Gustavo Aguirre - Publications

Affiliations: 
Cornell University, Ithaca, NY, United States 
Area:
Neuroscience Biology, Animal Physiology Biology, Veterinary Science Biology

99 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Badiei A, Sudharsan R, Santana E, Dunaief JL, Aguirre GD. Comparative localization of cystathionine beta synthases and cystathionine gamma lyase in canine, non-human primate and human retina. Experimental Eye Research. PMID 30653965 DOI: 10.1016/j.exer.2019.01.007  0.6
2018 Murgiano L, Becker D, Torjman D, Niggel JK, Milano A, Cullen C, Feng R, Wang F, Jagannathan V, Pearce-Kelling S, Katz ML, Leeb T, Aguirre GD. Complex Structural Variant Associated with Non-syndromic Canine Retinal Degeneration. G3 (Bethesda, Md.). PMID 30541930 DOI: 10.1534/g3.118.200859  0.36
2018 Sudharsan R, Beiting DP, Aguirre GD, Beltran WA. Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Scientific Reports. 8: 17041. PMID 30429513 DOI: 10.1038/s41598-018-35520-2  0.6
2018 Hardcastle AJ, Sieving PA, Sahel JA, Jacobson SG, Cideciyan AV, Flannery JG, Beltran WA, Aguirre GD. Translational Retinal Research and Therapies. Translational Vision Science & Technology. 7: 8. PMID 30225158 DOI: 10.1167/tvst.7.5.8  0.6
2018 Das RG, Marinho FP, Iwabe S, Santana E, McDaid KS, Aguirre GD, Miyadera K. Author Correction: Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. Scientific Reports. 8: 13058. PMID 30139995 DOI: 10.1038/s41598-018-31337-1  0.44
2018 Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC. Ndr kinases regulate retinal interneuron proliferation and homeostasis. Scientific Reports. 8: 12544. PMID 30135513 DOI: 10.1038/s41598-018-30492-9  0.6
2018 Cideciyan AV, Sudharsan R, Dufour VL, Massengill MT, Iwabe S, Swider M, Lisi B, Sumaroka A, Marinho LF, Appelbaum T, Rossmiller B, Hauswirth WW, Jacobson SG, Lewin AS, Aguirre GD, et al. Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127005 DOI: 10.1073/pnas.1805055115  0.6
2018 Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA. Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Advances in Experimental Medicine and Biology. 1074: 593-601. PMID 29721992 DOI: 10.1007/978-3-319-75402-4_72  0.6
2018 Guziewicz KE, McTish E, Dufour VL, Zorych K, Dhingra A, Boesze-Battaglia K, Aguirre GD. Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies. Advances in Experimental Medicine and Biology. 1074: 309-315. PMID 29721958 DOI: 10.1007/978-3-319-75402-4_38  0.32
2018 Guziewicz KE, Cideciyan AV, Beltran WA, Komáromy AM, Dufour VL, Swider M, Iwabe S, Sumaroka A, Kendrick BT, Ruthel G, Chiodo VA, Héon E, Hauswirth WW, Jacobson SG, Aguirre GD. gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507198 DOI: 10.1073/pnas.1720662115  0.6
2017 Sudharsan R, Beiting DP, Aguirre GD, Beltran WA. Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Scientific Reports. 7: 17897. PMID 29263354 DOI: 10.1038/s41598-017-18236-7  0.6
2017 Ye GJ, Komaromy AM, Zeiss CJ, Calcedo R, Harman CD, Koehl KL, Stewart G, Iwabe S, Chiodo V, Hauswirth WW, Aguirre G, Chulay JD. Safety and Efficacy of AAV5 Vectors Expressing Human or Canine CNGB3 in CNGB3-mutant Dogs. Human Gene Therapy. Clinical Development. PMID 29020838 DOI: 10.1089/humc.2017.125  0.44
2017 Das RG, Marinho FP, Iwabe S, Santana E, McDaid KS, Aguirre GD, Miyadera K. Variabilities in retinal function and structure in a canine model of cone-rod dystrophy associated with RPGRIP1 support multigenic etiology. Scientific Reports. 7: 12823. PMID 28993665 DOI: 10.1038/s41598-017-13112-w  0.44
2017 Bunya VY, Iwabe S, Macchi I, Massaro-Giordano M, Pistilli M, Aguirre GD. Tolerability of Topical Tocilizumab Eyedrops in Dogs: A Pilot Study. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 28650215 DOI: 10.1089/jop.2017.0017  0.44
2017 Beltran WA, Cideciyan AV, Boye SE, Ye GJ, Iwabe S, Dufour VL, Marinho LF, Swider M, Kosyk MS, Sha J, Boye SL, Peterson JJ, Witherspoon CD, Alexander JJ, Ying GS, ... ... Aguirre GD, et al. Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28566226 DOI: 10.1016/j.ymthe.2017.05.004  0.6
2017 Sudharsan R, Simone KM, Anderson NP, Aguirre GD, Beltran WA. Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 58: 270-281. PMID 28114588 DOI: 10.1167/iovs.16-20749  0.6
2017 Guziewicz KE, Sinha D, Gómez NM, Zorych K, Dutrow EV, Dhingra A, Mullins RF, Stone EM, Gamm DM, Boesze-Battaglia K, Aguirre GD. Bestrophinopathy: An RPE-photoreceptor interface disease. Progress in Retinal and Eye Research. PMID 28111324 DOI: 10.1016/j.preteyeres.2017.01.005  0.32
2016 Downs LM, Scott EM, Cideciyan AV, Iwabe S, Dufour V, Gardiner KL, Genini S, Marinho LF, Sumaroka A, Kosyk MS, Swider M, Aguirre GK, Jacobson SG, Beltran WA, Aguirre GD. Overlap of Abnormal Photoreceptor Development and Progressive Degeneration in Leber Congenital Amaurosis Caused by NPHP5 Mutation. Human Molecular Genetics. PMID 27506978 DOI: 10.1093/hmg/ddw254  0.6
2016 Iwabe S, Ying GS, Aguirre GD, Beltran WA. Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog. Experimental Eye Research. 146: 341-353. PMID 27085210 DOI: 10.1016/j.exer.2016.04.006  0.6
2016 Gardiner KL, Downs L, Berta-Antalics AI, Santana E, Aguirre GD, Genini S. Photoreceptor proliferation and dysregulation of cell cycle genes in early onset inherited retinal degenerations. Bmc Genomics. 17: 221. PMID 26969498 DOI: 10.1186/s12864-016-2477-9  0.4
2016 Downs LM, Aguirre GD. FAM161A and TTC8 are Differentially Expressed in Non-Allelelic Early Onset Retinal Degeneration. Advances in Experimental Medicine and Biology. 854: 201-7. PMID 26427412 DOI: 10.1007/978-3-319-17121-0_27  0.48
2015 Beltran WA, Cideciyan AV, Iwabe S, Swider M, Kosyk MS, McDaid K, Martynyuk I, Ying GS, Shaffer J, Deng WT, Boye SL, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease. Proceedings of the National Academy of Sciences of the United States of America. 112: E5844-53. PMID 26460017 DOI: 10.1073/pnas.1509914112  0.32
2015 Tanaka N, Dutrow EV, Miyadera K, Delemotte L, MacDermaid CM, Reinstein SL, Crumley WR, Dixon CJ, Casal ML, Klein ML, Aguirre GD, Tanaka JC, Guziewicz KE. Canine CNGA3 Gene Mutations Provide Novel Insights into Human Achromatopsia-Associated Channelopathies and Treatment. Plos One. 10: e0138943. PMID 26407004 DOI: 10.1371/journal.pone.0138943  0.32
2015 Kondo M, Das G, Imai R, Santana E, Nakashita T, Imawaka M, Ueda K, Ohtsuka H, Sakai K, Aihara T, Kato K, Sugimoto M, Ueno S, Nishizawa Y, Aguirre GD, et al. A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. Plos One. 10: e0137072. PMID 26368928 DOI: 10.1371/journal.pone.0137072  0.48
2015 Singh R, Kuai D, Guziewicz KE, Meyer J, Wilson M, Lu J, Smith M, Clark E, Verhoeven A, Aguirre GD, Gamm DM. TAPharmacological modulation of photoreceptor outer segment degradation in a human iPS cell model of inherited macular degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26300224 DOI: 10.1038/mt.2015.141  0.48
2015 Marsili S, Genini S, Sudharsan R, Gingrich J, Aguirre GD, Beltran WA. Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. Plos One. 10: e0115723. PMID 25695253 DOI: 10.1371/journal.pone.0115723  0.6
2015 Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. Cold Spring Harbor Perspectives in Medicine. 5: a017392. PMID 25301933 DOI: 10.1101/cshperspect.a017392  0.32
2014 Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5574-83. PMID 25489083 DOI: 10.1073/pnas.1414162111  0.6
2014 Genini S, Beltran WA, Stein VM, Aguirre GD. Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina. Advances in Experimental Medicine and Biology. 801: 339-45. PMID 24664716 DOI: 10.1007/978-1-4614-3209-8_43  0.6
2014 Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD. Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations. Plos One. 9: e90390. PMID 24599007 DOI: 10.1371/journal.pone.0090390  0.6
2014 Genini S, Guziewicz KE, Beltran WA, Aguirre GD. Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration. Bmc Genomics. 15: 172. PMID 24581223 DOI: 10.1186/1471-2164-15-172  0.6
2013 Genini S, Beltran WA, Aguirre GD. Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration. Plos One. 8: e85408. PMID 24367709 DOI: 10.1371/journal.pone.0085408  0.6
2013 Guziewicz KE, Zangerl B, Komáromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD. Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects. Plos One. 8: e75666. PMID 24143172 DOI: 10.1371/journal.pone.0075666  0.48
2013 Goldstein O, Mezey JG, Schweitzer PA, Boyko AR, Gao C, Bustamante CD, Jordan JA, Aguirre GD, Acland GM. IQCB1 and PDE6B mutations cause similar early onset retinal degenerations in two closely related terrier dog breeds. Investigative Ophthalmology & Visual Science. 54: 7005-19. PMID 24045995 DOI: 10.1167/iovs.13-12915  0.36
2013 Goldstein O, Jordan JA, Aguirre GD, Acland GM. A non-stop S-antigen gene mutation is associated with late onset hereditary retinal degeneration in dogs. Molecular Vision. 19: 1871-84. PMID 24019744  0.48
2013 Cideciyan AV, Jacobson SG, Beltran WA, Hauswirth WW, Aguirre GD. Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 110: E1706. PMID 23789127 DOI: 10.1073/pnas.1304296110  0.6
2013 Komáromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD. Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1131-41. PMID 23568263 DOI: 10.1038/mt.2013.50  0.48
2013 Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komáromy AM, Hauswirth WW, Aguirre GD. Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proceedings of the National Academy of Sciences of the United States of America. 110: E517-25. PMID 23341635 DOI: 10.1073/pnas.1218933110  0.48
2012 Kuznetsova T, Iwabe S, Boesze-Battaglia K, Pearce-Kelling S, Chang-Min Y, McDaid K, Miyadera K, Komaromy A, Aguirre GD. Exclusion of RPGRIP1 ins44 from primary causal association with early-onset cone-rod dystrophy in dogs. Investigative Ophthalmology & Visual Science. 53: 5486-501. PMID 22807295 DOI: 10.1167/iovs.12-10178  0.44
2012 Hoffmann I, Guziewicz KE, Zangerl B, Aguirre GD, Mardin CY. Canine multifocal retinopathy in the Australian Shepherd: a case report. Veterinary Ophthalmology. 15: 134-8. PMID 22432598 DOI: 10.1111/j.1463-5224.2012.01005.x  0.32
2012 Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Alemán TS, Boye SL, Genini S, Swaroop A, ... ... Aguirre GD, et al. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 109: 2132-7. PMID 22308428 DOI: 10.1073/pnas.1118847109  0.6
2012 Guziewicz KE, Aguirre GD, Zangerl B. Modeling the structural consequences of BEST1 missense mutations. Advances in Experimental Medicine and Biology. 723: 611-8. PMID 22183385 DOI: 10.1007/978-1-4614-0631-0_78  0.32
2012 Genini S, Beltran WA, Aguirre GD. Development and validation of a canine-specific profiling array to examine expression of pro-apoptotic and pro-survival genes in retinal degenerative diseases. Advances in Experimental Medicine and Biology. 723: 353-63. PMID 22183353 DOI: 10.1007/978-1-4614-0631-0_46  0.6
2012 Miyadera K, Acland GM, Aguirre GD. Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 40-61. PMID 22065099 DOI: 10.1007/s00335-011-9361-3  0.36
2011 Berta ÁI, Boesze-Battaglia K, Genini S, Goldstein O, O'Brien PJ, Szél Á, Acland GM, Beltran WA, Aguirre GD. Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina. Plos One. 6: e24074. PMID 21980341 DOI: 10.1371/journal.pone.0024074  0.6
2011 Guziewicz KE, Slavik J, Lindauer SJ, Aguirre GD, Zangerl B. Molecular consequences of BEST1 gene mutations in canine multifocal retinopathy predict functional implications for human bestrophinopathies. Investigative Ophthalmology & Visual Science. 52: 4497-505. PMID 21498618 DOI: 10.1167/iovs.10-6385  0.32
2011 Kuznetsova T, Zangerl B, Goldstein O, Acland GM, Aguirre GD. Structural organization and expression pattern of the canine RPGRIP1 isoforms in retinal tissue. Investigative Ophthalmology & Visual Science. 52: 2989-98. PMID 21282582 DOI: 10.1167/iovs.10-6094  0.36
2010 Zangerl B, Wickström K, Slavik J, Lindauer SJ, Ahonen S, Schelling C, Lohi H, Guziewicz KE, Aguirre GD. Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3). Molecular Vision. 16: 2791-804. PMID 21197113  0.32
2010 Goldstein O, Kukekova AV, Aguirre GD, Acland GM. Exonic SINE insertion in STK38L causes canine early retinal degeneration (erd). Genomics. 96: 362-8. PMID 20887780 DOI: 10.1016/j.ygeno.2010.09.003  0.36
2010 Goldstein O, Mezey JG, Boyko AR, Gao C, Wang W, Bustamante CD, Anguish LJ, Jordan JA, Pearce-Kelling SE, Aguirre GD, Acland GM. An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9. Molecular Vision. 16: 1549-69. PMID 20806078  0.32
2010 Goldstein O, Guyon R, Kukekova A, Kuznetsova TN, Pearce-Kelling SE, Johnson J, Aguirre GD, Acland GM. COL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 21: 398-408. PMID 20686772 DOI: 10.1007/s00335-010-9276-4  0.36
2010 Genini S, Zangerl B, Slavik J, Acland GM, Beltran WA, Aguirre GD. Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration. Investigative Ophthalmology & Visual Science. 51: 6038-50. PMID 20574030 DOI: 10.1167/iovs.10-5443  0.6
2010 Beltran WA, Boye SL, Boye SE, Chiodo VA, Lewin AS, Hauswirth WW, Aguirre GD. rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters. Gene Therapy. 17: 1162-74. PMID 20428215 DOI: 10.1038/gt.2010.56  0.6
2010 Komáromy AM, Alexander JJ, Rowlan JS, Garcia MM, Chiodo VA, Kaya A, Tanaka JC, Acland GM, Hauswirth WW, Aguirre GD. Gene therapy rescues cone function in congenital achromatopsia. Human Molecular Genetics. 19: 2581-93. PMID 20378608 DOI: 10.1093/hmg/ddq136  0.48
2009 Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ. CREB1/ATF1 activation in photoreceptor degeneration and protection. Investigative Ophthalmology & Visual Science. 50: 5355-63. PMID 19643965 DOI: 10.1167/iovs.09-3741  0.6
2009 Kukekova AV, Vorobieva NV, Beklemisheva VR, Johnson JL, Temnykh SV, Yudkin DV, Trut LN, Andre C, Galibert F, Aguirre GD, Acland GM, Graphodatsky AS. Chromosomal mapping of canine-derived BAC clones to the red fox and American mink genomes. The Journal of Heredity. 100: S42-53. PMID 19546120 DOI: 10.1093/jhered/esp037  0.36
2009 Beltran WA, Acland GM, Aguirre GD. Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations. Investigative Ophthalmology & Visual Science. 50: 3985-95. PMID 19255154 DOI: 10.1167/iovs.08-3364  0.6
2009 Gu D, Beltran WA, Pearce-Kelling S, Li Z, Acland GM, Aguirre GD. Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition. Investigative Ophthalmology & Visual Science. 50: 3482-94. PMID 19234347 DOI: 10.1167/iovs.08-3111  0.6
2009 Kukekova AV, Goldstein O, Johnson JL, Richardson MA, Pearce-Kelling SE, Swaroop A, Friedman JS, Aguirre GD, Acland GM. Canine RD3 mutation establishes rod-cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 109-23. PMID 19130129 DOI: 10.1007/s00335-008-9163-4  0.36
2008 Komáromy AM, Acland GM, Aguirre GD. Operating in the dark: a night-vision system for surgery in retinas susceptible to light damage. Archives of Ophthalmology (Chicago, Ill. : 1960). 126: 714-7. PMID 18474785 DOI: 10.1001/archopht.126.5.714  0.36
2008 Paez GL, Zangerl B, Sellers K, Acland GM, Aguirre GD. Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray Advances in Experimental Medicine and Biology. 613: 179-184. PMID 18188943 DOI: 10.1007/978-0-387-74904-4_20  0.36
2007 Gu D, Beltran WA, Li Z, Acland GM, Aguirre GD. Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina? Investigative Ophthalmology & Visual Science. 48: 4907-18. PMID 17962438 DOI: 10.1167/iovs.07-0428  0.6
2007 Parker HG, Kukekova AV, Akey DT, Goldstein O, Kirkness EF, Baysac KC, Mosher DS, Aguirre GD, Acland GM, Ostrander EA. Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds. Genome Research. 17: 1562-71. PMID 17916641 DOI: 10.1101/gr.6772807  0.36
2007 Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Human cone photoreceptor dependence on RPE65 isomerase. Proceedings of the National Academy of Sciences of the United States of America. 104: 15123-8. PMID 17848510 DOI: 10.1073/pnas.0706367104  0.6
2007 Guyon R, Pearce-Kelling SE, Zeiss CJ, Acland GM, Aguirre GD. Analysis of six candidate genes as potential modifiers of disease expression in canine XLPRA1, a model for human X-linked retinitis pigmentosa 3. Molecular Vision. 13: 1094-105. PMID 17653054  0.36
2007 Zangerl B, Johnson JL, Acland GM, Aguirre GD. Independent origin and restricted distribution of RPGR deletions causing XLPRA. The Journal of Heredity. 98: 526-30. PMID 17646274 DOI: 10.1093/jhered/esm060  0.36
2007 Traas AM, Wang P, Ma X, Tittiger M, Schaller L, O'donnell P, Sleeper MM, Vite C, Herati R, Aguirre GD, Haskins M, Ponder KP. Correction of clinical manifestations of canine mucopolysaccharidosis I with neonatal retroviral vector gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1423-31. PMID 17519893 DOI: 10.1038/sj.mt.6300201  0.48
2007 Guziewicz KE, Zangerl B, Lindauer SJ, Mullins RF, Sandmeyer LS, Grahn BH, Stone EM, Acland GM, Aguirre GD. Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease. Investigative Ophthalmology & Visual Science. 48: 1959-67. PMID 17460247 DOI: 10.1167/iovs.06-1374  0.48
2007 Hunter LS, Sidjanin DJ, Hijar MV, Johnson JL, Kirkness E, Acland GM, Aguirre GD. Cloning and characterization of canine PAX6 and evaluation as a candidate gene in a canine model of aniridia. Molecular Vision. 13: 431-42. PMID 17417604  0.48
2007 Beltran WA, Wen R, Acland GM, Aguirre GD. Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. Experimental Eye Research. 84: 753-71. PMID 17320077 DOI: 10.1016/j.exer.2006.12.019  0.32
2007 Kukekova AV, Trut LN, Oskina IN, Johnson JL, Temnykh SV, Kharlamova AV, Shepeleva DV, Gulievich RG, Shikhevich SG, Graphodatsky AS, Aguirre GD, Acland GM. A meiotic linkage map of the silver fox, aligned and compared to the canine genome. Genome Research. 17: 387-99. PMID 17284676 DOI: 10.1101/gr.5893307  0.48
2006 Komáromy AM, Varner SE, de Juan E, Acland GM, Aguirre GD. Application of a new subretinal injection device in the dog. Cell Transplantation. 15: 511-9. PMID 17121162  0.36
2006 Paez GL, Sellers KF, Band M, Acland GM, Zangerl B, Aguirre GD. Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray. Molecular Vision. 12: 1048-56. PMID 17093389  0.36
2006 Jacobson SG, Boye SL, Aleman TS, Conlon TJ, Zeiss CJ, Roman AJ, Cideciyan AV, Schwartz SB, Komaromy AM, Doobrajh M, Cheung AY, Sumaroka A, Pearce-Kelling SE, Aguirre GD, Kaushal S, et al. Safety in nonhuman primates of ocular AAV2-RPE65, a candidate treatment for blindness in Leber congenital amaurosis. Human Gene Therapy. 17: 845-58. PMID 16942444 DOI: 10.1089/hum.2006.17.845  0.48
2006 Zangerl B, Goldstein O, Philp AR, Lindauer SJ, Pearce-Kelling SE, Mullins RF, Graphodatsky AS, Ripoll D, Felix JS, Stone EM, Acland GM, Aguirre GD. Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans. Genomics. 88: 551-63. PMID 16938425 DOI: 10.1016/j.ygeno.2006.07.007  0.48
2006 Goldstein O, Zangerl B, Pearce-Kelling S, Sidjanin DJ, Kijas JW, Felix J, Acland GM, Aguirre GD. Linkage disequilibrium mapping in domestic dog breeds narrows the progressive rod-cone degeneration interval and identifies ancestral disease-transmitting chromosome. Genomics. 88: 541-50. PMID 16859891 DOI: 10.1016/j.ygeno.2006.05.013  0.48
2006 Hunter LS, Sidjanin DJ, Johnson JL, Zangerl B, Galibert F, Andre C, Kirkness E, Talamas E, Acland GM, Aguirre GD. Radiation hybrid mapping of cataract genes in the dog. Molecular Vision. 12: 588-96. PMID 16760895  0.48
2006 Zangerl B, Sun Q, Pillardy J, Johnson JL, Schweitzer PA, Hernandez AG, Liu L, Acland GM, Aguirre GD. Development and characterization of a normalized canine retinal cDNA library for genomic and expression studies. Investigative Ophthalmology & Visual Science. 47: 2632-8. PMID 16723480 DOI: 10.1167/iovs.05-1463  0.36
2006 Jacobson SG, Acland GM, Aguirre GD, Aleman TS, Schwartz SB, Cideciyan AV, Zeiss CJ, Komaromy AM, Kaushal S, Roman AJ, Windsor EA, Sumaroka A, Pearce-Kelling SE, Conlon TJ, Chiodo VA, et al. Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1074-84. PMID 16644289 DOI: 10.1016/j.ymthe.2006.03.005  0.36
2006 Beltran WA, Hammond P, Acland GM, Aguirre GD. A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa. Investigative Ophthalmology & Visual Science. 47: 1669-81. PMID 16565408 DOI: 10.1167/iovs.05-0845  0.6
2006 Kukekova AV, Nelson J, Kuchtey RW, Lowe JK, Johnson JL, Ostrander EA, Aguirre GD, Acland GM. Linkage mapping of canine rod cone dysplasia type 2 (rcd2) to CFA7, the canine orthologue of human 1q32. Investigative Ophthalmology & Visual Science. 47: 1210-5. PMID 16505060 DOI: 10.1167/iovs.05-0861  0.36
2005 Acland GM, Aguirre GD, Bennett J, Aleman TS, Cideciyan AV, Bennicelli J, Dejneka NS, Pearce-Kelling SE, Maguire AM, Palczewski K, Hauswirth WW, Jacobson SG. Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 1072-82. PMID 16226919 DOI: 10.1016/j.ymthe.2005.08.008  0.36
2005 Graphodatsky AS, Kukekova AV, Yudkin DV, Trifonov VA, Vorobieva NV, Beklemisheva VR, Perelman PL, Graphodatskaya DA, Trut LN, Yang F, Ferguson-Smith MA, Acland GM, Aguirre GD. The proto-oncogene C-KIT maps to canid B-chromosomes. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 13: 113-22. PMID 15861301 DOI: 10.1007/s10577-005-7474-9  0.36
2005 Beltran WA, Rohrer H, Aguirre GD. Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. Molecular Vision. 11: 232-44. PMID 15827545  0.48
2005 Cideciyan AV, Jacobson SG, Aleman TS, Gu D, Pearce-Kelling SE, Sumaroka A, Acland GM, Aguirre GD. In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 102: 5233-8. PMID 15784735 DOI: 10.1073/pnas.0408892102  0.36
2005 Akhmedov NB, Yamashita CK, Tran D, Piri NI, Aguirre GD, Farber DB. Two forms of the large tumor suppressor gene (Lats1) protein expressed in the vertebrate retina. Biochimica Et Biophysica Acta. 1728: 11-7. PMID 15777619 DOI: 10.1016/j.bbaexp.2005.01.003  0.48
2004 Zhu L, Jang GF, Jastrzebska B, Filipek S, Pearce-Kelling SE, Aguirre GD, Stenkamp RE, Acland GM, Palczewski K. A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor. The Journal of Biological Chemistry. 279: 53828-39. PMID 15459196 DOI: 10.1074/jbc.M408472200  0.36
2004 Kijas JW, Zangerl B, Miller B, Nelson J, Kirkness EF, Aguirre GD, Acland GM. Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies. Molecular Vision. 10: 223-32. PMID 15064680  0.48
2003 Zhang Q, Beltran WA, Mao Z, Li K, Johnson JL, Acland GM, Aguirre GD. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. Investigative Ophthalmology & Visual Science. 44: 4542-9. PMID 14507903  0.6
2003 Kukekova AV, Aguirre GD, Acland GM. Cloning and characterization of canine SHARP1 and its evaluation as a positional candidate for canine early retinal degeneration (erd). Gene. 312: 335-43. PMID 12909371  0.36
2003 Beltran WA, Zhang Q, Kijas JW, Gu D, Rohrer H, Jordan JA, Aguirre GD. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Investigative Ophthalmology & Visual Science. 44: 3642-9. PMID 12882818 DOI: 10.1167/iovs.02-0763  0.32
2003 Lowe JK, Kukekova AV, Kirkness EF, Langlois MC, Aguirre GD, Acland GM, Ostrander EA. Linkage mapping of the primary disease locus for collie eye anomaly. Genomics. 82: 86-95. PMID 12809679  0.36
2002 Ho TT, Maguire AM, Aguirre GD, Surace EM, Anand V, Zeng Y, Salvetti A, Hopwood JJ, Haskins ME, Bennett J. Phenotypic rescue after adeno-associated virus-mediated delivery of 4-sulfatase to the retinal pigment epithelium of feline mucopolysaccharidosis VI. The Journal of Gene Medicine. 4: 613-21. PMID 12439853 DOI: 10.1002/jgm.302  0.48
2002 Aguirre GD, Yashar BM, John SK, Smith JE, Breuer DK, Hiriyanna S, Swaroop A, Milam AH. Retinal histopathology of an XLRP carrier with a mutation in the RPGR exon ORF15. Experimental Eye Research. 75: 431-43. PMID 12387791 DOI: 10.1016/S0014-4835(02)92037-3  0.48
2002 Tao W, Wen R, Goddard MB, Sherman SD, O'Rourke PJ, Stabila PF, Bell WJ, Dean BJ, Kauper KA, Budz VA, Tsiaras WG, Acland GM, Pearce-Kelling S, Laties AM, Aguirre GD. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Investigative Ophthalmology & Visual Science. 43: 3292-8. PMID 12356837  0.36
2002 Sidjanin DJ, Lowe JK, McElwee JL, Milne BS, Phippen TM, Sargan DR, Aguirre GD, Acland GM, Ostrander EA. Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3. Human Molecular Genetics. 11: 1823-33. PMID 12140185  0.48
2002 Zhang Q, Acland GM, Wu WX, Johnson JL, Pearce-Kelling S, Tulloch B, Vervoort R, Wright AF, Aguirre GD. Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration. Human Molecular Genetics. 11: 993-1003. PMID 11978759  0.36
2002 Kijas JW, Cideciyan AV, Aleman TS, Pianta MJ, Pearce-Kelling SE, Miller BJ, Jacobson SG, Aguirre GD, Acland GM. Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 99: 6328-33. PMID 11972042 DOI: 10.1073/pnas.082714499  0.36
2002 Akhmedov NB, Baldwin VJ, Zangerl B, Kijas JW, Hunter L, Minoofar KD, Mellersh C, Ostrander EA, Acland GM, Farber DB, Aguirre GD. Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog. Molecular Vision. 8: 79-84. PMID 11951083  0.48
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