Kim A. Caldwell - Publications

The University of Alabama, Tuscaloosa, AL 
Molecular Biology, Neuroscience Biology

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gaeta AL, Willicott K, Willicott CW, McKay LE, Keogh CM, Altman TJ, Kimble LC, Yarbrough AL, Caldwell KA, Caldwell GA. Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a α-synuclein model of Parkinson's disease. Iscience. 26: 106859. PMID 37260751 DOI: 10.1016/j.isci.2023.106859  0.444
2023 Starr LA, McKay LE, Peter KN, Seyfarth LM, Berkowitz LA, Caldwell KA, Caldwell GA. Attenuation of Dopaminergic Neurodegeneration in a Parkinson's Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2. Journal of Developmental Biology. 11. PMID 37218814 DOI: 10.3390/jdb11020020  0.376
2023 Nourse JB, Russell SN, Moniz NA, Peter K, Seyfarth LM, Scott M, Park HA, Caldwell KA, Caldwell GA. Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models. Proceedings of the National Academy of Sciences of the United States of America. 120: e2210712120. PMID 36745808 DOI: 10.1073/pnas.2210712120  0.411
2022 Gaeta AL, Nourse JB, Willicott K, McKay LE, Keogh CM, Peter K, Russell SN, Hamamichi S, Berkowitz LA, Caldwell KA, Caldwell GA. Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans. Plos Genetics. 18: e1010115. PMID 35984862 DOI: 10.1371/journal.pgen.1010115  0.311
2022 Fanning S, Cirka H, Thies JL, Jeong J, Niemi SM, Yoon J, Ho GPH, Pacheco JA, Dettmer U, Liu L, Clish CB, Hodgetts KJ, Hutchinson JN, Muratore CR, Caldwell GA, ... Caldwell KA, et al. Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy. Npj Parkinson's Disease. 8: 74. PMID 35680956 DOI: 10.1038/s41531-022-00335-6  0.401
2021 van der Welle REN, Jobling R, Burns C, Sanza P, van der Beek JA, Fasano A, Chen L, Zwartkruis FJ, Zwakenberg S, Griffin EF, Ten Brink C, Veenendaal T, Liv N, van Ravenswaaij-Arts CMA, Lemmink HH, ... ... Caldwell KA, et al. Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation. Embo Molecular Medicine. e13258. PMID 33851776 DOI: 10.15252/emmm.202013258  0.348
2021 McGrath K, Agarwal S, Tonelli M, Dergai M, Gaeta AL, Shum AK, Lacoste J, Zhang Y, Wen W, Chung D, Wiersum G, Shevade A, Zaichick S, van Rossum DB, Shuvalova L, ... ... Caldwell KA, et al. A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33723042 DOI: 10.1073/pnas.2016730118  0.31
2020 Caldwell KA, Willicott CW, Caldwell GA. Modeling neurodegeneration in . Disease Models & Mechanisms. 13. PMID 33106318 DOI: 10.1242/dmm.046110  0.387
2019 Hartman JH, Gonzalez-Hunt C, Hall SM, Ryde IT, Caldwell KA, Caldwell GA, Meyer JN. Genetic Defects in Mitochondrial Dynamics in Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration. International Journal of Molecular Sciences. 20. PMID 31261893 DOI: 10.3390/Ijms20133202  0.455
2019 Gaeta AL, Caldwell KA, Caldwell GA. Found in Translation: The Utility of Alpha-Synuclein Models of Parkinson's Disease. Brain Sciences. 9. PMID 30925741 DOI: 10.3390/Brainsci9040073  0.508
2019 Daniels MJ, Nourse JB, Kim H, Sainati V, Schiavina M, Murrali MG, Pan B, Ferrie JJ, Haney CM, Moons R, Gould NS, Natalello A, Grandori R, Sobott F, Petersson EJ, ... ... Caldwell KA, et al. Cyclized NDGA modifies dynamic α-synuclein monomers preventing aggregation and toxicity. Scientific Reports. 9: 2937. PMID 30814575 DOI: 10.1038/S41598-019-39480-Z  0.381
2019 Griffin EF, Scopel SE, Stephen CA, Holzhauer AC, Vaji MA, Tuckey RA, Berkowitz LA, Caldwell KA, Caldwell GA. ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic . Disease Models & Mechanisms. PMID 30683808 DOI: 10.1242/Dmm.037218  0.358
2018 Griffin EF, Yan X, Caldwell KA, Caldwell GA. Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration. Human Molecular Genetics. 27: 4176-4193. PMID 30508205 DOI: 10.1093/Hmg/Ddy308  0.466
2018 Caldwell KA, Thies JL, Caldwell GA. No Country for Old Worms: A Systematic Review of the Application of to Investigate a Bacterial Source of Environmental Neurotoxicity in Parkinson's Disease. Metabolites. 8. PMID 30380609 DOI: 10.3390/Metabo8040070  0.504
2018 Kim H, Perentis RJ, Caldwell GA, Caldwell KA. Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models. Cell Death & Disease. 9: 555. PMID 29748634 DOI: 10.1038/S41419-018-0619-5  0.459
2018 Patel D, Xu C, Nagarajan S, Liu Z, Hemphill WO, Shi R, Uversky VN, Caldwell GA, Caldwell KA, Witt SN. Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease. Human Molecular Genetics. PMID 29452354 DOI: 10.1093/Hmg/Ddy059  0.335
2018 Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya Á, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, et al. The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity. Molecular Neurobiology. PMID 29429047 DOI: 10.1007/S12035-018-0881-7  0.497
2017 Martinez BA, Petersen DA, Gaeta AL, Stanley SP, Caldwell GA, Caldwell KA. Dysregulation of the mitochondrial unfolded protein response induces non-apoptotic dopaminergic neurodegeneration in C. elegans models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29030433 DOI: 10.1523/Jneurosci.1294-17.2017  0.512
2017 Griffin EF, Caldwell KA, Caldwell GA. Genetic and pharmacological discovery for Alzheimer's Disease using C. elegans. Acs Chemical Neuroscience. PMID 29022701 DOI: 10.1021/Acschemneuro.7B00361  0.409
2017 Zhang S, Glukhova SA, Caldwell KA, Caldwell GA. NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease. Human Molecular Genetics. 26: 3823-3836. PMID 28934392 DOI: 10.1093/Hmg/Ddx269  0.478
2017 Mor DE, Tsika E, Mazzulli JR, Gould NS, Kim H, Daniels MJ, Doshi S, Gupta P, Grossman JL, Tan VX, Kalb RG, Caldwell KA, Caldwell GA, Wolfe JH, Ischiropoulos H. Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration. Nature Neuroscience. PMID 28920936 DOI: 10.1038/Nn.4641  0.449
2017 Tardiff DF, Brown LE, Yan X, Trilles R, Jui NT, Barrasa MI, Caldwell KA, Caldwell GA, Schaus SE, Lindquist S. Dihydropyrimidine-thiones and clioquinol synergize to target β-amyloid cellular pathologies through a metal-dependent mechanism. Acs Chemical Neuroscience. PMID 28628299 DOI: 10.1021/Acschemneuro.7B00187  0.391
2017 Martinez BA, Caldwell KA, Caldwell GA. C. elegans as a model system to accelerate discovery for Parkinson disease. Current Opinion in Genetics & Development. 44: 102-109. PMID 28242493 DOI: 10.1016/J.Gde.2017.02.011  0.491
2016 Wang S, Zhang S, Xu C, Barron A, Galiano F, Patel D, Lee YJ, Caldwell GA, Caldwell KA, Witt SN. Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease. Plos One. 11: e0164465. PMID 27736935 DOI: 10.1371/Journal.Pone.0164465  0.443
2016 Watkins AL, Ray A, R Roberts L, Caldwell KA, Olson JB. The Prevalence and Distribution of Neurodegenerative Compound-Producing Soil Streptomyces spp. Scientific Reports. 6: 22566. PMID 26936423 DOI: 10.1038/Srep22566  0.34
2015 Martinez BA, Kim H, Ray A, Caldwell GA, Caldwell KA. A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans. Cell Death & Disease. 6: e1908. PMID 26469957 DOI: 10.1038/Cddis.2015.270  0.46
2015 Ray A, Rentas C, Caldwell GA, Caldwell KA. Phenazine derivatives cause proteotoxicity and stress in C. elegans. Neuroscience Letters. 584: 23-7. PMID 25304539 DOI: 10.1016/J.Neulet.2014.09.055  0.424
2014 Ray A, Zhang S, Rentas C, Caldwell KA, Caldwell GA. RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 16076-85. PMID 25429148 DOI: 10.1523/Jneurosci.1945-14.2014  0.461
2014 Wang S, Zhang S, Liou LC, Ren Q, Zhang Z, Caldwell GA, Caldwell KA, Witt SN. Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 111: E3976-85. PMID 25201965 DOI: 10.1073/Pnas.1411694111  0.416
2014 Caraveo G, Auluck PK, Whitesell L, Chung CY, Baru V, Mosharov EV, Yan X, Ben-Johny M, Soste M, Picotti P, Kim H, Caldwell KA, Caldwell GA, Sulzer D, Yue DT, et al. Calcineurin determines toxic versus beneficial responses to α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 111: E3544-52. PMID 25122673 DOI: 10.1073/Pnas.1413201111  0.389
2014 Knight AL, Yan X, Hamamichi S, Ajjuri RR, Mazzulli JR, Zhang MW, Daigle JG, Zhang S, Borom AR, Roberts LR, Lee SK, DeLeon SM, Viollet-Djelassi C, Krainc D, O'Donnell JM, ... Caldwell KA, et al. The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models. Cell Metabolism. 20: 145-57. PMID 24882066 DOI: 10.1016/J.Cmet.2014.04.017  0.423
2014 Matlack KE, Tardiff DF, Narayan P, Hamamichi S, Caldwell KA, Caldwell GA, Lindquist S. Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proceedings of the National Academy of Sciences of the United States of America. 111: 4013-8. PMID 24591589 DOI: 10.1073/Pnas.1402228111  0.396
2014 Bornhorst J, Chakraborty S, Meyer S, Lohren H, Brinkhaus SG, Knight AL, Caldwell KA, Caldwell GA, Karst U, Schwerdtle T, Bowman A, Aschner M. The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans. Metallomics : Integrated Biometal Science. 6: 476-90. PMID 24452053 DOI: 10.1039/C3Mt00325F  0.495
2014 Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156: 170-82. PMID 24439375 DOI: 10.1016/J.Cell.2013.11.047  0.457
2014 Ray A, Martinez BA, Berkowitz LA, Caldwell GA, Caldwell KA. Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model. Cell Death & Disease. 5: e984. PMID 24407237 DOI: 10.1038/Cddis.2013.513  0.416
2014 Thompson ML, Chen P, Yan X, Kim H, Borom AR, Roberts NB, Caldwell KA, Caldwell GA. TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS. Disease Models & Mechanisms. 7: 233-43. PMID 24311730 DOI: 10.1242/Jcs.150904  0.43
2014 Muñoz-Lobato F, Rodríguez-Palero MJ, Naranjo-Galindo FJ, Shephard F, Gaffney CJ, Szewczyk NJ, Hamamichi S, Caldwell KA, Caldwell GA, Link CD, Miranda-Vizuete A. Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases. Antioxidants & Redox Signaling. 20: 217-35. PMID 23641861 DOI: 10.1089/Ars.2012.5051  0.462
2013 Tardiff DF, Jui NT, Khurana V, Tambe MA, Thompson ML, Chung CY, Kamadurai HB, Kim HT, Lancaster AK, Caldwell KA, Caldwell GA, Rochet JC, Buchwald SL, Lindquist S. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (New York, N.Y.). 342: 979-83. PMID 24158909 DOI: 10.1126/Science.1245321  0.431
2013 Caldwell KA, Shu Y, Roberts NB, Caldwell GA, O'Donnell JM. Invertebrate models of dystonia. Current Neuropharmacology. 11: 16-29. PMID 23814534 DOI: 10.2174/157015913804999504  0.355
2013 Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E. Lysosomal impairment in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 725-32. PMID 23580333 DOI: 10.1002/Mds.25462  0.472
2013 Kautu BB, Carrasquilla A, Hicks ML, Caldwell KA, Caldwell GA. Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling. Neuroscience Letters. 541: 116-9. PMID 23485787 DOI: 10.1016/J.Neulet.2013.02.026  0.502
2012 Usenovic M, Knight AL, Ray A, Wong V, Brown KR, Caldwell GA, Caldwell KA, Stagljar I, Krainc D. Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity. Human Molecular Genetics. 21: 3785-94. PMID 22645275 DOI: 10.1093/Hmg/Dds206  0.499
2012 Dexter PM, Caldwell KA, Caldwell GA. A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 393-404. PMID 22403010 DOI: 10.1007/S13311-012-0109-X  0.518
2012 Harrington AJ, Yacoubian TA, Slone SR, Caldwell KA, Caldwell GA. Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2142-53. PMID 22323726 DOI: 10.1523/Jneurosci.2606-11.2012  0.54
2012 Tardiff DF, Tucci ML, Caldwell KA, Caldwell GA, Lindquist S. Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. The Journal of Biological Chemistry. 287: 4107-20. PMID 22147697 DOI: 10.1074/Jbc.M111.308668  0.64
2011 Treusch S, Hamamichi S, Goodman JL, Matlack KE, Chung CY, Baru V, Shulman JM, Parrado A, Bevis BJ, Valastyan JS, Han H, Lindhagen-Persson M, Reiman EM, Evans DA, Bennett DA, ... ... Caldwell KA, et al. Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (New York, N.Y.). 334: 1241-5. PMID 22033521 DOI: 10.1126/Science.1213210  0.388
2011 Tucci ML, Harrington AJ, Caldwell GA, Caldwell KA. Modeling dopamine neuron degeneration in Caenorhabditis elegans. Methods in Molecular Biology (Clifton, N.J.). 793: 129-48. PMID 21913098 DOI: 10.1007/978-1-61779-328-8_9  0.67
2011 Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, Dawson VL. Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Human Molecular Genetics. 20: 3933-42. PMID 21768216 DOI: 10.1093/Hmg/Ddr312  0.452
2011 Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, et al. TorsinA participates in endoplasmic reticulum-associated degradation. Nature Communications. 2: 393. PMID 21750546 DOI: 10.1038/Ncomms1383  0.363
2011 Zheng M, Cierpicki T, Burdette AJ, Utepbergenov D, Janczyk PŁ, Derewenda U, Stukenberg PT, Caldwell KA, Derewenda ZS. Structural features and chaperone activity of the NudC protein family. Journal of Molecular Biology. 409: 722-41. PMID 21530541 DOI: 10.1016/J.Jmb.2011.04.018  0.324
2011 Harrington AJ, Knight AL, Caldwell GA, Caldwell KA. Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease. Methods (San Diego, Calif.). 53: 220-5. PMID 21195766 DOI: 10.1016/J.Ymeth.2010.12.036  0.525
2011 Tucci ML, Caldwell GA, Caldwell KA. Cell culture to investigate neurotoxicity and neurodegeneration utilizing Caenorhabditis elegans Neuromethods. 56: 129-143. DOI: 10.1007/978-1-61779-077-5_6  0.484
2010 Yacoubian TA, Slone SR, Harrington AJ, Hamamichi S, Schieltz JM, Caldwell KA, Caldwell GA, Standaert DG. Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell Death & Disease. 1: e2. PMID 21152247 DOI: 10.1038/Cddis.2009.4  0.517
2010 Chen P, Burdette AJ, Porter JC, Ricketts JC, Fox SA, Nery FC, Hewett JW, Berkowitz LA, Breakefield XO, Caldwell KA, Caldwell GA. The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Human Molecular Genetics. 19: 3502-15. PMID 20584926 DOI: 10.1093/Hmg/Ddq266  0.376
2010 Pivtoraiko VN, Harrington AJ, Mader BJ, Luker AM, Caldwell GA, Caldwell KA, Roth KA, Shacka JJ. Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. Journal of Neurochemistry. 114: 1193-204. PMID 20534000 DOI: 10.1111/J.1471-4159.2010.06838.X  0.455
2010 Cao S, Hewett JW, Yokoi F, Lu J, Buckley AC, Burdette AJ, Chen P, Nery FC, Li Y, Breakefield XO, Caldwell GA, Caldwell KA. Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. Disease Models & Mechanisms. 3: 386-96. PMID 20223934 DOI: 10.1242/Dmm.003715  0.385
2010 Burdette AJ, Churchill PF, Caldwell GA, Caldwell KA. The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro. Cell Stress & Chaperones. 15: 605-17. PMID 20169475 DOI: 10.1007/S12192-010-0173-2  0.386
2010 Harrington AJ, Hamamichi S, Caldwell GA, Caldwell KA. C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 1282-95. PMID 20108318 DOI: 10.1002/Dvdy.22231  0.501
2010 Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, et al. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease Models & Mechanisms. 3: 194-208. PMID 20038714 DOI: 10.1242/Dmm.004267  0.442
2010 Ruan Q, Harrington AJ, Caldwell KA, Caldwell GA, Standaert DG. VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease. Neurobiology of Disease. 37: 330-8. PMID 19850127 DOI: 10.1016/J.Nbd.2009.10.011  0.511
2009 Caldwell KA, Tucci ML, Armagost J, Hodges TW, Chen J, Memon SB, Blalock JE, DeLeon SM, Findlay RH, Ruan Q, Webber PJ, Standaert DG, Olson JB, Caldwell GA. Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration. Plos One. 4: e7227. PMID 19806188 DOI: 10.1371/Journal.Pone.0007227  0.678
2009 Locke CJ, Kautu BB, Berry KP, Lee SK, Caldwell KA, Caldwell GA. Pharmacogenetic analysis reveals a post-developmental role for Rac GTPases in Caenorhabditis elegans GABAergic neurotransmission. Genetics. 183: 1357-72. PMID 19797046 DOI: 10.1534/Genetics.109.106880  0.375
2009 Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S. Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nature Chemical Biology. 5: 655-63. PMID 19597508 DOI: 10.1038/Nchembio.193  0.391
2009 Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S. Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature Genetics. 41: 308-15. PMID 19182805 DOI: 10.1038/Ng.300  0.453
2009 Faircloth LM, Churchill PF, Caldwell GA, Caldwell KA. The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro. Cell Stress & Chaperones. 14: 95-103. PMID 18626791 DOI: 10.1007/S12192-008-0061-1  0.363
2008 Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA. Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes. Journal of Visualized Experiments : Jove. PMID 19066512 DOI: 10.3791/835  0.509
2008 Locke C, Berry K, Kautu B, Lee K, Caldwell K, Caldwell G. Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants. Journal of Visualized Experiments : Jove. PMID 19066504 DOI: 10.3791/837  0.346
2008 Caldwell GA, Caldwell KA. Traversing a wormhole to combat Parkinson's disease. Disease Models & Mechanisms. 1: 32-6. PMID 19048050 DOI: 10.1242/Dmm.000257  0.488
2008 Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, et al. Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity. Molecular Brain. 1: 17. PMID 19021916 DOI: 10.1186/1756-6606-1-17  0.399
2008 Locke CJ, Fox SA, Caldwell GA, Caldwell KA. Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease. Neuroscience Letters. 439: 129-33. PMID 18514411 DOI: 10.1016/J.Neulet.2008.05.003  0.54
2008 Hamamichi S, Rivas RN, Knight AL, Cao S, Caldwell KA, Caldwell GA. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Proceedings of the National Academy of Sciences of the United States of America. 105: 728-33. PMID 18182484 DOI: 10.1073/Pnas.0711018105  0.506
2008 Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 145-50. PMID 18162536 DOI: 10.1073/Pnas.0710685105  0.421
2007 Howard RA, Sharma P, Hajjar C, Caldwell KA, Caldwell GA, du Breuil R, Moore R, Boyd L. Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation. Bmc Cell Biology. 8: 32. PMID 17663792 DOI: 10.1186/1471-2121-8-32  0.394
2006 Locke CJ, Williams SN, Schwarz EM, Caldwell GA, Caldwell KA. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Research. 1120: 23-34. PMID 16996038 DOI: 10.1016/J.Brainres.2006.08.067  0.363
2006 Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6985-96. PMID 16807328 DOI: 10.1523/Jneurosci.0746-06.2006  0.376
2006 Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.). 313: 324-8. PMID 16794039 DOI: 10.1126/Science.1129462  0.538
2005 Cao S, Gelwix CC, Caldwell KA, Caldwell GA. Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3801-12. PMID 15829632 DOI: 10.1523/Jneurosci.5157-04.2005  0.5
2004 Williams SN, Locke CJ, Braden AL, Caldwell KA, Caldwell GA. Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Human Molecular Genetics. 13: 2043-59. PMID 15254012 DOI: 10.1093/Hmg/Ddh209  0.377
2003 Aumais JP, Williams SN, Luo W, Nishino M, Caldwell KA, Caldwell GA, Lin SH, Yu-Lee LY. Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis. Journal of Cell Science. 116: 1991-2003. PMID 12679384 DOI: 10.1242/Jcs.00412  0.368
2003 Caldwell GA, Cao S, Sexton EG, Gelwix CC, Bevel JP, Caldwell KA. Suppression of polyglutamine-induced protein aggregation in Caenorhabditis elegans by torsin proteins. Human Molecular Genetics. 12: 307-19. PMID 12554684 DOI: 10.1093/Hmg/Ddg027  0.411
2001 Dawe AL, Caldwell KA, Harris PM, Morris NR, Caldwell GA. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Development Genes and Evolution. 211: 434-41. PMID 11685578 DOI: 10.1007/S004270100176  0.403
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