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Josef M. Penninger - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Neuroscience Biology
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Year Citation  Score
2021 Hagelkruys A, Wirnsberger G, Stadlmann J, Wöhner M, Horrer M, Vilagos B, Jonsson G, Kogler M, Tortola L, Novatchkova M, Bönelt P, Hoffmann D, Koglgruber R, Steffen U, Schett G, ... ... Penninger JM, et al. A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans. The Journal of Experimental Medicine. 218. PMID 32930709 DOI: 10.1084/Jem.20200559  0.338
2020 Ming J, Cronin SJF, Penninger JM. Targeting the RANKL/RANK/OPG Axis for Cancer Therapy. Frontiers in Oncology. 10: 1283. PMID 32850393 DOI: 10.3389/Fonc.2020.01283  0.301
2020 Nitta T, Tsutsumi M, Nitta S, Muro R, Suzuki EC, Nakano K, Tomofuji Y, Sawa S, Okamura T, Penninger JM, Takayanagi H. Fibroblasts as a source of self-antigens for central immune tolerance. Nature Immunology. PMID 32839611 DOI: 10.1038/S41590-020-0756-8  0.379
2020 Appelberg S, Gupta S, Akusjärvi SS, Ambikan AT, Mikaeloff F, Saccon E, Végvári Á, Benfeitas R, Sperk M, Ståhlberg M, Krishnan S, Singh K, Penninger JM, Mirazimi A, Neogi U. Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells. Emerging Microbes & Infections. 1-36. PMID 32691695 DOI: 10.1080/22221751.2020.1799723  0.312
2020 Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, ... ... Penninger JM, et al. B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nature Communications. 11: 1058. PMID 32103002 DOI: 10.1038/S41467-020-14867-Z  0.307
2020 Li T, Li K, Zhang S, Wang Y, Xu Y, Cronin SJF, Sun Y, Zhang Y, Xie C, Rodriguez J, Zhou K, Hagberg H, Mallard C, Wang X, Penninger JM, et al. Overexpression of apoptosis inducing factor aggravates hypoxic-ischemic brain injury in neonatal mice. Cell Death & Disease. 11: 77. PMID 32001673 DOI: 10.1038/S41419-020-2280-Z  0.307
2019 Cronin SJF, Woolf CJ, Weiss G, Penninger JM. The Role of Iron Regulation in Immunometabolism and Immune-Related Disease. Frontiers in Molecular Biosciences. 6: 116. PMID 31824960 DOI: 10.3389/Fmolb.2019.00116  0.3
2019 Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, ... ... Penninger JM, et al. Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. PMID 31363232 DOI: 10.1038/S41586-019-1459-X  0.707
2019 Openshaw RL, Thomson DM, Thompson R, Penninger JM, Pratt JA, Morris BJ, Dawson N. Map2k7 Haploinsufficiency Induces Brain Imaging Endophenotypes and Behavioral Phenotypes Relevant to Schizophrenia. Schizophrenia Bulletin. PMID 31219577 DOI: 10.1093/Schbul/Sbz044  0.312
2019 Elling U, Woods M, Forment JV, Fu B, Yang F, Ng BL, Vicente JR, Adams DJ, Doe B, Jackson SP, Penninger JM, Balmus G. Derivation and maintenance of mouse haploid embryonic stem cells. Nature Protocols. PMID 31160788 DOI: 10.1038/S41596-019-0169-Z  0.304
2019 Rao S, Mondragón L, Pranjic B, Hanada T, Stoll G, Köcher T, Zhang P, Jais A, Lercher A, Bergthaler A, Schramek D, Haigh K, Sica V, Leduc M, Modjtahedi N, ... ... Penninger JM, et al. AIF-regulated oxidative phosphorylation supports lung cancer development. Cell Research. PMID 31133695 DOI: 10.1038/S41422-019-0181-4  0.319
2019 Mastrella G, Hou M, Li M, Stoecklein VM, Zdouc N, Volmar MNM, Miletic H, Reinhard S, Herold-Mende CC, Kleber S, Eisenhut K, Gargiulo G, Synowitz M, Vescovi AL, Harter PN, ... Penninger JM, et al. Targeting APLN/APLNR improves anti-angiogenic efficiency and blunts pro-invasive side effects of VEGFA/VEGFR2-blockade in glioblastoma. Cancer Research. PMID 30718358 DOI: 10.1158/0008-5472.Can-18-0881  0.308
2019 Lee NJ, Clarke IM, Zengin A, Enriquez RF, Nagy V, Penninger JM, Baldock PA, Herzog H. RANK deletion in NPY neurons attenuates estrogen deficiency related bone loss. Journal of Neuroendocrinology. e12687. PMID 30633834 DOI: 10.1111/Jne.12687  0.301
2019 Kälin R, Mastrella G, Hou M, Li M, Stoecklein V, Zdouc N, Volmar M, Miletic H, Reinhard S, Herold-Mende C, Kleber S, Eisenhut K, Gargiulo G, Synowitz M, Vescovi A, ... ... Penninger J, et al. ANGI-03. PHARMACOLOGICAL TARGETING OF APELIN/APLNR SIGNALING BLUNTS THERAPY RESISTANCE TO VEGFA/VEGFR2 ANTI-ANGIOGENIC TREATMENT IN GLIOBLASTOMA Neuro-Oncology. 21: vi30-vi30. DOI: 10.1093/Neuonc/Noz175.114  0.315
2019 Thell K, Urban M, Harrauer J, Haslinger I, Kuttke M, Brunner JS, Vogel A, Schabbauer G, Penninger J, Gaweco A. Master checkpoint Cbl-b inhibition: Anti-tumour efficacy in a murine colorectal cancer model following siRNA-based cell therapy Annals of Oncology. 30. DOI: 10.1093/Annonc/Mdz253.057  0.337
2018 Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, ... ... Penninger JM, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. PMID 30405245 DOI: 10.1038/S41586-018-0701-2  0.752
2018 Ikebuchi Y, Aoki S, Honma M, Hayashi M, Sugamori Y, Khan M, Kariya Y, Kato G, Tabata Y, Penninger JM, Udagawa N, Aoki K, Suzuki H. Coupling of bone resorption and formation by RANKL reverse signalling. Nature. PMID 30185903 DOI: 10.1038/S41586-018-0482-7  0.321
2018 Singh TP, Vieyra-Garcia PA, Wagner K, Penninger J, Wolf P. Cbl-b deficiency provides protection against UVB-induced skin damage by modulating inflammatory gene signature. Cell Death & Disease. 9: 835. PMID 30082827 DOI: 10.1038/S41419-018-0858-5  0.363
2018 Yamaguchi T, Suzuki T, Sato T, Takahashi A, Watanabe H, Kadowaki A, Natsui M, Inagaki H, Arakawa S, Nakaoka S, Koizumi Y, Seki S, Adachi S, Fukao A, Fujiwara T, ... ... Penninger JM, et al. The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Science Signaling. 11. PMID 29438013 DOI: 10.1126/Scisignal.Aan3638  0.321
2017 Habbeddine M, Verthuy C, Rastoin O, Chasson L, Bebien M, Bajenoff M, Adriouch S, den Haan JMM, Penninger JM, Lawrence T. Receptor Activator of NF-κB Orchestrates Activation of Antiviral Memory CD8 T Cells in the Spleen Marginal Zone. Cell Reports. 21: 2515-2527. PMID 29186688 DOI: 10.1016/J.Celrep.2017.10.111  0.356
2017 Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, et al. Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. Journal of Immunology (Baltimore, Md. : 1950). PMID 29109121 DOI: 10.4049/Jimmunol.1600396  0.409
2017 Zhang ZZ, Wang W, Jin HY, Chen X, Cheng YW, Xu YL, Song B, Penninger JM, Oudit GY, Zhong JC. Apelin Is a Negative Regulator of Angiotensin II-Mediated Adverse Myocardial Remodeling and Dysfunction. Hypertension (Dallas, Tex. : 1979). PMID 28974565 DOI: 10.1161/Hypertensionaha.117.10156  0.329
2017 Taubenschmid J, Stadlmann J, Jost M, Klokk TI, Rillahan CD, Leibbrandt A, Mechtler K, Paulson JC, Jude J, Zuber J, Sandvig K, Elling U, Marquardt T, Thiel C, Koerner C, ... Penninger JM, et al. A vital sugar code for ricin toxicity. Cell Research. PMID 28925387 DOI: 10.1038/Cr.2017.116  0.309
2017 Yamasaki T, Deki-Arima N, Kaneko A, Miyamura N, Iwatsuki M, Matsuoka M, Fujimori-Tonou N, Okamoto-Uchida Y, Hirayama J, Marth JD, Yamanashi Y, Kawasaki H, Yamanaka K, Penninger JM, Shibata S, et al. Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific Reports. 7: 7348. PMID 28779160 DOI: 10.1038/S41598-017-07845-X  0.337
2017 Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger JM, Nakashima T, Takayanagi H. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nature Immunology. PMID 28436956 DOI: 10.1038/Ni.3732  0.344
2016 Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, et al. The mevalonate pathway regulates primitive streak formation via protein farnesylation. Scientific Reports. 6: 37697. PMID 27883036 DOI: 10.1038/Srep37697  0.317
2016 Paolino M, Penninger JM. The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy. Cancers. 8. PMID 27775650 DOI: 10.3390/Cancers8100097  0.36
2016 Andritschke D, Dilling S, Emmenlauer M, Welz T, Schmich F, Misselwitz B, Rämö P, Rottner K, Kerkhoff E, Wada T, Penninger JM, Beerenwinkel N, Horvath P, Dehio C, Hardt WD. A Genome-Wide siRNA Screen Implicates Spire1/2 in SipA-Driven Salmonella Typhimurium Host Cell Invasion. Plos One. 11: e0161965. PMID 27627128 DOI: 10.1371/Journal.Pone.0161965  0.313
2016 Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H. LOX Fails to Substitute for RANKL in Osteoclastogenesis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 27606829 DOI: 10.1002/Jbmr.2990  0.371
2016 Schneider C, Nobs SP, Heer AK, Hirsch E, Penninger J, Siggs OM, Kopf M. Coincidental null mutation of Csf2rα in a colony of PI3Kγ-/- mice causes alveolar macrophage deficiency and fatal respiratory viral infection. Journal of Leukocyte Biology. PMID 27468760 DOI: 10.1189/Jlb.4Hi0316-157R  0.36
2016 Wirnsberger G, Zwolanek F, Asaoka T, Kozieradzki I, Tortola L, Wimmer RA, Kavirayani A, Fresser F, Baier G, Langdon WY, Ikeda F, Kuchler K, Penninger JM. Inhibition of CBLB protects from lethal Candida albicans sepsis. Nature Medicine. PMID 27428901 DOI: 10.1038/Nm.4134  0.337
2016 Pietrocola F, Pol J, Vacchelli E, Rao S, Enot DP, Baracco EE, Levesque S, Castoldi F, Jacquelot N, Yamazaki T, Senovilla L, Marino G, Aranda F, Durand S, Sica V, ... ... Penninger JM, et al. Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance. Cancer Cell. 30: 147-60. PMID 27411589 DOI: 10.1016/J.Ccell.2016.05.016  0.348
2016 Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, ... Penninger JM, et al. Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. The Journal of Experimental Medicine. PMID 27401343 DOI: 10.1084/Jem.20151780  0.321
2016 Tortola L, Nitsch R, Penninger JM. TNF-driven cell fate: till HACE do us part. Oncotarget. PMID 27343549 DOI: 10.18632/Oncotarget.10168  0.321
2016 Tortola L, Nitsch R, Bertrand MJ, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, ... ... Penninger JM, et al. The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate. Cell Reports. PMID 27160902 DOI: 10.1016/J.Celrep.2016.04.032  0.372
2016 Rabelo LA, Todiras M, Nunes-Souza V, Qadri F, Szijártó IA, Gollasch M, Penninger JM, Bader M, Santos RA, Alenina N. Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress. Plos One. 11: e0150255. PMID 27070147 DOI: 10.1371/Journal.Pone.0150255  0.316
2016 Luo J, Yang Z, Ma Y, Yue Z, Lin H, Qu G, Huang J, Dai W, Li C, Zheng C, Xu L, Chen H, Wang J, Li D, Siwko S, ... Penninger JM, et al. LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nature Medicine. PMID 27064449 DOI: 10.1038/Nm.4076  0.356
2015 Guerrini MM, Okamoto K, Komatsu N, Sawa S, Danks L, Penninger JM, Nakashima T, Takayanagi H. Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 43: 1174-85. PMID 26680207 DOI: 10.1016/J.Immuni.2015.10.017  0.39
2015 Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R. RANKL blockade prevents and treats aggressive osteosarcomas. Science Translational Medicine. 7: 317ra197. PMID 26659571 DOI: 10.1126/Scitranslmed.Aad0295  0.306
2015 Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, ... ... Penninger JM, et al. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528: 218-224. PMID 26659182 DOI: 10.1038/Nature15749  0.341
2015 Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S. Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife. 4. PMID 26327695 DOI: 10.7554/Elife.08467  0.334
2015 Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, ... ... Penninger JM, et al. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. PMID 26119026 DOI: 10.1016/J.Neuron.2015.06.007  0.307
2015 Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/J.Stemcr.2015.05.012  0.352
2015 Kondegowda NG, Fenutria R, Pollack IR, Orthofer M, Garcia-Ocaña A, Penninger JM, Vasavada RC. Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metabolism. 22: 77-85. PMID 26094891 DOI: 10.1016/J.Cmet.2015.05.021  0.322
2015 Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennett DG, dos Remedios CG, Haubner BJ, Penninger JM, Kühn B. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Science Translational Medicine. 7: 281ra45. PMID 25834111 DOI: 10.1126/Scitranslmed.Aaa5171  0.307
2015 Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, ... Penninger J, et al. Autophagy in malignant transformation and cancer progression. The Embo Journal. 34: 856-80. PMID 25712477 DOI: 10.15252/Embj.201490784  0.326
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Penninger JM, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/Cdd.2014.137  0.342
2014 Wenzel D, Bayerl J, Nyström A, Bruckner-Tuderman L, Meixner A, Penninger JM. Genetically corrected iPSCs as cell therapy for recessive dystrophic epidermolysis bullosa. Science Translational Medicine. 6: 264ra165. PMID 25429058 DOI: 10.1126/Scitranslmed.3010083  0.303
2014 Wirnsberger G, Zwolanek F, Stadlmann J, Tortola L, Liu SW, Perlot T, Järvinen P, Dürnberger G, Kozieradzki I, Sarao R, De Martino A, Boztug K, Mechtler K, Kuchler K, Klein C, ... ... Penninger JM, et al. Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Nature Genetics. 46: 1028-33. PMID 25129145 DOI: 10.1038/Ng.3070  0.347
2014 Boztug K, Järvinen PM, Salzer E, Racek T, Mönch S, Garncarz W, Gertz EM, Schäffer AA, Antonopoulos A, Haslam SM, Schieck L, PuchaÅ‚ka J, Diestelhorst J, Appaswamy G, Lescoeur B, ... ... Penninger JM, et al. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Nature Genetics. 46: 1021-7. PMID 25129144 DOI: 10.1038/Ng.3069  0.34
2014 Itoh T, Horiuchi M, Ikeda RH, Xu J, Bannerman P, Pleasure D, Penninger JM, Tournier C, Itoh A. ZPK/DLK and MKK4 form the critical gateway to axotomy-induced motoneuron death in neonates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10729-42. PMID 25100604 DOI: 10.1523/Jneurosci.0539-14.2014  0.314
2014 Wang W, Patel VB, Parajuli N, Fan D, Basu R, Wang Z, Ramprasath T, Kassiri Z, Penninger JM, Oudit GY. Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease. Journal of Molecular Medicine (Berlin, Germany). 92: 847-58. PMID 24728465 DOI: 10.1007/S00109-014-1149-Y  0.311
2014 Kotsinas A, Papanagnou P, Galanos P, Schramek D, Townsend P, Penninger JM, Bartek J, Gorgoulis VG. MKK7 and ARF: new players in the DNA damage response scenery. Cell Cycle (Georgetown, Tex.). 13: 1227-36. PMID 24675893 DOI: 10.4161/Cc.28654  0.302
2014 Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, ... ... Penninger JM, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 507: 508-12. PMID 24553136 DOI: 10.1038/Nature12998  0.361
2014 Qiao G, Ying H, Zhao Y, Liang Y, Guo H, Shen H, Li Z, Solway J, Tao E, Chiang YJ, Lipkowitz S, Penninger JM, Langdon WY, Zhang J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports. 6: 709-23. PMID 24508458 DOI: 10.1016/J.Celrep.2014.01.012  0.376
2014 Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, Sykacek P, Frank L, Schramek D, Komnenovic V, Sigl V, Aumayr K, Schmauss G, Fellner N, Handschuh S, ... ... Penninger JM, et al. A dual role for autophagy in a murine model of lung cancer. Nature Communications. 5: 3056. PMID 24445999 DOI: 10.1038/Ncomms4056  0.323
2014 Rao S, Yang H, Penninger JM, Kroemer G. Autophagy in non-small cell lung carcinogenesis: A positive regulator of antitumor immunosurveillance. Autophagy. 10: 529-31. PMID 24413089 DOI: 10.4161/Auto.27643  0.364
2013 Sato T, Suzuki T, Watanabe H, Kadowaki A, Fukamizu A, Liu PP, Kimura A, Ito H, Penninger JM, Imai Y, Kuba K. Apelin is a positive regulator of ACE2 in failing hearts. The Journal of Clinical Investigation. 123: 5203-11. PMID 24177423 DOI: 10.1172/Jci69608  0.338
2013 Zhang ZZ, Shang QH, Jin HY, Song B, Oudit GY, Lu L, Zhou T, Xu YL, Gao PJ, Zhu DL, Penninger JM, Zhong JC. Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice. Journal of Translational Medicine. 11: 229. PMID 24067190 DOI: 10.1186/1479-5876-11-229  0.319
2013 Song B, Jin H, Yu X, Zhang Z, Yu H, Ye J, Xu Y, Zhou T, Oudit GY, Ye JY, Chen C, Gao P, Zhu D, Penninger JM, Zhong JC. Angiotensin-converting enzyme 2 attenuates oxidative stress and VSMC proliferation via the JAK2/STAT3/SOCS3 and profilin-1/MAPK signaling pathways. Regulatory Peptides. 185: 44-51. PMID 23816468 DOI: 10.1016/J.Regpep.2013.06.007  0.328
2013 Wallner S, Lutz-Nicoladoni C, Tripp CH, Gastl G, Baier G, Penninger JM, Stoitzner P, Wolf D. The role of the e3 ligase cbl-B in murine dendritic cells. Plos One. 8: e65178. PMID 23762309 DOI: 10.1371/Journal.Pone.0065178  0.416
2013 Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (Cambridge, England). 140: 1397-401. PMID 23462470 DOI: 10.1242/Dev.088948  0.358
2013 Jux B, Staratschek-Jox A, Penninger JM, Schultze JL, Kolanus W. Vav1 regulates MHCII expression in murine resting and activated B cells. International Immunology. 25: 307-17. PMID 23391492 DOI: 10.1093/Intimm/Dxs157  0.44
2013 Badger-Brown KM, Gillis LC, Bailey ML, Penninger JM, Barber DL. CBL-B is required for leukemogenesis mediated by BCR-ABL through negative regulation of bone marrow homing. Leukemia. 27: 1146-54. PMID 23160449 DOI: 10.1038/Leu.2012.331  0.327
2013 Wöhrle FU, Halbach S, Aumann K, Schwemmers S, Braun S, Auberger P, Schramek D, Penninger JM, Laßmann S, Werner M, Waller CF, Pahl HL, Zeiser R, Daly RJ, Brummer T. Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors Leukemia. 27: 118-129. PMID 22858987 DOI: 10.1038/Leu.2012.222  0.324
2012 Desanti GE, Cowan JE, Baik S, Parnell SM, White AJ, Penninger JM, Lane PJ, Jenkinson EJ, Jenkinson WE, Anderson G. Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla. Journal of Immunology (Baltimore, Md. : 1950). 189: 5519-26. PMID 23152561 DOI: 10.4049/Jimmunol.1201815  0.404
2012 Laimer D, Dolznig H, Kollmann K, Vesely PW, Schlederer M, Merkel O, Schiefer AI, Hassler MR, Heider S, Amenitsch L, Thallinger C, Staber PB, Simonitsch-Klupp I, Artaker M, Lagger S, ... ... Penninger JM, et al. PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas. Nature Medicine. 18: 1699-704. PMID 23064464 DOI: 10.1038/Nm.2966  0.319
2012 Senovilla L, Vitale I, Martins I, Tailler M, Pailleret C, Michaud M, Galluzzi L, Adjemian S, Kepp O, Niso-Santano M, Shen S, Mariño G, Criollo A, Boilève A, Job B, ... ... Penninger JM, et al. An immunosurveillance mechanism controls cancer cell ploidy. Science (New York, N.Y.). 337: 1678-84. PMID 23019653 DOI: 10.1126/Science.1224922  0.34
2012 Hinterleitner R, Gruber T, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Tzankov A, Schuster M, Penninger JM, Loibner H, Lametschwandtner G, Wolf D, Baier G. Adoptive transfer of siRNA Cblb-silenced CD8+ T lymphocytes augments tumor vaccine efficacy in a B16 melanoma model. Plos One. 7: e44295. PMID 22962608 DOI: 10.1371/Journal.Pone.0044295  0.375
2012 Guo H, Qiao G, Ying H, Li Z, Zhao Y, Liang Y, Yang L, Lipkowitz S, Penninger JM, Langdon WY, Zhang J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity. Cell Reports. 1: 472-82. PMID 22763434 DOI: 10.1016/J.Celrep.2012.04.008  0.395
2012 Jin HY, Song B, Oudit GY, Davidge ST, Yu HM, Jiang YY, Gao PJ, Zhu DL, Ning G, Kassiri Z, Penninger JM, Zhong JC. ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production. Plos One. 7: e38502. PMID 22693641 DOI: 10.1371/Journal.Pone.0038502  0.33
2012 Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Sato M, Penninger JM, Yasuda H, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N. Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice Proceedings of the National Academy of Sciences of the United States of America. 109: 10006-10011. PMID 22670054 DOI: 10.1073/Pnas.1207361109  0.325
2012 Arai A, Mizoguchi T, Harada S, Kobayashi Y, Nakamichi Y, Yasuda H, Penninger JM, Yamada K, Udagawa N, Takahashi N. Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment. Journal of Cell Science. 125: 2910-7. PMID 22454522 DOI: 10.1242/Jcs.099986  0.356
2012 Roberts NA, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, Withers DR, McConnell FM, Desanti GE, Benezech C, Parnell SM, Cunningham AF, Paolino M, Penninger JM, Simon AK, Nitta T, et al. Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium. Immunity. 36: 427-37. PMID 22425250 DOI: 10.1016/J.Immuni.2012.01.016  0.374
2012 Liu Z, Huang XR, Chen HY, Penninger JM, Lan HY. Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy. Laboratory Investigation; a Journal of Technical Methods and Pathology. 92: 650-61. PMID 22330342 DOI: 10.1038/Labinvest.2012.2  0.308
2012 Perlot T, Penninger JM. Development and function of murine B cells lacking RANK. Journal of Immunology (Baltimore, Md. : 1950). 188: 1201-5. PMID 22219325 DOI: 10.4049/Jimmunol.1102063  0.393
2012 Douni E, Rinotas V, Makrinou E, Zwerina J, Penninger JM, Eliopoulos E, Schett G, Kollias G. A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Human Molecular Genetics. 21: 784-98. PMID 22068587 DOI: 10.1093/Hmg/Ddr510  0.333
2012 Lutz-Nicoladoni C, Wallner S, Stoitzner P, Pircher M, Gruber T, Wolf AM, Gastl G, Penninger JM, Baier G, Wolf D. Reinforcement of cancer immunotherapy by adoptive transfer of cblb-deficient CD8+ T cells combined with a DC vaccine. Immunology and Cell Biology. 90: 130-4. PMID 21383769 DOI: 10.1038/Icb.2011.11  0.38
2012 Grabner B, Schramek D, Mueller KM, Zwick RH, Penninger J, Poli V, Moriggl R, Sibilia M, Popper H, Eferl R, Casanova E. Abstract 4880: Disruption of STAT3 signaling promotes K-Ras induced lung tumorigenesis Cancer Research. 72: 4880-4880. DOI: 10.1158/1538-7445.Am2012-4880  0.307
2011 Yamasaki T, Kawasaki H, Arakawa S, Shimizu K, Shimizu S, Reiner O, Okano H, Nishina S, Azuma N, Penninger JM, Katada T, Nishina H. Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16872-83. PMID 22090513 DOI: 10.1523/Jneurosci.1111-11.2011  0.326
2011 Miyamoto K, Yoshida S, Kawasumi M, Hashimoto K, Kimura T, Sato Y, Kobayashi T, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Hao W, Morioka H, Chiba K, Kobayashi T, ... ... Penninger JM, et al. Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. The Journal of Experimental Medicine. 208: 2175-81. PMID 22006978 DOI: 10.1084/Jem.20101890  0.341
2011 Lee AW, Mao Y, Penninger JM, Yu S. Gab2 promotes colony-stimulating factor 1-regulated macrophage expansion via alternate effectors at different stages of development. Molecular and Cellular Biology. 31: 4563-81. PMID 21930791 DOI: 10.1128/Mcb.05706-11  0.341
2011 Muto A, Mizoguchi T, Udagawa N, Ito S, Kawahara I, Abiko Y, Arai A, Harada S, Kobayashi Y, Nakamichi Y, Penninger JM, Noguchi T, Takahashi N. Lineage-committed osteoclast precursors circulate in blood and settle down into bone. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 2978-90. PMID 21898588 DOI: 10.1002/Jbmr.490  0.337
2011 Koletar MM, Cheng HY, Penninger JM, Ralph MR. Loss of dexras1 alters nonphotic circadian phase shifts and reveals a role for the intergeniculate leaflet (IGL) in gene-targeted mice. Chronobiology International. 28: 553-62. PMID 21834641 DOI: 10.3109/07420528.2011.592235  0.658
2011 Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G. Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells. Journal of Autoimmunity. 37: 198-208. PMID 21700422 DOI: 10.1016/J.Jaut.2011.05.018  0.414
2011 Hanada R, Hanada T, Sigl V, Schramek D, Penninger JM. RANKL/RANK-beyond bones Journal of Molecular Medicine. 89: 647-656. PMID 21445556 DOI: 10.1007/S00109-011-0749-Z  0.318
2011 Mouri Y, Yano M, Shinzawa M, Shimo Y, Hirota F, Nishikawa Y, Nii T, Kiyonari H, Abe T, Uehara H, Izumi K, Tamada K, Chen L, Penninger JM, Inoue J, et al. Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma. Journal of Immunology (Baltimore, Md. : 1950). 186: 5047-57. PMID 21441458 DOI: 10.4049/Jimmunol.1003533  0.377
2011 Duheron V, Hess E, Duval M, Decossas M, Castaneda B, Klöpper JE, Amoasii L, Barbaroux JB, Williams IR, Yagita H, Penninger J, Choi Y, Lézot F, Groves R, Paus R, et al. Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unit. Proceedings of the National Academy of Sciences of the United States of America. 108: 5342-7. PMID 21402940 DOI: 10.1073/Pnas.1013054108  0.347
2011 Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, Guo D, Holland SM, Scholey JW, Penninger JM, Kassiri Z, Oudit GY. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovascular Research. 91: 151-61. PMID 21285291 DOI: 10.1093/Cvr/Cvr036  0.305
2011 Paolino M, Thien CB, Gruber T, Hinterleitner R, Baier G, Langdon WY, Penninger JM. Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions. Journal of Immunology (Baltimore, Md. : 1950). 186: 2138-47. PMID 21248250 DOI: 10.4049/Jimmunol.1003390  0.396
2011 Meng X, Arocena M, Penninger J, Gage FH, Zhao M, Song B. PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Experimental Neurology. 227: 210-7. PMID 21092738 DOI: 10.1016/J.Expneurol.2010.11.002  0.306
2011 Zhong JC, Ye JY, Jin HY, Yu X, Yu HM, Zhu DL, Gao PJ, Huang DY, Shuster M, Loibner H, Guo JM, Yu XY, Xiao BX, Gong ZH, Penninger JM, et al. Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regulatory Peptides. 166: 90-7. PMID 20854846 DOI: 10.1016/J.Regpep.2010.09.005  0.325
2011 Oh SY, Park JU, Zheng T, Kim YK, Wu F, Cho SH, Barber D, Penninger J, Zhu Z. Cbl-b regulates airway mucosal tolerance to aeroallergen. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 41: 434-42. PMID 20738317 DOI: 10.1111/J.1365-2222.2010.03593.X  0.386
2011 Kenner L, Laimer D, Dolznig H, Vesely P, Kollmann K, Schiefer AI, Sexl V, Staber PB, Hoefler G, Penninger J, Inghirami G, Ulrich J. New and Highly Efficient Therapy for Treatment NPM-ALK Associated Lymphomas Blood. 118: 1659-1659. DOI: 10.1182/Blood.V118.21.1659.1659  0.305
2010 Zhao M, Penninger J, Isseroff RR. Electrical Activation of Wound-Healing Pathways. Advances in Skin & Wound Care. 1: 567-573. PMID 22025904 DOI: 10.1089/9781934854013.567  0.303
2010 Hanada R, Hanada T, Penninger JM. Physiology and pathophysiology of the RANKL/RANK system Biological Chemistry. 391: 1365-1370. PMID 21087090 DOI: 10.1515/Bc.2010.149  0.306
2010 del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takakura N, Fukamizu A, Penninger J, Eichmann A. Identification and functional analysis of endothelial tip cell-enriched genes. Blood. 116: 4025-33. PMID 20705756 DOI: 10.1182/Blood-2010-02-270819  0.366
2010 Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, et al. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. The Journal of Clinical Investigation. 120: 3310-25. PMID 20697156 DOI: 10.1172/Jci42391  0.312
2010 Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H, Furutani-Seiki M, Penninger JM, Katada T, Nishina H. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. Journal of Cellular Biochemistry. 110: 1022-37. PMID 20564202 DOI: 10.1002/Jcb.22616  0.348
2010 Paolino M, Penninger JM. Cbl-b in T-cell activation Seminars in Immunopathology. 32: 137-148. PMID 20458601 DOI: 10.1007/S00281-010-0197-9  0.413
2010 Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, ... ... Penninger JM, et al. A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function. Cell. 141: 142-53. PMID 20371351 DOI: 10.1016/J.Cell.2010.02.023  0.301
2010 Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño JE, Baba HA, Abramowitz J, Birnbaumer L, Penninger JM, Pongs O, et al. Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Research in Cardiology. 105: 583-95. PMID 20352235 DOI: 10.1007/S00395-010-0098-Z  0.308
2010 Meixner A, Karreth F, Kenner L, Penninger JM, Wagner EF. Jun and JunD-dependent functions in cell proliferation and stress response. Cell Death and Differentiation. 17: 1409-19. PMID 20300111 DOI: 10.1038/Cdd.2010.22  0.301
2010 Haubner BJ, Neely GG, Voelkl JG, Damilano F, Kuba K, Imai Y, Komnenovic V, Mayr A, Pachinger O, Hirsch E, Penninger JM, Metzler B. PI3Kgamma protects from myocardial ischemia and reperfusion injury through a kinase-independent pathway. Plos One. 5: e9350. PMID 20179753 DOI: 10.1371/Journal.Pone.0009350  0.304
2010 Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, ... ... Penninger JM, et al. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell. 140: 148-60. PMID 20074523 DOI: 10.1016/J.Cell.2009.12.027  0.323
2010 Xu H, Su Z, Wu J, Yang M, Penninger JM, Martin CM, Kvietys PR, Rui T. The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway. Journal of Immunology (Baltimore, Md. : 1950). 184: 1492-8. PMID 20028656 DOI: 10.4049/Jimmunol.0902660  0.303
2010 Leibbrandt A, Penninger JM. Novel functions of RANK(L) signaling in the immune system Advances in Experimental Medicine and Biology. 658: 77-94. PMID 19950018 DOI: 10.1007/978-1-4419-1050-9_9  0.381
2010 Lutz-Nicoladoni C, Stoizner P, Pircher M, Wallner S, Wolf AM, Gastl G, Penninger J, Baier G, Wolf D. Reinforcement of Cancer Immunotherapy by Adoptive Transfer of Cblb-Deficient Cytotoxic T Lymphocytes Combined with a Dendritic Cell Vaccine Blood. 116: 957-957. DOI: 10.1182/Blood.V116.21.957.957  0.366
2009 Hanada R, Leibbrandt A, Hanada T, Kitaoka S, Furuyashiki T, Fujihara H, Trichereau J, Paolino M, Qadri F, Plehm R, Klaere S, Komnenovic V, Mimata H, Yoshimatsu H, Takahashi N, ... ... Penninger JM, et al. Central control of fever and female body temperature by RANKL/RANK. Nature. 462: 505-9. PMID 19940926 DOI: 10.1038/Nature08596  0.345
2009 Nagatake T, Fukuyama S, Kim DY, Goda K, Igarashi O, Sato S, Nochi T, Sagara H, Yokota Y, Jetten AM, Kaisho T, Akira S, Mimuro H, Sasakawa C, Fukui Y, ... ... Penninger JM, et al. Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity. The Journal of Experimental Medicine. 206: 2351-64. PMID 19822644 DOI: 10.1084/Jem.20091436  0.326
2009 Blyszczuk P, Kania G, Dieterle T, Marty RR, Valaperti A, Berthonneche C, Pedrazzini T, Berger CT, Dirnhofer S, Matter CM, Penninger JM, Lüscher TF, Eriksson U. Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. Circulation Research. 105: 912-20. PMID 19762681 DOI: 10.1161/Circresaha.109.199802  0.346
2009 Leibbrandt A, Penninger JM. RANK(L) as a key target for controlling bone loss Advances in Experimental Medicine and Biology. 647: 130-145. PMID 19760071 DOI: 10.1007/978-0-387-89520-8_9  0.304
2009 Hayer S, Pundt N, Peters MA, Wunrau C, Kühnel I, Neugebauer K, Strietholt S, Zwerina J, Korb A, Penninger J, Joosten LA, Gay S, Rückle T, Schett G, Pap T. PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 4288-98. PMID 19734303 DOI: 10.1096/Fj.09-135160  0.327
2009 Leibbrandt A, Penninger JM. RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies Advances in Experimental Medicine and Biology. 649: 100-113. PMID 19731623 DOI: 10.1007/978-1-4419-0298-6_7  0.31
2009 Joza N, Pospisilik JA, Hangen E, Hanada T, Modjtahedi N, Penninger JM, Kroemer G. AIF: Not just an apoptosis-inducing factor Annals of the New York Academy of Sciences. 1171: 2-11. PMID 19723031 DOI: 10.1111/J.1749-6632.2009.04681.X  0.308
2009 Paolino M, Penninger JM. E3 ubiquitin ligases in T-cell tolerance European Journal of Immunology. 39: 2337-2344. PMID 19714573 DOI: 10.1002/Eji.200939662  0.383
2009 Osterreicher CH, Taura K, De Minicis S, Seki E, Penz-Osterreicher M, Kodama Y, Kluwe J, Schuster M, Oudit GY, Penninger JM, Brenner DA. Angiotensin-converting-enzyme 2 inhibits liver fibrosis in mice. Hepatology (Baltimore, Md.). 50: 929-38. PMID 19650157 DOI: 10.1002/Hep.23104  0.303
2009 Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G. PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation. Science Signaling. 2: ra30. PMID 19549985 DOI: 10.1126/Scisignal.2000046  0.412
2009 Cronin SJF, Nehme NT, Limmer S, Liegeois S, Pospisilik JA, Schramek D, Leibbrandt A, De Simoes RM, Gruber S, Puc U, Ebersberger I, Zoranovic T, Neely GG, Von Haeseler A, Ferrandon D, ... Penninger JM, et al. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection Science. 325: 340-343. PMID 19520911 DOI: 10.1126/Science.1173164  0.3
2009 Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, ... ... Penninger J, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/Cdd.2009.44  0.317
2009 Mizoguchi T, Muto A, Udagawa N, Arai A, Yamashita T, Hosoya A, Ninomiya T, Nakamura H, Yamamoto Y, Kinugawa S, Nakamura M, Nakamichi Y, Kobayashi Y, Nagasawa S, Oda K, ... ... Penninger JM, et al. Identification of cell cycle-arrested quiescent osteoclast precursors in vivo. The Journal of Cell Biology. 184: 541-54. PMID 19237598 DOI: 10.1083/Jcb.200806139  0.351
2009 Oudit GY, Penninger JM. Cardiac regulation by phosphoinositide 3-kinases and PTEN Cardiovascular Research. 82: 250-260. PMID 19147653 DOI: 10.1093/Cvr/Cvp014  0.364
2009 Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H. Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway. Journal of Biochemistry. 145: 345-54. PMID 19106158 DOI: 10.1093/Jb/Mvn172  0.36
2008 Leibbrandt A, Penninger JM. RANK/RANKL: Regulators of immune responses and bone physiology Annals of the New York Academy of Sciences. 1143: 123-150. PMID 19076348 DOI: 10.1196/Annals.1443.016  0.321
2008 Raberger J, Boucheron N, Sakaguchi S, Penninger JM, Ellmeier W. Impaired T-cell development in the absence of Vav1 and Itk European Journal of Immunology. 38: 3530-3542. PMID 19009524 DOI: 10.1002/Eji.200838388  0.418
2008 Hikosaka Y, Nitta T, Ohigashi I, Yano K, Ishimaru N, Hayashi Y, Matsumoto M, Matsuo K, Penninger JM, Takayanagi H, Yokota Y, Yamada H, Yoshikai Y, Inoue Ji, Akiyama T, et al. The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator Immunity. 29: 438-450. PMID 18799150 DOI: 10.1016/J.Immuni.2008.06.018  0.33
2008 Akiyama T, Shimo Y, Yanai H, Qin J, Ohshima D, Maruyama Y, Asaumi Y, Kitazawa J, Takayanagi H, Penninger JM, Matsumoto M, Nitta T, Takahama Y, Inoue J. The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance. Immunity. 29: 423-37. PMID 18799149 DOI: 10.1016/J.Immuni.2008.06.015  0.371
2008 Ban K, Cooper AJ, Samuel S, Bhatti A, Patel M, Izumo S, Penninger JM, Backx PH, Oudit GY, Tsushima RG. Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning. Circulation Research. 103: 643-53. PMID 18688045 DOI: 10.1161/Circresaha.108.175018  0.334
2008 Lovren F, Pan Y, Quan A, Teoh H, Wang G, Shukla PC, Levitt KS, Oudit GY, Al-Omran M, Stewart DJ, Slutsky AS, Peterson MD, Backx PH, Penninger JM, Verma S. Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis. American Journal of Physiology. Heart and Circulatory Physiology. 295: H1377-84. PMID 18660448 DOI: 10.1152/Ajpheart.00331.2008  0.317
2008 Meixner A, Zenz R, Schonthaler HB, Kenner L, Scheuch H, Penninger JM, Wagner EF. Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nature Cell Biology. 10: 1003-11. PMID 18641637 DOI: 10.1038/Ncb1761  0.303
2008 Chavakis E, Carmona G, Urbich C, Göttig S, Henschler R, Penninger JM, Zeiher AM, Chavakis T, Dimmeler S. Phosphatidylinositol-3-kinase-gamma is integral to homing functions of progenitor cells. Circulation Research. 102: 942-9. PMID 18323525 DOI: 10.1161/Circresaha.107.164376  0.401
2008 Joza N, Galindo K, Pospisilik JA, Benit P, Rangachari M, Kanitz EE, Nakashima Y, Neely GG, Rustin P, Abrams JM, Kroemer G, Penninger JM. The molecular archaeology of a mitochondrial death effector: AIF in Drosophila Cell Death and Differentiation. 15: 1009-1018. PMID 18309327 DOI: 10.1038/Cdd.2008.24  0.321
2008 Galluzzi L, Joza N, Tasdemir E, Maiuri MC, Hengartner M, Abrams JM, Tavernarakis N, Penninger J, Madeo F, Kroemer G. No death without life: vital functions of apoptotic effectors. Cell Death and Differentiation. 15: 1113-23. PMID 18309324 DOI: 10.1038/Cdd.2008.28  0.309
2008 Qiao G, Li Z, Molinero L, Alegre ML, Ying H, Sun Z, Penninger JM, Zhang J. T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b. Molecular and Cellular Biology. 28: 2470-80. PMID 18227156 DOI: 10.1128/Mcb.01505-07  0.395
2008 Cronin SJ, Penninger JM. From T-cell activation signals to signaling control of anti-cancer immunity. Immunological Reviews. 220: 151-68. PMID 17979845 DOI: 10.1111/J.1600-065X.2007.00570.X  0.391
2008 Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death and Differentiation. 15: 89-93. PMID 17762881 DOI: 10.1038/Sj.Cdd.4402222  0.349
2008 Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T. Cell type-specific regulation of ITAM-mediated NF-κB activation by the adaptors, CARMA1 and CARD9 Journal of Immunology. 181: 918-930. DOI: 10.4049/Jimmunol.181.2.918  0.399
2007 Kuwana H, Terada Y, Kobayashi T, Okado T, Penninger JM, Irie-Sasaki J, Sasaki T, Sasaki S. The phosphoinositide-3 kinase gamma-Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity. Kidney International. 73: 430-45. PMID 18046317 DOI: 10.1038/Sj.Ki.5002702  0.329
2007 Tassi I, Cella M, Gilfillan S, Turnbull I, Diacovo TG, Penninger JM, Colonna M. p110gamma and p110delta phosphoinositide 3-kinase signaling pathways synergize to control development and functions of murine NK cells. Immunity. 27: 214-27. PMID 17723215 DOI: 10.1016/J.Immuni.2007.07.014  0.394
2007 Loeser S, Penninger JM. The ubiquitin E3 ligase Cbl-b in T cells tolerance and tumor immunity. Cell Cycle (Georgetown, Tex.). 6: 2478-85. PMID 17704644 DOI: 10.4161/Cc.6.20.4797  0.388
2007 Kuba K, Zhang L, Imai Y, Arab S, Chen M, Maekawa Y, Leschnik M, Leibbrandt A, Markovic M, Makovic M, Schwaighofer J, Beetz N, Musialek R, Neely GG, Komnenovic V, ... ... Penninger JM, et al. Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circulation Research. 101: e32-42. PMID 17673668 DOI: 10.1161/Circresaha.107.158659  0.321
2007 Rossi SW, Kim MY, Leibbrandt A, Parnell SM, Jenkinson WE, Glanville SH, McConnell FM, Scott HS, Penninger JM, Jenkinson EJ, Lane PJ, Anderson G. RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla. The Journal of Experimental Medicine. 204: 1267-72. PMID 17502664 DOI: 10.1084/Jem.20062497  0.381
2007 Oudit GY, Kassiri Z, Patel MP, Chappell M, Butany J, Backx PH, Tsushima RG, Scholey JW, Khokha R, Penninger JM. Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice. Cardiovascular Research. 75: 29-39. PMID 17499227 DOI: 10.1016/J.Cardiores.2007.04.007  0.319
2007 Liu L, Puri KD, Penninger JM, Kubes P. Leukocyte PI3Kgamma and PI3Kdelta have temporally distinct roles for leukocyte recruitment in vivo. Blood. 110: 1191-8. PMID 17488877 DOI: 10.1182/Blood-2006-11-060103  0.371
2007 Hara H, Ishihara C, Takeuchi A, Imanishi T, Xue L, Morris SW, Inui M, Takai T, Shibuya A, Saijo S, Iwakura Y, Ohno N, Koseki H, Yoshida H, Penninger JM, et al. The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors. Nature Immunology. 8: 619-29. PMID 17486093 DOI: 10.1038/Ni1466  0.401
2007 Zuber AM, Singer D, Penninger JM, Rossier BC, Firsov D. Increased renal responsiveness to vasopressin and enhanced V2 receptor signaling in RGS2-/- mice. Journal of the American Society of Nephrology : Jasn. 18: 1672-8. PMID 17475820 DOI: 10.1681/Asn.2007010032  0.351
2007 Loeser S, Loser K, Bijker MS, Rangachari M, van der Burg SH, Wada T, Beissert S, Melief CJ, Penninger JM. Spontaneous tumor rejection by cbl-b-deficient CD8+ T cells. The Journal of Experimental Medicine. 204: 879-91. PMID 17403934 DOI: 10.1084/Jem.20061699  0.738
2007 Loeser S, Penninger JM. Regulation of peripheral T cell tolerance by the E3 ubiquitin ligase Cbl-b. Seminars in Immunology. 19: 206-14. PMID 17391982 DOI: 10.1016/J.Smim.2007.02.004  0.381
2007 Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger J, Lin X. Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. The Embo Journal. 26: 1794-805. PMID 17363905 DOI: 10.1038/Sj.Emboj.7601622  0.33
2007 Séverin S, Gratacap MP, Lenain N, Alvarez L, Hollande E, Penninger JM, Gachet C, Plantavid M, Payrastre B. Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. The Journal of Clinical Investigation. 117: 944-52. PMID 17347685 DOI: 10.1172/Jci29967  0.329
2007 Nakamichi Y, Udagawa N, Kobayashi Y, Nakamura M, Yamamoto Y, Yamashita T, Mizoguchi T, Sato M, Mogi M, Penninger JM, Takahashi N. Osteoprotegerin reduces the serum level of receptor activator of NF-kappaB ligand derived from osteoblasts. Journal of Immunology (Baltimore, Md. : 1950). 178: 192-200. PMID 17182555 DOI: 10.4049/Jimmunol.178.1.192  0.35
2007 Badger-Brown KM, Bailey ML, Penninger J, Barber DL. Cbl-b Deficiency Enhances Motility and Impairs Leukemogenesis by Bcr-Abl. Blood. 110: 1019-1019. DOI: 10.1182/Blood.V110.11.1019.1019  0.356
2006 Cheng HY, Dziema H, Papp J, Mathur DP, Koletar M, Ralph MR, Penninger JM, Obrietan K. The molecular gatekeeper Dexras1 sculpts the photic responsiveness of the mammalian circadian clock. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12984-95. PMID 17167088 DOI: 10.1523/Jneurosci.4253-06.2006  0.767
2006 Loser K, Mehling A, Loeser S, Apelt J, Kuhn A, Grabbe S, Schwarz T, Penninger JM, Beissert S. Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nature Medicine. 12: 1372-9. PMID 17143276 DOI: 10.1038/Nm1518  0.372
2006 Kuba K, Imai Y, Rao S, Jiang C, Penninger JM. Lessons from SARS: control of acute lung failure by the SARS receptor ACE2. Journal of Molecular Medicine (Berlin, Germany). 84: 814-20. PMID 16988814 DOI: 10.1007/S00109-006-0094-9  0.308
2006 Maruyama K, Takada Y, Ray N, Kishimoto Y, Penninger JM, Yasuda H, Matsuo K. Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 3799-805. PMID 16951341 DOI: 10.4049/Jimmunol.177.6.3799  0.342
2006 Roy AA, Nunn C, Ming H, Zou MX, Penninger J, Kirshenbaum LA, Dixon SJ, Chidiac P. Up-regulation of endogenous RGS2 mediates cross-desensitization between Gs and Gq signaling in osteoblasts. The Journal of Biological Chemistry. 281: 32684-93. PMID 16950788 DOI: 10.1074/Jbc.M604416200  0.356
2006 Alnaeeli M, Penninger JM, Teng YT. Immune interactions with CD4+ T cells promote the development of functional osteoclasts from murine CD11c+ dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 3314-26. PMID 16920972 DOI: 10.4049/Jimmunol.177.5.3314  0.387
2006 Rangachari M, Mauermann N, Marty RR, Dirnhofer S, Kurrer MO, Komnenovic V, Penninger JM, Eriksson U. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. The Journal of Experimental Medicine. 203: 2009-19. PMID 16880257 DOI: 10.1084/Jem.20052222  0.722
2006 Brown D, Yu BD, Joza N, Bénit P, Meneses J, Firpo M, Rustin P, Penninger JM, Martin GR. Loss of Aif function causes cell death in the mouse embryo, but the temporal progression of patterning is normal. Proceedings of the National Academy of Sciences of the United States of America. 103: 9918-23. PMID 16788063 DOI: 10.1073/Pnas.0603950103  0.316
2006 Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. The American Journal of Pathology. 168: 1808-20. PMID 16723697 DOI: 10.2353/Ajpath.2006.051091  0.33
2006 Yamamoto Y, Udagawa N, Matsuura S, Nakamichi Y, Horiuchi H, Hosoya A, Nakamura M, Ozawa H, Takaoka K, Penninger JM, Noguchi T, Takahashi N. Osteoblasts provide a suitable microenvironment for the action of receptor activator of nuclear factor-kappaB ligand. Endocrinology. 147: 3366-74. PMID 16627581 DOI: 10.1210/En.2006-0216  0.34
2006 Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, ... ... Penninger JM, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440: 692-6. PMID 16572175 DOI: 10.1038/Nature04524  0.318
2006 Danilczyk U, Penninger JM. Angiotensin-converting enzyme II in the heart and the kidney. Circulation Research. 98: 463-71. PMID 16514079 DOI: 10.1161/01.Res.0000205761.22353.5F  0.304
2006 Kim NS, Kim HJ, Koo BK, Kwon MC, Kim YW, Cho Y, Yokota Y, Penninger JM, Kong YY. Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2. Molecular and Cellular Biology. 26: 1002-13. PMID 16428453 DOI: 10.1128/Mcb.26.3.1002-1013.2006  0.402
2006 Marty RR, Dirnhofer S, Mauermann N, Schweikert S, Akira S, Hunziker L, Penninger JM, Eriksson U. MyD88 signaling controls autoimmune myocarditis induction. Circulation. 113: 258-65. PMID 16401773 DOI: 10.1161/Circulationaha.105.564294  0.409
2006 Atfield AD, Liu P, Penninger JM. The Biochemical Mechanisms of T-Cell Anergy Current Immunology Reviews. 2: 73-99. DOI: 10.2174/157339506775471875  0.389
2005 Wada T, Nakashima T, Hiroshi N, Penninger JM. RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends in Molecular Medicine. 12: 17-25. PMID 16356770 DOI: 10.1016/J.Molmed.2005.11.007  0.3
2005 Bachmaier K, Penninger JM. Chlamydia and antigenic mimicry. Current Topics in Microbiology and Immunology. 296: 153-163. PMID 16323424 DOI: 10.1007/3-540-30791-5_9  0.301
2005 Wang X, Zeng W, Soyombo AA, Tang W, Ross EM, Barnes AP, Milgram SL, Penninger JM, Allen PB, Greengard P, Muallem S. Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors. Nature Cell Biology. 7: 405-11. PMID 15793568 DOI: 10.1038/Ncb1237  0.314
2005 Puri KD, Doggett TA, Huang CY, Douangpanya J, Hayflick JS, Turner M, Penninger J, Diacovo TG. The role of endothelial PI3Kγ activity in neutrophil trafficking Blood. 106: 150-157. PMID 15769890 DOI: 10.1182/Blood-2005-01-0023  0.382
2005 Sasaki J, Sasaki T, Yamazaki M, Matsuoka K, Taya C, Shitara H, Takasuga S, Nishio M, Mizuno K, Wada T, Miyazaki H, Watanabe H, Iizuka R, Kubo S, Murata S, ... ... Penninger JM, et al. Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. The Journal of Experimental Medicine. 201: 859-70. PMID 15767368 DOI: 10.1084/Jem.20041891  0.399
2005 Wada T, Nakashima T, Oliveira-dos-Santos AJ, Gasser J, Hara H, Schett G, Penninger JM. The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nature Medicine. 11: 394-9. PMID 15750601 DOI: 10.1038/Nm1203  0.305
2005 Krawczyk CM, Jones RG, Atfteld A, Bachmaier K, Arya S, Odermatt B, Ohashi PS, Penninger JM. Differential control of CD28-regulated in vivo immunity by the E3 ligase Cbl-b Journal of Immunology. 174: 1472-1478. PMID 15661906 DOI: 10.4049/Jimmunol.174.3.1472  0.695
2005 Wilson LD, Ross SA, Lepore DA, Wada T, Penninger JM, Thomas PQ. Developmentally regulated expression of the regulator of G-protein signaling gene 2 (Rgs2) in the embryonic mouse pituitary. Gene Expression Patterns : Gep. 5: 305-11. PMID 15661635 DOI: 10.1016/J.Modgep.2004.10.005  0.361
2005 Ricci R, Eriksson U, Oudit GY, Eferl R, Akhmedov A, Sumara I, Sumara G, Kassiri Z, David JP, Bakiri L, Sasse B, Idarraga MH, Rath M, Kurz D, Theussl HC, ... ... Penninger JM, et al. Distinct functions of junD in cardiac hypertrophy and heart failure. Genes & Development. 19: 208-13. PMID 15655111 DOI: 10.1101/Gad.327005  0.314
2005 Fischer L, Lugea A, Shahsahebi M, Penninger JM, Vanhaesebroeck B, Friess H, Gukovskaya AS, Pandol SJ, Gukovsky I. CLASS I PI3K ISOFORMS ?? AND ?? REGULATE KEY RESPONSES OF CERULEIN-INDUCED PANCREATITIS. PI3K?? IS NECESSARY FOR TRYPSIN ACTIVATION Pancreas. 31: 441. DOI: 10.1097/01.Mpa.0000193668.40020.3C  0.307
2004 Vahsen N, Candé C, Brière JJ, Bénit P, Joza N, Larochette N, Mastroberardino PG, Pequignot MO, Casares N, Lazar V, Feraud O, Debili N, Wissing S, Engelhardt S, Madeo F, ... ... Penninger JM, et al. AIF deficiency compromises oxidative phosphorylation. The Embo Journal. 23: 4679-89. PMID 15526035 DOI: 10.1038/Sj.Emboj.7600461  0.323
2004 Martin-McCaffrey L, Willard FS, Oliveira-dos-Santos AJ, Natale DR, Snow BE, Kimple RJ, Pajak A, Watson AJ, Dagnino L, Penninger JM, Siderovski DP, D'Souza SJ. RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Developmental Cell. 7: 763-9. PMID 15525537 DOI: 10.1016/J.Devcel.2004.10.004  0.329
2004 Hara H, Bakal C, Wada T, Bouchard D, Rottapel R, Saito T, Penninger JM. The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse. The Journal of Experimental Medicine. 200: 1167-77. PMID 15520247 DOI: 10.1084/Jem.20032246  0.397
2004 Matsumoto G, Kubota E, Omi Y, Lee U, Penninger JM. Essential role of LFA-1 in activating Th2-like responses by alpha-galactosylceramide-activated NKT cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 4976-84. PMID 15470040 DOI: 10.4049/Jimmunol.173.8.4976  0.32
2004 Gronski MA, Boulter JM, Moskophidis D, Nguyen LT, Holmberg K, Elford AR, Deenick EK, Kim HO, Penninger JM, Odermatt B, Gallimore A, Gascoigne NR, Ohashi PS. TCR affinity and negative regulation limit autoimmunity. Nature Medicine. 10: 1234-9. PMID 15467726 DOI: 10.1038/Nm1114  0.382
2004 Cheng HY, Obrietan K, Cain SW, Lee BY, Agostino PV, Joza NA, Harrington ME, Ralph MR, Penninger JM. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron. 43: 715-28. PMID 15339652 DOI: 10.1016/J.Neuron.2004.08.021  0.743
2004 Jeon MS, Atfield A, Venuprasad K, Krawczyk C, Sarao R, Elly C, Yang C, Arya S, Bachmaier K, Su L, Bouchard D, Jones R, Gronski M, Ohashi P, Wada T, ... ... Penninger JM, et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction Immunity. 21: 167-177. PMID 15308098 DOI: 10.1016/J.Immuni.2004.07.013  0.7
2004 Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. Journal of Molecular and Cellular Cardiology. 37: 449-71. PMID 15276015 DOI: 10.1016/J.Yjmcc.2004.05.015  0.368
2004 Rangachari M, Penninger JM. Negative regulation of T cell receptor signals. Current Opinion in Pharmacology. 4: 415-22. PMID 15251138 DOI: 10.1016/J.Coph.2004.03.007  0.749
2004 Cheng HY, Laviolette SR, van der Kooy D, Penninger JM. DREAM ablation selectively alters THC place aversion and analgesia but leaves intact the motivational and analgesic effects of morphine. The European Journal of Neuroscience. 19: 3033-41. PMID 15182311 DOI: 10.1111/J.0953-816X.2004.03435.X  0.644
2004 Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene. 23: 2838-49. PMID 15077147 DOI: 10.1038/Sj.Onc.1207556  0.344
2004 Wada T, Joza N, Cheng HY, Sasaki T, Kozieradzki I, Bachmaier K, Katada T, Schreiber M, Wagner EF, Nishina H, Penninger JM. MKK7 couples stress signalling to G2/M cell-cycle progression and cellular senescence. Nature Cell Biology. 6: 215-26. PMID 15039780 DOI: 10.1038/Ncb1098  0.683
2004 Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Fischer L, Penninger JM, Pandol SJ, Gukovskaya AS. Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology. 126: 554-66. PMID 14762792 DOI: 10.1053/J.Gastro.2003.11.017  0.331
2004 Candé C, Vahsen N, Kouranti I, Schmitt E, Daugas E, Spahr C, Luban J, Kroemer RT, Giordanetto F, Garrido C, Penninger JM, Kroemer G. AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis Oncogene. 23: 1514-1521. PMID 14716299 DOI: 10.1038/Sj.Onc.1207279  0.307
2004 Marra LE, Zhang ZX, Joe B, Campbell J, Levy GA, Penninger J, Zhang L. IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. Journal of Immunology (Baltimore, Md. : 1950). 172: 1028-35. PMID 14707076 DOI: 10.4049/Jimmunol.172.2.1028  0.357
2004 Wada T, Penninger JM. Stress Kinase MKK7: Saviour of Cell Cycle Arrest and Cellular Senescence Cell Cycle. 3: 575-577. DOI: 10.4161/Cc.3.5.888  0.359
2004 Eriksson U, Penninger JM, Kopf M. Mechanisms of autoimmune heart disease Drug Discovery Today: Disease Mechanisms. 1: 283-288. DOI: 10.1016/J.Ddmec.2004.11.011  0.319
2003 Suzuki N, Suzuki S, Eriksson U, Hara H, Mirtosis C, Chen NJ, Wada T, Bouchard D, Hwang I, Takeda K, Fujita T, Der S, Penninger JM, Akira S, Saito T, et al. IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC. Journal of Immunology (Baltimore, Md. : 1950). 171: 6065-71. PMID 14634120 DOI: 10.4049/Jimmunol.171.11.6065  0.334
2003 Eriksson U, Ricci R, Hunziker L, Kurrer MO, Oudit GY, Watts TH, Sonderegger I, Bachmaier K, Kopf M, Penninger JM. Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nature Medicine. 9: 1484-90. PMID 14625544 DOI: 10.1038/Nm960  0.366
2003 Nishitai G, Shimizu N, Negishi T, Kishimoto H, Nakagawa K, Kitagawa D, Watanabe T, Momose H, Ohata S, Tanemura S, Asaka S, Kubota J, Saito R, Yoshida H, Mak TW, ... ... Penninger JM, et al. Stress induces mitochondria-mediated apoptosis independent of SAPK/JNK activation in embryonic stem cells. The Journal of Biological Chemistry. 279: 1621-6. PMID 14585831 DOI: 10.1074/Jbc.M310335200  0.367
2003 Griffiths EK, Sanchez O, Mill P, Krawczyk C, Hojilla CV, Rubin E, Nau MM, Khokha R, Lipkowitz S, Hui CC, Penninger JM. Cbl-3-deficient mice exhibit normal epithelial development. Molecular and Cellular Biology. 23: 7708-18. PMID 14560016 DOI: 10.1128/Mcb.23.21.7708-7718.2003  0.793
2003 Kim C, Marchal CC, Penninger J, Dinauer MC. The hemopoietic Rho/Rac guanine nucleotide exchange factor Vav1 regulates N-formyl-methionyl-leucyl-phenylalanine-activated neutrophil functions. Journal of Immunology (Baltimore, Md. : 1950). 171: 4425-30. PMID 14530369 DOI: 10.4049/Jimmunol.171.8.4425  0.373
2003 Oudit GY, Crackower MA, Eriksson U, Sarao R, Kozieradzki I, Sasaki T, Irie-Sasaki J, Gidrewicz D, Rybin VO, Wada T, Steinberg SF, Backx PH, Penninger JM. Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation. 108: 2147-52. PMID 12963636 DOI: 10.1161/01.Cir.0000091403.62293.2B  0.33
2003 Hara H, Wada T, Bakal C, Kozieradzki I, Suzuki S, Suzuki N, Nghiem M, Griffiths EK, Krawczyk C, Bauer B, D'Acquisto F, Ghosh S, Yeh WC, Baier G, Rottapel R, ... Penninger JM, et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity. 18: 763-75. PMID 12818158 DOI: 10.1016/S1074-7613(03)00148-1  0.795
2003 Jun JE, Wilson LE, Vinuesa CG, Lesage S, Blery M, Miosge LA, Cook MC, Kucharska EM, Hara H, Penninger JM, Domashenz H, Hong NA, Glynne RJ, Nelms KA, Goodnow CC. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity. 18: 751-62. PMID 12818157 DOI: 10.1016/S1074-7613(03)00141-9  0.402
2003 Gonzalez-Espinosa C, Odom S, Olivera A, Hobson JP, Martinez ME, Oliveira-Dos-Santos A, Barra L, Spiegel S, Penninger JM, Rivera J. Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells. The Journal of Experimental Medicine. 197: 1453-65. PMID 12782712 DOI: 10.1084/Jem.20021806  0.375
2003 Nakashima T, Wada T, Penninger JM. RANKL and RANK as novel therapeutic targets for arthritis. Current Opinion in Rheumatology. 15: 280-7. PMID 12707582 DOI: 10.1097/00002281-200305000-00016  0.33
2003 Oudit GY, Crackower MA, Backx PH, Penninger JM. The role of ACE2 in cardiovascular physiology. Trends in Cardiovascular Medicine. 13: 93-101. PMID 12691672 DOI: 10.1016/S1050-1738(02)00233-5  0.31
2003 Irie-Sasaki J, Sasaki T, Penninger JM. CD45 regulated signaling pathways. Current Topics in Medicinal Chemistry. 3: 783-96. PMID 12678844 DOI: 10.2174/1568026033452339  0.33
2003 Cheng HY, Penninger JM. When the DREAM is gone: from basic science to future prospectives in pain management and beyond. Expert Opinion On Therapeutic Targets. 7: 249-63. PMID 12667101 DOI: 10.1517/14728222.7.2.249  0.656
2003 Kishimoto H, Nakagawa K, Watanabe T, Kitagawa D, Momose H, Seo J, Nishitai G, Shimizu N, Ohata S, Tanemura S, Asaka S, Goto T, Fukushi H, Yoshida H, Suzuki A, ... ... Penninger JM, et al. Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. The Journal of Biological Chemistry. 278: 16595-601. PMID 12624093 DOI: 10.1074/Jbc.M213182200  0.319
2003 Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P, Penninger J, Barber B, Hunt DF, Ohashi PS. Weak agonist self-peptides promote selection and tuning of virus-specific T cells. European Journal of Immunology. 33: 685-96. PMID 12616489 DOI: 10.1002/Eji.200323143  0.329
2003 Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. The Journal of Clinical Investigation. 111: 445-52. PMID 12588882 DOI: 10.1172/Jci15598  0.366
2003 Eriksson U, Kurrer MO, Sonderegger I, Iezzi G, Tafuri A, Hunziker L, Suzuki S, Bachmaier K, Bingisser RM, Penninger JM, Kopf M. Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis. The Journal of Experimental Medicine. 197: 323-31. PMID 12566416 DOI: 10.1084/Jem.20021788  0.308
2003 Gukovsky I, Cheng JH, Nam KJ, Lee OT, Lugea A, Penninger JM, Pandol SJ, Gukovskaya AS. Phosphatidylinositide 3-kinase (PI3K) gamma regulates key pathologic responses to CCK in the pancreatic acinar cell Gastroenterology. 124: A500. DOI: 10.1016/S0016-5085(03)82532-5  0.325
2002 Cheng HY, Penninger JM. Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management? Expert Review of Neurotherapeutics. 2: 677-89. PMID 19810984 DOI: 10.1586/14737175.2.5.677  0.645
2002 Matsumoto G, Tsunematsu S, Tsukinoki K, Ohmi Y, Iwamiya M, Oliveira-dos-Santos A, Tone D, Shindo J, Penninger JM. Essential role of the adhesion receptor LFA-1 for T cell-dependent fulminant hepatitis. Journal of Immunology (Baltimore, Md. : 1950). 169: 7087-96. PMID 12471145 DOI: 10.4049/Jimmunol.169.12.7087  0.347
2002 Jones DH, Kong YY, Penninger JM. Role of RANKL and RANK in bone loss and arthritis. Annals of the Rheumatic Diseases. 61: ii32-9. PMID 12379618 DOI: 10.1136/Ard.61.Suppl_2.Ii32  0.327
2002 Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, ... ... Penninger JM, et al. SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis. Developmental Biology. 250: 332-47. PMID 12376107 DOI: 10.1006/Dbio.2002.0781  0.323
2002 Crackower MA, Oudit GY, Kozieradzki I, Sarao R, Sun H, Sasaki T, Hirsch E, Suzuki A, Shioi T, Irie-Sasaki J, Sah R, Cheng HY, Rybin VO, Lembo G, Fratta L, ... ... Penninger JM, et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell. 110: 737-49. PMID 12297047 DOI: 10.1016/S0092-8674(02)00969-8  0.693
2002 Tani-Ishii N, Penninger JM, Matsumoto G, Teranaka T, Umemoto T. The role of LFA-1 in osteoclast development induced by co-cultures of mouse bone marrow cells and MC3T3-G2/PA6 cells. Journal of Periodontal Research. 37: 184-91. PMID 12113552 DOI: 10.1034/J.1600-0765.2002.00610.X  0.375
2002 Opavsky MA, Martino T, Rabinovitch M, Penninger J, Richardson C, Petric M, Trinidad C, Butcher L, Chan J, Liu PP. Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. The Journal of Clinical Investigation. 109: 1561-9. PMID 12070303 DOI: 10.1172/Jci13971  0.416
2002 Griffiths EK, Penninger JM. Communication between the TCR and integrins: role of the molecular adapter ADAP/Fyb/Slap. Current Opinion in Immunology. 14: 317-22. PMID 11973129 DOI: 10.1016/S0952-7915(02)00334-5  0.763
2002 Griffiths EK, Penninger JM. ADAP-ting TCR signaling to integrins. Science's Stke : Signal Transduction Knowledge Environment. 2002: re3. PMID 11943877 DOI: 10.1126/Stke.2002.127.Re3  0.765
2002 Sasaki T, Suzuki A, Sasaki J, Penninger JM. Phosphoinositide 3-kinases in immunity: lessons from knockout mice. Journal of Biochemistry. 131: 495-501. PMID 11926985 DOI: 10.1093/Oxfordjournals.Jbchem.A003126  0.339
2002 Suzuki N, Suzuki S, Duncan GS, Millar DG, Wada T, Mirtsos C, Takada H, Wakeham A, Itie A, Li S, Penninger JM, Wesche H, Ohashi PS, Mak TW, Yeh WC. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature. 416: 750-6. PMID 11923871 DOI: 10.1038/Nature736  0.331
2002 Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 16: 331-43. PMID 11911819 DOI: 10.1016/S1074-7613(02)00291-1  0.792
2002 Joza N, Kroemer G, Penninger JM. Genetic analysis of the mammalian cell death machinery. Trends in Genetics : Tig. 18: 142-9. PMID 11858838 DOI: 10.1016/S0168-9525(01)02618-X  0.312
2002 Cheng HY, Pitcher GM, Laviolette SR, Whishaw IQ, Tong KI, Kockeritz LK, Wada T, Joza NA, Crackower M, Goncalves J, Sarosi I, Woodgett JR, Oliveira-dos-Santos AJ, Ikura M, van der Kooy D, ... ... Penninger JM, et al. DREAM is a critical transcriptional repressor for pain modulation. Cell. 108: 31-43. PMID 11792319 DOI: 10.1016/S0092-8674(01)00629-8  0.647
2002 Yum HK, Arcaroli J, Kupfner J, Shenkar R, Penninger JM, Sasaki T, Yang KY, Park JS, Abraham E. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. Journal of Immunology (Baltimore, Md. : 1950). 167: 6601-8. PMID 11714830 DOI: 10.4049/Jimmunol.167.11.6601  0.317
2002 Kurrer MO, Kopf M, Penninger JM, Eriksson U. Cytokines that regulate autoimmune myocarditis. Swiss Medical Weekly. 132: 408-413. DOI: 10.4414/Smw.2002.10054  0.35
2001 Mak TW, Penninger JM, Ohashi PS. Knockout mice: A paradigm shift in modern immunology Nature Reviews Immunology. 1: 11-19. PMID 11905810 DOI: 10.1038/3509551  0.37
2001 Theill LE, Boyle WJ, Penninger JM. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annual Review of Immunology. 20: 795-823. PMID 11861618 DOI: 10.1146/Annurev.Immunol.20.100301.064753  0.354
2001 Griffiths EK, Krawczyk C, Kong YY, Raab M, Hyduk SJ, Bouchard D, Chan VS, Kozieradzki I, Oliveira-Dos-Santos AJ, Wakeham A, Ohashi PS, Cybulsky MI, Rudd CE, Penninger JM. Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap. Science (New York, N.Y.). 293: 2260-3. PMID 11567140 DOI: 10.1126/Science.1063397  0.806
2001 Sasaki T, Wada T, Kishimoto H, Irie-Sasaki J, Matsumoto G, Goto T, Yao Z, Wakeham A, Mak TW, Suzuki A, Cho SK, Zuniga-Pflucker JC, Oliveira-dos-Santos AJ, Katada T, Nishina H, ... Penninger JM, et al. The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells. The Journal of Experimental Medicine. 194: 757-68. PMID 11560992 DOI: 10.1084/Jem.194.6.757  0.4
2001 Sasaki T, Sasaki-Irie J, Penninger JM. New insights into the transmembrane protein tyrosine phosphatase CD45. The International Journal of Biochemistry & Cell Biology. 33: 1041-6. PMID 11551820 DOI: 10.1016/S1357-2725(01)00075-9  0.343
2001 Sohal DS, Nghiem M, Crackower MA, Witt SA, Kimball TR, Tymitz KM, Penninger JM, Molkentin JD. Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein. Circulation Research. 89: 20-5. PMID 11440973 DOI: 10.1161/Hh1301.092687  0.341
2001 Wada T, Nakagawa K, Watanabe T, Nishitai G, Seo J, Kishimoto H, Kitagawa D, Sasaki T, Penninger JM, Nishina H, Katada T. Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation. The Journal of Biological Chemistry. 276: 30892-7. PMID 11418587 DOI: 10.1074/Jbc.M011780200  0.308
2001 Suzuki A, Yamaguchi MT, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi PS, Koyasu S, Penninger JM, Nakano T, et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity. 14: 523-34. PMID 11371355 DOI: 10.1016/S1074-7613(01)00134-0  0.42
2001 Tafuri A, Shahinian A, Bladt F, Yoshinaga SK, Jordana M, Wakeham A, Boucher LM, Bouchard D, Chan VS, Duncan G, Odermatt B, Ho A, Itie A, Horan T, Whoriskey JS, ... ... Penninger JM, et al. ICOS is essential for effective T-helper-cell responses. Nature. 409: 105-9. PMID 11343123 DOI: 10.1038/35051113  0.424
2001 Penninger JM, Irie-Sasaki J, Sasaki T, Oliveira-dos-Santos AJ. CD45: new jobs for an old acquaintance. Nature Immunology. 2: 389-96. PMID 11323691 DOI: 10.1038/87687  0.322
2001 Krawczyk C, Penninger JM. Molecular controls of antigen receptor clustering and autoimmunity. Trends in Cell Biology. 11: 212-20. PMID 11316610 DOI: 10.1016/S0962-8924(01)01981-X  0.723
2001 Bony C, Roche S, Shuichi U, Sasaki T, Crackower MA, Penninger J, Mano H, Pucéat M. A specific role of phosphatidylinositol 3-kinase gamma. A regulation of autonomic Ca(2)+ oscillations in cardiac cells. The Journal of Cell Biology. 152: 717-28. PMID 11266463 DOI: 10.1083/Jcb.152.4.717  0.366
2001 Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, ... Penninger JM, et al. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature. 409: 349-54. PMID 11201744 DOI: 10.1038/35053086  0.793
2001 Diao J, Khine AA, Sarangi F, Hsu E, Iorio C, Tibbles LA, Woodgett JR, Penninger J, Richardson CD. X Protein of Hepatitis B Virus Inhibits Fas-mediated Apoptosis and is Associated with Up-regulation of the SAPK/JNK Pathway Journal of Biological Chemistry. 276: 8328-8340. PMID 11099494 DOI: 10.1074/Jbc.M006026200  0.35
2001 Krawczyk C, Penninger JM. Molecular motors involved in T cell receptor clusterings. Journal of Leukocyte Biology. 69: 317-330. DOI: 10.1189/Jlb.69.3.317  0.676
2000 Matsumoto G, Omi Y, Lee U, Nishimura T, Shindo J, Penninger JM. Adhesion mediated by LFA-1 is required for efficient IL-12-induced NK and NKT cell cytotoxicity. European Journal of Immunology. 30: 3723-31. PMID 11169416 DOI: 10.1002/1521-4141(200012)30:12<3723::Aid-Immu3723>3.0.Co;2-9  0.327
2000 Kong YY, Boyle WJ, Penninger JM. Osteoprotegerin ligand: a regulator of immune responses and bone physiology. Immunology Today. 21: 495-502. PMID 11071528 DOI: 10.1016/S0167-5699(00)01718-7  0.336
2000 Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 13: 463-73. PMID 11070165 DOI: 10.1016/S1074-7613(00)00046-7  0.697
2000 Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103: 41-50. PMID 11051546 DOI: 10.1016/S0092-8674(00)00103-3  0.353
2000 Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE, Bai D, Houston FP, Whishaw IQ, Mariathasan S, Sasaki T, Wakeham A, Ohashi PS, Roder JC, Barnes CA, Siderovski DP, Penninger JM. Regulation of T cell activation, anxiety, and male aggression by RGS2. Proceedings of the National Academy of Sciences of the United States of America. 97: 12272-7. PMID 11027316 DOI: 10.1073/Pnas.220414397  0.417
2000 Teng YT, Nguyen H, Gao X, Kong YY, Gorczynski RM, Singh B, Ellen RP, Penninger JM. Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection. The Journal of Clinical Investigation. 106: R59-67. PMID 10995794 DOI: 10.1172/Jci10763  0.367
2000 Sasaki T, Irie-Sasaki J, Horie Y, Bachmaler K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, ... ... Penninger JM, et al. Colorectal carcinomas in mice lacking the catalytic submit of PI(3)kγ Nature. 406: 897-902. PMID 10972292 DOI: 10.1038/35022585  0.36
2000 Liu P, Aitken K, Kong YY, Opavsky MA, Martino T, Dawood F, Wen WH, Kozieradzki I, Bachmaier K, Straus D, Mak TW, Penninger JM. The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease. Nature Medicine. 6: 429-34. PMID 10742150 DOI: 10.1038/74689  0.326
2000 Sasaki T, Irie-Sasaki J, Jones RG, Oliveira-Dos-Santos AJ, Stanford WL, Bolon B, Wakeham A, Itie A, Bouchard D, Kozieradzki I, Joza N, Mak TW, Ohashi PS, Suzuki A, Penninger JM. Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration Science. 287: 1040-4046. PMID 10669416 DOI: 10.1126/Science.287.5455.1040  0.431
2000 Bachmaier K, Krawczyk C, Kozieradzki I, Kong YY, Sasaki T, Oliveira-dos-Santos A, Mariathasan S, Bouchard D, Wakeham A, Itie A, Le J, Ohashi PS, Sarosi I, Nishina H, Lipkowitz S, ... Penninger JM, et al. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403: 211-6. PMID 10646608 DOI: 10.1038/35003228  0.71
1999 Kong YY, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, ... ... Penninger JM, et al. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. 402: 304-9. PMID 10580503 DOI: 10.1038/46303  0.367
1999 Zhang J, Shehabeldin A, da Cruz LA, Butler J, Somani AK, McGavin M, Kozieradzki I, dos Santos AO, Nagy A, Grinstein S, Penninger JM, Siminovitch KA. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. The Journal of Experimental Medicine. 190: 1329-42. PMID 10544204 DOI: 10.1084/Jem.190.9.1329  0.437
1999 Opavsky MA, Penninger J, Aitken K, Wen WH, Dawood F, Mak T, Liu P. Susceptibility to myocarditis is dependent on the response of alphabeta T lymphocytes to coxsackieviral infection. Circulation Research. 85: 551-8. PMID 10488058 DOI: 10.1161/01.Res.85.6.551  0.362
1999 Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S. cbl-3: A new mammalian cbl family protein Oncogene. 18: 3365-3375. PMID 10362357 DOI: 10.1038/Sj.Onc.1202753  0.309
1999 Penninger JM, Fischer KD, Sasaki T, Kozieradzki I, Le J, Tedford K, Bachmaier K, Ohashi PS, Bachmann MF. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. European Journal of Immunology. 29: 1709-18. PMID 10359126 DOI: 10.1002/(Sici)1521-4141(199905)29:05<1709::Aid-Immu1709>3.0.Co;2-O  0.413
1999 Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, ... ... Penninger JM, et al. TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes & Development. 13: 1015-24. PMID 10215628 DOI: 10.1101/Gad.13.8.1015  0.349
1999 Liu Q, Sasaki T, Kozieradzki I, Wakeham A, Itie A, Dumont DJ, Penninger JM. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes & Development. 13: 786-91. PMID 10197978 DOI: 10.1101/Gad.13.7.786  0.372
1999 Hakem A, Sasaki T, Kozieradzki I, Penninger JM. The cyclin-dependent kinase Cdk2 regulates thymocyte apoptosis. The Journal of Experimental Medicine. 189: 957-68. PMID 10075979 DOI: 10.1084/Jem.189.6.957  0.31
1999 Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, ... ... Penninger JM, et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 397: 315-23. PMID 9950424 DOI: 10.1038/16852  0.355
1999 Penninger JM, Mak TW. Thymocyte selection in Vav and IRF-1 gene-deficient mice. Immunological Reviews. 165: 149-66. PMID 9850859 DOI: 10.1111/J.1600-065X.1998.Tb01237.X  0.404
1998 Kong YY, Fischer KD, Bachmann MF, Mariathasan S, Kozieradzki I, Nghiem MP, Bouchard D, Bernstein A, Ohashi PS, Penninger JM. Vav regulates peptide-specific apoptosis in thymocytes. The Journal of Experimental Medicine. 188: 2099-111. PMID 9841924 DOI: 10.1084/Jem.188.11.2099  0.36
1998 Stambolic V, Suzuki A, de la Pompa JL, Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM, Siderovski DP, Mak TW. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. 95: 29-39. PMID 9778245 DOI: 10.1016/S0092-8674(00)81780-8  0.385
1998 Liu Q, Oliveira-Dos-Santos AJ, Mariathasan S, Bouchard D, Jones J, Sarao R, Kozieradzki I, Ohashi PS, Penninger JM, Dumont DJ. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. The Journal of Experimental Medicine. 188: 1333-42. PMID 9763612 DOI: 10.1084/Jem.188.7.1333  0.411
1998 Oliveira-dos-Santos AJ, Penninger JM, Rieker-Geley T, Matsumoto G, Mak TM, Wick G. Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. European Journal of Immunology. 28: 2882-92. PMID 9754575 DOI: 10.1002/(Sici)1521-4141(199809)28:09<2882::Aid-Immu2882>3.0.Co;2-1  0.403
1998 Yoshida H, Kong YY, Yoshida R, Elia AJ, Hakem A, Hakem R, Penninger JM, Mak TW. Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell. 94: 739-50. PMID 9753321 DOI: 10.1016/S0092-8674(00)81733-X  0.35
1998 Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94: 339-52. PMID 9708736 DOI: 10.1016/S0092-8674(00)81477-4  0.309
1998 Fischer KD, Tedford K, Penninger JM. Vav links antigen-receptor signaling to the actin cytoskeleton. Seminars in Immunology. 10: 317-27. PMID 9695188 DOI: 10.1006/Smim.1998.0124  0.43
1998 Fischer KD, Kong YY, Nishina H, Tedford K, Marengère LE, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Current Biology : Cb. 8: 554-62. PMID 9601639 DOI: 10.1016/S0960-9822(98)70224-6  0.445
1998 Penninger JM, Kroemer G. Molecular and cellular mechanisms of T lymphocyte apoptosis. Advances in Immunology. 68: 51-144. PMID 9505088 DOI: 10.1016/S0065-2776(08)60558-1  0.38
1998 Yoshida H, Nishina H, Takimoto H, Marengère LE, Wakeham AC, Bouchard D, Kong YY, Ohteki T, Shahinian A, Bachmann M, Ohashi PS, Penninger JM, Crabtree GR, Mak TW. The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production. Immunity. 8: 115-24. PMID 9462517 DOI: 10.1016/S1074-7613(00)80464-1  0.354
1997 Waterhouse P, Bachmann MF, Penninger JM, Ohashi PS, Mak TW. Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice European Journal of Immunology. 27: 1887-1892. PMID 9295023 DOI: 10.1002/Eji.1830270811  0.402
1997 Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, Wakeham A, Shahinian A, Takimoto H, Bernstein A, Mak TW, Woodgett JR, Ohashi PS, Penninger JM. Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ERK1 kinase (SEK1)/mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. The Journal of Experimental Medicine. 186: 941-53. PMID 9294148 DOI: 10.1084/Jem.186.6.941  0.381
1997 Penninger JM, Sirard C, Mittrücker HW, Chidgey A, Kozieradzki I, Nghiem M, Hakem A, Kimura T, Timms E, Boyd R, Taniguchi T, Matsuyama T, Mak TW. The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes. Immunity. 7: 243-54. PMID 9285409 DOI: 10.1016/S1074-7613(00)80527-0  0.393
1997 Penninger JM, Pummerer C, Liu P, Neu N, Bachmaier K. Cellular and molecular mechanisms of murine autoimmune myocarditis. Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. 105: 1-13. PMID 9063494 DOI: 10.1111/J.1699-0463.1997.Tb00532.X  0.338
1997 Nishina H, Fischer KD, Radvanyi L, Shahinian A, Hakem R, Rubie EA, Bernstein A, Mak TW, Woodgett JR, Penninger JM. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature. 385: 350-3. PMID 9002521 DOI: 10.1038/385350A0  0.379
1997 Oliveira-dos-Santos A, Rieker T, Penninger J, Wick G. N3 10:45 Thymic Heterotypic cell-cell interactions in gene-targeted mutant mice Developmental & Comparative Immunology. 21: 194. DOI: 10.1016/S0145-305X(97)88696-X  0.325
1996 Yeung RSM, Penninger JM, Kündig T, Khoo W, Ohashi PS, Kroemer G, Mak TW. Human CD4 and human major histocompatibility complex class II (DQ6) transgenic mice: Supersensitivity to superantigen-induced septic shock European Journal of Immunology. 26: 1074-1082. PMID 8647170 DOI: 10.1002/Eji.1830260518  0.374
1996 Amakawa R, Hakem A, Kundig TM, Matsuyama T, Simard JJ, Timms E, Wakeham A, Mittruecker HW, Griesser H, Takimoto H, Schmits R, Shahinian A, Ohashi P, Penninger JM, Mak TW. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell. 84: 551-62. PMID 8598042 DOI: 10.1016/S0092-8674(00)81031-4  0.378
1995 Liu P, Penninger J, Aitken K, Sole M, Mak T. The role of transgenic knockout models in defining the pathogenesis of viral heart disease European Heart Journal. 16: 25-27. PMID 8682095 DOI: 10.1093/Eurheartj/16.Suppl_O.25  0.352
1995 Ferrick DA, Gemmell-Hori L, Sydora B, Mulvania T, Penninger JM, Kronenberg M, Mak TW. Tolerance and self-reactivity in V gamma 1.1C gamma 4 transgenic mice. International Reviews of Immunology. 11: 295-304. PMID 7806943 DOI: 10.3109/08830189409051176  0.36
1995 Wallace VA, Kawai K, Levelt CN, Kishihara K, Molina T, Timms E, Pircher H, Penninger J, Ohashi PS, Eichmann K. T lymphocyte development in p56lck deficient mice: allelic exclusion of the TcR beta locus is incomplete but thymocyte development is not restored by TcR beta or TcR alpha beta transgenes. European Journal of Immunology. 25: 1312-8. PMID 7774634 DOI: 10.1002/Eji.1830250527  0.35
1995 Penninger JM, Mak TW. Signal transduction, mitotic catastrophes, and death in T-cell development. Immunological Reviews. 142: 231-72. PMID 7698796 DOI: 10.1111/J.1600-065X.1994.Tb00892.X  0.356
1995 Penninger JM, Schilham MW, Timms E, Wallace VA, Mak TW. T cell repertoire and clonal deletion of Mtv superantigen-reactive T cells in mice lacking CD4 and CD8 molecules. European Journal of Immunology. 25: 2115-8. PMID 7621886 DOI: 10.1002/Eji.1830250748  0.325
1995 Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (New York, N.Y.). 270: 985-8. PMID 7481803 DOI: 10.1126/Science.270.5238.985  0.426
1994 Penninger JM, Wallace VA, Timms E, Mak TW. Maternal transfer of infectious mouse mammary tumor retroviruses does not depend on clonal deletion of superantigen-reactive V beta 14+ T cells. European Journal of Immunology. 24: 1102-8. PMID 8181521 DOI: 10.1002/Eji.1830240514  0.341
1994 Penninger J, Rieker T, Romani N, Klima J, Salvenmoser W, Dietrich H, Stössel H, Wick G. Ultrastructural analysis of thymic nurse cell epithelium. European Journal of Immunology. 24: 222-228. PMID 8020559 DOI: 10.1002/Eji.1830240135  0.333
1994 Yeung RSM, Penninger J, Mak TW. T-cell development and function in gene-knockout mice. Current Opinion in Immunology. 6: 298-307. PMID 8011213 DOI: 10.1016/0952-7915(94)90105-8  0.375
1994 Kimura T, Nakayama K, Penninger J, Kitagawa M, Harada H, Matsuyama T, Tanaka N, Kamijo R, Vilcek J, Mak T. Involvement of the IRF-1 transcription factor in antiviral responses to interferons Science. 264: 1921-1924. PMID 8009222 DOI: 10.1126/Science.8009222  0.314
1994 Yeung RS, Penninger JM, Kündig TM, Law Y, Yamamoto K, Kamikawaji N, Burkly L, Sasazuki T, Flavell R, Ohashi PS, Mak TW. Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. The Journal of Experimental Medicine. 180: 1911-20. PMID 7964466 DOI: 10.1084/Jem.180.5.1911  0.352
1994 Koh D, Ho A, Rahemtulla A, Penninger J, Mak T. Experimental allergic encephalomyelitis (EAE) in mice lacking CD4+ T cells European Journal of Immunology. 24: 2250-2253. PMID 7916298 DOI: 10.1002/Eji.1830240947  0.375
1993 Wallace VA, Penninger J, Mak TW. CD4, CD8 and tyrosine kinases in thymic selection. Current Opinion in Immunology. 5: 235-40. PMID 8507400 DOI: 10.1016/0952-7915(93)90010-P  0.334
1993 Penninger J, Kishihara K, Molina T, Wallace VA, Timms E, Hedrick SM, Mak TW. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science (New York, N.Y.). 260: 358-61. PMID 8469988 DOI: 10.1126/Science.8469988  0.372
1993 Kishihara K, Penninger J, Wallace VA, Kündig TM, Kawai K, Wakeham A, Timms E, Pfeffer K, Ohashi PS, Thomas ML. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell. 74: 143-56. PMID 8334701 DOI: 10.1016/0092-8674(93)90302-7  0.361
1993 Penninger JM, Wallace VA, Kishihara K, Mak TW. The role of p56lck and p59fyn tyrosine kinases and CD45 protein tyrosine phosphatase in T-cell development and clonal selection. Immunological Reviews. 135: 183-214. PMID 8282313 DOI: 10.1111/J.1600-065X.1993.Tb00649.X  0.346
1993 Penninger JM, Neu N, Timms E, Wallace VA, Koh DR, Kishihara K, Pummerer C, Mak TW. The induction of experimental autoimmune myocarditis in mice lacking CD4 or CD8 molecules [corrected]. The Journal of Experimental Medicine. 178: 1837-42. PMID 8228830 DOI: 10.1084/Jem.178.5.1837  0.308
1993 Rieker T, Penninger J, Hala K, Cooper MD, Wick G. In situ analyses of in ovo graft-vs.-host reaction induced by thymic nurse cell lymphocytes. European Journal of Immunology. 23: 904-10. PMID 8096184 DOI: 10.1002/Eji.1830230421  0.338
1992 Penninger J, Wick G. Thymic nurse cell lymphocytes react against self major histocompatibility complex. European Journal of Immunology. 22: 79-83. PMID 1730263 DOI: 10.1002/Eji.1830220113  0.314
1992 Wallace VA, Fung-Leung WP, Timms E, Gray D, Kishihara K, Loh DY, Penninger J, Mak TW. CD45RA and CD45RBhigh expression induced by thymic selection events. The Journal of Experimental Medicine. 176: 1657-63. PMID 1460424 DOI: 10.1084/Jem.176.6.1657  0.364
1992 Wallace VA, Rahemtulla A, Timms E, Penninger J, Mak TW. CD4 expression is differentially required for deletion of MLS-1a-reactive T cells. The Journal of Experimental Medicine. 176: 1459-63. PMID 1402689 DOI: 10.1084/Jem.176.5.1459  0.343
1991 Wick G, Rieker T, Penninger J. Thymic Nurse Cells: a Site for Positive Selection and Differentiation of T Cells Current Topics in Microbiology and Immunology. 173: 99-105. PMID 1914514 DOI: 10.1007/978-3-642-76492-9_14  0.35
Low-probability matches (unlikely to be authored by this person)
2017 Sato T, Sato C, Kadowaki A, Watanabe H, Ho L, Ishida J, Yamaguchi T, Kimura A, Fukamizu A, Penninger JM, Reversade B, Ito H, Imai Y, Kuba K. ELABELA - APJ axis protects from pressure overload heart failure and Angiotensin II-induced cardiac damage. Cardiovascular Research. PMID 28371822 DOI: 10.1093/Cvr/Cvx061  0.3
2010 Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY. Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress. Circulation Research. 107: 1275-89. PMID 20847309 DOI: 10.1161/Circresaha.110.229054  0.3
2012 Zhong J, Jin H, Song B, Kassiri Z, Zhang Z, Gao P, Zhu D, Penninger JM, Oudit GY. 1040 ANGIOTENSIN II-MEDIATED VASCULAR INFLAMMATION IS ACCELERATED IN ACE2 NULL MICE WITH ENHANCED PROFILIN-1 EXPRESSION Journal of Hypertension. 30: e303. DOI: 10.1097/01.Hjh.0000420984.25019.C2  0.3
2015 Grabner B, Schramek D, Mueller KM, Moll HP, Svinka J, Hoffmann T, Bauer E, Blaas L, Hruschka N, Zboray K, Stiedl P, Nivarthi H, Bogner E, Gruber W, Mohr T, ... ... Penninger JM, et al. Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis. Nature Communications. 6: 6285. PMID 25734337 DOI: 10.1038/Ncomms7285  0.299
2001 Miramar MD, Costantini P, Ravagnan L, Saraiva LM, Haouzi D, Brothers G, Penninger JM, Peleato ML, Kroemer G, Susin SA. NADH oxidase activity of mitochondrial apoptosis-inducing factor. The Journal of Biological Chemistry. 276: 16391-8. PMID 11278689 DOI: 10.1074/Jbc.M010498200  0.299
1989 Penninger J, Klima J, Kroemer G, Dietrich H, Hala K, Wick G. Intra-thymic nurse cell lymphocytes can induce a graft-versus-host reaction with high efficiency. Developmental and Comparative Immunology. 13: 313-27. PMID 2806699 DOI: 10.1016/0145-305X(89)90041-4  0.299
2019 Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, et al. Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs. Proceedings of the National Academy of Sciences of the United States of America. PMID 31189595 DOI: 10.1073/Pnas.1900152116  0.299
2019 Ang CE, Ma Q, Wapinski OL, Fan S, Flynn RA, Lee QY, Coe B, Onoguchi M, Olmos VH, Do BT, Dukes-Rimsky L, Xu J, Tanabe K, Wang L, Elling U, ... Penninger JM, et al. The novel lncRNA is pro-neurogenic and mutated in human neurodevelopmental disorders. Elife. 8. PMID 30628890 DOI: 10.7554/Elife.41770  0.299
2010 Blaas L, Kornfeld JW, Schramek D, Musteanu M, Zollner G, Gumhold J, van Zijl F, Schneller D, Esterbauer H, Egger G, Mair M, Kenner L, Mikulits W, Eferl R, Moriggl R, ... Penninger J, et al. Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology (Baltimore, Md.). 51: 1319-26. PMID 20162728 DOI: 10.1002/Hep.23469  0.299
2019 Gaweco A, Thell K, Urban M, Harrauer J, Haslinger I, Dohnal A, Lametschwandtner G, Drobits K, Gugenberger R, Muehleisen H, Penninger J, Becerra C, Chung V, El-Khoueiry A. Abstract C048: Novel master checkpoint Cbl-b siRNA-based adoptive cellular therapy: Superior antitumor efficacy in a syngeneic murine hepatocellular carcinoma Hepa1-6 model following APN401 monotherapy and synergistic effects with anti-PD1 Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-C048  0.298
2012 Qi Y, Tian X, Liu J, Han Y, Graham AM, Simon MC, Penninger JM, Carmeliet P, Li S. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. The Journal of Cell Biology. 198: 103-14. PMID 22753893 DOI: 10.1083/Jcb.201111063  0.298
2002 Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, Oliveira-dos-Santos AJ, da Costa J, Zhang L, Pei Y, Scholey J, Ferrario CM, Manoukian AS, Chappell MC, Backx PH, ... ... Penninger JM, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature. 417: 822-8. PMID 12075344 DOI: 10.1038/Nature00786  0.298
2012 Musteanu M, Blaas L, Zenz R, Svinka J, Hoffmann T, Grabner B, Schramek D, Kantner HP, Müller M, Kolbe T, Rülicke T, Moriggl R, Kenner L, Stoiber D, Penninger JM, et al. A mouse model to identify cooperating signaling pathways in cancer Nature Methods. 9: 897-900. PMID 22863881 DOI: 10.1038/Nmeth.2130  0.297
2013 Ichikawa A, Kuba K, Morita M, Chida S, Tezuka H, Hara H, Sasaki T, Ohteki T, Ranieri VM, dos Santos CC, Kawaoka Y, Akira S, Luster AD, Lu B, Penninger JM, et al. CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. American Journal of Respiratory and Critical Care Medicine. 187: 65-77. PMID 23144331 DOI: 10.1164/Rccm.201203-0508Oc  0.297
2016 Nunes-Souza V, Alenina N, Qadri F, Penninger JM, Santos RA, Bader M, Rabelo LA. CD36/Sirtuin 1 Axis Impairment Contributes to Hepatic Steatosis in ACE2-Deficient Mice. Oxidative Medicine and Cellular Longevity. 2016: 6487509. PMID 28101297 DOI: 10.1155/2016/6487509  0.297
2013 Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H. Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity. The Journal of Biological Chemistry. 288: 5562-71. PMID 23319583 DOI: 10.1074/Jbc.M112.426080  0.297
2003 Danilczyk U, Eriksson U, Crackower MA, Penninger JM. A story of two ACEs. Journal of Molecular Medicine (Berlin, Germany). 81: 227-34. PMID 12700890 DOI: 10.1007/S00109-003-0419-X  0.296
2014 Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP. HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress. Nature Communications. 5: 3430. PMID 24614889 DOI: 10.1038/Ncomms4430  0.295
1997 Yao Z, Diener K, Wang XS, Zukowski M, Matsumoto G, Zhou G, Mo R, Sasaki T, Nishina H, Hui CC, Tan TH, Woodgett JP, Penninger JM. Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase. The Journal of Biological Chemistry. 272: 32378-83. PMID 9405446 DOI: 10.1074/Jbc.272.51.32378  0.295
2018 Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Penninger JM, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4  0.295
2006 Vorbach C, Capecchi MR, Penninger JM. Evolution of the mammary gland from the innate immune system? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 28: 606-16. PMID 16700061 DOI: 10.1002/Bies.20423  0.295
2001 Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, ... ... Penninger JM, et al. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature. 410: 549-54. PMID 11279485 DOI: 10.1038/35069004  0.295
2013 Daugaard M, Nitsch R, Razaghi B, McDonald L, Jarrar A, Torrino S, Castillo-Lluva S, Rotblat B, Li L, Malliri A, Lemichez E, Mettouchi A, Berman JN, Penninger JM, Sorensen PH. Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nature Communications. 4: 2180. PMID 23864022 DOI: 10.1038/Ncomms3180  0.295
2009 Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, Butany J. SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS European Journal of Clinical Investigation. 39: 618-625. PMID 19453650 DOI: 10.1111/J.1365-2362.2009.02153.X  0.294
2007 Nishio M, Watanabe K, Sasaki J, Taya C, Takasuga S, Iizuka R, Balla T, Yamazaki M, Watanabe H, Itoh R, Kuroda S, Horie Y, Förster I, Mak TW, Yonekawa H, ... Penninger JM, et al. Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nature Cell Biology. 9: 36-44. PMID 17173042 DOI: 10.1038/Ncb1515  0.294
2013 Kuba K, Imai Y, Penninger JM. Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases. Circulation Journal : Official Journal of the Japanese Circulation Society. 77: 301-8. PMID 23328447 DOI: 10.1253/Circj.Cj-12-1544  0.294
2010 Saade M, Irla M, Yammine M, Boulanger N, Victorero G, Vincentelli R, Penninger JM, Holländer GA, Chauvet S, Nguyen C. Spatial (Tbata) expression in mature medullary thymic epithelial cells. European Journal of Immunology. 40: 530-8. PMID 19918778 DOI: 10.1002/Eji.200939605  0.294
1996 Pummerer CL, Luze K, Grässl G, Bachmaier K, Offner F, Burrell SK, Lenz DM, Zamborelli TJ, Penninger JM, Neu N. Identification of cardiac myosin peptides capable of inducing autoimmune myocarditis in BALB/c mice. The Journal of Clinical Investigation. 97: 2057-62. PMID 8621795 DOI: 10.1172/Jci118642  0.294
2011 Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, Penninger JM, Scholey JW, Kassiri Z, Oudit GY. Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 57: 314-22. PMID 21189404 DOI: 10.1161/Hypertensionaha.110.164244  0.294
2012 Zhong J, Song B, Jin H, Wang J, Oudit GY, Ning G, Zhang Z, Davidge ST, Penninger JM. 1039 ACE2 DEFICIENCY FACILIATES ANGIOTENSIN II-MEDIATED VASCULAR PEROXYNITRITE PRODUCTION WITH ACTIVATION OF THE AKT/ENOS SIGNALING Journal of Hypertension. 30: e302-e303. DOI: 10.1097/01.Hjh.0000420983.17396.35  0.294
2017 Nakamura M, Nakamichi Y, Mizoguchi T, Koide M, Yamashita T, Ara T, Nakamura H, Penninger JM, Furuya Y, Yasuda H, Udagawa N. The W9 peptide directly stimulates osteoblast differentiation via RANKL signaling Journal of Oral Biosciences. 59: 146-151. DOI: 10.1016/J.Job.2017.05.001  0.293
2013 Raith M, Valencia RG, Fischer I, Orthofer M, Penninger JM, Spuler S, Rezniczek GA, Wiche G. Linking cytoarchitecture to metabolism: sarcolemma-associated plectin affects glucose uptake by destabilizing microtubule networks in mdx myofibers. Skeletal Muscle. 3: 14. PMID 23758845 DOI: 10.1186/2044-5040-3-14  0.293
2015 Nagy V, Penninger JM. The RANKL-RANK Story. Gerontology. PMID 25720990 DOI: 10.1159/000371845  0.293
2019 Openshaw RL, Kwon J, McColl A, Penninger JM, Cavanagh J, Pratt JA, Morris BJ. JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. Journal of Neuroinflammation. 16: 18. PMID 30691477 DOI: 10.1186/S12974-019-1408-5  0.293
2008 Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, ... ... Penninger JM, et al. Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 133: 235-49. PMID 18423196 DOI: 10.1016/J.Cell.2008.02.043  0.293
2000 Kong YY, Penninger JM. Molecular control of bone remodeling and osteoporosis. Experimental Gerontology. 35: 947-56. PMID 11121682 DOI: 10.1016/S0531-5565(00)00178-9  0.292
1991 Fedecka-Bruner B, Penninger J, Vaigot P, Lehmann A, Martínez C, Kroemer G. Developmental expression of IL-2-receptor light chain (CD25) in the chicken embryo. Developmental Immunology. 1: 237-42. PMID 1840381 DOI: 10.1155/1991/95302  0.292
2018 Landmann J, Richter F, Classen J, Richter A, Penninger JM, Bechmann I. Behavioral phenotyping of calcium channel (CACN) subunit α2δ3 knockout mice: Consequences of sensory cross-modal activation. Behavioural Brain Research. PMID 29305318 DOI: 10.1016/J.Bbr.2017.12.032  0.292
2005 Liu YC, Penninger J, Karin M. Immunity by ubiquitylation: a reversible process of modification. Nature Reviews. Immunology. 5: 941-52. PMID 16322747 DOI: 10.1038/Nri1731  0.292
2003 Sasaki T, Irie-Sasaki J, Horie Y, Bachmaier K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, ... ... Penninger JM, et al. Erratum: Corrigendum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ Nature. 426: 584-584. DOI: 10.1038/Nature02203  0.292
2015 Nakajima K, Zhu K, Sun YH, Hegyi B, Zeng Q, Murphy CJ, Small JV, Chen-Izu Y, Izumiya Y, Penninger JM, Zhao M. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nature Communications. 6: 8532. PMID 26449415 DOI: 10.1038/Ncomms9532  0.292
2006 Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, ... ... Penninger JM, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442: 457-60. PMID 16871217 DOI: 10.1038/Nature04925  0.291
2011 Taschler U, Radner FP, Heier C, Schreiber R, Schweiger M, Schoiswohl G, Preiss-Landl K, Jaeger D, Reiter B, Koefeler HC, Wojciechowski J, Theussl C, Penninger JM, Lass A, Haemmerle G, et al. Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance. The Journal of Biological Chemistry. 286: 17467-77. PMID 21454566 DOI: 10.1074/Jbc.M110.215434  0.291
2003 Suzuki N, Chen NJ, Millar DG, Suzuki S, Horacek T, Hara H, Bouchard D, Nakanishi K, Penninger JM, Ohashi PS, Yeh WC. IL-1 receptor-associated kinase 4 is essential for IL-18-mediated NK and Th1 cell responses. Journal of Immunology (Baltimore, Md. : 1950). 170: 4031-5. PMID 12682231 DOI: 10.4049/Jimmunol.170.8.4031  0.291
1990 Penninger J, Hála K, Wick G. Intrathymic nurse cell lymphocytes can induce a specific graft-versus-host reaction. Journal of Experimental Medicine. 172: 521-529. PMID 2142720 DOI: 10.1084/Jem.172.2.521  0.291
1993 Yeung RSM, Penninger J, Mak TW. Genetically modified animals and immunodeficiency Current Opinion in Immunology. 5: 585-594. PMID 8105804 DOI: 10.1016/0952-7915(93)90042-Q  0.291
2009 Oudit GY, Imai Y, Kuba K, Scholey JW, Penninger JM. The role of ACE2 in pulmonary diseases--relevance for the nephrologist. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 24: 1362-5. PMID 19228756 DOI: 10.1093/Ndt/Gfp065  0.291
1999 Bachmaier K, Neu N, de la Maza LM, Pal S, Hessel A, Penninger JM. Chlamydia infections and heart disease linked through antigenic mimicry. Science (New York, N.Y.). 283: 1335-9. PMID 10037605 DOI: 10.1126/Science.283.5406.1335  0.291
2011 Schramek D, Kotsinas A, Meixner A, Wada T, Elling U, Pospisilik JA, Neely GG, Zwick RH, Sigl V, Forni G, Serrano M, Gorgoulis VG, Penninger JM. The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression Nature Genetics. 43: 212-219. PMID 21317887 DOI: 10.1038/Ng.767  0.291
2009 Loeser S, Penninger JM. Regulation of T Cell Anergy and Escape from Regulatory T Cell Suppression by Cbl-b The Epigenetics of Autoimmune Diseases. 75-94. DOI: 10.1002/9780470743553.ch5  0.291
2011 Elling U, Taubenschmid J, Wirnsberger G, O'Malley R, Demers SP, Vanhaelen Q, Shukalyuk AI, Schmauss G, Schramek D, Schnuetgen F, Von Melchner H, Ecker JR, Stanford WL, Zuber J, Stark A, ... Penninger JM, et al. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells Cell Stem Cell. 9: 563-574. PMID 22136931 DOI: 10.1016/J.Stem.2011.10.012  0.291
2002 Maté MJ, Ortiz-Lombardía M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM. The crystal structure of the mouse apoptosis-inducing factor AIF. Nature Structural Biology. 9: 442-6. PMID 11967568 DOI: 10.1038/Nsb793  0.291
1999 Bachmaier K, Neu N, Yeung RS, Mak TW, Liu P, Penninger JM. Generation of humanized mice susceptible to peptide-induced inflammatory heart disease. Circulation. 99: 1885-91. PMID 10199887 DOI: 10.1161/01.Cir.99.14.1885  0.29
2017 Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE. Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species. Oncogene. PMID 28581519 DOI: 10.1038/Onc.2017.175  0.29
2015 Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, Diemen FRv, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S. Author response: Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome Elife. DOI: 10.7554/Elife.08467.021  0.29
2015 Nagy V, Cole T, Van Campenhout C, Khoung TM, Leung C, Vermeiren S, Novatchkova M, Wenzel D, Cikes D, Polyansky AA, Kozieradzki I, Meixner A, Bellefroid EJ, Neely GG, Penninger JM. The evolutionarily conserved transcription factor PRDM12 controls sensory neuron development and pain perception. Cell Cycle (Georgetown, Tex.). 14: 1799-808. PMID 25891934 DOI: 10.1080/15384101.2015.1036209  0.29
2017 Stadlmann J, Taubenschmid J, Wenzel D, Gattinger A, Dürnberger G, Dusberger F, Elling U, Mach L, Mechtler K, Penninger JM. Comparative glycoproteomics of stem cells identifies new players in ricin toxicity. Nature. 549: 538-542. PMID 28959962 DOI: 10.1038/Nature24015  0.29
2017 Elling U, Wimmer RA, Leibbrandt A, Burkard T, Michlits G, Leopoldi A, Micheler T, Abdeen D, Zhuk S, Aspalter IM, Handl C, Liebergesell J, Hubmann M, Husa AM, Kinzer M, ... ... Penninger JM, et al. A reversible haploid mouse embryonic stem cell biobank resource for functional genomics. Nature. PMID 28953874 DOI: 10.1038/Nature24027  0.289
2017 Landmann J, Richter F, Oros-Peusquens AM, Shah NJ, Classen J, Neely GG, Richter A, Penninger JM, Bechmann I. Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice. Brain Structure & Function. PMID 28733833 DOI: 10.1007/S00429-017-1473-4  0.289
2011 Jin R, Song Z, Yu S, Piazza A, Nanda A, Penninger JM, Granger DN, Li G. Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke Stroke. 42: 2033-2044. PMID 21546487 DOI: 10.1161/Strokeaha.110.601369  0.288
2018 Klempin F, Mosienko V, Matthes S, Villela DC, Todiras M, Penninger JM, Bader M, Santos RAS, Alenina N. Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response. Cellular and Molecular Life Sciences : Cmls. PMID 29679094 DOI: 10.1007/S00018-018-2815-Y  0.288
2012 van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U, Allayee H, Li X, Radhakrishnan A, Tan ST, Voss K, Weichenberger CX, Albers CA, ... ... Penninger JM, et al. Seventy-five genetic loci influencing the human red blood cell. Nature. 492: 369-75. PMID 23222517 DOI: 10.1038/Nature11677  0.288
2008 Imai Y, Kuba K, Penninger JM. The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice. Experimental Physiology. 93: 543-8. PMID 18448662 DOI: 10.1113/Expphysiol.2007.040048  0.288
2018 Szappanos D, Tschismarov R, Perlot T, Westermayer S, Fischer K, Platanitis E, Kallinger F, Novatchkova M, Lassnig C, Müller M, Sexl V, Bennett KL, Foong-Sobis M, Penninger JM, Decker T. The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. Plos Pathogens. 14: e1007397. PMID 30475900 DOI: 10.1371/Journal.Ppat.1007397  0.288
2002 Ito N, Yokomizo T, Sasaki T, Kurosu H, Penninger J, Kanaho Y, Katada T, Hanaoka K, Shimizu T. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. The Journal of Biological Chemistry. 277: 44898-904. PMID 12244116 DOI: 10.1074/Jbc.M208051200  0.288
2006 Cheung EC, Joza N, Steenaart NA, McClellan KA, Neuspiel M, McNamara S, MacLaurin JG, Rippstein P, Park DS, Shore GC, McBride HM, Penninger JM, Slack RS. Dissociating the dual roles of apoptosis-inducing factor in maintaining mitochondrial structure and apoptosis. The Embo Journal. 25: 4061-73. PMID 16917506 DOI: 10.1038/Sj.Emboj.7601276  0.288
2014 Sigl V, Penninger JM. RANKL/RANK - from bone physiology to breast cancer. Cytokine & Growth Factor Reviews. 25: 205-14. PMID 24486161 DOI: 10.1016/J.Cytogfr.2014.01.002  0.287
2014 Karaca E, Weitzer S, Pehlivan D, Shiraishi H, Gogakos T, Hanada T, Jhangiani SN, Wiszniewski W, Withers M, Campbell IM, Erdin S, Isikay S, Franco LM, Gonzaga-Jauregui C, Gambin T, ... ... Penninger JM, et al. Human CLP1 mutations alter tRNA biogenesis, affecting both peripheral and central nervous system function. Cell. 157: 636-50. PMID 24766809 DOI: 10.1016/J.Cell.2014.02.058  0.287
2000 Penninger JM, Bachmaier K. Review of microbial infections and the immune response to cardiac antigens. The Journal of Infectious Diseases. S498-504. PMID 10839747 DOI: 10.1086/315613  0.286
2016 Iwamoto Y, Nishikawa K, Imai R, Furuya M, Uenaka M, Ohta Y, Morihana T, Itoi-Ochi S, Penninger JM, Katayama I, Inohara H, Ishii M. Intercellular communication between keratinocytes and fibroblasts induces local osteoclast differentiation: a mechanism underlying cholesteatoma-induced bone destruction. Molecular and Cellular Biology. PMID 27001307 DOI: 10.1128/Mcb.01028-15  0.286
2012 Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, ... ... Penninger JM, et al. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature. 487: 477-81. PMID 22837003 DOI: 10.1038/Nature11228  0.286
2014 Elling U, Penninger JM. Genome wide functional genetics in haploid cells. Febs Letters. 588: 2415-21. PMID 24950427 DOI: 10.1016/J.Febslet.2014.06.032  0.286
2003 Eriksson U, Danilczyk U, Penninger JM. Just the beginning: novel functions for angiotensin-converting enzymes. Current Biology : Cb. 12: R745-52. PMID 12419208 DOI: 10.1016/S0960-9822(02)01255-1  0.286
2017 Tejada MA, Montilla-García A, Cronin SJ, Cikes D, Sánchez-Fernández C, González-Cano R, Ruiz-Cantero MC, Penninger JM, Vela JM, Baeyens JM, Cobos EJ. Sigma-1 receptors control immune-driven peripheral opioid analgesia during inflammation in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716934 DOI: 10.1073/Pnas.1620068114  0.285
2010 Imai Y, Kuba K, Ohto-Nakanishi T, Penninger JM. Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circulation Journal : Official Journal of the Japanese Circulation Society. 74: 405-10. PMID 20134095 DOI: 10.1253/Circj.Cj-10-0045  0.285
2010 Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, ... Penninger JM, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468: 98-102. PMID 20881962 DOI: 10.1038/Nature09387  0.285
2014 Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, ... ... Penninger JM, et al. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response. Proceedings of the National Academy of Sciences of the United States of America. 111: 3032-7. PMID 24516159 DOI: 10.1073/Pnas.1314421111  0.285
2011 Schramek D, Sigl V, Penninger JM. RANKL and RANK in sex hormone-induced breast cancer and breast cancer metastasis Trends in Endocrinology and Metabolism. 22: 188-194. PMID 21470874 DOI: 10.1016/J.Tem.2011.02.007  0.284
2015 Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY. ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity. Diabetes. PMID 26224885 DOI: 10.2337/Db15-0399  0.284
2017 Rao S, Cronin SJF, Sigl V, Penninger JM. RANKL and RANK: From Mammalian Physiology to Cancer Treatment. Trends in Cell Biology. PMID 29241686 DOI: 10.1016/J.Tcb.2017.11.001  0.284
2014 Popper HH, Grabner B, Casanova E, Eferl R, Shuan R, Penninger J. Abstract 1209: Comparison of lung adenocarcinoma development in genetically engineered mouse and in humans - similarities and differences Cancer Research. 74: 1209-1209. DOI: 10.1158/1538-7445.Am2014-1209  0.284
2013 Kiechl S, Wittmann J, Giaccari A, Knoflach M, Willeit P, Bozec A, Moschen AR, Muscogiuri G, Sorice GP, Kireva T, Summerer M, Wirtz S, Luther J, Mielenz D, Billmeier U, ... ... Penninger JM, et al. Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nature Medicine. 19: 358-63. PMID 23396210 DOI: 10.1038/Nm.3084  0.284
2018 Adamowicz M, Morgan CC, Haubner BJ, Noseda M, Collins MJ, Abreu Paiva M, Srivastava PK, Gellert P, Razzaghi B, O'Gara P, Raina P, Game L, Bottolo L, Schneider MD, Harding SE, ... Penninger J, et al. Functionally Conserved Noncoding Regulators of Cardiomyocyte Proliferation and Regeneration in Mouse and Human. Circulation. Genomic and Precision Medicine. 11: e001805. PMID 32966096 DOI: 10.1161/Circgen.117.001805  0.284
2007 Wong DW, Oudit GY, Reich H, Kassiri Z, Zhou J, Liu QC, Backx PH, Penninger JM, Herzenberg AM, Scholey JW. Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury. The American Journal of Pathology. 171: 438-51. PMID 17600118 DOI: 10.2353/Ajpath.2007.060977  0.284
2018 Lee NJ, Clarke IM, Enriquez RF, Nagy V, Penninger J, Baldock PA, Herzog H. Central RANK signalling in NPY neurons alters bone mass in male mice. Neuropeptides. PMID 29477253 DOI: 10.1016/J.Npep.2018.02.004  0.283
2010 Heindl-Erdmann C, Axmann R, Kreitz S, Zwerina J, Penninger J, Schett G, Brune K, Hess A. Combining functional magnetic resonance imaging with mouse genomics: new options in pain research Neuroreport. 21: 29-33. PMID 19934782 DOI: 10.1097/Wnr.0B013E3283324Faf  0.283
2005 Joza N, Oudit GY, Brown D, Bénit P, Kassiri Z, Vahsen N, Benoit L, Patel MM, Nowikovsky K, Vassault A, Backx PH, Wada T, Kroemer G, Rustin P, Penninger JM. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Molecular and Cellular Biology. 25: 10261-72. PMID 16287843 DOI: 10.1128/Mcb.25.23.10261-10272.2005  0.283
2013 Lo J, Patel VB, Wang Z, Levasseur J, Kaufman S, Penninger JM, Oudit GY. Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Experimental Physiology. 98: 109-22. PMID 22750422 DOI: 10.1113/Expphysiol.2012.067165  0.282
2000 Susin SA, Daugas E, Ravagnan L, Samejima K, Zamzami N, Loeffler M, Costantini P, Ferri KF, Irinopoulou T, Prévost MC, Brothers G, Mak TW, Penninger J, Earnshaw WC, Kroemer G. Two distinct pathways leading to nuclear apoptosis. The Journal of Experimental Medicine. 192: 571-80. PMID 10952727 DOI: 10.1084/Jem.192.4.571  0.282
2008 Oudit GY, Kassiri Z, Zhou J, Liu QC, Liu PP, Backx PH, Dawood F, Crackower MA, Scholey JW, Penninger JM. Loss of PTEN attenuates the development of pathological hypertrophy and heart failure in response to biomechanical stress. Cardiovascular Research. 78: 505-14. PMID 18281373 DOI: 10.1093/Cvr/Cvn041  0.281
2020 Kogler M, Tortola L, Negri GL, Leopoldi A, El-Naggar AM, Mereiter S, Gomez Diaz C, Nitsch R, Tortora D, Kavirayani AM, Gapp BV, Rao S, Uribesalgo I, Hoffmann D, Cikes D, ... ... Penninger JM, et al. HACE1 prevents lung carcinogenesis via inhibition of RAC-family GTPases. Cancer Research. PMID 32366477 DOI: 10.1158/0008-5472.Can-19-2270  0.281
2012 Xiol J, Cora E, Koglgruber R, Chuma S, Subramanian S, Hosokawa M, Reuter M, Yang Z, Berninger P, Palencia A, Benes V, Penninger J, Sachidanandam R, Pillai RS. A role for Fkbp6 and the chaperone machinery in piRNA amplification and transposon silencing. Molecular Cell. 47: 970-9. PMID 22902560 DOI: 10.1016/J.Molcel.2012.07.019  0.281
2016 Sigl V, Jones LP, Penninger JM. RANKL/RANK: from bone loss to the prevention of breast cancer. Open Biology. 6. PMID 27881737 DOI: 10.1098/Rsob.160230  0.281
2007 Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong Y, Schreiber M, Dixon SJ, Sims SM, ... ... Penninger JM, et al. Can osteoclasts be excluded? (Reply) Nature. 445: E19-E20. DOI: 10.1038/Nature05658  0.281
2017 Zhong J, Zhang Z, Jin H, Wang W, Cheng Y, Chen X, Xu Y, Song B, Penninger JM, Oudit GY. GW28-e0806 Pyr1-Apelin 13 is a negative modulator of angiotensin II-mediated adverse myocardial hypertrophy, remodeling and fibrosis Journal of the American College of Cardiology. 70: C29-C30. DOI: 10.1016/J.Jacc.2017.07.102  0.28
2010 Kuba K, Imai Y, Ohto-Nakanishi T, Penninger JM. Trilogy of ACE2: a peptidase in the renin-angiotensin system, a SARS receptor, and a partner for amino acid transporters. Pharmacology & Therapeutics. 128: 119-28. PMID 20599443 DOI: 10.1016/J.Pharmthera.2010.06.003  0.28
2007 Imai Y, Kuba K, Penninger JM. Angiotensin-converting enzyme 2 in acute respiratory distress syndrome. Cellular and Molecular Life Sciences : Cmls. 64: 2006-12. PMID 17558469 DOI: 10.1007/S00018-007-6228-6  0.28
2004 Fischer L, Gukovskaya AS, Young SH, Gukovsky I, Lugea A, Buechler P, Penninger JM, Friess H, Pandol SJ. Phosphatidylinositol 3-kinase regulates Ca2+ signaling in pancreatic acinar cells through inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G1200-12. PMID 15271649 DOI: 10.1152/Ajpgi.00212.2004  0.28
2018 Moll HP, Pranz K, Musteanu M, Grabner B, Hruschka N, Mohrherr J, Aigner P, Stiedl P, Brcic L, Laszlo V, Schramek D, Moriggl R, Eferl R, Moldvay J, Dezso K, ... ... Penninger J, et al. Afatinib restrains K-RAS-driven lung tumorigenesis. Science Translational Medicine. 10. PMID 29925635 DOI: 10.1126/Scitranslmed.Aao2301  0.28
2018 Horn M, Kroef V, Allmeroth K, Schuller N, Miethe S, Peifer M, Penninger JM, Elling U, Denzel MS. Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells. Oncotarget. 9: 9838-9851. PMID 29515774 DOI: 10.18632/Oncotarget.24305  0.279
2008 Hara H, Ishihara C, Takeuchi A, Xue L, Morris SW, Penninger JM, Yoshida H, Saito T. Cell type-specific regulation of ITAM-mediated NF-kappaB activation by the adaptors, CARMA1 and CARD9. Journal of Immunology (Baltimore, Md. : 1950). 181: 918-30. PMID 18606643 DOI: 10.4049/jimmunol.181.2.918  0.279
2005 Eriksson U, Penninger JM. Autoimmune heart failure: new understandings of pathogenesis. The International Journal of Biochemistry & Cell Biology. 37: 27-32. PMID 15381145 DOI: 10.1016/J.Biocel.2004.06.014  0.279
1995 Rieker T, Penninger J, Romani N, Georg W. Chicken thymic nurse cells: An overview Developmental and Comparative Immunology. 19: 281-289. PMID 8617399 DOI: 10.1016/0145-305X(95)00008-H  0.279
2012 Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, ... ... Penninger JM, et al. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell. 151: 414-26. PMID 23063129 DOI: 10.1016/J.Cell.2012.09.021  0.279
2018 Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca JE, Golenkina S, Cuiping X, Gruber S, Angjeli B, Kanitz EE, Cronin SJF, Neely GG, Wernitznig A, Humbert PO, Simpson KJ, ... ... Penninger JM, et al. A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer. Plos Genetics. 14: e1007688. PMID 30325918 DOI: 10.1371/Journal.Pgen.1007688  0.279
2019 Wolle P, Hardick J, Cronin SJF, Engel J, Baumann M, Lategahn J, Penninger JM, Rauh D. Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors. Journal of Medicinal Chemistry. PMID 30768270 DOI: 10.2210/Pdb6Ib2/Pdb  0.279
2004 Perfettini JL, Roumier T, Castedo M, Larochette N, Boya P, Raynal B, Lazar V, Ciccosanti F, Nardacci R, Penninger J, Piacentini M, Kroemer G. NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope. The Journal of Experimental Medicine. 199: 629-40. PMID 14993250 DOI: 10.1084/Jem.20031216  0.279
2020 Fujinami H, Shiraishi H, Hada K, Inoue M, Morisaki I, Higa R, Shin T, Kobayashi T, Hanada R, Penninger JM, Mimata H, Hanada T. CLP1 acts as the main RNA kinase in mice. Biochemical and Biophysical Research Communications. PMID 32081435 DOI: 10.1016/J.Bbrc.2020.02.066  0.278
2010 Saade M, Irla M, Yammine M, Boulanger N, Victorero G, Vincentelli R, Penninger JM, Holländer GA, Chauvet S, Nguyen C. Cover Picture: Eur. J. Immunol. 2/10 European Journal of Immunology. 40: NA-NA. DOI: 10.1002/Eji.201090005  0.278
2013 Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. Journal of the American Heart Association. 2: e000249. PMID 23817469 DOI: 10.1161/Jaha.113.000249  0.278
2004 Wang X, Huang G, Luo X, Penninger JM, Muallem S. Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells. The Journal of Biological Chemistry. 279: 41642-9. PMID 15292238 DOI: 10.1074/Jbc.M406450200  0.277
2001 Ravagnan L, Gurbuxani S, Susin SA, Maisse C, Daugas E, Zamzami N, Mak T, Jäättelä M, Penninger JM, Garrido C, Kroemer G. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nature Cell Biology. 3: 839-43. PMID 11533664 DOI: 10.1038/Ncb0901-839  0.277
2006 Sun H, Kerfant BG, Zhao D, Trivieri MG, Oudit GY, Penninger JM, Backx PH. Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling. Circulation Research. 98: 1390-7. PMID 16627784 DOI: 10.1161/01.Res.0000223321.34482.8C  0.276
2007 Zhang L, Anglesio MS, O'Sullivan M, Zhang F, Yang G, Sarao R, Mai PN, Cronin S, Hara H, Melnyk N, Li L, Wada T, Liu PP, Farrar J, Arceci RJ, ... ... Penninger JM, et al. The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers. Nature Medicine. 13: 1060-9. PMID 17694067 DOI: 10.1038/Nm1621  0.276
2011 Oudit GY, Penninger JM. Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy Current Heart Failure Reports. 8: 176-183. PMID 21611889 DOI: 10.1007/S11897-011-0063-7  0.276
2009 ZHONG J, OUDIT G, ZHU D, KASSIRI Z, GAO P, PENNINGER J. Prevention of angiotensin II-induced hypertension and cardiac remodeling by recombinant human angiotensin-converting enzyme 2 in mice International Journal of Cardiology. 137: S131. DOI: 10.1016/J.Ijcard.2009.09.446  0.276
2019 Wimmer RA, Leopoldi A, Aichinger M, Kerjaschki D, Penninger JM. Generation of blood vessel organoids from human pluripotent stem cells. Nature Protocols. PMID 31554955 DOI: 10.1038/S41596-019-0213-Z  0.276
2009 Leibbrandt A, Penninger JM. ESCI award lecture: From a little mouse to rationale medicine for bone loss European Journal of Clinical Investigation. 39: 842-850. PMID 19772521 DOI: 10.1111/J.1365-2362.2009.02215.X  0.275
2004 Anglesio MS, Evdokimova V, Melnyk N, Zhang L, Fernandez CV, Grundy PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, Sorensen PH. Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney. Human Molecular Genetics. 13: 2061-74. PMID 15254018 DOI: 10.1093/Hmg/Ddh215  0.274
2001 Loeffler M, Daugas E, Susin SA, Zamzami N, Metivier D, Nieminen AL, Brothers G, Penninger JM, Kroemer G. Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factor. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 758-67. PMID 11259394 DOI: 10.1096/Fj.00-0388Com  0.274
2018 Dufresne SS, Boulanger-Piette A, Bossé S, Argaw A, Hamoudi D, Marcadet L, Gamu D, Fajardo VA, Yagita H, Penninger JM, Russell Tupling A, Frenette J. Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy. Acta Neuropathologica Communications. 6: 31. PMID 29699580 DOI: 10.1186/S40478-018-0533-1  0.274
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Penninger JM, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.274
2015 Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, et al. CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts. The Journal of Experimental Medicine. PMID 26195726 DOI: 10.1084/Jem.20150407  0.274
2012 Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, ... ... Penninger JM, et al. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. Plos Genetics. 8: e1003071. PMID 23236288 DOI: 10.1371/Journal.Pgen.1003071  0.274
2023 Yamada D, Kojima Y, Hosoya A, Suzuki M, Watabe T, Inoue T, Tsugawa N, Asakawa T, Yonemoto Y, Onizawa M, Nemoto Y, Oshima S, Shimonaka M, Kuba K, Ishida J, ... ... Penninger JM, et al. Apelin expression is downregulated in T cells in a murine model of chronic colitis. Biochemical and Biophysical Research Communications. 647: 72-79. PMID 36731336 DOI: 10.1016/j.bbrc.2023.01.068  0.274
2012 Rey-Parra GJ, Vadivel A, Coltan L, Hall A, Eaton F, Schuster M, Loibner H, Penninger JM, Kassiri Z, Oudit GY, Thébaud B. Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury Journal of Molecular Medicine. 90: 637-647. PMID 22246130 DOI: 10.1007/S00109-012-0859-2  0.274
2009 Fontán-Lozano A, Romero-Granados R, del-Pozo-Martín Y, Suárez-Pereira I, Delgado-García JM, Penninger JM, Carrión AM. Lack of DREAM protein enhances learning and memory and slows brain aging. Current Biology : Cb. 19: 54-60. PMID 19110430 DOI: 10.1016/J.Cub.2008.11.056  0.274
2003 Penninger JM, Kroemer G. Mitochondria, AIF and caspases--rivaling for cell death execution. Nature Cell Biology. 5: 97-9. PMID 12563272 DOI: 10.1038/Ncb0203-97  0.274
2012 Singer D, Camargo SM, Ramadan T, Schäfer M, Mariotta L, Herzog B, Huggel K, Wolfer D, Werner S, Penninger JM, Verrey F. Defective intestinal amino acid absorption in Ace2 null mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G686-95. PMID 22790597 DOI: 10.1152/Ajpgi.00140.2012  0.274
2015 Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, ... ... Penninger JM, et al. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 86: 1393-406. PMID 26087165 DOI: 10.1016/J.Neuron.2015.05.033  0.273
2020 Inoue M, Hada K, Shiraishi H, Yatsuka H, Fujinami H, Morisaki I, Nishida Y, Matsubara E, Ishitani T, Hanada R, Matsumoto M, Penninger JM, Ihara K, Hanada T. Tyrosine pre-transfer RNA fragments are linked to p53-dependent neuronal cell death via PKM2. Biochemical and Biophysical Research Communications. PMID 32143824 DOI: 10.1016/J.Bbrc.2020.02.157  0.273
2016 Openshaw RL, Thomson DM, Penninger JM, Pratt JA, Morris BJ. Mice haploinsufficient for Map2k7, a gene involved in neurodevelopment and risk for schizophrenia, show impaired attention, a vigilance decrement deficit and unstable cognitive processing in an attentional task: impact of minocycline. Psychopharmacology. PMID 27774567 DOI: 10.1007/S00213-016-4463-Y  0.273
2018 Sasaki F, Koga T, Ohba M, Saeki K, Okuno T, Ishikawa K, Nakama T, Nakao S, Yoshida S, Ishibashi T, Ahmadieh H, Kanavi MR, Hafezi-Moghadam A, Penninger JM, Sonoda KH, et al. Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. Jci Insight. 3. PMID 30232269 DOI: 10.1172/Jci.Insight.96902  0.273
1999 Lorenzo HK, Susin SA, Penninger J, Kroemer G. Apoptosis inducing factor (AIF): a phylogenetically old, caspase-independent effector of cell death. Cell Death and Differentiation. 6: 516-24. PMID 10381654 DOI: 10.1038/Sj.Cdd.4400527  0.272
2011 Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Penninger JM, Takayanagi H. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nature Medicine. 17: 1231-4. PMID 21909105 DOI: 10.1038/Nm.2452  0.272
1999 Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, et al. Molecular characterization of mitochondrial apoptosis-inducing factor. Nature. 397: 441-6. PMID 9989411 DOI: 10.1038/17135  0.272
2010 Awad AE, Kandalam V, Chakrabarti S, Wang X, Penninger JM, Davidge ST, Oudit GY, Kassiri Z. Tumor necrosis factor induces matrix metalloproteinases in cardiomyocytes and cardiofibroblasts differentially via superoxide production in a PI3Kgamma-dependent manner. American Journal of Physiology. Cell Physiology. 298: C679-92. PMID 20007453 DOI: 10.1152/Ajpcell.00351.2009  0.272
2013 Perlot T, Penninger JM. ACE2 - from the renin-angiotensin system to gut microbiota and malnutrition. Microbes and Infection / Institut Pasteur. 15: 866-73. PMID 23962453 DOI: 10.1016/J.Micinf.2013.08.003  0.271
2005 Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, Yang P, Sarao R, Wada T, Leong-Poi H, Crackower MA, Fukamizu A, Hui CC, Hein L, Uhlig S, ... ... Penninger JM, et al. Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature. 436: 112-6. PMID 16001071 DOI: 10.1038/Nature03712  0.271
2005 Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, ... ... Penninger JM, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nature Medicine. 11: 875-9. PMID 16007097 DOI: 10.1038/Nm1267  0.271
2003 Roumier T, Vieira HL, Castedo M, Ferri KF, Boya P, Andreau K, Druillennec S, Joza N, Penninger JM, Roques B, Kroemer G. The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway. Cell Death and Differentiation. 9: 1212-9. PMID 12404120 DOI: 10.1038/Sj.Cdd.4401089  0.27
2013 Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, ... ... Penninger JM, et al. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 495: 474-80. PMID 23474986 DOI: 10.1038/Nature11923  0.27
2002 Penninger JM, Woodgett J. Stem cells. PTEN--coupling tumor suppression to stem cells? Science (New York, N.Y.). 294: 2116-8. PMID 11739945 DOI: 10.1126/Science.1067931  0.27
2000 Ferri KF, Jacotot E, Blanco J, Esté JA, Zamzami N, Susin SA, Xie Z, Brothers G, Reed JC, Penninger JM, Kroemer G. Apoptosis control in syncytia induced by the HIV type 1-envelope glycoprotein complex: role of mitochondria and caspases. The Journal of Experimental Medicine. 192: 1081-92. PMID 11034598 DOI: 10.1084/Jem.192.8.1081  0.269
2020 Monteil V, Kwon H, Prado P, Hagelkrüys A, Wimmer RA, Stahl M, Leopoldi A, Garreta E, Hurtado Del Pozo C, Prosper F, Romero JP, Wirnsberger G, Zhang H, Slutsky AS, Conder R, ... ... Penninger JM, et al. Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2. Cell. PMID 32333836 DOI: 10.1016/J.Cell.2020.04.004  0.269
2015 Lempradl A, Pospisilik JA, Penninger JM. Exploring the emerging complexity in transcriptional regulation of energy homeostasis. Nature Reviews. Genetics. 16: 665-81. PMID 26460345 DOI: 10.1038/Nrg3941  0.269
2010 Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, Loibner H, Wang XH, Penninger JM, Kassiri Z, Oudit GY. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 122: 717-28, 18 p followi. PMID 20679547 DOI: 10.1161/Circulationaha.110.955369  0.269
2020 Orthofer M, Valsesia A, Mägi R, Wang QP, Kaczanowska J, Kozieradzki I, Leopoldi A, Cikes D, Zopf LM, Tretiakov EO, Demetz E, Hilbe R, Boehm A, Ticevic M, Nõukas M, ... ... Penninger JM, et al. Identification of ALK in Thinness. Cell. PMID 32442405 DOI: 10.1016/J.Cell.2020.04.034  0.267
2012 Winchester CL, Ohzeki H, Vouyiouklis DA, Thompson R, Penninger JM, Yamagami K, Norrie JD, Hunter R, Pratt JA, Morris BJ. Converging evidence that sequence variations in the novel candidate gene MAP2K7 (MKK7) are functionally associated with schizophrenia. Human Molecular Genetics. 21: 4910-21. PMID 22899651 DOI: 10.1093/Hmg/Dds331  0.267
2020 Bravo-Caparrós I, Ruiz-Cantero MC, Perazzoli G, Cronin SJF, Vela JM, Hamed MF, Penninger JM, Baeyens JM, Cobos EJ, Nieto FR. Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32157739 DOI: 10.1096/Fj.201901921R  0.267
2020 Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y. Sclerostin expression in trabecular bone is downregulated by osteoclasts. Scientific Reports. 10: 13751. PMID 32792620 DOI: 10.1038/S41598-020-70817-1  0.266
2010 Jin R, Yu S, Song Z, Quillin JW, Deasis DP, Penninger JM, Nanda A, Granger DN, Li G. Phosphoinositide 3-kinase-gamma expression is upregulated in brain microglia and contributes to ischemia-induced microglial activation in acute experimental stroke Biochemical and Biophysical Research Communications. 399: 458-464. PMID 20678469 DOI: 10.1016/J.Bbrc.2010.07.116  0.266
2000 Daugas E, Susin SA, Zamzami N, Ferri KF, Irinopoulou T, Larochette N, Prévost MC, Leber B, Andrews D, Penninger J, Kroemer G. Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis Faseb Journal. 14: 729-739. PMID 10744629 DOI: 10.1096/Fasebj.14.5.729  0.266
2011 Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U, Goodall AH, Labrune Y, Lopez LM, Mägi R, Meacham S, Okada Y, Pirastu N, ... ... Penninger J, et al. New gene functions in megakaryopoiesis and platelet formation. Nature. 480: 201-8. PMID 22139419 DOI: 10.1038/Nature10659  0.266
2011 Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM. TrpA1 regulates thermal nociception in Drosophila. Plos One. 6: e24343. PMID 21909389 DOI: 10.1371/Journal.Pone.0024343  0.264
2015 Dufresne SS, Dumont NA, Bouchard P, Lavergne É, Penninger JM, Frenette J. Osteoprotegerin protects against muscular dystrophy. The American Journal of Pathology. 185: 920-6. PMID 25708645 DOI: 10.1016/J.Ajpath.2015.01.006  0.264
2014 Zhong J, Jin H, Yu X, Zhang Z, Yu H, Chen L, Xu Y, Song B, Penninger JM, Gao P, Oudit GY. GW25-e1527 Cardioprotective Effects of Angiotensin-Converting Enzyme 2 in Apolipoprotein E-Deficient Mice in Response to Angiotensin II Journal of the American College of Cardiology. 64: C1. DOI: 10.1016/J.Jacc.2014.06.017  0.264
1997 Bachmaier K, Pummerer C, Kozieradzki I, Pfeffer K, Mak TW, Neu N, Penninger JM. Low-molecular-weight tumor necrosis factor receptor p55 controls induction of autoimmune heart disease. Circulation. 95: 655-61. PMID 9024154 DOI: 10.1161/01.Cir.95.3.655  0.264
2017 Andergassen D, Dotter CP, Wenzel D, Sigl V, Bammer PC, Muckenhuber M, Mayer D, Kulinski TM, Theussl H, Penninger JM, Bock C, Barlow DP, Pauler FM, Hudson QJ. Author response: Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression Elife. DOI: 10.7554/Elife.25125.024  0.263
2012 Attané C, Foussal C, Le Gonidec S, Benani A, Daviaud D, Wanecq E, Guzmán-Ruiz R, Dray C, Bezaire V, Rancoule C, Kuba K, Ruiz-Gayo M, Levade T, Penninger J, Burcelin R, et al. Apelin treatment increases complete Fatty Acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes. 61: 310-20. PMID 22210322 DOI: 10.2337/Db11-0100  0.262
2019 Uribesalgo I, Hoffmann D, Zhang Y, Kavirayani A, Lazovic J, Berta J, Novatchkova M, Pai TP, Wimmer RA, László V, Schramek D, Karim R, Tortola L, Deswal S, Haas L, ... ... Penninger JM, et al. Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. Embo Molecular Medicine. e9266. PMID 31267692 DOI: 10.15252/Emmm.201809266  0.262
2019 Fujiwara S, Hoshizaki M, Ichida Y, Lex D, Kuroda E, Ishii KJ, Magi S, Okada M, Takao H, Gandou M, Imai H, Hara R, Herzog H, Yoshimura A, Okamura H, ... Penninger JM, et al. Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection. Nature Microbiology. 4: 258-268. PMID 30455472 DOI: 10.1038/S41564-018-0289-1  0.261
2006 Fischer L, Gukovskaya AS, Penninger JM, Mareninova OA, Friess H, Gukovsky I, Pandol SJ. Phosphatidylinositol 3-kinase facilitates bile acid-induced Ca(2+) responses in pancreatic acinar cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G875-86. PMID 17158252 DOI: 10.1152/Ajpgi.00558.2005  0.261
2008 Garabelli PJ, Modrall JG, Penninger JM, Ferrario CM, Chappell MC. Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart Experimental Physiology. 93: 613-621. PMID 18356559 DOI: 10.1113/Expphysiol.2007.040246  0.261
2017 Andergassen D, Dotter CP, Wenzel D, Sigl V, Bammer PC, Muckenhuber M, Mayer D, Kulinski TM, Theussl HC, Penninger JM, Bock C, Barlow DP, Pauler FM, Hudson QJ. Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. Elife. 6. PMID 28806168 DOI: 10.7554/Elife.25125  0.26
2010 Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, ... ... Penninger JM, et al. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Cell. 143: 628-38. PMID 21074052 DOI: 10.1016/J.Cell.2010.09.047  0.26
2006 Imai Y, Kuba K, Penninger JM. The renin-angiotensin system in acute respiratory distress syndrome Drug Discovery Today: Disease Mechanisms. 3: 225-229. DOI: 10.1016/J.Ddmec.2006.06.012  0.26
1999 Penninger JM, Crabtree GR. The actin cytoskeleton and lymphocyte activation. Cell. 96: 9-12. PMID 9989492 DOI: 10.1016/S0092-8674(00)80954-X  0.26
1999 Irwin MW, Woodgett JR, Penninger J, Parker T, Lu C, Liu P. TNF-α and IL-1β activate p38 mitogen-activated and C-jun N-terminal kinase signaling cascades in myocytes, and interacts with free radicals Journal of Cardiac Failure. 5: 21. DOI: 10.1016/S1071-9164(99)91418-5  0.258
2016 Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kühn B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nature Protocols. 11: 542-52. PMID 26890681 DOI: 10.1038/Nprot.2016.031  0.258
2006 Kuba K, Imai Y, Penninger JM. Angiotensin-converting enzyme 2 in lung diseases. Current Opinion in Pharmacology. 6: 271-6. PMID 16581295 DOI: 10.1016/J.Coph.2006.03.001  0.257
2019 Wimmer RA, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, Taubenschmid J, Hämmerle M, Esk C, Bagley JA, Lindenhofer D, Chen G, Boehm M, Agu CA, Yang F, ... ... Penninger JM, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. PMID 30651639 DOI: 10.1038/S41586-018-0858-8  0.257
2018 Stephen J, Nampoothiri S, Banerjee A, Tolman NJ, Penninger JM, Elling U, Agu CA, Burke JD, Devadathan K, Kannan R, Huang Y, Steinbach PJ, Martinis SA, Gahl WA, Malicdan MCV. Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy. Human Genetics. PMID 29691655 DOI: 10.1007/S00439-018-1882-3  0.256
2017 Rao S, Sigl V, Wimmer RA, Novatchkova M, Jais A, Wagner G, Handschuh S, Uribesalgo I, Hagelkruys A, Kozieradzki I, Tortola L, Nitsch R, Cronin SJ, Orthofer M, Branstetter D, ... ... Penninger JM, et al. RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes & Development. PMID 29118048 DOI: 10.1101/Gad.304162.117  0.256
2004 Eriksson U, Kopf M, Afanasyeva M, Penninger JM. Models of autoimmune heart disease Drug Discovery Today: Disease Models. 1: 411-416. DOI: 10.1016/J.Ddmod.2004.11.015  0.255
2016 Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, ... ... Penninger JM, et al. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research. PMID 27241552 DOI: 10.1038/Cr.2016.69  0.255
2016 Haubner BJ, Schuetz T, Penninger JM. A reproducible protocol for neonatal ischemic injury and cardiac regeneration in neonatal mice. Basic Research in Cardiology. 111: 64. PMID 27665606 DOI: 10.1007/S00395-016-0580-3  0.254
2005 Kolas NK, Marcon E, Crackower MA, Höög C, Penninger JM, Spyropoulos B, Moens PB. Mutant meiotic chromosome core components in mice can cause apparent sexual dimorphic endpoints at prophase or X-Y defective male-specific sterility. Chromosoma. 114: 92-102. PMID 15983832 DOI: 10.1007/S00412-005-0334-8  0.254
2004 Cheng HY, Penninger JM. DREAMing about arthritic pain. Annals of the Rheumatic Diseases. ii72-ii75. PMID 15479877 DOI: 10.1136/Ard.2004.029942  0.253
2015 Weitzer S, Hanada T, Penninger JM, Martinez J. CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders. Wiley Interdisciplinary Reviews. Rna. 6: 47-63. PMID 25142875 DOI: 10.1002/Wrna.1255  0.252
2013 Lancaster MA, Renner M, Martin CA, Wenzel D, Bicknell LS, Hurles ME, Homfray T, Penninger JM, Jackson AP, Knoblich JA. Cerebral organoids model human brain development and microcephaly. Nature. 501: 373-9. PMID 23995685 DOI: 10.1038/Nature12517  0.252
2002 Sun M, Dawood F, Wen W, Penninger J, Liu P. Excessive tumour necrosis factor activation post-infarction contributes to the early susceptibility to myocardial rupture: evidence From TNF-/- transgenic knockout models Journal of the American College of Cardiology. 39: 338. DOI: 10.1016/S0735-1097(02)81521-2  0.251
2009 Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, Scholey JW, Penninger JM, Oudit GY. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circulation. Heart Failure. 2: 446-55. PMID 19808375 DOI: 10.1161/Circheartfailure.108.840124  0.251
2020 Zhang H, Penninger JM, Li Y, Zhong N, Slutsky AS. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Medicine. PMID 32125455 DOI: 10.1007/S00134-020-05985-9  0.25
2015 Kulinski TM, Casari MR, Guenzl PM, Wenzel D, Andergassen D, Hladik A, Datlinger P, Farlik M, Theussl HC, Penninger JM, Knapp S, Bock C, Barlow DP, Hudson QJ. Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Developmental Biology. 402: 291-305. PMID 25912690 DOI: 10.1016/J.Ydbio.2015.04.010  0.249
2015 Sun Y, Guo F, Zou Z, Li C, Hong X, Zhao Y, Wang C, Wang H, Liu H, Yang P, Han Z, Liu K, Kuba K, Song B, Gao J, ... ... Penninger JM, et al. Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice. Particle and Fibre Toxicology. 12: 4. PMID 25890286 DOI: 10.1186/S12989-015-0080-X  0.249
2012 Zhong J, Song B, Jin H, Xu Y, Kassiri Z, Zhang Z, Gao P, Penninger JM, Oudit GY, Zhong J. ANGIOTENSIN II-MEDIATED MYOCARDIAL EXPRESSION OF MMP2, MMP9 AND MT1-MMP WERE ENHANCED IN ACE2-NULL MICE Heart. 98: E9.2-E9. DOI: 10.1136/Heartjnl-2012-302920A.19  0.249
2016 Kiechl S, Schramek D, Widschwendter M, Fourkala EO, Zaikin A, Jones A, Jaeger B, Rack B, Janni W, Scholz C, Willeit J, Weger S, Mayr A, Teschendorff A, Rosenthal A, ... ... Penninger JM, et al. Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer. Oncotarget. PMID 28002811 DOI: 10.18632/Oncotarget.14013  0.248
2017 Sato T, Watanabe H, Yamaguchi T, Kimura A, Fukamizu A, Penninger J, Bruno R, Ito H, Imai Y, Kuba K. ELABELA, a Novel APJ Ligand, Inhibits Pressure Overload- and Angiotensin II-induced Cardiac Remodeling Journal of Cardiac Failure. 23: S56. DOI: 10.1016/J.Cardfail.2017.08.272  0.248
2015 Haubner BJ, Schneider J, Schweigmann UU, Schuetz T, Dichtl W, Velik-Salchner C, Stein JI, Penninger JM. Functional Recovery of a Human Neonatal Heart After Severe Myocardial Infarction. Circulation Research. PMID 26659640 DOI: 10.1161/Circresaha.115.307017  0.248
2011 Schramek D, Penninger JM. The many roles of RANKL-RANK signaling in bone, breast and cancer Ibms Bonekey. 8: 237-256. DOI: 10.1138/20110512  0.247
2007 Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kahn CR, Kroemer G, Rustin P, ... ... Penninger JM, et al. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell. 131: 476-91. PMID 17981116 DOI: 10.1016/J.Cell.2007.08.047  0.246
2017 Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, ... ... Penninger JM, et al. Molecular definitions of autophagy and related processes. The Embo Journal. PMID 28596378 DOI: 10.15252/Embj.201796697  0.246
2009 Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Response to Angiotensinconverting enzyme 2 (ACE2) gene and protein expression in diabetic patients without nephropathy Kidney International. 75: 1119. DOI: 10.1038/Ki.2009.47  0.246
2018 Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, et al. Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Reports. 25: 383-397.e10. PMID 30304679 DOI: 10.1016/J.Celrep.2018.09.034  0.245
2019 Andergassen D, Muckenhuber M, Bammer PC, Kulinski TM, Theussl HC, Shimizu T, Penninger JM, Pauler FM, Hudson QJ. The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. Plos Genetics. 15: e1008268. PMID 31329595 DOI: 10.1371/Journal.Pgen.1008268  0.245
2011 Jin H, Zhong J, Song B, Oudit GY, Li Y, Schuster M, Zhu D, Gao P, Loibner H, Penninger JM. ACE2 is a negative regulator of profilin-1 expression and collagen production in cultured adult murine cardiomyocytes International Journal of Cardiology. 152: S99. DOI: 10.1016/J.Ijcard.2011.08.794  0.245
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