2024 Wang XF, Vigouroux R, Syonov M, Baglaenko Y, Nikolakopoulou AM, Ringuette D, Rus H, DiStefano PV, Dufour S, Shabanzadeh AP, Lee S, Mueller BK, Charish J, Harada H, Fish JE, ... ... Zlokovic BV, et al. The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity. Nature Communications. 15: 1037. PMID 38310100 DOI: 10.1038/s41467-024-45303-1  0.237
2022 Kisler K, Zlokovic BV. How the brain regulates its own immune system. Nature Neuroscience. 25: 532-534. PMID 35501381 DOI: 10.1038/s41593-022-01066-w  0.236
2020 Zlokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, González HM, Schneider J, et al. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33030307 DOI: 10.1002/alz.12157  0.235
2010 Zlokovic BV. Neurodegeneration and the neurovascular unit. Nature Medicine. 16: 1370-1. PMID 21135839 DOI: 10.1038/Nm1210-1370  0.233
2022 Martinez AE, Weissberger G, Kuklenyik Z, He X, Meuret C, Parekh T, Rees JC, Parks BA, Gardner MS, King SM, Collier TS, Harrington MG, Sweeney MD, Wang X, Zlokovic BV, et al. The small HDL particle hypothesis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35416404 DOI: 10.1002/alz.12649  0.233
1996 Kittaka M, Gianotta SL, Zelman V, Weiss MH, Zlokovic BV. NICARDIPINE ATTENUATES FOCAL ISCHEMIC BRAIN INJURY IN RATS Journal of Neurosurgical Anesthesiology. 8: 332. DOI: 10.1097/00008506-199610000-00061  0.23
1997 Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs Current Eye Research. 16: 365-371. PMID 9134326 DOI: 10.1076/Ceyr.16.4.365.10688  0.229
1993 Zlokovic BV, McComb JG, Lipovac MN, Chen TC, Mackic JB, Schneider J, Gianotta SL, Weiss MH. Differential brain penetration of cerebroprotective drugs. Advances in Experimental Medicine and Biology. 331: 117-20. PMID 8333325 DOI: 10.1007/978-1-4615-2920-0_19  0.229
1993 Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME. Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. Epilepsia. 34: 201-10. PMID 8384106 DOI: 10.1111/J.1528-1157.1993.Tb02400.X  0.221
2014 Pomara N, Reichert C, Nierenberg J, Halliday MR, Sagare AP, Frangione B, Zlokovic B. P2-120: INCREASED CSF MATRIX METALLOPROTEINASE-9 (MMP-9) AND REDUCED WHITE MATTER INTEGRITY IN HEALTHY ELDERLY Alzheimer's & Dementia. 10: P515-P515. DOI: 10.1016/J.Jalz.2014.05.795  0.221
1990 Segal MB, Preston JE, Collis CS, Zlokovic BV. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. The American Journal of Physiology. 258: F1288-94. PMID 2186633 DOI: 10.1152/Ajprenal.1990.258.5.F1288  0.22
2023 Schleicher R, Vorasayan P, McCabe M, Bevers MB, Davis TP, Griffin J, Hinduja A, Jadhav A, Lee JM, Sawyer RN, Zlokovic BV, Sheth K, Fedler JK, Lyden P, Kimberly WT. Analysis of Brain Edema in RHAPSODY. International Journal of Stroke : Official Journal of the International Stroke Society. 17474930231187268. PMID 37382409 DOI: 10.1177/17474930231187268  0.219
1998 Zlokovic B. In this important study, the authors have provided additional evidence in support of the concept that iNOS Neurosurgery. 43: 1436-1436. DOI: 10.1097/00006123-199812000-00098  0.219
2023 Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, ... Zlokovic BV, et al. Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nature Aging. 1: 624. PMID 37117809 DOI: 10.1038/s43587-021-00090-y  0.219
1982 Andjelkovic I, Zlokovic B. Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. British Journal of Pharmacology. 76: 483-9. PMID 6179557 DOI: 10.1111/J.1476-5381.1982.Tb09243.X  0.217
2023 Ringman JM, Dorrani N, Fernández SG, Signer R, Martinez-Agosto J, Lee H, Douine ED, Qiao Y, Shi Y, D'Orazio L, Pawar S, Robbie L, Kashani AH, Singer M, Byers JT, ... ... Zlokovic B, et al. Characterization of spastic paraplegia in a family with a novel mutation. Brain Communications. 5: fcad030. PMID 36895955 DOI: 10.1093/braincomms/fcad030  0.216
2001 Zlokovic BV, Cox C. Lower cognitive performance of older football players possessing apolipoprotein E ε4 [5] Neurosurgery. 48: 1196-1197. PMID 11334298 DOI: 10.1097/00006123-200105000-00066  0.213
1992 Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN. Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents. Epilepsia. 32: 783-90. PMID 1743149 DOI: 10.1111/J.1528-1157.1991.Tb05534.X  0.213
2015 Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. Bmc Medical Imaging. 15: 19. PMID 26076957 DOI: 10.1186/S12880-015-0062-3  0.213
2006 Zlokovic BV. S1-02-06 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.018  0.211
1998 Hodge J, Zlokovic BV, Mayberg MR, Findlay JM. Reactive oxygen species in reoxygenation injury of rat brain capillary endothelial cells: Commentaries Neurosurgery. 43: 584.  0.209
2005 Marion DW, Zlokovic BV, Marshall LF. Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury - Commentary Neurosurgery. 56: 604.  0.209
2008 Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1505-10. PMID 18451334 DOI: 10.1161/Atvbaha.108.166066  0.207
1998 Zlokovic BV. Survival and Toxicity of an Allogeneic Cytokine-secreting Fibroblast Vaccine in the Central Nervous System Neurosurgery. 42: 340-340. DOI: 10.1097/00006123-199802000-00077  0.203
2017 Bruno D, Nierenberg J, Grothe MJ, Pratico D, Pillai A, Csernansky J, Sershen H, Marmar C, Hashimoto K, Huang Y, Teipel SJ, Zlokovic B, Zetterberg H, Blennow K, Pomara N. A Neurobiological Model Of Memory Impairment In Late-Life Major Depressive Disorder Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.2049  0.202
2013 Zlokovic BV. A gliovascular idea for the white matter repair? Journal of Neurochemistry. 125: 172-4. PMID 23441580 DOI: 10.1111/Jnc.12174  0.2
2021 Albrecht DS, Sagare A, Pachicano M, Sweeney MD, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Morris JC, Benzinger T, Pa J. Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults. Brain, Behavior, and Immunity. PMID 33486003 DOI: 10.1016/j.bbi.2021.01.010  0.196
2022 Huuskonen MT, Wang Y, Nikolakopoulou AM, Montagne A, Dai Z, Lazic D, Sagare AP, Zhao Z, Fernandez JA, Griffin JH, Zlokovic BV. Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C. The Journal of Experimental Medicine. 219. PMID 34846535 DOI: 10.1084/jem.20211372  0.196
2021 Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R, Huuskonen M, Montagne A, Baertsch H, Zhang H, Chen JC, Mack WJ, Walcott BP, Zlokovic BV, Sioutas C, et al. Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model. Environmental Health Perspectives. 129: 87006. PMID 34424052 DOI: 10.1289/EHP8792  0.195
1989 Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. European Journal of Pharmacology. 165: 155-9. PMID 2548879 DOI: 10.1016/0014-2999(89)90783-8  0.194
2019 Tubi MA, Zhou J, Hazra N, Liu JD, Kim G, Shin SH, Sweeney MD, Wang X, Schneider LS, Joe EB, Yassine HN, Ringman JM, Law M, Toga AW, Harrington MG, ... Zlokovic BV, et al. P4-056: METABOLIC SYNDROME AND DEFAULT MODE NETWORK RSFMRI CONNECTIVITY IN THE HIPPOCAMPUS Alzheimer's & Dementia. 15: P1294-P1294. DOI: 10.1016/J.Jalz.2019.06.3716  0.193
2021 Cowan RP, Gross NB, Sweeney MD, Sagare AP, Montagne A, Arakaki X, Fonteh AN, Zlokovic BV, Pogoda JM, Harrington MG. Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen. Headache. PMID 33724462 DOI: 10.1111/head.14088  0.183
2021 Zhao Z, Zlokovic BV. Acetylated tau: A missing link between head injury and dementia. Med (New York, N.Y.). 2: 637-639. PMID 35590136 DOI: 10.1016/j.medj.2021.05.005  0.179
2011 Zhong Z, Winkler EA, Zlokovic BV. Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 12: 231-2; author reply . PMID 21413850 DOI: 10.3109/17482968.2011.565776  0.179
2023 Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nature Communications. 14: 6151. PMID 37788984 DOI: 10.1038/s41467-023-40730-y  0.176
1999 Choi S, McComb JG, Levy ML, Gonzales I, Zlokovic B, Bayston R. Addition of Elemental Iodine to Surgical Irrigation for Shunt Infection Prophylaxis Neurosurgery. 45: 719-720. DOI: 10.1097/00006123-199909000-00153  0.174
2018 Attenello F, Attenello F, Wu Y, Tsung K, Mack W, Chen T, Zlokovic B. 2313 Characterization of the host pericyte role in glioblastoma angiogenesis Journal of Clinical and Translational Science. 2: 1-1. DOI: 10.1017/cts.2018.36  0.165
1995 Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Investigative Ophthalmology & Visual Science. 36: 2542-7. PMID 7591644  0.164
1989 Preston JE, Segal MB, Walley GJ, Zlokovic BV. Neutral amino acid uptake by the isolated perfused sheep choroid plexus. The Journal of Physiology. 408: 31-43. PMID 2506339 DOI: 10.1113/jphysiol.1989.sp017444  0.159
1995 Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic Lj. M. Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism European Journal of Ophthalmology. 5: 131-135. PMID 7549442  0.15
2021 Lyden PD, Pryor KE, Minigh J, Davis TP, Griffin JH, Levy H, Zlokovic BV. Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation. Frontiers in Neurology. 12: 593582. PMID 33790846 DOI: 10.3389/fneur.2021.593582  0.149
2021 Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, et al. Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell. 184: 243-256.e18. PMID 33417861 DOI: 10.1016/j.cell.2020.11.037  0.143
2023 Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Reports. 42: 113050. PMID 37597183 DOI: 10.1016/j.celrep.2023.113050  0.141
2021 Huuskonen MT, Barisano G, Chakhoyan A, Zlokovic BV. Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure". Journal of Magnetic Resonance Imaging : Jmri. PMID 34331486 DOI: 10.1002/jmri.27854  0.14
1999 CALERO M, TOKUDA T, ROSTAGNO A, KUMAR A, ZLOKOVIC B, FRANGIONE B, GHISO J. Functional and structural properties of lipid-associated apolipoprotein J (clusterin) Biochemical Journal. 344: 375-383. DOI: 10.1042/bj3440375  0.134
2015 Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, et al. Consensus statement for diagnosis of subcortical small vessel disease Journal of Cerebral Blood Flow and Metabolism. DOI: 10.1038/jcbfm.2015.172  0.134
1996 Mouw GJ, Giannotta SL, Weiss MH, DeGiorgio CM, Correale JD, Zlokovic BV. Effect of cerebral protection agents on neuron specific enolase in a rat stroke model Journal of Investigative Medicine. 44.  0.13
2022 Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by magnetic resonance imaging. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X221105668. PMID 35673963 DOI: 10.1177/0271678X221105668  0.128
2023 Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, ... ... Zlokovic BV, et al. PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell. PMID 36754049 DOI: 10.1016/j.cell.2023.01.005  0.128
1997 LAVINE SD, MOUW G, DEGIORGIO CM, CORREALE JD, ZELMAN V, ZLOKOVIC BV. CEREBRAL PROTECTION FROM THE LAZAROID DES-METHYLTIRILAZAD (U-74389) Journal of Neurosurgical Anesthesiology. 9: 396. DOI: 10.1097/00008506-199710000-00083  0.125
2020 Zhao Z, Zlokovic BV. Endothelial Tip Cell Finds Its Way with Piezo1. Neuron. 108: 5-7. PMID 33058766 DOI: 10.1016/j.neuron.2020.09.011  0.122
2024 Hansra GK, Jayasena T, Hosoki S, Poljak A, Lam BCP, Rust R, Sagare A, Zlokovic B, Thalamuthu A, Sachdev PS. Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis. Cerebral Circulation - Cognition and Behavior. 6: 100216. PMID 38510579 DOI: 10.1016/j.cccb.2024.100216  0.12
2024 Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Retraction Note: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine. PMID 38509331 DOI: 10.1038/s41591-024-02916-9  0.12
2006 Zlokovic B. ID: 330 Neuroprotective mechanisms of activated protein C Journal of Thrombosis and Haemostasis. 4: 38-38. DOI: 10.1111/j.1538-7836.2006.00330.x  0.116
2023 Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3. Neuron. 111: 4116. PMID 38135361 DOI: 10.1016/j.neuron.2023.12.001  0.115
1987 Zlokovic BV, Davson H, Preston JE, Segal MB. The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid. Experimental Neurology. 98: 436-52. PMID 2444450 DOI: 10.1016/0014-4886(87)90253-6  0.115
2003 Seki T, Hida K, Tada M, Koyanagi I, Iwasaki Y, Connolly ES, Rutka JT, Cheng T, Zlokovic BV. Role of the bcl-2 gene after contusive spinal cord injury in mice Neurosurgery. 53: 192-198. PMID 12823889  0.11
2003 Kapoor GS, O'Rourke DM, Piepmeier JM, Canute GW, Rutka JT, Zlokovic BV, Berger MS. Mitogenic signaling cascades in glial tumors Neurosurgery. 52: 1425-1435. PMID 12762887  0.103
1996 Zlokovic BV, Mackic JB, Zigler JS, Kaplowitz N, Kannan R. Lens transport of ascorbic acid in guinea pigs, normal, galactose-fed and with congenital cataract Investigative Ophthalmology and Visual Science. 37.  0.098
2021 Bakhsheshian J, Strickland BA, Mack WJ, Zlokovic BV. Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques. Spinal Cord. PMID 33742118 DOI: 10.1038/s41393-021-00623-7  0.096
2023 Chakhoyan A, Shkirkova K, Sizdahkhani S, Huuskonen MT, Lamorie-Foote K, Diaz A, Chen S, Liu Q, D'Agostino C, Zhang H, Mack WJ, Sioutas C, Finch CE, Zlokovic B, Mack WJ. Magnetic resonance imaging of white matter response to diesel exhaust particles. Research Square. PMID 37503159 DOI: 10.21203/rs.3.rs-3087503/v1  0.095
1996 Kannan R, Yi YR, Zlokovic BV, Kaplowitz N. Molecular evidence for a novel, Na+-dependent GSH transporter in rat lens epithelium Investigative Ophthalmology and Visual Science. 37.  0.083
1990 Kozlowski GP, Nilaver G, Zlokovic BV. Immunoneurology: a serum protein afferent limb to the CNS. Advances in Experimental Medicine and Biology. 274: 345-70. PMID 2239432 DOI: 10.1007/978-1-4684-5799-5_22  0.083
1996 Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Investigative Ophthalmology & Visual Science. 37: 2269-75. PMID 8843923  0.082
1988 Zloković BV, Andjelković IZ. Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart. Archives Internationales De Physiologie Et De Biochimie. 96: 7-16. PMID 2460051 DOI: 10.3109/13813458809079620  0.081
2005 Parsa AT, Lichtor T, Glick RP, Raffel C, Deane R, Zlokovic BV. Endothelial cell transplantation for gene therapy in experimental gliomas: Commentary Neurosurgery. 57: 1271.  0.076
1995 Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. Molecular characterization of a reduced glutathione transporter in the lens. Investigative Ophthalmology & Visual Science. 36: 1785-92. PMID 7635653  0.076
2024 Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R, Huuskonen M, Montagne A, Baertsch H, Zhang H, Chen JC, Mack WJ, Walcott BP, Zlokovic BV, Sioutas C, et al. Erratum: "Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model". Environmental Health Perspectives. 132: 29001. PMID 38358996 DOI: 10.1289/EHP14445  0.076
1996 Mackic JB, Kaplowitz N, Kannan R, Zlokovic BV. Glutathione synthesis from circulating sulfur amino acids is a minor source for the lens epithelial glutathione Investigative Ophthalmology and Visual Science. 37.  0.071
2021 Zhao Z, Zlokovic BV. Can prehospital "plasma supplement" neutralize the systemic storm in severe trauma? Cell Reports. Medicine. 2: 100481. PMID 35028620 DOI: 10.1016/j.xcrm.2021.100481  0.07
1994 Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. Galactose-induced cataract formation in guinea pigs: Morphologic changes and accumulation of galactitol Investigative Ophthalmology and Visual Science. 35: 804-810. PMID 8125742  0.066
2000 Kudryk BJ, Bini A, Kumar SR, Zlokovic BV. Monoclonal antibody designated T2G1 reacts with human fibrin β-chain but not with the corresponding chain from mouse fibrin (multiple letters) Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1848-1849. PMID 10894828  0.066
2022 Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling. Frontiers in Cellular Neuroscience. 16: 1078919. PMID 36523817 DOI: 10.3389/fncel.2022.1078919  0.063
2023 Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. PMID 37142785 DOI: 10.1038/s41586-023-06118-0  0.052
2005 Zlokovic BV, Liu CY. Homologous transplantation of neural stem cells to the injured spinal cord of mice: Comments Neurosurgery. 57: 1024-1025.  0.048
2002 Zlokovic BV. Advanced Drug Delivery Reviews: Preface Advanced Drug Delivery Reviews. 54: 1533-1537. PMID 12453670 DOI: 10.1016/S0169-409X(02)00147-3  0.048
2021 Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Charpak S, Smith KJ, Black SE. Reply to: Rethink the classical view of cerebrospinal fluid production. Nature Reviews. Neurology. PMID 34253900 DOI: 10.1038/s41582-021-00539-z  0.048
2015 Daianu M, Jacobs RE, Zlokovic BV, Montagne A, Thompson PM. Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice Proceedings of Spie - the International Society For Optical Engineering. 9681. DOI: 10.1117/12.2207946  0.036
2002 Kline DG, Zlokovic BV, Hodge CJ. Somatotopic organization of the facial nucleus is disrupted after lesioning and regeneration of the facial nerve: The histological representation of synkinesis. Comments Neurosurgery. 50: 362-363.  0.01
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