Priscilla A. Schaffer - Publications

Affiliations: 
1969-1976 Virology and Epidemiology Baylor College of Medicine, Houston, TX 
 1976-2007 Harvard University, Cambridge, MA, United States 
 2007-2009 Molecular and Cellular Biology University of Arizona, Tucson, AZ 
Area:
Microbiology Biology, Molecular Biology
Website:
https://doi.org/10.1128/JVI.00781-10

157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Gelev V, Zabolotny JM, Lange M, Hiromura M, Yoo SW, Orlando JS, Kushnir A, Horikoshi N, Paquet E, Bachvarov D, Schaffer PA, Usheva A. A new paradigm for transcription factor TFIIB functionality. Scientific Reports. 4: 3664. PMID 24441171 DOI: 10.1038/Srep03664  0.764
2011 Mostafa HH, Thompson TW, Kushnir AS, Haenchen SD, Bayless AM, Hilliard JG, Link MA, Pitcher LA, Loveday E, Schaffer PA, Davido DJ. Herpes simplex virus 1 ICP0 phosphorylation site mutants are attenuated for viral replication and impaired for explant-induced reactivation. Journal of Virology. 85: 12631-7. PMID 21937654 DOI: 10.1128/Jvi.05661-11  0.805
2010 Kushnir AS, Davido DJ, Schaffer PA. Role of nuclear factor Y in stress-induced activation of the herpes simplex virus type 1 ICP0 promoter. Journal of Virology. 84: 188-200. PMID 19828605 DOI: 10.1128/Jvi.01377-09  0.785
2009 Bowman JJ, Schaffer PA. Origin of expression of the herpes simplex virus type 1 protein U(S)1.5. Journal of Virology. 83: 9183-94. PMID 19570862 DOI: 10.1128/Jvi.00984-09  0.461
2009 Bowman JJ, Orlando JS, Davido DJ, Kushnir AS, Schaffer PA. Transient expression of herpes simplex virus type 1 ICP22 represses viral promoter activity and complements the replication of an ICP22 null virus. Journal of Virology. 83: 8733-43. PMID 19535441 DOI: 10.1128/Jvi.00810-09  0.826
2008 Bringhurst RM, Dominguez AA, Schaffer PA. Glutamine deprivation causes enhanced plating efficiency of a herpes simplex virus type 1 ICP0-null mutant. Journal of Virology. 82: 11472-5. PMID 18768961 DOI: 10.1128/Jvi.01086-08  0.58
2008 Boutell C, Everett R, Hilliard J, Schaffer P, Orr A, Davido D. Herpes simplex virus type 1 ICP0 phosphorylation mutants impair the E3 ubiquitin ligase activity of ICP0 in a cell type-dependent manner. Journal of Virology. 82: 10647-56. PMID 18715910 DOI: 10.1128/Jvi.01063-08  0.574
2007 Link MA, Schaffer PA. Herpes simplex virus type 1 C-terminal variants of the origin binding protein (OBP), OBPC-1 and OBPC-2, cooperatively regulate viral DNA levels in vitro, and OBPC-2 affects mortality in mice. Journal of Virology. 81: 10699-711. PMID 17634223 DOI: 10.1128/Jvi.01213-07  0.81
2007 Link MA, Silva LA, Schaffer PA. Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication. Journal of Virology. 81: 9175-82. PMID 17553869 DOI: 10.1128/Jvi.00676-07  0.809
2007 Balliet JW, Kushnir AS, Schaffer PA. Construction and characterization of a herpes simplex virus type I recombinant expressing green fluorescent protein: acute phase replication and reactivation in mice. Virology. 361: 372-83. PMID 17207829 DOI: 10.1016/J.Virol.2006.11.022  0.824
2007 Melroe GT, Silva L, Schaffer PA, Knipe DM. Recruitment of activated IRF-3 and CBP/p300 to herpes simplex virus ICP0 nuclear foci: Potential role in blocking IFN-beta induction. Virology. 360: 305-21. PMID 17126870 DOI: 10.1016/J.Virol.2006.10.028  0.493
2006 Orlando JS, Balliet JW, Kushnir AS, Astor TL, Kosz-Vnenchak M, Rice SA, Knipe DM, Schaffer PA. ICP22 is required for wild-type composition and infectivity of herpes simplex virus type 1 virions. Journal of Virology. 80: 9381-90. PMID 16973544 DOI: 10.1128/Jvi.01061-06  0.823
2006 Bringhurst RM, Schaffer PA. Cellular stress rather than stage of the cell cycle enhances the replication and plating efficiencies of herpes simplex virus type 1 ICP0- viruses. Journal of Virology. 80: 4528-37. PMID 16611913 DOI: 10.1128/Jvi.80.9.4528-4537.2006  0.5
2006 Orlando JS, Astor TL, Rundle SA, Schaffer PA. The products of the herpes simplex virus type 1 immediate-early US1/US1.5 genes downregulate levels of S-phase-specific cyclins and facilitate virus replication in S-phase Vero cells. Journal of Virology. 80: 4005-16. PMID 16571817 DOI: 10.1128/Jvi.80.8.4005-4016.2006  0.493
2006 Balliet JW, Schaffer PA. Point mutations in herpes simplex virus type 1 oriL, but not in oriS, reduce pathogenesis during acute infection of mice and impair reactivation from latency. Journal of Virology. 80: 440-50. PMID 16352568 DOI: 10.1128/Jvi.80.1.440-450.2006  0.625
2005 Balliet JW, Min JC, Cabatingan MS, Schaffer PA. Site-directed mutagenesis of large DNA palindromes: construction and in vitro characterization of herpes simplex virus type 1 mutants containing point mutations that eliminate the oriL or oriS initiation function. Journal of Virology. 79: 12783-97. PMID 16188981 DOI: 10.1128/Jvi.79.20.12783-12797.2005  0.545
2005 Davido DJ, von Zagorski WF, Lane WS, Schaffer PA. Phosphorylation site mutations affect herpes simplex virus type 1 ICP0 function. Journal of Virology. 79: 1232-43. PMID 15613350 DOI: 10.1128/Jvi.79.2.1232-1243.2005  0.47
2003 Davido DJ, Von Zagorski WF, Maul GG, Schaffer PA. The differential requirement for cyclin-dependent kinase activities distinguishes two functions of herpes simplex virus type 1 ICP0. Journal of Virology. 77: 12603-16. PMID 14610183 DOI: 10.1128/Jvi.77.23.12603-12616.2003  0.585
2002 Schang LM, Bantly A, Knockaert M, Shaheen F, Meijer L, Malim MH, Gray NS, Schaffer PA. Pharmacological cyclin-dependent kinase inhibitors inhibit replication of wild-type and drug-resistant strains of herpes simplex virus and human immunodeficiency virus type 1 by targeting cellular, not viral, proteins. Journal of Virology. 76: 7874-82. PMID 12097601 DOI: 10.1128/Jvi.76.15.7874-7882.2002  0.544
2002 Schang LM, Bantly A, Schaffer PA. Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4. Journal of Virology. 76: 7724-35. PMID 12097586 DOI: 10.1128/Jvi.76.15.7724-7735.2002  0.378
2002 Chen SH, Lee LY, Garber DA, Schaffer PA, Knipe DM, Coen DM. Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus. Journal of Virology. 76: 4764-72. PMID 11967293 DOI: 10.1128/Jvi.76.10.4764-4772.2002  0.515
2002 Crumpacker CS, Schaffer PA. New anti-HSV therapeutics target the helicase-primase complex. Nature Medicine. 8: 327-8. PMID 11927930 DOI: 10.1038/Nm0402-327  0.454
2002 Davido DJ, Leib DA, Schaffer PA. The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0. Journal of Virology. 76: 1077-88. PMID 11773384 DOI: 10.1128/Jvi.76.3.1077-1088.2002  0.736
2001 Isler JA, Schaffer PA. Origin binding protein-containing protein-DNA complex formation at herpes simplex virus type 1 oriS: role in oriS-dependent DNA replication. Journal of Virology. 75: 6808-16. PMID 11435559 DOI: 10.1128/Jvi.75.15.6808-6816.2001  0.515
2001 Halford WP, Kemp CD, Isler JA, Davido DJ, Schaffer PA. ICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trigeminal ganglion cells. Journal of Virology. 75: 6143-53. PMID 11390616 DOI: 10.1128/Jvi.75.13.6143-6153.2001  0.585
2001 Halford WP, Schaffer PA. ICP0 is required for efficient reactivation of herpes simplex virus type 1 from neuronal latency Journal of Virology. 75: 3240-3249. PMID 11238850 DOI: 10.1128/Jvi.75.7.3240-3249.2001  0.588
2001 Isler JA, Schaffer PA. Phosphorylation of the herpes simplex virus type 1 origin binding protein. Journal of Virology. 75: 628-37. PMID 11134276 DOI: 10.1128/Jvi.75.2.628-637.2001  0.612
2000 Chen SH, Garber DA, Schaffer PA, Knipe DM, Coen DM. Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation Virology. 278: 207-216. PMID 11112495 DOI: 10.1006/Viro.2000.0643  0.583
2000 Halford WP, Schaffer PA. Optimized viral dose and transient immunosuppression enable herpes simplex virus ICP0-null mutants to establish wild-type levels of latency in vivo Journal of Virology. 74: 5957-5967. PMID 10846077 DOI: 10.1128/Jvi.74.13.5957-5967.2000  0.556
2000 Schang LM, Hwang GJ, Dynlacht BD, Speicher DW, Bantly A, Schaffer PA, Shilatifard A, Ge H, Shiekhattar R. Human PC4 is a substrate-specific inhibitor of RNA polymerase II phosphorylation. The Journal of Biological Chemistry. 275: 6071-4. PMID 10692395 DOI: 10.1074/Jbc.275.9.6071  0.307
2000 Schang LM, Rosenberg A, Schaffer PA. Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins Journal of Virology. 74: 2107-2120. PMID 10666240 DOI: 10.1128/Jvi.74.5.2107-2120.2000  0.571
1999 Jordan R, Schang L, Schaffer PA. Transactivation of herpes simplex virus type 1 immediate-early gene expression by virion-associated factors is blocked by an inhibitor of cyclin-dependent protein kinases. Journal of Virology. 73: 8843-7. PMID 10482641 DOI: 10.1128/Jvi.73.10.8843-8847.1999  0.577
1999 Long MC, Leong V, Schaffer PA, Spencer CA, Rice SA. ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II. Journal of Virology. 73: 5593-604. PMID 10364308 DOI: 10.1128/Jvi.73.7.5593-5604.1999  0.579
1999 Schang LM, Rosenberg A, Schaffer PA. Transcription of herpes simplex virus immediate-early and early genes is inhibited by roscovitine, an inhibitor specific for cellular cyclin-dependent kinases Journal of Virology. 73: 2161-2172. PMID 9971799 DOI: 10.1128/Jvi.73.3.2161-2172.1999  0.561
1998 Dunkel EC, Scheer DI, Zhu Q, Whitley RJ, Schaffer PA, Pavan-Langston D. Retraction: A rabbit model for human cytomeglovirus--induced chorioretinal disease (J Infect Dis 1993;168:336-44) The Journal of Infectious Diseases. 177: 1778. PMID 9634358 DOI: 10.1086/515332  0.303
1998 Schang LM, Phillips J, Schaffer PA. Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription Journal of Virology. 72: 5626-5637. PMID 9621021 DOI: 10.1128/Jvi.72.7.5626-5637.1998  0.5
1998 Jordan R, Pepe J, Schaffer PA. Characterization of a nerve growth factor-inducible cellular activity that enhances herpes simplex virus type 1 gene expression and replication of an ICP0 null mutant in cells of neural lineage Journal of Virology. 72: 5373-5382. PMID 9620991 DOI: 10.1128/Jvi.72.7.5373-5382.1998  0.531
1998 Lee LY, Schaffer PA. A virus with a mutation in the ICP4-binding site in the L/ST promoter of herpes simplex virus type 1, but not a virus with a mutation in open reading frame P, exhibits cell-type-specific expression of gamma(1)34.5 transcripts and latency-associated transcripts. Journal of Virology. 72: 4250-64. PMID 9557715 DOI: 10.1128/Jvi.72.5.4250-4264.1998  0.533
1998 Nguyen-Huynh AT, Schaffer PA. Cellular transcription factors enhance herpes simplex virus type 1 oriS-dependent DNA replication. Journal of Virology. 72: 3635-45. PMID 9557644 DOI: 10.1128/Jvi.72.5.3635-3645.1998  0.494
1998 Zhao ZS, Granucci F, Yeh L, Schaffer PA, Cantor H. Molecular mimicry by herpes simplex virus-type 1: autoimmune disease after viral infection. Science (New York, N.Y.). 279: 1344-7. PMID 9478893 DOI: 10.1126/Science.279.5355.1344  0.54
1997 Jordan R, Schaffer PA. Activation of gene expression by herpes simplex virus type 1 ICP0 occurs at the level of mRNA synthesis. Journal of Virology. 71: 6850-62. PMID 9261410  0.409
1997 Garber DA, Schaffer PA, Knipe DM. A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1 Journal of Virology. 71: 5885-5893. PMID 9223478 DOI: 10.1128/Jvi.71.8.5885-5893.1997  0.502
1997 Chen SH, Kramer MF, Schaffer PA, Coen DM. A viral function represses accumulation of transcripts from productive- cycle genes in mouse ganglia latently infected with herpes simplex virus Journal of Virology. 71: 5878-5884. PMID 9223477 DOI: 10.1128/Jvi.71.8.5878-5884.1997  0.558
1997 Hardwicke MA, Schaffer PA. Differential effects of nerve growth factor and dexamethasone on herpes simplex virus type 1 oriL- and oriS-dependent DNA replication in PC12 cells. Journal of Virology. 71: 3580-7. PMID 9094630  0.406
1996 Frazier DP, Cox D, Godshalk EM, Schaffer PA. Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells Journal of Virology. 70: 7433-7444. PMID 8892861  0.316
1996 Frazier DP, Cox D, Godshalk EM, Schaffer PA. The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells Journal of Virology. 70: 7424-7432. PMID 8892860  0.337
1996 Baradaran K, Hardwicke MA, Dabrowski CE, Schaffer PA. Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC. Journal of Virology. 70: 5673-9. PMID 8764087  0.447
1996 Zhu Z, DeLuca NA, Schaffer PA. Overexpression of the herpes simplex virus type 1 immediate-early regulatory protein, ICP27, is responsible for the aberrant localization of ICP0 and mutant forms of ICP4 in ICP4 mutant virus-infected cells Journal of Virology. 70: 5346-5356. PMID 8764045  0.738
1996 Wu N, Watkins SC, Schaffer PA, DeLuca NA. Prolonged gene expression and cell survival after infection by a herpes simplex virus mutant defective in the immediate-early genes encoding ICP4, ICP27, and ICP22 Journal of Virology. 70: 6358-6369. PMID 8709264  0.703
1996 Frazier DP, Cox D, Godshalk EM, Schaffer PA. Identification of cis-acting sequences in the promoter of the herpes simplex virus type 1 latency-associated transcripts required for activation by nerve growth factor and sodium butyrate in PC12 cells. Journal of Virology. 70: 7433-7444. DOI: 10.1128/jvi.70.11.7433-7444.1996  0.328
1996 Frazier DP, Cox D, Godshalk EM, Schaffer PA. The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells. Journal of Virology. 70: 7424-7432. DOI: 10.1128/jvi.70.11.7424-7432.1996  0.313
1995 Zhu Z, Schaffer PA. Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27. Journal of Virology. 69: 49-59. PMID 7983745  0.569
1995 Hardwicke MA, Schaffer PA. Cloning and characterization of herpes simplex virus type 1 oriL: comparison of replication and protein-DNA complex formation by oriL and oriS. Journal of Virology. 69: 1377-88. PMID 7853470  0.431
1995 Yao F, Schaffer PA. An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1 Journal of Virology. 69: 6249-6258. PMID 7666525  0.475
1995 Rice SA, Long MC, Lam V, Schaffer PA, Spencer CA. Herpes simplex virus immediate-early protein ICP22 is required for viral modification of host RNA polymerase II and establishment of the normal viral transcription program. Journal of Virology. 69: 5550-9. PMID 7637000  0.522
1995 Zhu Z, Schaffer PA. Intracellular localization of the herpes simplex virus type 1 major transcriptional regulatory protein, ICP4, is affected by ICP27. Journal of Virology. 69: 49-59. DOI: 10.1128/jvi.69.1.49-59.1995  0.472
1994 Fourel I, Saputelli J, Schaffer P, Mason WS. The carbocyclic analog of 2'-deoxyguanosine induces a prolonged inhibition of duck hepatitis B virus DNA synthesis in primary hepatocyte cultures and in the liver. Journal of Virology. 68: 1059-1065. PMID 8289335 DOI: 10.1128/Jvi.68.2.1059-1065.1994  0.529
1994 Baradaran K, Dabrowski CE, Schaffer PA. Transcriptional analysis of the region of the herpes simplex virus type 1 genome containing the UL8, UL9, and UL10 genes and identification of a novel delayed-early gene product, OBPC. Journal of Virology. 68: 4251-61. PMID 8207800  0.366
1994 Zhu Z, Cai W, Schaffer PA. Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins: ICP4 and ICP27 affect the intracellular localization of ICP0. Journal of Virology. 68: 3027-40. PMID 8151771  0.535
1994 Dabrowski CE, Carmillo PJ, Schaffer PA. Cellular protein interactions with herpes simplex virus type 1 oriS. Molecular and Cellular Biology. 14: 2545-55. PMID 8139557 DOI: 10.1128/mcb.14.4.2545  0.3
1994 Fourel I, Cullen JM, Saputelli J, Aldrich CE, Schaffer P, Averett DR, Pugh J, Mason WS. Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks. Journal of Virology. 68: 8321-30. PMID 7966625 DOI: 10.1128/Jvi.68.12.8321-8330.1994  0.417
1994 Yao F, Schaffer PA. Physical interaction between the herpes simplex virus type 1 immediate- early regulatory proteins ICP0 and ICP4 Journal of Virology. 68: 8158-8168. PMID 7966607  0.408
1994 Ralph WM, Cabatingan MS, Schaffer PA. Induction of herpes simplex virus type 1 immediate-early gene expression by a cellular activity expressed in Vero and NB41A3 cells after growth arrest-release. Journal of Virology. 68: 6871-82. PMID 7933067  0.427
1994 Zhu Z, Cai W, Schaffer PA. Cooperativity among herpes simplex virus type 1 immediate-early regulatory proteins: ICP4 and ICP27 affect the intracellular localization of ICP0. Journal of Virology. 68: 3027-3040. DOI: 10.1128/jvi.68.5.3027-3040.1994  0.471
1994 Mason WS, Cullen J, Saputelli J, Wu T‐, Liu C, London WT, Lustbader E, Schaffer P, O'Connell AP, Fourel I, Aldrich CE, Jilbert AR. Characterization of the antiviral effects of 2′ carbodeoxyguanosine in ducks chronically infected with duck hepatitis B virus Hepatology. 19: 398-411. DOI: 10.1002/Hep.1840190219  0.508
1993 Cai W, Astor TL, Liptak LM, Cho C, Coen DM, Schaffer PA. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency Journal of Virology. 67: 7501-7512. PMID 8230470 DOI: 10.1128/Jvi.67.12.7501-7512.1993  0.615
1993 Yeh L, Schaffer PA. A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. Journal of Virology. 67: 7373-82. PMID 7901428  0.456
1992 Golden MP, Kim S, Hammer SM, Ladd EA, Schaffer PA, DeLuca N, Albrecht MA. Activation of human immunodeficiency virus by herpes simplex virus Journal of Infectious Diseases. 166: 494-499. PMID 1354237 DOI: 10.1093/Infdis/166.3.494  0.688
1992 Cai W, Schaffer PA. Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells Journal of Virology. 66: 2904-2915. PMID 1313909  0.573
1992 Polvino-Bodnar M, Schaffer PA. DNA binding activity is required for EBNA 1-dependent transcriptional activation and DNA replication. Virology. 187: 591-603. PMID 1312270 DOI: 10.1016/0042-6822(92)90461-W  0.448
1992 Huang Q, Vonsattel JP, Schaffer PA, Martuza RL, Breakefield XO, DiFiglia M. Introduction of a foreign gene (Escherichia coli lacZ) into rat neostriatal neurons using herpes simplex virus mutants: a light and electron microscopic study. Experimental Neurology. 115: 303-16. PMID 1311266 DOI: 10.1016/0014-4886(92)90196-W  0.468
1991 Dabrowski CE, Schaffer PA. Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins. Journal of Virology. 65: 3140-50. PMID 1851874  0.331
1991 Wong SW, Schaffer PA. Elements in the Transcriptional Regulatory Region Flanking Herpes Simplex Virus Type 1 oriS Stimulate Origin Function Journal of Virology. 65: 2601-2611. PMID 1850034 DOI: 10.1128/Jvi.65.5.2601-2611.1991  0.497
1991 Leib DA, Nadeau KC, Rundle SA, Schaffer PA. The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Proceedings of the National Academy of Sciences of the United States of America. 88: 48-52. PMID 1846042 DOI: 10.1073/Pnas.88.1.48  0.512
1991 Cai W, Schaffer PA. A cellular function can enhance gene expression and plating efficiency of a mutant defective in the gene for ICP0, a transactivating protein of herpes simplex virus type 1 Journal of Virology. 65: 4078-4090. PMID 1649316  0.448
1990 Chiocca EA, Choi BB, Cai WZ, DeLuca NA, Schaffer PA, DiFiglia M, Breakefield XO, Martuza RL. Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. The New Biologist. 2: 739-46. PMID 2178004  0.713
1990 Goodrich LD, Schaffer PA, Dorsky DI, Crumpacker CS, Parris DS. Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis. Journal of Virology. 64: 5738-49. PMID 2173766 DOI: 10.1128/Jvi.64.12.5738-5749.1990  0.588
1990 Leib DA, Ruffner KL, Hildebrand C, Schaffer PA, Wright GE, Coen DM. Specific inhibitors of herpes simplex virus thymidine kinase diminish reactivation of latent virus from explanted murine ganglia. Antimicrobial Agents and Chemotherapy. 34: 1285-6. PMID 2168150 DOI: 10.1128/Aac.34.6.1285  0.499
1990 McMahan L, Schaffer PA. The repressing and enhancing functions of the herpes simplex virus regulatory protein ICP27 map to C-terminal regions and are required to modulate viral gene expression very early in infection. Journal of Virology. 64: 3471-85. PMID 2161950  0.479
1989 Jacobson JG, Leib DA, Goldstein DJ, Bogard CL, Schaffer PA, Weller SK, Coen DM. A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells. Virology. 173: 276-83. PMID 2554573 DOI: 10.1016/0042-6822(89)90244-4  0.591
1989 Cai W, Schaffer PA. Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA Journal of Virology. 63: 4579-4589. PMID 2552142  0.608
1989 Coen DM, Kosz-Vnenchak M, Jacobson JG, Leib DA, Bogard CL, Schaffer PA, Tyler KL, Knipe DM. Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate. Proceedings of the National Academy of Sciences of the United States of America. 86: 4736-40. PMID 2543985 DOI: 10.1073/Pnas.86.12.4736  0.605
1989 Leib DA, Bogard CL, Kosz-Vnenchak M, Hicks KA, Coen DM, Knipe DM, Schaffer PA. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency. Journal of Virology. 63: 2893-900. PMID 2542601 DOI: 10.1128/Jvi.63.7.2893-2900.1989  0.638
1989 Smith CA, Marchetti ME, Edmonson P, Schaffer PA. Herpes simplex virus type 2 mutants with deletions in the intergenic region between ICP4 and ICP22/47: identification of nonessential cis-acting elements in the context of the viral genome. Journal of Virology. 63: 2036-47. PMID 2539500  0.449
1989 Leib DA, Coen DM, Bogard CL, Hicks KA, Yager DR, Knipe DM, Tyler KL, Schaffer PA. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency. Journal of Virology. 63: 759-68. PMID 2536101 DOI: 10.1128/Jvi.63.2.759-768.1989  0.613
1989 McCarthy AM, McMahan L, Schaffer PA. Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient. Journal of Virology. 63: 18-27. PMID 2535723  0.574
1989 Albrecht MA, DeLuca NA, Byrn RA, Schaffer PA, Hammer SM. The herpes simplex virus immediate-early protein, ICP4, is required to potentiate replication of human immunodeficiency virus in CD4+ lymphocytes Journal of Virology. 63: 1861-1868. PMID 2467991 DOI: 10.1128/Jvi.63.5.1861-1868.1989  0.738
1988 Desai PJ, Schaffer PA, Minson AC. Excretion of non-infectious virus particles lacking glycoprotein H by a temperature-sensitive mutant of herpes simplex virus type 1: evidence that gH is essential for virion infectivity. The Journal of General Virology. 69: 1147-56. PMID 2838568 DOI: 10.1099/0022-1317-69-6-1147  0.422
1988 Polvino-Bodnar M, Kiso J, Schaffer PA. Mutational analysis of Epstein-Barr virus nuclear antigen 1 (EBNA 1). Nucleic Acids Research. 16: 3415-35. PMID 2836795 DOI: 10.1093/Nar/16.8.3415  0.518
1988 DeLuca NA, Schaffer PA. Physical and functional domains of the herpes simplex virus transcriptional regulatory protein ICP4 Journal of Virology. 62: 732-743. PMID 2828668 DOI: 10.1128/Jvi.62.3.732-743.1988  0.739
1988 Marchetti ME, Smith CA, Schaffer PA. A temperature-sensitive mutation in a herpes simplex virus type 1 gene required for viral DNA synthesis maps to coordinates 0.609 through 0.614 in UL. Journal of Virology. 62: 715-21. PMID 2828666  0.414
1987 Deluca NA, Schaffer PA. Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides Nucleic Acids Research. 15: 4491-4511. PMID 3035496 DOI: 10.1093/Nar/15.11.4491  0.734
1987 Orberg PK, Schaffer PA. Expression of herpes simplex virus type 1 major DNA-binding protein, ICP8, in transformed cell lines: complementation of deletion mutants and inhibition of wild-type virus. Journal of Virology. 61: 1136-46. PMID 3029408  0.51
1987 Smith CA, Schaffer PA. Mutants defective in herpes simplex virus type 2 ICP4: isolation and preliminary characterization. Journal of Virology. 61: 1092-7. PMID 3029403  0.46
1987 Sacks WR, Schaffer PA. Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture. Journal of Virology. 61: 829-39. PMID 3027408  0.578
1987 Weller SK, Carmichael EP, Aschman DP, Goldstein DI, Schaffer PA. Genetic and phenotypic characterization of mutants in four essential genes that map to the left half of HSV-1 UL DNA Virology. 161: 198-210. PMID 2823462 DOI: 10.1016/0042-6822(87)90186-3  0.522
1987 Polvino-Bodnar M, Orberg PK, Schaffer PA. Herpes simplex virus type 1 oriL is not required for virus replication or for the establishment and reactivation of latent infection in mice. Journal of Virology. 61: 3528-35. PMID 2822960  0.585
1987 Smith CA, Schaffer PA. Intertypic recombinants of herpes simplex virus types 1 and 2 infected-cell polypeptide 4. Virology. 160: 176-82. PMID 2820127 DOI: 10.1016/0042-6822(87)90058-4  0.563
1986 Chenet-Monte C, Mohammad F, Celluzzi CM, Schaffer PA, Farber FE. Herpes simplex virus gene products involved in the induction of chromosomal aberrations. Virus Research. 6: 245-60. PMID 3033932 DOI: 10.1016/0168-1702(86)90073-0  0.609
1985 DeLuca NA, Schaffer PA. Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4 Molecular and Cellular Biology. 5: 1997-2008. PMID 3018543  0.7
1985 DeLuca NA, McCarthy AM, Schaffer PA. Isolation and characterization of deletion mutants of herpes simplex virus type 1 in the gene encoding immediate-early regulatory protein ICP4. Journal of Virology. 56: 558-70. PMID 2997476 DOI: 10.1128/Jvi.56.2.558-570.1985  0.707
1985 Sacks WR, Greene CC, Aschman DP, Schaffer PA. Herpes simplex virus type 1 ICP27 is an essential regulatory protein. Journal of Virology. 55: 796-805. PMID 2991596 DOI: 10.1128/Jvi.55.3.796-805.1985  0.619
1984 Schaffer PA, Weller SK, Pancake BA, Coen DM. Genetics of herpes simplex virus Journal of Investigative Dermatology. 83. PMID 6330220 DOI: 10.1038/Jid.1984.18  0.563
1984 Hall JD, Coen DM, Fisher BL, Weisslitz M, Randall S, Almy RE, Gelep PT, Schaffer PA. Generation of genetic diversity in herpes simplex virus: an antimutator phenotype maps to the DNA polymerase locus. Virology. 132: 26-37. PMID 6320535 DOI: 10.1016/0042-6822(84)90088-6  0.52
1984 Coen DM, Aschman DP, Gelep PT, Retondo MJ, Weller SK, Schaffer PA. Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus Journal of Virology. 49: 236-247. PMID 6317891 DOI: 10.1128/Jvi.49.1.236-247.1984  0.437
1984 Respess RA, Pancake BA, Edson CM, Schaffer PA. A rapid procedure for the enrichment of undenaturated, antigenically active herpes simplex virus glycoproteins. Journal of Virological Methods. 8: 27-45. PMID 6200489 DOI: 10.1016/0166-0934(84)90038-7  0.478
1984 DeLuca NA, Courtney MA, Schaffer PA. Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression Journal of Virology. 52: 767-776. PMID 6092709  0.722
1983 Weller SK, Aschman DP, Sacks WR, Coen DM, Schaffer PA. Genetic analysis of temperature-sensitive mutants of HSV-1: The combined use of complementation and physical mapping for cistron assignment Virology. 130: 290-305. PMID 6316633 DOI: 10.1016/0042-6822(83)90084-3  0.374
1983 Pancake BA, Aschman DP, Schaffer PA. Genetic and phenotypic analysis of herpes simplex virus type 1 mutants conditionally resistant to immune cytolysis. Journal of Virology. 47: 568-85. PMID 6312082 DOI: 10.1128/Jvi.47.3.568-585.1983  0.551
1983 Coen DM, Furman PA, Aschman DP, Schaffer PA. Mutations in the herpes simplex virus DNA polymerase gene conferring hypersensitivity to aphidicolin Nucleic Acids Research. 11: 5287-5297. PMID 6308578 DOI: 10.1093/Nar/11.15.5287  0.536
1983 Weller SK, Lee KJ, Sabourin DJ, Schaffer PA. Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein Journal of Virology. 45: 354-366. PMID 6296442 DOI: 10.1128/Jvi.45.1.354-366.1983  0.553
1983 Dixon RA, Sabourin DJ, Schaffer PA. Genetic analysis of temperature-sensitive mutants which define the genes for the major herpes simplex virus type 2 DNA-binding protein and a new late function. Journal of Virology. 45: 343-53. PMID 6296441 DOI: 10.1128/Jvi.45.1.343-353.1983  0.55
1982 Coen DM, Schaffer PA, Furman PA, Keller PM, CLAIR MHS. Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1 The American Journal of Medicine. 73: 351-360. PMID 6285722 DOI: 10.1016/0002-9343(82)90122-X  0.425
1982 Coen DM, Furman PA, Gelep PT, Schaffer PA. Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-β-D-arabinofuranosyladenine Journal of Virology. 41: 909-918. PMID 6284981 DOI: 10.1128/Jvi.41.3.909-918.1982  0.506
1981 Furman PA, Coen DM, St. Clair MH, Schaffer PA. Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities Journal of Virology. 40: 936-941. PMID 6275127 DOI: 10.1128/Jvi.40.3.936-941.1981  0.446
1981 Little SP, Jofre JT, Courtney RJ, Schaffer PA. A virion-associated glycoprotein essential for infectivity of herpes simplex virus type 1. Virology. 115: 149-60. PMID 6270896 DOI: 10.1016/0042-6822(81)90097-0  0.641
1981 Little SP, Schaffer PA. Expression of the syncytial (syn) phenotype in HSV-1, strain KOS: genetic and phenotypic studies of mutants in two syn loci. Virology. 112: 686-702. PMID 6266147 DOI: 10.1016/0042-6822(81)90314-7  0.465
1981 Jofre JT, Courtney RJ, Schaffer PA. A dominant lethal temperature-sensitive mutant of herpes simplex virus type 1. Virology. 111: 173-90. PMID 6262999 DOI: 10.1016/0042-6822(81)90663-2  0.622
1980 Dixon RA, Schaffer PA. Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. Journal of Virology. 36: 189-203. PMID 6255206  0.372
1980 Chartrand P, Crumpacker CS, Schaffer PA, Wilkie NM. Physical and genetic analysis of the herpes simplex virus DNA polymerase locus. Virology. 103: 311-26. PMID 6247818 DOI: 10.1016/0042-6822(80)90190-7  0.381
1980 Rapp F, Turner N, Schaffer PA. Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1. Journal of Virology. 34: 704-10. PMID 6247507  0.376
1980 Coen DM, Schaffer PA. Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1 Proceedings of the National Academy of Sciences of the United States of America. 77: 2265-2269. PMID 6246531 DOI: 10.1073/Pnas.77.4.2265  0.401
1980 Machtiger NA, Pancake BA, Eberle R, Courtney RJ, Tevethia SS, Schaffer PA. Herpes simplex virus glycoproteins: isolation of mutants resistant to immune cytolysis. Journal of Virology. 34: 336-46. PMID 6246268 DOI: 10.1128/Jvi.34.2.336-346.1980  0.538
1980 Cabral GA, Courtney RJ, Schaffer PA, Marciano-Cabral F. Ultrastructural characterization of an early, nonstructural polypeptide of herpes simplex virus type 1 Journal of Virology. 33: 1192-1198. PMID 6245269 DOI: 10.1128/Jvi.33.3.1192-1198.1980  0.554
1980 Parris DS, Dixon RA, Schaffer PA. Physical mapping of herpes simplex virus type 1 ts mutants by marker rescue: correlation of the physical and genetic maps. Virology. 100: 275-87. PMID 6243429 DOI: 10.1016/0042-6822(80)90519-X  0.448
1979 Chu CT, Parris DS, Dixon RA, Farber FE, Schaffer PA. Hydroxylamine mutagenesis of HSV DNA and DNA fragments: introduction of mutations into selected regions of the viral genome. Virology. 98: 168-81. PMID 225860 DOI: 10.1016/0042-6822(79)90535-X  0.43
1979 Parris DS, Courtney RJ, Schaffer PA. Temperature-sensitive mutants of herpes simplex virus type 1 defective in transcriptional and post-transcriptional functions required for viral DNA synthesis. Virology. 90: 177-86. PMID 214940 DOI: 10.1016/0042-6822(78)90301-X  0.528
1979 Bookout JB, Schaffer PA, Purifoy DJ, Biswal N. Marker rescue of temperature-sensitive mutants by defective DNA of herpes simplex virus type 1. Virology. 89: 528-38. PMID 213880 DOI: 10.1016/0042-6822(78)90194-0  0.476
1978 Schaffer PA, Carter VC, Timbury MC. Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2. Journal of Virology. 27: 490-504. PMID 212578 DOI: 10.1128/Jvi.27.3.490-504.1978  0.566
1978 Kit S, Dubbs DR, Schaffer PA. Thymidine kinase activity of biochemically transformed mouse cells after superinfection by thymidine kinase-negative, temperature-sensitive, herpes simplex virus mutants. Virology. 85: 456-63. PMID 208236 DOI: 10.1016/0042-6822(78)90452-X  0.355
1978 Morse LS, Pereira L, Roizman B, Schaffer PA. Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants. Journal of Virology. 26: 389-410. PMID 207894 DOI: 10.1128/Jvi.26.2.389-410.1978  0.346
1977 Morse LS, Buchman TG, Roizman B, Schaffer PA. Anatomy of herpes simplex virus DNA. IX. Apparent exclusion of some parental DNA arrangements in the generation of intertypic (HSV-1 X HSV-2) recombinants. Journal of Virology. 24: 231-48. PMID 198577 DOI: 10.1128/Jvi.24.1.231-248.1977  0.443
1977 Jofre JT, Schaffer PA, Parris DS. Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1. Journal of Virology. 23: 833-6. PMID 197275 DOI: 10.1128/Jvi.23.3.833-836.1977  0.555
1977 Courtney RJ, Schaffer PA, Powell KL. Synthesis of virus-specific polypaptides by temperature-sensitive mutants of herpes simplex virus type 1. Virology. 75: 306-18. PMID 188235 DOI: 10.1016/0042-6822(76)90030-1  0.587
1977 Flannery VL, Courtney RJ, Schaffer PA. Expression of an early, nonstructural antigen of herpes simplex virus in cell transformed in vitro by herpes simplex virus. Journal of Virology. 21: 284-91. PMID 64626 DOI: 10.1128/Jvi.21.1.284-291.1977  0.474
1976 Timbury MC, Hendricks ML, Schaffer PA. Collaborative study of temperature-sensitive mutants of herpes simplex virus type 2. Journal of Virology. 18: 1139-42. PMID 178919 DOI: 10.1128/Jvi.18.3.1139-1142.1976  0.472
1976 Cabral GA, Schaffer PA. Electron microscope studies of temperature-sensitive mutants of herpes simplex virus type 2. Journal of Virology. 18: 727-37. PMID 178905 DOI: 10.1128/jvi.18.2.727-737.1976  0.509
1976 Esparza J, Benyesh-Melnick B, Schaffer PA. Intertypic complementation and recombination between temperature-sensitive mutants of herpes simplex virus types 1 and 2. Virology. 70: 372-84. PMID 178095 DOI: 10.1016/0042-6822(76)90279-8  0.588
1976 Schaffer PA, Bone DR, Courtney RJ. DNA-negative temperature-sensitive mutants of herpes simplex virus type 1: patterns of viral DNA synthesis after temperature shift-up. Journal of Virology. 17: 1043-8. PMID 176439 DOI: 10.1128/Jvi.17.3.1043-1048.1976  0.542
1976 Schaffer PA, Falk LA, Deinhardt F. Attenuation of herpesvirus saimiri for marmosets after successive passage in cell culture at 39 degrees C. Journal of the National Cancer Institute. 55: 1243-6. PMID 173864 DOI: 10.1093/jnci/55.5.1243  0.324
1975 Chu CT, Schaffer PA. Qualitative complementation test for temperature-sensitive mutants of herpes simplex virus. Journal of Virology. 16: 1131-6. PMID 171444 DOI: 10.1128/Jvi.16.5.1131-1136.1975  0.504
1975 Aron GM, Purifoy DJ, Schaffer PA. DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants. Journal of Virology. 16: 498-507. PMID 169388 DOI: 10.1128/Jvi.16.3.498-507.1975  0.486
1975 Benyesh-Melnick M, Schaffer PA, Courtney RJ, Esparza J, Kimura S. Viral gene functions expressed and detected by temperature-sensitive mutants of herpes simplex virus. Cold Spring Harbor Symposia On Quantitative Biology. 39: 731-46. PMID 169028 DOI: 10.1101/Sqb.1974.039.01.086  0.602
1975 Kimura S, Flannery VL, Levy B, Schaffer PA. Oncogenic transformation of primary hamster cells by herpes simplex virus type 2 (hsv-2) and an hsv-2 temperature-sensitive mutant. International Journal of Cancer. 15: 786-98. PMID 166948 DOI: 10.1002/Ijc.2910150510  0.448
1974 Kimura S, Esparza J, Benyesh-Melnick M, Schaffer PA. Enhanced replication of temperature-sensitive mutants of herpes simplex virus type 2 (HSV-2) at the nonpermissive temperature in cells transformed by HSV-2. Intervirology. 3: 162-9. PMID 4374446 DOI: 10.1159/000149752  0.52
1974 Schaffer PA, Brunschwig JP, McCombs RM, Benyesh-Melnick M. Electron microscopic studies of temperature-sensitive mutants of herpes simplex virus type 1. Virology. 62: 444-57. PMID 4372787 DOI: 10.1016/0042-6822(74)90406-1  0.564
1974 Drake S, Schaffer PA, Esparza J, Mayor HD. Complementation of adeno-associated satellite viral antigens and infectious DNA by temperature-sensitive mutants of herpes simplex virus. Virology. 60: 230-6. PMID 4366931 DOI: 10.1016/0042-6822(74)90380-8  0.579
1974 Schaffer PA, Tevethia MJ, Benyesh-Melnick M. Recombination between temperature-sensitive mutants of herpes simplex virus type 1. Virology. 58: 219-28. PMID 4362547 DOI: 10.1016/0042-6822(74)90156-1  0.5
1974 Esparza J, Purifoy DJ, Schaffer PA, Benyesh-Melnick M. Isolation, complementation and preliminary phenotypic characterization of temperature-sensitive mutants of herpes simplex virus type 2. Virology. 57: 554-65. PMID 4361460 DOI: 10.1016/0042-6822(74)90194-9  0.508
1974 Schaffer PA, Scherer WF. Growth of Venezuelan encephalitis virus and disapperance of coxsackie A, Rous sarcoma, herpes simplex and vaccinia viruses following inoculation of Aedes aegypti and other mosquitoes. Journal of Medical Entomology. 11: 189-96. PMID 4152894 DOI: 10.1093/jmedent/11.2.189  0.668
1973 Schaffer PA, Aron GM, Biswal N, Benyesh-Melnick M. Temperature-sensitive mutants of herpes simplex virus type 1: isolation, complementation and partial characterization. Virology. 52: 57-71. PMID 4372782 DOI: 10.1016/0042-6822(73)90398-X  0.553
1973 Aron GM, Schaffer PA, Courtney RJ, Benyesh-Melnick M, Kit S. Thymidine kinase activity of herpes simplex virus temperature-sensitive mutants. Intervirology. 1: 96-109. PMID 4359194 DOI: 10.1159/000148836  0.558
1972 Schaffer PA, Scherer WF. Growth of a candidate arbovirus (Tsuruse) in Aedes aegypti mosquitoes following intrathoracic inoculation. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 139: 1298-304. PMID 4554052 DOI: 10.3181/00379727-139-36351  0.644
1971 Schaffer PA, Scherer WF. Stability of virulence and plaque size of Venezuelan encephalitis virus with passage in Mosquitoes (Aedes aegypti). American Journal of Epidemiology. 93: 68-74. PMID 5539571 DOI: 10.1093/Oxfordjournals.Aje.A121229  0.64
1971 Scherer WF, Dickerman RW, Diaz-Najera A, Ward BA, Miller MH, Schaffer PA. Ecologic studies of Venezuelan encephalitis virus in southeastern México. 3. Infection of mosquitoes American Journal of Tropical Medicine and Hygiene. 20: 969-979. PMID 4399818  0.676
1971 Schaffer PA, Courtney RJ, McCombs RM, Benyesh-Melnick M. A temperature-sensitive mutant of herpes simplex virus defective in glycoprotein synthesis. Virology. 46: 356-68. PMID 4108618 DOI: 10.1016/0042-6822(71)90037-7  0.573
1970 Schaffer P, Vonka V, Lewis R, Benyesh-Melnick M. Temperature-sensitive mutants of herpes simplex virus Virology. 42: 1144-1146. PMID 4321307 DOI: 10.1016/0042-6822(70)90364-8  0.532
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