| Year |
Citation |
Score |
| 2023 |
Zhou Y, Mowlazadeh Haghighi S, Sawyer JR, Hruby VJ, Cai M. Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH Lead to Potent and Selective Agonists at hMC1R and hMC4R. Journal of Medicinal Chemistry. 66: 6715-6724. PMID 37133411 DOI: 10.1021/acs.jmedchem.2c01794 |
0.693 |
|
| 2022 |
Tomassi S, Dimmito MP, Cai M, D'Aniello A, Del Bene A, Messere A, Liu Z, Zhu T, Hruby VJ, Stefanucci A, Cosconati S, Mollica A, Di Maro S. CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. Journal of Medicinal Chemistry. PMID 35188390 DOI: 10.1021/acs.jmedchem.1c01848 |
0.688 |
|
| 2021 |
Mehr-Un-Nisa, Munawar MA, Rankin D, Hruby VJ, Porreca F, Lee YS. C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. Bioorganic & Medicinal Chemistry. 51: 116509. PMID 34798381 DOI: 10.1016/j.bmc.2021.116509 |
0.374 |
|
| 2021 |
Zhou Y, Chawla MK, Rios-Monterrosa JL, Wang L, Zempare MA, Hruby VJ, Barnes CA, Cai M. Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions. Molecules (Basel, Switzerland). 26. PMID 34684847 DOI: 10.3390/molecules26206266 |
0.58 |
|
| 2021 |
Keresztes A, Olson K, Nguyen P, Lopez-Pier MA, Hecksel R, Barker NK, Liu Z, Hruby V, Konhilas J, Langlais PR, Streicher JM. Antagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling. Pain. PMID 34252907 DOI: 10.1097/j.pain.0000000000002320 |
0.813 |
|
| 2021 |
Lee YS, Remesic M, Ramos-Colon C, Wu Z, LaVigne J, Molnar G, Tymecka D, Misicka A, Streicher JM, Hruby VJ, Porreca F. Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism. Biomedicines. 9. PMID 34072734 DOI: 10.3390/biomedicines9060625 |
0.656 |
|
| 2021 |
Kondrashov M, Svensson SPS, Ström P, Westermark A, Jacobson-Ingemyr H, Takano A, Tari L, Tóth M, Cai M, Hruby VJ, Schou M. Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma. Bioconjugate Chemistry. PMID 33576604 DOI: 10.1021/acs.bioconjchem.0c00671 |
0.601 |
|
| 2020 |
Zhou Y, Mowlazadeh Haghighi S, Liu Z, Wang L, Hruby VJ, Cai M. Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor. Acs Pharmacology & Translational Science. 3: 921-930. PMID 33073191 DOI: 10.1021/acsptsci.0c00072 |
0.607 |
|
| 2020 |
Kadiri JJ, Thapa K, Kaipio K, Cai M, Hruby VJ, Rinne P. Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. European Journal of Pharmacology. 173186. PMID 32416182 DOI: 10.1016/J.Ejphar.2020.173186 |
0.661 |
|
| 2020 |
Gao F, Handl H, Vagner J, Hruby V, Gillies R. Convenient and Efficient Synthesis of a Lanthanide-Coordinated, Diethylene Triamine Pentaacetic Acid Labeled Biopolymer as an Assay for the Cholecystokinin B Receptor. Journal of Applied Polymer Science. Applied Polymer Symposium. 106: 2683-2688. PMID 19562042 DOI: 10.1002/App.26910 |
0.427 |
|
| 2019 |
Wu Z, Hruby VJ. Toward a Universal μ-Agonist Template for Template-Based Alignment Modeling of Opioid Ligands. Acs Omega. 4: 17457-17476. PMID 31656918 DOI: 10.1021/acsomega.9b02244 |
0.316 |
|
| 2019 |
Zhou Y, Banday AH, Hruby VJ, Cai M. Development of -Acetylated Dipalmitoyl--Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists. Molecules (Basel, Switzerland). 24. PMID 31569697 DOI: 10.3390/Molecules24193512 |
0.624 |
|
| 2019 |
Hruby VJ. Multivalent Peptide and Peptidomimetic Ligands for the Treatment of Pain without Toxicities and Addiction. Peptides. PMID 31014958 DOI: 10.1016/J.Peptides.2019.02.004 |
0.334 |
|
| 2018 |
Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Correction to Design of MC1R Selective γ-MSH Analogues with Canonical Amino Acids Leads to Potency and Pigmentation. Journal of Medicinal Chemistry. PMID 30252463 DOI: 10.1021/Acs.Jmedchem.8B01423 |
0.656 |
|
| 2018 |
Eerola K, Virtanen S, Vähätalo L, Ailanen L, Cai M, Hruby V, Savontaus M, Savontaus E. Hypothalamic γ-melanocyte stimulating hormone gene delivery reduces fat mass in male mice. The Journal of Endocrinology. PMID 30006340 DOI: 10.1530/Joe-18-0009 |
0.607 |
|
| 2018 |
Olson KM, Keresztes A, Tashiro JK, Daconta LV, Hruby VJ, Streicher JM. Synthesis and Evaluation of a Novel Bivalent Selective Antagonist for the Mu-Delta Opioid Receptor Heterodimer that Reduces Morphine Withdrawal in Mice. Journal of Medicinal Chemistry. PMID 29939746 DOI: 10.1021/Acs.Jmedchem.8B00403 |
0.829 |
|
| 2018 |
Remesic M, Macedonio G, Mollica A, Porreca F, Hruby V, Lee YS. Cyclic biphalin analogues with a novel linker lead to potent agonist activities at mu, delta, and kappa opioid receptors. Bioorganic & Medicinal Chemistry. PMID 29858157 DOI: 10.1016/J.Bmc.2018.05.045 |
0.474 |
|
| 2018 |
Mowlazadeh Haghighi S, Zhou Y, Dai J, Sawyer JR, Hruby VJ, Cai M. Replacement of Arg with Nle and modified D-Phe in the core sequence of MSHs, Ac-His-D-Phe-Arg-Trp-NH, leads to hMC1R selectivity and pigmentation. European Journal of Medicinal Chemistry. 151: 815-823. PMID 29679901 DOI: 10.1016/J.Ejmech.2018.04.021 |
0.686 |
|
| 2018 |
Merlino F, Zhou Y, Cai M, Carotenuto A, Yousif AM, Brancaccio D, Di Maro S, Zappavigna S, Limatola A, Novellino E, Grieco P, Hruby VJ. Development of Macrocyclic Peptidomimetics Containing Constrained α,α-Dialkylated Amino Acids with Potent and Selective Activity at Human Melanocortin Receptors. Journal of Medicinal Chemistry. PMID 29660981 DOI: 10.1021/Acs.Jmedchem.8B00488 |
0.718 |
|
| 2018 |
Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, ... ... Hruby VJ, et al. Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. Journal of Medicinal Chemistry. PMID 29605997 DOI: 10.1021/Acs.Jmedchem.8B00170 |
0.695 |
|
| 2017 |
Zhou Y, Mowlazadeh Haghighi S, Zoi I, Sawyer JR, Hruby VJ, Cai M. Design of MC1R selective γ-MSH analogues with canonical amino acids leads to potency and pigmentation. Journal of Medicinal Chemistry. PMID 29094944 DOI: 10.1021/Acs.Jmedchem.7B01295 |
0.724 |
|
| 2017 |
Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, McIntosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain. Journal of Heterocyclic Chemistry. 54: 1228-1235. PMID 28819330 DOI: 10.1002/Jhet.2696 |
0.786 |
|
| 2017 |
Cai M, Marelli UK, Mertz B, Beck JG, Opperer F, Rechenmacher F, Kessler H, Hruby VJ. Structural Insights into Selective Ligand-Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists. Biochemistry. PMID 28715181 DOI: 10.1021/Acs.Biochem.7B00407 |
0.732 |
|
| 2017 |
Stefanucci A, Lei W, Hruby VJ, Macedonio G, Luisi G, Carradori S, Streicher JM, Mollica A. Fluorescent-labeled bioconjugates of the opioid peptides biphalin and DPDPE incorporating fluorescein-maleimide linkers. Future Medicinal Chemistry. PMID 28635314 DOI: 10.4155/Fmc-2016-0232 |
0.657 |
|
| 2017 |
Sandweiss AJ, McIntosh MI, Moutal A, Davidson-Knapp R, Hu J, Giri AK, Yamamoto T, Hruby VJ, Khanna R, Largent-Milnes TM, Vanderah TW. Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential. Molecular Psychiatry. PMID 28485408 DOI: 10.1038/Mp.2017.102 |
0.737 |
|
| 2017 |
Rinne P, Rami M, Nuutinen SL, Santovito D, van der Vorst EPC, Guillamat-Prats R, Lyytikäinen LP, Raitoharju E, Oksala N, Ring L, Cai M, Hruby VJ, Lehtimäki TJ, Weber C, Steffens S. Melanocortin 1 Receptor Signaling Regulates Cholesterol Transport in Macrophages. Circulation. PMID 28450348 DOI: 10.1161/Circulationaha.116.025889 |
0.616 |
|
| 2017 |
Remesic MV, Hruby VJ, Porreca F, Lee YS. Recent Advances in the Realm of Allosteric Modulators for the Opioid Receptors for Future Therapeutics. Acs Chemical Neuroscience. PMID 28368571 DOI: 10.1021/Acschemneuro.7B00090 |
0.454 |
|
| 2016 |
Ramos-Colon CN, Lee YS, Remesic MV, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher JM, Porreca F, Hruby VJ. Structure Activity Relationships of [des-Arg(7)]- Dynorphin A Analogues at the Kappa Opioid Receptor. Journal of Medicinal Chemistry. PMID 27797517 DOI: 10.1021/Acs.Jmedchem.6B01411 |
0.811 |
|
| 2016 |
Lee YS, Remesic M, Ramos-Colon C, Hall SM, Kuzmin A, Rankin D, Porreca F, Lai J, Hruby VJ. Cyclic non-opioid dynorphin A analogues for the bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. PMID 27756562 DOI: 10.1016/J.Bmcl.2016.10.010 |
0.434 |
|
| 2016 |
Hall SM, LeBaron L, Ramos-Colon CN, Qu C, Xie JY, Porreca F, Lai J, Lee YS, Hruby VJ. Discovery of Stable Non-opioid Dynorphin A Analogues Interacting at the Bradykinin Receptors for the Treatment of Neuropathic Pain. Acs Chemical Neuroscience. PMID 27619237 DOI: 10.1021/Acschemneuro.6B00258 |
0.478 |
|
| 2016 |
Cai M, Hruby VJ. Design of Cyclized Selective Melanotropins. Biopolymers. PMID 27561155 DOI: 10.1002/Bip.22976 |
0.695 |
|
| 2016 |
Hruby VJ. Design of Cyclic Peptides with Biological Activities from Biologically Active Peptides: The Case of Peptide Modulators of Melanocortin Receptors. Biopolymers. PMID 27486849 DOI: 10.1002/Bip.22929 |
0.378 |
|
| 2016 |
Lee YS, Kupp R, Remesic M, Ramos-Colon C, Hall SM, Chan C, Rankin D, Lai J, Porreca F, Hruby VJ. Various modifications of the amphipathic dynorphin A phamacophore for rat brain bradykinin receptors. Chemical Biology & Drug Design. PMID 27203574 DOI: 10.1111/Cbdd.12789 |
0.436 |
|
| 2016 |
Remesic M, Lee YS, Hruby VJ. Cyclic Opioid Peptides. Current Medicinal Chemistry. PMID 27117332 DOI: 10.2174/0929867323666160427123005 |
0.478 |
|
| 2016 |
Cai M, Hruby VJ. The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases. Current Protein & Peptide Science. PMID 26916163 DOI: 10.2174/1389203717666160226145330 |
0.732 |
|
| 2016 |
Hruby VJ. Conformational and dynamic considerations in drug design for G-protein coupled receptors Medicinal Chemistry. 6. DOI: 10.4172/2161-0444.C1.026 |
0.316 |
|
| 2016 |
Vardanyan RS, Cain JP, Haghighi SM, Kumirov VK, Mcintosh MI, Sandweiss AJ, Porreca F, Hruby VJ. Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain Journal of Heterocyclic Chemistry. DOI: 10.1002/jhet.2696 |
0.691 |
|
| 2015 |
Huynh AS, Estrella V, Stark VE, Cohen AS, Chen T, Casagni TJ, Josan JS, Lloyd MC, Johnson J, Kim J, Hruby VJ, Vagner J, Morse DL. Tumor Targeting and Pharmacokinetics of a Near Infrared Fluorescent-labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5. Molecular Pharmaceutics. PMID 26713599 DOI: 10.1021/Acs.Molpharmaceut.5B00760 |
0.729 |
|
| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Vanderah TW, Porecca F, Hruby VJ. Design synthesis and structure-activity relationship of 5-substituted (tetrahydronaphthalen-2yl)methyl with N-phenyl-N-(piperidin-2-yl)propionamide derivatives as opioid ligands. Bioorganic & Medicinal Chemistry. PMID 26712115 DOI: 10.1016/J.Bmc.2015.11.030 |
0.842 |
|
| 2015 |
Deekonda S, Cole J, Sunna S, Rankin D, Largent-Milnes TM, Davis P, BassiriRad NM, Lai J, Vanderah TW, Porecca F, Hruby VJ. Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations. Bioorganic & Medicinal Chemistry Letters. PMID 26611918 DOI: 10.1016/J.Bmcl.2015.10.081 |
0.838 |
|
| 2015 |
Carotenuto A, Merlino F, Cai M, Brancaccio D, Yousif AM, Novellino E, Hruby VJ, Grieco P. Discovery of Novel Potent and Selective Agonists at the Melanocortin‑3 Receptor. Journal of Medicinal Chemistry. PMID 26599352 DOI: 10.1021/Acs.Jmedchem.5B01285 |
0.714 |
|
| 2015 |
Giri AK, Apostol CR, Wang Y, Forte BL, Largent-Milnes TM, Davis P, Rankin D, Molnar G, Olson KM, Porreca F, Vanderah TW, Hruby VJ. Discovery of Novel Multifunctional Ligands with μ/δ Opioid Agonist/Neurokinin-1 (NK1) Antagonist Activities for the Treatment of Pain. Journal of Medicinal Chemistry. PMID 26465170 DOI: 10.1021/Acs.Jmedchem.5B01170 |
0.834 |
|
| 2015 |
Shukla C, Koch LG, Britton SL, Cai M, Hruby VJ, Bednarek M, Novak CM. Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats. Neuroscience. PMID 26404873 DOI: 10.1016/J.Neuroscience.2015.09.035 |
0.656 |
|
| 2015 |
Deekonda S, Wugalter L, Rankin D, Largent-Milnes TM, Davis P, Wang Y, Bassirirad NM, Lai J, Kulkarni V, Vanderah TW, Porreca F, Hruby VJ. Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 26323872 DOI: 10.1016/J.Bmcl.2015.07.064 |
0.841 |
|
| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors. Bioorganic & Medicinal Chemistry Letters. 25: 4148-52. PMID 26316468 DOI: 10.1016/J.Bmcl.2015.08.014 |
0.84 |
|
| 2015 |
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. Bioorganic & Medicinal Chemistry. 23: 6185-94. PMID 26299827 DOI: 10.1016/J.Bmc.2015.07.071 |
0.838 |
|
| 2015 |
Lee YS, Hall SM, Ramos-Colon C, Remesic M, Rankin D, Vanderah TW, Porreca F, Lai J, Hruby VJ. Blockade of non-opioid excitatory effects of spinal dynorphin A at bradykinin receptors. Receptors & Clinical Investigation. 2. PMID 26221618 DOI: 10.14800/Rci.517 |
0.426 |
|
| 2015 |
Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors. Journal of Medicinal Chemistry. 58: 6359-67. PMID 26218460 DOI: 10.1021/Acs.Jmedchem.5B00102 |
0.731 |
|
| 2015 |
Nair P, Yamamoto T, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Discovery of tripeptide-derived multifunctional ligands possessing delta/mu opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 25: 3716-20. PMID 26212775 DOI: 10.1016/J.Bmcl.2015.06.030 |
0.783 |
|
| 2015 |
Mehr-un-Nisa, Munawar MA, Lee YS, Rankin D, Munir J, Lai J, Khan MA, Hruby VJ. Design, synthesis, and biological evaluation of a series of bifunctional ligands of opioids/SSRIs. Bioorganic & Medicinal Chemistry. 23: 1251-9. PMID 25703306 DOI: 10.1016/J.Bmc.2015.01.047 |
0.483 |
|
| 2015 |
Van der Poorten O, Fehér K, Buysse K, Feytens D, Zoi I, Schwartz SD, Martins JC, Tourwé D, Cai M, Hruby VJ, Ballet S. Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist. Acs Medicinal Chemistry Letters. 6: 192-7. PMID 25699148 DOI: 10.1021/Ml500436S |
0.715 |
|
| 2015 |
Bird MF, Vardanyan RS, Hruby VJ, Calò G, Guerrini R, Salvadori S, Trapella C, McDonald J, Rowbotham DJ, Lambert DG. Development and characterisation of novel fentanyl-delta opioid receptor antagonist based bivalent ligands. British Journal of Anaesthesia. 114: 646-56. PMID 25680364 DOI: 10.1093/bja/aeu454 |
0.704 |
|
| 2015 |
Lee YS, Hall SM, Ramos-Colon C, Remesic M, LeBaron L, Nguyen A, Rankin D, Porreca F, Lai J, Hruby VJ. Modification of amphipathic non-opioid dynorphin A analogues for rat brain bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 25: 30-3. PMID 25434001 DOI: 10.1016/J.Bmcl.2014.11.026 |
0.355 |
|
| 2015 |
Banday AH, Kulkarni VV, Hruby VJ. Design, synthesis, and biological and docking studies of novel epipodophyllotoxin-chalcone hybrids as potential anticancer agents Medchemcomm. 6: 94-104. DOI: 10.1039/C4Md00325J |
0.701 |
|
| 2015 |
Cai M, Marelli UK, Bao J, Beck JG, Opperer F, Rechenmacher F, McLeod KR, Zingsheim MR, Doedens L, Kessler H, Hruby VJ. Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors Journal of Medicinal Chemistry. 58: 6359-6367. DOI: 10.1021/acs.jmedchem.5b00102 |
0.673 |
|
| 2015 |
Xu X, Struts AV, Giri AK, Molugu TR, Guruge C, Faylough S, Nascimento CL, Nesnas N, Hruby VJ, Brown MF. Solid-State 2H NMR Investigation of Transducin Activation by Rhodopsin Biophysical Journal. 108: 411a. DOI: 10.1016/J.Bpj.2014.11.2256 |
0.534 |
|
| 2015 |
Deekonda S, Rankin D, Davis P, Lai J, Porreca F, Hruby VJ. Design, synthesis and biological evaluation of multifunctional ligands targeting opioid and bradykinin 2 receptors Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.08.014 |
0.832 |
|
| 2015 |
Deekonda S, Wugalter L, Kulkarni V, Rankin D, Largent-Milnes TM, Davis P, Bassirirad NM, Lai J, Vanderah TW, Porreca F, Hruby VJ. Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands Bioorganic and Medicinal Chemistry. 23: 6185-6194. DOI: 10.1016/j.bmc.2015.07.071 |
0.814 |
|
| 2015 |
Mollica A, Stefanucci A, Costante R, Hruby VJ. Rational approach to the design of bioactive peptidomimetics: Recent developments in opioid agonist peptides Studies in Natural Products Chemistry. 46: 27-68. DOI: 10.1016/B978-0-444-63462-7.00002-6 |
0.458 |
|
| 2014 |
Fernandes SM, Lee YS, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent ligands for binding to the human melanocortin-4 receptor. Bioorganic & Medicinal Chemistry. 22: 6360-5. PMID 25438759 DOI: 10.1016/J.Bmc.2014.09.055 |
0.443 |
|
| 2014 |
Lee YS, Rankin D, Hall SM, Ramos-Colon C, Ortiz JJ, Kupp R, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of non-opioid [des-Arg(7)]-dynorphin A analogues for bradykinin receptors. Bioorganic & Medicinal Chemistry Letters. 24: 4976-9. PMID 25282551 DOI: 10.1016/J.Bmcl.2014.09.033 |
0.462 |
|
| 2014 |
Mollica A, Carotenuto A, Novellino E, Limatola A, Costante R, Pinnen F, Stefanucci A, Pieretti S, Borsodi A, Samavati R, Zador F, Benyhe S, Davis P, Porreca F, Hruby VJ. Novel cyclic biphalin analogue with improved antinociceptive properties. Acs Medicinal Chemistry Letters. 5: 1032-6. PMID 25221662 DOI: 10.1021/Ml500241N |
0.405 |
|
| 2014 |
Lee YS, Muthu D, Hall SM, Ramos-Colon C, Rankin D, Hu J, Sandweiss AJ, De Felice M, Xie JY, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of amphipathic dynorphin A analogues to inhibit the neuroexcitatory effects of dynorphin A through bradykinin receptors in the spinal cord. Journal of the American Chemical Society. 136: 6608-16. PMID 24742335 DOI: 10.1021/Ja501677Q |
0.402 |
|
| 2014 |
Vardanyan RS, Hruby VJ. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Medicinal Chemistry. 6: 385-412. PMID 24635521 DOI: 10.4155/Fmc.13.215 |
0.702 |
|
| 2014 |
Giri AK, Hruby VJ. Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain. Expert Opinion On Investigational Drugs. 23: 227-41. PMID 24329035 DOI: 10.1517/13543784.2014.856879 |
0.574 |
|
| 2014 |
Karthikeyan B, Giri A, Kulkarni V, Hruby V. Simple size-selective separation and microscopic characterization of Phe–Phe nanotubes and study of its internalization inside CHO cells Journal of Microscopy and Ultrastructure. 2: 224. DOI: 10.1016/J.Jmau.2014.10.002 |
0.755 |
|
| 2014 |
Karthikeyan B, Giri AK, Hruby VJ. Entrap and release of Phe–Phe nanotubes in sol–gel derived silicate matrix: study through nanosilver interaction Journal of Sol-Gel Science and Technology. 72: 534-542. DOI: 10.1007/S10971-014-3470-X |
0.539 |
|
| 2013 |
Lee YS, Qu HC, Davis P, Ma SW, Vardanyan R, Lai J, Porreca F, Hruby VJ. Chiral Effect of a Phe Residue in Position 3 of the Dmt(1)-L(or D)-Tic(2) Analogues on Opioid Functional Activities. Acs Medicinal Chemistry Letters. 4: 656-659. PMID 24648867 DOI: 10.1021/Ml400115N |
0.791 |
|
| 2013 |
Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6. PMID 24084045 DOI: 10.1016/J.Lfs.2013.09.016 |
0.764 |
|
| 2013 |
Nair P, Yamamoto T, Largent-Milnes TM, Cowell S, Kulkarni V, Moye S, Navratilova E, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities. Bioorganic & Medicinal Chemistry Letters. 23: 4975-8. PMID 23899615 DOI: 10.1016/J.Bmcl.2013.06.065 |
0.839 |
|
| 2013 |
Alleti R, Vagner J, Dehigaspitiya DC, Moberg VE, Elshan NG, Tafreshi NK, Brabez N, Weber CS, Lynch RM, Hruby VJ, Gillies RJ, Morse DL, Mash EA. Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors. Bioorganic & Medicinal Chemistry. 21: 5029-38. PMID 23890524 DOI: 10.1016/J.Bmc.2013.06.052 |
0.801 |
|
| 2013 |
Barkey NM, Preihs C, Cornnell HH, Martinez G, Carie A, Vagner J, Xu L, Lloyd MC, Lynch VM, Hruby VJ, Sessler JL, Sill KN, Gillies RJ, Morse DL. Development and in vivo quantitative magnetic resonance imaging of polymer micelles targeted to the melanocortin 1 receptor. Journal of Medicinal Chemistry. 56: 6330-8. PMID 23863078 DOI: 10.1021/Jm4005576 |
0.326 |
|
| 2013 |
Largent-Milnes TM, Brookshire SW, Skinner DP, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. The Journal of Pharmacology and Experimental Therapeutics. 347: 7-19. PMID 23860305 DOI: 10.1124/Jpet.113.205245 |
0.801 |
|
| 2013 |
Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Effect of anchoring 4-anilidopiperidines to opioid peptides. Bioorganic & Medicinal Chemistry Letters. 23: 3434-7. PMID 23623418 DOI: 10.1016/J.Bmcl.2013.03.065 |
0.802 |
|
| 2013 |
Mollica A, Pinnen F, Costante R, Locatelli M, Stefanucci A, Pieretti S, Davis P, Lai J, Rankin D, Porreca F, Hruby VJ. Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides. Journal of Medicinal Chemistry. 56: 3419-23. PMID 23547584 DOI: 10.1021/Jm301456C |
0.456 |
|
| 2013 |
Brabez N, Saunders K, Nguyen KL, Jayasundera TB, Weber C, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting. Acs Medicinal Chemistry Letters. 4: 98-102. PMID 23524643 DOI: 10.1021/Ml300312B |
0.802 |
|
| 2013 |
Brabez N, Nguyen KL, Saunders K, Lacy R, Xu L, Gillies RJ, Lynch RM, Chassaing G, Lavielle S, Hruby VJ. Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment. Bioorganic & Medicinal Chemistry Letters. 23: 2422-5. PMID 23489620 DOI: 10.1016/J.Bmcl.2013.02.022 |
0.768 |
|
| 2013 |
Hruby VJ, Cai M. Design of peptide and peptidomimetic ligands with novel pharmacological activity profiles. Annual Review of Pharmacology and Toxicology. 53: 557-80. PMID 23294313 DOI: 10.1146/Annurev-Pharmtox-010510-100456 |
0.688 |
|
| 2013 |
Cai M, Stankova M, Muthu D, Mayorov A, Yang Z, Trivedi D, Cabello C, Hruby VJ. An unusual conformation of γ-melanocyte-stimulating hormone analogues leads to a selective human melanocortin 1 receptor antagonist for targeting melanoma cells. Biochemistry. 52: 752-64. PMID 23276279 DOI: 10.1021/Bi300723F |
0.832 |
|
| 2013 |
Rinne P, Nordlund W, Heinonen I, Penttinen AM, Saraste A, Ruohonen ST, Mäkelä S, Vähätalo L, Kaipio K, Cai M, Hruby VJ, Ruohonen S, Savontaus E. α-Melanocyte-stimulating hormone regulates vascular NO availability and protects against endothelial dysfunction. Cardiovascular Research. 97: 360-8. PMID 23131503 DOI: 10.1093/Cvr/Cvs335 |
0.615 |
|
| 2012 |
Xu L, Josan JS, Vagner J, Caplan MR, Hruby VJ, Mash EA, Lynch RM, Morse DL, Gillies RJ. Heterobivalent ligands target cell-surface receptor combinations in vivo. Proceedings of the National Academy of Sciences of the United States of America. 109: 21295-300. PMID 23236171 DOI: 10.1073/Pnas.1211762109 |
0.754 |
|
| 2012 |
Mollica A, Pinnen F, Stefanucci A, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2. Journal of Medicinal Chemistry. 55: 8477-82. PMID 22966938 DOI: 10.1021/jm300947s |
0.314 |
|
| 2012 |
Tumati S, Largent-Milnes TM, Keresztes AI, Yamamoto T, Vanderah TW, Roeske WR, Hruby VJ, Varga EV. Tachykinin NKâ‚ receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation. European Journal of Pharmacology. 684: 64-70. PMID 22724132 DOI: 10.1016/J.Ejphar.2012.03.025 |
0.67 |
|
| 2012 |
Mollica A, Pinnen F, Stefanucci A, Feliciani F, Campestre C, Mannina L, Sobolev AP, Lucente G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues. Journal of Medicinal Chemistry. 55: 3027-35. PMID 22394120 DOI: 10.1021/Jm201402V |
0.462 |
|
| 2012 |
Liu Z, Mehta SJ, Lee KS, Grossman B, Qu H, Gu X, Nichol GS, Hruby VJ. Thio-Claisen rearrangement used in preparing anti-β-functionalized γ,δ-unsaturated amino acids: scope and limitations. The Journal of Organic Chemistry. 77: 1289-300. PMID 22283513 DOI: 10.1021/Jo201753Q |
0.716 |
|
| 2012 |
Liu Z, Mehta SJ, Hruby VJ. Strategies for asymmetric synthesis of amino acids withγ,δ -Unsaturation Organic Preparations and Procedures International. 44: 222-255. DOI: 10.1080/00304948.2012.676507 |
0.312 |
|
| 2012 |
Liu J, Ying J, Chow VTK, Hruby VJ, Satyanarayanajois SD. Correction to Structure–Activity Studies of Peptides from the “Hot-Spot” Region of Human CD2 Protein: Development of Peptides for Immunomodulation Journal of Medicinal Chemistry. 55: 7295-7295. DOI: 10.1021/Jm3010948 |
0.555 |
|
| 2011 |
Vardanyan RS, Danagulyan GG, Mkrtchyan AD, Hruby VJ. Recyclization reactions of 1-alkylpyrimidinium salts. Heterocyclic Communications. 17: 129-133. PMID 25400328 DOI: 10.1515/Hc.2011.025 |
0.618 |
|
| 2011 |
Hruby VJ, Cai M, Nyberg J, Muthu D. Approaches to the rational design of selective melanocortin receptor antagonists. Expert Opinion On Drug Discovery. 6: 543-57. PMID 22646078 DOI: 10.1517/17460441.2011.565743 |
0.826 |
|
| 2011 |
Barkey NM, Tafreshi NK, Josan JS, De Silva CR, Sill KN, Hruby VJ, Gillies RJ, Morse DL, Vagner J. Development of melanoma-targeted polymer micelles by conjugation of a melanocortin 1 receptor (MC1R) specific ligand. Journal of Medicinal Chemistry. 54: 8078-84. PMID 22011200 DOI: 10.1021/Jm201226W |
0.759 |
|
| 2011 |
Brabez N, Lynch RM, Xu L, Gillies RJ, Chassaing G, Lavielle S, Hruby VJ. Design, synthesis, and biological studies of efficient multivalent melanotropin ligands: tools toward melanoma diagnosis and treatment. Journal of Medicinal Chemistry. 54: 7375-84. PMID 21928837 DOI: 10.1021/Jm2009937 |
0.821 |
|
| 2011 |
Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands. Bioorganic & Medicinal Chemistry. 19: 6135-42. PMID 21925887 DOI: 10.1016/J.Bmc.2011.08.027 |
0.697 |
|
| 2011 |
Grieco P, Brancaccio D, Novellino E, Hruby VJ, Carotenuto A. Conformational study on cyclic melanocortin ligands and new insight into their binding mode at the MC4 receptor. European Journal of Medicinal Chemistry. 46: 3721-33. PMID 21652123 DOI: 10.1016/J.Ejmech.2011.05.038 |
0.425 |
|
| 2011 |
Josan JS, Handl HL, Sankaranarayanan R, Xu L, Lynch RM, Vagner J, Mash EA, Hruby VJ, Gillies RJ. Cell-specific targeting by heterobivalent ligands. Bioconjugate Chemistry. 22: 1270-8. PMID 21639139 DOI: 10.1021/Bc1004284 |
0.826 |
|
| 2011 |
Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain. Brain Research. 1395: 1-11. PMID 21550594 DOI: 10.1016/J.Brainres.2011.04.024 |
0.807 |
|
| 2011 |
Wu Z, Hruby VJ. Backbone alignment modeling of the structure-activity relationships of opioid ligands. Journal of Chemical Information and Modeling. 51: 1151-64. PMID 21488692 DOI: 10.1021/Ci2000852 |
0.416 |
|
| 2011 |
Mayorov AV, Cai M, Palmer ES, Tanaka DK, Cain JP, Dedek MM, Tan B, Trivedi D, Hruby VJ. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102. PMID 21486697 DOI: 10.1016/J.Bmcl.2011.03.019 |
0.833 |
|
| 2011 |
Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies. Journal of Medicinal Chemistry. 54: 2029-38. PMID 21366266 DOI: 10.1021/Jm101023R |
0.711 |
|
| 2011 |
Josan JS, De Silva CR, Yoo B, Lynch RM, Pagel MD, Vagner J, Hruby VJ. Fluorescent and lanthanide labeling for ligand screens, assays, and imaging. Methods in Molecular Biology (Clifton, N.J.). 716: 89-126. PMID 21318902 DOI: 10.1007/978-1-61779-012-6_6 |
0.73 |
|
| 2011 |
Cai M, Liu Z, Qu H, Fan H, Zheng Z, Hruby VJ. Utilize conjugated melanotropins for the earlier diagnosis and treatment of melanoma. European Journal of Pharmacology. 660: 188-93. PMID 21315067 DOI: 10.1016/J.Ejphar.2011.01.032 |
0.729 |
|
| 2011 |
Hruby VJ, Cai M, Cain J, Nyberg J, Trivedi D. Design of novel melanocortin receptor ligands: multiple receptors, complex pharmacology, the challenge. European Journal of Pharmacology. 660: 88-93. PMID 21208601 DOI: 10.1016/J.Ejphar.2010.10.109 |
0.831 |
|
| 2011 |
Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of potent μ and δ opioid agonists with high lipophilicity. Journal of Medicinal Chemistry. 54: 382-6. PMID 21128594 DOI: 10.1021/Jm100982D |
0.732 |
|
| 2011 |
Mollica A, Pinnen F, Feliciani F, Stefanucci A, Lucente G, Davis P, Porreca F, Ma SW, Lai J, Hruby VJ. New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers. Amino Acids. 40: 1503-11. PMID 20924622 DOI: 10.1007/S00726-010-0760-7 |
0.344 |
|
| 2011 |
Vardanyan R, Kumirov VK, Hruby VJ. Improved synthesis of d,l-fluorocitric acid Journal of Fluorine Chemistry. 132: 920-924. DOI: 10.1016/J.Jfluchem.2011.07.006 |
0.637 |
|
| 2010 |
Nichol GS, Vardanyan R, Hruby VJ. Synthesis and Crystallographic Study of N'-(1-benzylpiperidin-4-yl)acetohydrazide. Journal of Chemical Crystallography. 40: 961-964. PMID 25505832 DOI: 10.1007/S10870-010-9771-1 |
0.632 |
|
| 2010 |
Nichol GS, Kumirov VK, Vardanyan R, Hruby VJ. Proton sharing and transfer in some zwitterionic compounds based on 4-oxo-4-((1-phenethylpiperidin-4-yl)(phenyl)amino)alcanoic acids. Crystengcomm / Rsc. 12: 3651-3657. PMID 25425961 DOI: 10.1039/B923698H |
0.62 |
|
| 2010 |
Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance. British Journal of Pharmacology. 161: 986-1001. PMID 20977451 DOI: 10.1111/J.1476-5381.2010.00824.X |
0.669 |
|
| 2010 |
Giordano C, Sansone A, Masi A, Lucente G, Punzi P, Mollica A, Pinnen F, Feliciani F, Cacciatore I, Davis P, Lai J, Ma SW, Porreca F, Hruby V. Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. European Journal of Medicinal Chemistry. 45: 4594-600. PMID 20692738 DOI: 10.1016/J.Ejmech.2010.07.022 |
0.494 |
|
| 2010 |
Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905. PMID 20688117 DOI: 10.1016/J.Peptides.2010.06.026 |
0.832 |
|
| 2010 |
Yamamoto T, Nair P, Jacobsen NE, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing two penicillamines. Journal of Medicinal Chemistry. 53: 5491-501. PMID 20617791 DOI: 10.1021/Jm100157M |
0.767 |
|
| 2010 |
Lee YS, Fernandes S, Kulkarani V, Mayorov A, Davis P, Ma SW, Brown K, Gillies RJ, Lai J, Porreca F, Hruby VJ. Design and synthesis of trivalent ligands targeting opioid, cholecystokinin, and melanocortin receptors for the treatment of pain. Bioorganic & Medicinal Chemistry Letters. 20: 4080-4. PMID 20547453 DOI: 10.1016/J.Bmcl.2010.05.078 |
0.764 |
|
| 2010 |
Doedens L, Opperer F, Cai M, Beck JG, Dedek M, Palmer E, Hruby VJ, Kessler H. Multiple N-methylation of MT-II backbone amide bonds leads to melanocortin receptor subtype hMC1R selectivity: pharmacological and conformational studies. Journal of the American Chemical Society. 132: 8115-28. PMID 20496895 DOI: 10.1021/Ja101428M |
0.698 |
|
| 2010 |
Torino D, Mollica A, Pinnen F, Feliciani F, Lucente G, Fabrizi G, Portalone G, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin-2 analogues containing (Z)-alpha,beta-didehydrophenylalanine (Delta(Z)Phe) residues. Journal of Medicinal Chemistry. 53: 4550-4. PMID 20476738 DOI: 10.1021/Jm1001343 |
0.442 |
|
| 2010 |
Xu L, Vagner J, Alleti R, Rao V, Jagadish B, Morse DL, Hruby VJ, Gillies RJ, Mash EA. Synthesis and characterization of a Eu-DTPA-PEGO-MSH(4) derivative for evaluation of binding of multivalent molecules to melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 20: 2489-92. PMID 20304640 DOI: 10.1016/J.Bmcl.2010.03.007 |
0.416 |
|
| 2010 |
Juni A, Cai M, Stankova M, Waxman AR, Arout C, Klein G, Dahan A, Hruby VJ, Mogil JS, Kest B. Sex-specific mediation of opioid-induced hyperalgesia by the melanocortin-1 receptor. Anesthesiology. 112: 181-8. PMID 19996949 DOI: 10.1097/Aln.0B013E3181C53849 |
0.752 |
|
| 2010 |
De Silva CR, Vagner J, Lynch R, Gillies RJ, Hruby VJ. Optimization of time-resolved fluorescence assay for detection of europium-tetraazacyclododecyltetraacetic acid-labeled ligand-receptor interactions. Analytical Biochemistry. 398: 15-23. PMID 19852924 DOI: 10.1016/J.Ab.2009.10.031 |
0.425 |
|
| 2010 |
Hruby VJ, Alves I, Cowell S, Salamon Z, Tollin G. Use of plasmon waveguide resonance (PWR) spectroscopy for examining binding, signaling and lipid domain partitioning of membrane proteins. Life Sciences. 86: 569-74. PMID 19281827 DOI: 10.1016/J.Lfs.2009.02.027 |
0.749 |
|
| 2010 |
Liu Z, Qu H, Gu X, Lee KS, Grossman B, Kumirov VK, Hruby VJ. Novel anti-β-functionalized γ,δ-unsaturated amino acids via a thio-Claisen rearrangement Tetrahedron Letters. 51: 3518-3520. DOI: 10.1016/J.Tetlet.2010.04.102 |
0.697 |
|
| 2010 |
Liu Z, Qu H, Gu X, Lee K, Grossman B, Kumirov VK, Hruby VJ. ChemInform Abstract: Novel anti-β-Functionalized γ,δ-Unsaturated Amino Acids via a Thio-Claisen Rearrangement. Cheminform. 41: no-no. DOI: 10.1002/chin.201043191 |
0.539 |
|
| 2010 |
Xiong C, Wang W, Hruby VJ. ChemInform Abstract: A General Asymmetric Synthesis of syn- and anti-β-Substituted Cysteine and Serine Derivatives. Cheminform. 33: no-no. DOI: 10.1002/chin.200239190 |
0.48 |
|
| 2010 |
Wang W, Xiong C, Zhang J, Hruby VJ. ChemInform Abstract: Practical, Asymmetric Synthesis of Aromatic-Substituted Bulky and Hydrophobic Tryptophan and Phenylalanine Derivatives. Cheminform. 33: no-no. DOI: 10.1002/chin.200235176 |
0.631 |
|
| 2010 |
Wang W, Zhang J, Xiong C, Hruby VJ. ChemInform Abstract: Design and Synthesis of Hydrophobic, Bulky χ2-Constrained Phenylalanine and Naphthylalanine Derivatives. Cheminform. 33: no-no. DOI: 10.1002/chin.200227225 |
0.629 |
|
| 2010 |
Wang W, Xiong C, Yang J, Hruby VJ. ChemInform Abstract: An Efficient Synthesis of (2S,6S)- and meso-Diaminopimelic Acids via Asymmetric Hydrogenation. Cheminform. 33: no-no. DOI: 10.1002/chin.200217193 |
0.466 |
|
| 2010 |
Wang W, Xiong C, Yang J, Hruby VJ. ChemInform Abstract: Practical, Asymmetric Synthesis of Aromatic-Substituted Bulky and Hydrophobic Tryptophan Derivatives. Cheminform. 33: no-no. DOI: 10.1002/chin.200203193 |
0.502 |
|
| 2010 |
Han G, Lewis A, Hruby VJ. ChemInform Abstract: Synthesis of (2S,3S)-β-Methyltryptophan. Cheminform. 32: no-no. DOI: 10.1002/chin.200140197 |
0.445 |
|
| 2010 |
Tamaki M, Han G, Hruby VJ. ChemInform Abstract: Synthesis of 4-cis-Phenyl-L-proline via Hydrogenolysis. Cheminform. 32: no-no. DOI: 10.1002/chin.200138179 |
0.453 |
|
| 2010 |
Wang W, Xiong C, Hruby VJ. ChemInform Abstract: An Efficient Approach to Asymmetric Synthesis of Dipeptide β-Turn Mimetics: Indolizidinone Amino Acids. Cheminform. 32: no-no. DOI: 10.1002/chin.200130193 |
0.49 |
|
| 2010 |
Soloshonok VA, Cai C, Hruby VJ. ChemInform Abstract: (S)- or (R)-3-(E-Enoyl)-4-phenyl-1,3-oxazolidin-2-ones: Ideal Michael Acceptors to Afford a Virtually Complete Control of Simple and Face Diastereoselectivity in Addition Reactions with Glycine Derivatives. Cheminform. 31: no-no. DOI: 10.1002/chin.200027129 |
0.47 |
|
| 2010 |
Soloshonok VA, Cai C, Hruby VJ. ChemInform Abstract: Asymmetric Michael Addition Reactions of Chiral Ni(II)-Complex of Glycine with (N-trans-Enoyl)oxazolidines: Improved Reactivity and Stereochemical Outcome. Cheminform. 31: no-no. DOI: 10.1002/chin.200012189 |
0.471 |
|
| 2010 |
Hruby VJ, ET AL. EA. ChemInform Abstract: De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199913184 |
0.398 |
|
| 2010 |
HRUBY VJ, ET AL. EA. ChemInform Abstract: Modifications of the 4,4′-Residues and SAR Studies of Biphalin, a Highly Potent Opioid Receptor Active Peptide. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199824163 |
0.375 |
|
| 2010 |
HAN Y, LIAO S, QIU W, CAI C, HRUBY VJ. ChemInform Abstract: Total Asymmetric Synthesis of Highly Constrained Amino Acids β- Isopropyl-2′,6′-dimethyl-tyrosines. Cheminform. 28: no-no. DOI: 10.1002/chin.199743204 |
0.508 |
|
| 2010 |
HRUBY VJ. ChemInform Abstract: Design and Synthesis of Conformationally-Constrained, Opioid Receptor Selective Peptides: NMR and Theoretical Calculations of Peptide Conformation Cheminform. 22: no-no. DOI: 10.1002/chin.199121301 |
0.337 |
|
| 2009 |
Kumarasinghe IR, Hruby VJ, Nichol GS. 1-(4-Methoxy-phen-yl)-3-phenyl-1H-pyrazol-5-amine. Acta Crystallographica. Section E, Structure Reports Online. 65: o1170. PMID 21583972 DOI: 10.1107/S1600536809015463 |
0.777 |
|
| 2009 |
Yamamoto T, Nair P, Jacobsen NE, Vagner J, Kulkarni V, Davis P, Ma SW, Navratilova E, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Improving metabolic stability by glycosylation: bifunctional peptide derivatives that are opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 52: 5164-75. PMID 20560643 DOI: 10.1021/Jm900473P |
0.764 |
|
| 2009 |
Yamamoto T, Nair P, Ma SW, Davis P, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. The biological activity and metabolic stability of peptidic bifunctional compounds that are opioid receptor agonists and neurokinin-1 receptor antagonists with a cystine moiety. Bioorganic & Medicinal Chemistry. 17: 7337-43. PMID 19762245 DOI: 10.1016/J.Bmc.2009.08.035 |
0.477 |
|
| 2009 |
Yang Y, Hruby VJ, Chen M, Crasto C, Cai M, Harmon CM. Novel binding motif of ACTH analogues at the melanocortin receptors. Biochemistry. 48: 9775-84. PMID 19743876 DOI: 10.1021/Bi900634E |
0.709 |
|
| 2009 |
Cai M, Nyberg J, Hruby VJ. Melanotropins as drugs for the treatment of obesity and other feeding disorders: potential and problems. Current Topics in Medicinal Chemistry. 9: 554-63. PMID 19689365 DOI: 10.2174/156802609788897817 |
0.813 |
|
| 2009 |
Xu L, Vagner J, Josan J, Lynch RM, Morse DL, Baggett B, Han H, Mash EA, Hruby VJ, Gillies RJ. Enhanced targeting with heterobivalent ligands. Molecular Cancer Therapeutics. 8: 2356-65. PMID 19671749 DOI: 10.1158/1535-7163.Mct-08-1183 |
0.791 |
|
| 2009 |
Torino D, Mollica A, Pinnen F, Lucente G, Feliciani F, Davis P, Lai J, Ma SW, Porreca F, Hruby VJ. Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorganic & Medicinal Chemistry Letters. 19: 4115-8. PMID 19560919 DOI: 10.1016/J.Bmcl.2009.06.008 |
0.447 |
|
| 2009 |
Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorganic & Medicinal Chemistry. 17: 5044-53. PMID 19540763 DOI: 10.1016/J.Bmc.2009.05.065 |
0.828 |
|
| 2009 |
Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[1-(4-Sulfamoylphenyl)-5-p-tolyl-1H-pyrazol-3-yl]propanoic acid and 3-[5-(4-bromophenyl)-1-(4-sulfamoylphenyl)-1H-pyrazol-3-yl]propanoic acid-dichloromethane-diethyl ether-water (2/0.72/1/1). Acta Crystallographica. Section C, Crystal Structure Communications. 65: o296-9. PMID 19498242 DOI: 10.1107/S010827010901676X |
0.779 |
|
| 2009 |
Salamon Z, Tollin G, Alves I, Hruby V. Chapter 6. Plasmon resonance methods in membrane protein biology applications to GPCR signaling. Methods in Enzymology. 461: 123-46. PMID 19480917 DOI: 10.1016/S0076-6879(09)05406-8 |
0.7 |
|
| 2009 |
Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. Journal of Medicinal Chemistry. 52: 3627-35. PMID 19473029 DOI: 10.1021/Jm801300C |
0.835 |
|
| 2009 |
Josan JS, Morse DL, Xu L, Trissal M, Baggett B, Davis P, Vagner J, Gillies RJ, Hruby VJ. Solid-phase synthetic strategy and bioevaluation of a labeled delta-opioid receptor ligand Dmt-Tic-Lys for in vivo imaging. Organic Letters. 11: 2479-82. PMID 19445485 DOI: 10.1021/Ol900200K |
0.789 |
|
| 2009 |
Nair P, Yamamoto T, Kulkarni V, Moye S, Navratilova E, Davis P, Largent T, Ma SW, Yamamura HI, Vanderah T, Lai J, Porreca F, Hruby VJ. Novel bifunctional peptides as opioid agonists and NK-1 antagonists. Advances in Experimental Medicine and Biology. 611: 537-8. PMID 19400302 DOI: 10.1007/978-0-387-73657-0_235 |
0.764 |
|
| 2009 |
Lee Y, Petrov R, Kulkarni V, Min BJ, Ma SW, Davis P, Oyarzo J, Vanderah T, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of mu/delta opioid ligands: enkephalin analogues containing 4-anilidopiperidine moiety. Advances in Experimental Medicine and Biology. 611: 517-8. PMID 19400292 DOI: 10.1007/978-0-387-73657-0_225 |
0.815 |
|
| 2009 |
Fernandes SM, Sankaranarayanan R, Xu L, Josan J, Vagner J, Gillies R, Hruby VJ. Synthesis of bivalent MSH ligands and evaluation of their binding to hMC4R using MSH lanthaligand. Advances in Experimental Medicine and Biology. 611: 433-4. PMID 19400253 DOI: 10.1007/978-0-387-73657-0_186 |
0.799 |
|
| 2009 |
Josan JS, Sankaranarayanan R, Handl HL, Fernandes S, Xu L, Vagner J, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors--a step towards personal medicine. Advances in Experimental Medicine and Biology. 611: 413-4. PMID 19400245 DOI: 10.1007/978-0-387-73657-0_178 |
0.811 |
|
| 2009 |
Hruby VJ, Cai M, Dedek M, Qu H, Palmer E, Mayorov A, Trivedi D, Tsaprailis G, Yang Y. Peptide and non-peptide mimetics utilize different pathways for signal transduction. Advances in Experimental Medicine and Biology. 611: 305-7. PMID 19400204 DOI: 10.1007/978-0-387-73657-0_137 |
0.815 |
|
| 2009 |
Kessler H, Chatterjee J, Doedens L, Operrer F, Biron E, Hoyer D, Schmid H, Gilon C, Hruby VJ, Mierkes DF. New perspective in peptide chemistry by N-alkylation. Advances in Experimental Medicine and Biology. 611: 229-31. PMID 19400173 DOI: 10.1007/978-0-387-73657-0_106 |
0.325 |
|
| 2009 |
Kulkarni VV, Lee YS, Salibay C, Davis P, Ma SW, Porreca F, Hruby VJ. Novel analogues of bifunctional ligands for opioid and melanocortin 4 receptor. Advances in Experimental Medicine and Biology. 611: 195-6. PMID 19400157 DOI: 10.1007/978-0-387-73657-0_90 |
0.769 |
|
| 2009 |
Min BJ, Mayorov AV, Cai M, Palmer E, Hruby VJ. Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors. Advances in Experimental Medicine and Biology. 611: 187-8. PMID 19400153 DOI: 10.1007/978-0-387-73657-0_86 |
0.786 |
|
| 2009 |
Kumarasinghe IR, Hruby VJ, Nichol GS. 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-1H-pyrazol-3-yl]propionic acid and the corresponding methyl ester. Acta Crystallographica. Section C, Crystal Structure Communications. 65: o163-6. PMID 19346614 DOI: 10.1107/S010827010900941X |
0.782 |
|
| 2009 |
Yang Y, Cai M, Chen M, Qu H, McPherson D, Hruby V, Harmon CM. Key amino acid residues in the melanocortin-4 receptor for nonpeptide THIQ specific binding and signaling. Regulatory Peptides. 155: 46-54. PMID 19303903 DOI: 10.1016/J.Regpep.2009.03.006 |
0.758 |
|
| 2009 |
Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J. Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors. Brain : a Journal of Neurology. 132: 778-87. PMID 19050032 DOI: 10.1093/Brain/Awn330 |
0.74 |
|
| 2009 |
Chen M, Cai M, McPherson D, Hruby V, Harmon CM, Yang Y. Contribution of the transmembrane domain 6 of melanocortin-4 receptor to peptide [Pro5, DNal (2')8]-gamma-MSH selectivity. Biochemical Pharmacology. 77: 114-24. PMID 18930713 DOI: 10.1016/J.Bcp.2008.09.023 |
0.718 |
|
| 2009 |
VALLE G, KAZMIERSKI W, CRISMA M, BONORA G, TONIOLO C, HRUBY V. Constrained phenylalanine analogues International Journal of Peptide and Protein Research. 40: 222-232. DOI: 10.1111/J.1399-3011.1992.Tb00295.X |
0.339 |
|
| 2009 |
AL-OBEIDI F, SANDERSON DG, HRUBY VJ. Synthesis of β and γ-fluorenylmethyl esters of respectively Nα-Boc-L-aspartic acid and Nα-Boc-L-glutamic acid International Journal of Peptide and Protein Research. 35: 215-218. DOI: 10.1111/J.1399-3011.1990.Tb00940.X |
0.31 |
|
| 2009 |
WILKES BC, CODY WL, HRUBY VJ, CASTRUCCI AMDL, HADLEY ME. Comparative biological activities of potent analogues of α-melanotropin International Journal of Peptide and Protein Research. 27: 685-694. DOI: 10.1111/J.1399-3011.1986.Tb01066.X |
0.355 |
|
| 2009 |
WRIGH DE, AGARWAL NS, HRUBY VJ. SYNTHESIS OF PROTECTED SECRETIN16-27 ON A MERRIFIELD RESIN International Journal of Peptide and Protein Research. 15: 271-278. DOI: 10.1111/J.1399-3011.1980.Tb02577.X |
0.349 |
|
| 2009 |
YANG YC, HRUBY VJ, HEWARD CB, HADLEY ME. SYNTHESIS OF α- AND β-MELANOCYTE STIMULATING HORMONES* International Journal of Peptide and Protein Research. 15: 130-138. DOI: 10.1111/J.1399-3011.1980.Tb02559.X |
0.333 |
|
| 2009 |
Liu Z, Qu H, Gu X, Min BJ, Nyberg J, Hruby VJ. Enantioselective synthesis of anti-β-substituted γ,δ- unsaturated amino acids: A highly selective asymmetric Thio-Claisen rearrangement (Organic Letters (2008) 10) Organic Letters. 11: 497. DOI: 10.1021/Ol8027913 |
0.789 |
|
| 2009 |
Liu Z, Qu H, Gu X, Min BJ, Nyberg J, Hruby VJ. ChemInform Abstract: Enantioselective Synthesis of anti-β-Substituted γ,δ-Unsaturated Amino Acids: A Highly Selective Asymmetric Thio-Claisen Rearrangement. Cheminform. 40. DOI: 10.1002/chin.200904186 |
0.571 |
|
| 2008 |
Josan JS, Vagner J, Handl HL, Sankaranarayanan R, Gillies RJ, Hruby VJ. Solid-Phase Synthesis of Heterobivalent Ligands Targeted to Melanocortin and Cholecystokinin Receptors. International Journal of Peptide Research and Therapeutics. 14: 293-300. PMID 19714261 DOI: 10.1007/S10989-008-9150-3 |
0.826 |
|
| 2008 |
Min BJ, Gu X, Yamamoto T, Petrov RR, Qu H, Lee YS, Hruby VJ. Synthesis of a novel benzyl-octahydropyrazino[1,2-a]pyrimidin-6-one derivative as a convenient internal bicyclic peptidomimetic. Tetrahedron Letters. 49: 2316-2319. PMID 19340283 DOI: 10.1016/J.Tetlet.2008.01.137 |
0.797 |
|
| 2008 |
Yamamoto T, Nair P, Jacobsen NE, Davis P, Ma SW, Navratilova E, Moye S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 6334-47. PMID 18821747 DOI: 10.1021/Jm800389V |
0.487 |
|
| 2008 |
Liu Z, Qu H, Gu X, Min BJ, Nichol GS, Nyberg J, Hruby VJ. Enantioselective synthesis of anti-beta-substituted gamma,delta-unsaturated amino acids: a highly selective asymmetric thio-Claisen rearrangement. Organic Letters. 10: 4105-8. PMID 18702500 DOI: 10.1021/Ol801657Q |
0.794 |
|
| 2008 |
Agnes RS, Ying J, Kövér KE, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional cyclic disulfide peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Peptides. 29: 1413-23. PMID 18502541 DOI: 10.1016/J.Peptides.2008.03.022 |
0.838 |
|
| 2008 |
Vagner J, Qu H, Hruby VJ. Peptidomimetics, a synthetic tool of drug discovery. Current Opinion in Chemical Biology. 12: 292-6. PMID 18423417 DOI: 10.1016/J.Cbpa.2008.03.009 |
0.586 |
|
| 2008 |
Grieco P, Cai M, Liu L, Mayorov A, Chandler K, Trivedi D, Lin G, Campiglia P, Novellino E, Hruby VJ. Design and microwave-assisted synthesis of novel macrocyclic peptides active at melanocortin receptors: discovery of potent and selective hMC5R receptor antagonists. Journal of Medicinal Chemistry. 51: 2701-7. PMID 18412316 DOI: 10.1021/Jm701181N |
0.831 |
|
| 2008 |
Yamamoto T, Nair P, Vagner J, Largent-Milnes T, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Yamamura HI, Vanderah TW, Porreca F, Hruby VJ. A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists. Journal of Medicinal Chemistry. 51: 1369-76. PMID 18266313 DOI: 10.1021/Jm070332F |
0.735 |
|
| 2008 |
Vagner J, Xu L, Handl HL, Josan JS, Morse DL, Mash EA, Gillies RJ, Hruby VJ. Heterobivalent ligands crosslink multiple cell-surface receptors: the human melanocortin-4 and delta-opioid receptors. Angewandte Chemie (International Ed. in English). 47: 1685-8. PMID 18205159 DOI: 10.1002/Anie.200702770 |
0.781 |
|
| 2008 |
Georgieva T, Devanathan S, Stropova D, Park CK, Salamon Z, Tollin G, Hruby VJ, Roeske WR, Yamamura HI, Varga E. Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling. European Journal of Pharmacology. 581: 19-29. PMID 18162180 DOI: 10.1016/J.Ejphar.2007.11.053 |
0.427 |
|
| 2008 |
Lee M, Kim A, Conwell IM, Hruby V, Mayorov A, Cai M, Wardlaw SL. Effects of selective modulation of the central melanocortin-3-receptor on food intake and hypothalamic POMC expression. Peptides. 29: 440-7. PMID 18155809 DOI: 10.1016/J.Peptides.2007.11.005 |
0.765 |
|
| 2008 |
Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. Journal of Medicinal Chemistry. 51: 187-95. PMID 18088090 DOI: 10.1021/Jm070461W |
0.824 |
|
| 2008 |
Sutton GM, Josephine Babin M, Gu X, Hruby VJ, Butler AA. A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally. Peptides. 29: 104-11. PMID 18054119 DOI: 10.1016/J.Peptides.2007.10.014 |
0.63 |
|
| 2008 |
Lee YS, Agnes RS, Cain JP, Kulkarni V, Cai M, Salibay C, Ciano K, Petrov R, Mayorov A, Vagner J, Trivedi D, Davis P, Ma SW, Lai J, Porreca F, ... ... Hruby VJ, et al. Opioid and melanocortin receptors: do they have overlapping pharmacophores? Biopolymers. 90: 433-8. PMID 17657709 DOI: 10.1002/Bip.20814 |
0.836 |
|
| 2008 |
Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction Drug Addiction: From Basic Research to Therapy. 477-494. DOI: 10.1007/978-0-387-76678-2_28 |
0.383 |
|
| 2008 |
Qu H, Gu X, Liu Z, Min BJ, Hruby VJ. ChemInform Abstract: Asymmetric Eschenmoser-Claisen Rearrangement for anti-β-Substituted γ,δ-Unsaturated Amino Acids. Cheminform. 39. DOI: 10.1002/chin.200812203 |
0.546 |
|
| 2007 |
Lee YS, Petrov R, Park CK, Ma SW, Davis P, Lai J, Porreca F, Vardanyan R, Hruby VJ. Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. Journal of Medicinal Chemistry. 50: 5528-32. PMID 17927164 DOI: 10.1021/Jm061465O |
0.825 |
|
| 2007 |
Qu H, Gu X, Liu Z, Min BJ, Hruby VJ. Asymmetric Eschenmoser-Claisen rearrangement for anti-beta-substituted gamma,delta-unsaturated amino acids. Organic Letters. 9: 3997-4000. PMID 17760455 DOI: 10.1021/Ol701704H |
0.711 |
|
| 2007 |
Handl HL, Sankaranarayanan R, Josan JS, Vagner J, Mash EA, Gillies RJ, Hruby VJ. Synthesis and evaluation of bivalent NDP-alpha-MSH(7) peptide ligands for binding to the human melanocortin receptor 4 (hMC4R). Bioconjugate Chemistry. 18: 1101-9. PMID 17591746 DOI: 10.1021/Bc0603642 |
0.826 |
|
| 2007 |
King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry. 7: 1098-1106. PMID 17584130 DOI: 10.2174/156802607780906564 |
0.724 |
|
| 2007 |
Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry. 7: 1107-19. PMID 17584128 DOI: 10.2174/156802607780906645 |
0.803 |
|
| 2007 |
Chen M, Cai M, Aprahamian CJ, Georgeson KE, Hruby V, Harmon CM, Yang Y. Contribution of the conserved amino acids of the melanocortin-4 receptor in [corrected] [Nle4,D-Phe7]-alpha-melanocyte-stimulating [corrected] hormone binding and signaling. The Journal of Biological Chemistry. 282: 21712-9. PMID 17545153 DOI: 10.1074/Jbc.M702285200 |
0.663 |
|
| 2007 |
Mollica A, Guardiani G, Davis P, Ma SW, Porreca F, Lai J, Mannina L, Sobolev AP, Hruby VJ. Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. Journal of Medicinal Chemistry. 50: 3138-42. PMID 17539621 DOI: 10.1021/Jm061048B |
0.47 |
|
| 2007 |
Yamamoto T, Nair P, Davis P, Ma SW, Navratilova E, Moye S, Tumati S, Lai J, Vanderah TW, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists. Journal of Medicinal Chemistry. 50: 2779-86. PMID 17516639 DOI: 10.1021/Jm061369N |
0.51 |
|
| 2007 |
Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides. 28: 1191-6. PMID 17482720 DOI: 10.1016/J.Peptides.2007.02.012 |
0.794 |
|
| 2007 |
Jagadish B, Sankaranarayanan R, Xu L, Richards R, Vagner J, Hruby VJ, Gillies RJ, Mash EA. Squalene-derived flexible linkers for bioactive peptides. Bioorganic & Medicinal Chemistry Letters. 17: 3310-3. PMID 17448660 DOI: 10.1016/J.Bmcl.2007.04.001 |
0.669 |
|
| 2007 |
Zhou M, Nakatani E, Gronenberg LS, Tokimoto T, Wirth MJ, Hruby VJ, Roberts A, Lynch RM, Ghosh I. Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules. Bioconjugate Chemistry. 18: 323-32. PMID 17373766 DOI: 10.1021/Bc0601929 |
0.389 |
|
| 2007 |
Lee YS, Nyberg J, Moye S, Agnes RS, Davis P, Ma SW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Understanding the structural requirements of 4-anilidopiperidine analogues for biological activities at mu and delta opioid receptors. Bioorganic & Medicinal Chemistry Letters. 17: 2161-5. PMID 17329100 DOI: 10.1016/J.Bmcl.2007.01.114 |
0.836 |
|
| 2007 |
Navratilova E, Waite S, Stropova D, Eaton MC, Alves ID, Hruby VJ, Roeske WR, Yamamura HI, Varga EV. Quantitative evaluation of human delta opioid receptor desensitization using the operational model of drug action. Molecular Pharmacology. 71: 1416-26. PMID 17322005 DOI: 10.1124/Mol.106.030023 |
0.438 |
|
| 2007 |
Ballet S, Mayorov AV, Cai M, Tymecka D, Chandler KB, Palmer ES, Rompaey KV, Misicka A, Tourwé D, Hruby VJ. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. Bioorganic & Medicinal Chemistry Letters. 17: 2492-8. PMID 17314042 DOI: 10.1016/J.Bmcl.2007.02.020 |
0.802 |
|
| 2007 |
Bowen ME, Monguchi Y, Sankaranarayanan R, Vagner J, Begay LJ, Xu L, Jagadish B, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of a branched flexible linker for bioactive peptides. The Journal of Organic Chemistry. 72: 1675-80. PMID 17279799 DOI: 10.1021/Jo0704412 |
0.688 |
|
| 2007 |
Lee YS, Agnes RS, Davis P, Ma SW, Badghisi H, Lai J, Porreca F, Hruby VJ. Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. Journal of Medicinal Chemistry. 50: 165-8. PMID 17201419 DOI: 10.1021/Jm061268P |
0.805 |
|
| 2007 |
Shinoda K, Hruby VJ, Porreca F. Antihyperalgesic effects of loperamide in a model of rat neuropathic pain are mediated by peripheral delta-opioid receptors. Neuroscience Letters. 411: 143-6. PMID 17110034 DOI: 10.1016/J.Neulet.2006.10.027 |
0.438 |
|
| 2007 |
Josan JS, Vagner J, Xu L, Morse DL, Gillies RJ, Hruby VJ. CMR 2007: 4.02: A novel targeting approach to molecular imaging based on heteromultivalency Contrast Media & Molecular Imaging. 2: 283-283. DOI: 10.1002/Cmmi.174 |
0.702 |
|
| 2006 |
Qu H, Carducci MD, Nichol GS, Hruby VJ. (1R,2S)-Benzyl N-[3-(diisopropylaminocarbonyl)-2-phenylprop-3-enyl]carbamate. Acta Crystallographica. Section E, Structure Reports Online. 62: o3921-o3922. PMID 17710225 DOI: 10.1107/S1600536806032041 |
0.551 |
|
| 2006 |
Petrov RR, Vardanyan RS, Nichol GS, Carducci MD, Ma SW, Lai JY, Hruby VJ. 4-{N-[2-(1,3-Dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]anilino}-1-phenethylpiperidinium chloride methanol disolvate. Acta Crystallographica. Section E, Structure Reports Online. 62: o2815-o2816. PMID 17268579 DOI: 10.1107/S1600536806021817 |
0.751 |
|
| 2006 |
Carducci MD, Gu X, Cole JR, Hruby VJ. [N-({(R)-2-[(N-Benzylprolyl)amino]phenyl}-phenylmethylene)-2(S)-(pent-4-enyl)-glycinato]nickel(II). Acta Crystallographica. Section E, Structure Reports Online. 62: m1219-m1220. PMID 17268578 DOI: 10.1107/S160053680601244X |
0.583 |
|
| 2006 |
Ndungu JM, Cain JP, Davis P, Ma SW, Vanderah TW, Lai J, Porreca F, Hruby VJ. Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides. Tetrahedron Letters. 47: 2233-2236. PMID 17203138 DOI: 10.1016/J.Tetlet.2006.01.096 |
0.829 |
|
| 2006 |
Ying J, Gu X, Cai M, Dedek M, Vagner J, Trivedi DB, Hruby VJ. Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor. Journal of Medicinal Chemistry. 49: 6888-96. PMID 17154518 DOI: 10.1021/Jm060768F |
0.843 |
|
| 2006 |
Cai M, Varga EV, Stankova M, Mayorov A, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists. Chemical Biology & Drug Design. 68: 183-93. PMID 17105482 DOI: 10.1111/J.1747-0285.2006.00432.X |
0.812 |
|
| 2006 |
Vagner J, Handl HL, Monguchi Y, Jana U, Begay LJ, Mash EA, Hruby VJ, Gillies RJ. Rigid linkers for bioactive peptides. Bioconjugate Chemistry. 17: 1545-50. PMID 17105235 DOI: 10.1021/Bc060154P |
0.414 |
|
| 2006 |
Hruby VJ, Porreca F, Yamamura HI, Tollin G, Agnes RS, Lee YS, Cai M, Alves I, Cowell S, Varga E, Davis P, Salamon Z, Roeske W, Vanderah T, Lai J. New paradigms and tools in drug design for pain and addiction. The Aaps Journal. 8: E450-60. PMID 17025262 DOI: 10.1208/Aapsj080353 |
0.812 |
|
| 2006 |
Qu H, Gu X, Min BJ, Liu Z, Hruby VJ. Synthesis of Anti-beta-substituted gamma,delta-unsaturated amino acids via Eschenmoser-Claisen rearrangement. Organic Letters. 8: 4215-8. PMID 16956190 DOI: 10.1021/Ol061414L |
0.712 |
|
| 2006 |
Cain JP, Mayorov AV, Cai M, Wang H, Tan B, Chandler K, Lee Y, Petrov RR, Trivedi D, Hruby VJ. Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5462-7. PMID 16931008 DOI: 10.1016/J.Bmcl.2006.07.015 |
0.834 |
|
| 2006 |
Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorganic & Medicinal Chemistry Letters. 16: 4946-50. PMID 16828552 DOI: 10.1016/J.Bmcl.2006.06.040 |
0.818 |
|
| 2006 |
Mayorov AV, Han SY, Cai M, Hammer MR, Trivedi D, Hruby VJ. Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs. Chemical Biology & Drug Design. 67: 329-35. PMID 16784457 DOI: 10.1111/J.1747-0285.2006.00383.X |
0.817 |
|
| 2006 |
Agnes RS, Lee YS, Davis P, Ma SW, Badghisi H, Porreca F, Lai J, Hruby VJ. Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. Journal of Medicinal Chemistry. 49: 2868-75. PMID 16686530 DOI: 10.1021/Jm050921Q |
0.813 |
|
| 2006 |
Alves ID, Delaroche D, Mouillac B, Salamon Z, Tollin G, Hruby VJ, Lavielle S, Sagan S. The two NK-1 binding sites correspond to distinct, independent, and non-interconvertible receptor conformational states as confirmed by plasmon-waveguide resonance spectroscopy. Biochemistry. 45: 5309-18. PMID 16618119 DOI: 10.1021/Bi052586D |
0.376 |
|
| 2006 |
Mayorov AV, Cai M, Chandler KB, Petrov RR, Van Scoy AR, Yu Z, Tanaka DK, Trivedi D, Hruby VJ. Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. Journal of Medicinal Chemistry. 49: 1946-52. PMID 16539382 DOI: 10.1021/Jm0510326 |
0.842 |
|
| 2006 |
Lee YS, Agnes RS, Badghisi H, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. Journal of Medicinal Chemistry. 49: 1773-80. PMID 16509592 DOI: 10.1021/Jm050851N |
0.813 |
|
| 2006 |
Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ. Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position. Peptides. 27: 472-81. PMID 16303211 DOI: 10.1016/J.Peptides.2005.01.032 |
0.819 |
|
| 2006 |
Mollica A, Davis P, Ma SW, Porreca F, Lai J, Hruby VJ. Synthesis and biological activity of the first cyclic biphalin analogues. Bioorganic & Medicinal Chemistry Letters. 16: 367-72. PMID 16275086 DOI: 10.1016/J.Bmcl.2005.09.080 |
0.396 |
|
| 2006 |
Marks DL, Hruby V, Brookhart G, Cone RD. The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides. 27: 259-64. PMID 16274853 DOI: 10.1016/J.Peptides.2005.01.025 |
0.59 |
|
| 2006 |
Alves ID, Cowell SM, Salamon Z, Devanathan S, Tollin G, Hruby VJ. Erratum: Different structural states of the proteolipid membrane are produced by ligand binding to the human δ-opioid receptor as shown by plasmon-waveguide resonance spectroscopy (Molecular Pharmacology (2004) 65 (1248-1257)) Molecular Pharmacology. 69. DOI: 10.1124/Mol.69.1.406 |
0.406 |
|
| 2006 |
Alves ID, Salamon Z, Hruby VJ, Tollin G. Erratum: Ligand modulation of lateral segregation of a G-protein-coupled receptor into lipid microdomains in sphingomyelin/phosphatidylcholine solid-supported bilayers (Biochemistry (June 28, 2005) 44, 25 (9168-9178)) Biochemistry. 45. DOI: 10.1021/Bi068005H |
0.333 |
|
| 2006 |
Vardanyan RS, Hruby VJ. Synthesis of Essential Drugs Synthesis of Essential Drugs. |
0.564 |
|
| 2005 |
Vardanyan RS, Hruby VJ, Danagulyan GG, Mkrtchyan AD. Isomerization/Recyclization of some 5-Ethoxycarbonyl-pyrimidines. Journal of Heterocyclic Chemistry. 42: 557-562. PMID 16467919 DOI: 10.1002/Jhet.5570420413 |
0.622 |
|
| 2005 |
Vessey KA, Lencses KA, Rushforth DA, Hruby VJ, Stell WK. Glucagon receptor agonists and antagonists affect the growth of the chick eye: a role for glucagonergic regulation of emmetropization? Investigative Ophthalmology & Visual Science. 46: 3922-31. PMID 16249465 DOI: 10.1167/Iovs.04-1026 |
0.302 |
|
| 2005 |
Soloshonok VA, Cai C, Yamada T, Ueki H, Ohfune Y, Hruby VJ. Michael addition reactions between chiral equivalents of a nucleophilic glycine and (S)- or (R)-3-[(E)-enoyl]-4-phenyl-1,3-oxazolidin-2-ones as a general method for efficient preparation of beta-substituted pyroglutamic acids. Case of topographically controlled stereoselectivity. Journal of the American Chemical Society. 127: 15296-303. PMID 16248672 DOI: 10.1021/Ja0535561 |
0.559 |
|
| 2005 |
Liu J, Ying J, Chow VT, Hruby VJ, Satyanarayanajois SD. Structure-activity studies of peptides from the "hot-spot" region of human CD2 protein: development of peptides for immunomodulation. Journal of Medicinal Chemistry. 48: 6236-49. PMID 16190751 DOI: 10.1021/Jm0503547 |
0.543 |
|
| 2005 |
Fung S, Hruby VJ. Design of cyclic and other templates for potent and selective peptide alpha-MSH analogues. Current Opinion in Chemical Biology. 9: 352-8. PMID 16023401 DOI: 10.1016/J.Cbpa.2005.06.010 |
0.438 |
|
| 2005 |
Handl HL, Vagner J, Yamamura HI, Hruby VJ, Gillies RJ. Development of a lanthanide-based assay for detection of receptor-ligand interactions at the delta-opioid receptor. Analytical Biochemistry. 343: 299-307. PMID 16004955 DOI: 10.1016/J.Ab.2005.05.040 |
0.462 |
|
| 2005 |
Alves ID, Salamon Z, Hruby VJ, Tollin G. Ligand modulation of lateral segregation of a G-protein-coupled receptor into lipid microdomains in sphingomyelin/phosphatidylcholine solid-supported bilayers. Biochemistry. 44: 9168-78. PMID 15966741 DOI: 10.1021/Bi050207A |
0.398 |
|
| 2005 |
King T, Gardell LR, Wang R, Vardanyan A, Ossipov MH, Malan TP, Vanderah TW, Hunt SP, Hruby VJ, Lai J, Porreca F. Role of NK-1 neurotransmission in opioid-induced hyperalgesia. Pain. 116: 276-88. PMID 15964684 DOI: 10.1016/J.Pain.2005.04.014 |
0.381 |
|
| 2005 |
Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors. Peptides. 26: 1481-5. PMID 15876475 DOI: 10.1016/J.Peptides.2005.03.020 |
0.83 |
|
| 2005 |
Hsu R, Taylor JR, Newton SS, Alvaro JD, Haile C, Han G, Hruby VJ, Nestler EJ, Duman RS. Blockade of melanocortin transmission inhibits cocaine reward. The European Journal of Neuroscience. 21: 2233-42. PMID 15869520 DOI: 10.1111/J.1460-9568.2005.04038.X |
0.517 |
|
| 2005 |
Mollica A, Davis P, Ma SW, Lai J, Porreca F, Hruby VJ. Synthesis and biological evaluation of new biphalin analogues with non-hydrazine linkers. Bioorganic & Medicinal Chemistry Letters. 15: 2471-5. PMID 15863299 DOI: 10.1016/J.Bmcl.2005.03.067 |
0.452 |
|
| 2005 |
Devanathan S, Salamon Z, Nagar A, Narang S, Schleich D, Darman P, Hruby V, Tollin G. Subpicomolar sensing of delta-opioid receptor ligands by molecular-imprinted polymers using plasmon-waveguide resonance spectroscopy. Analytical Chemistry. 77: 2569-74. PMID 15828795 DOI: 10.1021/Ac048476E |
0.4 |
|
| 2005 |
Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/Ja0432158 |
0.688 |
|
| 2005 |
Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. Journal of Medicinal Chemistry. 48: 1839-48. PMID 15771429 DOI: 10.1021/Jm049579S |
0.815 |
|
| 2005 |
Lin J, Liao S, Hruby VJ. Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids. The Journal of Peptide Research : Official Journal of the American Peptide Society. 65: 105-12. PMID 15686541 DOI: 10.1111/J.1399-3011.2004.00194.X |
0.301 |
|
| 2005 |
Gu X, Ying J, Min B, Cain JP, Davis P, Willey P, Navratilova E, Yamamura HI, Porreca F, Hruby VJ. Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues. Biopolymers. 80: 151-63. PMID 15660379 DOI: 10.1002/Bip.20208 |
0.804 |
|
| 2005 |
Monguchi Y, Vagner J, Handl HL, Jana U, Begay LJ, Hruby VJ, Gillies RJ, Mash EA. Design, synthesis, and validation of rigid linkers for bioactive peptides Tetrahedron Letters. 46: 7589-7592. DOI: 10.1016/J.Tetlet.2005.08.151 |
0.446 |
|
| 2004 |
Handl HL, Vagner J, Han H, Mash E, Hruby VJ, Gillies RJ. Hitting multiple targets with multimeric ligands. Expert Opinion On Therapeutic Targets. 8: 565-86. PMID 15584863 DOI: 10.1517/14728222.8.6.565 |
0.382 |
|
| 2004 |
Cowell SM, Lee YS, Cain JP, Hruby VJ. Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands. Current Medicinal Chemistry. 11: 2785-98. PMID 15544476 DOI: 10.2174/0929867043364270 |
0.66 |
|
| 2004 |
Ossipov MH, Lai J, King T, Vanderah TW, Malan TP, Hruby VJ, Porreca F. Antinociceptive and nociceptive actions of opioids. Journal of Neurobiology. 61: 126-48. PMID 15362157 DOI: 10.1002/Neu.20091 |
0.32 |
|
| 2004 |
Gu X, Ying J, Agnes RS, Navratilova E, Davis P, Stahl G, Porreca F, Yamamura HI, Hruby VJ. Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues. Organic Letters. 6: 3285-8. PMID 15355033 DOI: 10.1021/Ol0488183 |
0.823 |
|
| 2004 |
Alves ID, Ciano KA, Boguslavski V, Varga E, Salamon Z, Yamamura HI, Hruby VJ, Tollin G. Selectivity, cooperativity, and reciprocity in the interactions between the delta-opioid receptor, its ligands, and G-proteins. The Journal of Biological Chemistry. 279: 44673-82. PMID 15317820 DOI: 10.1074/Jbc.M404713200 |
0.395 |
|
| 2004 |
Soloshonok VA, Ueki H, Tiwari R, Cai C, Hruby VJ. Virtually complete control of simple and face diastereoselectivity in the Michael addition reactions between achiral equivalents of a nucleophilic glycine and (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: practical method for preparation of beta-substituted pyroglutamic acids and prolines. The Journal of Organic Chemistry. 69: 4984-90. PMID 15255725 DOI: 10.1021/Jo0495438 |
0.581 |
|
| 2004 |
Handl HL, Vagner J, Yamamura HI, Hruby VJ, Gillies RJ. Lanthanide-based time-resolved fluorescence of in cyto ligand-receptor interactions. Analytical Biochemistry. 330: 242-50. PMID 15203329 DOI: 10.1016/J.Ab.2004.04.012 |
0.392 |
|
| 2004 |
Cai M, Stankova M, Pond SJ, Mayorov AV, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy. Journal of the American Chemical Society. 126: 7160-1. PMID 15186137 DOI: 10.1021/Ja049473M |
0.822 |
|
| 2004 |
Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/Jpet.104.069393 |
0.438 |
|
| 2004 |
Alves I, Cowell S, Lee YS, Tang X, Davis P, Porreca F, Hruby VJ. A novel 3-step enantioselective synthesis of pyrenylalanine with subsequent incorporation into opioid, CCK, and melanotropin ligands. Biochemical and Biophysical Research Communications. 318: 335-40. PMID 15120606 DOI: 10.1016/J.Bbrc.2004.04.033 |
0.777 |
|
| 2004 |
Alves ID, Cowell SM, Salamon Z, Devanathan S, Tollin G, Hruby VJ. Different structural states of the proteolipid membrane are produced by ligand binding to the human delta-opioid receptor as shown by plasmon-waveguide resonance spectroscopy. Molecular Pharmacology. 65: 1248-57. PMID 15102953 DOI: 10.1124/Mol.65.5.1248 |
0.436 |
|
| 2004 |
Cai M, Cai C, Mayorov AV, Xiong C, Cabello CM, Soloshonok VA, Swift JR, Trivedi D, Hruby VJ. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 116-31. PMID 15009533 DOI: 10.1111/J.1399-3011.2003.00105.X |
0.832 |
|
| 2004 |
Han G, Haskell-Luevano C, Kendall L, Bonner G, Hadley ME, Cone RD, Hruby VJ. De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach. Journal of Medicinal Chemistry. 47: 1514-26. PMID 14998337 DOI: 10.1021/Jm030452X |
0.772 |
|
| 2004 |
Vagner J, Handl HL, Gillies RJ, Hruby VJ. Novel targeting strategy based on multimeric ligands for drug delivery and molecular imaging: homooligomers of alpha-MSH. Bioorganic & Medicinal Chemistry Letters. 14: 211-5. PMID 14684330 DOI: 10.1016/J.Bmcl.2003.09.079 |
0.406 |
|
| 2004 |
Hruby V, Wang W, Xiong C, Yang J. An Efficient Synthesis of (2S,6S)- and meso-Diaminopimelic Acids via Asymmetric Hydrogenation Synthesis. 2002. DOI: 10.1055/S-2002-19295 |
0.576 |
|
| 2004 |
Cai C, Yamada T, Tiwari R, Hruby VJ, Soloshonok VA. Application of (S)- and (R)-methyl pyroglutamates as inexpensive, yet highly efficient chiral auxiliaries in the asymmetric Michael addition reactions Tetrahedron Letters. 45: 6855-6858. DOI: 10.1016/J.Tetlet.2004.07.096 |
0.566 |
|
| 2004 |
Ndungu JM, Gu X, Gross DE, Cain JP, Carducci MD, Hruby VJ. Synthesis of bicyclic dipeptide mimetics for the cholecystokinin and opioid receptors Tetrahedron Letters. 45: 4139-4142. DOI: 10.1016/J.Tetlet.2004.03.146 |
0.845 |
|
| 2004 |
Ndungu JM, Gu X, Gross DE, Ying J, Hruby VJ. A simple and efficient synthesis of an Asp-Gly dipeptide mimetic Tetrahedron Letters. 45: 3245-3247. DOI: 10.1016/J.Tetlet.2004.02.117 |
0.793 |
|
| 2004 |
Gu X, Ndungu JM, Qiu W, Ying J, Carducci MD, Wooden H, Hruby VJ. Large scale enantiomeric synthesis, purification, and characterization of ω-unsaturated amino acids via a Gly-Ni(II)-BPB-complex Tetrahedron. 60: 8233-8243. DOI: 10.1016/J.Tet.2004.06.087 |
0.794 |
|
| 2003 |
Ying J, Kövér KE, Gu X, Han G, Trivedi DB, Kavarana MJ, Hruby VJ. Solution structures of cyclic melanocortin agonists and antagonists by NMR. Biopolymers. 71: 696-716. PMID 14991679 DOI: 10.1002/Bip.10596 |
0.794 |
|
| 2003 |
Cowell SM, Gu X, Vagner J, Hruby VJ. Intelligent design in combinatorial chemistry: use of designed peptide libraries to explore secondary and tertiary structures in peptides and proteins. Methods in Enzymology. 369: 288-97. PMID 14722960 DOI: 10.1016/S0076-6879(03)69016-6 |
0.637 |
|
| 2003 |
Tollin G, Salamon Z, Hruby VJ. Techniques: plasmon-waveguide resonance (PWR) spectroscopy as a tool to study ligand-GPCR interactions. Trends in Pharmacological Sciences. 24: 655-9. PMID 14654307 DOI: 10.1016/J.Tips.2003.10.010 |
0.338 |
|
| 2003 |
Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of gamma-MSH analogues at the human melanocortin MC3, MC4, and MC5 receptors. Discovery of highly selective hMC3R, hMC4R, and hMC5R analogues. Journal of Medicinal Chemistry. 46: 4965-73. PMID 14584947 DOI: 10.1021/Jm030119T |
0.717 |
|
| 2003 |
Tollin G, Salamon Z, Cowell S, Hruby VJ. Plasmon-waveguide resonance spectroscopy: a new tool for investigating signal transduction by G-protein coupled receptors. Life Sciences. 73: 3307-11. PMID 14572873 DOI: 10.1016/J.Lfs.2003.07.001 |
0.424 |
|
| 2003 |
Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. The Journal of Peptide Research : Official Journal of the American Peptide Society. 62: 199-206. PMID 14531843 DOI: 10.1034/J.1399-3011.2003.00087.X |
0.661 |
|
| 2003 |
Alves ID, Salamon Z, Varga E, Yamamura HI, Tollin G, Hruby VJ. Direct observation of G-protein binding to the human delta-opioid receptor using plasmon-waveguide resonance spectroscopy. The Journal of Biological Chemistry. 278: 48890-7. PMID 14522991 DOI: 10.1074/Jbc.M306866200 |
0.413 |
|
| 2003 |
Zhang J, Xiong C, Ying J, Wang W, Hruby VJ. Stereoselective synthesis of novel dipeptide beta-turn mimetics targeting melanocortin peptide receptors. Organic Letters. 5: 3115-8. PMID 12916995 DOI: 10.1021/Ol0351347 |
0.766 |
|
| 2003 |
Balse-Srinivasan P, Grieco P, Cai M, Trivedi D, Hruby VJ. Structure-activity relationships of novel cyclic alpha-MSH/beta-MSH hybrid analogues that lead to potent and selective ligands for the human MC3R and human MC5R. Journal of Medicinal Chemistry. 46: 3728-33. PMID 12904077 DOI: 10.1021/Jm030111J |
0.708 |
|
| 2003 |
Xiong C, Zhang J, Davis P, Wang W, Ying J, Porreca F, Hruby VJ. Stereoselective synthesis of individual isomers of Leu-enkephalin analogues containing substituted beta-turn bicyclic dipeptide mimetics. Chemical Communications (Cambridge, England). 1598-9. PMID 12868772 DOI: 10.1039/B302235H |
0.765 |
|
| 2003 |
Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. MT-II induces penile erection via brain and spinal mechanisms. Annals of the New York Academy of Sciences. 994: 90-5. PMID 12851302 DOI: 10.1111/J.1749-6632.2003.Tb03166.X |
0.538 |
|
| 2003 |
Hruby VJ, Cai M, Grieco P, Han G, Kavarana M, Trivedi D. Exploring the stereostructural requirements of peptide ligands for the melanocortin receptors. Annals of the New York Academy of Sciences. 994: 12-20. PMID 12851293 DOI: 10.1111/J.1749-6632.2003.Tb03157.X |
0.784 |
|
| 2003 |
Hruby VJ, Agnes RS, Davis P, Ma SW, Lee YS, Vanderah TW, Lai J, Porreca F. Design of novel peptide ligands which have opioid agonist activity and CCK antagonist activity for the treatment of pain. Life Sciences. 73: 699-704. PMID 12801591 DOI: 10.1016/S0024-3205(03)00390-4 |
0.802 |
|
| 2003 |
Boguslavsky V, Hruby VJ, O'Brien DF, Misicka A, Lipkowski AW. Effect of peptide conformation on membrane permeability. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 287-97. PMID 12753376 DOI: 10.1034/J.1399-3011.2003.00047.X |
0.342 |
|
| 2003 |
Wessells H, Hruby VJ, Hackett J, Han G, Balse-Srinivasan P, Vanderah TW. Ac-Nle-c[Asp-His-DPhe-Arg-Trp-Lys]-NH2 induces penile erection via brain and spinal melanocortin receptors. Neuroscience. 118: 755-62. PMID 12710982 DOI: 10.1016/S0306-4522(02)00866-7 |
0.543 |
|
| 2003 |
Mogil JS, Wilson SG, Chesler EJ, Rankin AL, Nemmani KV, Lariviere WR, Groce MK, Wallace MR, Kaplan L, Staud R, Ness TJ, Glover TL, Stankova M, Mayorov A, Hruby VJ, et al. The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 100: 4867-72. PMID 12663858 DOI: 10.1073/Pnas.0730053100 |
0.774 |
|
| 2003 |
Varga EV, Rubenzik MK, Stropova D, Sugiyama M, Grife V, Hruby VJ, Rice KC, Roeske WR, Yamamura HI. Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment. The Journal of Pharmacology and Experimental Therapeutics. 306: 109-15. PMID 12660310 DOI: 10.1124/Jpet.103.049643 |
0.367 |
|
| 2003 |
Ying J, Ahn JM, Jacobsen NE, Brown MF, Hruby VJ. NMR solution structure of the glucagon antagonist [desHis1, desPhe6, Glu9]glucagon amide in the presence of perdeuterated dodecylphosphocholine micelles. Biochemistry. 42: 2825-35. PMID 12627948 DOI: 10.1021/Bi026629R |
0.693 |
|
| 2003 |
Han G, Quillan JM, Carlson K, Sadée W, Hruby VJ. Design of novel chimeric melanotropin-deltorphin analogues. Discovery of the first potent human melanocortin 1 receptor antagonist. Journal of Medicinal Chemistry. 46: 810-9. PMID 12593660 DOI: 10.1021/Jm020355O |
0.667 |
|
| 2003 |
Hosohata K, Varga EV, Alfaro-Lopez J, Tang X, Vanderah TW, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R) beta-methyl-2',6'-dimethyltyrosine-L-tetrahydroisoquinoline-3-carboxylic acid [(2S,3R)TMT-L-Tic-OH] is a potent, selective delta-opioid receptor antagonist in mouse brain. The Journal of Pharmacology and Experimental Therapeutics. 304: 683-8. PMID 12538822 DOI: 10.1124/Jpet.102.042929 |
0.354 |
|
| 2003 |
Okura T, Varga EV, Hosohata Y, Navratilova E, Cowell SM, Rice K, Nagase H, Hruby VJ, Roeske WR, Yamamura HI. Agonist-specific down-regulation of the human delta-opioid receptor. European Journal of Pharmacology. 459: 9-16. PMID 12505529 DOI: 10.1016/S0014-2999(02)02823-6 |
0.46 |
|
| 2003 |
Gu X, Cowell S, Ying J, Tang X, Hruby VJ. Synthesis of β-phenyl-δ,ε-unsaturated amino acids and stereoselective introduction of side chain groups into [4,3,0]-bicyclic β-turn dipeptides Tetrahedron Letters. 44: 5863-5866. DOI: 10.1016/S0040-4039(03)01383-2 |
0.699 |
|
| 2003 |
Zhang J, Wang W, Xiong C, Hruby VJ. Efficient and Stereoselective Synthesis of Novel cis-4-Substituted Proline Analogues. Cheminform. 34. DOI: 10.1016/S0040-4039(02)02865-4 |
0.678 |
|
| 2003 |
Zhang J, Wang W, Xiong C, Hruby VJ. Efficient and stereoselective synthesis of novel cis-4-substituted proline analogues Tetrahedron Letters. 44: 1413-1415. DOI: 10.1016/S0040-4039(02)02865-4 |
0.617 |
|
| 2003 |
Wang W, Cai M, Xiong C, Zhang J, Trivedi D, Hruby VJ. Design and Synthesis of Novel χ2-Constrained Phenylalanine, Naphthylalanine, and Tryptophan Analogues and Their Use in Biologically Active Melanotropin Peptides. Cheminform. 34. DOI: 10.1016/S0040-4020(02)00588-4 |
0.781 |
|
| 2003 |
Xiong C, Wang W, Hruby VJ. The General Asymmetric Synthesis of syn- and anti-β-Substituted Cysteine and Serine Derivatives Cheminform. 34. DOI: 10.1002/chin.200319236 |
0.48 |
|
| 2003 |
Soloshonok VA, Ueki H, Jiang C, Cai C, Hruby VJ. A Convenient, Room-Temperature — Organic Base Protocol for Preparing Chiral 3-(Enoyl)-1,3-oxazolidin-2-ones. Cheminform. 34. DOI: 10.1002/1522-2675(200211)85:11<3616::Aid-Hlca3616>3.0.Co;2-O |
0.546 |
|
| 2003 |
Hruby VJ, Chavez CGd, Kavarana M. Peptide and Protein Hormones, Peptide Neurotransmitters, and Therapeutic Agents Burger's Medicinal Chemistry and Drug Discovery. 35-73. DOI: 10.1002/0471266949.Bmc058 |
0.459 |
|
| 2002 |
Salamon Z, Hruby VJ, Tollin G, Cowell S. Binding of agonists, antagonists and inverse agonists to the human delta-opioid receptor produces distinctly different conformational states distinguishable by plasmon-waveguide resonance spectroscopy. The Journal of Peptide Research : Official Journal of the American Peptide Society. 60: 322-8. PMID 12464110 DOI: 10.1034/J.1399-3011.2002.21060.X |
0.417 |
|
| 2002 |
Grieco P, Lavecchia A, Cai M, Trivedi D, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors. Journal of Medicinal Chemistry. 45: 5287-94. PMID 12431055 DOI: 10.1021/Jm0202526 |
0.729 |
|
| 2002 |
Zhang J, Xiong C, Wang W, Ying J, Hruby VJ. Stereoselective bromination-suzuki cross-coupling of dehydroamino acids to form novel reverse-turn peptidomimetics: substituted unsaturated and saturated indolizidinone amino acids. Organic Letters. 4: 4029-32. PMID 12423078 DOI: 10.1021/Ol020160A |
0.733 |
|
| 2002 |
Hruby VJ. Designing peptide receptor agonists and antagonists. Nature Reviews. Drug Discovery. 1: 847-58. PMID 12415245 DOI: 10.1038/Nrd939 |
0.418 |
|
| 2002 |
Wang W, Yang J, Ying J, Xiong C, Zhang J, Cai C, Hruby VJ. Stereoselective synthesis of dipeptide beta-turn mimetics: 7-benzyl and 8-phenyl substituted azabicyclo[4.3.0]nonane amino acid esters. The Journal of Organic Chemistry. 67: 6353-60. PMID 12201753 DOI: 10.1021/Jo0203591 |
0.791 |
|
| 2002 |
Kavarana MJ, Trivedi D, Cai M, Ying J, Hammer M, Cabello C, Grieco P, Han G, Hruby VJ. Novel cyclic templates of alpha-MSH give highly selective and potent antagonists/agonists for human melanocortin-3/4 receptors. Journal of Medicinal Chemistry. 45: 2644-50. PMID 12036373 DOI: 10.1021/Jm020021Z |
0.83 |
|
| 2002 |
Xiong C, Wang W, Hruby VJ. A general asymmetric synthesis of syn- and anti-beta-substituted cysteine and serine derivatives. The Journal of Organic Chemistry. 67: 3514-7. PMID 12003570 DOI: 10.1021/Jo011172X |
0.566 |
|
| 2002 |
Flippen-Anderson JL, Deschamps JR, George C, Hruby VJ, Misicka A, Lipkowski AW. Crystal structure of biphalin sulfate: a multireceptor opioid peptide. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 123-33. PMID 11985706 DOI: 10.1034/J.1399-3011.2002.01967.X |
0.446 |
|
| 2002 |
Grieco P, Balse-Srinivasan P, Han G, Weinberg D, MacNeil T, Van der Ploeg LH, Hruby VJ. Synthesis and biological evaluation on hMC3, hMC4 and hMC5 receptors of gamma-MSH analogs substituted with L-alanine. The Journal of Peptide Research : Official Journal of the American Peptide Society. 59: 203-10. PMID 11966977 DOI: 10.1034/J.1399-3011.2002.01966.X |
0.659 |
|
| 2002 |
Grieco P, Han G, Weinberg D, Van der Ploeg LH, Hruby VJ. Design and synthesis of highly potent and selective melanotropin analogues of SHU9119 modified at position 6. Biochemical and Biophysical Research Communications. 292: 1075-80. PMID 11944925 DOI: 10.1006/Bbrc.2002.6739 |
0.669 |
|
| 2002 |
Moens K, Berger V, Ahn JM, Van Schravendijk C, Hruby VJ, Pipeleers D, Schuit F. Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells. Diabetes. 51: 669-75. PMID 11872665 DOI: 10.2337/Diabetes.51.3.669 |
0.544 |
|
| 2002 |
Lipkowski AW, Misicka A, Kosson D, Kosson P, Lachwa-From M, Brodzik-Bienkowska A, Hruby VJ. Biological properties of a new fluorescent biphalin fragment analogue. Life Sciences. 70: 893-7. PMID 11853227 DOI: 10.1016/S0024-3205(01)01467-9 |
0.425 |
|
| 2002 |
Xiong C, Wang W, Cai C, Hruby VJ. Regioselective and stereoselective nucleophilic ring opening reactions of a phenyl-substituted aziridine: enantioselective synthesis of beta-substituted tryptophan, cysteine, and serine derivatives. The Journal of Organic Chemistry. 67: 1399-402. PMID 11846696 DOI: 10.1021/Jo010860D |
0.691 |
|
| 2002 |
Hruby VJ, Qui W, Okayama T, Soloshonok VA. Design of nonpeptides from peptide ligands for peptide receptors. Methods in Enzymology. 343: 91-123. PMID 11665597 DOI: 10.1016/S0076-6879(02)43129-1 |
0.464 |
|
| 2002 |
Hruby VJ, Agnes RS, Cai C. Design of peptide agonists. Methods in Enzymology. 343: 73-91. PMID 11665596 DOI: 10.1016/S0076-6879(02)43128-X |
0.819 |
|
| 2002 |
Cowell SM, Balse-Srinivasan PM, Ahn JM, Hruby VJ. Design and synthesis of peptide antagonists and inverse agonists for G protein-coupled receptors. Methods in Enzymology. 343: 49-72. PMID 11665587 DOI: 10.1016/S0076-6879(02)43127-8 |
0.59 |
|
| 2002 |
Paizs B, Suhai S, Hargittai B, Hruby VJ, Somogyi A. Ab initio and MS/MS studies on protonated peptides containing basic and acidic amino acid residues - I. Solvated proton vs. salt-bridged structures and the cleavage of the terminal amide bond of protonated RD-NH2 International Journal of Mass Spectrometry. 219: 203-232. DOI: 10.1016/S1387-3806(02)00560-2 |
0.323 |
|
| 2002 |
Gu X, Tang X, Cowell S, Ying J, Hruby VJ. A novel strategy toward [6,5]-bicyclic β-turn dipeptide Tetrahedron Letters. 43: 6669-6672. DOI: 10.1016/S0040-4039(02)01338-2 |
0.7 |
|
| 2002 |
Wang W, Zhang J, Xiong C, Hruby VJ. Design and synthesis of hydrophobic, bulky χ2-constrained phenylalanine and naphthylalanine derivatives Tetrahedron Letters. 43: 2137-2140. DOI: 10.1016/S0040-4039(02)00249-6 |
0.687 |
|
| 2002 |
Wang W, Cai M, Xiong C, Zhang J, Trivedi D, Hruby VJ. Design and synthesis of novel χ2-constrained phenylalanine, naphthylalanine, and tryptophan analogues and their use in biologically active melanotropin peptides Tetrahedron. 58: 7365-7374. DOI: 10.1016/S0040-4020(02)00588-4 |
0.771 |
|
| 2002 |
Wang W, Xiong C, Zhang J, Hruby VJ. Practical, asymmetric synthesis of aromatic-substituted bulky and hydrophobic tryptophan and phenylalanine derivatives Tetrahedron. 58: 3101-3110. DOI: 10.1016/S0040-4020(02)00162-X |
0.715 |
|
| 2002 |
Soloshonok V, Ueki H, Jiang C, Cai C, Hruby V. A Convenient, Room-Temperature–Organic Base Protocol for Preparing Chiral 3-(Enoyl)-1,3-oxazolidin-2-ones Helvetica Chimica Acta. 85: 3616-3623. DOI: 10.1002/1522-2675(200211)85:11<3616::AID-HLCA3616>3.0.CO;2-O |
0.475 |
|
| 2001 |
Han G, Tamaki M, Hruby VJ. Fast, efficient and selective deprotection of the tert-butoxycarbonyl (Boc) group using HCl/dioxane (4 m). The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 338-41. PMID 11606219 DOI: 10.1034/J.1399-3011.2001.00935.X |
0.564 |
|
| 2001 |
Ahn JM, Gitu PM, Medeiros M, Swift JR, Trivedi D, Hruby VJ. A new approach to search for the bioactive conformation of glucagon: positional cyclization scanning. Journal of Medicinal Chemistry. 44: 3109-16. PMID 11543679 DOI: 10.1021/Jm010091Q |
0.622 |
|
| 2001 |
Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Development of potent glucagon antagonists: structure-activity relationship study of glycine at position 4. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 151-8. PMID 11532074 DOI: 10.1034/J.1399-3011.2001.00880.X |
0.659 |
|
| 2001 |
Tamaki M, Han G, Hruby VJ. Practical and efficient synthesis of orthogonally protected constrained 4-guanidinoprolines. The Journal of Organic Chemistry. 66: 1038-42. PMID 11430070 DOI: 10.1021/Jo005626M |
0.505 |
|
| 2001 |
Hosohata Y, Varga EV, Stropova D, Li X, Knapp RJ, Hruby VJ, Rice KC, Nagase H, Roeske WR, Yamamura HI. Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sciences. 68: 2233-42. PMID 11358332 DOI: 10.1016/S0024-3205(01)01011-6 |
0.409 |
|
| 2001 |
Hruby VJ. Design in topographical space of peptide and peptidomimetic ligands that affect behavior. A chemist's glimpse at the mind--body problem. Accounts of Chemical Research. 34: 389-97. PMID 11352717 DOI: 10.1021/Ar990063Q |
0.387 |
|
| 2001 |
Tamaki M, Han G, Hruby VJ. Synthesis of 4-cis-phenyl-L-proline via hydrogenolysis. The Journal of Organic Chemistry. 66: 3593-6. PMID 11348150 DOI: 10.1021/Jo005625U |
0.509 |
|
| 2001 |
Cai C, Soloshonok VA, Hruby VJ. Michael addition reactions between chiral Ni(II) complex of glycine and 3-(trans-enoyl)oxazolidin-2-ones. A case of electron donor-acceptor attractive interaction-controlled face diastereoselectivity. The Journal of Organic Chemistry. 66: 1339-50. PMID 11312965 DOI: 10.1021/Jo0014865 |
0.556 |
|
| 2001 |
Ahn JM, Medeiros M, Trivedi D, Hruby VJ. Development of potent truncated glucagon antagonists. Journal of Medicinal Chemistry. 44: 1372-9. PMID 11311060 DOI: 10.1021/Jm000453E |
0.625 |
|
| 2001 |
Grieco P, Gitu PM, Hruby VJ. Preparation of 'side-chain-to-side-chain' cyclic peptides by Allyl and Alloc strategy: potential for library synthesis. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 250-6. PMID 11298927 DOI: 10.1111/J.1399-3011.2001.00816.X |
0.363 |
|
| 2001 |
Mitchell SA, Pratt MR, Hruby VJ, Polt R. Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin Journal of Organic Chemistry. 66: 2327-2342. PMID 11281773 DOI: 10.1021/Jo005712M |
0.386 |
|
| 2001 |
Lipkowski AW, Misicka A, Hosohata K, Davis P, Yamamura HI, Porreca F, Hruby VJ. Biological properties of Phe(o)-opioid peptide analogues. Life Sciences. 68: 969-72. PMID 11213367 DOI: 10.1016/S0024-3205(00)00993-0 |
0.447 |
|
| 2001 |
Wang W, Xiong C, Yang J, Hruby VJ. Practical, asymmetric synthesis of aromatic-substituted bulky and hydrophobic tryptophan derivatives Tetrahedron Letters. 42: 7717-7719. DOI: 10.1016/S0040-4039(01)01626-4 |
0.598 |
|
| 2001 |
Han G, Hruby VJ. A study of conjugate addition to a γ,δ-dioxolanyl-α,β-unsaturated ester Tetrahedron Letters. 42: 4281-4283. DOI: 10.1016/S0040-4039(01)00719-5 |
0.523 |
|
| 2001 |
Han G, Lewis A, Hruby VJ. Synthesis of (2S,3S)-β-methyltryptophan Tetrahedron Letters. 42: 4601-4603. DOI: 10.1016/S0040-4039(01)00718-3 |
0.534 |
|
| 2001 |
Wang W, Xiong C, Hruby VJ. An efficient approach to asymmetric synthesis of dipeptide β-turn mimetics: Indolizidinone amino acids Tetrahedron Letters. 42: 3159-3161. DOI: 10.1016/S0040-4039(01)00409-9 |
0.573 |
|
| 2001 |
Qiu W, Gu X, Soloshonok VA, Carducci MD, Hruby VJ. Stereoselective synthesis of conformationally constrained reverse turn dipeptide mimetics Tetrahedron Letters. 42: 145-148. DOI: 10.1016/S0040-4039(00)01864-5 |
0.67 |
|
| 2001 |
Soloshonok VA, Tang X, Hruby VJ. Large-scale asymmetric synthesis of novel sterically constrained 2′,6′-dimethyl- and α,2′,6′-trimethyltyrosine and -phenylalanine derivatives via alkylation of chiral equivalents of nucleophilic glycine and alanine Tetrahedron. 57: 6375-6382. DOI: 10.1016/S0040-4020(01)00504-X |
0.305 |
|
| 2001 |
Hruby VJ, Soloshonok VA. Asymmetric synthesis of novel sterically constrained amino acids Tetrahedron. 57. DOI: 10.1016/S0040-4020(01)00498-7 |
0.322 |
|
| 2001 |
Han G, Hruby VJ. ChemInform Abstract: A Study of Conjugate Addition to a γ,δ-Dioxolanyl-α,β-unsaturated Ester. Cheminform. 32: no-no. DOI: 10.1002/chin.200139124 |
0.449 |
|
| 2001 |
Qiu W, Gu X, Soloshonok VA, Carducci MD, Hruby VJ. ChemInform Abstract: Stereoselective Synthesis of Conformationally Constrained Reverse Turn Dipeptide Mimetics Cheminform. 32: no-no. DOI: 10.1002/chin.200116194 |
0.552 |
|
| 2000 |
Grieco P, Balse PM, Weinberg D, MacNeil T, Hruby VJ. D-Amino acid scan of gamma-melanocyte-stimulating hormone: importance of Trp(8) on human MC3 receptor selectivity. Journal of Medicinal Chemistry. 43: 4998-5002. PMID 11150170 DOI: 10.1021/Jm000211E |
0.459 |
|
| 2000 |
Salamon Z, Cowell S, Varga E, Yamamura HI, Hruby VJ, Tollin G. Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions. Biophysical Journal. 79: 2463-74. PMID 11053123 DOI: 10.1016/S0006-3495(00)76489-7 |
0.431 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L, Yamazaki T. Rational design of highly diastereoselective, organic base-catalyzed, room-temperature Michael addition reactions. The Journal of Organic Chemistry. 65: 6688-96. PMID 11052120 DOI: 10.1021/Jo0008791 |
0.575 |
|
| 2000 |
Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Research. 881: 37-46. PMID 11033091 DOI: 10.1016/S0006-8993(00)02794-3 |
0.422 |
|
| 2000 |
Balse PM, Kim HJ, Han G, Hruby VJ. Evaluation of new base-labile 2-(4-nitrophenylsulfonyl) ethoxycarbonyl (Nsc)-amino acids for solid-phase peptide synthesis. The Journal of Peptide Research : Official Journal of the American Peptide Society. 56: 70-9. PMID 10961541 DOI: 10.1034/J.1399-3011.2000.00759.X |
0.597 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ. A Practical Asymmetric Synthesis of Enantiomerically Pure 3-Substituted Pyroglutamic Acids and Related Compounds This work was supported by grants from the U.S. Public Health Service (Grant DK 17420) and the National Institute of Drug Abuse (DA 06284 and DA 04248). The views expressed are those of the authors and not necessarily those of the USPHS. Angewandte Chemie (International Ed. in English). 39: 2172-2175. PMID 10941052 DOI: 10.1002/1521-3773(20000616)39:12<2172::Aid-Anie2172>3.0.Co;2-0 |
0.533 |
|
| 2000 |
Ko MC, Willmont KJ, Burritt A, Hruby VJ, Woods JH. Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys. European Journal of Pharmacology. 402: 69-76. PMID 10940359 DOI: 10.1016/S0014-2999(00)00503-3 |
0.418 |
|
| 2000 |
Hruby VJ, Balse PM. Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Current Medicinal Chemistry. 7: 945-70. PMID 10911024 DOI: 10.2174/0929867003374499 |
0.468 |
|
| 2000 |
Okayama T, Burritt A, Hruby VJ. 4-Alkoxy-2-hydroxybenzaldehyde (AHB): a versatile aldehyde linker for solid-phase synthesis of C-terminal modified peptides and peptidomimetics. Organic Letters. 2: 1787-90. PMID 10891158 DOI: 10.1021/Ol000048H |
0.323 |
|
| 2000 |
Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/Jm000077Y |
0.367 |
|
| 2000 |
Witt KA, Slate CA, Egleton RD, Huber JD, Yamamura HI, Hruby VJ, Davis TP. Assessment of stereoselectivity of trimethylphenylalanine analogues of delta-opioid [D-Pen(2),D-Pen(5)]-enkephalin. Journal of Neurochemistry. 75: 424-35. PMID 10854288 DOI: 10.1046/J.1471-4159.2000.0750424.X |
0.366 |
|
| 2000 |
Trivedi D, Lin Y, Ahn JM, Siegel M, Mollova NN, Schram KH, Hruby VJ. Design and synthesis of conformationally constrained glucagon analogues. Journal of Medicinal Chemistry. 43: 1714-22. PMID 10794689 DOI: 10.1021/Jm990559D |
0.646 |
|
| 2000 |
Shenderovich MD, Liao S, Qian X, Hruby VJ. A three-dimensional model of the delta-opioid pharmacophore: comparative molecular modeling of peptide and nonpeptide ligands. Biopolymers. 53: 565-80. PMID 10766952 DOI: 10.1002/(Sici)1097-0282(200006)53:7<565::Aid-Bip4>3.0.Co;2-5 |
0.485 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ. (S)- or (R)-3-(E-enoyl)-4-phenyl-1,3-oxazolidin-2-ones: ideal Michael acceptors to afford a virtually complete control of simple and face diastereoselectivity in addition reactions with glycine derivatives. Organic Letters. 2: 747-50. PMID 10754676 DOI: 10.1021/Ol990402F |
0.53 |
|
| 2000 |
Bilsky EJ, Qian X, Hruby VJ, Porreca F. Antinociceptive activity of [beta-methyl-2', 6'-dimethyltyrosine(1)]-substituted cyclic [D-Pen(2), D-Pen(5)]Enkephalin and [D-Ala(2),Asp(4)]Deltorphin analogs. The Journal of Pharmacology and Experimental Therapeutics. 293: 151-8. PMID 10734164 |
0.34 |
|
| 2000 |
Haskell-Luevano C, Lim S, Yuan W, Cone RD, Hruby VJ. Structure activity studies of the melanocortin antagonist SHU9119 modified at the 6, 7, 8, and 9 positions. Peptides. 21: 49-57. PMID 10704719 DOI: 10.1016/S0196-9781(99)00167-9 |
0.762 |
|
| 2000 |
Bonner GG, Davis P, Stropova D, Edsall S, Yamamura HI, Porreca F, Hruby VJ. Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biological activity assays. Journal of Medicinal Chemistry. 43: 569-80. PMID 10691683 DOI: 10.1021/Jm9900218 |
0.416 |
|
| 2000 |
Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3 |
0.411 |
|
| 2000 |
Okura T, Cowell SM, Varga E, Burkey TH, Roeske WR, Hruby VJ, Yamamura HI. Differential down-regulation of the human delta-opioid receptor by SNC80 and [D-Pen(2),D-Pen(5)]enkephalin. European Journal of Pharmacology. 387: R11-3. PMID 10650167 DOI: 10.1016/S0014-2999(99)00761-X |
0.441 |
|
| 2000 |
Hohmann JG, Teal TH, Clifton DK, Davis J, Hruby VJ, Han G, Steiner RA. Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R50-9. PMID 10644621 DOI: 10.1152/Ajpregu.2000.278.1.R50 |
0.531 |
|
| 2000 |
Kriss CT, Lou BS, Szabò LZ, Mitchell SA, Hruby VJ, Polt R. Enkephalin-based drug design: Conformational analysis of O-linked glycopeptides by NMR and molecular modeling Tetrahedron Asymmetry. 11: 9-25. DOI: 10.1016/S0957-4166(99)00544-3 |
0.392 |
|
| 2000 |
Tang X, Soloshonok VA, Hruby VJ. Convenient, asymmetric synthesis of enantiomerically pure 2′,6′-dimethyltyrosine (DMT) via alkylation of chiral equivalent of nucleophilic glycine Tetrahedron: Asymmetry. 11: 2917-2925. DOI: 10.1016/S0957-4166(00)00250-0 |
0.33 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ. Toward design of a practical methodology for stereocontrolled synthesis of χ-constrained pyroglutamic acids and related compounds. Virtually complete control of simple diastereoselectivity in the Michael addition reactions of glycine Ni(II) complexes with N-(enoyl)oxazolidinones Tetrahedron Letters. 41: 135-139. DOI: 10.1016/S0040-4039(99)02018-3 |
0.564 |
|
| 2000 |
Soloshonok* VA, Cai C, Hruby VJ. A unique case of face diastereoselectivity in the Michael addition reactions between Ni(II)-complexes of glycine and chiral 3-(E-enoyl)-1,3-oxazolidin-2-ones Tetrahedron Letters. 41: 9645-9649. DOI: 10.1016/S0040-4039(00)01737-8 |
0.527 |
|
| 2000 |
Qiu W, Soloshonok VA, Cai C, Tang X, Hruby VJ. Convenient, Large-Scale Asymmetric Synthesis of Enantiomerically Pure trans-Cinnamylglycine and -α-Alanine Tetrahedron. 56: 2577-2582. DOI: 10.1016/S0040-4020(00)00176-9 |
0.624 |
|
| 2000 |
Soloshonok VA, Cai C, Hruby VJ. ChemInform Abstract: A Practical Asymmetric Synthesis of Enantiomerically Pure 3-Substituted Pyroglutamic Acids and Related Compounds. Cheminform. 31: no-no. DOI: 10.1002/chin.200040108 |
0.515 |
|
| 1999 |
Liao S, Hruby VJ. An Asymmetric Synthesis Protocol to Prepare Topographically Constrained β-Substituted Aromatic Amino Acids Methods in Molecular Medicine. 23: 175-187. PMID 21380898 DOI: 10.1385/0-89603-517-4:175 |
0.43 |
|
| 1999 |
Hruby VJ, Agnes RS. Conformation-activity relationships of opioid peptides with selective activities at opioid receptors. Biopolymers. 51: 391-410. PMID 10797229 DOI: 10.1002/(Sici)1097-0282(1999)51:6<391::Aid-Bip3>3.0.Co;2-X |
0.803 |
|
| 1999 |
Alfaro-Lopez J, Okayama T, Hosohata K, Davis P, Porreca F, Yamamura HI, Hruby VJ. Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. Journal of Medicinal Chemistry. 42: 5359-68. PMID 10639279 DOI: 10.1021/Jm990337F |
0.449 |
|
| 1999 |
Gentry CL, Egleton RD, Gillespie T, Abbruscato TJ, Bechowski HB, Hruby VJ, Davis TP. The effect of halogenation on blood-brain barrier permeability of a novel peptide drug. Peptides. 20: 1229-38. PMID 10573295 DOI: 10.1016/S0196-9781(99)00127-8 |
0.371 |
|
| 1999 |
Kovelowski CJ, Ossipov MH, Hruby VJ, Porreca F. Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat. Pain. 83: 115-22. PMID 10534582 DOI: 10.1016/S0304-3959(99)00083-4 |
0.362 |
|
| 1999 |
Kovelowski CJ, Bian D, Hruby VJ, Lai J, Ossipov MH, Porreca F. Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat. Brain Research. 843: 12-7. PMID 10528105 DOI: 10.1016/S0006-8993(99)01803-X |
0.407 |
|
| 1999 |
Hosohata K, Burkey TH, Alfaro-Lopez J, Hruby VJ, Roeske WR, Yamamura HI. (2S,3R)TMT-L-Tic-OH is a potent inverse agonist at the human delta-opioid receptor. European Journal of Pharmacology. 380: R9-10. PMID 10513562 DOI: 10.1016/S0014-2999(99)00516-6 |
0.397 |
|
| 1999 |
Lipkowski AW, Misicka A, Davis P, Stropova D, Janders J, Lachwa M, Porreca F, Yamamura HI, Hruby VJ. Biological activity of fragments and analogues of the potent dimeric opioid peptide, biphalin. Bioorganic & Medicinal Chemistry Letters. 9: 2763-6. PMID 10509931 DOI: 10.1016/S0960-894X(99)00464-3 |
0.467 |
|
| 1999 |
Prabhu NV, Perkyns JS, Pettitt BM, Hruby VJ. Structure and dynamics of alpha-MSH using DRISM integral equation theory and stochastic dynamics. Biopolymers. 50: 255-72. PMID 10397788 DOI: 10.1002/(Sici)1097-0282(199909)50:3<255::Aid-Bip3>3.0.Co;2-V |
0.329 |
|
| 1999 |
Bartosz-Bechowski H, Davis P, Slaninova J, Malatynska E, Stropova D, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs that are hybrids of DPDPE-related peptides and metenkephalin-Arg-Gly-Leu: prohormone analogs that retain good potency and selectivity for delta opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 53: 329-36. PMID 10231722 DOI: 10.1034/J.1399-3011.1999.00033.X |
0.479 |
|
| 1999 |
Hruby VJ. Synthesis and use of large peptide libraries - An overview Collection of Czechoslovak Chemical Communications. 1: 34-46. DOI: 10.1135/Css199901034 |
0.334 |
|
| 1999 |
Soloshonok VA, Cai C, Hruby VJ. Asymmetric Michael addition reactions of chiral Ni(II)-complex of glycine with (N-trans-enoyl)oxazolidines: Improved reactivity and stereochemical outcome Tetrahedron Asymmetry. 10: 4265-4269. DOI: 10.1016/S0957-4166(99)00483-8 |
0.566 |
|
| 1999 |
Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L, Mischenko N. Stereochemically defined C-substituted glutamic acids and their derivatives. 1. An efficient asymmetric synthesis of (2S,3S)-3-methyl- and -3-trifluoromethylpyroglutamic acids Tetrahedron. 55: 12031-12044. DOI: 10.1016/S0040-4020(99)00711-5 |
0.567 |
|
| 1999 |
Soloshonok VA, Cai C, Hruby VJ, Van Meervelt L. Asymmetric synthesis of novel highly sterically constrained (2S,3S)-3-methyl-3-trifluoromethyl- and (2S,3S,4R)-3-trifluoromethyl-4-methylpyroglutamic acids Tetrahedron. 55: 12045-12058. DOI: 10.1016/S0040-4020(99)00710-3 |
0.553 |
|
| 1998 |
Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 274: R931-R938. PMID 29586884 DOI: 10.1152/ajpregu.1998.274.4.R931 |
0.556 |
|
| 1998 |
Vanderah TW, Raffa RB, Lashbrook J, Burritt A, Hruby V, Porreca F. Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats. European Journal of Pain (London, England). 2: 267-78. PMID 15102387 DOI: 10.1016/S1090-3801(98)90023-4 |
0.371 |
|
| 1998 |
Li G, Haq W, Xiang L, Lou BS, Hughes R, De Leon IA, Davis P, Gillespie TJ, Romanowski M, Zhu X, Misicka A, Lipkowski AW, Porreca F, Davis TP, Yamamura HI, ... ... Hruby VJ, et al. Modifications of the 4,4'-residues and SAR studies of Biphalin, a highly potent opioid receptor active peptide. Bioorganic & Medicinal Chemistry Letters. 8: 555-60. PMID 9871617 DOI: 10.1016/S0960-894X(98)00065-1 |
0.491 |
|
| 1998 |
Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI, Hruby VJ. De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor. Journal of Medicinal Chemistry. 41: 4767-76. PMID 9822547 DOI: 10.1021/Jm980374R |
0.52 |
|
| 1998 |
al-Obeidi F, Hruby VJ, Sawyer TK. Peptide and peptidomimetic libraries. Molecular diversity and drug design. Molecular Biotechnology. 9: 205-23. PMID 9718581 DOI: 10.1007/Bf02915794 |
0.358 |
|
| 1998 |
Nikiforovich GV, Sharma SD, Hadley ME, Hruby VJ. Studies of conformational isomerism in alpha-melanocyte stimulating hormone by design of cyclic analogues. Biopolymers. 46: 155-67. PMID 9699465 DOI: 10.1002/(Sici)1097-0282(199809)46:3<155::Aid-Bip3>3.0.Co;2-K |
0.346 |
|
| 1998 |
Sturm NS, Lin Y, Burley SK, Krstenansky JL, Ahn JM, Azizeh BY, Trivedi D, Hruby VJ. Structure-function studies on positions 17, 18, and 21 replacement analogues of glucagon: the importance of charged residues and salt bridges in glucagon biological activity. Journal of Medicinal Chemistry. 41: 2693-700. PMID 9667960 DOI: 10.1021/Jm980084A |
0.621 |
|
| 1998 |
Al-Obeidi F, O'Connor SD, Job C, Hruby VJ, Pettitt BM. NMR and quenched molecular dynamics studies of superpotent linear and cyclic alpha-melanotropins. The Journal of Peptide Research : Official Journal of the American Peptide Society. 51: 420-31. PMID 9650716 DOI: 10.1111/J.1399-3011.1998.Tb00640.X |
0.323 |
|
| 1998 |
Alfaro-Lopez J, Yuan W, Phan BC, Kamath J, Lou Q, Lam KS, Hruby VJ. Discovery of a novel series of potent and selective substrate-based inhibitors of p60c-src protein tyrosine kinase: conformational and topographical constraints in peptide design. Journal of Medicinal Chemistry. 41: 2252-60. PMID 9632358 DOI: 10.1021/Jm9707885 |
0.376 |
|
| 1998 |
Hosohata K, Burkey TH, Alfaro-Lopez J, Varga E, Hruby VJ, Roeske WR, Yamamura HI. Endomorphin-1 and endomorphin-2 are partial agonists at the human mu-opioid receptor. European Journal of Pharmacology. 346: 111-4. PMID 9617760 DOI: 10.1016/S0014-2999(98)00117-4 |
0.481 |
|
| 1998 |
Burkey TH, Ehlert FJ, Hosohata Y, Quock RM, Cowell S, Hosohata K, Varga E, Stropova D, Li X, Slate C, Nagase H, Porreca F, Hruby VJ, Roeske WR, Yamamura HI. The efficacy of delta-opioid receptor-selective drugs. Life Sciences. 62: 1531-6. PMID 9585131 DOI: 10.1016/S0024-3205(98)00102-7 |
0.366 |
|
| 1998 |
Ni XP, Kesterson RA, Sharma SD, Hruby VJ, Cone RD, Wiedemann E, Humphreys MH. Prevention of reflex natriuresis after acute unilateral nephrectomy by melanocortin receptor antagonists. The American Journal of Physiology. 274: R931-8. PMID 9575953 DOI: 10.1152/Ajpregu.1998.274.4.R931 |
0.616 |
|
| 1998 |
Slaninova J, Appleyard SM, Misicka A, Lipkowski AW, Knapp RJ, Weber SJ, Davis TP, Yamamura HI, Hruby VJ. [125I-Tyr1]biphalin binding to opioid receptors of rat brain and NG108-15 cell membranes. Life Sciences. 62: PL199-204. PMID 9570343 DOI: 10.1016/S0024-3205(98)00058-7 |
0.42 |
|
| 1998 |
Hruby VJ, Han G, Hadley ME. Letters in Peptide Science. 5: 117-120. DOI: 10.1023/A:1008808525647 |
0.473 |
|
| 1998 |
Liao S, Shenderovich MD, Zhang Z, Maletinska L, Slaninova J, Hruby VJ. Substitution of the Side-Chain-Constrained Amino Acids β-Methyl-2‘,6‘-Dimethyl-4‘-Methoxytyrosine in Position 2 of a Bicyclic Oxytocin Analogue Provides Unique Insights into the Bioactive Topography of Oxytocin Antagonists Journal of the American Chemical Society. 120: 7393-7394. DOI: 10.1021/Ja980848B |
0.339 |
|
| 1998 |
Hruby VJ. Chapter 16 Glucagon: Molecular biology and structure-activity Principles of Medical Biology. 10: 387-401. DOI: 10.1016/S1569-2582(97)80161-4 |
0.315 |
|
| 1998 |
Lin J, Liao S, Hruby VJ. Asymmetric syntheses of highly hydrophobic chimeric aromatic amino acids: 2-Amino-3,3'-diarylpropionic acids Tetrahedron Letters. 39: 3117-3120. DOI: 10.1016/S0040-4039(98)00516-4 |
0.318 |
|
| 1998 |
Olczak J, Kaczmarek K, Maszczyńska I, Lisowski M, Stropova D, Hruby VJ, Yamamura HI, Lipkowski AW, Zabrocki J. Consequences of cis-amide bond simulation in opioid peptides International Journal of Peptide Research and Therapeutics. 5: 437-440. DOI: 10.1007/Bf02443502 |
0.438 |
|
| 1998 |
Hruby VJ, Han G, Hadley ME. Design and bioactivities of melanotropic peptide agonists and antagonists: Design based on a conformationally constrained somatostatin template Letters in Peptide Science. 5: 117-120. DOI: 10.1007/Bf02443451 |
0.671 |
|
| 1997 |
Hruby VJ, Ahn JM, Liao S. Synthesis of oligopeptide and peptidomimetic libraries. Current Opinion in Chemical Biology. 1: 114-9. PMID 9667835 DOI: 10.1016/S1367-5931(97)80117-2 |
0.561 |
|
| 1997 |
Hruby VJ, Bartosz-Bechowski H, Davis P, Slaninova J, Zalewska T, Stropova D, Porreca F, Yamamura HI. Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 40: 3957-62. PMID 9397176 DOI: 10.1021/Jm9704762 |
0.428 |
|
| 1997 |
Romanowski M, Zhu X, Ramaswami V, Misicka A, Lipkowski AW, Hruby VJ, O'Brien DF. Interaction of a highly potent dimeric enkephalin analog, biphalin, with model membranes Biochimica Et Biophysica Acta - Biomembranes. 1329: 245-258. PMID 9371416 DOI: 10.1016/S0005-2736(97)00115-6 |
0.332 |
|
| 1997 |
Schiöth HB, Muceniece R, Mutulis F, Prusis P, Lindeberg G, Sharma SD, Hruby VJ, Wikberg JES. Selectivity of cyclic [D-Nal7] and [D-Phe7] substituted MSH analogues for the melanocortin receptor subtypes Peptides. 18: 1009-1013. PMID 9357059 DOI: 10.1016/S0196-9781(97)00079-X |
0.443 |
|
| 1997 |
Haaseth RC, Zalewska T, Davis P, Yamamura HI, Porreca F, Hruby VJ. Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 171-7. PMID 9309580 DOI: 10.1111/J.1399-3011.1997.Tb01182.X |
0.478 |
|
| 1997 |
Abbruscato TJ, Thomas SA, Hruby VJ, Davis TP. Brain and spinal cord distribution of biphalin: correlation with opioid receptor density and mechanism of CNS entry. Journal of Neurochemistry. 69: 1236-45. PMID 9282948 DOI: 10.1046/J.1471-4159.1997.69031236.X |
0.366 |
|
| 1997 |
Hruby VJ, Li G, Haskell-Luevano C, Shenderovich M. Design of peptides, proteins, and peptidomimetics in chi space. Biopolymers. 43: 219-66. PMID 9277134 DOI: 10.1002/(Sici)1097-0282(1997)43:3<219::Aid-Bip3>3.0.Co;2-Y |
0.64 |
|
| 1997 |
Haskell-Luevano C, Toth K, Boteju L, Job C, Castrucci AM, Hadley ME, Hruby VJ. beta-Methylation of the Phe7 and Trp9 melanotropin side chain pharmacophores affects ligand-receptor interactions and prolonged biological activity. Journal of Medicinal Chemistry. 40: 2740-9. PMID 9276019 DOI: 10.1021/Jm970018T |
0.609 |
|
| 1997 |
Misicka A, Cavagnero S, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors. The Journal of Peptide Research : Official Journal of the American Peptide Society. 50: 48-54. PMID 9273887 DOI: 10.1111/J.1399-3011.1997.Tb00619.X |
0.479 |
|
| 1997 |
Azizeh BY, Ahn JM, Caspari R, Shenderovich MD, Trivedi D, Hruby VJ. The role of phenylalanine at position 6 in glucagon's mechanism of biological action: multiple replacement analogues of glucagon. Journal of Medicinal Chemistry. 40: 2555-62. PMID 9258362 DOI: 10.1021/Jm960800D |
0.6 |
|
| 1997 |
Hruby VJ, Shenderovich M, Lam KS, Lebl M. Design considerations and computer modeling related to the development of molecular scaffolds and peptide mimetics for combinatorial chemistry. Molecular Diversity. 2: 46-56. PMID 9238633 DOI: 10.1007/Bf01718700 |
0.333 |
|
| 1997 |
Kramer TH, Bartosz-Bechowski H, Davis P, Hruby VJ, Porreca F. Extraordinary potency of a novel delta opioid receptor agonist is due in part to increased efficacy. Life Sciences. 61: 129-35. PMID 9217271 DOI: 10.1016/S0024-3205(97)00367-6 |
0.489 |
|
| 1997 |
Haskell-Luevano C, Hendrata S, North C, Sawyer TK, Hadley ME, Hruby VJ, Dickinson C, Gantz I. Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. Journal of Medicinal Chemistry. 40: 2133-9. PMID 9216831 DOI: 10.1021/Jm960840H |
0.688 |
|
| 1997 |
Azizeh BY, Van Tine BA, Trivedi D, Hruby VJ. Pure glucagon antagonists: biological activities and cAMP accumulation using phosphodiesterase inhibitors. Peptides. 18: 633-41. PMID 9213355 DOI: 10.1016/S0196-9781(97)00131-9 |
0.399 |
|
| 1997 |
Quock RM, Hosohata Y, Knapp RJ, Burkey TH, Hosohata K, Zhang X, Rice KC, Nagase H, Hruby VJ, Porreca F, Roeske WR, Yamamura HI. Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. European Journal of Pharmacology. 326: 101-4. PMID 9178661 DOI: 10.1016/S0014-2999(97)83488-7 |
0.436 |
|
| 1997 |
Patel D, McKinley BD, Davis TP, Porreca F, Yamamura HI, Hruby VJ. Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: design, synthesis, and bioactivity. Bioconjugate Chemistry. 8: 434-41. PMID 9177851 DOI: 10.1021/Bc970027G |
0.352 |
|
| 1997 |
Sturm NS, Hutzler AM, David CS, Azizeh BY, Trivedi D, Hruby VJ. Structure-activity studies of hydrophobic amino acid replacements at positions 9, 11 and 16 of glucagon. The Journal of Peptide Research : Official Journal of the American Peptide Society. 49: 293-9. PMID 9176812 DOI: 10.1111/J.1399-3011.1997.Tb01129.X |
0.413 |
|
| 1997 |
Haskell-Luevano C, Nikiforovich G, Sharma SD, Yang YK, Dickinson C, Hruby VJ, Gantz I. Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors. Journal of Medicinal Chemistry. 40: 1738-48. PMID 9171884 DOI: 10.1021/Jm960845E |
0.685 |
|
| 1997 |
Bonner GG, Davis P, Stropova D, Ferguson R, Yamamura HI, Porreca F, Hruby VJ. Opioid peptides: simultaneous delta agonism and mu antagonism in somatostatin analogues. Peptides. 18: 93-100. PMID 9114458 DOI: 10.1016/S0196-9781(96)00242-2 |
0.508 |
|
| 1997 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4. Life Sciences. 60: 1263-9. PMID 9096243 DOI: 10.1016/S0024-3205(97)00069-6 |
0.506 |
|
| 1997 |
Huang QH, Entwistle ML, Alvaro JD, Duman RS, Hruby VJ, Tatro JB. Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3343-51. PMID 9096167 DOI: 10.1523/Jneurosci.17-09-03343.1997 |
0.313 |
|
| 1997 |
Schiöth HB, Muceniece R, Szardenings M, Prusis P, Lindeberg G, Sharma SD, Hruby VJ, Wikberg JES. Characterisation of D117A and H260A mutations in the melanocortin 1 receptor. Molecular and Cellular Endocrinology. 126: 213-219. PMID 9089659 DOI: 10.1016/S0303-7207(96)03993-7 |
0.434 |
|
| 1997 |
Castrucci AM, Almeida AL, al-Obeidi FA, Hadley ME, Hruby VJ, Staples DJ, Sawyer TK. Comparative biological activities of alpha-MSH antagonists in vertebrate pigment cells. General and Comparative Endocrinology. 105: 410-6. PMID 9073503 DOI: 10.1006/Gcen.1996.6844 |
0.38 |
|
| 1997 |
Jiang J, Sharma SD, Hruby VJ, Fink JL, Hadley ME. Human epidermal melanocyte and keratinocyte melanotropin receptors: visualization by melanotropic peptide conjugated macrospheres (polyamide beads). Experimental Dermatology. 6: 6-12. PMID 9067701 DOI: 10.1111/J.1600-0625.1997.Tb00139.X |
0.409 |
|
| 1997 |
Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385: 165-8. PMID 8990120 DOI: 10.1038/385165A0 |
0.608 |
|
| 1997 |
Shenderovich MD, Kövér KE, Wilke S, Collins N, Hruby VJ. Solution conformations of potent bicyclic antagonists of oxytocin by nuclear magnetic resonance spectroscopy and molecular dynamics simulations Journal of the American Chemical Society. 119: 5833-5846. DOI: 10.1021/Ja963736Y |
0.384 |
|
| 1997 |
Liao S, Lin J, Shenderovich MD, Han Y, Hasohata K, Davis P, Qiu W, Porreca F, Yamamura HI, Hruby VJ. The stereochemical requirements of the novel δ-opioid selective dipeptide antagonist TMT-Tic Bioorganic & Medicinal Chemistry Letters. 7: 3049-3052. DOI: 10.1016/S0960-894X(97)10145-7 |
0.527 |
|
| 1997 |
Lin J, Liao S, Han Y, Qiu W, Hruby VJ. Asymmetric synthesis of all four isomers of topographically constrained novel amino acids: β-isopropyltyrosines Tetrahedron: Asymmetry. 8: 3213-3221. DOI: 10.1016/S0957-4166(97)00381-9 |
0.451 |
|
| 1997 |
Han Y, Liao S, Qiu W, Cai C, Hruby VJ. Total asymmetric synthesis of highly constrained amino acids β-isopropyl-2′,6′-dimethyl-tyrosines Tetrahedron Letters. 38: 5135-5138. DOI: 10.1016/S0040-4039(97)01094-0 |
0.63 |
|
| 1997 |
Yuan W, Hruby VJ. Asymmetric synthesis of unusual amino acid: Synthesis of four isomers of β-methyl-3-(2'-naphthyl)alanine Tetrahedron Letters. 38: 3853-3856. DOI: 10.1016/S0040-4039(97)00770-3 |
0.313 |
|
| 1997 |
Liao S, Shenderovich MD, Lin J, Hruby VJ. Synthesis and conformational features of topographically constrained designer chimeric amino acids: The β-isopropyl phenylalanines Tetrahedron. 53: 16645-16662. DOI: 10.1016/S0040-4020(97)10127-2 |
0.306 |
|
| 1996 |
Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice Pain. 68: 229-237. PMID 9121809 DOI: 10.1016/S0304-3959(96)03185-5 |
0.39 |
|
| 1996 |
Jiang J, Sharma SD, Fink JL, Hadley ME, Hruby VJ. Melanotropic peptide receptors: membrane markers of human melanoma cells. Experimental Dermatology. 5: 325-33. PMID 9028794 DOI: 10.1111/J.1600-0625.1996.Tb00136.X |
0.388 |
|
| 1996 |
Haskell-Luevano C, Sawyer TK, Trumpp-Kallmeyer S, Bikker JA, Humblet C, Gantz I, Hruby VJ. Three-dimensional molecular models of the hMC1R melanocortin receptor: complexes with melanotropin peptide agonists. Drug Design and Discovery. 14: 197-211. PMID 9017363 |
0.619 |
|
| 1996 |
Jiang J, Sharma SD, Hruby VJ, Bentley DL, Fink JL, Hadley ME. Human epidermal melanocyte and keratinocyte melanocortin receptors: visualization by melanotropic peptide conjugated microspheres (latex beads). Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 9: 240-7. PMID 9014210 DOI: 10.1111/J.1600-0749.1996.Tb00113.X |
0.407 |
|
| 1996 |
Hadley ME, Hruby VJ, Jiang J, Sharma SD, Fink JL, Haskell-Luevano C, Bentley DL, al-Obeidi F, Sawyer TK. Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 9: 213-34. PMID 9014208 DOI: 10.1111/J.1600-0749.1996.Tb00111.X |
0.663 |
|
| 1996 |
Sharma SD, Jiang J, Hadley ME, Bentley DL, Hruby VJ. Melanotropic peptide-conjugated beads for microscopic visualization and characterization of melanoma melanotropin receptors. Proceedings of the National Academy of Sciences of the United States of America. 93: 13715-20. PMID 8943000 DOI: 10.1073/Pnas.93.24.13715 |
0.388 |
|
| 1996 |
Haskell-Luevano C, Sawyer TK, Hendrata S, North C, Panahinia L, Stum M, Staples DJ, Castrucci AM, Hadley MF, Hruby VJ. Truncation studies of alpha-melanotropin peptides identify tripeptide analogues exhibiting prolonged agonist bioactivity. Peptides. 17: 995-1002. PMID 8899819 DOI: 10.1016/0196-9781(96)00141-6 |
0.634 |
|
| 1996 |
Qian X, Liao S, Stropova D, Yamamura HI, Hruby VJ. Novel scaffolds for non-peptide mimetics of delta opioid receptor agonists based on peptide leads. Regulatory Peptides. 65: 79-82. PMID 8876039 DOI: 10.1016/0167-0115(96)00075-4 |
0.446 |
|
| 1996 |
Ramaswami V, Zhu X, Romanowski M, Haaseth RC, Misicka A, Lipkowski AW, Hruby VJ, O'Brien DF. Lipid membrane permeability of modified c[D-Pen2, D-Pen5]enkephalin peptides International Journal of Peptide and Protein Research. 48: 87-94. PMID 8844267 DOI: 10.1111/J.1399-3011.1996.Tb01110.X |
0.356 |
|
| 1996 |
Boteju LW, Nikiforovich GV, Haskell-Luevano C, Fang SN, Zalewska T, Stropova D, Yamamura HI, Hruby VJ. The use of topographical constraints in receptor mapping: investigation of the topographical requirements of the tryptophan 30 residue for receptor binding of Asp-Tyr-D-Phe-Gly-Trp-(N-Me)Nle-Asp-Phe-NH2 (SNF 9007), a cholecystokinin (26-33) analogue that binds to both CCK-B and delta-opioid receptors. Journal of Medicinal Chemistry. 39: 4120-4. PMID 8831778 DOI: 10.1021/Jm960078J |
0.691 |
|
| 1996 |
Misicka A, Maszczynska I, Lipkowski AW, Stropova D, Yamamura HI, Hruby VJ. Synthesis and biological properties of gamma-glutamyl-dermorphin, a prodrug. Life Sciences. 58: 905-11. PMID 8786696 DOI: 10.1016/0024-3205(96)00033-1 |
0.381 |
|
| 1996 |
Williams SA, Abbruscato TJ, Hruby VJ, Davis TP. Passage of a delta-opioid receptor selective enkephalin, [D-penicillamine2,5] enkephalin, across the blood-brain and the blood-cerebrospinal fluid barriers. Journal of Neurochemistry. 66: 1289-99. PMID 8769896 DOI: 10.1046/J.1471-4159.1996.66031289.X |
0.303 |
|
| 1996 |
Van Tine BA, Azizeh BY, Trivedi D, Phelps JR, Houslay MD, Johnson DG, Hruby VJ. Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists. Endocrinology. 137: 3316-22. PMID 8754757 DOI: 10.1210/Endo.137.8.8754757 |
0.388 |
|
| 1996 |
Roerig SC, Williams CL, Hruby VJ, Burks TF, Rosenfeld GC. Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells. Regulatory Peptides. 61: 51-6. PMID 8701027 DOI: 10.1016/0167-0115(95)00137-9 |
0.443 |
|
| 1996 |
Lung FD, Meyer JP, Lou BS, Xiang L, Li G, Davis P, DeLeon IA, Yamamura HI, Porreca F, Hruby VJ. Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency. Journal of Medicinal Chemistry. 39: 2456-60. PMID 8691442 DOI: 10.1021/jm950655o |
0.386 |
|
| 1996 |
Azizeh BY, Shenderovich MD, Trivedi D, Li G, Sturm NS, Hruby VJ. Topographical amino acid substitution in position 10 of glucagon leads to antagonists/partial agonists with greater binding differences. Journal of Medicinal Chemistry. 39: 2449-55. PMID 8691441 DOI: 10.1021/Jm960130B |
0.395 |
|
| 1996 |
Tourwé D, Verschueren K, Frycia A, Davis P, Porreca F, Hruby VJ, Toth G, Jaspers H, Verheyden P, Van Binst G. Conformational restriction of Tyr and Phe side chains in opioid peptides: information about preferred and bioactive side-chain topology. Biopolymers. 38: 1-12. PMID 8679939 DOI: 10.1002/(Sici)1097-0282(199601)38:1<1::Aid-Bip1>3.0.Co;2-# |
0.402 |
|
| 1996 |
Lung FD, Collins N, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2. Journal of Medicinal Chemistry. 39: 1136-41. PMID 8676350 DOI: 10.1021/Jm950369C |
0.509 |
|
| 1996 |
Ossipov MH, Kovelowski CJ, Nichols ML, Hruby VJ, Porreca F. Characterization of supraspinal antinociceptive actions of opioid delta agonists in the rat. Pain. 62: 287-93. PMID 8657428 DOI: 10.1016/0304-3959(94)00231-3 |
0.401 |
|
| 1996 |
Liwo A, Tempczyk A, Ołdziej S, Shenderovich MD, Hruby VJ, Talluri S, Ciarkowski J, Kasprzykowski F, Lankiewicz L, Grzonka Z. Exploration of the conformational space of oxytocin and arginine-vasopressin using the electrostatically driven Monte Carlo and molecular dynamics methods. Biopolymers. 38: 157-75. PMID 8589250 DOI: 10.1002/(Sici)1097-0282(199602)38:2<157::Aid-Bip3>3.0.Co;2-U |
0.319 |
|
| 1996 |
Shenderovich MD, Kövér KE, Nikiforovich GV, Jiao D, Hruby VJ. Conformational analysis of beta-methyl-para-nitrophenylalanine stereoisomers of cyclo[D-Pen2, D-Pen5]enkephalin by NMR spectroscopy and conformational energy calculations. Biopolymers. 38: 141-56. PMID 8589249 DOI: 10.1002/(Sici)1097-0282(199602)38:2<141::Aid-Bip2>3.0.Co;2-V |
0.358 |
|
| 1996 |
Haskell-Luevano C, Miwa H, Dickinson C, Hadley ME, Hruby VJ, Yamada T, Gantz I. Characterizations of the unusual dissociation properties of melanotropin peptides from the melanocortin receptor, hMC1R. Journal of Medicinal Chemistry. 39: 432-5. PMID 8558511 DOI: 10.1021/Jm950407S |
0.619 |
|
| 1996 |
Kazmierski WM, Ferguson RD, Lipkowski AW, Hruby VJ. A topographical model of mu-opioid and brain somatostatin receptor selective ligands. NMR and molecular dynamics studies. International Journal of Peptide and Protein Research. 46: 265-78. PMID 8537180 DOI: 10.1111/J.1399-3011.1995.Tb00598.X |
0.474 |
|
| 1996 |
Li S, Varga K, Archer P, Hruby VJ, Sharma SD, Kesterson RA, Cone RD, Kunos G. Melanocortin Antagonists Define Two Distinct Pathways of Cardiovascular Control by α- and γ-Melanocyte-Stimulating Hormones The Journal of Neuroscience. 16: 5182-5188. DOI: 10.1523/Jneurosci.16-16-05182.1996 |
0.586 |
|
| 1996 |
Flippen-Anderson JL, Deschamps J, George C, Hruby VJ, Li G, Lipkowski AW, Misicka A. Biphalin, a highly potent dimeric enkephalin analog Acta Crystallographica Section a Foundations of Crystallography. 52: C253-C253. DOI: 10.1107/S0108767396089325 |
0.37 |
|
| 1996 |
Qian X, Shenderovich MD, Kover KE, Davis P, Horvath R, Zalewska T, Yamamura HI, Porreca F, Hruby VJ. Probing the stereochemical requirements for receptor recognition of δ opioid agonists through topographic modifications in position 1 Journal of the American Chemical Society. 118: 7280-7290. DOI: 10.1021/Ja954241W |
0.457 |
|
| 1996 |
Collins N, Flippen-Anderson JL, Haaseth RC, Deschamps JR, George C, Kövér K, Hruby VJ. Conformational Determinants of Agonist versus Antagonist Properties of [d-Pen2,d-Pen5]Enkephalin (DPDPE) Analogs at Opioid Receptors. Comparison of X-ray Crystallographic Structure, Solution1H NMR Data, and Molecular Dynamic Simulations of [l-Ala3]DPDPE and [d-Ala3]DPDPE Journal of the American Chemical Society. 118: 2143-2152. DOI: 10.1021/Ja9531081 |
0.442 |
|
| 1995 |
Jiang J, Sharma SD, Nakamura S, Lai JY, Fink JL, Hruby VJ, Hadley ME. The melanotropic peptide, [Nle4,D-Phe7] alpha-MSH, stimulates human melanoma tyrosinase activity and inhibits cell proliferation. Pigment Cell Research / Sponsored by the European Society For Pigment Cell Research and the International Pigment Cell Society. 8: 314-23. PMID 8789740 DOI: 10.1111/J.1600-0749.1995.Tb00680.X |
0.314 |
|
| 1995 |
Knapp RJ, Landsman R, Waite S, Malatynska E, Varga E, Haq W, Hruby VJ, Roeske WR, Nagase H, Yamamura HI. Properties of TAN-67, a nonpeptidic delta-opioid receptor agonist, at cloned human delta- and mu-opioid receptors. European Journal of Pharmacology. 291: 129-34. PMID 8566162 DOI: 10.1016/0922-4106(95)90134-5 |
0.465 |
|
| 1995 |
Meyer JP, Gillespie TJ, Hom S, Hruby VJ, Davis TP. In vitro stability of some reduced peptide bond pseudopeptide analogues of dynorphin A. Peptides. 16: 1215-9. PMID 8545241 DOI: 10.1016/0196-9781(95)02005-H |
0.316 |
|
| 1995 |
Lung FD, Meyer JP, Li G, Lou BS, Stropova D, Davis P, Yamamura HI, Porreca F, Hruby VJ. Highly kappa receptor-selective dynorphin A analogues with modifications in position 3 of dynorphin A(1-11)-NH2. Journal of Medicinal Chemistry. 38: 585-6. PMID 7861405 DOI: 10.1021/Jm00004A002 |
0.424 |
|
| 1995 |
Slaninova J, Knapp RJ, Weber SJ, Davis TP, Fang SN, Hruby VJ, Yamamura HI. [125I]SNF 8702: a selective radioligand for CCKB receptors. Peptides. 16: 221-4. PMID 7784252 DOI: 10.1016/0196-9781(94)00168-5 |
0.4 |
|
| 1995 |
Haskell-Luevano C, Shenderovich MD, Sharma SD, Nikiforovich GV, Hadley ME, Hruby VJ. Design, synthesis, biology, and conformations of bicyclic alpha-melanotropin analogues. Journal of Medicinal Chemistry. 38: 1736-50. PMID 7752197 DOI: 10.1021/Jm00010A018 |
0.63 |
|
| 1995 |
Knapp RJ, Malatynska E, Collins N, Fang L, Wang JY, Hruby VJ, Roeske WR, Yamamura HI. Molecular biology and pharmacology of cloned opioid receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 516-25. PMID 7737460 DOI: 10.1096/Fasebj.9.7.7737460 |
0.46 |
|
| 1995 |
Meyer JP, Davis P, Lee KB, Porreca F, Yamamura HI, Hruby VJ. Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1. Journal of Medicinal Chemistry. 38: 3462-8. PMID 7658433 DOI: 10.1021/Jm00018A006 |
0.482 |
|
| 1995 |
Hruby VJ, Lu D, Sharma SD, Castrucci AL, Kesterson RA, al-Obeidi FA, Hadley ME, Cone RD. Cyclic lactam alpha-melanotropin analogues of Ac-Nle4-cyclo[Asp5, D-Phe7,Lys10] alpha-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. Journal of Medicinal Chemistry. 38: 3454-61. PMID 7658432 DOI: 10.1021/Jm00018A005 |
0.632 |
|
| 1995 |
Hruby VJ, Yamamura HI, Porreca F. Molecular organization of receptors. Efficacy, agonists, and antagonists. Annals of the New York Academy of Sciences. 757: 7-22. PMID 7611710 DOI: 10.1111/J.1749-6632.1995.Tb17461.X |
0.383 |
|
| 1995 |
Misicka A, Lipkowski AW, Slaninova J, Davis P, Yamamura HI, Porreca F, Hruby VJ. The synthesis and opioid receptor binding affinities of analogues of dermorphin and its N-terminal tetrapeptide fragment with dibasic acids in position 2. Life Sciences. 57: 1633-40. PMID 7475903 DOI: 10.1016/0024-3205(95)02142-6 |
0.455 |
|
| 1995 |
Haskell-Luevano C, Boteju LW, Miwa H, Dickinson C, Gantz I, Yamada T, Hadley ME, Hruby VJ. Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities. Journal of Medicinal Chemistry. 38: 4720-9. PMID 7473600 DOI: 10.1021/Jm00023A012 |
0.647 |
|
| 1995 |
Hruby VJ, Davis T, Polt R, Porreca F, O’Brien D, Yamamura H, Bartosz H, Szabo L, Gillespie T, Williams S, Misicka A, Lipkowski A, Qian X, Li G, Patel D, et al. DESIGN AND SYNTHESIS OF PEPTIDE LIGANDS WITH UNIQUE BIOCHEMICAL AND BIOLOGICAL PROFILES AT OPIOID RECEPTORS THAT CROSS THE BLOOD BRAIN BARRIER Analgesia. 1: 469-472. DOI: 10.3727/107156995819562961 |
0.336 |
|
| 1995 |
Azizeh BY, Van Tine BA, Sturm NS, Hutzler AM, David C, Trivedi D, Hruby VJ. [des His1, des Phe6, Glu9]glucagon amide: A newly designed "pure" glucagon antagonist Bioorganic and Medicinal Chemistry Letters. 5: 1849-1852. DOI: 10.1016/0960-894X(95)00307-F |
0.419 |
|
| 1995 |
Qian X, Russell KC, Boteju LW, Hruby VJ. Stereoselective total synthesis of topographically constrained designer amino acids: 2′, 6′-dimethyl-β-methyltyrosines Tetrahedron. 51: 1033-1054. DOI: 10.1016/0040-4020(94)00996-8 |
0.373 |
|
| 1995 |
Misicka A, Lipkowski AW, Stropova D, Davis P, Porreca F, Yamamura HI, Hruby VJ. Amino acids with amphiphilic side chains: Deltorphin analogues with Phe3 replaced by all β-hydroxyphenylalanine diastereoisomers Letters in Peptide Science. 2: 203-205. DOI: 10.1007/Bf00119153 |
0.374 |
|
| 1995 |
Lipkowski AW, Misicka A, Porreca F, Davis P, Yamamura HI, Stropova D, Hruby VJ. Benzomorphan alkaloids: Natural peptidomimetics of opioid peptide pharmacophores Letters in Peptide Science. 2: 177-181. DOI: 10.1007/Bf00119147 |
0.451 |
|
| 1995 |
Haskell-Luevano C, Boteju LW, Hruby VJ. Facile removal of the N-indole-mesitylenesulfonyl protecting group using HF cleavage conditions Letters in Peptide Science. 1: 163-170. DOI: 10.1007/Bf00117952 |
0.611 |
|
| 1994 |
Bartosz-Bechowski H, Davis P, Zalewska T, Slaninova J, Porreca F, Yamamura HI, Hruby VJ. Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors. Journal of Medicinal Chemistry. 37: 146-50. PMID 8289188 DOI: 10.1021/Jm00027A018 |
0.477 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Yamamura HI, Porreca F, Hruby VJ. Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. Journal of Medicinal Chemistry. 37: 141-5. PMID 8289187 DOI: 10.1021/Jm00027A017 |
0.465 |
|
| 1994 |
Knapp RJ, Malatynska E, Fang L, Li X, Babin E, Nguyen M, Santoro G, Varga EV, Hruby VJ, Roeske WR. Identification of a human delta opioid receptor: cloning and expression. Life Sciences. 54: PL463-9. PMID 8201839 DOI: 10.1016/0024-3205(94)90138-4 |
0.472 |
|
| 1994 |
Knapp RJ, Malatynska E, Hashimoto S, Fang S, Hunt M, Wamsley JK, Peterson P, Zalewska T, Hruby VJ, Yamamura HI. [3H]SNF8702 autoradiography of CCK-B receptors in guinea pig brain and studies with a cloned rat CCK-B receptor. Annals of the New York Academy of Sciences. 713: 380-3. PMID 8185194 DOI: 10.1111/J.1749-6632.1994.Tb44099.X |
0.323 |
|
| 1994 |
Vanderah T, Takemori AE, Sultana M, Portoghese PS, Mosberg HI, Hruby VJ, Haaseth RC, Matsunaga TO, Porreca F. Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo. European Journal of Pharmacology. 252: 133-7. PMID 8157053 DOI: 10.1016/0014-2999(94)90588-6 |
0.431 |
|
| 1994 |
Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/Pnas.91.15.7114 |
0.368 |
|
| 1994 |
Bilsky EJ, Bernstein RN, Pasternak GW, Hruby VJ, Patel D, Porreca F, Lai J. Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor Life Sciences. 55: PL37-PL43. PMID 8015351 DOI: 10.1016/0024-3205(94)90110-4 |
0.393 |
|
| 1994 |
Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T, Gantz I. Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochemical and Biophysical Research Communications. 204: 1137-42. PMID 7980588 DOI: 10.1006/Bbrc.1994.2581 |
0.592 |
|
| 1994 |
Meyer JP, Collins N, Lung FD, Davis P, Zalewska T, Porreca F, Yamamura HI, Hruby VJ. Design, synthesis, and biological properties of highly potent cyclic dynorphin A analogues. Analogues cyclized between positions 5 and 11. Journal of Medicinal Chemistry. 37: 3910-7. PMID 7966152 DOI: 10.1021/Jm00049A010 |
0.419 |
|
| 1994 |
Collins N, Hruby VJ. Prediction of the conformational requirements for binding to the κ‐opioid receptor and its subtypes. I. Novel α‐helical cyclic peptides and their role in receptor selectivity Biopolymers. 34: 1231-1241. PMID 7948735 DOI: 10.1002/Bip.360340911 |
0.422 |
|
| 1994 |
Hruby VJ, Qian X. Approaches to the asymmetric synthesis of unusual amino acids Methods in Molecular Biology (Clifton, N.J.). 35: 249-286. PMID 7894604 DOI: 10.1385/0-89603-273-6:249 |
0.337 |
|
| 1994 |
Hruby VJ, Bonner GG. Design of novel synthetic peptides including cyclic conformationally and topographically constrained analogs Methods in Molecular Biology (Clifton, N.J.). 35: 201-240. PMID 7894602 DOI: 10.1385/0-89603-273-6:201 |
0.352 |
|
| 1994 |
Sharma SD, Granberry ME, Jiang J, Leong SPL, Hadley ME, Hruby VJ. Multivalent Melanotropic Peptide and Fluorescent Macromolecular Conjugates: New Reagents for Characterization of Melanotropin Receptors Bioconjugate Chemistry. 5: 591-601. PMID 7873662 DOI: 10.1021/Bc00030A015 |
0.42 |
|
| 1994 |
Knapp RJ, Malatynska E, Peterson P, Zalewska T, Fang S, Hruby VJ, Smith TL, Yamamura HI. [N-methylnorleucine-(28,31)]cholecystokinin-(26-33) (SNF 8702) activity at a cloned rat CCKB receptor. European Journal of Pharmacology. 269: 133-8. PMID 7851490 DOI: 10.1016/0922-4106(94)90079-5 |
0.425 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Delta opioid receptor selective ligands; DPLPE-deltorphin chimeric peptide analogues. International Journal of Peptide and Protein Research. 44: 80-4. PMID 7718035 DOI: 10.1111/J.1399-3011.1994.Tb00407.X |
0.503 |
|
| 1994 |
Li G, Patel D, Hruby VJ. Exploration for large-scale stereoselective synthesis of unusual amino acids by using 4-phenyloxazolidin-2-one as a new chiral resolution reagent Journal of the Chemical Society-Perkin Transactions 1. 3057-3059. DOI: 10.1039/P19940003057 |
0.32 |
|
| 1994 |
Kazmierski WM, Urbanczyk-Lipkowska Z, Hruby VJ. New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of .alpha.,.beta.-Dimethylphenylalanine and .alpha.,.beta.-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity The Journal of Organic Chemistry. 59: 1789-1795. DOI: 10.1021/Jo00086A033 |
0.357 |
|
| 1994 |
Flippen-Anderson JL, Hruby VJ, Collins N, George C, Cudney B. X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, .delta. Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Journal of the American Chemical Society. 116: 7523-7531. DOI: 10.1021/Ja00096A008 |
0.391 |
|
| 1994 |
Matsunaga TO, Collins N, Ramaswami V, Yamamura SH, O'Brien DF, Hruby VJ. Comparison of the membrane-bound states of two structurally similar .delta.-selective opioid peptides by transferred nuclear Overhauser effect spectroscopy and molecular modeling. [Erratum to document cited in CA119(25):262678y] Biochemistry. 33: 5356-5356. DOI: 10.1021/Bi00183A044 |
0.346 |
|
| 1994 |
Boteju LW, Wegner K, Qian X, Hruby VJ. Asymmetric synthesis of unusual amino acids: Synthesis of optically pure isomers of N-indole- (2-mesitylenesulfonyl)-β-methyltryptophan Tetrahedron. 50: 2391-2404. DOI: 10.1016/S0040-4020(01)86957-X |
0.332 |
|
| 1994 |
Hruby VJ, Wilke S, Al-Obeidi F, Jiao D, Lin Y. Strategies for cyclizations of novel peptides on solid supports Reactive Polymers. 22: 231-241. DOI: 10.1016/0923-1137(94)90121-X |
0.362 |
|
| 1994 |
Hruby VJ, Collins N, Lung FD, Meyer JP, Davis TP, Yamamura HI, Porreca F. Design of peptides and peptidomimetics for delta and kappa opioid receptor subtypes Regulatory Peptides. 54: 123-124. DOI: 10.1016/0167-0115(94)90420-0 |
0.455 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Structure-activity relationships of analogues of higly potent opioid peptide, biphalin Regulatory Peptides. 53: S131-S132. DOI: 10.1016/0167-0115(94)90276-3 |
0.497 |
|
| 1994 |
Misicka A, Lipkowski AW, Horvath R, Davis P, Porreca F, Yamamura HI, Hruby VJ. Topographic model of delta opioid selective ligands; DPLPE-deltorphin hybrid analogues Regulatory Peptides. 53: S129-S130. DOI: 10.1016/0167-0115(94)90275-5 |
0.479 |
|
| 1994 |
Hruby VJ, Misicka A, Lipkowski AW, Haaseth R, Bartosz H, Qian X, Collins N, Meyer JP, Szabo L, Polt R, Porreca F, Davis T, Yamamura HI. New opioid compounds in analgesia Regulatory Peptides. 53: S71-S72. DOI: 10.1016/0167-0115(94)90246-1 |
0.495 |
|
| 1994 |
Li G, Patel D, Hruby VJ. 1, 2-Asymmetric cis induction and its application to the asymmetric synthesis of precursors of β-branched unusual amino acids Tetrahedron Letters. 35: 2301-2304. DOI: 10.1016/0040-4039(94)85204-9 |
0.303 |
|
| 1993 |
Mollova NN, Schram KH, Lin Y, Dharanipragada R, Hruby VJ. Characterization of linear and cyclic glucagon analogs by fast atom bombardment mass spectrometry. Biological Mass Spectrometry. 22: 267-76. PMID 8507672 DOI: 10.1002/Bms.1200220502 |
0.302 |
|
| 1993 |
Nikiforovich GV, Prakash OM, Gehrig CA, Hruby VJ. Solution conformations of the peptide backbone for DPDPE and its beta-MePhe4-substituted analogs. International Journal of Peptide and Protein Research. 41: 347-61. PMID 8496017 DOI: 10.1111/J.1399-3011.1993.Tb00451.X |
0.375 |
|
| 1993 |
Hruby VJ, Gysin B, Trivedi D, Johnson DG. New glucagon analogues with conformational restrictions and altered amphiphilicity: effects on binding, adenylate cyclase and glycogenolytic activities. Life Sciences. 52: 845-55. PMID 8445980 DOI: 10.1016/0024-3205(93)90513-3 |
0.441 |
|
| 1993 |
Dharanipragada R, Trivedi D, Bannister A, Siegel M, Tourwe D, Mollova N, Schram K, Hruby VJ. Synthetic linear and cyclic glucagon antagonists. International Journal of Peptide and Protein Research. 42: 68-77. PMID 8396562 DOI: 10.1111/J.1399-3011.1993.TB00352.X |
0.345 |
|
| 1993 |
Wild KD, Horan PJ, Misicka A, Lipkowski A, Haaseth RC, Matsunaga TO, Hruby VJ, Toth G, Borsodi A, Yamamura HI. Pseudoirreversible binding characteristics of [D-Ala2,Glu4]deltorphin and its Cys4 substituted derivative to delta-opioid receptors. European Journal of Pharmacology. 246: 25-31. PMID 8394818 DOI: 10.1016/0922-4106(93)90005-T |
0.421 |
|
| 1993 |
Sawyer TK, Castrucci AM, Staples DJ, Affholter JA, De Vaux A, Hruby VJ, Hadley ME. Structure-activity relationships of [Nle4, D-Phe7]alpha-MSH. Discovery of a tripeptidyl agonist exhibiting sustained bioactivity. Annals of the New York Academy of Sciences. 680: 597-9. PMID 8390200 DOI: 10.1111/J.1749-6632.1993.Tb19749.X |
0.319 |
|
| 1993 |
Hruby VJ, Sharma SD, Toth K, Jaw JY, al-Obeidi F, Sawyer TK, Hadley ME. Design, synthesis, and conformation of superpotent and prolonged acting melanotropins. Annals of the New York Academy of Sciences. 680: 51-63. PMID 8390180 DOI: 10.1111/J.1749-6632.1993.Tb19674.X |
0.316 |
|
| 1993 |
Horan PJ, Wild KD, Kazmierski WM, Ferguson R, Hruby VJ, Weber SJ, Davis TP, Fang L, Knapp RJ, Yamamura HI. Unexpected antinociceptive potency of cyclic [D-Tca1]CTAP: potential for a novel mechanism of action. European Journal of Pharmacology. 233: 53-62. PMID 8386089 DOI: 10.1016/0014-2999(93)90348-L |
0.429 |
|
| 1993 |
Lippens G, Hallenga K, Van Belle D, Wodak SJ, Nirmala NR, Hill P, Russell KC, Smith DD, Hruby VJ. Transfer nuclear Overhauser effect study of the conformation of oxytocin bound to bovine neurophysin I. Biochemistry. 32: 9423-34. PMID 8369312 DOI: 10.1021/Bi00087A022 |
0.303 |
|
| 1993 |
Nikiforovich GV, Hruby VJ. Models for the A- and B-Receptor-Bound Conformations of CCK-8 Biochemical and Biophysical Research Communications. 194: 9-16. PMID 8333874 DOI: 10.1006/Bbrc.1993.1777 |
0.432 |
|
| 1993 |
Matsunaga TO, Collins N, Ramaswami V, Yamamura SH, O'Brien DF, Hruby VJ. Comparison of the membrane-bound states of two structurally similar delta-selective opioid peptides by transferred nuclear Overhauser effect spectroscopy and molecular modeling. Biochemistry. 32: 13180-9. PMID 8241172 DOI: 10.1021/Bi00211A029 |
0.329 |
|
| 1993 |
Ito AS, Castrucci AMDL, Hruby VJ, Hadley ME, Krajcarski DT, Szabo AG. Structure-activity correlations of melanotropin peptides in model lipids by tryptophan fluorescence studies Biochemistry. 32: 12264-12272. PMID 8218305 DOI: 10.1021/Bi00096A041 |
0.337 |
|
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