Josef M. Penninger - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Neuroscience Biology

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, et al. Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29109121 DOI: 10.4049/jimmunol.1600396  0.32
2016 Openshaw RL, Thomson DM, Penninger JM, Pratt JA, Morris BJ. Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline. Psychopharmacology. PMID 27774567 DOI: 10.1007/s00213-016-4463-y  0.44
2016 Haubner BJ, Schuetz T, Penninger JM. A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Research in Cardiology. 111: 64. PMID 27665606 DOI: 10.1007/s00395-016-0580-3  0.44
2016 Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, Rämö P, Rottner K, Kerkhoff E, Wada T, Penninger JM, Beerenwinkel N, Horvath P, Dehio C, Hardt WD. A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. Plos One. 11: e0161965. PMID 27627128 DOI: 10.1371/journal.pone.0161965  0.44
2016 Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H. LOX Fails to Substitute for RANKL in Osteoclastogenesis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 27606829 DOI: 10.1002/jbmr.2990  0.44
2016 Einwallner E, Kiefer FW, Di Caro G, Orthofer M, Witzeneder N, Hörmann G, Itariu B, Zeyda M, Penninger JM, Stulnig TM, Esterbauer H, Todoric J. Mast cells are not associated with systemic insulin resistance. European Journal of Clinical Investigation. PMID 27600500 DOI: 10.1111/eci.12675  0.44
2016 Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM. Inhibition of CBLB protects from lethal Candida albicans sepsis. Nature Medicine. PMID 27428901 DOI: 10.1038/nm.4134  0.44
2016 Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, ... ... Penninger JM, et al. Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 30: 147-60. PMID 27411589 DOI: 10.1016/j.ccell.2016.05.016  0.44
2016 Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, ... Penninger JM, et al. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. The Journal of Experimental Medicine. PMID 27401343 DOI: 10.1084/jem.20151780  0.44
2016 Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, ... ... Penninger JM, et al. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research. PMID 27241552 DOI: 10.1038/cr.2016.69  0.44
2016 Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, ... ... Penninger JM, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Reports. PMID 27160902 DOI: 10.1016/j.celrep.2016.04.032  0.44
2016 Rabelo LA, Todiras M, Nunes-Souza V, Qadri F, Szijártó IA, Gollasch M, Penninger JM, Bader M, Santos RA, Alenina N. Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress. Plos One. 11: e0150255. PMID 27070147 DOI: 10.1371/journal.pone.0150255  0.44
2016 Luo J, Yang Z, Ma Y, Yue Z, Lin H, Qu G, Huang J, Dai W, Li C, Zheng C, Xu L, Chen H, Wang J, Li D, Siwko S, ... Penninger JM, et al. LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nature Medicine. PMID 27064449 DOI: 10.1038/nm.4076  0.44
2016 Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kühn B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nature Protocols. 11: 542-52. PMID 26890681 DOI: 10.1038/nprot.2016.031  0.44
2016 Dufresne SS, Dumont NA, Boulanger-Piette A, Fajardo VA, Gamu D, Kake-Guena SA, David RO, Bouchard P, Lavergne É, Penninger JM, Pape PC, Tupling AR, Frenette J. Muscle RANK is a key regulator of calcium storage, SERCA activity, and function of fast-twitch skeletal muscles. American Journal of Physiology. Cell Physiology. ajpcell.00285.2015. PMID 26825123 DOI: 10.1152/ajpcell.00285.2015  0.44
2016 Dalgaard K, Landgraf K, Heyne S, Lempradl A, Longinotto J, Gossens K, Ruf M, Orthofer M, Strogantsev R, Selvaraj M, Lu TT, Casas E, Teperino R, Surani MA, Zvetkova I, ... ... Penninger JM, et al. Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity. Cell. 164: 353-364. PMID 26824653 DOI: 10.1016/j.cell.2015.12.025  0.44
2015 Haubner BJ, Schneider J, Schweigmann UU, Schuetz T, Dichtl W, Velik-Salchner C, Stein JI, Penninger JM. Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circulation Research. PMID 26659640 DOI: 10.1161/CIRCRESAHA.115.307017  0.44
2015 Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R. RANKL blockade prevents and treats aggressive osteosarcomas. Science Translational Medicine. 7: 317ra197. PMID 26659571 DOI: 10.1126/scitranslmed.aad0295  0.44
2015 Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, ... ... Penninger JM, et al. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528: 218-224. PMID 26659182 DOI: 10.1038/nature15749  0.44
2015 Lempradl A, Pospisilik JA, Penninger JM. Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nature Reviews. Genetics. 16: 665-81. PMID 26460345 DOI: 10.1038/nrg3941  0.44
2015 Nakajima K, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nature Communications. 6: 8532. PMID 26449415 DOI: 10.1038/ncomms9532  0.44
2015 Heier C, Radner FP, Moustafa T, Schreiber R, Grond S, Eichmann TO, Schweiger M, Schmidt A, Cerk IK, Oberer M, Theussl HC, Wojciechowski J, Penninger JM, Zimmermann R, Zechner R. G0/G1 Switch Gene 2 Regulates Cardiac Lipolysis. The Journal of Biological Chemistry. 290: 26141-50. PMID 26350455 DOI: 10.1074/jbc.M115.671842  0.44
2015 Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S. Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4. PMID 26327695 DOI: 10.7554/eLife.08467  0.44
2015 Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY. ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity. Diabetes. PMID 26224885 DOI: 10.2337/db15-0399  0.44
2015 Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, et al. CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. The Journal of Experimental Medicine. PMID 26195726 DOI: 10.1084/jem.20150407  0.44
2015 Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, ... ... Penninger JM, et al. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. PMID 26119026 DOI: 10.1016/j.neuron.2015.06.007  0.44
2015 Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/j.stemcr.2015.05.012  0.44
2015 Kondegowda NG, Fenutria R, Pollack IR, Orthofer M, Garcia-Ocaña A, Penninger JM, Vasavada RC. Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metabolism. 22: 77-85. PMID 26094891 DOI: 10.1016/j.cmet.2015.05.021  0.44
2015 Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, ... ... Penninger JM, et al. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 86: 1393-406. PMID 26087165 DOI: 10.1016/j.neuron.2015.05.033  0.44
2015 Kulinski TM, Casari MR, Guenzl PM, Wenzel D, Andergassen D, Hladik A, Datlinger P, Farlik M, Theussl HC, Penninger JM, Knapp S, Bock C, Barlow DP, Hudson QJ. Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Developmental Biology. 402: 291-305. PMID 25912690 DOI: 10.1016/j.ydbio.2015.04.010  0.44
2015 Nagy V, Cole T, Van Campenhout C, Khoung TM, Leung C, Vermeiren S, Novatchkova M, Wenzel D, Cikes D, Polyansky AA, Kozieradzki I, Meixner A, Bellefroid EJ, Neely GG, Penninger JM. The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle (Georgetown, Tex.). 14: 1799-808. PMID 25891934 DOI: 10.1080/15384101.2015.1036209  0.44
2015 Sun Y, Guo F, Zou Z, Li C, Hong X, Zhao Y, Wang C, Wang H, Liu H, Yang P, Han Z, Liu K, Kuba K, Song B, Gao J, ... ... Penninger JM, et al. Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Particle and Fibre Toxicology. 12: 4. PMID 25890286 DOI: 10.1186/s12989-015-0080-x  0.44
2015 Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennett DG, dos Remedios CG, Haubner BJ, Penninger JM, Kühn B. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Science Translational Medicine. 7: 281ra45. PMID 25834111 DOI: 10.1126/scitranslmed.aaa5171  0.44
2015 Grabner B, Schramek D, Mueller KM, Moll HP, Svinka J, Hoffmann T, Bauer E, Blaas L, Hruschka N, Zboray K, Stiedl P, Nivarthi H, Bogner E, Gruber W, Mohr T, ... ... Penninger JM, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nature Communications. 6: 6285. PMID 25734337 DOI: 10.1038/ncomms7285  0.44
2015 Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, ... Penninger J, et al. Autophagy in malignant transformation and cancer progression. The Embo Journal. 34: 856-80. PMID 25712477 DOI: 10.15252/embj.201490784  0.44
2015 Dufresne SS, Dumont NA, Bouchard P, Lavergne É, Penninger JM, Frenette J. Osteoprotegerin protects against muscular dystrophy. The American Journal of Pathology. 185: 920-6. PMID 25708645 DOI: 10.1016/j.ajpath.2015.01.006  0.44
2015 Guerrini MM, Okamoto K, Komatsu N, Sawa S, Danks L, Penninger JM, Nakashima T, Takayanagi H. Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System Immunity. DOI: 10.1016/j.immuni.2015.10.017  0.44
2015 Sigl V, Penninger JM. RANK and RANKL of Bones, T Cells, and the Mammary Glands Osteoimmunology: Interactions of the Immune and Skeletal Systems: Second Edition. 121-142. DOI: 10.1016/B978-0-12-800571-2.00008-6  0.44
2014 Wenzel D, Bayerl J, Nyström A, Bruckner-Tuderman L, Meixner A, Penninger JM. Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa. Science Translational Medicine. 6: 264ra165. PMID 25429058 DOI: 10.1126/scitranslmed.3010083  0.44
2014 Yang P, Gu H, Zhao Z, Wang W, Cao B, Lai C, Yang X, Zhang L, Duan Y, Zhang S, Chen W, Zhen W, Cai M, Penninger JM, Jiang C, et al. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Scientific Reports. 4: 7027. PMID 25391767 DOI: 10.1038/srep07027  0.44
2014 Wirnsberger G, Zwolanek F, Stadlmann J, Tortola L, Liu SW, Perlot T, Järvinen P, Dürnberger G, Kozieradzki I, Sarao R, De Martino A, Boztug K, Mechtler K, Kuchler K, Klein C, ... ... Penninger JM, et al. Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nature Genetics. 46: 1028-33. PMID 25129145 DOI: 10.1038/ng.3070  0.44
2014 Boztug K, Järvinen PM, Salzer E, Racek T, Mönch S, Garncarz W, Gertz EM, Schäffer AA, Antonopoulos A, Haslam SM, Schieck L, PuchaÅ‚ka J, Diestelhorst J, Appaswamy G, Lescoeur B, ... ... Penninger JM, et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nature Genetics. 46: 1021-7. PMID 25129144 DOI: 10.1038/ng.3069  0.44
2014 Itoh T, Horiuchi M, Ikeda RH, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A. ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10729-42. PMID 25100604 DOI: 10.1523/JNEUROSCI.0539-14.2014  0.44
2014 Elling U, Penninger JM. Genome wide functional genetics in haploid cells. Febs Letters. 588: 2415-21. PMID 24950427 DOI: 10.1016/j.febslet.2014.06.032  0.44
2014 Huang F, Guo J, Zou Z, Liu J, Cao B, Zhang S, Li H, Wang W, Sheng M, Liu S, Pan J, Bao C, Zeng M, Xiao H, Qian G, ... ... Penninger JM, et al. Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients. Nature Communications. 5: 3595. PMID 24800963 DOI: 10.1038/ncomms4595  0.44
2014 Zou Z, Yan Y, Shu Y, Gao R, Sun Y, Li X, Ju X, Liang Z, Liu Q, Zhao Y, Guo F, Bai T, Han Z, Zhu J, Zhou H, ... ... Penninger JM, et al. Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections. Nature Communications. 5: 3594. PMID 24800825 DOI: 10.1038/ncomms4594  0.44
2014 Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, Jhangiani SN, Wiszniewski W, Withers M, Campbell IM, Erdin S, Isikay S, Franco LM, Gonzaga-Jauregui C, Gambin T, ... ... Penninger JM, et al. Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157: 636-50. PMID 24766809 DOI: 10.1016/j.cell.2014.02.058  0.44
2014 Wang W, Patel VB, Parajuli N, Fan D, Basu R, Wang Z, Ramprasath T, Kassiri Z, Penninger JM, Oudit GY. Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. Journal of Molecular Medicine (Berlin, Germany). 92: 847-58. PMID 24728465 DOI: 10.1007/s00109-014-1149-y  0.44
2014 Kotsinas A, Papanagnou P, Galanos P, Schramek D, Townsend P, Penninger JM, Bartek J, Gorgoulis VG. MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle (Georgetown, Tex.). 13: 1227-36. PMID 24675893 DOI: 10.4161/cc.28654  0.44
2014 Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature Communications. 5: 3430. PMID 24614889 DOI: 10.1038/ncomms4430  0.44
2014 Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, ... ... Penninger JM, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507: 508-12. PMID 24553136 DOI: 10.1038/nature12998  0.44
2014 Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, ... ... Penninger JM, et al. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proceedings of the National Academy of Sciences of the United States of America. 111: 3032-7. PMID 24516159 DOI: 10.1073/pnas.1314421111  0.44
2014 Qiao G, Ying H, Zhao Y, Liang Y, Guo H, Shen H, Li Z, Solway J, Tao E, Chiang YJ, Lipkowitz S, Penninger JM, Langdon WY, Zhang J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports. 6: 709-23. PMID 24508458 DOI: 10.1016/j.celrep.2014.01.012  0.44
2014 Sigl V, Penninger JM. RANKL/RANK - from bone physiology to breast cancer. Cytokine & Growth Factor Reviews. 25: 205-14. PMID 24486161 DOI: 10.1016/j.cytogfr.2014.01.002  0.44
2014 Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, Sykacek P, Frank L, Schramek D, Komnenovic V, Sigl V, Aumayr K, Schmauss G, Fellner N, Handschuh S, ... ... Penninger JM, et al. A dual role for autophagy in a murine model of lung cancer. Nature Communications. 5: 3056. PMID 24445999 DOI: 10.1038/ncomms4056  0.44
2014 Rao S, Yang H, Penninger JM, Kroemer G. Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance. Autophagy. 10: 529-31. PMID 24413089 DOI: 10.4161/auto.27643  0.44
2013 Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K. Apelin is a positive regulator of ACE2 in failing hearts. The Journal of Clinical Investigation. 123: 5203-11. PMID 24177423 DOI: 10.1172/JCI69608  0.44
2013 Offord EA, Karagounis LG, Vidal K, Fielding R, Meydani S, Penninger JM. Nutrition and the biology of human ageing: Bone health & osteoporosis / sarcopenia / immune deficiency Journal of Nutrition, Health and Aging. 17: 712-716. PMID 24097029 DOI: 10.1007/s12603-013-0374-3  0.44
2013 Zhang ZZ, Shang QH, Jin HY, Song B, Oudit GY, Lu L, Zhou T, Xu YL, Gao PJ, Zhu DL, Penninger JM, Zhong JC. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. Journal of Translational Medicine. 11: 229. PMID 24067190 DOI: 10.1186/1479-5876-11-229  0.44
2013 Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA. Cerebral organoids model human brain development and microcephaly. Nature. 501: 373-9. PMID 23995685 DOI: 10.1038/nature12517  0.44
2013 Perlot T, Penninger JM. ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes and Infection / Institut Pasteur. 15: 866-73. PMID 23962453 DOI: 10.1016/j.micinf.2013.08.003  0.44
2013 Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nature Communications. 4: 2180. PMID 23864022 DOI: 10.1038/ncomms3180  0.44
2013 Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. Journal of the American Heart Association. 2: e000249. PMID 23817469 DOI: 10.1161/JAHA.113.000249  0.44
2013 Song B, Jin H, Yu X, Zhang Z, Yu H, Ye J, Xu Y, Zhou T, Oudit GY, Ye JY, Chen C, Gao P, Zhu D, Penninger JM, Zhong JC. Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regulatory Peptides. 185: 44-51. PMID 23816468 DOI: 10.1016/j.regpep.2013.06.007  0.44
2013 Wallner S, Lutz-Nicoladoni C, Tripp CH, Gastl G, Baier G, Penninger JM, Stoitzner P, Wolf D. The role of the e3 ligase cbl-B in murine dendritic cells. Plos One. 8: e65178. PMID 23762309 DOI: 10.1371/journal.pone.0065178  0.44
2013 Raith M, Valencia RG, Fischer I, Orthofer M, Penninger JM, Spuler S, Rezniczek GA, Wiche G. Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers. Skeletal Muscle. 3: 14. PMID 23758845 DOI: 10.1186/2044-5040-3-14  0.44
2013 Morita M, Kuba K, Ichikawa A, Nakayama M, Katahira J, Iwamoto R, Watanebe T, Sakabe S, Daidoji T, Nakamura S, Kadowaki A, Ohto T, Nakanishi H, Taguchi R, Nakaya T, ... ... Penninger JM, et al. The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell. 153: 112-25. PMID 23477864 DOI: 10.1016/j.cell.2013.02.027  0.44
2013 Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, ... ... Penninger JM, et al. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495: 474-80. PMID 23474986 DOI: 10.1038/nature11923  0.44
2013 Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (Cambridge, England). 140: 1397-401. PMID 23462470 DOI: 10.1242/dev.088948  0.44
2013 Wang W, Yang P, Zhong Y, Zhao Z, Xing L, Zhao Y, Zou Z, Zhang Y, Li C, Li T, Wang C, Wang Z, Yu X, Cao B, Gao X, ... Penninger JM, et al. Monoclonal antibody against CXCL-10/IP-10 ameliorates influenza A (H1N1) virus induced acute lung injury. Cell Research. 23: 577-80. PMID 23419516 DOI: 10.1038/cr.2013.25  0.44
2013 Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, ... ... Penninger JM, et al. Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nature Medicine. 19: 358-63. PMID 23396210 DOI: 10.1038/nm.3084  0.44
2013 Jux B, Staratschek-Jox A, Penninger JM, Schultze JL, Kolanus W. Vav1 regulates MHCII expression in murine resting and activated B cells. International Immunology. 25: 307-17. PMID 23391492 DOI: 10.1093/intimm/dxs157  0.44
2013 Kuba K, Imai Y, Penninger JM. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circulation Journal : Official Journal of the Japanese Circulation Society. 77: 301-8. PMID 23328447 DOI: DN/JST.JSTAGE/circj/CJ-12-1544  0.44
2013 Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H. Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. The Journal of Biological Chemistry. 288: 5562-71. PMID 23319583 DOI: 10.1074/jbc.M112.426080  0.44
2013 Badger-Brown KM, Gillis LC, Bailey ML, Penninger JM, Barber DL. CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing. Leukemia. 27: 1146-54. PMID 23160449 DOI: 10.1038/leu.2012.331  0.44
2013 Ichikawa A, Kuba K, Morita M, Chida S, Tezuka H, Hara H, Sasaki T, Ohteki T, Ranieri VM, dos Santos CC, Kawaoka Y, Akira S, Luster AD, Lu B, Penninger JM, et al. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. American Journal of Respiratory and Critical Care Medicine. 187: 65-77. PMID 23144331 DOI: 10.1164/rccm.201203-0508OC  0.44
2013 Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T. Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors Leukemia. 27: 118-129. PMID 22858987 DOI: 10.1038/leu.2012.222  0.44
2013 Lo J, Patel VB, Wang Z, Levasseur J, Kaufman S, Penninger JM, Oudit GY. Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Experimental Physiology. 98: 109-22. PMID 22750422 DOI: 10.1113/expphysiol.2012.067165  0.44
2013 Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon CM, Penninger JM, Carmeliet P, Li S. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis Journal of Cell Biology. 201: 165. DOI: 10.1083/jcb.2011110632011c  0.44
2012 Haubner BJ, Adamowicz-Brice M, Khadayate S, Tiefenthaler V, Metzler B, Aitman T, Penninger JM. Complete cardiac regeneration in a mouse model of myocardial infarction. Aging. 4: 966-77. PMID 23425860  0.44
2012 Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, ... ... Penninger JM, et al. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. Plos Genetics. 8: e1003071. PMID 23236288 DOI: 10.1371/journal.pgen.1003071  0.44
2012 Peña Silva RA, Chu Y, Miller JD, Mitchell IJ, Penninger JM, Faraci FM, Heistad DD. Impact of ACE2 deficiency and oxidative stress on cerebrovascular function with aging. Stroke; a Journal of Cerebral Circulation. 43: 3358-63. PMID 23160880 DOI: 10.1161/STROKEAHA.112.667063  0.44
2012 Desanti GE, Cowan JE, Baik S, Parnell SM, White AJ, Penninger JM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G. Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. Journal of Immunology (Baltimore, Md. : 1950). 189: 5519-26. PMID 23152561 DOI: 10.4049/jimmunol.1201815  0.44
2012 Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, ... ... Penninger JM, et al. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nature Medicine. 18: 1699-704. PMID 23064464 DOI: 10.1038/nm.2966  0.44
2012 Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, ... ... Penninger JM, et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell. 151: 414-26. PMID 23063129 DOI: 10.1016/j.cell.2012.09.021  0.44
2012 Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, Galluzzi L, Adjemian S, Kepp O, Niso-Santano M, Shen S, Mariño G, Criollo A, Boilève A, Job B, ... ... Penninger JM, et al. An immunosurveillance mechanism controls cancer cell ploidy. Science (New York, N.Y.). 337: 1678-84. PMID 23019653 DOI: 10.1126/science.1224922  0.44
2012 Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger JM, Loibner H, Lametschwandtner G, Wolf D, Baier G. Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. Plos One. 7: e44295. PMID 22962608 DOI: 10.1371/journal.pone.0044295  0.44
2012 Winchester CL, Ohzeki H, Vouyiouklis DA, Thompson R, Penninger JM, Yamagami K, Norrie JD, Hunter R, Pratt JA, Morris BJ. Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. Human Molecular Genetics. 21: 4910-21. PMID 22899651 DOI: 10.1093/hmg/dds331  0.44
2012 Musteanu M, Blaas L, Zenz R, Svinka J, Hoffmann T, Grabner B, Schramek D, Kantner HP, Müller M, Kolbe T, Rülicke T, Moriggl R, Kenner L, Stoiber D, Penninger JM, et al. A mouse model to identify cooperating signaling pathways in cancer Nature Methods. 9: 897-900. PMID 22863881 DOI: 10.1038/nmeth.2130  0.44
2012 Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, ... ... Penninger JM, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487: 477-81. PMID 22837003 DOI: 10.1038/nature11228  0.44
2012 Singer D, Camargo SM, Ramadan T, Schäfer M, Mariotta L, Herzog B, Huggel K, Wolfer D, Werner S, Penninger JM, Verrey F. Defective intestinal amino acid absorption in Ace2 null mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G686-95. PMID 22790597 DOI: 10.1152/ajpgi.00140.2012  0.44
2012 Guo H, Qiao G, Ying H, Li Z, Zhao Y, Liang Y, Yang L, Lipkowitz S, Penninger JM, Langdon WY, Zhang J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Reports. 1: 472-82. PMID 22763434 DOI: 10.1016/j.celrep.2012.04.008  0.44
2012 Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. The Journal of Cell Biology. 198: 103-14. PMID 22753893 DOI: 10.1083/jcb.201111063  0.44
2012 Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM, Zhong JC. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. Plos One. 7: e38502. PMID 22693641 DOI: 10.1371/journal.pone.0038502  0.44
2012 Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Sato M, Penninger JM, Yasuda H, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N. Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice Proceedings of the National Academy of Sciences of the United States of America. 109: 10006-10011. PMID 22670054 DOI: 10.1073/pnas.1207361109  0.44
2012 Arai A, Mizoguchi T, Harada S, Kobayashi Y, Nakamichi Y, Yasuda H, Penninger JM, Yamada K, Udagawa N, Takahashi N. Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment. Journal of Cell Science. 125: 2910-7. PMID 22454522 DOI: 10.1242/jcs.099986  0.44
2012 Kleinsasser A, Pircher I, Treml B, Schwienbacher M, Schuster M, Janzek E, Loibner H, Penninger JM, Loeckinger A. Recombinant angiotensin-converting enzyme 2 suppresses pulmonary vasoconstriction in acute hypoxia. Wilderness & Environmental Medicine. 23: 24-30. PMID 22441085 DOI: 10.1016/j.wem.2011.09.002  0.44
2012 Liu Z, Huang XR, Chen HY, Penninger JM, Lan HY. Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy. Laboratory Investigation; a Journal of Technical Methods and Pathology. 92: 650-61. PMID 22330342 DOI: 10.1038/labinvest.2012.2  0.44
2012 Rey-Parra GJ, Vadivel A, Coltan L, Hall A, Eaton F, Schuster M, Loibner H, Penninger JM, Kassiri Z, Oudit GY, Thébaud B. Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury Journal of Molecular Medicine. 90: 637-647. PMID 22246130 DOI: 10.1007/s00109-012-0859-2  0.44
2012 Perlot T, Penninger JM. Development and function of murine B cells lacking RANK. Journal of Immunology (Baltimore, Md. : 1950). 188: 1201-5. PMID 22219325 DOI: 10.4049/jimmunol.1102063  0.44
2012 Attané C, Foussal C, Le Gonidec S, Benani A, Daviaud D, Wanecq E, Guzmán-Ruiz R, Dray C, Bezaire V, Rancoule C, Kuba K, Ruiz-Gayo M, Levade T, Penninger J, Burcelin R, et al. Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes. 61: 310-20. PMID 22210322 DOI: 10.2337/db11-0100  0.44
2012 Douni E, Rinotas V, Makrinou E, Zwerina J, Penninger JM, Eliopoulos E, Schett G, Kollias G. A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Human Molecular Genetics. 21: 784-98. PMID 22068587 DOI: 10.1093/hmg/ddr510  0.44
2012 Lutz-Nicoladoni C, Wallner S, Stoitzner P, Pircher M, Gruber T, Wolf AM, Gastl G, Penninger JM, Baier G, Wolf D. Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. Immunology and Cell Biology. 90: 130-4. PMID 21383769 DOI: 10.1038/icb.2011.11  0.44
2012 Sigl V, Schramek D, Penninger JM. RANK and RANKL - From bones to the development of breast cancer Journal Fur Mineralstoffwechsel. 19: 27-32.  0.44
2011 Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schmauss G, Schramek D, Schnuetgen F, Von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A, ... Penninger JM, et al. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells Cell Stem Cell. 9: 563-574. PMID 22136931 DOI: 10.1016/j.stem.2011.10.012  0.44
2011 Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H. Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16872-83. PMID 22090513 DOI: 10.1523/JNEUROSCI.1111-11.2011  0.44
2011 Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, ... ... Penninger JM, et al. Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. The Journal of Experimental Medicine. 208: 2175-81. PMID 22006978 DOI: 10.1084/jem.20101890  0.44
2011 Lee AW, Mao Y, Penninger JM, Yu S. Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development. Molecular and Cellular Biology. 31: 4563-81. PMID 21930791 DOI: 10.1128/MCB.05706-11  0.44
2011 Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM. TrpA1 regulates thermal nociception in Drosophila. Plos One. 6: e24343. PMID 21909389 DOI: 10.1371/journal.pone.0024343  0.44
2011 Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nature Medicine. 17: 1231-4. PMID 21909105 DOI: 10.1038/nm.2452  0.44
2011 Muto A, Mizoguchi T, Udagawa N, Ito S, Kawahara I, Abiko Y, Arai A, Harada S, Kobayashi Y, Nakamichi Y, Penninger JM, Noguchi T, Takahashi N. Lineage-committed osteoclast precursors circulate in blood and settle down into bone. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 2978-90. PMID 21898588 DOI: 10.1002/jbmr.490  0.44
2011 Koletar MM, Cheng HY, Penninger JM, Ralph MR. Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiology International. 28: 553-62. PMID 21834641 DOI: 10.3109/07420528.2011.592235  0.44
2011 Hanada R, Penninger JM. [Central regulation of body temperature by RANKL/RANK pathway]. Clinical Calcium. 21: 1201-8. PMID 21814026  0.44
2011 Kornfeld JW, Isaacs A, Vitart V, Pospisilik JA, Meitinger T, Gyllensten U, Wilson JF, Rudan I, Campbell H, Penninger JM, Sexl V, Moriggl R, van Duijn C, Pramstaller PP, Hicks AA. Variants in STAT5B associate with serum TC and LDL-C levels. The Journal of Clinical Endocrinology and Metabolism. 96: E1496-501. PMID 21752895 DOI: 10.1210/jc.2011-0322  0.44
2011 Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G. Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. Journal of Autoimmunity. 37: 198-208. PMID 21700422 DOI: 10.1016/j.jaut.2011.05.018  0.44
2011 Oudit GY, Penninger JM. Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy Current Heart Failure Reports. 8: 176-183. PMID 21611889 DOI: 10.1007/s11897-011-0063-7  0.44
2011 Jin R, Song Z, Yu S, Piazza A, Nanda A, Penninger JM, Granger DN, Li G. Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke Stroke. 42: 2033-2044. PMID 21546487 DOI: 10.1161/STROKEAHA.110.601369  0.44
2011 Schramek D, Sigl V, Penninger JM. RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis Trends in Endocrinology and Metabolism. 22: 188-194. PMID 21470874 DOI: 10.1016/j.tem.2011.02.007  0.44
2011 Taschler U, Radner FP, Heier C, Schreiber R, Schweiger M, Schoiswohl G, Preiss-Landl K, Jaeger D, Reiter B, Koefeler HC, Wojciechowski J, Theussl C, Penninger JM, Lass A, Haemmerle G, et al. Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. The Journal of Biological Chemistry. 286: 17467-77. PMID 21454566 DOI: 10.1074/jbc.M110.215434  0.44
2011 Hanada R, Hanada T, Sigl V, Schramek D, Penninger JM. RANKL/RANK-beyond bones Journal of Molecular Medicine. 89: 647-656. PMID 21445556 DOI: 10.1007/s00109-011-0749-z  0.44
2011 Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, et al. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. Journal of Immunology (Baltimore, Md. : 1950). 186: 5047-57. PMID 21441458 DOI: 10.4049/jimmunol.1003533  0.44
2011 Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression Nature Genetics. 43: 212-219. PMID 21317887 DOI: 10.1038/ng.767  0.44
2011 Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovascular Research. 91: 151-61. PMID 21285291 DOI: 10.1093/cvr/cvr036  0.44
2011 Paolino M, Thien CB, Gruber T, Hinterleitner R, Baier G, Langdon WY, Penninger JM. Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. Journal of Immunology (Baltimore, Md. : 1950). 186: 2138-47. PMID 21248250 DOI: 10.4049/jimmunol.1003390  0.44
2011 Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY. Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57: 314-22. PMID 21189404 DOI: 10.1161/HYPERTENSIONAHA.110.164244  0.44
2011 Zhong JC, Ye JY, Jin HY, Yu X, Yu HM, Zhu DL, Gao PJ, Huang DY, Shuster M, Loibner H, Guo JM, Yu XY, Xiao BX, Gong ZH, Penninger JM, et al. Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regulatory Peptides. 166: 90-7. PMID 20854846 DOI: 10.1016/j.regpep.2010.09.005  0.44
2011 Leibbrandt A, Penninger JM. TNF conference 2009: Beyond bones - RANKL/RANK in the immune system Advances in Experimental Medicine and Biology. 691: 5-22. DOI: 10.1007/978-1-4419-6612-4_2  0.44
2010 Hanada R, Hanada T, Penninger JM. Physiology and pathophysiology of the RANKL/RANK system Biological Chemistry. 391: 1365-1370. PMID 21087090 DOI: 10.1515/BC.2010.149  0.44
2010 Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, ... ... Penninger JM, et al. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143: 628-38. PMID 21074052 DOI: 10.1016/j.cell.2010.09.047  0.44
2010 Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, ... Penninger JM, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468: 98-102. PMID 20881962 DOI: 10.1038/nature09387  0.44
2010 Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY. Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circulation Research. 107: 1275-89. PMID 20847309 DOI: 10.1161/CIRCRESAHA.110.229054  0.44
2010 Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, Loibner H, Wang XH, Penninger JM, Kassiri Z, Oudit GY. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 122: 717-28, 18 p followi. PMID 20679547 DOI: 10.1161/CIRCULATIONAHA.110.955369  0.44
2010 Jin R, Yu S, Song Z, Quillin JW, Deasis DP, Penninger JM, Nanda A, Granger DN, Li G. Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke Biochemical and Biophysical Research Communications. 399: 458-464. PMID 20678469 DOI: 10.1016/j.bbrc.2010.07.116  0.44
2010 Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacology & Therapeutics. 128: 119-28. PMID 20599443 DOI: 10.1016/j.pharmthera.2010.06.003  0.44
2010 Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, Nishina H. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Journal of Cellular Biochemistry. 110: 1022-37. PMID 20564202 DOI: 10.1002/jcb.22616  0.44
2010 Paolino M, Penninger JM. Cbl-b in T-cell activation Seminars in Immunopathology. 32: 137-148. PMID 20458601 DOI: 10.1007/s00281-010-0197-9  0.44
2010 Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, ... ... Penninger JM, et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141: 142-53. PMID 20371351 DOI: 10.1016/j.cell.2010.02.023  0.44
2010 Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño JE, Baba HA, Abramowitz J, Birnbaumer L, Penninger JM, Pongs O, et al. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Research in Cardiology. 105: 583-95. PMID 20352235 DOI: 10.1007/s00395-010-0098-z  0.44
2010 Meixner A, Karreth F, Kenner L, Penninger JM, Wagner EF. Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death and Differentiation. 17: 1409-19. PMID 20300111 DOI: 10.1038/cdd.2010.22  0.44
2010 Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B. PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. Plos One. 5: e9350. PMID 20179753 DOI: 10.1371/journal.pone.0009350  0.44
2010 Imai Y, Kuba K, Ohto-Nakanishi T, Penninger JM. Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circulation Journal : Official Journal of the Japanese Circulation Society. 74: 405-10. PMID 20134095 DOI: JST.JSTAGE/circj/CJ-10-0045  0.44
2010 Fleuren ED, O'Toole S, Millar EK, McNeil C, Lopez-Knowles E, Boulghourjian A, Croucher DR, Schramek D, Brummer T, Penninger JM, Sutherland RL, Daly RJ. Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. International Journal of Cancer. Journal International Du Cancer. 127: 1486-92. PMID 20087860 DOI: 10.1002/ijc.25172  0.44
2010 Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, ... ... Penninger JM, et al. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140: 148-60. PMID 20074523 DOI: 10.1016/j.cell.2009.12.027  0.44
2010 Xu H, Su Z, Wu J, Yang M, Penninger JM, Martin CM, Kvietys PR, Rui T. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. Journal of Immunology (Baltimore, Md. : 1950). 184: 1492-8. PMID 20028656 DOI: 10.4049/jimmunol.0902660  0.44
2010 Awad AE, Kandalam V, Chakrabarti S, Wang X, Penninger JM, Davidge ST, Oudit GY, Kassiri Z. Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. American Journal of Physiology. Cell Physiology. 298: C679-92. PMID 20007453 DOI: 10.1152/ajpcell.00351.2009  0.44
2010 Leibbrandt A, Penninger JM. Novel functions of RANK(L) signaling in the immune system Advances in Experimental Medicine and Biology. 658: 77-94. PMID 19950018 DOI: 10.1007/978-1-4419-1050-9_9  0.44
2010 Wysocki J, Ye M, Rodriguez E, González-Pacheco FR, Barrios C, Evora K, Schuster M, Loibner H, Brosnihan KB, Ferrario CM, Penninger JM, Batlle D. Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: Prevention of angiotensin II-dependent hypertension Hypertension. 55: 90-98. PMID 19948988 DOI: 10.1161/HYPERTENSIONAHA.109.138420  0.44
2010 Oudit GY, Liu GC, Zhong J, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW. Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes. 59: 529-38. PMID 19934006 DOI: 10.2337/db09-1218  0.44
2010 Saade M, Irla M, Yammine M, Boulanger N, Victorero G, Vincentelli R, Penninger JM, Holländer GA, Chauvet S, Nguyen C. Spatial (Tbata) expression in mature medullary thymic epithelial cells. European Journal of Immunology. 40: 530-8. PMID 19918778 DOI: 10.1002/eji.200939605  0.44
2010 Oudit GY, Liu GC, Zhong J, Basu R, Chow FL, Zhou J, Loibner H, Janzek E, Schuster M, Penninger JM, Herzenberg AM, Kassiri Z, Scholey JW. Human recombinant ACE2 reduces the progression of diabetic nephropathy (Diabetes (2010) 59, (529-538)) Diabetes. 59: 1113-1114. DOI: 10.2337/db10-er04  0.44
2009 Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, ... ... Penninger JM, et al. Central control of fever and female body temperature by RANKL/RANK. Nature. 462: 505-9. PMID 19940926 DOI: 10.1038/nature08596  0.44
2009 Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, ... ... Penninger JM, et al. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of Experimental Medicine. 206: 2351-64. PMID 19822644 DOI: 10.1084/jem.20091436  0.44
2009 Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circulation. Heart Failure. 2: 446-55. PMID 19808375 DOI: 10.1161/CIRCHEARTFAILURE.108.840124  0.44
2009 Leibbrandt A, Penninger JM. ESCI award lecture: From a little mouse to rationale medicine for bone loss European Journal of Clinical Investigation. 39: 842-850. PMID 19772521 DOI: 10.1111/j.1365-2362.2009.02215.x  0.44
2009 Blyszczuk P, Kania G, Dieterle T, Marty RR, Valaperti A, Berthonneche C, Pedrazzini T, Berger CT, Dirnhofer S, Matter CM, Penninger JM, Lüscher TF, Eriksson U. Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circulation Research. 105: 912-20. PMID 19762681 DOI: 10.1161/CIRCRESAHA.109.199802  0.44
2009 Leibbrandt A, Penninger JM. RANK(L) as a key target for controlling bone loss Advances in Experimental Medicine and Biology. 647: 130-145. PMID 19760071 DOI: 10.1007/978-0-387-89520-8_9  0.44
2009 Leibbrandt A, Penninger JM. RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies Advances in Experimental Medicine and Biology. 649: 100-113. PMID 19731623 DOI: 10.1007/978-1-4419-0298-6_7  0.44
2009 Joza N, Pospisilik JA, Hangen E, Hanada T, Modjtahedi N, Penninger JM, Kroemer G. AIF: Not just an apoptosis-inducing factor Annals of the New York Academy of Sciences. 1171: 2-11. PMID 19723031 DOI: 10.1111/j.1749-6632.2009.04681.x  0.44
2009 Paolino M, Penninger JM. E3 ubiquitin ligases in T-cell tolerance European Journal of Immunology. 39: 2337-2344. PMID 19714573 DOI: 10.1002/eji.200939662  0.44
2009 Köcher T, Pichler P, Schutzbier M, Stingl C, Kaul A, Teucher N, Hasenfuss G, Penninger JM, Mechtler K. High precision quantitative proteomics using iTRAQ on an LTQ Orbitrap: A new mass spectrometric method combining the benefits of all Journal of Proteome Research. 8: 4743-4752. PMID 19663507 DOI: 10.1021/pr900451u  0.44
2009 Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (Baltimore, Md.). 50: 929-38. PMID 19650157 DOI: 10.1002/hep.23104  0.44
2009 Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G. PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Science Signaling. 2: ra30. PMID 19549985 DOI: 10.1126/scisignal.2000046  0.44
2009 Cronin SJF, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, De Simoes RM, Gruber S, Puc U, Ebersberger I, Zoranovic T, Neely GG, Von Haeseler A, Ferrandon D, ... Penninger JM, et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection Science. 325: 340-343. PMID 19520911 DOI: 10.1126/science.1173164  0.44
2009 Singer D, Camargo SM, Huggel K, Romeo E, Danilczyk U, Kuba K, Chesnov S, Caron MG, Penninger JM, Verrey F. Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3. The Journal of Biological Chemistry. 284: 19953-60. PMID 19478081 DOI: 10.1074/jbc.M109.011171  0.44
2009 Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, Butany J. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS European Journal of Clinical Investigation. 39: 618-625. PMID 19453650 DOI: 10.1111/j.1365-2362.2009.02153.x  0.44
2009 Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, ... ... Penninger JM, et al. Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. The Journal of Cell Biology. 184: 541-54. PMID 19237598 DOI: 10.1083/jcb.200806139  0.44
2009 Oudit GY, Imai Y, Kuba K, Scholey JW, Penninger JM. The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 24: 1362-5. PMID 19228756 DOI: 10.1093/ndt/gfp065  0.44
2009 Camargo SM, Singer D, Makrides V, Huggel K, Pos KM, Wagner CA, Kuba K, Danilczyk U, Skovby F, Kleta R, Penninger JM, Verrey F. Tissue-specific amino acid transporter partners ACE2 and collectrin differentially interact with hartnup mutations. Gastroenterology. 136: 872-82. PMID 19185582 DOI: 10.1053/j.gastro.2008.10.055  0.44
2009 Oudit GY, Penninger JM. Cardiac regulation by phosphoinositide 3-kinases and PTEN Cardiovascular Research. 82: 250-260. PMID 19147653 DOI: 10.1093/cvr/cvp014  0.44
2009 Fontán-Lozano A, Romero-Granados R, del-Pozo-Martín Y, Suárez-Pereira I, Delgado-García JM, Penninger JM, Carrión AM. Lack of DREAM protein enhances learning and memory and slows brain aging. Current Biology : Cb. 19: 54-60. PMID 19110430 DOI: 10.1016/j.cub.2008.11.056  0.44
2009 Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H. Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. Journal of Biochemistry. 145: 345-54. PMID 19106158 DOI: 10.1093/jb/mvn172  0.44
2009 Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Response to Angiotensinconverting enzyme 2 (ACE2) gene and protein expression in diabetic patients without nephropathy Kidney International. 75: 1119. DOI: 10.1038/ki.2009.47  0.44
2009 Fontán-Lozano A, Romero-Granados R, del-Pozo-Martín Y, Suárez-Pereira I, Delgado-García JM, Penninger JM, Carrión AM. Lack of DREAM Protein Enhances Learning and Memory and Slows Brain Aging (DOI:10.1016/j.cub.2008.11.056) Current Biology. 19: 1332. DOI: 10.1016/j.cub.2009.06.055  0.44
2009 Loeser S, Penninger JM. Regulation of T Cell Anergy and Escape from Regulatory T Cell Suppression by Cbl-b The Epigenetics of Autoimmune Diseases. 75-94. DOI: 10.1002/9780470743553.ch5  0.44
2008 Leibbrandt A, Penninger JM. RANK/RANKL: Regulators of immune responses and bone physiology Annals of the New York Academy of Sciences. 1143: 123-150. PMID 19076348 DOI: 10.1196/annals.1443.016  0.44
2008 Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease Kidney International. 74: 1610-1616. PMID 19034303 DOI: 10.1038/ki.2008.497  0.44
2008 Raberger J, Boucheron N, Sakaguchi S, Penninger JM, Ellmeier W. Impaired T-cell development in the absence of Vav1 and Itk European Journal of Immunology. 38: 3530-3542. PMID 19009524 DOI: 10.1002/eji.200838388  0.44
2008 Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue Ji, Akiyama T, et al. The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator Immunity. 29: 438-450. PMID 18799150 DOI: 10.1016/j.immuni.2008.06.018  0.44
2008 Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29: 423-37. PMID 18799149 DOI: 10.1016/j.immuni.2008.06.015  0.44
2008 Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circulation Research. 103: 643-53. PMID 18688045 DOI: 10.1161/CIRCRESAHA.108.175018  0.44
2008 Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1377-84. PMID 18660448 DOI: 10.1152/ajpheart.00331.2008  0.44
2008 Meixner A, Zenz R, Schonthaler HB, Kenner L, Scheuch H, Penninger JM, Wagner EF. Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nature Cell Biology. 10: 1003-11. PMID 18641637 DOI: 10.1038/ncb1761  0.44
2008 Imai Y, Kuba K, Penninger JM. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Experimental Physiology. 93: 543-8. PMID 18448662 DOI: 10.1113/expphysiol.2007.040048  0.44
2008 Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, ... ... Penninger JM, et al. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133: 235-49. PMID 18423196 DOI: 10.1016/j.cell.2008.02.043  0.44
2008 Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart Experimental Physiology. 93: 613-621. PMID 18356559 DOI: 10.1113/expphysiol.2007.040246  0.44
2008 Joza N, Galindo K, Pospisilik JA, Benit P, Rangachari M, Kanitz EE, Nakashima Y, Neely GG, Rustin P, Abrams JM, Kroemer G, Penninger JM. The molecular archaeology of a mitochondrial death effector: AIF in Drosophila Cell Death and Differentiation. 15: 1009-1018. PMID 18309327 DOI: 10.1038/cdd.2008.24  0.44
2008 Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovascular Research. 78: 505-14. PMID 18281373 DOI: 10.1093/cvr/cvn041  0.44
2008 Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death and Differentiation. 15: 89-93. PMID 17762881 DOI: 10.1038/sj.cdd.4402222  0.44
2008 Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T. Cell type-specific regulation of ITAM-mediated NF-κB activation by the adaptors, CARMA1 and CARD9 Journal of Immunology. 181: 918-930.  0.44
2007 Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Markovic M, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, ... ... Penninger JM, et al. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circulation Research. 101: e32-42. PMID 17673668 DOI: 10.1161/CIRCRESAHA.107.158659  0.44
2007 Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. The American Journal of Pathology. 171: 438-51. PMID 17600118 DOI: 10.2353/ajpath.2007.060977  0.44
2007 Imai Y, Kuba K, Penninger JM. Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cellular and Molecular Life Sciences : Cmls. 64: 2006-12. PMID 17558469 DOI: 10.1007/s00018-007-6228-6  0.44
2006 Danilczyk U, Sarao R, Remy C, Benabbas C, Stange G, Richter A, Arya S, Pospisilik JA, Singer D, Camargo SM, Makrides V, Ramadan T, Verrey F, Wagner CA, Penninger JM. Essential role for collectrin in renal amino acid transport. Nature. 444: 1088-91. PMID 17167413 DOI: 10.1038/nature05475  0.44
2006 Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12984-95. PMID 17167088 DOI: 10.1523/JNEUROSCI.4253-06.2006  0.44
2006 Kuba K, Imai Y, Rao S, Jiang C, Penninger JM. Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. Journal of Molecular Medicine (Berlin, Germany). 84: 814-20. PMID 16988814 DOI: 10.1007/s00109-006-0094-9  0.44
2006 Cheung EC, Joza N, Steenaart NA, McClellan KA, Neuspiel M, McNamara S, MacLaurin JG, Rippstein P, Park DS, Shore GC, McBride HM, Penninger JM, Slack RS. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. The Embo Journal. 25: 4061-73. PMID 16917506 DOI: 10.1038/sj.emboj.7601276  0.44
2006 Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, ... ... Penninger JM, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442: 457-60. PMID 16871217 DOI: 10.1038/nature04925  0.44
2006 Brown D, Yu BD, Joza N, Bénit P, Meneses J, Firpo M, Rustin P, Penninger JM, Martin GR. Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proceedings of the National Academy of Sciences of the United States of America. 103: 9918-23. PMID 16788063 DOI: 10.1073/pnas.0603950103  0.44
2006 Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. The American Journal of Pathology. 168: 1808-20. PMID 16723697 DOI: 10.2353/ajpath.2006.051091  0.44
2006 Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Current Opinion in Pharmacology. 6: 271-6. PMID 16581295 DOI: 10.1016/j.coph.2006.03.001  0.44
2006 Imai Y, Kuba K, Penninger JM. The renin-angiotensin system in acute respiratory distress syndrome Drug Discovery Today: Disease Mechanisms. 3: 225-229. DOI: 10.1016/j.ddmec.2006.06.012  0.44
2005 Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, ... ... Penninger JM, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nature Medicine. 11: 875-9. PMID 16007097 DOI: 10.1038/nm1267  0.44
2005 Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, ... ... Penninger JM, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436: 112-6. PMID 16001071 DOI: 10.1038/nature03712  0.44
2005 Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S. Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nature Cell Biology. 7: 405-11. PMID 15793568 DOI: 10.1038/ncb1237  0.44
2005 Puri KD, Doggett TA, Huang CY, Douangpanya J, Hayflick JS, Turner M, Penninger J, Diacovo TG. The role of endothelial PI3Kγ activity in neutrophil trafficking Blood. 106: 150-157. PMID 15769890 DOI: 10.1182/blood-2005-01-0023  0.44
2005 Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, ... ... Penninger JM, et al. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. The Journal of Experimental Medicine. 201: 859-70. PMID 15767368 DOI: 10.1084/jem.20041891  0.44
2005 Krawczyk CM, Jones RG, Atfteld A, Bachmaier K, Arya S, Odermatt B, Ohashi PS, Penninger JM. Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b Journal of Immunology. 174: 1472-1478. PMID 15661906  0.44
2005 Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, ... ... Penninger JM, et al. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes & Development. 19: 208-13. PMID 15655111 DOI: 10.1101/gad.327005  0.44
2004 Vahsen N, Candé C, Brière JJ, Bénit P, Joza N, Larochette N, Mastroberardino PG, Pequignot MO, Casares N, Lazar V, Feraud O, Debili N, Wissing S, Engelhardt S, Madeo F, ... ... Penninger JM, et al. AIF deficiency compromises oxidative phosphorylation. The Embo Journal. 23: 4679-89. PMID 15526035 DOI: 10.1038/sj.emboj.7600461  0.44
2004 Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. The Journal of Experimental Medicine. 200: 1167-77. PMID 15520247 DOI: 10.1084/jem.20032246  0.44
2004 Cheng HY, Penninger JM. DREAMing about arthritic pain. Annals of the Rheumatic Diseases. ii72-ii75. PMID 15479877 DOI: 10.1136/ard.2004.029942  0.36
2004 Matsumoto G, Kubota E, Omi Y, Lee U, Penninger JM. Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 4976-84. PMID 15470040 DOI: 10.4049/JIMMUNOL.173.8.4976  0.44
2004 Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS. TCR affinity and negative regulation limit autoimmunity. Nature Medicine. 10: 1234-9. PMID 15467726 DOI: 10.1038/nm1114  0.44
2004 Cheng HY, Obrietan K, Cain SW, Lee BY, Agostino PV, Joza NA, Harrington ME, Ralph MR, Penninger JM. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 43: 715-28. PMID 15339652 DOI: 10.1016/j.neuron.2004.08.021  0.44
2004 Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones R, Gronski M, Ohashi P, Wada T, ... ... Penninger JM, et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction Immunity. 21: 167-177. PMID 15308098 DOI: 10.1016/j.immuni.2004.07.013  0.44
2004 Wang X, Huang G, Luo X, Penninger JM, Muallem S. Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. The Journal of Biological Chemistry. 279: 41642-9. PMID 15292238 DOI: 10.1074/jbc.M406450200  0.44
2004 Fischer L, Gukovskaya AS, Young SH, Gukovsky I, Lugea A, Buechler P, Penninger JM, Friess H, Pandol SJ. Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G1200-12. PMID 15271649 DOI: 10.1152/ajpgi.00212.2004  0.44
2004 Cheng HY, Laviolette SR, van der Kooy D, Penninger JM. DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. The European Journal of Neuroscience. 19: 3033-41. PMID 15182311 DOI: 10.1111/j.0953-816X.2004.03435.x  0.44
2004 Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nature Cell Biology. 6: 215-26. PMID 15039780 DOI: 10.1038/ncb1098  0.88
2004 Candé C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, Luban J, Kroemer RT, Giordanetto F, Garrido C, Penninger JM, Kroemer G. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis Oncogene. 23: 1514-1521. PMID 14716299 DOI: 10.1038/sj.onc.1207279  0.44
2003 Griffiths EK, Sanchez O, Mill P, Krawczyk C, Hojilla CV, Rubin E, Nau MM, Khokha R, Lipkowitz S, Hui CC, Penninger JM. Cbl-3-deficient mice exhibit normal epithelial development. Molecular and Cellular Biology. 23: 7708-18. PMID 14560016 DOI: 10.1128/MCB.23.21.7708-7718.2003  0.44
2003 Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, ... Penninger JM, et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18: 763-75. PMID 12818158 DOI: 10.1016/S1074-7613(03)00148-1  0.44
2003 Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA, Glynne RJ, Nelms KA, Goodnow CC. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18: 751-62. PMID 12818157 DOI: 10.1016/S1074-7613(03)00141-9  0.44
2003 Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. The Journal of Clinical Investigation. 111: 1259. PMID 12697745  0.44
2003 Suzuki N, Chen NJ, Millar DG, Suzuki S, Horacek T, Hara H, Bouchard D, Nakanishi K, Penninger JM, Ohashi PS, Yeh WC. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. Journal of Immunology (Baltimore, Md. : 1950). 170: 4031-5. PMID 12682231  0.44
2003 Cheng HY, Penninger JM. When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opinion On Therapeutic Targets. 7: 249-63. PMID 12667101 DOI: 10.1517/14728222.7.2.249  0.88
2003 Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. The Journal of Clinical Investigation. 111: 445-52. PMID 12588882 DOI: 10.1172/JCI15598  0.44
2002 Cheng HY, Penninger JM. Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Expert Review of Neurotherapeutics. 2: 677-89. PMID 19810984 DOI: 10.1586/14737175.2.5.677  0.88
2002 Matsumoto G, Tsunematsu S, Tsukinoki K, Ohmi Y, Iwamiya M, Oliveira-dos-Santos A, Tone D, Shindo J, Penninger JM. Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis. Journal of Immunology (Baltimore, Md. : 1950). 169: 7087-96. PMID 12471145 DOI: 10.4049/JIMMUNOL.169.12.7087  0.44
2002 Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, ... ... Penninger JM, et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110: 737-49. PMID 12297047 DOI: 10.1016/S0092-8674(02)00969-8  0.88
2002 Tani-Ishii N, Penninger JM, Matsumoto G, Teranaka T, Umemoto T. The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. Journal of Periodontal Research. 37: 184-91. PMID 12113552 DOI: 10.1034/J.1600-0765.2002.00610.X  0.44
2002 Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, ... ... Penninger JM, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417: 822-8. PMID 12075344 DOI: 10.1038/nature00786  0.44
2002 Griffiths EK, Penninger JM. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Current Opinion in Immunology. 14: 317-22. PMID 11973129  0.76
2002 Griffiths EK, Penninger JM. ADAP-ting TCR signaling to integrins. Science's Stke : Signal Transduction Knowledge Environment. 2002: re3. PMID 11943877 DOI: 10.1126/stke.2002.127.re3  0.76
2002 Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16: 331-43. PMID 11911819 DOI: 10.1016/S1074-7613(02)00291-1  0.44
2002 Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, ... ... Penninger JM, et al. DREAM is a critical transcriptional repressor for pain modulation. Cell. 108: 31-43. PMID 11792319 DOI: 10.1016/S0092-8674(01)00629-8  0.44
2002 Kim HJ, Yoon MJ, Lee J, Penninger JM, Kong YY. Osteoprotegerin ligand induces beta-casein gene expression through the transcription factor CCAAT/enhancer-binding protein beta. The Journal of Biological Chemistry. 277: 5339-44. PMID 11726661 DOI: 10.1074/jbc.M108342200  0.44
2001 Mak TW, Penninger JM, Ohashi PS. Knockout mice: A paradigm shift in modern immunology Nature Reviews Immunology. 1: 11-19. PMID 11905810  0.44
2001 Griffiths EK, Krawczyk C, Kong YY, Raab M, Hyduk SJ, Bouchard D, Chan VS, Kozieradzki I, Oliveira-Dos-Santos AJ, Wakeham A, Ohashi PS, Cybulsky MI, Rudd CE, Penninger JM. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science (New York, N.Y.). 293: 2260-3. PMID 11567140 DOI: 10.1126/science.1063397  0.76
2001 Sasaki T, Wada T, Kishimoto H, Irie-Sasaki J, Matsumoto G, Goto T, Yao Z, Wakeham A, Mak TW, Suzuki A, Cho SK, Zuniga-Pflucker JC, Oliveira-dos-Santos AJ, Katada T, Nishina H, ... Penninger JM, et al. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. The Journal of Experimental Medicine. 194: 757-68. PMID 11560992 DOI: 10.1084/jem.194.6.757  0.44
2001 Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, ... ... Penninger JM, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410: 549-54. PMID 11279485 DOI: 10.1038/35069004  0.88
2001 Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, ... Penninger JM, et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 409: 349-54. PMID 11201744 DOI: 10.1038/35053086  0.44
2000 Matsumoto G, Omi Y, Lee U, Nishimura T, Shindo J, Penninger JM. Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. European Journal of Immunology. 30: 3723-31. PMID 11169416 DOI: 10.1002/1521-4141(200012)30:12<3723::AID-IMMU3723>3.0.CO;2-9  0.44
2000 Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13: 463-73. PMID 11070165  0.44
2000 Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103: 41-50. PMID 11051546 DOI: 10.1016/S0092-8674(00)00103-3  0.44
2000 Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, Penninger JM. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proceedings of the National Academy of Sciences of the United States of America. 97: 12272-7. PMID 11027316 DOI: 10.1073/pnas.220414397  0.44
2000 Sasaki T, Irie-Sasaki J, Horie Y, Bachmaler K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, ... ... Penninger JM, et al. Colorectal carcinomas in mice lacking the catalytic submit of PI(3)kγ Nature. 406: 897-902. PMID 10972292 DOI: 10.1038/35022585  0.44
2000 Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prévost MC, Brothers G, Mak TW, Penninger J, Earnshaw WC, Kroemer G. Two distinct pathways leading to nuclear apoptosis. The Journal of Experimental Medicine. 192: 571-80. PMID 10952727 DOI: 10.1084/jem.192.4.571  0.44
2000 Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nature Medicine. 6: 429-34. PMID 10742150 DOI: 10.1038/74689  0.44
2000 Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-Dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration Science. 287: 1040-4046. PMID 10669416 DOI: 10.1126/science.287.5455.1040  0.44
2000 Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, ... Penninger JM, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403: 211-6. PMID 10646608 DOI: 10.1038/35003228  0.44
1999 Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, ... ... Penninger JM, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 402: 304-9. PMID 10580503 DOI: 10.1038/46303  0.32
1999 Penninger JM, Fischer KD, Sasaki T, Kozieradzki I, Le J, Tedford K, Bachmaier K, Ohashi PS, Bachmann MF. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. European Journal of Immunology. 29: 1709-18. PMID 10359126 DOI: 10.1002/(SICI)1521-4141(199905)29:05<1709::AID-IMMU1709>3.0.CO;2-O  0.44
1999 Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, ... ... Penninger JM, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes & Development. 13: 1015-24. PMID 10215628 DOI: 10.1101/gad.13.8.1015  0.44
1999 Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM. Chlamydia infections and heart disease linked through antigenic mimicry. Science (New York, N.Y.). 283: 1335-9. PMID 10037605 DOI: 10.1126/science.283.5406.1335  0.44
1998 Kong YY, Fischer KD, Bachmann MF, Mariathasan S, Kozieradzki I, Nghiem MP, Bouchard D, Bernstein A, Ohashi PS, Penninger JM. Vav regulates peptide-specific apoptosis in thymocytes. The Journal of Experimental Medicine. 188: 2099-111. PMID 9841924 DOI: 10.1084/jem.188.11.2099  0.44
1998 Liu Q, Oliveira-Dos-Santos AJ, Mariathasan S, Bouchard D, Jones J, Sarao R, Kozieradzki I, Ohashi PS, Penninger JM, Dumont DJ. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. The Journal of Experimental Medicine. 188: 1333-42. PMID 9763612 DOI: 10.1084/jem.188.7.1333  0.44
1998 Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94: 339-52. PMID 9708736 DOI: 10.1016/S0092-8674(00)81477-4  0.44
1998 Fischer KD, Kong YY, Nishina H, Tedford K, Marengère LE, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Current Biology : Cb. 8: 554-62. PMID 9601639 DOI: 10.1016/S0960-9822(98)70224-6  0.44
1998 Yoshida H, Nishina H, Takimoto H, Marengère LE, Wakeham AC, Bouchard D, Kong YY, Ohteki T, Shahinian A, Bachmann M, Ohashi PS, Penninger JM, Crabtree GR, Mak TW. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 8: 115-24. PMID 9462517 DOI: 10.1016/S1074-7613(00)80464-1  0.32
1997 Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice European Journal of Immunology. 27: 1887-1892. PMID 9295023 DOI: 10.1002/eji.1830270811  0.44
1997 Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, Wakeham A, Shahinian A, Takimoto H, Bernstein A, Mak TW, Woodgett JR, Ohashi PS, Penninger JM. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. The Journal of Experimental Medicine. 186: 941-53. PMID 9294148 DOI: 10.1084/jem.186.6.941  0.44
1997 Nishina H, Fischer KD, Radvanyi L, Shahinian A, Hakem R, Rubie EA, Bernstein A, Mak TW, Woodgett JR, Penninger JM. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 385: 350-3. PMID 9002521 DOI: 10.1038/385350a0  0.44
1996 Yeung RSM, Penninger JM, Kündig T, Khoo W, Ohashi PS, Kroemer G, Mak TW. Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: Supersensitivity to superantigen-induced septic shock European Journal of Immunology. 26: 1074-1082. PMID 8647170  0.44
1996 Pummerer CL, Luze K, Grässl G, Bachmaier K, Offner F, Burrell SK, Lenz DM, Zamborelli TJ, Penninger JM, Neu N. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. The Journal of Clinical Investigation. 97: 2057-62. PMID 8621795 DOI: 10.1172/JCI118642  0.32
1995 Wallace VA, Kawai K, Levelt CN, Kishihara K, Molina T, Timms E, Pircher H, Penninger J, Ohashi PS, Eichmann K. T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. European Journal of Immunology. 25: 1312-8. PMID 7774634 DOI: 10.1002/eji.1830250527  0.44
1995 Penninger JM, Wen T, Timms E, Potter J, Wallace VA, Matsuyama T, Ferrick D, Sydora B, Kronenberg M, Mak TW. Spontaneous resistance to acute T-cell leukaemias in TCRV gamma 1.1J gamma 4C gamma 4 transgenic mice. Nature. 375: 241-4. PMID 7746326 DOI: 10.1038/375241a0  0.44
1995 Penninger JM, Schilham MW, Timms E, Wallace VA, Mak TW. T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules. European Journal of Immunology. 25: 2115-8. PMID 7621886 DOI: 10.1002/eji.1830250748  0.44
1994 Penninger JM, Wallace VA, Timms E, Mak TW. Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells. European Journal of Immunology. 24: 1102-8. PMID 8181521 DOI: 10.1002/eji.1830240514  0.44
1993 Penninger J, Kishihara K, Molina T, Wallace VA, Timms E, Hedrick SM, Mak TW. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science (New York, N.Y.). 260: 358-61. PMID 8469988 DOI: 10.1126/science.8469988  0.44
1993 Penninger JM, Wallace VA, Kishihara K, Mak TW. The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection. Immunological Reviews. 135: 183-214. PMID 8282313 DOI: 10.1111/j.1600-065X.1993.tb00649.x  0.44
1993 Penninger JM, Neu N, Timms E, Wallace VA, Koh DR, Kishihara K, Pummerer C, Mak TW. The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. The Journal of Experimental Medicine. 178: 1837-42. PMID 8228830 DOI: 10.1084/jem.178.5.1837  0.44
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