| Year |
Citation |
Score |
| 2023 |
Wei X, Douchez A, Lubell WD. 1,3,5,8-Tetrasubstituted 1,3,4-Benzotriazepin-2-one Scaffolds for β-Turn Mimicry without Stereogenic Carbon Centers: Synthesis and Conformational Analysis. The Journal of Organic Chemistry. PMID 36930829 DOI: 10.1021/acs.joc.3c00113 |
0.325 |
|
| 2022 |
Luo Z, Xu L, Tang X, Zhao X, He T, Lubell WD, Zhang J. Synthesis and biological evaluation of novel all-hydrocarbon cross-linked aza-stapled peptides. Organic & Biomolecular Chemistry. PMID 36190455 DOI: 10.1039/d2ob01496c |
0.338 |
|
| 2021 |
Mulamreddy R, Lubell WD. Constrained Dipeptide Surrogates: 5- and 7-Hydroxy Indolizidin-2-one Amino Acid Synthesis from Iodolactonization of Dehydro-2,8-diamino Azelates. Molecules (Basel, Switzerland). 27. PMID 35011297 DOI: 10.3390/molecules27010067 |
0.369 |
|
| 2021 |
Nguyen AMT, Brettell S, Douanne N, Duquette C, Corbeil A, Fajardo EF, Olivier M, Fernandez-Prada C, Lubell WD. Influence of -Methylation and Conformation on Almiramide Anti-Leishmanial Activity. Molecules (Basel, Switzerland). 26. PMID 34204673 DOI: 10.3390/molecules26123606 |
0.355 |
|
| 2021 |
Ohm RG, Mulumba M, Chingle RM, Ahsanullah, Zhang J, Chemtob S, Ong H, Lubell WD. Diversity-Oriented A-Macrocyclization for Studying Influences of Ring-Size and Shape of Cyclic Peptides: CD36 Receptor Modulators. Journal of Medicinal Chemistry. PMID 34161728 DOI: 10.1021/acs.jmedchem.1c00642 |
0.307 |
|
| 2021 |
Mulamreddy R, Hou X, Chemtob S, Lubell WD. 6-Hydroxymethyl Indolizidin-2-one Amino Acid Synthesis, Conformational Analysis, and Biomedical Application as Dipeptide Surrogates in Prostaglandin-F Modulators. Organic Letters. PMID 34161105 DOI: 10.1021/acs.orglett.1c01733 |
0.336 |
|
| 2021 |
Hamdane Y, Chauhan PS, Vutla S, Mulumba M, Ong H, Lubell WD. 5-Substituted -Aminoimidazolone Peptide Mimic Synthesis by Organocatalyzed Reactions of Azopeptides and Use in the Analysis of Biologically Active Backbone and Side-Chain Topology. Organic Letters. 23: 3491-3495. PMID 33886343 DOI: 10.1021/acs.orglett.1c00936 |
0.366 |
|
| 2020 |
Frégeau G, Sarduy R, Elimam H, Esposito CL, Mellal K, Ménard L, Leitão da Graça SD, Proulx C, Zhang J, Febbraio M, Soto Y, Lubell WD, Ong H, Marleau S. Atheroprotective and atheroregressive potential of azapeptide derivatives of GHRP-6 as selective CD36 ligands in apolipoprotein E-deficient mice. Atherosclerosis. 307: 52-62. PMID 32721647 DOI: 10.1016/J.Atherosclerosis.2020.06.010 |
0.666 |
|
| 2020 |
Proulx C, Zhang J, Sabatino D, Chemtob S, Ong H, Lubell WD. Synthesis and Biomedical Potential of Azapeptide Modulators of the Cluster of Differentiation 36 Receptor (CD36). Biomedicines. 8. PMID 32717955 DOI: 10.3390/Biomedicines8080241 |
0.656 |
|
| 2020 |
Chauhan PS, Brettell S, Ramakotaiah M, Diarra S, Nguyen AMT, Wei X, Hamdane Y, Yongo-Luwawa CD, Lubell WD. Hydrazine derivative synthesis by trifluoroacetyl hydrazide alkylation Canadian Journal of Chemistry. 98: 485-494. DOI: 10.1139/Cjc-2020-0052 |
0.411 |
|
| 2020 |
Poupart J, Hamdane Y, Lubell WD. Synthesis of enantiomerically enriched 4,5-disubstituted N-aminoimidazol-2-one (Nai) peptide turn mimics Canadian Journal of Chemistry. 98: 278-284. DOI: 10.1139/Cjc-2019-0479 |
0.516 |
|
| 2020 |
Mulamreddy R, Lubell WD. Constrained Glu‐Gly and Gln‐Gly dipeptide surrogates from γ‐substituted α‐amino‐δ‐lactam synthesis Biopolymers. 112. DOI: 10.1002/Pep2.24149 |
0.338 |
|
| 2019 |
Danelius E, Ohm RG, Ahsanullah A, Mulumba M, Ong H, Chemtob S, Erdélyi M, Lubell WD. Dynamic Chirality in the Mechanism of Action of Allosteric CD36 Modulators of Macrophage-Driven Inflammation. Journal of Medicinal Chemistry. PMID 31774287 DOI: 10.1021/Acs.Jmedchem.9B00918 |
0.419 |
|
| 2019 |
Poupart J, Hou X, Chemtob S, Lubell WD. Application of -Dodecyl l-Peptide to Enhance Serum Stability while Maintaining Inhibitory Effects on Myometrial Contractions Ex Vivo. Molecules (Basel, Switzerland). 24. PMID 31731725 DOI: 10.3390/Molecules24224141 |
0.346 |
|
| 2019 |
Atmuri NDP, Lubell WD. Stereo- and regiochemical transannular cyclization of a common hexahydro-1H-azonine to afford three different indolizidinone dipeptide mimetics. The Journal of Organic Chemistry. PMID 31642317 DOI: 10.1021/Acs.Joc.9B01861 |
0.445 |
|
| 2019 |
Mir FM, Crisma M, Toniolo C, Lubell WD. Isolated α-turn and incipient γ-helix. Chemical Science. 10: 6908-6914. PMID 31391913 DOI: 10.1039/C9Sc01683J |
0.379 |
|
| 2019 |
Crifar C, Dücker FL, Nguyen Thanh S, Kairouz V, Lubell WD. Heumann Indole Flow Chemistry Process. The Journal of Organic Chemistry. PMID 31314527 DOI: 10.1021/Acs.Joc.9B01516 |
0.313 |
|
| 2019 |
Chingle R, Mulumba M, Chung NN, Nguyen TM, Ong H, Ballet S, Schiller PW, Lubell WD. Solid-Phase Azopeptide Diels-Alder Chemistry for Aza-Pipecolyl Residue Synthesis to Study Peptide Conformation. The Journal of Organic Chemistry. PMID 30957495 DOI: 10.1021/Acs.Joc.8B03283 |
0.493 |
|
| 2019 |
M Mir F, Atmuri NDP, Bourguet CB, Fores JR, Hou X, Chemtob S, Lubell WD. Paired Utility of Aza-Amino Acyl Proline and Indolizidinone Amino Acid Residues for Peptide Mimicry: Conception of Prostaglandin F2α Receptor Allosteric Modulators that Delay Preterm Birth. Journal of Medicinal Chemistry. PMID 30932486 DOI: 10.1021/Acs.Jmedchem.9B00056 |
0.48 |
|
| 2019 |
Geranurimi A, Cheng CWH, Quiniou C, Zhu T, Hou X, Rivera JC, St-Cyr DJ, Beauregard K, Bernard-Gauthier V, Chemtob S, Lubell WD. Probing Anti-inflammatory Properties Independent of NF-κB Through Conformational Constraint of Peptide-Based Interleukin-1 Receptor Biased Ligands. Frontiers in Chemistry. 7: 23. PMID 30815434 DOI: 10.3389/Fchem.2019.00023 |
0.349 |
|
| 2019 |
Merlino F, Billard E, Yousif AM, Di Maro S, Brancaccio D, Abate L, Carotenuto A, Bellavita R, d'Emmanuele di Villa Bianca R, Santicioli P, Marinelli L, Novellino E, Hébert T, Lubell WD, Chatenet D, et al. Functional Selectivity Revealed by N-Methylation Scanning of Human Urotensin II and Related Peptides. Journal of Medicinal Chemistry. PMID 30615452 DOI: 10.1021/Acs.Jmedchem.8B01601 |
0.426 |
|
| 2019 |
Mir FM, Crisma M, Toniolo C, Lubell WD. Influence of the C‐terminal substituent on the crystal‐state conformation of Adm peptides Peptide Science. 112. DOI: 10.1002/Pep2.24121 |
0.452 |
|
| 2019 |
Lubell WD. Emerging Peptide Science in Canada Peptide Science. 111: e24109. DOI: 10.1002/Pep2.24109 |
0.382 |
|
| 2018 |
Turcotte S, Mellal K, Chingle R, Mulumba M, Omri S, Dif-Yaiche L, Chemtob S, Ong H, Lubell WD. Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization. Biomedicines. 6. PMID 30360354 DOI: 10.3390/Biomedicines6040098 |
0.303 |
|
| 2018 |
Douchez A, Geranurimi A, Lubell WD. Applications of γ,δ-Unsaturated Ketones Synthesized by Copper-Catalyzed Cascade Addition of Vinyl Grignard Reagents to Esters. Accounts of Chemical Research. PMID 30289682 DOI: 10.1021/Acs.Accounts.8B00388 |
0.391 |
|
| 2018 |
Mulamreddy R, Atmuri NDP, Lubell WD. 4-Vinylproline. The Journal of Organic Chemistry. PMID 30247028 DOI: 10.1021/acs.joc.8b02177 |
0.39 |
|
| 2018 |
Geranurimi A, Lubell WD. Diversity-Oriented Syntheses of β-Substituted α-Amino γ-Lactam Peptide Mimics with Constrained Backbone and Side Chain Residues. Organic Letters. 20: 6126-6129. PMID 30230341 DOI: 10.1021/Acs.Orglett.8B02575 |
0.426 |
|
| 2018 |
Frégeau G, Sarduy R, Ménard L, Machane S, Mahroug A, Proulx C, Lubell WD, Ong H, Marleau S. Athroprotective and Atheroregressive Potential of an [aza-Y4]-GHRP-6 Analogue, a Selective CD36 Ligand, in Apolipoprotein E-deficient Mice Atherosclerosis Supplements. 32: 160-161. DOI: 10.1016/J.Atherosclerosissup.2018.04.486 |
0.639 |
|
| 2017 |
Douchez A, Billard É, Hébert T, Chatenet D, Lubell WD. Design, synthesis and biological assessment of biased allosteric modulation of the urotensin II receptor using achiral 1,3,4-benzotriazepin-2-one turn mimics. Journal of Medicinal Chemistry. PMID 29131958 DOI: 10.1021/Acs.Jmedchem.7B01525 |
0.374 |
|
| 2017 |
Chignen Possi K, Mulumba M, Omri S, Garcia-Ramos Y, Tahiri H, Chemtob S, Ong H, Lubell WD. Influences of Histidine-1 and Azaphenylalanine-4 on the Affinity, Anti-inflammatory and Antiangiogenic Activities of Azapeptide Cluster of Differentiation 36 Receptor Modulators. Journal of Medicinal Chemistry. PMID 29028172 DOI: 10.1021/Acs.Jmedchem.7B01209 |
0.383 |
|
| 2017 |
Huynh DN, Bessi VL, Ménard L, Piquereau J, Proulx C, Febbraio M, Lubell WD, Carpentier AC, Burelle Y, Ong H, Marleau S. Adiponectin has a pivotal role in the cardioprotective effect of CP-3(iv), a selective CD36 azapeptide ligand, after transient coronary artery occlusion in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29018142 DOI: 10.1096/Fj.201700505R |
0.642 |
|
| 2017 |
Atmuri NDP, Reilley DJ, Lubell WD. Peptidomimetic Synthesis by Way of Diastereoselective Iodoacetoxylation and Transannular Amidation of 7-9-Membered Lactams. Organic Letters. PMID 28949548 DOI: 10.1021/Acs.Orglett.7B02275 |
0.447 |
|
| 2017 |
Strack M, Billard É, Chatenet D, Lubell WD. Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II. Bioorganic & Medicinal Chemistry Letters. PMID 28625362 DOI: 10.1016/J.Bmcl.2017.05.088 |
0.477 |
|
| 2017 |
Chingle R, Proulx C, Lubell WD. Azapeptide Synthesis Methods for Expanding Side-Chain Diversity for Biomedical Applications. Accounts of Chemical Research. PMID 28598597 DOI: 10.1021/Acs.Accounts.7B00114 |
0.757 |
|
| 2017 |
Traoré M, Gignac M, Doan ND, Hof F, Lubell WD. Aza-amino acid scanning of chromobox homolog 7 (CBX7) ligands. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 28220557 DOI: 10.1002/Psc.2982 |
0.795 |
|
| 2017 |
Nadeau-Vallée M, Chin PY, Belarbi L, Brien MÈ, Pundir S, Berryer MH, Beaudry-Richard A, Madaan A, Sharkey DJ, Lupien-Meilleur A, Hou X, Quiniou C, Beaulac A, Boufaied I, Boudreault A, ... ... Lubell WD, et al. Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 28148737 DOI: 10.4049/Jimmunol.1601600 |
0.674 |
|
| 2017 |
Zhang J, Mulumba M, Ong H, Lubell WD. Diversity-Oriented Synthesis of Cyclic Azapeptides by A(3) -Macrocyclization Provides High-Affinity CD36-Modulating Peptidomimetics. Angewandte Chemie (International Ed. in English). PMID 28090719 DOI: 10.1002/Anie.201611685 |
0.408 |
|
| 2016 |
Merlino F, Yousif AM, Billard É, Dufour-Gallant J, Turcotte S, Grieco P, Chatenet D, Lubell WD. Urotensin II((4-11)) Azasulfuryl Peptides: Synthesis and Biological Activity. Journal of Medicinal Chemistry. PMID 27140209 DOI: 10.1021/Acs.Jmedchem.6B00108 |
0.472 |
|
| 2015 |
Douchez A, Lubell WD. Chemoselective Alkylation for Diversity-Oriented Synthesis of 1,3,4-Benzotriazepin-2-ones and Pyrrolo[1,2][1,3,4]benzotriazepin-6-ones, Potential Turn Surrogates. Organic Letters. 17: 6046-9. PMID 26629890 DOI: 10.1021/Acs.Orglett.5B03046 |
0.405 |
|
| 2015 |
Chingle R, Lubell WD. Azopeptides: Synthesis and Pericyclic Chemistry. Organic Letters. 17: 5400-3. PMID 26509791 DOI: 10.1021/Acs.Orglett.5B02723 |
0.366 |
|
| 2015 |
Papini AM, Lavielle S, Lubell WD. Peptides in Paris. Biopolymers. 104: v-vii. PMID 26400823 DOI: 10.1002/Bip.22738 |
0.413 |
|
| 2015 |
Dörr AA, Lubell WD. γ-Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesized from a Common Amino Ketone Intermediate. Organic Letters. 17: 3592-5. PMID 26125453 DOI: 10.1021/Acs.Orglett.5B01679 |
0.416 |
|
| 2015 |
Boukanoun MK, Hou X, Nikolajev L, Ratni S, Olson D, Claing A, Laporte SA, Chemtob S, Lubell WD. Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor. Organic & Biomolecular Chemistry. PMID 26090777 DOI: 10.1039/C5Ob00962F |
0.426 |
|
| 2015 |
Dufour-Gallant J, Chatenet D, Lubell WD. De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo. Journal of Medicinal Chemistry. 58: 4624-37. PMID 25984647 DOI: 10.1021/Acs.Jmedchem.5B00162 |
0.336 |
|
| 2015 |
Atmuri ND, Lubell WD. Insight into Transannular Cyclization Reactions To Synthesize Azabicyclo[X.Y.Z]alkanone Amino Acid Derivatives from 8-, 9-, and 10-Membered Macrocyclic Dipeptide Lactams. The Journal of Organic Chemistry. 80: 4904-18. PMID 25831452 DOI: 10.1021/Acs.Joc.5B00237 |
0.439 |
|
| 2015 |
Turcotte S, Lubell WD. Crystal structure analyses of azasulfuryltripeptides reveal potential for γ-turn mimicry. Biopolymers. 104: 622-8. PMID 25808245 DOI: 10.1002/Bip.22632 |
0.361 |
|
| 2015 |
Doan ND, Lubell WD. X-ray structure analysis reveals β-turn mimicry by N-amino-imidazolidin-2-ones. Biopolymers. 104: 629-35. PMID 25787802 DOI: 10.1002/Bip.22646 |
0.763 |
|
| 2015 |
Bourguet CB, Lubell WD. Synthesis and alkylation of Aza-Gly-Pro building blocks of peptidomimetic libraries for developing prostaglandin F2α receptor modulators as therapeutics to inhibit preterm labor. Methods in Molecular Biology (Clifton, N.J.). 1248: 81-91. PMID 25616327 DOI: 10.1007/978-1-4939-2020-4_6 |
0.391 |
|
| 2015 |
Doan ND, Zhang J, Traoré M, Kamdem W, Lubell WD. Solid-phase synthesis of C-terminal azapeptides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 21: 387-91. PMID 25400083 DOI: 10.1002/Psc.2711 |
0.755 |
|
| 2015 |
Crifar C, Dörr AA, Lubell WD. Copper-catalyzed cascade addition route to 2,3,4-trisubstituted quinoline derivatives Tetrahedron Letters. 56: 3451-3453. DOI: 10.1016/J.Tetlet.2015.01.071 |
0.346 |
|
| 2015 |
Atmuri NDP, Lubell WD. Preparation of N-(Boc)-Allylglycine Methyl Ester Using a Zinc-Mediated, Palladium-Catalyzed Cross-Coupling Reaction Organic Syntheses. 92: 103-116. DOI: 10.1002/0471264229.Os092.08 |
0.387 |
|
| 2014 |
Bourguet CB, Boulay PL, Claing A, Lubell WD. Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells. Bioorganic & Medicinal Chemistry Letters. 24: 3361-5. PMID 24986663 DOI: 10.1016/J.Bmcl.2014.05.095 |
0.361 |
|
| 2014 |
Traoré M, Doan ND, Lubell WD. Diversity-oriented synthesis of azapeptides with basic amino acid residues: aza-lysine, aza-ornithine, and aza-arginine. Organic Letters. 16: 3588-91. PMID 24959890 DOI: 10.1021/Ol501586Y |
0.799 |
|
| 2014 |
Khashper A, Lubell WD. Design, synthesis, conformational analysis and application of indolizidin-2-one dipeptide mimics. Organic & Biomolecular Chemistry. 12: 5052-70. PMID 24899358 DOI: 10.1039/C4Ob00777H |
0.486 |
|
| 2014 |
Doan ND, Hopewell R, Lubell WD. N-aminoimidazolidin-2-one peptidomimetics. Organic Letters. 16: 2232-5. PMID 24697286 DOI: 10.1021/Ol500739K |
0.787 |
|
| 2014 |
Zhang J, Proulx C, Tomberg A, Lubell WD. Multicomponent diversity-oriented synthesis of aza-lysine-peptide mimics. Organic Letters. 16: 298-301. PMID 24328523 DOI: 10.1021/Ol403297V |
0.734 |
|
| 2014 |
Proulx C, Lubell WD. Analysis of N-amino-imidazolin-2-one peptide turn mimic 4-position substituent effects on conformation by X-ray crystallography. Biopolymers. 102: 7-15. PMID 23897495 DOI: 10.1002/Bip.22327 |
0.748 |
|
| 2014 |
Lubell WD, Dörr AA. Aminophenylpyrrole Synthesis and Application to Pyrrolo[1,2-c]quinazolinone Synthesis Heterocycles. 88: 1149. DOI: 10.3987/Com-13-S(S)73 |
0.305 |
|
| 2014 |
Mbyas Saroukou MS, Skalski T, Skene WG, Lubell WD. Conjugated C3 symmetric aryl tripyrroles and aryl bipyrroles: Synthesis, optical and electronic properties Tetrahedron. 70: 450-458. DOI: 10.1016/J.Tet.2013.11.043 |
0.307 |
|
| 2013 |
Bouayad-Gervais SH, Lubell WD. Examination of the potential for adaptive chirality of the nitrogen chiral center in aza-aspartame. Molecules (Basel, Switzerland). 18: 14739-46. PMID 24288001 DOI: 10.3390/Molecules181214739 |
0.417 |
|
| 2013 |
Garcia-Ramos Y, Lubell WD. Synthesis and alkylation of aza-glycinyl dipeptide building blocks. Journal of Peptide Science : An Official Publication of the European Peptide Society. 19: 725-9. PMID 24203503 DOI: 10.1002/Psc.2572 |
0.409 |
|
| 2013 |
Jamieson AG, Boutard N, Sabatino D, Lubell WD. Peptide scanning for studying structure-activity relationships in drug discovery. Chemical Biology & Drug Design. 81: 148-65. PMID 23253136 DOI: 10.1111/Cbdd.12042 |
0.422 |
|
| 2012 |
Lubell WD. Peptide chemistry. The Journal of Organic Chemistry. 77: 7137-42. PMID 22954452 DOI: 10.1021/jo301775h |
0.304 |
|
| 2012 |
Lubell WD. Peptide chemistry. Organic Letters. 14: 4297-302. PMID 22954352 DOI: 10.1021/ol302276u |
0.304 |
|
| 2012 |
Proulx C, Lubell WD. N-Amino-imidazolin-2-one peptide mimic synthesis and conformational analysis. Organic Letters. 14: 4552-5. PMID 22892053 DOI: 10.1021/Ol302021N |
0.766 |
|
| 2012 |
Proulx C, Picard É, Boeglin D, Pohankova P, Chemtob S, Ong H, Lubell WD. Azapeptide analogues of the growth hormone releasing peptide 6 as cluster of differentiation 36 receptor ligands with reduced affinity for the growth hormone secretagogue receptor 1a. Journal of Medicinal Chemistry. 55: 6502-11. PMID 22712585 DOI: 10.1021/Jm300557T |
0.686 |
|
| 2012 |
Dörr AA, Lubell WD. Synthesis of protected 2-pyrrolylalanine for peptide chemistry and examination of its influence on prolyl amide isomer equilibrium. The Journal of Organic Chemistry. 77: 6414-22. PMID 22697371 DOI: 10.1021/Jo3005809 |
0.503 |
|
| 2012 |
Spiegel J, Mas-Moruno C, Kessler H, Lubell WD. Cyclic aza-peptide integrin ligand synthesis and biological activity. The Journal of Organic Chemistry. 77: 5271-8. PMID 22582818 DOI: 10.1021/Jo300311Q |
0.495 |
|
| 2012 |
Turcotte S, Bouayad-Gervais SH, Lubell WD. N-Aminosulfamide peptide mimic synthesis by alkylation of aza-sulfurylglycinyl peptides. Organic Letters. 14: 1318-21. PMID 22329516 DOI: 10.1021/Ol3001987 |
0.511 |
|
| 2011 |
Tshibaka T, Bishop S, Roche IU, Dufresne S, Lubell WD, Skene WG. Conjugated 4-methoxybipyrrole thiophene azomethines: synthesis, opto-electronic properties, and crystallographic characterization. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 10879-88. PMID 21882273 DOI: 10.1002/Chem.201101397 |
0.336 |
|
| 2011 |
Proulx C, Sabatino D, Hopewell R, Spiegel J, García Ramos Y, Lubell WD. Azapeptides and their therapeutic potential. Future Medicinal Chemistry. 3: 1139-64. PMID 21806378 DOI: 10.4155/Fmc.11.74 |
0.733 |
|
| 2011 |
Bourguet CB, Goupil E, Tassy D, Hou X, Thouin E, Polyak F, Hébert TE, Claing A, Laporte SA, Chemtob S, Lubell WD. Targeting the prostaglandin F2α receptor for preventing preterm labor with azapeptide tocolytics. Journal of Medicinal Chemistry. 54: 6085-97. PMID 21774512 DOI: 10.1021/Jm200608K |
0.331 |
|
| 2011 |
Bolduc OR, Lambert-Lanteigne P, Colin DY, Zhao SS, Proulx C, Boeglin D, Lubell WD, Pelletier JN, Féthière J, Ong H, Masson JF. Modified peptide monolayer binding His-tagged biomolecules for small ligand screening with SPR biosensors. The Analyst. 136: 3142-8. PMID 21698315 DOI: 10.1039/C1An15235A |
0.712 |
|
| 2011 |
Sabatino D, Proulx C, Pohankova P, Ong H, Lubell WD. Structure-activity relationships of GHRP-6 azapeptide ligands of the CD36 scavenger receptor by solid-phase submonomer azapeptide synthesis. Journal of the American Chemical Society. 133: 12493-506. PMID 21692501 DOI: 10.1021/Ja203007U |
0.713 |
|
| 2011 |
Godina TA, Lubell WD. Mimics of peptide turn backbone and side-chain geometry by a general approach for modifying azabicyclo[5.3.0]alkanone amino acids. The Journal of Organic Chemistry. 76: 5846-9. PMID 21639101 DOI: 10.1021/Jo2006363 |
0.498 |
|
| 2011 |
Boutard N, Dufour-Gallant J, Deaudelin P, Lubell WD. Pyrrolo[3,2-e][1,4]diazepin-2-one synthesis: a head-to-head comparison of soluble versus insoluble supports. The Journal of Organic Chemistry. 76: 4533-45. PMID 21491955 DOI: 10.1021/Jo200424Q |
0.366 |
|
| 2011 |
Boutard N, Turcotte S, Beauregard K, Quiniou C, Chemtob S, Lubell WD. Examination of the active secondary structure of the peptide 101.10, an allosteric modulator of the interleukin-1 receptor, by positional scanning using β-amino γ-lactams. Journal of Peptide Science : An Official Publication of the European Peptide Society. 17: 288-96. PMID 21294228 DOI: 10.1002/Psc.1337 |
0.472 |
|
| 2010 |
Proulx C, Lubell WD. Aza-1,2,3-triazole-3-alanine synthesis via copper-catalyzed 1,3-dipolar cycloaddition on aza-progargylglycine. The Journal of Organic Chemistry. 75: 5385-7. PMID 20583744 DOI: 10.1021/Jo100957Z |
0.73 |
|
| 2010 |
Proulx C, Lubell WD. Copper-catalyzed N-arylation of semicarbazones for the synthesis of aza-arylglycine-containing aza-peptides. Organic Letters. 12: 2916-9. PMID 20536163 DOI: 10.1021/Ol100932M |
0.752 |
|
| 2010 |
Bourguet CB, Proulx C, Klocek S, Sabatino D, Lubell WD. Solution-phase submonomer diversification of aza-dipeptide building blocks and their application in aza-peptide and aza-DKP synthesis. Journal of Peptide Science : An Official Publication of the European Peptide Society. 16: 284-96. PMID 20474040 DOI: 10.1002/Psc.1235 |
0.736 |
|
| 2010 |
St-Cyr DJ, Jamieson AG, Lubell WD. alpha-Amino-beta-hydroxy-gamma-lactam for constraining peptide Ser and Thr residue conformation. Organic Letters. 12: 1652-5. PMID 20225885 DOI: 10.1021/Ol1000582 |
0.46 |
|
| 2010 |
Ronga L, Jamieson AG, Beauregard K, Quiniou C, Chemtob S, Lubell WD. Insertion of multiple alpha-amino gamma-lactam (Agl) residues into a peptide sequence by solid-phase synthesis on synphase lanterns. Biopolymers. 94: 183-91. PMID 20225301 DOI: 10.1002/Bip.21288 |
0.481 |
|
| 2010 |
Tong W, Gagnon M, Sprules T, Gilbert M, Chowdhury S, Meerovitch K, Hansford K, Purisima EO, Blankenship JW, Cheung NK, Gehring K, Lubell WD, Saragovi HU. Small-molecule ligands of GD2 ganglioside, designed from NMR studies, exhibit induced-fit binding and bioactivity. Chemistry & Biology. 17: 183-94. PMID 20189108 DOI: 10.1016/J.Chembiol.2010.01.012 |
0.343 |
|
| 2010 |
Boutard N, Jamieson AG, Ong H, Lubell WD. Structure-activity analysis of the growth hormone secretagogue GHRP-6 by alpha- and beta-amino gamma-lactam positional scanning. Chemical Biology & Drug Design. 75: 40-50. PMID 19954433 DOI: 10.1111/J.1747-0285.2009.00913.X |
0.428 |
|
| 2010 |
BEAUSOLEIL E, L'ARCHEVEQUE B, BELEC L, ATFANI M, LUBELL WD. ChemInform Abstract: 5-tert-Butylproline. Cheminform. 28: no-no. DOI: 10.1002/chin.199719213 |
0.758 |
|
| 2009 |
Sabatino D, Proulx C, Klocek S, Bourguet CB, Boeglin D, Ong H, Lubell WD. Exploring side-chain diversity by submonomer solid-phase aza-peptide synthesis. Organic Letters. 11: 3650-3. PMID 19606817 DOI: 10.1021/Ol901423C |
0.745 |
|
| 2009 |
Fridkin G, Boutard N, Lubell WD. Beta,beta-disubstituted C- and N-vinylindoles from one-step condensations of aldehydes and indole derivatives. The Journal of Organic Chemistry. 74: 5603-6. PMID 19496577 DOI: 10.1021/Jo900526P |
0.322 |
|
| 2009 |
Jamieson AG, Boutard N, Beauregard K, Bodas MS, Ong H, Quiniou C, Chemtob S, Lubell WD. Positional scanning for peptide secondary structure by systematic solid-phase synthesis of amino lactam peptides. Journal of the American Chemical Society. 131: 7917-27. PMID 19453183 DOI: 10.1021/Ja9010628 |
0.515 |
|
| 2009 |
Bourguet CB, Hou X, Chemtob S, Lubell WD. Exploring the relationship between turn geometry and allosteric antagonism of peptide mimic ligands for the prostaglandin F2alpha receptor Advances in Experimental Medicine and Biology. 611: 271-273. PMID 19400189 DOI: 10.1007/978-0-387-73657-0_122 |
0.391 |
|
| 2009 |
Dörr AA, Lubell WD. Synthesis and peptide coupling of protected pyrrolylalanine. Advances in Experimental Medicine and Biology. 611: 217-8. PMID 19400167 DOI: 10.1016/J.Tetlet.2010.11.089 |
0.474 |
|
| 2009 |
Iden HS, Lubell WD. Solid-phase synthesis of 1,3,5-trisubstituted 1,4-diazepin-2-one peptide mimic. Advances in Experimental Medicine and Biology. 611: 213-4. PMID 19400165 DOI: 10.1007/978-0-387-73657-0_98 |
0.419 |
|
| 2009 |
Lama T, Fridkin G, Lubell WD. Poly-(Prophi[Ch(OAc)CH2]Aib)3 a protected trimer of Pro-Aib hydroxyethylene isosteres. Advances in Experimental Medicine and Biology. 611: 171-2. PMID 19400145 DOI: 10.1007/978-0-387-73657-0_78 |
0.306 |
|
| 2009 |
Bourguet CB, Dörr A, Godina T, Proulx C, Fridkin G, Jamieson A, Sabatino D, Kassem T, Boutard N, Arsenault J, Ronga L, Brouillette Y, Bednarek M, Tolles JC, Lubell WD. Portraits of the pioneers of the American Peptide Society. Advances in Experimental Medicine and Biology. 611: xlix-lxix. PMID 19400064 |
0.658 |
|
| 2009 |
Kassem T, Sabatino D, Jia X, Zhu XX, Lubell WD. To Rink or Not to Rink Amide Link, that is the Question to Address for More Economical and Environmentally Sound Solid-Phase Peptide Synthesis International Journal of Peptide Research and Therapeutics. 15: 211-218. DOI: 10.1007/S10989-009-9177-0 |
0.424 |
|
| 2008 |
Bourguet CB, Sabatino D, Lubell WD. Benzophenone semicarbazone protection strategy for synthesis of aza-glycine containing aza-peptides. Biopolymers. 90: 824-31. PMID 18844293 DOI: 10.1002/Bip.21103 |
0.512 |
|
| 2008 |
Iden HS, Lubell WD. 1,3,5-Tri- and 1,3,4,5-tetra-substituted 1,4-diazepin-2-one solid-phase synthesis. Journal of Combinatorial Chemistry. 10: 691-9. PMID 18687008 DOI: 10.1021/Cc8001052 |
0.429 |
|
| 2008 |
Deaudelin P, Lubell WD. Diastereoselective Pictet-Spengler approach for the synthesis of pyrrolo[3,2-e][1,4]diazepin-2-one peptide turn mimics. Organic Letters. 10: 2841-4. PMID 18543989 DOI: 10.1021/Ol8009978 |
0.462 |
|
| 2008 |
Sajjadi Z, Lubell WD. Amino acid-azetidine chimeras: synthesis of enantiopure 3-substituted azetidine-2-carboxylic acids. Journal of Peptide Research. 65: 298-310. PMID 15705172 DOI: 10.1111/J.1399-3011.2005.00228.X |
0.477 |
|
| 2008 |
Galaud F, Blankenship JW, Lubell WD. Crystal structure analysis and reactivity of N-alkyl- and N-acyldioxathiazinanes Heterocycles. 76: 1121-1131. DOI: 10.3987/Com-08-S(N)69 |
0.411 |
|
| 2008 |
Jolicoeur B, Lubell WD. Prodigiosin synthesis with electron rich 2,2′-bipyrroles Canadian Journal of Chemistry. 86: 213-218. DOI: 10.1139/V07-150 |
0.327 |
|
| 2007 |
Iden HS, Lubell WD. 1,3,5-trisubstituted 1,4-diazepin-2-ones. The Journal of Organic Chemistry. 72: 8980-3. PMID 17927249 DOI: 10.1021/Jo701467D |
0.399 |
|
| 2007 |
Luo J, Pardin C, Zhu XX, Lubell WD. Preparation, characterization, and application of poly(vinyl alcohol)-graft-poly(ethylene glycol) resins: novel polymer matrices for solid-phase synthesis. Journal of Combinatorial Chemistry. 9: 582-91. PMID 17590052 DOI: 10.1021/Cc060132+ |
0.383 |
|
| 2007 |
Boeglin D, Hamdan FF, Melendez RE, Cluzeau J, Laperriere A, Héroux M, Bouvier M, Lubell WD. Calcitonin gene-related peptide analogues with aza and indolizidinone amino acid residues reveal conformational requirements for antagonist activity at the human calcitonin gene-related peptide 1 receptor. Journal of Medicinal Chemistry. 50: 1401-8. PMID 17319653 DOI: 10.1021/Jm061343W |
0.801 |
|
| 2007 |
Rao MH, Pinyol E, Lubell WD. Rigid dipeptide mimics: synthesis of enantiopure C6-functionalized pyrrolizidinone amino acids. The Journal of Organic Chemistry. 72: 736-43. PMID 17253788 DOI: 10.1021/Jo0616761 |
0.445 |
|
| 2007 |
Dörr A, Lubell WD. Synthesis of a new pi-deficient phenylalanine derivative from a common 1,4-diketone intermediate and study of the influence of aromatic density on prolyl amide isomer population. Biopolymers. 88: 290-9. PMID 17143857 DOI: 10.1002/Bip.20643 |
0.434 |
|
| 2007 |
Dörr AA, Lubell WD. Homoallylic ketones and pyrroles by way of copper-catalyzed cascade additions of alkyl-substituted vinyl Grignard reagents to esters Canadian Journal of Chemistry. 85: 1006-1017. DOI: 10.1139/V07-114 |
0.389 |
|
| 2007 |
Lama T, Del Valle SE, Genest N, Lubell WD. Alcohols as Replacements of the Central Amide in β-Turns, Synthesis of Pro-Aib Hydroxyethylene Isostere and Analysis in Model β-Turn Peptides International Journal of Peptide Research and Therapeutics. 13: 355-366. DOI: 10.1007/S10989-007-9093-0 |
0.405 |
|
| 2006 |
Jolicoeur B, Lubell WD. 4-alkoxy- and 4-amino-2,2'-bipyrrole synthesis. Organic Letters. 8: 6107-10. PMID 17165941 DOI: 10.1021/Ol0625583 |
0.39 |
|
| 2006 |
Iden HS, Lubell WD. 1,4-Diazepinone and pyrrolodiazepinone syntheses via homoallylic ketones from cascade addition of vinyl Grignard reagent to alpha-aminoacyl-beta-amino esters. Organic Letters. 8: 3425-8. PMID 16869626 DOI: 10.1021/Ol061036K |
0.397 |
|
| 2006 |
Surprenant S, Lubell WD. From macrocycle dipeptide lactams to azabicyclo[X.Y.0]alkanone amino acids: a transannular cyclization route for peptide mimic synthesis. Organic Letters. 8: 2851-4. PMID 16774273 DOI: 10.1021/Ol0609863 |
0.482 |
|
| 2006 |
Boeglin D, Xiang Z, Sorenson NB, Wood MS, Haskell-Luevano C, Lubell WD. Aza-scanning of the potent melanocortin receptor agonist Ac-His-D-Phe-Arg-Trp-NH. Chemical Biology & Drug Design. 67: 275-83. PMID 16629825 DOI: 10.1111/J.1747-0285.2006.00378.X |
0.495 |
|
| 2006 |
Surprenant S, Lubell WD. 9-(4-Bromophenyl)-9-fluorenyl as a safety-catch nitrogen protecting group. The Journal of Organic Chemistry. 71: 848-51. PMID 16409010 DOI: 10.1021/Jo0521910 |
0.333 |
|
| 2006 |
Brouillette Y, Rombouts FJ, Lubell WD. Solid-phase synthesis of 3-aminopyrrole-2,5-dicarboxylate analogues. Journal of Combinatorial Chemistry. 8: 117-26. PMID 16398562 DOI: 10.1021/Cc0500912 |
0.415 |
|
| 2005 |
Fridkin G, Lubell WD. Deazapurine solid-phase synthesis: combinatorial synthesis of a library of N3,N5,C6-trisubstituted pyrrolo[3,2-d]pyrimidine derivatives on cross-linked polystyrene bearing a cysteamine linker. Journal of Combinatorial Chemistry. 7: 977-86. PMID 16283810 DOI: 10.1021/Cc050003D |
0.387 |
|
| 2005 |
Boeglin D, Lubell WD. Aza-amino acid scanning of secondary structure suited for solid-phase peptide synthesis with fmoc chemistry and aza-amino acids with heteroatomic side chains. Journal of Combinatorial Chemistry. 7: 864-78. PMID 16283795 DOI: 10.1021/Cc050043H |
0.527 |
|
| 2005 |
Hansford KA, Perez Guarin SA, Skene WG, Lubell WD. Bis(pyrrol-2-yl)arylenes from the tandem bidirectional addition of vinyl Grignard reagent to aryl diesters. The Journal of Organic Chemistry. 70: 7996-8000. PMID 16277320 DOI: 10.1021/Jo0510888 |
0.344 |
|
| 2005 |
Rombouts FJ, Fridkin G, Lubell WD. Deazapurine solid-phase synthesis: construction of 3-substituted pyrrolo[3,2-d]pyrimidine-6-carboxylates on cross-linked polystyrene bearing a cysteamine linker. Journal of Combinatorial Chemistry. 7: 589-98. PMID 16004503 DOI: 10.1021/Cc050002L |
0.314 |
|
| 2005 |
Kaul R, Surprenant S, Lubell WD. Systematic study of the synthesis of macrocyclic dipeptide beta-turn mimics possessing 8-, 9-, and 10- membered rings by ring-closing metathesis. The Journal of Organic Chemistry. 70: 3838-44. PMID 15876068 DOI: 10.1021/Jo0477648 |
0.408 |
|
| 2005 |
Cluzeau J, Lubell WD. Design, synthesis, and application of azabicyclo[X.Y.0]alkanone amino acids as constrained dipeptide surrogates and peptide mimics. Biopolymers. 80: 98-150. PMID 15795926 DOI: 10.1002/Bip.20213 |
0.795 |
|
| 2005 |
Galaud F, Lubell WD. Homoserine-derived cyclic sulfamidate as chiral educt for the diversity-oriented synthesis of lactam-bridged dipeptides. Biopolymers. 80: 665-74. PMID 15791637 DOI: 10.1002/Bip.20223 |
0.516 |
|
| 2005 |
Bélec L, Blankenship JW, Lubell WD. Examination of structural characteristics of the potent oxytocin antagonists [dPen1,Pen6]-OT and [dPen1,Pen6, 5-tBuPro7]-OT by NMR, Raman, CD spectroscopy and molecular modeling. Journal of Peptide Science : An Official Publication of the European Peptide Society. 11: 365-78. PMID 15641022 DOI: 10.1002/Psc.637 |
0.576 |
|
| 2005 |
Dettwiler JE, Bélec L, Lubell WD. Synthesis and application of L-N-Boc-N-methyl-β-hydroxyvaline in the preparation of a depsipeptide Canadian Journal of Chemistry. 83: 793-800. DOI: 10.1139/V05-033 |
0.599 |
|
| 2004 |
Hansford KA, Zanzarova V, Dörr A, Lubell WD. Three-step solution-phase combinatorial access to 1,2-disubstituted and 1,2,5-trisubstituted pyrroles from carboxylic esters. Journal of Combinatorial Chemistry. 6: 893-8. PMID 15530115 DOI: 10.1021/Cc049904X |
0.359 |
|
| 2004 |
Jeannotte G, Lubell WD. Large structural modification with conserved conformation: analysis of delta(3)-fused aryl prolines in model beta-turns. Journal of the American Chemical Society. 126: 14334-5. PMID 15521735 DOI: 10.1021/Ja0471222 |
0.459 |
|
| 2004 |
Kaul R, Brouillette Y, Sajjadi Z, Hansford KA, Lubell WD. Selective tert-butyl ester deprotection in the presence of acid labile protecting groups with use of ZnBr2. The Journal of Organic Chemistry. 69: 6131-3. PMID 15373501 DOI: 10.1021/Jo0491206 |
0.411 |
|
| 2004 |
Gingras K, Avedissian H, Thouin E, Boulanger V, Essagian C, McKerracher L, Lubell WD. Synthesis and evaluation of 4-(1-aminoalkyl)-N-(4-pyridyl)cyclohexanecarboxamides as Rho kinase inhibitors and neurite outgrowth promoters. Bioorganic & Medicinal Chemistry Letters. 14: 4931-4. PMID 15341954 DOI: 10.1016/J.Bmcl.2004.07.025 |
0.333 |
|
| 2004 |
Jeannotte G, Lubell WD. Synthesis of fused heteroarylprolines and pyrrolopyrroles. The Journal of Organic Chemistry. 69: 4656-62. PMID 15230586 DOI: 10.1021/Jo049612I |
0.455 |
|
| 2004 |
Melendez RE, Lubell WD. Aza-amino acid scan for rapid identification of secondary structure based on the application of N-Boc-aza(1)-dipeptides in peptide synthesis. Journal of the American Chemical Society. 126: 6759-64. PMID 15161304 DOI: 10.1021/Ja039643F |
0.538 |
|
| 2004 |
Van Cauwenberghe S, Simonin F, Cluzeau J, Becker JA, Lubell WD, Tourwé D. Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2. Journal of Medicinal Chemistry. 47: 1864-7. PMID 15027881 DOI: 10.1021/Jm031034V |
0.733 |
|
| 2004 |
Cluzeau J, Lubell WD. Conformationally constrained dipeptide surrogates with aromatic side-chains: synthesis of 4-aryl indolizidin-9-one amino acids by conjugate addition to a common alpha,omega-diaminoazelate enone intermediate. The Journal of Organic Chemistry. 69: 1504-12. PMID 14987004 DOI: 10.1021/Jo0355855 |
0.766 |
|
| 2004 |
Dettwiler JE, Lubell WD. Diversity-oriented synthesis of enantiopure N-protected β, β-dialkylserines Canadian Journal of Chemistry. 82: 318-324. DOI: 10.1139/V03-193 |
0.331 |
|
| 2003 |
Hansford KA, Dettwiler JE, Lubell WD. One-pot synthesis of homoallylic ketones from the addition of vinyl grignard reagent to carboxylic esters. Organic Letters. 5: 4887-90. PMID 14653699 DOI: 10.1021/Ol0359822 |
0.392 |
|
| 2003 |
Dietrich E, Lubell WD. Efficient synthesis of enantiopure pyrrolizidinone amino acid. The Journal of Organic Chemistry. 68: 6988-96. PMID 12946139 DOI: 10.1021/Jo034739D |
0.509 |
|
| 2003 |
Marcotte FA, Rombouts FJ, Lubell WD. Diversity-oriented synthesis of functionalized pyrrolo[3,2-d]pyrimidines with variation of the pyrimidine ring nitrogen substituents. The Journal of Organic Chemistry. 68: 6984-7. PMID 12946138 DOI: 10.1021/Jo034684F |
0.387 |
|
| 2003 |
Dettwiler JE, Lubell WD. Serine as chiral educt for the practical synthesis of enantiopure N-protected beta-hydroxyvaline. The Journal of Organic Chemistry. 68: 177-9. PMID 12515478 DOI: 10.1021/Jo026260B |
0.311 |
|
| 2003 |
Meléndez RE, Lubell WD. Synthesis and reactivity of cyclic sulfamidites and sulfamidates Tetrahedron. 59: 2581-2616. DOI: 10.1016/S0040-4020(03)00284-9 |
0.35 |
|
| 2002 |
Halab L, Becker JA, Darula Z, Tourwé D, Kieffer BL, Simonin F, Lubell WD. Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist. Journal of Medicinal Chemistry. 45: 5353-7. PMID 12431062 DOI: 10.1021/Jm020078L |
0.81 |
|
| 2002 |
Roy S, Lombart HG, Lubell WD, Hancock RE, Farmer SW. Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S. The Journal of Peptide Research : Official Journal of the American Peptide Society. 60: 198-214. PMID 12366527 DOI: 10.1034/J.1399-3011.2002.21026.X |
0.503 |
|
| 2002 |
Miranda LP, Lubell WD, Halkes KM, Groth T, Grøtli M, Rademann J, Gotfredsen CH, Meldal M. SPOCC-194, a new high functional group density PEG-based resin for solid-phase organic synthesis. Journal of Combinatorial Chemistry. 4: 523-9. PMID 12217026 DOI: 10.1021/Cc020030T |
0.309 |
|
| 2002 |
Marcotte FA, Lubell WD. An effective new synthesis of 4-aminopyrrole-2-carboxylates. Organic Letters. 4: 2601-3. PMID 12123386 DOI: 10.1021/Ol0262690 |
0.423 |
|
| 2002 |
Halab L, Lubell WD. Effect of sequence on peptide geometry in 5-tert-butylprolyl type VI beta-turn mimics. Journal of the American Chemical Society. 124: 2474-84. PMID 11890796 DOI: 10.1021/Ja012442W |
0.818 |
|
| 2002 |
Atfani M, Wei L, Lubell WD. N-(9-(9-phenylfluorenyl))homoserine-derived cyclic sulfamidates: novel chiral educts for the synthesis of enantiopure gamma-substituted alpha-amino acids. Organic Letters. 3: 2965-8. PMID 11554819 DOI: 10.1021/Ol016225B |
0.403 |
|
| 2001 |
Bélec L, Maletinska L, Slaninová J, Lubell WD. The influence of steric interactions on the conformation and biology of oxytocin. Synthesis and analysis of penicillamine(6)-oxytocin and penicillamine(6)-5-tert-butylproline(7)-oxytocin analogs. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 263-73. PMID 11576333 DOI: 10.1034/J.1399-3011.2001.00932.X |
0.565 |
|
| 2001 |
Gosselin F, Tourwé D, Ceusters M, Meert T, Heylen L, Jurzak M, Lubell WD. Probing opioid receptor-ligand interactions by employment of indolizidin-9-one amino acid as a constrained Gly(2)-Gly(3) surrogate in a leucine-enkephalin mimic. The Journal of Peptide Research : Official Journal of the American Peptide Society. 57: 337-44. PMID 11328491 DOI: 10.1046/J.1397-002X.2000.00812.X |
0.716 |
|
| 2001 |
Feng Z, Lubell WD. Synthesis of enantiopure 7-[3-azidopyl]indolizidin-2-one amino acid. A constrained mimic of the peptide backbone geometry and heteroatomic side-chain functionality of the ala-lys dipeptide. The Journal of Organic Chemistry. 66: 1181-5. PMID 11312945 DOI: 10.1021/Jo001252L |
0.489 |
|
| 2001 |
Polyak F, Lubell WD. Mimicry of peptide backbone geometry and heteroatomic side-chain functionality: synthesis of enantiopure indolizidin-2-one amino acids possessing alcohol, acid, and azide functional groups. The Journal of Organic Chemistry. 66: 1171-80. PMID 11312944 DOI: 10.1021/Jo001251T |
0.423 |
|
| 2001 |
Cluzeau J, Lubell WD. Remarkable asymmetric induction from remote stereocenters in conjugate addition chemistry for the synthesis of alkyl-branched α, ω-diaminoazelates Israel Journal of Chemistry. 41: 271-282. DOI: 10.1560/E1Uk-Etwj-Wlmf-Nha2 |
0.776 |
|
| 2001 |
Wei L, Lubell WD. Scope and limitations in the use of N-(PhF)serine-derived cyclic sulfamidates for amino acid synthesis Canadian Journal of Chemistry. 79: 94-104. DOI: 10.1139/V00-176 |
0.398 |
|
| 2001 |
Halab L, Bélec L, Lubell WD. Improved synthesis of (2S,5S)-5-tert-butylproline Tetrahedron. 57: 6439-6446. DOI: 10.1016/S0040-4020(01)00535-X |
0.795 |
|
| 2000 |
Khiat A, Fournier A, Lubell W, Boulanger Y. Conformational analysis of endothelin-1 analogs with indolizidinone amino acids incorporated at the C-terminus. Journal of Cardiovascular Pharmacology. 36. PMID 11078329 DOI: 10.1097/00005344-200036051-00013 |
0.54 |
|
| 2000 |
Halab L, Gosselin F, Lubell WD. Design, synthesis, and conformational analysis of azacycloalkane amino acids as conformationally constrained probes for mimicry of peptide secondary structures. Biopolymers. 55: 101-22. PMID 11074409 DOI: 10.1002/1097-0282(2000)55:2<101::Aid-Bip20>3.0.Co;2-O |
0.814 |
|
| 2000 |
Wei L, Lubell WD. Racemization in the use of N-(9-(9-phenylfluorenyl))serine-derived cyclic sulfamidates in the synthesis of delta-keto alpha-amino carboxylates and prolines. Organic Letters. 2: 2595-8. PMID 10990405 DOI: 10.1021/Ol006102B |
0.406 |
|
| 2000 |
Swarbrick ME, Lubell WD. Stereoconvergent approach for synthesizing enantiopure 5,6‐dialkylpipecolic acids Chirality. 12: 366-373. PMID 10824154 DOI: 10.1002/(Sici)1520-636X(2000)12:5/6<366::Aid-Chir12>3.0.Co;2-E |
0.409 |
|
| 2000 |
Bélec L, Slaninova J, Lubell WD. A study of the relationship between biological activity and prolyl amide isomer geometry in oxytocin using 5-tert-butylproline to augment the Cys(6)-Pro(7) amide cis-isomer population. Journal of Medicinal Chemistry. 43: 1448-55. PMID 10780900 DOI: 10.1021/Jm990090M |
0.585 |
|
| 2000 |
Gosselin F, Lubell WD. Rigid dipeptide surrogates: syntheses of enantiopure quinolizidinone and pyrroloazepinone amino acids from a common diaminodicarboxylate precursor. The Journal of Organic Chemistry. 65: 2163-71. PMID 10774041 DOI: 10.1021/Jo991766O |
0.713 |
|
| 2000 |
Beausoleil E, Lubell WD. An examination of the steric effects of 5-tert-butylproline on the conformation of polyproline and the cooperative nature of type II to type I helical interconversion. Biopolymers. 53: 249-56. PMID 10679629 DOI: 10.1002/(Sici)1097-0282(200003)53:3<249::Aid-Bip4>3.0.Co;2-J |
0.802 |
|
| 2000 |
Groth T, Grøtli M, Lubell WD, Miranda LP, Meldal M. HYDRA: A novel hydroxy and amine functionalised resin synthesised by reductive amination of PEG aldehyde and a polyamine Journal of the Chemical Society-Perkin Transactions 1. 4258-4264. DOI: 10.1039/B007141M |
0.335 |
|
| 2000 |
Thouin E, Lubell WD. Effective synthesis of enantiopure hydroxamates by displacement of resin-bound esters with hydroxylamine Tetrahedron Letters. 41: 457-460. DOI: 10.1016/S0040-4039(99)02092-4 |
0.382 |
|
| 1999 |
Halab L, Lubell WD. Use of Steric Interactions To Control Peptide Turn Geometry. Synthesis of Type VI beta-Turn Mimics with 5-tert-Butylproline. The Journal of Organic Chemistry. 64: 3312-3321. PMID 11674436 DOI: 10.1021/Jo990294A |
0.819 |
|
| 1999 |
Swarbrick ME, Gosselin F, Lubell WD. Alkyl Substituent Effects on Pipecolyl Amide Isomer Equilibrium: Efficient Methodology for Synthesizing Enantiopure 6-Alkylpipecolic Acids and Conformational Analysis of Their N-Acetyl N'-Methylamides. The Journal of Organic Chemistry. 64: 1993-2002. PMID 11674294 DOI: 10.1021/Jo982181H |
0.701 |
|
| 1999 |
Gosselin F, Van Betsbrugge J, Hatam M, Lubell WD. A Novel Linking-Protecting Group Strategy for Solid-Phase Organic Chemistry with Configurationally Stable α-[N-(Phenylfluorenyl)]amino Carbonyl Compounds: Synthesis of Enantiopure Norephedrines on Solid Support The Journal of Organic Chemistry. 64: 2486-2493. DOI: 10.1021/Jo982413C |
0.67 |
|
| 1998 |
Gosselin F, Lubell WD. An Olefination Entry for the Synthesis of Enantiopure alpha,omega-Diaminodicarboxylates and Azabicyclo[X.Y.0]alkane Amino Acids. The Journal of Organic Chemistry. 63: 7463-7471. PMID 11672399 DOI: 10.1021/Jo9814602 |
0.693 |
|
| 1998 |
Polyak F, Lubell WD. Rigid Dipeptide Mimics: Synthesis of Enantiopure 5- and 7-Benzyl and 5,7-Dibenzyl Indolizidinone Amino Acids via Enolization and Alkylation of delta-Oxo alpha,omega-Di-[N-(9-(9-phenylfluorenyl))amino]azelate Esters. The Journal of Organic Chemistry. 63: 5937-5949. PMID 11672198 DOI: 10.1021/Jo980596X |
0.515 |
|
| 1998 |
Beausoleil E, Sharma R, Michnick SW, Lubell WD. Alkyl 3-Position Substituents Retard the Isomerization of Prolyl and Hydroxyprolyl Amides in Water The Journal of Organic Chemistry. 63: 6572-6578. DOI: 10.1021/jo980673o |
0.762 |
|
| 1998 |
Beausoleil E, Sharma R, Michnick SW, Lubell WD. Alkyl 3-Position Substituents Retard the Isomerization of Prolyl and Hydroxyprolyl Amides in Water Journal of Organic Chemistry. 63: 6572-6578. DOI: 10.1021/Jo980673O |
0.813 |
|
| 1997 |
Hanessian S, McNaughton-Smith G, Lombart H, Lubell WD. Design and synthesis of conformationally constrained amino acids as versatile scaffolds and peptide mimetics Tetrahedron. 53: 12789-12854. DOI: 10.1016/S0040-4020(97)00476-6 |
0.464 |
|
| 1996 |
Gosselin F, Di Renzo M, Ellis TH, Lubell WD. Photoacoustic FTIR Spectroscopy, a Nondestructive Method for Sensitive Analysis of Solid-Phase Organic Chemistry. The Journal of Organic Chemistry. 61: 7980-7981. PMID 11667768 DOI: 10.1021/Jo961393G |
0.575 |
|
| 1996 |
Beausoleil E, L'Archevêque B, Bélec L, Atfani M, Lubell WD. 5-tert-Butylproline The Journal of Organic Chemistry. 61: 9447-9454. DOI: 10.1021/Jo9618738 |
0.798 |
|
| 1996 |
Lombart H, Lubell WD. Rigid Dipeptide Mimetics: Efficient Synthesis of Enantiopure Indolizidinone Amino Acids Journal of Organic Chemistry. 61: 9437-9446. DOI: 10.1021/Jo961872F |
0.47 |
|
| 1996 |
Sharma R, Lubell WD. Regioselective Enolization and Alkylation of 4-Oxo-N-(9-phenylfluoren-9-yl)proline: Synthesis of Enantiopure Proline−Valine and Hydroxyproline−Valine Chimeras Journal of Organic Chemistry. 61: 202-209. DOI: 10.1021/Jo9514984 |
0.422 |
|
| 1996 |
Beausoleil E, Lubell WD. Steric Effects on the Amide Isomer Equilibrium of Prolyl Peptides. Synthesis and Conformational Analysis ofN-Acetyl-5-tert-butylprolineN‘-Methylamides Journal of the American Chemical Society. 118: 12902-12908. DOI: 10.1021/Ja962013B |
0.822 |
|
| 1995 |
Atfani M, Lubell WD. Synthesis Of (S)-2-Amino-3-(3-Tert-Butyl-5-Oxo-2H-Isoxazol-4-Yl)Propionic Acid Journal of Organic Chemistry. 60: 3184-3188. DOI: 10.1021/Jo00115A039 |
0.378 |
|
| 1995 |
Gill P, Lubell WD. Synthesis of Enantiopure Arylkainoids: Preparation of (2S)-.DELTA.3-4-Phenylkainic Acid Journal of Organic Chemistry. 60: 2658-2659. DOI: 10.1021/Jo00114A007 |
0.381 |
|
| 1995 |
Kitamura M, Tokunaga M, Pham T, Lubell WD, Noyori R. Asymmetric synthesis of α-amino β-hydroxy phosphonic acids via BINAP-ruthenium catalyzed hydrogenation Tetrahedron Letters. 36: 5769-5772. DOI: 10.1016/0040-4039(95)01135-5 |
0.481 |
|
| 1994 |
Lombart H, Lubell WD. Synthesis of Enantiopure .alpha.,.omega.-Diamino Dicarboxylates and Azabicycloalkane Amino Acids by Claisen Condensation of .alpha.-[N-(Phenylfluorenyl)amino] Dicarboxylates The Journal of Organic Chemistry. 59: 6147-6149. DOI: 10.1021/Jo00100A008 |
0.351 |
|
| 1993 |
Ibrahim HH, Lubell WD. Synthesis of enantiopure .delta.-oxo .alpha.-amino esters and prolines via acylation of N-(phenylfluorenyl)glutamate enolates Journal of Organic Chemistry. 58: 6438-6441. DOI: 10.1021/Jo00075A046 |
0.443 |
|
| 1990 |
Lubell WD, Jamison TF, Rapoport H. N-(9-phenylfluoren-9-yl)-α-amino ketones and N-(9-phenylfluoren-9-yl)-α-amino aldehydes as chiral educts for the synthesis of optically pure 4-alkyl-3-hydroxy-2-amino acids. Synthesis of the C-9 amino acid MeBmt present in cyclosporin Journal of Organic Chemistry. 55: 3511-3522. DOI: 10.1021/Jo00298A025 |
0.564 |
|
| 1989 |
Lubell W, Rapoport H. Surrogates for chiral aminomalondialdehyde. Synthesis of N-(9-phenylfluoren-9-yl)serinal and N-(9-phenylfluoren-9-yl)vinylglycinal The Journal of Organic Chemistry. 54: 3824-3831. DOI: 10.1021/Jo00277A016 |
0.522 |
|
| 1988 |
Lubell WD, Rapoport H. .alpha.-Amino acids as chiral educts for asymmetric products. Alkylation of N-phenylfluorenyl .alpha.-amino ketones. Synthesis of optically pure .alpha.-alkyl carboxylic acids Journal of the American Chemical Society. 110: 7447-7455. DOI: 10.1021/Ja00230A027 |
0.514 |
|
| 1987 |
Lubell WD, Rapoport H. Configurational stability of N-protected .alpha.-amino aldehydes Journal of the American Chemical Society. 109: 236-239. DOI: 10.1021/Ja00235A035 |
0.541 |
|
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