| Year |
Citation |
Score |
| 2019 |
Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN. The db mutation improves memory in younger mice in a model of Alzheimer's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 31034991 DOI: 10.1016/J.Bbadis.2019.04.013 |
0.334 |
|
| 2019 |
Szabo-Reed AN, Vidoni E, Binder EF, Burns J, Cullum CM, Gahan WP, Gupta A, Hynan LS, Kerwin DR, Rossetti H, Stowe AM, Vongpatanasin W, Zhu DC, Zhang R, Keller JN. Rationale and methods for a multicenter clinical trial assessing exercise and intensive vascular risk reduction in preventing dementia (rrAD Study). Contemporary Clinical Trials. PMID 30826452 DOI: 10.1016/J.Cct.2019.02.007 |
0.323 |
|
| 2016 |
Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Angeletti M, Keller JN, Eleuteri AM. The fine-tuning of proteolytic pathways in Alzheimer's disease. Cellular and Molecular Life Sciences : Cmls. PMID 27120560 DOI: 10.1007/S00018-016-2238-6 |
0.371 |
|
| 2016 |
Dasuri K, Pepping JK, Fernandez-Kim SO, Gupta S, Keller JN, Scherer PE, Bruce-Keller AJ. Elevated adiponectin prevents HIV Protease inhibitor toxicity and preserves cerebrovascular homeostasis in mice. Biochimica Et Biophysica Acta. PMID 26912411 DOI: 10.1016/J.Bbadis.2016.02.009 |
0.317 |
|
| 2016 |
Mohamed LA, Keller JN, Kaddoumi A. Role of P-glycoprotein in mediating rivastigmine effect on amyloid-β brain load and related pathology in Alzheimer's disease mouse model. Biochimica Et Biophysica Acta. PMID 26780497 DOI: 10.1016/J.Bbadis.2016.01.013 |
0.347 |
|
| 2015 |
Rebello CJ, Keller JN, Liu AG, Johnson WD, Greenway FL. Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: A randomized controlled trial. Bba Clinical. 3: 123-5. PMID 26675661 DOI: 10.1016/J.Bbacli.2015.01.001 |
0.308 |
|
| 2015 |
Dasuri K, Zhang L, Kim SO, Bruce-Keller AJ, Keller JN. Dietary and donepezil modulation of mTOR signaling and neuroinflammation in the brain. Biochimica Et Biophysica Acta. PMID 26554604 DOI: 10.1016/J.Bbadis.2015.11.002 |
0.382 |
|
| 2015 |
Qosa H, Batarseh YS, Mohyeldin MM, El Sayed KA, Keller JN, Kaddoumi A. Oleocanthal Enhances Amyloid-β Clearance from the Brains of TgSwDI Mice and in Vitro across a Human Blood-Brain Barrier Model. Acs Chemical Neuroscience. PMID 26348065 DOI: 10.1021/Acschemneuro.5B00190 |
0.334 |
|
| 2015 |
Qosa H, Mohamed LA, Batarseh YS, Alqahtani S, Ibrahim B, LeVine H, Keller JN, Kaddoumi A. Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice. The Journal of Nutritional Biochemistry. PMID 26344778 DOI: 10.1016/J.Jnutbio.2015.07.022 |
0.361 |
|
| 2015 |
Cecarini V, Bonfili L, Cuccioloni M, Keller JN, Bruce-Keller AJ, Eleuteri AM. Effects of Ghrelin on the Proteolytic Pathways of Alzheimer's Disease Neuronal Cells. Molecular Neurobiology. PMID 26033219 DOI: 10.1007/S12035-015-9227-X |
0.341 |
|
| 2015 |
MacAulay R, Cohen A, Brouillette R, Foil H, Keller J, Bruce-Keller A. Aging-3Towards a Cognitive Endophenotype Model of Preclinical Alzheimer's Disease Archives of Clinical Neuropsychology. 30: 478.3-479. DOI: 10.1093/Arclin/Acv046.11 |
0.306 |
|
| 2014 |
Qosa H, LeVine H, Keller JN, Kaddoumi A. Mixed oligomers and monomeric amyloid-β disrupts endothelial cells integrity and reduces monomeric amyloid-β transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model. Biochimica Et Biophysica Acta. 1842: 1806-15. PMID 24997450 DOI: 10.1016/J.Bbadis.2014.06.029 |
0.308 |
|
| 2014 |
Pepping JK, Otvos L, Surmacz E, Gupta S, Keller JN, Bruce-Keller AJ. Designer adiponectin receptor agonist stabilizes metabolic function and prevents brain injury caused by HIV protease inhibitors. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 388-98. PMID 24562631 DOI: 10.1007/S11481-014-9529-1 |
0.31 |
|
| 2014 |
Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, Kaddoumi A. Differences in amyloid-β clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology. 79: 668-78. PMID 24467845 DOI: 10.1016/J.Neuropharm.2014.01.023 |
0.347 |
|
| 2014 |
Cecarini V, Bonfili L, Cuccioloni M, Mozzicafreddo M, Rossi G, Keller JN, Angeletti M, Eleuteri AM. Wild type and mutant amyloid precursor proteins influence downstream effects of proteasome and autophagy inhibition. Biochimica Et Biophysica Acta. 1842: 127-34. PMID 24215712 DOI: 10.1016/J.Bbadis.2013.11.002 |
0.369 |
|
| 2013 |
Zhou J, Keenan MJ, Fernandez-Kim SO, Pistell PJ, Ingram DK, Li B, Raggio AM, Shen L, Zhang H, McCutcheon KL, Tulley RT, Blackman MR, Keller JN, Martin RJ. Dietary resistant starch improves selected brain and behavioral functions in adult and aged rodents. Molecular Nutrition & Food Research. 57: 2071-4. PMID 23818307 DOI: 10.1002/Mnfr.201300135 |
0.334 |
|
| 2013 |
Beckett TL, Studzinski CM, Keller JN, Paul Murphy M, Niedowicz DM. A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease. Brain Research. 1505: 61-7. PMID 23415649 DOI: 10.1016/J.Brainres.2013.01.046 |
0.356 |
|
| 2013 |
Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett TL, Murphy MP, Keller JN. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochimica Et Biophysica Acta. 1832: 1456-62. PMID 23313575 DOI: 10.1016/J.Bbadis.2013.01.002 |
0.334 |
|
| 2013 |
Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP. Leptin regulates amyloid β production via the γ-secretase complex. Biochimica Et Biophysica Acta. 1832: 439-44. PMID 23274884 DOI: 10.1016/J.Bbadis.2012.12.009 |
0.335 |
|
| 2013 |
Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ. NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. American Journal of Physiology. Endocrinology and Metabolism. 304: E392-404. PMID 23233541 DOI: 10.1152/Ajpendo.00398.2012 |
0.316 |
|
| 2013 |
Freeman LR, Zhang L, Nair A, Dasuri K, Francis J, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN. Obesity increases cerebrocortical reactive oxygen species and impairs brain function. Free Radical Biology & Medicine. 56: 226-33. PMID 23116605 DOI: 10.1016/J.Freeradbiomed.2012.08.577 |
0.344 |
|
| 2013 |
Dasuri K, Ebenezer P, Fernandez-Kim SO, Zhang L, Gao Z, Bruce-Keller AJ, Freeman LR, Keller JN. Role of physiological levels of 4-hydroxynonenal on adipocyte biology: implications for obesity and metabolic syndrome. Free Radical Research. 47: 8-19. PMID 23025469 DOI: 10.3109/10715762.2012.733003 |
0.318 |
|
| 2013 |
Dasuri K, Zhang L, Keller JN. Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis. Free Radical Biology & Medicine. 62: 170-85. PMID 23000246 DOI: 10.1016/J.Freeradbiomed.2012.09.016 |
0.414 |
|
| 2012 |
Freeman LR, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN. Mutant amyloid precursor protein differentially alters adipose biology under obesogenic and non-obesogenic conditions. Plos One. 7: e43193. PMID 22912823 DOI: 10.1371/Journal.Pone.0043193 |
0.308 |
|
| 2012 |
Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H, Keller JN, Murphy MP. Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression. Journal of Alzheimer's Disease : Jad. 32: 127-38. PMID 22766739 DOI: 10.3233/Jad-2012-120655 |
0.315 |
|
| 2012 |
Gupta S, Knight AG, Losso BY, Ingram DK, Keller JN, Bruce-Keller AJ. Brain injury caused by HIV protease inhibitors: role of lipodystrophy and insulin resistance. Antiviral Research. 95: 19-29. PMID 22580130 DOI: 10.1016/J.Antiviral.2012.04.010 |
0.323 |
|
| 2012 |
Gold BT, Keller JN. Preface for the special issue of imaging brain aging and neurodegenerative disease. Biochimica Et Biophysica Acta. 1822: 315-6. PMID 22265024 DOI: 10.1016/J.Bbadis.2012.01.001 |
0.333 |
|
| 2012 |
Freeman LR, Keller JN. Oxidative stress and cerebral endothelial cells: regulation of the blood-brain-barrier and antioxidant based interventions. Biochimica Et Biophysica Acta. 1822: 822-9. PMID 22206999 DOI: 10.1016/J.Bbadis.2011.12.009 |
0.354 |
|
| 2011 |
Dasuri K, Zhang L, Ebenezer P, Fernandez-Kim SO, Bruce-Keller AJ, Szweda LI, Keller JN. Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress. Free Radical Biology & Medicine. 51: 1727-35. PMID 21871954 DOI: 10.1016/J.Freeradbiomed.2011.08.001 |
0.352 |
|
| 2011 |
Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN. Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. Neurobiology of Disease. 44: 317-26. PMID 21798347 DOI: 10.1016/J.Nbd.2011.07.012 |
0.362 |
|
| 2011 |
Dasuri K, Ebenezer PJ, Uranga RM, Gavilán E, Zhang L, Fernandez-Kim SO, Bruce-Keller AJ, Keller JN. Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and TDP-43 regulation. Journal of Neuroscience Research. 89: 1471-7. PMID 21608013 DOI: 10.1002/Jnr.22677 |
0.358 |
|
| 2011 |
Zhang L, Ebenezer PJ, Dasuri K, Fernandez-Kim SO, Francis J, Mariappan N, Gao Z, Ye J, Bruce-Keller AJ, Keller JN. Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function. American Journal of Physiology. Endocrinology and Metabolism. 301: E599-607. PMID 21586698 DOI: 10.1152/Ajpendo.00059.2011 |
0.33 |
|
| 2010 |
Ebenezer PJ, Weidner AM, LeVine H, Markesbery WR, Murphy MP, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Gavilán E, Keller JN. Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress. Journal of Alzheimer's Disease : Jad. 22: 839-48. PMID 20858948 DOI: 10.3233/Jad-2010-101161 |
0.365 |
|
| 2010 |
Dasuri K, Ebenezer PJ, Zhang L, Fernandez-Kim SO, Uranga RM, Gavilán E, Di Blasio A, Keller JN. Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: implications for oxidative stress and insolubility of newly synthesized proteins. Free Radical Biology & Medicine. 49: 1290-7. PMID 20678570 DOI: 10.1016/J.Freeradbiomed.2010.07.014 |
0.408 |
|
| 2010 |
Morrison CD, Pistell PJ, Ingram DK, Johnson WD, Liu Y, Fernandez-Kim SO, White CL, Purpera MN, Uranga RM, Bruce-Keller AJ, Keller JN. High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling. Journal of Neurochemistry. 114: 1581-9. PMID 20557430 DOI: 10.1111/J.1471-4159.2010.06865.X |
0.378 |
|
| 2010 |
Uranga RM, Bruce-Keller AJ, Morrison CD, Fernandez-Kim SO, Ebenezer PJ, Zhang L, Dasuri K, Keller JN. Intersection between metabolic dysfunction, high fat diet consumption, and brain aging. Journal of Neurochemistry. 114: 344-61. PMID 20477933 DOI: 10.1111/J.1471-4159.2010.06803.X |
0.354 |
|
| 2010 |
Uranga RM, Keller JN. Diet and age interactions with regards to cholesterol regulation and brain pathogenesis. Current Gerontology and Geriatrics Research. 219683. PMID 20396385 DOI: 10.1155/2010/219683 |
0.381 |
|
| 2010 |
Bruce-Keller AJ, White CL, Gupta S, Knight AG, Pistell PJ, Ingram DK, Morrison CD, Keller JN. NOX activity in brain aging: exacerbation by high fat diet. Free Radical Biology & Medicine. 49: 22-30. PMID 20347034 DOI: 10.1016/J.Freeradbiomed.2010.03.006 |
0.351 |
|
| 2010 |
Dasuri K, Ebenezer P, Zhang L, Fernandez-Kim SO, Bruce-Keller AJ, Markesbery WR, Keller JN. Increased protein hydrophobicity in response to aging and Alzheimer disease. Free Radical Biology & Medicine. 48: 1330-7. PMID 20188163 DOI: 10.1016/J.Freeradbiomed.2010.02.012 |
0.436 |
|
| 2010 |
Pistell PJ, Morrison CD, Gupta S, Knight AG, Keller JN, Ingram DK, Bruce-Keller AJ. Cognitive impairment following high fat diet consumption is associated with brain inflammation. Journal of Neuroimmunology. 219: 25-32. PMID 20004026 DOI: 10.1016/J.Jneuroim.2009.11.010 |
0.301 |
|
| 2010 |
Bruce-Keller AJ, Gupta S, Parrino TE, Knight AG, Ebenezer PJ, Weidner AM, LeVine H, Keller JN, Markesbery WR. NOX activity is increased in mild cognitive impairment. Antioxidants & Redox Signaling. 12: 1371-82. PMID 19929442 DOI: 10.1089/Ars.2009.2823 |
0.354 |
|
| 2010 |
Zhang L, Ebenezer PJ, Dasuri K, Bruce-Keller AJ, Fernandez-Kim SO, Liu Y, Keller JN. Activation of PERK kinase in neural cells by proteasome inhibitor treatment. Journal of Neurochemistry. 112: 238-45. PMID 19860852 DOI: 10.1111/J.1471-4159.2009.06448.X |
0.32 |
|
| 2010 |
Amici M, Cecarini V, Cuccioloni M, Angeletti M, Barocci S, Rossi G, Fioretti E, Keller JN, Eleuteri AM. Interplay between 20S proteasomes and prion proteins in scrapie disease. Journal of Neuroscience Research. 88: 191-201. PMID 19658198 DOI: 10.1002/Jnr.22186 |
0.383 |
|
| 2009 |
Dasuri K, Zhang L, Ebenezer P, Liu Y, Fernandez-Kim SO, Keller JN. Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver. Mechanisms of Ageing and Development. 130: 777-83. PMID 19896962 DOI: 10.1016/J.Mad.2009.10.003 |
0.359 |
|
| 2009 |
White CL, Pistell PJ, Purpera MN, Gupta S, Fernandez-Kim SO, Hise TL, Keller JN, Ingram DK, Morrison CD, Bruce-Keller AJ. Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet. Neurobiology of Disease. 35: 3-13. PMID 19374947 DOI: 10.1016/J.Nbd.2009.04.002 |
0.301 |
|
| 2009 |
Turchan-Cholewo J, Dimayuga FO, Gupta S, Keller JN, Knapp PE, Hauser KF, Bruce-Keller AJ. Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation. Journal of Neurochemistry. 108: 202-15. PMID 19054280 DOI: 10.1111/J.1471-4159.2008.05756.X |
0.322 |
|
| 2009 |
Dasuri K, Nguyen A, Zhang L, Fernandez-Kim OS, Bruce-Keller AJ, Blalock BA, Cabo RD, Keller JN. Comparison of rat liver and brain proteasomes for oxidative stress-induced inactivation: Influence of ageing and dietary restriction. Free Radical Research. 43: 28-36. PMID 19048434 DOI: 10.1080/10715760802534812 |
0.388 |
|
| 2009 |
Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN. Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice. Journal of Neurochemistry. 108: 860-6. PMID 19046405 DOI: 10.1111/J.1471-4159.2008.05798.X |
0.372 |
|
| 2009 |
Zhang L, Bruce-Keller AJ, Dasuri K, Nguyen AT, Liu Y, Keller JN. Diet-induced metabolic disturbances as modulators of brain homeostasis. Biochimica Et Biophysica Acta. 1792: 417-22. PMID 18926905 DOI: 10.1016/J.Bbadis.2008.09.006 |
0.323 |
|
| 2009 |
Turchan-Cholewo J, Dimayuga VM, Gupta S, Gorospe RM, Keller JN, Bruce-Keller AJ. NADPH oxidase drives cytokine and neurotoxin release from microglia and macrophages in response to HIV-Tat. Antioxidants & Redox Signaling. 11: 193-204. PMID 18715150 DOI: 10.1089/Ars.2008.2097 |
0.312 |
|
| 2008 |
Bonfili L, Cecarini V, Amici M, Cuccioloni M, Angeletti M, Keller JN, Eleuteri AM. Natural polyphenols as proteasome modulators and their role as anti-cancer compounds. The Febs Journal. 275: 5512-26. PMID 18959740 DOI: 10.1111/J.1742-4658.2008.06696.X |
0.306 |
|
| 2008 |
Ansari MA, Keller JN, Scheff SW. Protective effect of Pycnogenol in human neuroblastoma SH-SY5Y cells following acrolein-induced cytotoxicity. Free Radical Biology & Medicine. 45: 1510-9. PMID 18822368 DOI: 10.1016/J.Freeradbiomed.2008.08.025 |
0.377 |
|
| 2008 |
Li F, Zhang L, Craddock J, Bruce-Keller AJ, Dasuri K, Nguyen A, Keller JN. Aging and dietary restriction effects on ubiquitination, sumoylation, and the proteasome in the heart. Mechanisms of Ageing and Development. 129: 515-21. PMID 18533226 DOI: 10.1016/J.Mad.2008.04.007 |
0.332 |
|
| 2008 |
Cecarini V, Bonfili L, Amici M, Angeletti M, Keller JN, Eleuteri AM. Amyloid peptides in different assembly states and related effects on isolated and cellular proteasomes. Brain Research. 1209: 8-18. PMID 18400214 DOI: 10.1016/J.Brainres.2008.03.003 |
0.377 |
|
| 2007 |
Zhang L, Li F, Dimayuga E, Craddock J, Keller JN. Effects of aging and dietary restriction on ubiquitination, sumoylation, and the proteasome in the spleen. Febs Letters. 581: 5543-7. PMID 17991438 DOI: 10.1016/J.Febslet.2007.10.054 |
0.367 |
|
| 2007 |
Ding Q, Dimayuga E, Keller JN. Oxidative stress alters neuronal RNA- and protein-synthesis: Implications for neural viability. Free Radical Research. 41: 903-10. PMID 17654047 DOI: 10.1080/10715760701416996 |
0.361 |
|
| 2007 |
Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H, Keller JN. Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiology of Disease. 27: 301-11. PMID 17651976 DOI: 10.1016/J.Nbd.2007.06.002 |
0.31 |
|
| 2007 |
Cecarini V, Ding Q, Keller JN. Oxidative inactivation of the proteasome in Alzheimer's disease. Free Radical Research. 41: 673-80. PMID 17516240 DOI: 10.1080/10715760701286159 |
0.339 |
|
| 2007 |
Butterfield DA, Reed TT, Perluigi M, De Marco C, Coccia R, Keller JN, Markesbery WR, Sultana R. Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease. Brain Research. 1148: 243-8. PMID 17395167 DOI: 10.1016/J.Brainres.2007.02.084 |
0.383 |
|
| 2007 |
Ding Q, Dimayuga E, Keller JN. Oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease. Current Alzheimer Research. 4: 73-9. PMID 17316168 DOI: 10.2174/156720507779939788 |
0.385 |
|
| 2007 |
Ding Q, Cecarini V, Keller JN. Interplay between protein synthesis and degradation in the CNS: physiological and pathological implications. Trends in Neurosciences. 30: 31-6. PMID 17126920 DOI: 10.1016/J.Tins.2006.11.003 |
0.358 |
|
| 2007 |
Cecarini V, Gee J, Fioretti E, Amici M, Angeletti M, Eleuteri AM, Keller JN. Protein oxidation and cellular homeostasis: Emphasis on metabolism. Biochimica Et Biophysica Acta. 1773: 93-104. PMID 17023064 DOI: 10.1016/J.Bbamcr.2006.08.039 |
0.767 |
|
| 2006 |
Keller JN. Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease. Journal of Biomedicine & Biotechnology. 2006: 12129. PMID 17047298 DOI: 10.1155/Jbb/2006/12129 |
0.397 |
|
| 2006 |
Gee JR, Ding Q, Keller JN. Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain. Biogerontology. 7: 69-79. PMID 16802110 DOI: 10.1007/S10522-005-6039-9 |
0.772 |
|
| 2006 |
Ding Q, Markesbery WR, Cecarini V, Keller JN. Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease. Neurochemical Research. 31: 705-10. PMID 16770743 DOI: 10.1007/S11064-006-9071-5 |
0.318 |
|
| 2006 |
Ding Q, Dimayuga E, Markesbery WR, Keller JN. Proteasome inhibition induces reversible impairments in protein synthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1055-63. PMID 16770004 DOI: 10.1096/Fj.05-5495Com |
0.374 |
|
| 2006 |
Ding Q, Dimayuga E, Keller JN. Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS. Antioxidants & Redox Signaling. 8: 163-72. PMID 16487050 DOI: 10.1089/Ars.2006.8.163 |
0.397 |
|
| 2006 |
Ding Q, Martin S, Dimayuga E, Bruce-Keller AJ, Keller JN. LMP2 knock-out mice have reduced proteasome activities and increased levels of oxidatively damaged proteins. Antioxidants & Redox Signaling. 8: 130-5. PMID 16487046 DOI: 10.1089/Ars.2006.8.130 |
0.426 |
|
| 2006 |
Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease. Journal of Neurochemistry. 96: 1322-35. PMID 16478525 DOI: 10.1111/J.1471-4159.2005.03647.X |
0.389 |
|
| 2006 |
Chen Q, Thorpe J, Dohmen JR, Li F, Keller JN. Ump1 extends yeast lifespan and enhances viability during oxidative stress: central role for the proteasome? Free Radical Biology & Medicine. 40: 120-6. PMID 16337885 DOI: 10.1016/J.Freeradbiomed.2005.08.048 |
0.396 |
|
| 2006 |
Keller JN. Age-related neuropathology, cognitive decline, and Alzheimer's disease. Ageing Research Reviews. 5: 1-13. PMID 16084778 DOI: 10.1016/J.Arr.2005.06.002 |
0.402 |
|
| 2005 |
Ding Q, Markesbery WR, Chen Q, Li F, Keller JN. Ribosome dysfunction is an early event in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9171-5. PMID 16207876 DOI: 10.1523/Jneurosci.3040-05.2005 |
0.366 |
|
| 2005 |
Smith RR, Dimayuga ER, Keller JN, Maragos WF. Enhanced toxicity to the catecholamine tyramine in polyglutamine transfected SH-SY5Y cells. Neurochemical Research. 30: 527-31. PMID 16076022 DOI: 10.1007/S11064-005-2687-Z |
0.34 |
|
| 2005 |
Chen Q, Thorpe J, Keller JN. Alpha-synuclein alters proteasome function, protein synthesis, and stationary phase viability. The Journal of Biological Chemistry. 280: 30009-17. PMID 15941712 DOI: 10.1074/Jbc.M501308200 |
0.325 |
|
| 2005 |
Gee JR, Ding Q, Keller JN. Modulation of apolipoprotein E and interleukin-1beta in the aging liver. Experimental Gerontology. 40: 409-15. PMID 15919593 DOI: 10.1016/J.Exger.2005.01.010 |
0.758 |
|
| 2005 |
Chen Q, Ding Q, Keller JN. The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration. Biogerontology. 6: 1-13. PMID 15834659 DOI: 10.1007/S10522-004-7379-6 |
0.386 |
|
| 2005 |
Keller JN, Schmitt FA, Scheff SW, Ding Q, Chen Q, Butterfield DA, Markesbery WR. Evidence of increased oxidative damage in subjects with mild cognitive impairment. Neurology. 64: 1152-6. PMID 15824339 DOI: 10.1212/01.Wnl.0000156156.13641.Ba |
0.378 |
|
| 2005 |
Gee JR, Keller JN. Astrocytes: regulation of brain homeostasis via apolipoprotein E. The International Journal of Biochemistry & Cell Biology. 37: 1145-50. PMID 15778078 DOI: 10.1016/J.Biocel.2004.10.004 |
0.768 |
|
| 2005 |
Chen Q, Ding Q, Thorpe J, Dohmen RJ, Keller JN. RNA interference toward UMP1 induces proteasome inhibition in Saccharomyces cerevisiae: evidence for protein oxidation and autophagic cell death. Free Radical Biology & Medicine. 38: 226-34. PMID 15607905 DOI: 10.1016/J.Freeradbiomed.2004.10.019 |
0.346 |
|
| 2005 |
Ding Q, Keller JN. Splice variants of the receptor for advanced glycosylation end products (RAGE) in human brain. Neuroscience Letters. 373: 67-72. PMID 15555779 DOI: 10.1016/J.Neulet.2004.09.059 |
0.336 |
|
| 2005 |
Chen Q, Thorpe J, Ding Q, El-Amouri IS, Keller JN. Proteasome synthesis and assembly are required for survival during stationary phase. Free Radical Biology & Medicine. 37: 859-68. PMID 15304258 DOI: 10.1016/J.Freeradbiomed.2004.05.025 |
0.373 |
|
| 2004 |
Ding Q, Dimayuga E, Markesbery WR, Keller JN. Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures. Journal of Neurochemistry. 91: 1211-8. PMID 15569264 DOI: 10.1111/J.1471-4159.2004.02802.X |
0.349 |
|
| 2004 |
Keller JN, Dimayuga E, Chen Q, Thorpe J, Gee J, Ding Q. Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. The International Journal of Biochemistry & Cell Biology. 36: 2376-91. PMID 15325579 DOI: 10.1016/J.Biocel.2004.05.003 |
0.793 |
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| 2004 |
Reed JL, Dimayuga FO, Davies LM, Keller JN, Bruce-Keller AJ. Estrogen increases proteasome activity in murine microglial cells. Neuroscience Letters. 367: 60-5. PMID 15308298 DOI: 10.1016/J.Neulet.2004.05.077 |
0.34 |
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| 2004 |
Martin S, Gee JR, Bruce-Keller AJ, Keller JN. Loss of an individual proteasome subunit alters motor function but not cognitive function or ambulation in mice. Neuroscience Letters. 357: 76-8. PMID 15036617 DOI: 10.1016/J.Neulet.2003.10.085 |
0.749 |
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| 2004 |
Ding Q, Bruce-Keller AJ, Chen Q, Keller JN. Analysis of gene expression in neural cells subject to chronic proteasome inhibition. Free Radical Biology & Medicine. 36: 445-55. PMID 14975447 DOI: 10.1016/J.Freeradbiomed.2003.10.025 |
0.32 |
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| 2004 |
Sullivan PG, Dragicevic NB, Deng JH, Bai Y, Dimayuga E, Ding Q, Chen Q, Bruce-Keller AJ, Keller JN. Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover. The Journal of Biological Chemistry. 279: 20699-707. PMID 14742431 DOI: 10.1074/Jbc.M313579200 |
0.331 |
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| 2003 |
Bruce-Keller AJ, Chauhan A, Dimayuga FO, Gee J, Keller JN, Nath A. Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8417-22. PMID 12968004 DOI: 10.1523/Jneurosci.23-23-08417.2003 |
0.755 |
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| 2003 |
Ding Q, Keller JN. Does proteasome inhibition play a role in mediating neuropathology and neuron death in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 5: 241-5. PMID 12897408 DOI: 10.3233/Jad-2003-5307 |
0.354 |
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| 2003 |
Ding Q, Dimayuga E, Martin S, Bruce-Keller AJ, Nukala V, Cuervo AM, Keller JN. Characterization of chronic low-level proteasome inhibition on neural homeostasis Journal of Neurochemistry. 86: 489-497. PMID 12871590 DOI: 10.1046/J.1471-4159.2003.01885.X |
0.364 |
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| 2003 |
Ding Q, Reinacker K, Dimayuga E, Nukala V, Drake J, Butterfield DA, Dunn JC, Martin S, Bruce-Keller AJ, Keller JN. Role of the proteasome in protein oxidation and neural viability following low-level oxidative stress Febs Letters. 546: 228-232. PMID 12832045 DOI: 10.1016/S0014-5793(03)00582-9 |
0.357 |
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| 2003 |
Dimayuga FO, Ding Q, Keller JN, Marchionni MA, Seroogy KB, Bruce-Keller AJ. The neuregulin GGF2 attenuates free radical release from activated microglial cells. Journal of Neuroimmunology. 136: 67-74. PMID 12620644 DOI: 10.1016/S0165-5728(03)00003-1 |
0.329 |
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| 2002 |
Keller JN, Gee J, Ding Q. The proteasome in brain aging. Ageing Research Reviews. 1: 279-93. PMID 12039443 DOI: 10.1016/S1568-1637(01)00006-X |
0.793 |
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| 2002 |
Gee J, Ding Q, Keller JN. Analysis of Werner's expression within the brain and primary neuronal culture. Brain Research. 940: 44-8. PMID 12020873 DOI: 10.1016/S0006-8993(02)02588-X |
0.765 |
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| 2002 |
Ding Q, Lewis JJ, Strum KM, Dimayuga E, Bruce-Keller AJ, Dunn JC, Keller JN. Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival. The Journal of Biological Chemistry. 277: 13935-42. PMID 11782460 DOI: 10.1074/Jbc.M107706200 |
0.356 |
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| 2002 |
Gee J, Ding Q, Keller J. Heat Shock Proteins and Proteasome Function in Neurodegeneration Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 2: 195-204. DOI: 10.2174/1568013023358852 |
0.742 |
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| 2001 |
Bruce-Keller AJ, Barger SW, Moss NI, Pham JT, Keller JN, Nath A. Pro-inflammatory and pro-oxidant properties of the HIV protein Tat in a microglial cell line: attenuation by 17 beta-estradiol. Journal of Neurochemistry. 78: 1315-24. PMID 11579140 DOI: 10.1046/J.1471-4159.2001.00511.X |
0.333 |
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| 2001 |
Ding Q, Keller JN. Proteasomes and proteasome inhibition in the central nervous system. Free Radical Biology & Medicine. 31: 574-84. PMID 11522442 DOI: 10.1016/S0891-5849(01)00635-9 |
0.384 |
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| 2001 |
Lauderback CM, Hackett JM, Huang FF, Keller JN, Szweda LI, Markesbery WR, Butterfield DA. The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42. Journal of Neurochemistry. 78: 413-6. PMID 11461977 DOI: 10.1046/J.1471-4159.2001.00451.X |
0.371 |
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| 2001 |
Ding Q, Keller JN. Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. Journal of Neurochemistry. 77: 1010-7. PMID 11359866 DOI: 10.1046/J.1471-4159.2001.00302.X |
0.357 |
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| 2001 |
Lauderback CM, Hackett JM, Keller JN, Varadarajan S, Szweda L, Kindy M, Markesbery WR, Butterfield DA. Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): implications for Alzheimer's disease. Biochemistry. 40: 2548-54. PMID 11327877 DOI: 10.1021/Bi002312K |
0.386 |
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| 2001 |
Keller JN, Glazner GW. Mitochondrial oxidative stress and metabolic alterations in neurodegenerative disorders Advances in Cell Aging and Gerontology. 7: 205-237. DOI: 10.1016/S1566-3124(01)07020-1 |
0.316 |
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| 2000 |
Keller JN, Huang FF, Zhu H, Yu J, Ho YS, Kindy TS. Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 20: 1467-73. PMID 11043909 DOI: 10.1097/00004647-200010000-00008 |
0.33 |
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| 2000 |
Bruce-Keller AJ, Keeling JL, Keller JN, Huang FF, Camondola S, Mattson MP. Antiinflammatory effects of estrogen on microglial activation. Endocrinology. 141: 3646-56. PMID 11014219 DOI: 10.1210/Endo.141.10.7693 |
0.32 |
|
| 2000 |
Keller JN, Markesbery WR. Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death. Journal of Neuroscience Research. 61: 436-42. PMID 10931530 DOI: 10.1002/1097-4547(20000815)61:4<436::Aid-Jnr10>3.0.Co;2-Z |
0.306 |
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| 2000 |
Keller JN, Huang FF, Markesbery WR. Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience. 98: 149-56. PMID 10858621 DOI: 10.1016/S0306-4522(00)00067-1 |
0.353 |
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| 2000 |
Keller JN, Hanni KB, Markesbery WR. Impaired proteasome function in Alzheimer's disease. Journal of Neurochemistry. 75: 436-9. PMID 10854289 DOI: 10.1046/J.1471-4159.2000.0750436.X |
0.362 |
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| 2000 |
Steiner MR, Holtsberg FW, Keller JN, Mattson MP, Steiner SM. Lysophosphatidic acid induction of neuronal apoptosis and necrosis. Annals of the New York Academy of Sciences. 905: 132-41. PMID 10818449 DOI: 10.1111/J.1749-6632.2000.Tb06545.X |
0.31 |
|
| 2000 |
Keller JN, Lauderback CM, Butterfield DA, Kindy MS, Yu J, Markesbery WR. Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice. Journal of Neurochemistry. 74: 1579-86. PMID 10737615 DOI: 10.1046/J.1471-4159.2000.0741579.X |
0.345 |
|
| 2000 |
Keller JN, Hanni KB, Markesbery WR. Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mechanisms of Ageing and Development. 113: 61-70. PMID 10708250 DOI: 10.1016/S0047-6374(99)00101-3 |
0.389 |
|
| 2000 |
Keller JN, Hanni KB, Kindy MS. Oxidized high-density lipoprotein induces neuron death Experimental Neurology. 161: 621-630. PMID 10686081 DOI: 10.1006/Exnr.1999.7276 |
0.358 |
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| 2000 |
Lauderback CM, Keller JN, Varadarajan S, Kindy M, Markesbery WR, Butterfield A. Synaptosomes from apolipoprotein E-deficient mice are vulnerable to oxidative insult from Aβ Neurobiology of Aging. 21: 154. DOI: 10.1016/S0197-4580(00)82031-X |
0.3 |
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| 1999 |
Keller JN, Hanni KB, Markesbery WR. 4-hydroxynonenal increases neuronal susceptibility to oxidative stress. Journal of Neuroscience Research. 58: 823-30. PMID 10583913 DOI: 10.1002/(Sici)1097-4547(19991215)58:6<823::Aid-Jnr9>3.0.Co;2-T |
0.355 |
|
| 1999 |
Bruce-Keller AJ, Geddes JW, Knapp PE, McFall RW, Keller JN, Holtsberg FW, Parthasarathy S, Steiner SM, Mattson MP. Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD. Journal of Neuroimmunology. 93: 53-71. PMID 10378869 DOI: 10.1016/S0165-5728(98)00190-8 |
0.3 |
|
| 1999 |
Keller JN, Hanni KB, Gabbita SP, Friebe V, Mattson MP, Kindy MS. Oxidized lipoproteins increase reactive oxygen species formation in microglia and astrocyte cell lines Brain Research. 830: 10-15. PMID 10350554 DOI: 10.1016/S0006-8993(99)01272-X |
0.36 |
|
| 1999 |
Keller JN, Hanni KB, Markesbery WR. Oxidized low-density lipoprotein induces neuronal death: implications for calcium, reactive oxygen species, and caspases. Journal of Neurochemistry. 72: 2601-9. PMID 10349872 DOI: 10.1046/J.1471-4159.1999.0722601.X |
0.368 |
|
| 1999 |
Keller JN, Hanni KB, Pedersen WA, Cashman NR, Mattson MP, Gabbita SP, Friebe V, Markesbery WR. Opposing actions of native and oxidized lipoprotein on motor neuron-like cells. Experimental Neurology. 157: 202-10. PMID 10222123 DOI: 10.1006/Exnr.1999.7043 |
0.333 |
|
| 1998 |
Keller JN, Hanni KB, Mattson MP, Markesbery WR. Cyclic nucleotides attenuate lipid peroxidation-mediated neuron toxicity. Neuroreport. 9: 3731-4. PMID 9858387 DOI: 10.1097/00001756-199811160-00029 |
0.335 |
|
| 1998 |
Pedersen WA, Fu W, Keller JN, Markesbery WR, Appel S, Smith RG, Kasarskis E, Mattson MP. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Annals of Neurology. 44: 819-24. PMID 9818940 DOI: 10.1002/Ana.410440518 |
0.32 |
|
| 1998 |
Sullivan PG, Keller JN, Mattson MP, Scheff SW. Traumatic brain injury alters synaptic homeostasis: implications for impaired mitochondrial and transport function. Journal of Neurotrauma. 15: 789-98. PMID 9814635 DOI: 10.1089/Neu.1998.15.789 |
0.3 |
|
| 1998 |
Holtsberg FW, Steiner MR, Bruce-Keller AJ, Keller JN, Mattson MP, Moyers JC, Steiner SM. Lysophosphatidic acid and apoptosis of nerve growth factor-differentiated PC12 cells. Journal of Neuroscience Research. 53: 685-96. PMID 9753197 DOI: 10.1002/(Sici)1097-4547(19980915)53:6<685::Aid-Jnr7>3.0.Co;2-1 |
0.332 |
|
| 1998 |
Blanc EM, Keller JN, Fernandez S, Mattson MP. 4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes. Glia. 22: 149-60. PMID 9537835 DOI: 10.1002/(Sici)1098-1136(199802)22:2<149::Aid-Glia6>3.0.Co;2-2 |
0.323 |
|
| 1998 |
Keller JN, Kindy MS, Holtsberg FW, St Clair DK, Yen HC, Germeyer A, Steiner SM, Bruce-Keller AJ, Hutchins JB, Mattson MP. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 687-97. PMID 9425011 DOI: 10.1523/Jneurosci.18-02-00687.1998 |
0.355 |
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| 1998 |
Holtsberg FW, Steiner MR, Keller JN, Mark RJ, Mattson MP, Steiner SM. Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons. Journal of Neurochemistry. 70: 66-76. PMID 9422348 DOI: 10.1046/J.1471-4159.1998.70010066.X |
0.312 |
|
| 1998 |
Keller JN, Germeyer A, Begley JG, Mattson MP. 17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron. Journal of Neuroscience Research. 50: 522-30. PMID 9404714 DOI: 10.1002/(Sici)1097-4547(19971115)50:4<522::Aid-Jnr3>3.0.Co;2-G |
0.303 |
|
| 1998 |
Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP. Increased Sensitivity to Mitochondrial Toxin-Induced Apoptosis in Neural Cells Expressing Mutant Presenilin-1 Is Linked to Perturbed Calcium Homeostasis and Enhanced Oxyradical Production The Journal of Neuroscience. 18: 4439-4450. DOI: 10.1523/Jneurosci.18-12-04439.1998 |
0.321 |
|
| 1997 |
Subramaniam R, Roediger F, Jordan B, Mattson MP, Keller JN, Waeg G, Butterfield DA. The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins. Journal of Neurochemistry. 69: 1161-9. PMID 9282939 DOI: 10.1046/J.1471-4159.1997.69031161.X |
0.333 |
|
| 1997 |
Keller JN, Steiner MR, Holtsberg FW, Mattson MP, Steiner SM. Lysophosphatidic acid-induced proliferation-related signals in astrocytes. Journal of Neurochemistry. 69: 1073-84. PMID 9282930 DOI: 10.1046/J.1471-4159.1997.69031073.X |
0.302 |
|
| 1997 |
Keller JN, Mark RJ, Bruce AJ, Blanc E, Rothstein JD, Uchida K, Waeg G, Mattson MP. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience. 80: 685-96. PMID 9276486 DOI: 10.1016/S0306-4522(97)00065-1 |
0.367 |
|
| 1997 |
Keller JN, Pang Z, Geddes JW, Begley JG, Germeyer A, Waeg G, Mattson MP. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal. Journal of Neurochemistry. 69: 273-84. PMID 9202320 DOI: 10.1046/J.1471-4159.1997.69010273.X |
0.345 |
|
| 1997 |
Mark RJ, Keller JN, Kruman I, Mattson MP. Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons. Brain Research. 756: 205-14. PMID 9187334 DOI: 10.1016/S0006-8993(97)00196-0 |
0.36 |
|
| 1994 |
Geddes JW, Bondada V, Keller JN. Effects of intrahippocampal colchicine administration on the levels and localization of microtubule-associated proteins, tau and MAP2. Brain Research. 633: 1-8. PMID 7511033 DOI: 10.1016/0006-8993(94)91515-6 |
0.302 |
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