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Andrea LeBlanc - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Neuroscience Biology
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhou L, Nho K, Haddad MG, Cherepacha N, Tubeleviciute-Aydin A, Tsai AP, Saykin AJ, Jesper Sjöström P, LeBlanc AC. Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration. Scientific Reports. 11: 12695. PMID 34135352 DOI: 10.1038/s41598-021-91367-0  0.336
2020 Flores J, Noël A, Foveau B, Beauchet O, LeBlanc AC. Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging. Nature Communications. 11: 4571. PMID 32917871 DOI: 10.1038/s41467-020-18405-9  0.317
2019 Zhou L, Flores J, Noël A, Beauchet O, Sjöström PJ, LeBlanc AC. Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice. Acta Neuropathologica Communications. 7: 210. PMID 31843022 DOI: 10.1186/s40478-019-0856-6  0.302
2019 Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC. Identification of Allosteric Inhibitors against Active Caspase-6. Scientific Reports. 9: 5504. PMID 30940883 DOI: 10.1038/S41598-019-41930-7  0.316
2019 Foveau B, Correia AS, Hébert SS, Rainone S, Potvin O, Kergoat MJ, Belleville S, Duchesne S, LeBlanc AC. Stem Cell-Derived Neurons as Cellular Models of Sporadic Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30689579 DOI: 10.3233/Jad-180833  0.364
2018 Flores J, Noël A, Foveau B, Lynham J, Lecrux C, LeBlanc AC. Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model. Nature Communications. 9: 3916. PMID 30254377 DOI: 10.1038/s41467-018-06449-x  0.304
2018 Noël A, Zhou L, Foveau B, Sjöström PJ, LeBlanc AC. Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6. Cell Death and Differentiation. PMID 29352267 DOI: 10.1038/s41418-017-0043-x  0.385
2017 Victor KG, Heffron DS, Sokolowski JD, Majumder U, Leblanc A, Mandell JW. Proteomic Identification of Synaptic Caspase Substrates. Synapse (New York, N.Y.). PMID 28960461 DOI: 10.1002/Syn.22014  0.435
2017 Pakavathkumar P, Noël A, Lecrux C, Tubeleviciute-Aydin A, Hamel E, Ahlfors JE, LeBlanc AC. Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice. Molecular Neurodegeneration. 12: 22. PMID 28241839 DOI: 10.1186/S13024-017-0166-Z  0.383
2015 Pakavathkumar P, Sharma G, Kaushal V, Foveau B, LeBlanc AC. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Scientific Reports. 5: 13730. PMID 26400108 DOI: 10.1038/srep13730  0.326
2013 LeBlanc AC. Caspase-6 as a novel early target in the treatment of Alzheimer's disease. The European Journal of Neuroscience. 37: 2005-18. PMID 23773070 DOI: 10.1111/ejn.12250  0.314
2012 Kaushal V, LeBlanc A. Inflammasome-mediated activation of caspase-1 and caspase-6 in primary human neurons Alzheimers & Dementia. 8: 303. DOI: 10.1016/J.Jalz.2012.05.825  0.446
2012 Pakavathkumar P, Ahlfors J, LeBlanc A. Evaluation of a novel caspase-6 inhibitor as a potential treatment for Alzheimer's disease Alzheimers & Dementia. 8: 601. DOI: 10.1016/J.Jalz.2012.05.2088  0.36
2010 Lee AW, Champagne N, Wang X, Su XD, Goodyer C, Leblanc AC. Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A. The Journal of Biological Chemistry. 285: 31974-84. PMID 20682790 DOI: 10.1074/jbc.M110.152744  0.339
2010 Albrecht S, Bogdanovic N, Ghetti B, Winblad B, Leblanc A. Erratum: Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or pesenilin I or presenilin II mutations (Journal of Neuropathology and Experimental Neurology (2009) 68 (1282-1293) Journal of Neuropathology and Experimental Neurology. 69. DOI: 10.1097/Nen.0B013E3181Cf7162  0.372
2008 Klaiman G, Petzke TL, Hammond J, Leblanc AC. Targets of caspase-6 activity in human neurons and Alzheimer disease. Molecular & Cellular Proteomics : McP. 7: 1541-55. PMID 18487604 DOI: 10.1074/mcp.M800007-MCP200  0.444
2007 Albrecht S, Bourdeau M, Bennett D, Mufson EJ, Bhattacharjee M, LeBlanc AC. Activation of caspase-6 in aging and mild cognitive impairment. The American Journal of Pathology. 170: 1200-9. PMID 17392160 DOI: 10.2353/Ajpath.2007.060974  0.358
2007 Jain P, Cerone MA, Leblanc AC, Autexier C. Telomerase and neuronal marker status of differentiated NT2 and SK-N-SH human neuronal cells and primary human neurons. Journal of Neuroscience Research. 85: 83-9. PMID 17075923 DOI: 10.1002/Jnr.21094  0.311
2006 Bounhar Y, Mann KK, Roucou X, LeBlanc AC. Prion protein prevents Bax-mediated cell death in the absence of other Bcl-2 family members in Saccharomyces cerevisiae. Fems Yeast Research. 6: 1204-12. PMID 17156017 DOI: 10.1111/J.1567-1364.2006.00122.X  0.309
2005 LeBlanc AC. The role of apoptotic pathways in Alzheimer's disease neurodegeneration and cell death. Current Alzheimer Research. 2: 389-402. PMID 16248844 DOI: 10.2174/156720505774330573  0.373
2005 Roucou X, Giannopoulos PN, Zhang Y, Jodoin J, Goodyer CG, LeBlanc A. Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells Cell Death and Differentiation. 12: 783-795. PMID 15846375 DOI: 10.1038/Sj.Cdd.4401629  0.408
2004 Guo H, Albrecht S, Bourdeau M, Petzke T, Bergeron C, LeBlanc AC. Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease. The American Journal of Pathology. 165: 523-31. PMID 15277226 DOI: 10.1016/S0002-9440(10)63317-2  0.477
2004 Zhang Y, Champagne N, Beitel LK, Goodyer CG, Trifiro M, LeBlanc A. Estrogen and androgen protection of human neurons against intracellular amyloid beta1-42 toxicity through heat shock protein 70. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5315-21. PMID 15190103 DOI: 10.1523/JNEUROSCI.0913-04.2004  0.342
2004 Tounekti O, Zhang Y, Klaiman G, Goodyer CG, LeBlanc A. Proteasomal degradation of caspase-6 in 17beta-estradiol-treated neurons. Journal of Neurochemistry. 89: 561-8. PMID 15086513 DOI: 10.1111/j.1471-4159.2004.02349.x  0.318
2004 Gouras G, LaFerla F, Strobel G, Busciglio J, Almeida C, Geula C, Stenh C, Lee D, D'Andrea M, Nagele B, Takahashi R, Hartmann T, LeBlanc A, Dineley K, Koudinov A. Intraneuronal Aβ accumulation-more evidence, less controversy? Alzheimer research forum live discussion Journal of Alzheimer's Disease. 6: 443-449. DOI: 10.3233/Jad-2004-6413  0.325
2003 Roucou X, Guo Q, Zhang Y, Goodyer CG, LeBlanc AC. Cytosolic prion protein is not toxic and protects against Bax-mediated cell death in human primary neurons. The Journal of Biological Chemistry. 278: 40877-81. PMID 12917444 DOI: 10.1074/Jbc.M306177200  0.4
2003 Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7385-94. PMID 12917374 DOI: 10.1523/Jneurosci.23-19-07385.2003  0.445
2003 LeBlanc AC. Natural cellular inhibitors of caspases. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 215-29. PMID 12657361 DOI: 10.1016/S0278-5846(03)00017-4  0.313
2002 Zhang Y, McLaughlin R, Goodyer C, LeBlanc A. Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. The Journal of Cell Biology. 156: 519-29. PMID 11815632 DOI: 10.1083/Jcb.200110119  0.455
2001 Bounhar Y, Zhang Y, Goodyer CG, LeBlanc A. Prion Protein Protects Human Neurons against Bax-mediated Apoptosis Journal of Biological Chemistry. 276: 39145-39149. PMID 11522774 DOI: 10.1074/Jbc.C100443200  0.457
2001 Hammond J, Le Q, Goodyer C, Gelfand M, Trifiro M, LeBlanc A. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. Journal of Neurochemistry. 77: 1319-1326. PMID 11389183 DOI: 10.1046/J.1471-4159.2001.00345.X  0.401
1999 LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J. Caspase-6 Role in Apoptosis of Human Neurons, Amyloidogenesis, and Alzheimer’s Disease Journal of Biological Chemistry. 274: 23426-23436. PMID 10438520 DOI: 10.1074/Jbc.274.33.23426  0.537
1996 Paradis E, Douillard H, Koutroumanis M, Goodyer C, LeBlanc A. Amyloid β Peptide of Alzheimer’s Disease Downregulates Bcl-2 and Upregulates Bax Expression in Human Neurons The Journal of Neuroscience. 16: 7533-7539. DOI: 10.1523/Jneurosci.16-23-07533.1996  0.5
1995 Lee S, LeBlanc A, Duttaroy A, Wang E. Terminal Differentiation-Dependent Alteration in the Expression of Translation Elongation Factor-1α and Its Sister Gene, S1, in Neurons Experimental Cell Research. 219: 589-597. PMID 7641810 DOI: 10.1006/Excr.1995.1268  0.311
1995 LeBlanc A. Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis The Journal of Neuroscience. 15: 7837-7846. DOI: 10.1523/Jneurosci.15-12-07837.1995  0.443
1994 LeBlanc A. The role of β-amyloid peptide in alzheimer's disease Metabolic Brain Disease. 9: 3-31. PMID 8058028 DOI: 10.1007/Bf01996071  0.348
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