Tim G. Hales - Publications

Affiliations: 
The George Washington University, Washington, DC, United States 
Area:
Neuroscience Biology, Pharmacology

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Singleton S, Baptista-Hon DT, Edelsten E, McCaughey KS, Camplisson E, Hales TG. TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available μ-opioid receptor number. British Journal of Pharmacology. PMID 33555037 DOI: 10.1111/bph.15409  0.64
2020 Baptista-Hon DT, Smith M, Singleton S, Antonides LH, Nic Daeid N, McKenzie C, Hales TG. Activation of μ opioid receptors by MT-45 and its fluorinated derivatives. British Journal of Pharmacology. PMID 32246840 DOI: 10.1111/Bph.15064  0.64
2019 Davies P, Hales TG, Jensen AA, Peters JA. ZAC (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f83/2019.4  0.48
2019 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f72/2019.4  0.48
2019 Barnes NM, Hales TG, Lummis SCR, Niesler B, Peters JA. 5-HT3 receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f68/2019.4  0.48
2018 Gottschald Chiodi C, Baptista-Hon DT, Hunter WN, Hales TG. Amino acid substitutions in the human homomeric β3 GABAA receptor that enable activation by GABA. The Journal of Biological Chemistry. PMID 30545943 DOI: 10.1074/Jbc.Ra118.006229  0.64
2018 Elajnaf T, Baptista-Hon DT, Hales TG. Potent Inactivation-Dependent Inhibition of Adult and Neonatal NaV1.5 Channels by Lidocaine and Levobupivacaine. Anesthesia and Analgesia. PMID 29958221 DOI: 10.1213/Ane.0000000000003597  0.64
2017 Wright L, Baptista-Hon D, Bull F, Dalgaty F, Gallacher M, Ibbotson SH, Hales TG. Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. Pain. PMID 29194091 DOI: 10.1097/J.Pain.0000000000001096  0.32
2017 Bull FA, Baptista-Hon DT, Lambert JJ, Walwyn W, Hales TG. Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src. Scientific Reports. 7: 9969. PMID 28855588 DOI: 10.1038/S41598-017-10360-8  0.64
2017 Bull FA, Baptista-Hon DT, Sneddon C, Wright L, Walwyn W, Hales TG. Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation. Anesthesiology. PMID 28820778 DOI: 10.1097/Aln.0000000000001834  0.64
2016 Baptista-Hon DT, Gulbinaite S, Hales TG. Loop G in the GABAA receptor α1 subunit influences gating efficacy. The Journal of Physiology. PMID 27981574 DOI: 10.1113/Jp273752  0.64
2016 Baptista-Hon DT, Krah A, Zachariae U, Hales TG. A role for loop G in the β1 strand in GABAA receptor activation. The Journal of Physiology. PMID 27195487 DOI: 10.1113/Jp272463  0.64
2015 House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Silvio Gutkind J, Hales TG, Lee NH. Voltage-gated Na(+) Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling. Scientific Reports. 5: 11541. PMID 26096612 DOI: 10.1038/Srep11541  0.48
2015 Morton RA, Baptista-Hon DT, Hales TG, Lovinger DM. Agonist- and antagonist-induced up-regulation of surface 5-HT3 A receptors. British Journal of Pharmacology. 172: 4066-77. PMID 25989383 DOI: 10.1111/Bph.13197  0.48
2015 Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, Gottumukkala V, Gottschalk A, Gupta A, Gupta K, Hales TG, Hemmings HC, Hollmann MW, Kurz A, Ma D, et al. Consensus statement from the BJA Workshop on Cancer and Anaesthesia. British Journal of Anaesthesia. 114: 2-3. PMID 25104229 DOI: 10.1093/Bja/Aeu262  0.48
2015 Vickery ON, Baptista-Hon DT, Seeliger D, Hales TG, Zachariae U. Investigating the Effect of Sodium and Voltage on δ-Opioid Receptors Biophysical Journal. 108: 414a. DOI: 10.1016/J.Bpj.2014.11.2272  0.64
2014 Baptista-Hon DT, Robertson FM, Robertson GB, Owen SJ, Rogers GW, Lydon EL, Lee NH, Hales TG. Potent inhibition by ropivacaine of metastatic colon cancer SW620 cell invasion and NaV1.5 channel function. British Journal of Anaesthesia. 113: i39-i48. PMID 24852501 DOI: 10.1093/Bja/Aeu104  0.48
2013 Carland JE, Cooper MA, Livesey MR, Hales TG, Peters JA, Lambert JJ. Mutagenic analysis of the intracellular portals of the human 5-HT3A receptor. The Journal of Biological Chemistry. 288: 31592-601. PMID 24030822 DOI: 10.1074/Jbc.M113.503300  0.48
2013 Baptista-Hon DT, Deeb TZ, Lambert JJ, Peters JA, Hales TG. The minimum M3-M4 loop length of neurotransmitter-activated pentameric receptors is critical for the structural integrity of cytoplasmic portals. The Journal of Biological Chemistry. 288: 21558-68. PMID 23740249 DOI: 10.1074/Jbc.M113.481689  0.48
2012 Othman NA, Gallacher M, Deeb TZ, Baptista-Hon DT, Perry DC, Hales TG. Influences on blockade by t-butylbicyclo-phosphoro-thionate of GABA(A) receptor spontaneous gating, agonist activation and desensitization. The Journal of Physiology. 590: 163-78. PMID 22083597 DOI: 10.1113/Jphysiol.2011.213249  0.64
2012 Baptista-Hon DT, Deeb TZ, Othman NA, Sharp D, Hales TG. The 5-HT3B subunit affects high-potency inhibition of 5-HT3 receptors by morphine. British Journal of Pharmacology. 165: 693-704. PMID 21740409 DOI: 10.1111/J.1476-5381.2011.01582.X  0.64
2011 Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W. Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2. Molecular Pain. 7: 24. PMID 21486473 DOI: 10.1186/1744-8069-7-24  0.48
2011 Morton RA, Luo G, Davis MI, Hales TG, Lovinger DM. Fluorophore assisted light inactivation (FALI) of recombinant 5-HT₃A receptor constitutive internalization and function. Molecular and Cellular Neurosciences. 47: 79-92. PMID 21338684 DOI: 10.1016/J.Mcn.2011.02.007  0.48
2010 House CD, Vaske CJ, Schwartz AM, Obias V, Frank B, Luu T, Sarvazyan N, Irby R, Strausberg RL, Hales TG, Stuart JM, Lee NH. Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion. Cancer Research. 70: 6957-67. PMID 20651255 DOI: 10.1158/0008-5472.Can-10-1169  0.48
2010 Wu DF, Othman NA, Sharp D, Mahendra A, Deeb TZ, Hales TG. A conserved cysteine residue in the third transmembrane domain is essential for homomeric 5-HT3 receptor function. The Journal of Physiology. 588: 603-16. PMID 19933756 DOI: 10.1113/Jphysiol.2009.181719  0.64
2010 Peters JA, Cooper MA, Carland JE, Livesey MR, Hales TG, Lambert JJ. Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors. The Journal of Physiology. 588: 587-96. PMID 19933751 DOI: 10.1113/Jphysiol.2009.183137  0.48
2009 O'Brien TJ, Goodsaid F, Plack M, Harralson A, Harrouk W, Hales TG, Mandel HG, Perry DC, Kennedy K, Sarvazyan N, Chiappinelli VA. Development of an undergraduate pharmacogenomics curriculum. Pharmacogenomics. 10: 1979-86. PMID 19958096 DOI: 10.2217/Pgs.09.145  0.48
2009 Walwyn W, John S, Maga M, Evans CJ, Hales TG. Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons. Molecular Pharmacology. 76: 134-43. PMID 19357247 DOI: 10.1124/Mol.109.055913  0.48
2009 Deeb TZ, Sharp D, Hales TG. Direct subunit-dependent multimodal 5-hydroxytryptamine3 receptor antagonism by methadone. Molecular Pharmacology. 75: 908-17. PMID 19131665 DOI: 10.1124/Mol.108.053322  0.64
2009 Barnes NM, Hales TG, Lummis SC, Peters JA. The 5-HT3 receptor--the relationship between structure and function. Neuropharmacology. 56: 273-84. PMID 18761359 DOI: 10.1016/J.Neuropharm.2008.08.003  0.48
2009 Morton RA, Luo G, Davis MI, Hales TG, Lovinger DM. Ethanol and trafficking of 5-HT3A receptors Alcoholism: Clinical and Experimental Research. 33. DOI: 10.1111/J.1530-0277.2009.00957.X  0.48
2008 Livesey MR, Cooper MA, Deeb TZ, Carland JE, Kozuska J, Hales TG, Lambert JJ, Peters JA. Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor. The Journal of Biological Chemistry. 283: 19301-13. PMID 18474595 DOI: 10.1074/Jbc.M802406200  0.48
2008 Bollan KA, Baur R, Hales TG, Sigel E, Connolly CN. The promiscuous role of the epsilon subunit in GABAA receptor biogenesis. Molecular and Cellular Neurosciences. 37: 610-21. PMID 18206389 DOI: 10.1016/J.Mcn.2007.12.011  0.48
2008 Drisdel RC, Sharp D, Henderson T, Hales TG, Green WN. High affinity binding of epibatidine to serotonin type 3 receptors. The Journal of Biological Chemistry. 283: 9659-65. PMID 17702741 DOI: 10.1074/Jbc.M703672200  0.48
2007 Walwyn W, Evans CJ, Hales TG. Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 5092-104. PMID 17494695 DOI: 10.1523/Jneurosci.1157-07.2007  0.48
2007 Deeb TZ, Carland JE, Cooper MA, Livesey MR, Lambert JJ, Peters JA, Hales TG. Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor. The Journal of Biological Chemistry. 282: 6172-82. PMID 17200121 DOI: 10.1074/Jbc.M607698200  0.48
2007 McCartney MR, Deeb TZ, Henderson TN, Hales TG. Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating. Molecular Pharmacology. 71: 539-48. PMID 17090706 DOI: 10.1124/Mol.106.028597  0.64
2006 Peters JA, Carland JE, Cooper MA, Livesey MR, Deeb TZ, Hales TG, Lambert JJ. Novel structural determinants of single-channel conductance in nicotinic acetylcholine and 5-hydroxytryptamine type-3 receptors. Biochemical Society Transactions. 34: 882-6. PMID 17052220 DOI: 10.1042/Bst0340882  0.48
2006 Hales TG, Deeb TZ, Tang H, Bollan KA, King DP, Johnson SJ, Connolly CN. An asymmetric contribution to gamma-aminobutyric type A receptor function of a conserved lysine within TM2-3 of alpha1, beta2, and gamma2 subunits. The Journal of Biological Chemistry. 281: 17034-43. PMID 16627470 DOI: 10.1074/Jbc.M603599200  0.48
2006 Hales TG, Dunlop JI, Deeb TZ, Carland JE, Kelley SP, Lambert JJ, Peters JA. Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 281: 8062-71. PMID 16407231 DOI: 10.1074/Jbc.M513222200  0.48
2005 Wagner DA, Goldschen-Ohm MP, Hales TG, Jones MV. Kinetics and spontaneous open probability conferred by the epsilon subunit of the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10462-8. PMID 16280584 DOI: 10.1523/Jneurosci.1658-05.2005  0.48
2005 Peters JA, Hales TG, Lambert JJ. Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor. Trends in Pharmacological Sciences. 26: 587-94. PMID 16194573 DOI: 10.1016/J.Tips.2005.09.011  0.48
2005 Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG. Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Molecular Pharmacology. 68: 1688-98. PMID 16135785 DOI: 10.1124/Mol.105.014829  0.48
2005 Hales TG, Tang H, Bollan KA, Johnson SJ, King DP, McDonald NA, Cheng A, Connolly CN. The epilepsy mutation, gamma2(R43Q) disrupts a highly conserved inter-subunit contact site, perturbing the biogenesis of GABAA receptors. Molecular and Cellular Neurosciences. 29: 120-7. PMID 15866052 DOI: 10.1016/J.Mcn.2005.01.002  0.48
2004 Charles AC, Hales TG. From inhibition to excitation: functional effects of interaction between opioid receptors. Life Sciences. 76: 479-85. PMID 15556161 DOI: 10.1016/J.Lfs.2004.09.012  0.48
2004 Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. Biochemical Society Transactions. 32: 547-52. PMID 15157181 DOI: 10.1042/Bst0320547  0.48
2003 Charles AC, Mostovskaya N, Asas K, Evans CJ, Dankovich ML, Hales TG. Coexpression of delta-opioid receptors with micro receptors in GH3 cells changes the functional response to micro agonists from inhibitory to excitatory. Molecular Pharmacology. 63: 89-95. PMID 12488540 DOI: 10.1124/Mol.63.1.89  0.48
2003 Stewart A, Davies PA, Kirkness EF, Safa P, Hales TG. Introduction of the 5-HT 3B subunit alters the functional properties of 5-HT 3 receptors native to neuroblastoma cells Neuropharmacology. 44: 214-223. DOI: 10.1016/S0028-3908(02)00376-3  0.48
2002 Davies PA, McCartney MR, Wang W, Hales TG, Kirkness EF. Alternative transcripts of the GABA(A) receptor epsilon subunit in human and rat. Neuropharmacology. 43: 467-75. PMID 12367593 DOI: 10.1016/S0028-3908(02)00153-3  0.52
2001 Safa P, Boulter J, Hales TG. Functional properties of Cav1.3 (alpha1D) L-type Ca2+ channel splice variants expressed by rat brain and neuroendocrine GH3 cells. The Journal of Biological Chemistry. 276: 38727-37. PMID 11514547 DOI: 10.1074/Jbc.M103724200  0.48
2000 Piros ET, Charles AC, Song L, Evans CJ, Hales TG. Cloned δ-opioid receptors in GH3 cells inhibit spontaneous Ca2+ oscillations and prolactin release through K(IR) channel activation Journal of Neurophysiology. 83: 2691-2698. PMID 10805669 DOI: 10.1152/Jn.2000.83.5.2691  0.48
2000 Davies PA, Hoffmann EB, Carlisle HJ, Tyndale RF, Hales TG. The influence of an endogenous beta3 subunit on recombinant GABA(A) receptor assembly and pharmacology in WSS-1 cells and transiently transfected HEK293 cells. Neuropharmacology. 39: 611-20. PMID 10728882 DOI: 10.1016/S0028-3908(99)00163-X  0.48
1999 Charles AC, Piros ET, Evans CJ, Hales TG. L-type Ca2+ channels and K+ channels specifically modulate the frequency and amplitude of spontaneous Ca2+ oscillations and have distinct roles in prolactin release in GH3 cells. The Journal of Biological Chemistry. 274: 7508-15. PMID 10066818 DOI: 10.1074/Jbc.274.11.7508  0.48
1999 Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF. The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature. 397: 359-63. PMID 9950429 DOI: 10.1038/16941  0.48
1998 Bronstein JM, Hales TG, Tyndale RF, Charles AC. A conditionally immortalized glial cell line that expresses mature myelin proteins and functional GABA(A) receptors. Journal of Neurochemistry. 70: 483-91. PMID 9453541 DOI: 10.1046/J.1471-4159.1998.70020483.X  0.48
1998 Carlisle HJ, Hales TG, Schlinger BA. Characterization of neuronal zebra finch GABA(A) receptors: Steroid effects Journal of Comparative Physiology - a Sensory, Neural, and Behavioral Physiology. 182: 531-538. DOI: 10.1007/S003590050200  0.48
1996 Piros ET, Hales TG, Evans CJ. Functional analysis of cloned opioid receptors in transfected cell lines Neurochemical Research. 21: 1277-1285. PMID 8947917 DOI: 10.1007/Bf02532368  0.48
1995 Charles AC, Hales TG. Mechanisms of spontaneous calcium oscillations and action potentials in immortalized hypothalamic (GT1-7) neurons. Journal of Neurophysiology. 73: 56-64. PMID 7714589 DOI: 10.1152/Jn.1995.73.1.56  0.48
1994 Hales TG, Sanderson MJ, Charles AC. GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons. Neuroendocrinology. 59: 297-308. PMID 8159279 DOI: 10.1159/000126671  0.48
1994 Tyndale RF, Hales TG, Olsen RW, Tobin AJ. Distinctive patterns of GABAA receptor subunit mRNAs in 13 cell lines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 5417-28. PMID 8083745 DOI: 10.1523/Jneurosci.14-09-05417.1994  0.48
1992 Hales TG, Lambert JJ. Modulation of GABAA and glycine receptors by chlormethiazole. European Journal of Pharmacology. 210: 239-46. PMID 1319334 DOI: 10.1016/0014-2999(92)90410-6  0.48
1991 Hales TG, Lambert JJ. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. British Journal of Pharmacology. 104: 619-28. PMID 1665745 DOI: 10.1111/J.1476-5381.1991.Tb12479.X  0.48
1991 Hales TG, Lambert JJ. MODULATION OF THE GABAA RECEPTOR BY PROPOFOL Anesthesiology. 75: A587. DOI: 10.1097/00000542-199109001-00586  0.48
1990 Lambert JJ, Peters JA, Sturgess NC, Hales TG. Steroid modulation of the GABAA receptor complex: electrophysiological studies. Ciba Foundation Symposium. 153: 56-71; discussion 71. PMID 1963400 DOI: 10.1002/9780470513989.ch4  0.48
1989 Lambert JJ, Peters JA, Hales TG, Dempster J. The properties of 5-HT3 receptors in clonal cell lines studied by patch-clamp techniques. British Journal of Pharmacology. 97: 27-40. PMID 2720311 DOI: 10.1111/J.1476-5381.1989.Tb11920.X  0.48
1988 Peters JA, Hales TG, Lambert JJ. Divalent cations modulate 5-HT3 receptor-induced currents in N1E-115 neuroblastoma cells. European Journal of Pharmacology. 151: 491-5. PMID 2463926 DOI: 10.1016/0014-2999(88)90550-X  0.48
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