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Timothy J. Jorgensen - Publications

Affiliations: 
Georgetown University Medical Center, Washington, DC, United States 
Area:
Biochemistry, Molecular Biology, Oncology
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Yoo SS, Jorgensen TJ, Kennedy AR, Boice JD, Shapiro A, Hu TC, Moyer BR, Grace MB, Kelloff GJ, Fenech M, Prasanna PG, Coleman CN. Mitigating the risk of radiation-induced cancers: limitations and paradigms in drug development. Journal of Radiological Protection : Official Journal of the Society For Radiological Protection. 34: R25-52. PMID 24727460 DOI: 10.1088/0952-4746/34/2/R25  0.311
2013 Alberg AJ, Jorgensen TJ, Ruczinski I, Wheless L, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Smith MW, Strickland PT. DNA repair gene variants in relation to overall cancer risk: a population-based study. Carcinogenesis. 34: 86-92. PMID 23027618 DOI: 10.1093/Carcin/Bgs304  0.425
2012 Jorgensen TJ, Ruczinski I, Yao Shugart Y, Wheless L, Berthier Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of hedgehog pathway gene variants in relation to the dual risk of basal cell carcinoma plus another cancer. Cancer Epidemiology. 36: e288-93. PMID 22677152 DOI: 10.1016/J.Canep.2012.05.001  0.313
2012 Ruczinski I, Jorgensen TJ, Shugart YY, Schaad YB, Kessing B, Hoffman-Bolton J, Helzlsouer KJ, Kao WH, Wheless L, Francis L, Alani RM, Strickland PT, Smith MW, Alberg AJ. A population-based study of DNA repair gene variants in relation to non-melanoma skin cancer as a marker of a cancer-prone phenotype. Carcinogenesis. 33: 1692-8. PMID 22581838 DOI: 10.1093/Carcin/Bgs170  0.443
2012 Wheless L, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Francis L, Shugart YY, Strickland PT, Kao WH, Alani RM, Smith MW, Alberg AJ. A community-based study of nucleotide excision repair polymorphisms in relation to the risk of non-melanoma skin cancer. The Journal of Investigative Dermatology. 132: 1354-62. PMID 22336945 DOI: 10.1038/Jid.2012.4  0.339
2012 Wheless LE, Kistner-Griffin E, Jorgensen TJ, Ruczinski I, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Woodward L, Yao Y, Strickland PT, Kao WHL, Alani RM, Smith MW, Alberg AJ. Abstract 2639: A community-based study of nucleotide excision repair polymorphisms in relation to risk of non-melanoma skin cancer Cancer Research. 72: 2639-2639. DOI: 10.1158/1538-7445.Am2012-2639  0.348
2012 Ruczinski I, Jorgensen T, Shugart YY, Berthier-Schaad Y, Kessing B, Hoffman-Bolton J, Helzlsouer K, Kao WHL, Wheless L, Francis L, Alani R, Strickland P, Smith M, Alberg AJ. Abstract 2636: Nonmelanoma skin cancer as a marker of a cancer-prone phenotype: Potential role of DNA repair gene variants Cancer Research. 72: 2636-2636. DOI: 10.1158/1538-7445.Am2012-2636  0.405
2011 Shen GP, Pan QH, Hong MH, Qin HD, Xu YF, Chen LZ, Feng QS, Jorgensen TJ, Shugart YY, Zeng YX, Jia WH. Human genetic variants of homologous recombination repair genes first found to be associated with Epstein-Barr virus antibody titers in healthy Cantonese. International Journal of Cancer. 129: 1459-66. PMID 21792882 DOI: 10.1002/Ijc.25759  0.323
2011 Qin HD, Shugart YY, Bei JX, Pan QH, Chen L, Feng QS, Chen LZ, Huang W, Liu JJ, Jorgensen TJ, Zeng YX, Jia WH. Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma. Cancer Research. 71: 3000-8. PMID 21368091 DOI: 10.1158/0008-5472.Can-10-0469  0.448
2009 Jorgensen TJ, Ruczinski I, Kessing B, Smith MW, Shugart YY, Alberg AJ. Hypothesis-driven candidate gene association studies: practical design and analytical considerations. American Journal of Epidemiology. 170: 986-93. PMID 19762372 DOI: 10.1093/Aje/Kwp242  0.305
2009 Tse KP, Su WH, Chang KP, Tsang NM, Yu CJ, Tang P, See LC, Hsueh C, Yang ML, Hao SP, Li HY, Wang MH, Liao LP, Chen LC, Lin SR, ... Jorgensen TJ, et al. Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. American Journal of Human Genetics. 85: 194-203. PMID 19664746 DOI: 10.1016/J.Ajhg.2009.07.007  0.316
2009 Jorgensen TJ, Chen K, Chasovskikh S, Roy R, Dritschilo A, Uren A. Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates. Journal of Molecular Recognition : Jmr. 22: 446-52. PMID 19585541 DOI: 10.1002/Jmr.962  0.419
2009 Jorgensen TJ. Enhancing radiosensitivity: targeting the DNA repair pathways. Cancer Biology & Therapy. 8: 665-70. PMID 19287209 DOI: 10.4161/Cbt.8.8.8304  0.45
2009 Jorgensen TJ, Helzlsouer KJ, Clipp SC, Bolton JH, Crum RM, Visvanathan K. DNA repair gene variants associated with benign breast disease in high cancer risk women Cancer Epidemiology Biomarkers and Prevention. 18: 346-350. PMID 19124519 DOI: 10.1158/1055-9965.Epi-08-0659  0.391
2008 Jorgensen T, Helzlsouer K, Hoffman S, Hoffman-Bolton J, Crum R, Visvanathan K. Abstract A75: DNA repair genotypes associated with benign breast disease in women at high breast cancer risk Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-A75  0.405
2007 Jorgensen TJ, Visvanathan K, Ruczinski I, Thuita L, Hoffman S, Helzlsouer KJ. Breast cancer risk is not associated with polymorphic forms of xeroderma pigmentosum genes in a cohort of women from Washington County, Maryland Breast Cancer Research and Treatment. 101: 65-71. PMID 16823510 DOI: 10.1007/S10549-006-9263-3  0.354
2006 Crowe SL, Movsesyan VA, Jorgensen TJ, Kondratyev A. Rapid phosphorylation of histone H2A.X following ionotropic glutamate receptor activation. The European Journal of Neuroscience. 23: 2351-61. PMID 16706843 DOI: 10.1111/J.1460-9568.2006.04768.X  0.35
2006 Brewster AM, Jorgensen TJ, Ruczinski I, Huang HY, Hoffman S, Thuita L, Newschaffer C, Lunn RM, Bell D, Helzlsouer KJ. Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): Relationship to breast cancer risk and familial predisposition to breast cancer Breast Cancer Research and Treatment. 95: 73-80. PMID 16319991 DOI: 10.1007/S10549-005-9045-3  0.336
2002 Tian H, Faje AT, Lee SL, Jorgensen TJ. Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways. Neoplasia (New York, N.Y.). 4: 171-80. PMID 11896572 DOI: 10.1038/Sj.Neo.7900219  0.429
1999 Kohli M, Jorgensen TJ. Lack of dependence on p53 for DNA double strand break repair of episomal vectors in human lymphoblasts. Biochemical and Biophysical Research Communications. 264: 702-8. PMID 10543995 DOI: 10.1006/Bbrc.1999.1575  0.707
1999 Winters TA, Russell PS, Kohli M, Dar ME, Neumann RD, Jorgensen TJ. Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate. Nucleic Acids Research. 27: 2423-33. PMID 10325434 DOI: 10.1093/Nar/27.11.2423  0.693
1999 Kohli M, Jorgensen TJ. The influence of SV40 immortalization of human fibroblasts on p53-dependent radiation responses. Biochemical and Biophysical Research Communications. 257: 168-76. PMID 10092528 DOI: 10.1006/Bbrc.1999.0389  0.679
1997 Dar ME, Winters TA, Jorgensen TJ. Identification of defective illegitimate recombinational repair of oxidatively-induced DNA double-strand breaks in ataxia-telangiectasia cells. Mutation Research. 384: 169-79. PMID 9330613 DOI: 10.1016/S0921-8777(97)00021-9  0.428
1997 Ziv Y, Bar-Shira A, Pecker I, Russell P, Jorgensen TJ, Tsarfati I, Shiloh Y. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene. 15: 159-67. PMID 9244351 DOI: 10.1038/Sj.Onc.1201319  0.358
1996 Gilad S, Khosravi R, Shkedy D, Uziel T, Ziv Y, Savitsky K, Rotman G, Smith S, Chessa L, Jorgensen TJ, Harnik R, Frydman M, Sanal O, Portnoi S, Goldwicz Z, et al. Predominance of null mutations in ataxia-telangiectasia. Human Molecular Genetics. 5: 433-9. PMID 8845835 DOI: 10.1093/Hmg/5.4.433  0.307
1995 Ziv Y, Bar-Shira A, Jorgensen TJ, Russell PS, Sartiel A, Shows TB, Eddy RL, Buchwald M, Legerski R, Schimke RT, Shiloh Y. Human cDNA clones that modify radiomimetic sensitivity of ataxia-telangiectasia (group A) cells. Somatic Cell and Molecular Genetics. 21: 99-111. PMID 7570189 DOI: 10.1007/Bf02255785  0.37
1995 Dar ME, Jorgensen TJ. Deletions at short direct repeats and base substitutions are characteristic mutations for bleomycin-induced double- and single-strand breaks, respectively, in a human shuttle vector system. Nucleic Acids Research. 23: 3224-30. PMID 7545284 DOI: 10.1093/Nar/23.16.3224  0.464
1995 Jorgensen TJ, Russell PS, McRae DA. Radioresistant DNA Synthesis in SV40-Immortalized Ataxia Telangiectasia Fibroblasts Radiation Research. 143: 219. DOI: 10.2307/3579160  0.489
1994 Winters TA, Henner WD, Russell PS, McCullough A, Jorgensen TJ. Removal of 3′-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1 Nucleic Acids Research. 22: 1866-1873. PMID 7516064 DOI: 10.1093/Nar/22.10.1866  0.459
1993 Jorgensen TJ, Notario V, Thraves PJ, Dritschilo A. Radiation response of NIH/3T3 mouse fibroblasts overexpressing human poly(adenosine diphosphate ribose) polymerase Radiation Oncology Investigations. 1: 189-197. DOI: 10.1002/Roi.2970010402  0.405
1992 Winters TA, Weinfeld M, Jorgensen TJ. Human HeLa cell enzymes that remove phosphoglycolate 3'-end groups from DNA. Nucleic Acids Research. 20: 2573-2580. PMID 1375993 DOI: 10.1093/Nar/20.10.2573  0.408
1992 Buatti JM, Rivero LR, Jorgensen TJ. Radiation-Induced DNA Single-Strand Breaks in Freshly Isolated Human Leukocytes Radiation Research. 132: 200. DOI: 10.2307/3578527  0.497
1991 Oudard S, Thierry A, Jorgensen TJ, Rahman A. Sensitization of multidrug-resistant colon cancer cells to doxorubicin encapsulated in liposomes. Cancer Chemotherapy and Pharmacology. 28: 259-65. PMID 1678995 DOI: 10.1007/Bf00685532  0.35
1991 Jorgensen TJ, Leonard JC, Thraves PJ, Dritschilo A. Baseline Sister Chromatid Exchange in Human Cell Lines with Different Levels of Poly(ADP-Ribose) Polymerase Radiation Research. 127: 107. DOI: 10.2307/3578096  0.395
1990 Jorgensen TJ, Prasad SC, Brennan TP, Dritschilo A. Constraints to DNA Unwinding near Radiation-Induced Strand Breaks in Ewing's Sarcoma Cells Radiation Research. 123: 320. DOI: 10.2307/3577739  0.473
1987 Jorgensen TJ, Olive PL, Durand RE. DNA strand breakage in Chinese hamster V79 cells caused by low levels of incorporated [3H] and [14C]thymidine. International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine. 51: 673-80. PMID 3495511 DOI: 10.1080/09553008414552201  0.361
1986 Furlong EA, Jorgensen TJ, Henner WD. Production of dihydrothymidine stereoisomers in DNA by gamma-irradiation. Biochemistry. 25: 4344-4349. PMID 3756143 DOI: 10.1021/Bi00363A025  0.425
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