Richard L. Klemke, Ph.D. - Publications

Affiliations: 
Pathology University of California, San Diego, La Jolla, CA 
Area:
Cancer

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang H, Lapek J, Fujimura K, Strnadel J, Liu B, Gonzalez DJ, Zhang W, Watson F, Yu V, Liu C, Melo CM, Miller YI, Elliott KC, Cheresh DA, Klemke RL. Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription. Cell Discovery. 4: 26. PMID 29872538 DOI: 10.1038/s41421-018-0024-3  0.44
2017 Strnadel J, Choi S, Fujimura K, Wang H, Zhang W, Wyse M, Wright T, Gross E, Peinado C, Park HW, Bui J, Kelber J, Bouvet M, Guan KL, Klemke RL. eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth. Cancer Research. PMID 28381547 DOI: 10.1158/0008-5472.CAN-16-2594  0.4
2015 Fujimura K, Choi S, Wyse M, Strnadel J, Wright T, Klemke R. Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. The Journal of Biological Chemistry. PMID 26483550 DOI: 10.1074/jbc.M115.687418  1
2015 Agajanian M, Campeau A, Hoover M, Hou A, Brambilla D, Kim SL, Klemke RL, Kelber JA. PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer. Plos One. 10: e0135748. PMID 26267863 DOI: 10.1371/journal.pone.0135748  1
2015 Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR, Klemke R, Gonias SL, Coppinger JA. Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and major vault protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation. Molecular & Cellular Proteomics : McP. 14: 1-14. PMID 24997994 DOI: 10.1074/mcp.M114.037697  1
2014 Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA, Klemke RL. A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Research. 74: 6671-81. PMID 25261239 DOI: 10.1158/0008-5472.CAN-14-1031  1
2014 Spike BT, Kelber JA, Booker E, Kalathur M, Rodewald R, Lipianskaya J, La J, He M, Wright T, Klemke R, Wahl GM, Gray PC. CRIPTO/GRP78 signaling maintains fetal and adult mammary stem cells ex vivo. Stem Cell Reports. 2: 427-39. PMID 24749068 DOI: 10.1016/j.stemcr.2014.02.010  1
2014 Choi S, Kelber J, Jiang X, Strnadel J, Fujimura K, Pasillas M, Coppinger J, Klemke R. Procedures for the biochemical enrichment and proteomic analysis of the cytoskeletome. Analytical Biochemistry. 446: 102-7. PMID 24161902 DOI: 10.1016/j.ab.2013.10.025  1
2013 Klemke RL, Jiang X, Choi S, Kelber JA. Proteomic and biochemical methods to study the cytoskeletome. Methods in Molecular Biology (Clifton, N.J.). 1046: 203-18. PMID 23868590 DOI: 10.1007/978-1-62703-538-5_12  1
2013 Stoletov K, Strnadel J, Zardouzian E, Momiyama M, Park FD, Kelber JA, Pizzo DP, Hoffman R, VandenBerg SR, Klemke RL. Role of connexins in metastatic breast cancer and melanoma brain colonization. Journal of Cell Science. 126: 904-13. PMID 23321642 DOI: 10.1242/jcs.112748  1
2013 Bristow JM, Reno TA, Jo M, Gonias SL, Klemke RL. Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. The Journal of Biological Chemistry. 288: 123-31. PMID 23105102 DOI: 10.1074/jbc.M112.410910  1
2012 Klemke RL. Trespassing cancer cells: 'fingerprinting' invasive protrusions reveals metastatic culprits. Current Opinion in Cell Biology. 24: 662-9. PMID 22980730 DOI: 10.1016/j.ceb.2012.08.005  1
2012 Soman P, Kelber JA, Lee JW, Wright TN, Vecchio KS, Klemke RL, Chen S. Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials. 33: 7064-70. PMID 22809641 DOI: 10.1016/j.biomaterials.2012.06.012  1
2012 Kelber JA, Reno T, Kaushal S, Metildi C, Wright T, Stoletov K, Weems JM, Park FD, Mose E, Wang Y, Hoffman RM, Lowy AM, Bouvet M, Klemke RL. KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Research. 72: 2554-64. PMID 22589274 DOI: 10.1158/0008-5472.CAN-11-3552  1
2012 Wang Y, Klemke RL. Proteomics method for identification of pseudopodium phosphotyrosine proteins. Methods in Molecular Biology (Clifton, N.J.). 757: 349-65. PMID 21909922 DOI: 10.1007/978-1-61779-166-6_21  1
2011 Wang Y, Yang F, Gritsenko MA, Wang Y, Clauss T, Liu T, Shen Y, Monroe ME, Lopez-Ferrer D, Reno T, Moore RJ, Klemke RL, Camp DG, Smith RD. Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics. 11: 2019-26. PMID 21500348 DOI: 10.1002/pmic.201000722  1
2011 Wang Y, Yang F, Fu Y, Huang X, Wang W, Jiang X, Gritsenko MA, Zhao R, Monore ME, Pertz OC, Purvine SO, Orton DJ, Jacobs JM, Camp DG, Smith RD, ... Klemke RL, et al. Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. The Journal of Biological Chemistry. 286: 18190-201. PMID 21454597 DOI: 10.1074/jbc.M111.236133  1
2011 Kelber JA, Klemke RL. The Actin Cytoskeleton Cellular Domains. 197-212. DOI: 10.1002/9781118015759.ch12  1
2010 Kelber JA, Klemke RL. PEAK1, a novel kinase target in the fight against cancer. Oncotarget. 1: 219-23. PMID 21301050  1
2010 Jo M, Eastman BM, Webb DL, Stoletov K, Klemke R, Gonias SL. Cell signaling by urokinase-type plasminogen activator receptor induces stem cell-like properties in breast cancer cells. Cancer Research. 70: 8948-58. PMID 20940399 DOI: 10.1158/0008-5472.CAN-10-1936  1
2010 Jin H, Garmy-Susini B, Avraamides CJ, Stoletov K, Klemke RL, Varner JA. A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood. 116: 5773-83. PMID 20826718 DOI: 10.1182/blood-2010-07-296210  1
2010 Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke RL. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proceedings of the National Academy of Sciences of the United States of America. 107: 10920-5. PMID 20534451 DOI: 10.1073/pnas.0914776107  1
2010 Stoletov K, Kato H, Zardouzian E, Kelber J, Yang J, Shattil S, Klemke R. Visualizing extravasation dynamics of metastatic tumor cells. Journal of Cell Science. 123: 2332-41. PMID 20530574 DOI: 10.1242/jcs.069443  1
2010 Sampathkumar P, Ozyurt SA, Miller SA, Bain KT, Rutter ME, Gheyi T, Abrams B, Wang Y, Atwell S, Luz JG, Thompson DA, Wasserman SR, Emtage JS, Park EC, Rongo C, ... ... Klemke RL, et al. Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1. Journal of Molecular Biology. 397: 883-92. PMID 20156452 DOI: 10.1016/j.jmb.2010.02.017  1
2010 Murphy EA, Shields DJ, Stoletov K, Dneprovskaia E, McElroy M, Greenberg JI, Lindquist J, Acevedo LM, Anand S, Majeti BK, Tsigelny I, Saldanha A, Walsh B, Hoffman RM, Bouvet M, ... Klemke RL, et al. Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proceedings of the National Academy of Sciences of the United States of America. 107: 4299-304. PMID 20154271 DOI: 10.1073/pnas.0909299107  1
2010 Wang Y, Kelber JA, Tran Cao HS, Cantin GT, Lin R, Wang W, Kaushal S, Bristow JM, Edgington TS, Hoffman RM, Bouvet M, Yates JR, Klemke RL. Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progession (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 24 (10920-10925) DOI: 10.1073/pnas.0914776107) Proceedings of the National Academy of Sciences of the United States of America. 107: 13556. DOI: 10.1073/pnas.1008849107  1
2009 Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL. Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. Plos One. 4: e6713. PMID 19696929 DOI: 10.1371/journal.pone.0006713  1
2009 Stoletov K, Fang L, Choi SH, Hartvigsen K, Hansen LF, Hall C, Pattison J, Juliano J, Miller ER, Almazan F, Crosier P, Witztum JL, Klemke RL, Miller YI. Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circulation Research. 104: 952-60. PMID 19265037 DOI: 10.1161/CIRCRESAHA.108.189803  1
2008 Ding SJ, Wang Y, Jacobs JM, Qian WJ, Yang F, Tolmachev AV, Du X, Wang W, Moore RJ, Monroe ME, Purvine SO, Waters K, Heibeck TH, Adkins JN, Camp DG, ... Klemke RL, et al. Quantitative phosphoproteome analysis of lysophosphatidic acid induced chemotaxis applying dual-step (18)O labeling coupled with immobilized metal-ion affinity chromatography. Journal of Proteome Research. 7: 4215-24. PMID 18785766 DOI: 10.1021/pr7007785  1
2008 Stoletov K, Klemke R. Catch of the day: Zebrafish as a human cancer model Oncogene. 27: 4509-4520. PMID 18372910 DOI: 10.1038/onc.2008.95  1
2008 Wrasidlo W, Mielgo A, Torres VA, Barbero S, Stoletov K, Suyama TL, Klemke RL, Gerwick WH, Carson DA, Stupack DG. The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proceedings of the National Academy of Sciences of the United States of America. 105: 2313-8. PMID 18268346 DOI: 10.1073/pnas.0712198105  1
2008 Pertz OC, Wang Y, Yang F, Wang W, Gay LJ, Gristenko MA, Clauss TR, Anderson DJ, Liu T, Auberry KJ, Camp DG, Smith RD, Klemke RL. Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proceedings of the National Academy of Sciences of the United States of America. 105: 1931-6. PMID 18245386 DOI: 10.1073/pnas.0706545105  1
2008 Wang Y, Klemke RL. PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Molecular & Cellular Proteomics : McP. 7: 145-62. PMID 17934212 DOI: 10.1074/mcp.M700207-MCP200  1
2007 Stoletov K, Montel V, Lester RD, Gonias SL, Klemke R. High-resolution imaging of the dynamic tumor cell-vascular interface in transparent zebrafish Proceedings of the National Academy of Sciences of the United States of America. 104: 17406-17411. PMID 17954920 DOI: 10.1073/pnas.0703446104  1
2007 Wang Y, Ding SJ, Wang W, Yang F, Jacobs JM, Camp D, Smith RD, Klemke RL. Methods for pseudopodia purification and proteomic analysis. Science's Stke : Signal Transduction Knowledge Environment. 2007: pl4. PMID 17712138 DOI: 10.1126/stke.4002007pl4  1
2007 Wang Y, Ding SJ, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG, Smith RD, Klemke RL. Profiling signaling polarity in chemotactic cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 8328-33. PMID 17494752 DOI: 10.1073/pnas.0701103104  1
2007 Wang Y, Klemke RL. Biochemical purification of pseudopodia from migratory cells. Methods in Molecular Biology (Clifton, N.J.). 370: 55-66. PMID 17416987 DOI: 10.1007/978-1-59745-353-0_5  1
2006 Wang Y, Hanley R, Klemke RL. Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer. Journal of Proteome Research. 5: 907-15. PMID 16602698 DOI: 10.1021/pr050390u  1
2006 Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 440: 1069-72. PMID 16547516 DOI: 10.1038/nature04665  1
2006 Holcomb M, Rufini A, Barilà D, Klemke RL. Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII. The Journal of Biological Chemistry. 281: 2430-40. PMID 16267043 DOI: 10.1074/jbc.M508454200  1
2005 Wozniak MA, Kwong L, Chodniewicz D, Klemke RL, Keely PJ. R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. Molecular Biology of the Cell. 16: 84-96. PMID 15525681 DOI: 10.1091/mbc.E04-04-0277  1
2004 Chodniewicz D, Klemke RL. Guiding cell migration through directed extension and stabilization of pseudopodia. Experimental Cell Research. 301: 31-7. PMID 15501442 DOI: 10.1016/j.yexcr.2004.08.006  1
2004 Chodniewicz D, Klemke RL. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochimica Et Biophysica Acta. 1692: 63-76. PMID 15246680 DOI: 10.1016/j.bbamcr.2004.03.006  1
2004 Lin YH, Park ZY, Lin D, Brahmbhatt AA, Rio MC, Yates JR, Klemke RL. Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. The Journal of Cell Biology. 165: 421-32. PMID 15138294 DOI: 10.1083/jcb.200311045  1
2003 Kain KH, Gooch S, Klemke RL. Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene. 22: 6071-80. PMID 12955086 DOI: 10.1038/sj.onc.1206930  1
2003 Smit M, Leng J, Klemke RL. Assay for neurite outgrowth quantification. Biotechniques. 35: 254-6. PMID 12951763  1
2003 Brahmbhatt AA, Klemke RL. ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. The Journal of Biological Chemistry. 278: 13016-25. PMID 12571246 DOI: 10.1074/jbc.M211873200  1
2002 Cho SY, Klemke RL. Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. The Journal of Cell Biology. 156: 725-36. PMID 11839772 DOI: 10.1083/jcb.200111032  1
2001 Ting AY, Kain KH, Klemke RL, Tsien RY. Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 15003-8. PMID 11752449 DOI: 10.1073/pnas.211564598  1
2001 Kain KH, Klemke RL. Inhibition of cell migration by Abl family tyrosine kinases through uncoupling of Crk-CAS complexes. The Journal of Biological Chemistry. 276: 16185-92. PMID 11279004 DOI: 10.1074/jbc.M100095200  1
2000 Stupack DG, Cho SY, Klemke RL. Molecular signaling mechanisms of cell migration and invasion. Immunologic Research. 21: 83-8. PMID 10852105 DOI: 10.1385/IR:21:2-3:83  1
2000 Li E, Stupack DG, Brown SL, Klemke R, Schlaepfer DD, Nemerow GR. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. The Journal of Biological Chemistry. 275: 14729-35. PMID 10799562 DOI: 10.1074/jbc.275.19.14729  1
2000 Cho SY, Klemke RL. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. The Journal of Cell Biology. 149: 223-36. PMID 10747099 DOI: 10.1083/jcb.149.1.223  1
2000 Spencer KS, Graus-Porta D, Leng J, Hynes NE, Klemke RL. ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases. The Journal of Cell Biology. 148: 385-97. PMID 10648571 DOI: 10.1083/jcb.148.2.385  1
1999 Leng J, Klemke RL, Reddy AC, Cheresh DA. Potentiation of cell migration by adhesion-dependent cooperative signals from the GTPase Rac and Raf kinase. The Journal of Biological Chemistry. 274: 37855-61. PMID 10608850 DOI: 10.1074/jbc.274.53.37855  1
1999 Cheresh DA, Leng J, Klemke RL. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells. The Journal of Cell Biology. 146: 1107-16. PMID 10477763 DOI: 10.1083/jcb.146.5.1107  1
1999 Voice JK, Klemke RL, Le A, Jackson JH. Four human ras homologs differ in their abilities to activate Raf-1, induce transformation, and stimulate cell motility. The Journal of Biological Chemistry. 274: 17164-70. PMID 10358073 DOI: 10.1074/jbc.274.24.17164  1
1998 Li E, Stupack D, Klemke R, Cheresh DA, Nemerow GR. Adenovirus endocytosis via α(v) integrins requires phosphoinositide-3- OH kinase Journal of Virology. 72: 2055-2061. PMID 9499060  1
1998 Eliceiri BP, Klemke R, Strömblad S, Cheresh DA. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis Journal of Cell Biology. 140: 1255-1263. PMID 9490736 DOI: 10.1083/jcb.140.5.1255  1
1998 Klemke RL, Leng J, Molander R, Brooks PC, Vuori K, Cheresh DA. CAS/Crk coupling serves as a "molecular switch" for induction of cell migration. The Journal of Cell Biology. 140: 961-72. PMID 9472046 DOI: 10.1083/jcb.140.4.961  1
1997 Klemke RL, Cai S, Giannini AL, Gallagher PJ, de Lanerolle P, Cheresh DA. Regulation of cell motility by mitogen-activated protein kinase. The Journal of Cell Biology. 137: 481-92. PMID 9128257 DOI: 10.1083/jcb.137.2.481  1
1997 Brooks PC, Klemke RL, Schon S, Lewis JM, Schwartz MA, Cheresh DA. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. The Journal of Clinical Investigation. 99: 1390-8. PMID 9077549 DOI: 10.1172/JCI119298  1
1995 Brooks PC, Stromblad S, Klemke R, Visscher D, Sarkar FH, Cheresh DA. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin Journal of Clinical Investigation. 96: 1815-1822. PMID 7560073  1
1994 Klemke RL, Yebra M, Bayna EM, Cheresh DA. Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin. The Journal of Cell Biology. 127: 859-66. PMID 7525598 DOI: 10.1083/jcb.127.3.859  1
1993 Klemke RL, Weitlauf HM. Comparison of the ontogeny of specific cell surface determinants on normal and delayed implanting mouse embryos. Journal of Reproduction and Fertility. 99: 167-72. PMID 7506791  1
1991 Klemke RL, Rogers SH. The effects of THC on macromolecular synthesis in preimplantation mouse embryos Research Communications in Substances of Abuse. 11: 207-210.  1
Show low-probability matches.