| Year |
Citation |
Score |
| 2024 |
Bai D, Deng F, Jia Q, Ou K, Wang X, Hou J, Zhu L, Guo M, Yang S, Jiang G, Li S, Li XJ, Yin P. Pathogenic TDP-43 accelerates the generation of toxic exon1 HTT in Huntington's disease knock-in mice. Aging Cell. e14325. PMID 39185703 DOI: 10.1111/acel.14325 |
0.374 |
|
| 2024 |
Qin Y, Zhu W, Guo T, Zhang Y, Xing T, Yin P, Li S, Li XJ, Yang S. Reduced mesencephalic astrocyte-derived neurotrophic factor expression by mutant androgen receptor contributes to neurodegeneration in a model of spinal and bulbar muscular atrophy pathology. Neural Regeneration Research. PMID 38934406 DOI: 10.4103/NRR.NRR-D-23-01666 |
0.386 |
|
| 2024 |
Qin Y, Chen L, Zhu W, Song J, Lin J, Li Y, Zhang J, Song X, Xing T, Guo T, Duan X, Zhang Y, Ruan E, Wang Q, Li B, ... ... Li XJ, et al. TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington's disease. Science Advances. 10: eadl2036. PMID 38758800 DOI: 10.1126/sciadv.adl2036 |
0.455 |
|
| 2024 |
Chen L, Qin Y, Guo T, Zhu W, Lin J, Xing T, Duan X, Zhang Y, Ruan E, Li X, Yin P, Li S, Li XJ, Yang S. HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice. Cell Death & Disease. 15: 337. PMID 38744826 DOI: 10.1038/s41419-024-06716-4 |
0.468 |
|
| 2024 |
Tong H, Yang T, Xu S, Li X, Liu L, Zhou G, Yang S, Yin S, Li XJ, Li S. Huntington's Disease: Complex Pathogenesis and Therapeutic Strategies. International Journal of Molecular Sciences. 25. PMID 38612657 DOI: 10.3390/ijms25073845 |
0.357 |
|
| 2024 |
Zhu L, Deng F, Bai D, Hou J, Jia Q, Zhang C, Ou K, Li S, Li XJ, Yin P. Loss of TDP-43 mediates severe neurotoxicity by suppressing PJA1 gene transcription in the monkey brain. Cellular and Molecular Life Sciences : Cmls. 81: 16. PMID 38194085 DOI: 10.1007/s00018-023-05066-2 |
0.324 |
|
| 2023 |
Tong H, Yang T, Liu L, Li C, Sun Y, Jia Q, Qin Y, Chen L, Zhao X, Zhou G, Yan S, Li XJ, Li S. Aberrant splicing of mutant huntingtin in Huntington's disease knock-in pigs. Neurobiology of Disease. 187: 106291. PMID 37716514 DOI: 10.1016/j.nbd.2023.106291 |
0.408 |
|
| 2023 |
Li C, Lin Y, Chen Y, Song X, Zheng X, Li J, He J, Chen X, Huang C, Wang W, Wu J, Wu J, Gao J, Tu Z, Li XJ, et al. A Specific Mini-Intrabody Mediates Lysosome Degradation of Mutant Huntingtin. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2301120. PMID 37688357 DOI: 10.1002/advs.202301120 |
0.425 |
|
| 2023 |
Liu L, Tong H, Sun Y, Chen X, Yang T, Zhou G, Li XJ, Li S. Huntingtin Interacting Proteins and Pathological Implications. International Journal of Molecular Sciences. 24. PMID 37685866 DOI: 10.3390/ijms241713060 |
0.322 |
|
| 2023 |
Pan Y, Tang B, Li XJ, Li S, Liu Q. Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model. Frontiers in Aging Neuroscience. 15: 1237018. PMID 37637962 DOI: 10.3389/fnagi.2023.1237018 |
0.358 |
|
| 2023 |
Yang S, Ma J, Zhang H, Chen L, Li Y, Pan M, Zhu H, Liang J, He D, Li S, Li XJ, Guo X. Mutant HTT does not affect glial development but impairs myelination in the early disease stage. Frontiers in Neuroscience. 17: 1238306. PMID 37539389 DOI: 10.3389/fnins.2023.1238306 |
0.379 |
|
| 2023 |
Bai D, Zhu L, Jia Q, Duan X, Chen L, Wang X, Hou J, Jiang G, Yang S, Li S, Li XJ, Yin P. Loss of TDP-43 promotes somatic CAG repeat expansion in Huntington's disease knock-in mice. Progress in Neurobiology. 227: 102484. PMID 37315918 DOI: 10.1016/j.pneurobio.2023.102484 |
0.339 |
|
| 2023 |
Yan S, Zheng X, Lin Y, Li C, Liu Z, Li J, Tu Z, Zhao Y, Huang C, Chen Y, Li J, Song X, Han B, Wang W, Liang W, ... ... Li XJ, et al. Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington's disease. Nature Biomedical Engineering. PMID 36797418 DOI: 10.1038/s41551-023-01007-3 |
0.31 |
|
| 2022 |
Jia Q, Li S, Li XJ, Yin P. Neuroinflammation in Huntington's disease: From animal models to clinical therapeutics. Frontiers in Immunology. 13: 1088124. PMID 36618375 DOI: 10.3389/fimmu.2022.1088124 |
0.331 |
|
| 2022 |
Zhao X, Sun Y, Wang Z, Chen L, Li S, Li XJ. Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice. Frontiers in Cellular Neuroscience. 16: 1021592. PMID 36439204 DOI: 10.3389/fncel.2022.1021592 |
0.369 |
|
| 2022 |
Chen X, Sun Y, Chen L, Chen XS, Pan M, Zhang Y, Wang Q, Yang W, Yin P, He D, Guo X, Yang S, Zeng Y, Yan S, Li XJ, et al. Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains. Cellular and Molecular Life Sciences : Cmls. 79: 554. PMID 36251080 DOI: 10.1007/s00018-022-04577-8 |
0.426 |
|
| 2021 |
Yin P, Bai D, Deng F, Zhang C, Jia Q, Zhu L, Chen L, Li B, Guo X, Ye J, Tan Z, Wang L, Li S, Li XJ. SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. Autophagy. 1-14. PMID 34936539 DOI: 10.1080/15548627.2021.2013653 |
0.33 |
|
| 2021 |
Yang W, Guo X, Tu Z, Chen X, Han R, Liu Y, Yan S, Wang Q, Wang Z, Zhao X, Zhang Y, Xiong X, Yang H, Yin P, Wan H, ... ... Li XJ, et al. PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein & Cell. PMID 34800266 DOI: 10.1007/s13238-021-00888-x |
0.306 |
|
| 2021 |
Yin P, Bai D, Zhu L, Deng F, Guo X, Li B, Chen L, Li S, Li XJ. Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system. Experimental Neurology. 113833. PMID 34363810 DOI: 10.1016/j.expneurol.2021.113833 |
0.357 |
|
| 2021 |
Jing L, Cheng S, Pan Y, Liu Q, Yang W, Li S, Li XJ. Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice. Molecular Neurobiology. PMID 34250577 DOI: 10.1007/s12035-021-02451-5 |
0.476 |
|
| 2021 |
Bai D, Yin P, Zhang Y, Sun F, Chen L, Lin L, Yan S, Li S, Li XJ. Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models. Human Molecular Genetics. PMID 33949657 DOI: 10.1093/hmg/ddab129 |
0.356 |
|
| 2021 |
Zhang XY, Li J, Li CJ, Lin YQ, Huang CH, Zheng X, Song XC, Tu ZC, Li XJ, Yan S. Differential development and electrophysiological activity in cultured cortical neurons from the mouse and cynomolgus monkey. Neural Regeneration Research. 16: 2446-2452. PMID 33907033 DOI: 10.4103/1673-5374.313056 |
0.303 |
|
| 2020 |
Liu Q, Cheng S, Yang H, Zhu L, Pan Y, Jing L, Tang B, Li S, Li XJ. Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32747555 DOI: 10.1073/Pnas.2002283117 |
0.559 |
|
| 2020 |
Chen X, Xin N, Pan Y, Zhu L, Yin P, Liu Q, Yang W, Xu X, Li S, Li XJ. Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response. Frontiers in Cellular Neuroscience. 14: 125. PMID 32581713 DOI: 10.3389/Fncel.2020.00125 |
0.446 |
|
| 2020 |
Yang H, Yang S, Jing L, Huang L, Chen L, Zhao X, Yang W, Pan Y, Yin P, Qin ZS, Li S, Li XJ. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form. Nature Communications. 11: 2582. PMID 32444599 DOI: 10.1038/S41467-020-16318-1 |
0.546 |
|
| 2020 |
Yin P, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S. Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. Embo Reports. e49783. PMID 32270922 DOI: 10.15252/Embr.201949783 |
0.426 |
|
| 2020 |
Liu Q, Huang S, Yin P, Yang S, Zhang J, Jing L, Cheng S, Tang B, Li XJ, Pan Y, Li S. Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17. Nature Communications. 11: 1101. PMID 32107387 DOI: 10.1038/S41467-020-14931-8 |
0.526 |
|
| 2020 |
Yang S, Yang H, Huang L, Chen L, Qin Z, Li S, Li XJ. Lack of RAN-mediated toxicity in Huntington's disease knock-in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32029588 DOI: 10.1073/Pnas.1919197117 |
0.434 |
|
| 2019 |
Pan Y, Liu Q, Zhang J, Yang Y, Tian Y, Zeng J, Yin P, Mei L, Xiong WC, Li XJ, Li S, Tang B. PRRT2 frameshift mutation reduces its mRNA stability resulting loss of function in paroxysmal kinesigenic dyskinesia. Biochemical and Biophysical Research Communications. PMID 31785815 DOI: 10.1016/J.Bbrc.2019.11.025 |
0.375 |
|
| 2019 |
Liu Q, Pan Y, Li XJ, Li S. Molecular Mechanisms and Therapeutics for SCA17. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31317427 DOI: 10.1007/S13311-019-00762-Z |
0.476 |
|
| 2019 |
Yan S, Li S, Li XJ. Use of large animal models to investigate Huntington's diseases. Cell Regeneration (London, England). 8: 9-11. PMID 31205683 DOI: 10.1016/J.Cr.2019.01.001 |
0.39 |
|
| 2019 |
Ting LL, Lu HT, Yen SF, Ngo TH, Tu FY, Tsai IS, Tsai YH, Chang FY, Li XJ, Li S, Lee CK, Kao SH, Kuo YM, Lin YF. Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer's Disease Model Cells. Molecular Neurobiology. PMID 31062249 DOI: 10.1007/S12035-019-1587-1 |
0.368 |
|
| 2019 |
Yang W, Li S, Li XJ. A CRISPR monkey model unravels a unique function of PINK1 in primate brains. Molecular Neurodegeneration. 14: 17. PMID 31046796 DOI: 10.1186/S13024-019-0321-9 |
0.385 |
|
| 2019 |
Zhu L, Chen L, Yan L, Perkins BD, Li S, Li B, Xu HA, Li XJ. Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish Toxic Gain of Function. Frontiers in Cellular Neuroscience. 13: 81. PMID 30949029 DOI: 10.3389/Fncel.2019.00081 |
0.335 |
|
| 2019 |
Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y, Li S, Li XJ. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathologica. PMID 30810811 DOI: 10.1007/S00401-019-01979-0 |
0.429 |
|
| 2019 |
Yang W, Liu Y, Tu Z, Xiao C, Yan S, Ma X, Guo X, Chen X, Yin P, Yang Z, Yang S, Jiang T, Li S, Qin C, Li XJ. CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Research. PMID 30770867 DOI: 10.1038/S41422-019-0142-Y |
0.334 |
|
| 2019 |
Huang S, Zhu S, Li XJ, Li S. The Expanding Clinical Universe of Polyglutamine Disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858418822993. PMID 30614396 DOI: 10.1177/1073858418822993 |
0.393 |
|
| 2018 |
Li T, Li S, Gao X, Cai Q, Li XJ. Expression and Localization of Huntingtin-Associated Protein 1 (HAP1) in the Human Digestive System. Digestive Diseases and Sciences. PMID 30560333 DOI: 10.1007/S10620-018-5425-5 |
0.46 |
|
| 2018 |
Yang S, Li S, Li XJ. MANF: A New Player in the Control of Energy Homeostasis, and Beyond. Frontiers in Physiology. 9: 1725. PMID 30555354 DOI: 10.3389/Fphys.2018.01725 |
0.369 |
|
| 2018 |
Yang S, Li S, Li XJ. Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity. Cell Reports. 25: 2653-2659.e3. PMID 30517854 DOI: 10.1016/J.Celrep.2018.11.019 |
0.386 |
|
| 2018 |
Tu Z, Zhao H, Li B, Yan S, Wang L, Tang Y, Li Z, Bai D, Li C, Lin Y, Li Y, Liu J, Xu H, Guo X, Jiang YH, ... ... Li XJ, et al. CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms. Human Molecular Genetics. PMID 30329048 DOI: 10.1093/Hmg/Ddy367 |
0.342 |
|
| 2018 |
Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G, ... ... Li XJ, et al. A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. Cell. PMID 29606351 DOI: 10.1016/J.Cell.2018.03.005 |
0.473 |
|
| 2018 |
Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, Tang B, Jin P, Li XJ, Yang S, Li S. Piperine ameliorates SCA17 neuropathology by reducing ER stress. Molecular Neurodegeneration. 13: 4. PMID 29378605 DOI: 10.1186/S13024-018-0236-X |
0.46 |
|
| 2017 |
Yang S, Yang H, Chang R, Yin P, Yang Y, Yang W, Huang S, Gaertig MA, Li S, Li XJ. MANF regulates hypothalamic control of food intake and body weight. Nature Communications. 8: 579. PMID 28924165 DOI: 10.1038/S41467-017-00750-X |
0.316 |
|
| 2017 |
Hong Y, Zhao T, Li XJ, Li S. Mutant huntingtin inhibits αB-crystallin expression and impairs exosome secretion from astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28893927 DOI: 10.1523/Jneurosci.1418-17.2017 |
0.507 |
|
| 2017 |
Zhao T, Hong Y, Yin P, Li S, Li XJ. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28847953 DOI: 10.1073/Pnas.1710549114 |
0.507 |
|
| 2017 |
Yang Y, Yang S, Guo J, Cui Y, Tang B, Li XJ, Li S. Synergistic toxicity of polyglutamine-expanded TBP in glia and neuronal cells: therapeutic implications for SCA17. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28821675 DOI: 10.1523/Jneurosci.0111-17.2017 |
0.512 |
|
| 2017 |
Zhao H, Tu Z, Xu H, Yan S, Yan H, Zheng Y, Yang W, Zheng J, Li Z, Tian R, Lu Y, Guo X, Jiang YH, Li XJ, Zhang YQ. Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate. Cell Research. PMID 28741620 DOI: 10.1038/Cr.2017.95 |
0.313 |
|
| 2017 |
Yang S, Chang R, Yang H, Zhao T, Hong Y, Kong HE, Sun X, Qin Z, Jin P, Li S, Li XJ. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease. The Journal of Clinical Investigation. PMID 28628038 DOI: 10.1172/Jci92087 |
0.492 |
|
| 2017 |
Yan S, Tu Z, Li S, Li XJ. Use of CRISPR/Cas9 to model brain diseases. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28392484 DOI: 10.1016/J.Pnpbp.2017.04.003 |
0.374 |
|
| 2017 |
Xiang J, Yang S, Xin N, Gaertig MA, Reeves RH, Li S, Li XJ. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137862 DOI: 10.1073/Pnas.1614893114 |
0.341 |
|
| 2017 |
Lim Y, Wu LL, Chen S, Sun Y, Vijayaraj SL, Yang M, Bobrovskaya L, Keating D, Li XJ, Zhou XF. HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons. Molecular Neurobiology. PMID 28083816 DOI: 10.1007/S12035-016-0379-0 |
0.385 |
|
| 2016 |
Cui Y, Yang S, Li XJ, Li S. Genetically modified rodent models of SCA17. Journal of Neuroscience Research. PMID 27859490 DOI: 10.1002/Jnr.23984 |
0.41 |
|
| 2016 |
Hong Y, Zhao T, Li XJ, Li S. Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8790-801. PMID 27559163 DOI: 10.1523/Jneurosci.0168-16.2016 |
0.423 |
|
| 2016 |
Zhao T, Hong Y, Li S, Li XJ. Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8317-28. PMID 27511006 DOI: 10.1523/Jneurosci.0806-16.2016 |
0.532 |
|
| 2016 |
Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy. Plos Genetics. 12: e1006083. PMID 27203582 DOI: 10.1371/Journal.Pgen.1006083 |
0.514 |
|
| 2016 |
Yang W, Tu Z, Sun Q, Li XJ. CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases. Frontiers in Molecular Neuroscience. 9: 30. PMID 27199655 DOI: 10.3389/Fnmol.2016.00030 |
0.339 |
|
| 2016 |
Zhao T, Hong Y, Li XJ, Li SH. Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review. Frontiers in Molecular Neuroscience. 9: 27. PMID 27147961 DOI: 10.3389/Fnmol.2016.00027 |
0.529 |
|
| 2016 |
Wang G, Liu X, Gaertig MA, Li S, Li XJ. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951659 DOI: 10.1073/Pnas.1524575113 |
0.45 |
|
| 2015 |
Huang S, Yang S, Guo J, Yan S, Gaertig MA, Li S, Li XJ. Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice. Cell Reports. PMID 26387956 DOI: 10.1016/J.Celrep.2015.08.060 |
0.388 |
|
| 2015 |
Wang G, Yang H, Yan S, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Molecular Neurodegeneration. 10: 42. PMID 26334913 DOI: 10.1186/S13024-015-0036-5 |
0.462 |
|
| 2015 |
Tu Z, Yang W, Yan S, Guo X, Li XJ. CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases. Molecular Neurodegeneration. 10: 35. PMID 26238861 DOI: 10.1186/S13024-015-0031-X |
0.315 |
|
| 2015 |
Jiang W, Wei W, Gaertig MA, Li S, Li XJ. Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model. Plos One. 10: e0134142. PMID 26225560 DOI: 10.1371/Journal.Pone.0134142 |
0.505 |
|
| 2015 |
Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8345-58. PMID 26019347 DOI: 10.1523/Jneurosci.0772-15.2015 |
0.364 |
|
| 2015 |
Chan AW, Jiang J, Chen Y, Li C, Prucha MS, Hu Y, Chi T, Moran S, Rahim T, Li S, Li X, Zola SM, Testa CM, Mao H, Villalba R, et al. Progressive cognitive deficit, motor impairment and striatal pathology in a transgenic Huntington disease monkey model from infancy to adulthood. Plos One. 10: e0122335. PMID 25966278 DOI: 10.1371/Journal.Pone.0122335 |
0.397 |
|
| 2015 |
Chang R, Liu X, Li S, Li XJ. Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy. Drug Design, Development and Therapy. 9: 2179-88. PMID 25931812 DOI: 10.2147/Dddt.S58470 |
0.486 |
|
| 2015 |
Xiang J, Yan S, Li SH, Li XJ. Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice. Plos Genetics. 11: e1005175. PMID 25875952 DOI: 10.1371/Journal.Pgen.1005175 |
0.352 |
|
| 2015 |
Huang B, Wei W, Wang G, Gaertig MA, Feng Y, Wang W, Li XJ, Li S. Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 85: 1212-26. PMID 25789755 DOI: 10.1016/J.Neuron.2015.02.026 |
0.437 |
|
| 2015 |
Jiang W, Li SH, Li X. Therapeutic potential of berberine against neurodegenerative diseases Science China-Life Sciences. 58: 564-569. PMID 25749423 DOI: 10.1007/S11427-015-4829-0 |
0.338 |
|
| 2015 |
Yin P, Tu Z, Yin A, Zhao T, Yan S, Guo X, Chang R, Zhang L, Hong Y, Huang X, Zhou J, Wang Y, Li S, Li XJ. Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Human Molecular Genetics. 24: 1350-62. PMID 25343992 DOI: 10.1093/Hmg/Ddu544 |
0.453 |
|
| 2015 |
Li XJ, Li S. Large Animal Models of Huntington's Disease. Current Topics in Behavioral Neurosciences. 22: 149-60. PMID 24048953 DOI: 10.1007/7854_2013_246 |
0.489 |
|
| 2014 |
Wade BE, Wang CE, Yan S, Bhat K, Huang B, Li S, Li XJ. Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8411-22. PMID 24948797 DOI: 10.1523/Jneurosci.0775-14.2014 |
0.818 |
|
| 2014 |
Bhat KP, Yan S, Wang CE, Li S, Li XJ. Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proceedings of the National Academy of Sciences of the United States of America. 111: 5706-11. PMID 24706802 DOI: 10.1073/Pnas.1402215111 |
0.436 |
|
| 2014 |
Yang S, Huang S, Gaertig MA, Li XJ, Li S. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron. 81: 349-65. PMID 24462098 DOI: 10.1016/J.Neuron.2013.12.002 |
0.493 |
|
| 2014 |
Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S, Li XJ. TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain. Human Molecular Genetics. 23: 2678-93. PMID 24381309 DOI: 10.1093/Hmg/Ddt662 |
0.518 |
|
| 2014 |
Xiang J, Yang H, Zhao T, Sun M, Xu X, Zhou XF, Li SH, Li XJ. Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. The Journal of Clinical Investigation. 124: 85-98. PMID 24355921 DOI: 10.1172/Jci69206 |
0.47 |
|
| 2013 |
Xu Q, Huang S, Song M, Wang CE, Yan S, Liu X, Gaertig MA, Yu SP, Li H, Li S, Li XJ. Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. The Journal of Cell Biology. 202: 1123-38. PMID 24081492 DOI: 10.1083/Jcb.201303146 |
0.454 |
|
| 2013 |
Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S, Li XJ. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8172-84. PMID 23658157 DOI: 10.1523/Jneurosci.0119-13.2013 |
0.399 |
|
| 2012 |
Li XJ, Li S. Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 39: 239-45. PMID 22749010 DOI: 10.1016/J.Jgg.2012.05.002 |
0.46 |
|
| 2012 |
Li XJ, Li W. Beyond mice: genetically modifying larger animals to model human diseases. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 39: 237-8. PMID 22749009 DOI: 10.1016/J.Jgg.2012.05.006 |
0.337 |
|
| 2012 |
Li S, Li XJ. A huntingtin-HAP1-PCM1 pathway in ciliogenesis. Expert Review of Proteomics. 9: 17-9. PMID 22292820 DOI: 10.1586/Epr.11.72 |
0.468 |
|
| 2012 |
Cape A, Chen X, Wang CE, O'Neill A, Lin YF, He J, Xu XS, Yi H, Li H, Li S, Li XJ. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cellular and Molecular Life Sciences : Cmls. 69: 1305-17. PMID 21544547 DOI: 10.1007/S00018-011-0692-8 |
0.774 |
|
| 2012 |
Li X, Li S. Neuropathology of transgenic HD animal models Molecular Neurodegeneration. 7: 1-1. DOI: 10.1186/1750-1326-7-S1-L17 |
0.416 |
|
| 2011 |
Mandal M, Wei J, Zhong P, Cheng J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z. Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. The Journal of Biological Chemistry. 286: 33719-28. PMID 21832090 DOI: 10.1074/Jbc.M111.236521 |
0.448 |
|
| 2011 |
Huang S, Ling JJ, Yang S, Li XJ, Li S. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain : a Journal of Neurology. 134: 1943-58. PMID 21705419 DOI: 10.1093/Brain/Awr146 |
0.549 |
|
| 2011 |
Yang M, Lim Y, Li X, Zhong J, Zhou X. Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing Journal of Biological Chemistry. 286: 16272-16284. PMID 21357693 DOI: 10.1074/Jbc.M110.195347 |
0.452 |
|
| 2011 |
Havel LS, Wang CE, Wade B, Huang B, Li S, Li XJ. Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Human Molecular Genetics. 20: 1424-37. PMID 21245084 DOI: 10.1093/Hmg/Ddr023 |
0.819 |
|
| 2011 |
Li XJ, Li S. Proteasomal dysfunction in aging and Huntington disease. Neurobiology of Disease. 43: 4-8. PMID 21145396 DOI: 10.1016/J.Nbd.2010.11.018 |
0.492 |
|
| 2010 |
Wang CE, Li S, Li XJ. Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice. Molecular Brain. 3: 33. PMID 21044321 DOI: 10.1186/1756-6606-3-33 |
0.423 |
|
| 2010 |
Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 107: 19126-31. PMID 20956301 DOI: 10.1073/Pnas.1013032107 |
0.794 |
|
| 2010 |
Yang D, Wang CE, Zhao B, Li W, Ouyang Z, Liu Z, Yang H, Fan P, O'Neill A, Gu W, Yi H, Li S, Lai L, Li XJ. Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Human Molecular Genetics. 19: 3983-94. PMID 20660116 DOI: 10.1093/hmg/ddq313 |
0.446 |
|
| 2010 |
Li XJ, Li H, Li S. Clearance of mutant huntingtin. Autophagy. 6: 663-4. PMID 20519964 DOI: 10.4161/Auto.6.5.12336 |
0.505 |
|
| 2010 |
Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Human Molecular Genetics. 19: 2445-55. PMID 20354076 DOI: 10.1093/Hmg/Ddq127 |
0.519 |
|
| 2010 |
Lin YF, Xu X, Cape A, Li S, Li XJ. Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. The Journal of Biological Chemistry. 285: 15941-9. PMID 20304926 DOI: 10.1074/Jbc.M110.107318 |
0.82 |
|
| 2010 |
Bradford JW, Li S, Li XJ. Polyglutamine toxicity in non-neuronal cells. Cell Research. 20: 400-7. PMID 20231860 DOI: 10.1038/cr.2010.32 |
0.41 |
|
| 2010 |
Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. The Journal of Biological Chemistry. 285: 10653-61. PMID 20145253 DOI: 10.1074/jbc.M109.083287 |
0.691 |
|
| 2010 |
Wu LL, Fan Y, Li S, Li XJ, Zhou XF. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. The Journal of Biological Chemistry. 285: 5614-23. PMID 19996106 DOI: 10.1074/Jbc.M109.073197 |
0.357 |
|
| 2010 |
Li XJ, Orr AL, Li S. Impaired mitochondrial trafficking in Huntington's disease. Biochimica Et Biophysica Acta. 1802: 62-5. PMID 19591925 DOI: 10.1016/J.Bbadis.2009.06.008 |
0.725 |
|
| 2009 |
Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proceedings of the National Academy of Sciences of the United States of America. 106: 22480-5. PMID 20018729 DOI: 10.1073/pnas.0911503106 |
0.705 |
|
| 2009 |
Friedman MJ, Li S, Li XJ. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. The Journal of Biological Chemistry. 284: 27944-51. PMID 19656944 DOI: 10.1074/Jbc.M109.037937 |
0.801 |
|
| 2009 |
Shah AG, Friedman MJ, Huang S, Roberts M, Li XJ, Li S. Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Human Molecular Genetics. 18: 4141-52. PMID 19643914 DOI: 10.1093/Hmg/Ddp363 |
0.833 |
|
| 2009 |
Havel LS, Li S, Li XJ. Nuclear accumulation of polyglutamine disease proteins and neuropathology. Molecular Brain. 2: 21. PMID 19575804 DOI: 10.1186/1756-6606-2-21 |
0.8 |
|
| 2009 |
Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nature Neuroscience. 12: 872-8. PMID 19525944 DOI: 10.1038/Nn.2341 |
0.673 |
|
| 2008 |
Tydlacka S, Wang CE, Wang X, Li S, Li XJ. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13285-95. PMID 19052220 DOI: 10.1523/Jneurosci.4393-08.2008 |
0.815 |
|
| 2008 |
Zhou LL, Zhao Y, Ringrose A, DeGeer D, Kennah E, Lin AE, Sheng G, Li XJ, Turhan A, Jiang X. AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells. The Journal of Experimental Medicine. 205: 2657-71. PMID 18936234 DOI: 10.1084/Jem.20072316 |
0.307 |
|
| 2008 |
Li X, Li H, Li XJ. Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases. Brain Research Reviews. 59: 245-52. PMID 18773920 DOI: 10.1016/J.Brainresrev.2008.08.003 |
0.491 |
|
| 2008 |
Sheng G, Xu X, Lin YF, Wang CE, Rong J, Cheng D, Peng J, Jiang X, Li SH, Li XJ. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. The Journal of Clinical Investigation. 118: 2785-95. PMID 18636121 DOI: 10.1172/Jci35339 |
0.769 |
|
| 2008 |
Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human Molecular Genetics. 17: 2738-51. PMID 18558632 DOI: 10.1093/Hmg/Ddn175 |
0.812 |
|
| 2008 |
Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6182-95. PMID 18550760 DOI: 10.1523/Jneurosci.0857-08.2008 |
0.49 |
|
| 2008 |
Wang CE, Zhou H, McGuire JR, Cerullo V, Lee B, Li SH, Li XJ. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. The Journal of Cell Biology. 181: 803-16. PMID 18504298 DOI: 10.1083/Jcb.200710158 |
0.505 |
|
| 2008 |
Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li XJ. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. The Journal of Biological Chemistry. 283: 16027-36. PMID 18400759 DOI: 10.1074/Jbc.M710606200 |
0.753 |
|
| 2008 |
Liu Z, Jang SW, Liu X, Cheng D, Peng J, Yepes M, Li XJ, Matthews S, Watts C, Asano M, Hara-Nishimura I, Luo HR, Ye K. Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase. Molecular Cell. 29: 665-78. PMID 18374643 DOI: 10.1016/J.Molcel.2008.02.017 |
0.38 |
|
| 2008 |
Wang J, Wang CE, Orr A, Tydlacka S, Li SH, Li XJ. Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. The Journal of Cell Biology. 180: 1177-89. PMID 18362179 DOI: 10.1083/Jcb.200709080 |
0.794 |
|
| 2008 |
Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2783-92. PMID 18337408 DOI: 10.1523/Jneurosci.0106-08.2008 |
0.825 |
|
| 2008 |
Friedman MJ, Wang CE, Li XJ, Li S. Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity. The Journal of Biological Chemistry. 283: 8283-90. PMID 18218637 DOI: 10.1074/Jbc.M709674200 |
0.784 |
|
| 2008 |
Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O. Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Human Molecular Genetics. 17: 1137-46. PMID 18192679 DOI: 10.1093/Hmg/Ddn003 |
0.774 |
|
| 2007 |
Friedman MJ, Shah AG, Fang ZH, Ward EG, Warren ST, Li S, Li XJ. Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nature Neuroscience. 10: 1519-28. PMID 17994014 DOI: 10.1038/Nn2011 |
0.814 |
|
| 2007 |
Li XJ, Friedman M, Li S. Interacting proteins as genetic modifiers of Huntington disease. Trends in Genetics : Tig. 23: 531-3. PMID 17961788 DOI: 10.1016/J.Tig.2007.07.007 |
0.801 |
|
| 2007 |
Rong J, Li SH, Li XJ. Regulation of intracellular HAP1 trafficking. Journal of Neuroscience Research. 85: 3025-9. PMID 17474105 DOI: 10.1002/Jnr.21326 |
0.795 |
|
| 2007 |
Gu X, André VM, Cepeda C, Li SH, Li XJ, Levine MS, Yang XW. Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Molecular Neurodegeneration. 2: 8. PMID 17470275 DOI: 10.1186/1750-1326-2-8 |
0.47 |
|
| 2007 |
Rong J, Li S, Sheng G, Wu M, Coblitz B, Li M, Fu H, Li XJ. 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. The Journal of Biological Chemistry. 282: 4748-56. PMID 17166838 DOI: 10.1074/Jbc.M609057200 |
0.758 |
|
| 2007 |
Zhang X, Winkles JA, Gongora MC, Polavarapu R, Michaelson JS, Hahm K, Burkly L, Friedman M, Li XJ, Yepes M. TWEAK-Fn14 pathway inhibition protects the integrity of the neurovascular unit during cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 534-44. PMID 16835630 DOI: 10.1038/Sj.Jcbfm.9600368 |
0.761 |
|
| 2007 |
Zhao Y, Zhou L, Ringrose A, Lin AE, Kennah E, Sheng G, Li X, Turhan A, Jiang X. Interaction of a Novel Signaling Protein (AHI-1) with BCR-ABL Modulates BCR-ABL Transforming Activity and Imatinib Response of Chronic Myeloid Leukemia Progenitor Cells. Blood. 110: 467-467. DOI: 10.1182/Blood.V110.11.467.467 |
0.36 |
|
| 2007 |
Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. Erratum: The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-Β production (Nature (2006) 440, (528-534)) Nature. 446. DOI: 10.1038/Nature05606 |
0.304 |
|
| 2006 |
Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, ... ... Li XJ, et al. Recent advances in basic neurosciences and brain disease: from synapses to behavior. Molecular Pain. 2: 38. PMID 17196111 DOI: 10.1186/1744-8069-2-38 |
0.356 |
|
| 2006 |
Li S, Li XJ. Multiple pathways contribute to the pathogenesis of Huntington disease. Molecular Neurodegeneration. 1: 19. PMID 17173700 DOI: 10.1186/1750-1326-1-19 |
0.516 |
|
| 2006 |
Cornett J, Smith L, Friedman M, Shin JY, Li XJ, Li SH. Context-dependent dysregulation of transcription by mutant huntingtin. The Journal of Biological Chemistry. 281: 36198-204. PMID 17012230 DOI: 10.1074/Jbc.M607839200 |
0.812 |
|
| 2006 |
Rong J, McGuire JR, Fang ZH, Sheng G, Shin JY, Li SH, Li XJ. Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6019-30. PMID 16738245 DOI: 10.1523/Jneurosci.1251-06.2006 |
0.813 |
|
| 2006 |
Sheng G, Chang GQ, Lin JY, Yu ZX, Fang ZH, Rong J, Lipton SA, Li SH, Tong G, Leibowitz SF, Li XJ. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature Medicine. 12: 526-33. PMID 16604089 DOI: 10.1038/Nm1382 |
0.733 |
|
| 2006 |
Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP. The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production. Nature. 440: 528-34. PMID 16554819 DOI: 10.1038/Nature04543 |
0.391 |
|
| 2006 |
Bae BI, Hara MR, Cascio MB, Wellington CL, Hayden MR, Ross CA, Ha HC, Li XJ, Snyder SH, Sawa A. Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proceedings of the National Academy of Sciences of the United States of America. 103: 3405-9. PMID 16492755 DOI: 10.1073/Pnas.0511316103 |
0.326 |
|
| 2006 |
McGuire JR, Rong J, Li SH, Li XJ. Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. The Journal of Biological Chemistry. 281: 3552-9. PMID 16339760 DOI: 10.1074/Jbc.M509806200 |
0.787 |
|
| 2006 |
Shin J, Fang Z, Yu Z, Wang C, Li S, Li X. Correction: Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity Journal of Cell Biology. 172: 953-953. DOI: 10.1083/Jcb.20050807220060228C |
0.684 |
|
| 2005 |
Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. The Journal of Cell Biology. 171: 1001-12. PMID 16365166 DOI: 10.1083/Jcb.200508072 |
0.708 |
|
| 2005 |
Benn CL, Landles C, Li H, Strand AD, Woodman B, Sathasivam K, Li SH, Ghazi-Noori S, Hockly E, Faruque SM, Cha JH, Sharpe PT, Olson JM, Li XJ, Bates GP. Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Human Molecular Genetics. 14: 3065-78. PMID 16183657 DOI: 10.1093/Hmg/Ddi340 |
0.412 |
|
| 2005 |
Liao M, Shen J, Zhang Y, Li SH, Li XJ, Li H. Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1517-24. PMID 16087704 DOI: 10.1369/Jhc.5A6662.2005 |
0.359 |
|
| 2005 |
Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron. 46: 433-44. PMID 15882643 DOI: 10.1016/J.Neuron.2005.03.025 |
0.491 |
|
| 2005 |
Cornett J, Cao F, Wang CE, Ross CA, Bates GP, Li SH, Li XJ. Polyglutamine expansion of huntingtin impairs its nuclear export. Nature Genetics. 37: 198-204. PMID 15654337 DOI: 10.1038/Ng1503 |
0.359 |
|
| 2005 |
Li XJ, Li SH. HAP1 and intracellular trafficking. Trends in Pharmacological Sciences. 26: 1-3. PMID 15629196 DOI: 10.1016/J.Tips.2004.11.001 |
0.421 |
|
| 2005 |
Cornett J, Friedman M, Li SH, Li XJ. Transcriptional dysregulation: A therapeutic target for polyglutamine diseases Current Medicinal Chemistry - Central Nervous System Agents. 5: 119-127. DOI: 10.2174/1568015054022399 |
0.764 |
|
| 2005 |
McGuire J, Li S, Li X. Polyglutamine Protein Trafficking and Neurodegeneration Current Genomics. 6: 189-194. DOI: 10.2174/1389202053971938 |
0.371 |
|
| 2005 |
Ringrose A, Zhou Y, Pang E, Lin AE, Li X, Li I, Weng A, Jiang X. Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome. Blood. 106: 2605-2605. DOI: 10.1182/Blood.V106.11.2605.2605 |
0.314 |
|
| 2004 |
Li SH, Li XJ. Huntingtin and its role in neuronal degeneration. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10: 467-75. PMID 15359012 DOI: 10.1177/1073858404266777 |
0.461 |
|
| 2004 |
Li SH, Li XJ. Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends in Genetics : Tig. 20: 146-54. PMID 15036808 DOI: 10.1016/J.Tig.2004.01.008 |
0.431 |
|
| 2003 |
Zhou H, Cao F, Wang Z, Yu ZX, Nguyen HP, Evans J, Li SH, Li XJ. Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. The Journal of Cell Biology. 163: 109-18. PMID 14557250 DOI: 10.1083/Jcb.200306038 |
0.489 |
|
| 2003 |
Li H, Wyman T, Yu ZX, Li SH, Li XJ. Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Human Molecular Genetics. 12: 2021-30. PMID 12913073 DOI: 10.1093/Hmg/Ddg218 |
0.401 |
|
| 2003 |
Liou YC, Sun A, Ryo A, Zhou XZ, Yu ZX, Huang HK, Uchida T, Bronson R, Bing G, Li X, Hunter T, Lu KP. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. Nature. 424: 556-61. PMID 12891359 DOI: 10.1038/Nature01832 |
0.457 |
|
| 2003 |
Li SH, Yu ZX, Li CL, Nguyen HP, Zhou YX, Deng C, Li XJ. Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6956-64. PMID 12890790 DOI: 10.1523/JNEUROSCI.23-17-06956.2003 |
0.41 |
|
| 2003 |
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Human Molecular Genetics. 12: 1555-67. PMID 12812983 DOI: 10.1093/Hmg/Ddg169 |
0.454 |
|
| 2003 |
Yu ZX, Li SH, Evans J, Pillarisetti A, Li H, Li XJ. Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2193-202. PMID 12657678 DOI: 10.1523/Jneurosci.23-06-02193.2003 |
0.54 |
|
| 2003 |
von Hörsten S, Schmitt I, Nguyen HP, Holzmann C, Schmidt T, Walther T, Bader M, Pabst R, Kobbe P, Krotova J, Stiller D, Kask A, Vaarmann A, Rathke-Hartlieb S, Schulz JB, ... ... Li XJ, et al. Transgenic rat model of Huntington's disease. Human Molecular Genetics. 12: 617-24. PMID 12620967 DOI: 10.1093/Hmg/Ddg075 |
0.414 |
|
| 2003 |
Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP. Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 2911-6. PMID 12589027 DOI: 10.1073/Pnas.0536856100 |
0.387 |
|
| 2002 |
Menalled LB, Sison JD, Wu Y, Olivieri M, Li XJ, Li H, Zeitlin S, Chesselet MF. Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8266-76. PMID 12223581 DOI: 10.1523/Jneurosci.22-18-08266.2002 |
0.448 |
|
| 2002 |
Yu ZX, Li SH, Nguyen HP, Li XJ. Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice. Human Molecular Genetics. 11: 905-14. PMID 11971872 DOI: 10.1093/Hmg/11.8.905 |
0.455 |
|
| 2002 |
Chuang JZ, Zhou H, Zhu M, Li SH, Li XJ, Sung CH. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. The Journal of Biological Chemistry. 277: 19831-8. PMID 11896048 DOI: 10.1074/Jbc.M109613200 |
0.405 |
|
| 2002 |
Li SH, Cheng AL, Zhou H, Lam S, Rao M, Li H, Li XJ. Interaction of Huntington disease protein with transcriptional activator Sp1. Molecular and Cellular Biology. 22: 1277-87. PMID 11839795 DOI: 10.1128/Mcb.22.5.1277-1287.2002 |
0.453 |
|
| 2001 |
Zhou H, Li S, Li X. Chaperone suppression of cellular toxicity of huntingtin is independent of polyglutamine aggregation. Journal of Biological Chemistry. 276: 48417-48424. PMID 11606565 DOI: 10.1074/Jbc.M104140200 |
0.414 |
|
| 2001 |
Cao F, Levine JJ, Li SH, Li XJ. Nuclear aggregation of huntingtin is not prevented by deletion of chaperone Hsp104. Biochimica Et Biophysica Acta. 1537: 158-66. PMID 11566259 DOI: 10.1016/S0925-4439(01)00068-0 |
0.405 |
|
| 2001 |
Schilling G, Jinnah HA, Gonzales V, Coonfield ML, Kim Y, Wood JD, Price DL, Li XJ, Jenkins N, Copeland N, Moran T, Ross CA, Borchelt DR. Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA. Neurobiology of Disease. 8: 405-18. PMID 11442350 DOI: 10.1006/Nbdi.2001.0385 |
0.509 |
|
| 2001 |
Li H, Li S, Yu Z, Shelbourne P, Li X. Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease Mice The Journal of Neuroscience. 21: 8473-8481. DOI: 10.1523/Jneurosci.21-21-08473.2001 |
0.454 |
|
| 2000 |
Freeman TB, Cicchetti F, Hauser RA, Deacon TW, Li XJ, Hersch SM, Nauert GM, Sanberg PR, Kordower JH, Saporta S, Isacson O. Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology. Proceedings of the National Academy of Sciences of the United States of America. 97: 13877-82. PMID 11106399 DOI: 10.1073/Pnas.97.25.13877 |
0.406 |
|
| 2000 |
Li S, Lam S, Cheng AL, Li X. Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis Human Molecular Genetics. 9: 2859-2867. PMID 11092762 DOI: 10.1093/Hmg/9.19.2859 |
0.393 |
|
| 2000 |
Li XJ. The early cellular pathology of Huntington's disease. Molecular Neurobiology. 20: 111-24. PMID 10966117 DOI: 10.1007/Bf02742437 |
0.54 |
|
| 2000 |
Li H, Li SH, Johnston H, Shelbourne PF, Li XJ. Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity. Nature Genetics. 25: 385-9. PMID 10932179 DOI: 10.1038/78054 |
0.512 |
|
| 2000 |
Li SH, Li H, Torre ER, Li XJ. Expression of huntingtin-associated protein-1 in neuronal cells implicates a role in neuritic growth. Molecular and Cellular Neurosciences. 16: 168-83. PMID 10924259 DOI: 10.1006/Mcne.2000.0858 |
0.479 |
|
| 1999 |
Kuemmerle S, Gutekunst CA, Klein AM, Li XJ, Li SH, Beal MF, Hersch SM, Ferrante RJ. Huntington aggregates may not predict neuronal death in Huntington's disease. Annals of Neurology. 46: 842-9. PMID 10589536 DOI: 10.1002/1531-8249(199912)46:6<842::Aid-Ana6>3.0.Co;2-O |
0.462 |
|
| 1999 |
Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, Jamot L, Li XJ, Stevens ME, Rosemond E, Roder JC, et al. A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron. 23: 181-92. PMID 10402204 DOI: 10.1016/S0896-6273(00)80764-3 |
0.531 |
|
| 1999 |
Li H, Li SH, Cheng AL, Mangiarini L, Bates GP, Li XJ. Ultrastructural localization and progressive formation of neuropil aggregates in Huntington's disease transgenic mice. Human Molecular Genetics. 8: 1227-36. PMID 10369868 DOI: 10.1093/Hmg/8.7.1227 |
0.445 |
|
| 1999 |
Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, Yuan J, Penney JB, Young AB, Cha JH, Friedlander RM. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature. 399: 263-7. PMID 10353249 DOI: 10.1038/20446 |
0.47 |
|
| 1999 |
Gutekunst CA, Li SH, Yi H, Mulroy JS, Kuemmerle S, Jones R, Rye D, Ferrante RJ, Hersch SM, Li XJ. Nuclear and neuropil aggregates in Huntington's disease: relationship to neuropathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2522-34. PMID 10087066 DOI: 10.1523/Jneurosci.19-07-02522.1999 |
0.456 |
|
| 1999 |
Li S, Cheng AL, Li H, Li X. Cellular Defects and Altered Gene Expression in PC12 Cells Stably Expressing Mutant Huntingtin The Journal of Neuroscience. 19: 5159-5172. DOI: 10.1523/Jneurosci.19-13-05159.1999 |
0.398 |
|
| 1998 |
Li SH, Gutekunst CA, Hersch SM, Li XJ. Association of HAP1 isoforms with a unique cytoplasmic structure. Journal of Neurochemistry. 71: 2178-85. PMID 9798945 DOI: 10.1046/J.1471-4159.1998.71052178.X |
0.38 |
|
| 1998 |
Gutekunst CA, Li SH, Yi H, Ferrante RJ, Li XJ, Hersch SM. The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7674-86. PMID 9742138 DOI: 10.1523/Jneurosci.18-19-07674.1998 |
0.428 |
|
| 1998 |
Li SH, Hosseini SH, Gutekunst CA, Hersch SM, Ferrante RJ, Li XJ. A human HAP1 homologue. Cloning, expression, and interaction with huntingtin. The Journal of Biological Chemistry. 273: 19220-7. PMID 9668110 DOI: 10.1074/Jbc.273.30.19220 |
0.42 |
|
| 1998 |
Li S, Li X. Aggregation of N-Terminal Huntingtin is Dependent on the Length of Its Glutamine Repeats Human Molecular Genetics. 7: 777-782. PMID 9536080 DOI: 10.1093/Hmg/7.5.777 |
0.467 |
|
| 1998 |
Li SH, Gutekunst CA, Hersch SM, Li XJ. Interaction of huntingtin-associated protein with dynactin P150Glued. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1261-9. PMID 9454836 DOI: 10.1523/Jneurosci.18-04-01261.1998 |
0.419 |
|
| 1998 |
Reddy TR, Li X, Jones Y, Ellisman MH, Ching GY, Liem RK, Wong-Staal F. Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 702-7. PMID 9435256 DOI: 10.1073/Pnas.95.2.702 |
0.307 |
|
| 1995 |
Sharp AH, Loev SJ, Schilling G, Li SH, Li XJ, Bao J, Wagster MV, Kotzuk JA, Steiner JP, Lo A. Widespread expression of Huntington's disease gene (IT15) protein product. Neuron. 14: 1065-74. PMID 7748554 DOI: 10.1016/0896-6273(95)90345-3 |
0.379 |
|
| 1995 |
Li XJ, Snyder SH. Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds. The Journal of Biological Chemistry. 270: 17674-9. PMID 7629065 DOI: 10.1074/Jbc.270.30.17674 |
0.346 |
|
| 1995 |
Li XJ, Li SH, Sharp AH, Nucifora FC, Schilling G, Lanahan A, Worley P, Snyder SH, Ross CA. A huntingtin-associated protein enriched in brain with implications for pathology. Nature. 378: 398-402. PMID 7477378 DOI: 10.1038/378398A0 |
0.367 |
|
| Show low-probability matches. |