Xiao-Jiang Li - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
Molecular Biology, Neuroscience Biology, Genetics

163 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Yin P, Bai D, Deng F, Zhang C, Jia Q, Zhu L, Chen L, Li B, Guo X, Ye J, Tan Z, Wang L, Li S, Li XJ. SQSTM1-mediated clearance of cytoplasmic mutant TARDBP/TDP-43 in the monkey brain. Autophagy. 1-14. PMID 34936539 DOI: 10.1080/15548627.2021.2013653  0.33
2021 Yang W, Guo X, Tu Z, Chen X, Han R, Liu Y, Yan S, Wang Q, Wang Z, Zhao X, Zhang Y, Xiong X, Yang H, Yin P, Wan H, ... ... Li XJ, et al. PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis. Protein & Cell. PMID 34800266 DOI: 10.1007/s13238-021-00888-x  0.304
2021 Yin P, Bai D, Zhu L, Deng F, Guo X, Li B, Chen L, Li S, Li XJ. Cytoplasmic TDP-43 impairs the activity of the ubiquitin-proteasome system. Experimental Neurology. 113833. PMID 34363810 DOI: 10.1016/j.expneurol.2021.113833  0.358
2021 Jing L, Cheng S, Pan Y, Liu Q, Yang W, Li S, Li XJ. Accumulation of Endogenous Mutant Huntingtin in Astrocytes Exacerbates Neuropathology of Huntington Disease in Mice. Molecular Neurobiology. PMID 34250577 DOI: 10.1007/s12035-021-02451-5  0.475
2021 Bai D, Yin P, Zhang Y, Sun F, Chen L, Lin L, Yan S, Li S, Li XJ. Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models. Human Molecular Genetics. PMID 33949657 DOI: 10.1093/hmg/ddab129  0.354
2020 Liu Q, Cheng S, Yang H, Zhu L, Pan Y, Jing L, Tang B, Li S, Li XJ. Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32747555 DOI: 10.1073/Pnas.2002283117  0.558
2020 Chen X, Xin N, Pan Y, Zhu L, Yin P, Liu Q, Yang W, Xu X, Li S, Li XJ. Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response. Frontiers in Cellular Neuroscience. 14: 125. PMID 32581713 DOI: 10.3389/Fncel.2020.00125  0.446
2020 Yang H, Yang S, Jing L, Huang L, Chen L, Zhao X, Yang W, Pan Y, Yin P, Qin ZS, Li S, Li XJ. Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form. Nature Communications. 11: 2582. PMID 32444599 DOI: 10.1038/S41467-020-16318-1  0.545
2020 Yin P, Liu Q, Pan Y, Yang W, Yang S, Wei W, Chen X, Hong Y, Bai D, Li XJ, Li S. Phosphorylation of myelin regulatory factor by PRKG2 mediates demyelination in Huntington's disease. Embo Reports. e49783. PMID 32270922 DOI: 10.15252/Embr.201949783  0.427
2020 Liu Q, Huang S, Yin P, Yang S, Zhang J, Jing L, Cheng S, Tang B, Li XJ, Pan Y, Li S. Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17. Nature Communications. 11: 1101. PMID 32107387 DOI: 10.1038/S41467-020-14931-8  0.527
2020 Yang S, Yang H, Huang L, Chen L, Qin Z, Li S, Li XJ. Lack of RAN-mediated toxicity in Huntington's disease knock-in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32029588 DOI: 10.1073/Pnas.1919197117  0.434
2019 Pan Y, Liu Q, Zhang J, Yang Y, Tian Y, Zeng J, Yin P, Mei L, Xiong WC, Li XJ, Li S, Tang B. PRRT2 frameshift mutation reduces its mRNA stability resulting loss of function in paroxysmal kinesigenic dyskinesia. Biochemical and Biophysical Research Communications. PMID 31785815 DOI: 10.1016/J.Bbrc.2019.11.025  0.374
2019 Liu Q, Pan Y, Li XJ, Li S. Molecular Mechanisms and Therapeutics for SCA17. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31317427 DOI: 10.1007/S13311-019-00762-Z  0.479
2019 Yan S, Li S, Li XJ. Use of large animal models to investigate Huntington's diseases. Cell Regeneration (London, England). 8: 9-11. PMID 31205683 DOI: 10.1016/J.Cr.2019.01.001  0.389
2019 Ting LL, Lu HT, Yen SF, Ngo TH, Tu FY, Tsai IS, Tsai YH, Chang FY, Li XJ, Li S, Lee CK, Kao SH, Kuo YM, Lin YF. Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer's Disease Model Cells. Molecular Neurobiology. PMID 31062249 DOI: 10.1007/S12035-019-1587-1  0.367
2019 Yang W, Li S, Li XJ. A CRISPR monkey model unravels a unique function of PINK1 in primate brains. Molecular Neurodegeneration. 14: 17. PMID 31046796 DOI: 10.1186/S13024-019-0321-9  0.383
2019 Zhu L, Chen L, Yan L, Perkins BD, Li S, Li B, Xu HA, Li XJ. Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish Toxic Gain of Function. Frontiers in Cellular Neuroscience. 13: 81. PMID 30949029 DOI: 10.3389/Fncel.2019.00081  0.335
2019 Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y, Li S, Li XJ. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathologica. PMID 30810811 DOI: 10.1007/S00401-019-01979-0  0.429
2019 Yang W, Liu Y, Tu Z, Xiao C, Yan S, Ma X, Guo X, Chen X, Yin P, Yang Z, Yang S, Jiang T, Li S, Qin C, Li XJ. CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Research. PMID 30770867 DOI: 10.1038/S41422-019-0142-Y  0.334
2019 Huang S, Zhu S, Li XJ, Li S. The Expanding Clinical Universe of Polyglutamine Disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858418822993. PMID 30614396 DOI: 10.1177/1073858418822993  0.393
2018 Li T, Li S, Gao X, Cai Q, Li XJ. Expression and Localization of Huntingtin-Associated Protein 1 (HAP1) in the Human Digestive System. Digestive Diseases and Sciences. PMID 30560333 DOI: 10.1007/S10620-018-5425-5  0.458
2018 Yang S, Li S, Li XJ. MANF: A New Player in the Control of Energy Homeostasis, and Beyond. Frontiers in Physiology. 9: 1725. PMID 30555354 DOI: 10.3389/Fphys.2018.01725  0.369
2018 Yang S, Li S, Li XJ. Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity. Cell Reports. 25: 2653-2659.e3. PMID 30517854 DOI: 10.1016/J.Celrep.2018.11.019  0.385
2018 Tu Z, Zhao H, Li B, Yan S, Wang L, Tang Y, Li Z, Bai D, Li C, Lin Y, Li Y, Liu J, Xu H, Guo X, Jiang YH, ... ... Li XJ, et al. CRISPR/Cas9-mediated disruption of SHANK3 in monkey leads to drug-treatable autism-like symptoms. Human Molecular Genetics. PMID 30329048 DOI: 10.1093/Hmg/Ddy367  0.341
2018 Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G, ... ... Li XJ, et al. A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. Cell. PMID 29606351 DOI: 10.1016/J.Cell.2018.03.005  0.472
2018 Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, Tang B, Jin P, Li XJ, Yang S, Li S. Piperine ameliorates SCA17 neuropathology by reducing ER stress. Molecular Neurodegeneration. 13: 4. PMID 29378605 DOI: 10.1186/S13024-018-0236-X  0.46
2017 Yang S, Yang H, Chang R, Yin P, Yang Y, Yang W, Huang S, Gaertig MA, Li S, Li XJ. MANF regulates hypothalamic control of food intake and body weight. Nature Communications. 8: 579. PMID 28924165 DOI: 10.1038/S41467-017-00750-X  0.316
2017 Hong Y, Zhao T, Li XJ, Li S. Mutant huntingtin inhibits αB-crystallin expression and impairs exosome secretion from astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28893927 DOI: 10.1523/Jneurosci.1418-17.2017  0.506
2017 Zhao T, Hong Y, Yin P, Li S, Li XJ. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28847953 DOI: 10.1073/Pnas.1710549114  0.506
2017 Yang Y, Yang S, Guo J, Cui Y, Tang B, Li XJ, Li S. Synergistic toxicity of polyglutamine-expanded TBP in glia and neuronal cells: therapeutic implications for SCA17. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28821675 DOI: 10.1523/Jneurosci.0111-17.2017  0.51
2017 Zhao H, Tu Z, Xu H, Yan S, Yan H, Zheng Y, Yang W, Zheng J, Li Z, Tian R, Lu Y, Guo X, Jiang YH, Li XJ, Zhang YQ. Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate. Cell Research. PMID 28741620 DOI: 10.1038/Cr.2017.95  0.312
2017 Yang S, Chang R, Yang H, Zhao T, Hong Y, Kong HE, Sun X, Qin Z, Jin P, Li S, Li XJ. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease. The Journal of Clinical Investigation. PMID 28628038 DOI: 10.1172/Jci92087  0.491
2017 Yan S, Tu Z, Li S, Li XJ. Use of CRISPR/Cas9 to model brain diseases. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28392484 DOI: 10.1016/J.Pnpbp.2017.04.003  0.373
2017 Xiang J, Yang S, Xin N, Gaertig MA, Reeves RH, Li S, Li XJ. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137862 DOI: 10.1073/Pnas.1614893114  0.341
2017 Lim Y, Wu LL, Chen S, Sun Y, Vijayaraj SL, Yang M, Bobrovskaya L, Keating D, Li XJ, Zhou XF. HAP1 Is Required for Endocytosis and Signalling of BDNF and Its Receptors in Neurons. Molecular Neurobiology. PMID 28083816 DOI: 10.1007/S12035-016-0379-0  0.384
2016 Cui Y, Yang S, Li XJ, Li S. Genetically modified rodent models of SCA17. Journal of Neuroscience Research. PMID 27859490 DOI: 10.1002/Jnr.23984  0.41
2016 Hong Y, Zhao T, Li XJ, Li S. Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8790-801. PMID 27559163 DOI: 10.1523/Jneurosci.0168-16.2016  0.421
2016 Zhao T, Hong Y, Li S, Li XJ. Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8317-28. PMID 27511006 DOI: 10.1523/Jneurosci.0806-16.2016  0.53
2016 Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy. Plos Genetics. 12: e1006083. PMID 27203582 DOI: 10.1371/Journal.Pgen.1006083  0.512
2016 Yang W, Tu Z, Sun Q, Li XJ. CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases. Frontiers in Molecular Neuroscience. 9: 30. PMID 27199655 DOI: 10.3389/Fnmol.2016.00030  0.339
2016 Zhao T, Hong Y, Li XJ, Li SH. Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review. Frontiers in Molecular Neuroscience. 9: 27. PMID 27147961 DOI: 10.3389/Fnmol.2016.00027  0.527
2016 Wang G, Liu X, Gaertig MA, Li S, Li XJ. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951659 DOI: 10.1073/Pnas.1524575113  0.448
2015 Huang S, Yang S, Guo J, Yan S, Gaertig MA, Li S, Li XJ. Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice. Cell Reports. PMID 26387956 DOI: 10.1016/J.Celrep.2015.08.060  0.389
2015 Wang G, Yang H, Yan S, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Molecular Neurodegeneration. 10: 42. PMID 26334913 DOI: 10.1186/S13024-015-0036-5  0.461
2015 Tu Z, Yang W, Yan S, Guo X, Li XJ. CRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseases. Molecular Neurodegeneration. 10: 35. PMID 26238861 DOI: 10.1186/S13024-015-0031-X  0.315
2015 Jiang W, Wei W, Gaertig MA, Li S, Li XJ. Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model. Plos One. 10: e0134142. PMID 26225560 DOI: 10.1371/Journal.Pone.0134142  0.505
2015 Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8345-58. PMID 26019347 DOI: 10.1523/Jneurosci.0772-15.2015  0.363
2015 Chan AW, Jiang J, Chen Y, Li C, Prucha MS, Hu Y, Chi T, Moran S, Rahim T, Li S, Li X, Zola SM, Testa CM, Mao H, Villalba R, et al. Progressive cognitive deficit, motor impairment and striatal pathology in a transgenic Huntington disease monkey model from infancy to adulthood. Plos One. 10: e0122335. PMID 25966278 DOI: 10.1371/Journal.Pone.0122335  0.395
2015 Chang R, Liu X, Li S, Li XJ. Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy. Drug Design, Development and Therapy. 9: 2179-88. PMID 25931812 DOI: 10.2147/Dddt.S58470  0.485
2015 Xiang J, Yan S, Li SH, Li XJ. Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice. Plos Genetics. 11: e1005175. PMID 25875952 DOI: 10.1371/Journal.Pgen.1005175  0.35
2015 Huang B, Wei W, Wang G, Gaertig MA, Feng Y, Wang W, Li XJ, Li S. Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 85: 1212-26. PMID 25789755 DOI: 10.1016/J.Neuron.2015.02.026  0.437
2015 Jiang W, Li SH, Li X. Therapeutic potential of berberine against neurodegenerative diseases Science China-Life Sciences. 58: 564-569. PMID 25749423 DOI: 10.1007/S11427-015-4829-0  0.339
2015 Yin P, Tu Z, Yin A, Zhao T, Yan S, Guo X, Chang R, Zhang L, Hong Y, Huang X, Zhou J, Wang Y, Li S, Li XJ. Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Human Molecular Genetics. 24: 1350-62. PMID 25343992 DOI: 10.1093/Hmg/Ddu544  0.451
2015 Li XJ, Li S. Large Animal Models of Huntington's Disease. Current Topics in Behavioral Neurosciences. 22: 149-60. PMID 24048953 DOI: 10.1007/7854_2013_246  0.488
2014 Wade BE, Wang CE, Yan S, Bhat K, Huang B, Li S, Li XJ. Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8411-22. PMID 24948797 DOI: 10.1523/Jneurosci.0775-14.2014  0.819
2014 Bhat KP, Yan S, Wang CE, Li S, Li XJ. Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proceedings of the National Academy of Sciences of the United States of America. 111: 5706-11. PMID 24706802 DOI: 10.1073/Pnas.1402215111  0.437
2014 Yang S, Huang S, Gaertig MA, Li XJ, Li S. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron. 81: 349-65. PMID 24462098 DOI: 10.1016/J.Neuron.2013.12.002  0.494
2014 Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S, Li XJ. TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain. Human Molecular Genetics. 23: 2678-93. PMID 24381309 DOI: 10.1093/Hmg/Ddt662  0.515
2014 Xiang J, Yang H, Zhao T, Sun M, Xu X, Zhou XF, Li SH, Li XJ. Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. The Journal of Clinical Investigation. 124: 85-98. PMID 24355921 DOI: 10.1172/Jci69206  0.469
2013 Xu Q, Huang S, Song M, Wang CE, Yan S, Liu X, Gaertig MA, Yu SP, Li H, Li S, Li XJ. Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. The Journal of Cell Biology. 202: 1123-38. PMID 24081492 DOI: 10.1083/Jcb.201303146  0.453
2013 Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S, Li XJ. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8172-84. PMID 23658157 DOI: 10.1523/Jneurosci.0119-13.2013  0.397
2012 Li XJ, Li S. Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 39: 239-45. PMID 22749010 DOI: 10.1016/J.Jgg.2012.05.002  0.459
2012 Li XJ, Li W. Beyond mice: genetically modifying larger animals to model human diseases. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 39: 237-8. PMID 22749009 DOI: 10.1016/J.Jgg.2012.05.006  0.337
2012 Li S, Li XJ. A huntingtin-HAP1-PCM1 pathway in ciliogenesis. Expert Review of Proteomics. 9: 17-9. PMID 22292820 DOI: 10.1586/Epr.11.72  0.47
2012 Cape A, Chen X, Wang CE, O'Neill A, Lin YF, He J, Xu XS, Yi H, Li H, Li S, Li XJ. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cellular and Molecular Life Sciences : Cmls. 69: 1305-17. PMID 21544547 DOI: 10.1007/S00018-011-0692-8  0.775
2012 Li X, Li S. Neuropathology of transgenic HD animal models Molecular Neurodegeneration. 7: 1-1. DOI: 10.1186/1750-1326-7-S1-L17  0.415
2011 Mandal M, Wei J, Zhong P, Cheng J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z. Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. The Journal of Biological Chemistry. 286: 33719-28. PMID 21832090 DOI: 10.1074/Jbc.M111.236521  0.448
2011 Huang S, Ling JJ, Yang S, Li XJ, Li S. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain : a Journal of Neurology. 134: 1943-58. PMID 21705419 DOI: 10.1093/Brain/Awr146  0.55
2011 Yang M, Lim Y, Li X, Zhong J, Zhou X. Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing Journal of Biological Chemistry. 286: 16272-16284. PMID 21357693 DOI: 10.1074/Jbc.M110.195347  0.451
2011 Havel LS, Wang CE, Wade B, Huang B, Li S, Li XJ. Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Human Molecular Genetics. 20: 1424-37. PMID 21245084 DOI: 10.1093/Hmg/Ddr023  0.82
2011 Li XJ, Li S. Proteasomal dysfunction in aging and Huntington disease. Neurobiology of Disease. 43: 4-8. PMID 21145396 DOI: 10.1016/J.Nbd.2010.11.018  0.492
2010 Wang CE, Li S, Li XJ. Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice. Molecular Brain. 3: 33. PMID 21044321 DOI: 10.1186/1756-6606-3-33  0.423
2010 Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 107: 19126-31. PMID 20956301 DOI: 10.1073/Pnas.1013032107  0.795
2010 Yang D, Wang CE, Zhao B, Li W, Ouyang Z, Liu Z, Yang H, Fan P, O'Neill A, Gu W, Yi H, Li S, Lai L, Li XJ. Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Human Molecular Genetics. 19: 3983-94. PMID 20660116 DOI: 10.1093/hmg/ddq313  0.443
2010 Li XJ, Li H, Li S. Clearance of mutant huntingtin. Autophagy. 6: 663-4. PMID 20519964 DOI: 10.4161/Auto.6.5.12336  0.505
2010 Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Human Molecular Genetics. 19: 2445-55. PMID 20354076 DOI: 10.1093/Hmg/Ddq127  0.519
2010 Lin YF, Xu X, Cape A, Li S, Li XJ. Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. The Journal of Biological Chemistry. 285: 15941-9. PMID 20304926 DOI: 10.1074/Jbc.M110.107318  0.82
2010 Bradford JW, Li S, Li XJ. Polyglutamine toxicity in non-neuronal cells. Cell Research. 20: 400-7. PMID 20231860 DOI: 10.1038/cr.2010.32  0.408
2010 Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. The Journal of Biological Chemistry. 285: 10653-61. PMID 20145253 DOI: 10.1074/jbc.M109.083287  0.701
2010 Wu LL, Fan Y, Li S, Li XJ, Zhou XF. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. The Journal of Biological Chemistry. 285: 5614-23. PMID 19996106 DOI: 10.1074/Jbc.M109.073197  0.357
2010 Li XJ, Orr AL, Li S. Impaired mitochondrial trafficking in Huntington's disease. Biochimica Et Biophysica Acta. 1802: 62-5. PMID 19591925 DOI: 10.1016/J.Bbadis.2009.06.008  0.735
2009 Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proceedings of the National Academy of Sciences of the United States of America. 106: 22480-5. PMID 20018729 DOI: 10.1073/pnas.0911503106  0.715
2009 Friedman MJ, Li S, Li XJ. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. The Journal of Biological Chemistry. 284: 27944-51. PMID 19656944 DOI: 10.1074/Jbc.M109.037937  0.813
2009 Shah AG, Friedman MJ, Huang S, Roberts M, Li XJ, Li S. Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Human Molecular Genetics. 18: 4141-52. PMID 19643914 DOI: 10.1093/Hmg/Ddp363  0.842
2009 Havel LS, Li S, Li XJ. Nuclear accumulation of polyglutamine disease proteins and neuropathology. Molecular Brain. 2: 21. PMID 19575804 DOI: 10.1186/1756-6606-2-21  0.807
2009 Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nature Neuroscience. 12: 872-8. PMID 19525944 DOI: 10.1038/Nn.2341  0.684
2008 Tydlacka S, Wang CE, Wang X, Li S, Li XJ. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13285-95. PMID 19052220 DOI: 10.1523/Jneurosci.4393-08.2008  0.816
2008 Zhou LL, Zhao Y, Ringrose A, DeGeer D, Kennah E, Lin AE, Sheng G, Li XJ, Turhan A, Jiang X. AHI-1 interacts with BCR-ABL and modulates BCR-ABL transforming activity and imatinib response of CML stem/progenitor cells. The Journal of Experimental Medicine. 205: 2657-71. PMID 18936234 DOI: 10.1084/Jem.20072316  0.308
2008 Li X, Li H, Li XJ. Intracellular degradation of misfolded proteins in polyglutamine neurodegenerative diseases. Brain Research Reviews. 59: 245-52. PMID 18773920 DOI: 10.1016/J.Brainresrev.2008.08.003  0.491
2008 Sheng G, Xu X, Lin YF, Wang CE, Rong J, Cheng D, Peng J, Jiang X, Li SH, Li XJ. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. The Journal of Clinical Investigation. 118: 2785-95. PMID 18636121 DOI: 10.1172/Jci35339  0.777
2008 Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human Molecular Genetics. 17: 2738-51. PMID 18558632 DOI: 10.1093/Hmg/Ddn175  0.813
2008 Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6182-95. PMID 18550760 DOI: 10.1523/Jneurosci.0857-08.2008  0.488
2008 Wang CE, Zhou H, McGuire JR, Cerullo V, Lee B, Li SH, Li XJ. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. The Journal of Cell Biology. 181: 803-16. PMID 18504298 DOI: 10.1083/Jcb.200710158  0.504
2008 Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li XJ. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. The Journal of Biological Chemistry. 283: 16027-36. PMID 18400759 DOI: 10.1074/Jbc.M710606200  0.761
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