Luis de Lecea - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Sleep, hypocretin, hypothalamus, addiction

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Li SB, de Lecea L. The brake matters: Hyperexcitable arousal circuits in sleep fragmentation with age. Clinical and Translational Medicine. 12: e900. PMID 35696605 DOI: 10.1002/ctm2.900  0.773
2022 Bian WJ, Brewer CL, Kauer JA, de Lecea L. Adolescent sleep shapes social novelty preference in mice. Nature Neuroscience. PMID 35618950 DOI: 10.1038/s41593-022-01076-8  0.792
2022 Li SB, Damonte VM, Chen C, Wang GX, Kebschull JM, Yamaguchi H, Bian WJ, Purmann C, Pattni R, Urban AE, Mourrain P, Kauer JA, Scherrer G, de Lecea L. Hyperexcitable arousal circuits drive sleep instability during aging. Science (New York, N.Y.). 375: eabh3021. PMID 35201886 DOI: 10.1126/science.abh3021  0.839
2022 Owens-French J, Li SB, Francois M, Leigh Townsend R, Daniel M, Soulier H, Turner A, de Lecea L, Münzberg H, Morrison C, Qualls-Creekmore E. Lateral hypothalamic galanin neurons are activated by stress and blunt anxiety-like behavior in mice. Behavioural Brain Research. 423: 113773. PMID 35101456 DOI: 10.1016/j.bbr.2022.113773  0.774
2022 Jacobson LH, Hoyer D, de Lecea L. Hypocretins (orexins): The ultimate translational neuropeptides. Journal of Internal Medicine. PMID 35043499 DOI: 10.1111/joim.13406  0.376
2021 Sagi D, de Lecea L, Appelbaum L. Heterogeneity of Hypocretin/Orexin Neurons. Frontiers of Neurology and Neuroscience. 45: 61-74. PMID 34052814 DOI: 10.1159/000514964  0.398
2021 de Lecea L. Twenty-Three Years of Hypocretins: The "Rosetta Stone" of Sleep/Arousal Circuits. Frontiers of Neurology and Neuroscience. 45: 1-10. PMID 34052811 DOI: 10.1159/000514961  0.35
2021 Borniger JC, de Lecea L. Peripheral Lipopolyssacharide Rapidly Silences REM-Active LH Neurons. Frontiers in Behavioral Neuroscience. 15: 649428. PMID 33716686 DOI: 10.3389/fnbeh.2021.649428  0.776
2020 Dorsey A, de Lecea L, Jennings KJ. Neurobiological and Hormonal Mechanisms Regulating Women's Sleep. Frontiers in Neuroscience. 14: 625397. PMID 33519372 DOI: 10.3389/fnins.2020.625397  0.611
2020 Li SB, Borniger JC, Yamaguchi H, Hédou J, Gaudilliere B, de Lecea L. Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression. Science Advances. 6. PMID 32917689 DOI: 10.1126/Sciadv.Abc2590  0.815
2020 Jennings KJ, de Lecea L. Neural and Hormonal Control of Sexual Behavior. Endocrinology. PMID 32845294 DOI: 10.1210/Endocr/Bqaa150  0.501
2020 Li P, Li SB, Wang X, Phillips CD, Schwarz LA, Luo L, de Lecea L, Krasnow MA. Brain Circuit of Claustrophobia-like Behavior in Mice Identified by Upstream Tracing of Sighing. Cell Reports. 31: 107779. PMID 32553161 DOI: 10.1016/J.Celrep.2020.107779  0.785
2020 Li SB, de Lecea L. The hypocretin (orexin) system: from a neural circuitry perspective. Neuropharmacology. 167: 107993. PMID 32135427 DOI: 10.1016/J.Neuropharm.2020.107993  0.801
2020 Eban-Rothschild A, Borniger JC, Rothschild G, Giardino WJ, Morrow JG, de Lecea L. Arousal-state dependent alterations in VTA-GABAergic neuronal activity. Eneuro. PMID 32054621 DOI: 10.1523/ENEURO.0356-19.2020  0.843
2019 Yamaguchi H, de Lecea L. Construction of Viral Vectors for Cell Type-specific CRISPR Gene Editing in the Adult Mouse Brain. Bio-Protocol. 9: e3334. PMID 33654839 DOI: 10.21769/BioProtoc.3334  0.436
2018 Yamaguchi H, Hopf FW, Li SB, de Lecea L. In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nature Communications. 9: 5211. PMID 30523254 DOI: 10.1038/S41467-018-07566-3  0.817
2018 Yamaguchi H, de Lecea L. In vivo cell type-specific CRISPR gene editing for sleep research. Journal of Neuroscience Methods. PMID 30439390 DOI: 10.1016/J.Jneumeth.2018.10.016  0.579
2018 Nevárez N, de Lecea L. Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation. F1000research. 7. PMID 30254737 DOI: 10.12688/F1000Research.15097.1  0.819
2018 Li SB, Nevárez N, Giardino WJ, de Lecea L. Optical Probing of Orexin/Hypocretin Receptor Antagonists. Sleep. PMID 30060151 DOI: 10.1093/Sleep/Zsy141  0.781
2018 Giardino WJ, Eban-Rothschild A, Christoffel DJ, Li SB, Malenka RC, de Lecea L. Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states. Nature Neuroscience. 21: 1084-1095. PMID 30038273 DOI: 10.1038/S41593-018-0198-X  0.817
2018 Tyree SM, Borniger JC, de Lecea L. Hypocretin as a Hub for Arousal and Motivation. Frontiers in Neurology. 9: 413. PMID 29928253 DOI: 10.3389/Fneur.2018.00413  0.84
2018 Steiner N, Rossetti C, Sakurai T, Yanagisawa M, de Lecea L, Magistretti PJ, Halfon O, Boutrel B. Hypocretin/orexin deficiency decreases cocaine abuse liability. Neuropharmacology. PMID 29454841 DOI: 10.1016/J.Neuropharm.2018.02.010  0.68
2017 Eban-Rothschild A, Appelbaum L, de Lecea L. Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29206811 DOI: 10.1038/Npp.2017.294  0.823
2017 Fujita A, Bonnavion P, Wilson MH, Mickelsen LE, Bloit J, de Lecea L, Jackson AC. Hypothalamic tuberomammillary nucleus neurons: electrophysiological diversity and essential role in arousal stability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28874450 DOI: 10.1523/Jneurosci.0580-17.2017  0.818
2017 Tyree SM, de Lecea L. Optogenetic Investigation of Arousal Circuits. International Journal of Molecular Sciences. 18. PMID 28809797 DOI: 10.3390/Ijms18081773  0.842
2017 Tyree SM, de Lecea L. Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior. Frontiers in Systems Neuroscience. 11: 50. PMID 28729827 DOI: 10.3389/Fnsys.2017.00050  0.823
2017 Eban-Rothschild A, Giardino WJ, de Lecea L. To sleep or not to sleep: neuronal and ecological insights. Current Opinion in Neurobiology. 44: 132-138. PMID 28500869 DOI: 10.1016/J.Conb.2017.04.010  0.839
2017 Eban-Rothschild A, de Lecea L. Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states. F1000research. 6: 212. PMID 28357049 DOI: 10.12688/F1000Research.9677.1  0.815
2016 Li SB, Giardino WJ, de Lecea L. Hypocretins and Arousal. Current Topics in Behavioral Neurosciences. PMID 28012091 DOI: 10.1007/7854_2016_58  0.843
2016 Eban-Rothschild A, Rothschild G, Giardino WJ, Jones JR, de Lecea L. VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors. Nature Neuroscience. PMID 27595385 DOI: 10.1038/Nn.4377  0.851
2016 Castellano JM, Palner M, Li SB, Freeman GM, Nguyen A, Shen B, Stan T, Mosher KI, Chin FT, de Lecea L, Luo J, Wyss-Coray T. In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model. Scientific Reports. 6: 29015. PMID 27364522 DOI: 10.1038/Srep29015  0.744
2016 Bonnavion P, Mickelsen L, Fujita A, de Lecea L, Jackson AC. Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour. The Journal of Physiology. PMID 27302606 DOI: 10.1113/Jp271946  0.774
2016 Li SB, Jones JR, de Lecea L. Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders. Current Psychiatry Reports. 18: 7. PMID 26733323 DOI: 10.1007/S11920-015-0639-0  0.779
2015 Giardino WJ, de Lecea L. Resting easy with a sleep regulator. Elife. 4. PMID 26651823 DOI: 10.7554/eLife.12093  0.789
2015 Rolls A, Pang WW, Ibarra I, Colas D, Bonnavion P, Korin B, Heller HC, Weissman IL, de Lecea L. Sleep disruption impairs haematopoietic stem cell transplantation in mice. Nature Communications. 6: 8516. PMID 26465715 DOI: 10.1038/Ncomms9516  0.818
2015 Zhang F, Tsai HC, Airan RD, Stuber GD, Adamantidis AR, de Lecea L, Bonci A, Deisseroth K. Optogenetics in Freely Moving Mammals: Dopamine and Reward. Cold Spring Harbor Protocols. 2015: pdb.top086330. PMID 26240415 DOI: 10.1101/Pdb.Top086330  0.685
2015 Sorooshyari S, Huerta R, de Lecea L. A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition. Frontiers in Neurology. 6: 32. PMID 25767461 DOI: 10.3389/fneur.2015.00032  0.396
2015 Bonnavion P, Jackson AC, Carter ME, de Lecea L. Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. Nature Communications. 6: 6266. PMID 25695914 DOI: 10.1038/Ncomms7266  0.8
2015 de Lecea L. Optogenetic control of hypocretin (orexin) neurons and arousal circuits. Current Topics in Behavioral Neurosciences. 25: 367-78. PMID 25502546 DOI: 10.1007/7854_2014_364  0.417
2015 Herrera CG, Adamantidis A, Zhang F, Deisseroth K, de Lecea L. Optogenetic dissection of neural circuit function in behaving animals Neuromethods. 92: 143-160. DOI: 10.1007/978-1-4939-1963-5_7  0.629
2014 Mosqueiro T, de Lecea L, Huerta R. Control of sleep-to-wake transitions via fast aminoacid and slow neuropeptide transmission. New Journal of Physics. 16. PMID 25598695 DOI: 10.1088/1367-2630/16/11/115010  0.314
2014 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. The Journal of Experimental Medicine. 211: 2487-96. PMID 25422493 DOI: 10.1084/Jem.20141788  0.382
2014 Irmak SO, de Lecea L. Basal forebrain cholinergic modulation of sleep transitions. Sleep. 37: 1941-51. PMID 25325504 DOI: 10.5665/sleep.4246  0.431
2014 Adamantidis AR, Zhang F, de Lecea L, Deisseroth K. Optogenetics: opsins and optical interfaces in neuroscience. Cold Spring Harbor Protocols. 2014: 815-22. PMID 25086025 DOI: 10.1101/Pdb.Top083329  0.632
2014 Adamantidis AR, Zhang F, de Lecea L, Deisseroth K. Establishing a fiber-optic-based optical neural interface. Cold Spring Harbor Protocols. 2014: 839-44. PMID 25086020 DOI: 10.1101/Pdb.Prot083337  0.644
2014 Giardino WJ, de Lecea L. Hypocretin (orexin) neuromodulation of stress and reward pathways. Current Opinion in Neurobiology. 29: 103-8. PMID 25050887 DOI: 10.1016/j.conb.2014.07.006  0.729
2014 de Lecea L, Huerta R. Hypocretin (orexin) regulation of sleep-to-wake transitions. Frontiers in Pharmacology. 5: 16. PMID 24575043 DOI: 10.3389/fphar.2014.00016  0.389
2013 Rolls A, Makam M, Kroeger D, Colas D, de Lecea L, Heller HC. Sleep to forget: interference of fear memories during sleep. Molecular Psychiatry. 18: 1166-70. PMID 24081009 DOI: 10.1038/Mp.2013.121  0.789
2013 Carter ME, de Lecea L, Adamantidis A. Functional wiring of hypocretin and LC-NE neurons: implications for arousal. Frontiers in Behavioral Neuroscience. 7: 43. PMID 23730276 DOI: 10.3389/Fnbeh.2013.00043  0.771
2013 Touriño C, Eban-Rothschild A, de Lecea L. Optogenetics in psychiatric diseases. Current Opinion in Neurobiology. 23: 430-5. PMID 23642859 DOI: 10.1016/J.Conb.2013.03.007  0.784
2013 Kempadoo KA, Tourino C, Cho SL, Magnani F, Leinninger GM, Stuber GD, Zhang F, Myers MG, Deisseroth K, de Lecea L, Bonci A. Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7618-26. PMID 23637156 DOI: 10.1523/Jneurosci.2588-12.2013  0.506
2013 De Lecea L, Sutcliffe JG. Hypocretins (Orexins) Handbook of Biologically Active Peptides. 812-818. DOI: 10.1016/B978-0-12-385095-9.00108-1  0.562
2012 Cañellas F, de Lecea L. [Relationships between sleep and addiction]. Adicciones. 24: 287-90. PMID 23241715  0.373
2012 Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea L. Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proceedings of the National Academy of Sciences of the United States of America. 109: E2635-44. PMID 22955882 DOI: 10.1073/Pnas.1202526109  0.854
2012 de Lecea L. Hypocretins and the neurobiology of sleep-wake mechanisms. Progress in Brain Research. 198: 15-24. PMID 22813967 DOI: 10.1016/B978-0-444-59489-1.00003-3  0.403
2012 de Lecea L, Carter ME, Adamantidis A. Shining light on wakefulness and arousal. Biological Psychiatry. 71: 1046-52. PMID 22440618 DOI: 10.1016/J.Biopsych.2012.01.032  0.706
2011 Karnani MM, Apergis-Schoute J, Adamantidis A, Jensen LT, de Lecea L, Fugger L, Burdakov D. Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron. 72: 616-29. PMID 22099463 DOI: 10.1016/J.Neuron.2011.08.027  0.598
2011 Gutierrez R, Lobo MK, Zhang F, de Lecea L. Neural integration of reward, arousal, and feeding: recruitment of VTA, lateral hypothalamus, and ventral striatal neurons. Iubmb Life. 63: 824-30. PMID 21901814 DOI: 10.1002/Iub.539  0.338
2011 Adamantidis AR, Tsai HC, Boutrel B, Zhang F, Stuber GD, Budygin EA, Touriño C, Bonci A, Deisseroth K, de Lecea L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10829-35. PMID 21795535 DOI: 10.1523/Jneurosci.2246-11.2011  0.802
2011 Rolls A, Colas D, Adamantidis A, Carter M, Lanre-Amos T, Heller HC, de Lecea L. Optogenetic disruption of sleep continuity impairs memory consolidation. Proceedings of the National Academy of Sciences of the United States of America. 108: 13305-10. PMID 21788501 DOI: 10.1073/Pnas.1015633108  0.781
2011 Carter ME, de Lecea L. Optogenetic investigation of neural circuits in vivo. Trends in Molecular Medicine. 17: 197-206. PMID 21353638 DOI: 10.1016/J.Molmed.2010.12.005  0.574
2010 Rolls A, Schaich Borg J, de Lecea L. Sleep and metabolism: role of hypothalamic neuronal circuitry. Best Practice & Research. Clinical Endocrinology & Metabolism. 24: 817-28. PMID 21112028 DOI: 10.1016/j.beem.2010.08.002  0.693
2010 Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nature Neuroscience. 13: 1526-33. PMID 21037585 DOI: 10.1038/Nn.2682  0.795
2010 Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system. Proceedings of the National Academy of Sciences of the United States of America. 107: 19567-72. PMID 20974945 DOI: 10.1073/Pnas.1004100107  0.739
2010 Bonnavion P, de Lecea L. Hypocretins in the control of sleep and wakefulness. Current Neurology and Neuroscience Reports. 10: 174-9. PMID 20425032 DOI: 10.1007/S11910-010-0101-Y  0.81
2010 Pujadas L, Gruart A, Bosch C, Delgado L, Teixeira CM, Rossi D, de Lecea L, Martínez A, Delgado-García JM, Soriano E. Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4636-49. PMID 20357114 DOI: 10.1523/Jneurosci.5284-09.2010  0.44
2010 Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nature Protocols. 5: 439-56. PMID 20203662 DOI: 10.1038/Nprot.2009.226  0.652
2010 Adamantidis A, Carter MC, de Lecea L. Optogenetic deconstruction of sleep-wake circuitry in the brain. Frontiers in Molecular Neuroscience. 2: 31. PMID 20126433 DOI: 10.3389/neuro.02.031.2009  0.678
2010 Boutrel B, Cannella N, de Lecea L. The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Research. 1314: 103-11. PMID 19948148 DOI: 10.1016/J.Brainres.2009.11.054  0.706
2010 Adamantidis A, de Lecea L. Hypocretin/Orexin and MCH and Receptors Encyclopedia of Neuroscience. 51-56. DOI: 10.1016/B978-008045046-9.01443-1  0.524
2009 Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10939-49. PMID 19726652 DOI: 10.1523/Jneurosci.1205-09.2009  0.813
2009 Kroeger D, de Lecea L. The hypocretins and their role in narcolepsy. Cns & Neurological Disorders Drug Targets. 8: 271-80. PMID 19689309 DOI: 10.2174/187152709788921645  0.672
2009 Adamantidis A, de Lecea L. A role for Melanin-Concentrating Hormone in learning and memory. Peptides. 30: 2066-70. PMID 19576257 DOI: 10.1016/j.peptides.2009.06.024  0.545
2009 Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (New York, N.Y.). 324: 1080-4. PMID 19389999 DOI: 10.1126/Science.1168878  0.705
2009 Carter ME, Schaich Borg J, de Lecea L. The brain hypocretins and their receptors: mediators of allostatic arousal. Current Opinion in Pharmacology. 9: 39-45. PMID 19185540 DOI: 10.1016/J.Coph.2008.12.018  0.639
2009 Adamantidis A, de Lecea L. The hypocretins as sensors for metabolism and arousal. The Journal of Physiology. 587: 33-40. PMID 19047201 DOI: 10.1113/jphysiol.2008.164400  0.658
2008 Adamantidis A, de Lecea L. Sleep and metabolism: shared circuits, new connections. Trends in Endocrinology and Metabolism: Tem. 19: 362-70. PMID 18938086 DOI: 10.1016/j.tem.2008.08.007  0.669
2008 de Lecea L, Bourgin P. Neuropeptide interactions and REM sleep: a role for Urotensin II? Peptides. 29: 845-51. PMID 18406008 DOI: 10.1016/J.Peptides.2008.02.009  0.698
2008 Adamantidis A, de Lecea L. Physiological arousal: a role for hypothalamic systems. Cellular and Molecular Life Sciences : Cmls. 65: 1475-88. PMID 18351292 DOI: 10.1007/S00018-008-7521-8  0.666
2008 Boutrel B, de Lecea L. Addiction and arousal: the hypocretin connection. Physiology & Behavior. 93: 947-51. PMID 18262574 DOI: 10.1016/J.Physbeh.2007.11.022  0.703
2008 De Lecea L. Neuropeptides and sleep-wake regulation Neurochemistry of Sleep and Wakefulness. 387-401. DOI: 10.1017/CBO9780511541674.015  0.354
2007 Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature. 450: 420-4. PMID 17943086 DOI: 10.1038/Nature06310  0.772
2007 Bourgin P, Fabre V, Huitrón-Reséndiz S, Henriksen SJ, Prospero-Garcia O, Criado JR, de Lecea L. Cortistatin promotes and negatively correlates with slow-wave sleep. The European Journal of Neuroscience. 26: 729-38. PMID 17686045 DOI: 10.1111/J.1460-9568.2007.05696.X  0.823
2007 Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K. Circuit-breakers: optical technologies for probing neural signals and systems. Nature Reviews. Neuroscience. 8: 577-81. PMID 17643087 DOI: 10.1038/nrn2192  0.645
2006 Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Resendiz S, Henriksen S, Zorrilla EP, de Lecea L, Bartfai T. Transgenic mice with a reduced core body temperature have an increased life span. Science (New York, N.Y.). 314: 825-8. PMID 17082459 DOI: 10.1126/Science.1132191  0.764
2006 de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R. Addiction and arousal: alternative roles of hypothalamic peptides. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10372-5. PMID 17035520 DOI: 10.1523/Jneurosci.3118-06.2006  0.716
2006 Adamantidis A, Carter ME, de Lecea L. Optogenetic control of arousal neurons The Genetic Basis of Sleep and Sleep Disorders. 66-72. DOI: 10.1017/CBO9781139649469.009  0.731
2005 Winsky-Sommerer R, Boutrel B, de Lecea L. Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry. Molecular Neurobiology. 32: 285-94. PMID 16385142 DOI: 10.1385/Mn:32:3:285  0.808
2005 Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 19168-73. PMID 16357203 DOI: 10.1073/Pnas.0507480102  0.705
2005 de Lecea L, Sutcliffe JG. The hypocretins and sleep. The Febs Journal. 272: 5675-88. PMID 16279933 DOI: 10.1111/J.1742-4658.2005.04981.X  0.674
2005 Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C, Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A, de Lecea L. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning. Molecular and Cellular Neurosciences. 30: 465-75. PMID 16182561 DOI: 10.1016/J.Mcn.2005.08.010  0.797
2005 Ureña JM, La Torre A, Martínez A, Lowenstein E, Franco N, Winsky-Sommerer R, Fontana X, Casaroli-Marano R, Ibáñez-Sabio MA, Pascual M, Del Rio JA, de Lecea L, Soriano E. Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. The Journal of Comparative Neurology. 490: 119-32. PMID 16052498 DOI: 10.1002/Cne.20656  0.721
2005 Pañeda C, Winsky-Sommerer R, Boutrel B, de Lecea L. The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction. Drug News & Perspectives. 18: 250-5. PMID 16034481 DOI: 10.1358/Dnp.2005.18.4.908659  0.8
2005 Huitron-Resendiz S, Kristensen MP, Sánchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5465-74. PMID 15944374 DOI: 10.1523/Jneurosci.4501-04.2005  0.785
2005 Levine AS, Winsky-Sommerer R, Huitron-Resendiz S, Grace MK, de Lecea L. Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1727-32. PMID 15886360 DOI: 10.1152/Ajpregu.00638.2003  0.654
2005 Spier AD, Fabre V, de Lecea L. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Regulatory Peptides. 124: 179-86. PMID 15544857 DOI: 10.1016/J.Regpep.2004.07.015  0.592
2005 De Lecea L, Sutcliffe JG. The discovery of the hypocretins: New hypothalamic peptides Hypocretins: Integrators of Physiological Functions. 3-11. DOI: 10.1007/0-387-25446-3_1  0.463
2004 Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11439-48. PMID 15601950 DOI: 10.1523/Jneurosci.3459-04.2004  0.707
2004 Winsky-Sommerer R, Spier AD, Fabre V, de Lecea L, Criado JR. Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice. Brain Research. 1023: 157-62. PMID 15364032 DOI: 10.1016/J.Brainres.2004.04.082  0.755
2004 Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 43: 487-97. PMID 15312648 DOI: 10.1016/J.Neuron.2004.08.005  0.72
2004 Guillén-Gómez E, Calbet M, Casado J, de Lecea L, Soriano E, Pastor-Anglada M, Burgaya F. Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived rats. Journal of Neurochemistry. 90: 883-93. PMID 15287894 DOI: 10.1111/J.1471-4159.2004.02545.X  0.519
2004 Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 311: 265-73. PMID 15263066 DOI: 10.1124/Jpet.104.067504  0.602
2004 Sutcliffe JG, de Lecea L. Not asleep, not quite awake. Nature Medicine. 10: 673-4. PMID 15229508 DOI: 10.1038/Nm0704-673  0.464
2004 García-Frigola C, Burgaya F, Calbet M, López-Domènech G, de Lecea L, Soriano E. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. Brain Research. Molecular Brain Research. 122: 133-50. PMID 15010206 DOI: 10.1016/J.Molbrainres.2003.12.014  0.405
2003 Siggins GR, Martin G, Roberto M, Nie Z, Madamba S, De Lecea L. Glutamatergic transmission in opiate and alcohol dependence. Annals of the New York Academy of Sciences. 1003: 196-211. PMID 14684447 DOI: 10.1196/Annals.1300.012  0.536
2003 Winsky-Sommerer R, Boutrel B, De Lecea L. The role of the hypocretinergic system in the integration of networks that dictate the states of arousal. Drug News & Perspectives. 16: 504-12. PMID 14668948 DOI: 10.1358/Dnp.2003.16.8.829349  0.841
2002 de Lecea L, Sutcliffe JG, Fabre V. Hypocretins/orexins as integrators of physiological information: lessons from mutant animals. Neuropeptides. 36: 85-95. PMID 12359500 DOI: 10.1054/Npep.2002.0892  0.763
2002 Krucker T, Siggins GR, McNamara RK, Lindsley KA, Dao A, Allison DW, De Lecea L, Lovenberg TW, Sutcliffe JG, Gerendasy DD. Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5525-35. PMID 12097504 DOI: 10.1523/Jneurosci.22-13-05525.2002  0.651
2002 Sutcliffe JG, de Lecea L. The hypocretins: setting the arousal threshold. Nature Reviews. Neuroscience. 3: 339-49. PMID 11988773 DOI: 10.1038/Nrn808  0.661
2002 Martin G, Fabre V, Siggins GR, de Lecea L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens. Regulatory Peptides. 104: 111-7. PMID 11830285 DOI: 10.1016/S0167-0115(01)00354-8  0.71
2001 García-Frigola C, Burgaya F, de Lecea L, Soriano E. Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse. Mechanisms of Development. 106: 207-12. PMID 11472858 DOI: 10.1016/S0925-4773(01)00436-1  0.395
2001 Galas L, Vaudry H, Braun B, Van Den Pol AN, De Lecea L, Sutcliffe JG, Chartrel N. Immunohistochemical localization and biochemical characterization of hypocretin/orexin-related peptides in the central nervous system of the frog Rana ridibunda. The Journal of Comparative Neurology. 429: 242-52. PMID 11116217 DOI: 10.1002/1096-9861(20000108)429:2<242::Aid-Cne5>3.0.Co;2-Z  0.525
2000 García-Frigola C, Burgaya F, Calbet M, de Lecea L, Soriano E. Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures. Neuroreport. 11: 3181-5. PMID 11043545 DOI: 10.1097/00001756-200009280-00027  0.412
2000 Bourgin P, Huitrón-Résendiz S, Spier AD, Fabre V, Morte B, Criado JR, Sutcliffe JG, Henriksen SJ, de Lecea L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7760-5. PMID 11027239 DOI: 10.1523/Jneurosci.20-20-07760.2000  0.839
2000 Sutcliffe JG, de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. Journal of Neuroscience Research. 62: 161-8. PMID 11020209 DOI: 10.1002/1097-4547(20001015)62:2<161::Aid-Jnr1>3.0.Co;2-1  0.678
2000 Spier AD, de Lecea L. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Research. Brain Research Reviews. 33: 228-41. PMID 11011067 DOI: 10.1016/S0165-0173(00)00031-X  0.378
1999 de Lecea L, Sutcliffe JG. The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems. Cellular and Molecular Life Sciences : Cmls. 56: 473-80. PMID 11212299 DOI: 10.1007/s000180050446  0.573
1999 Calbet M, Guadaño-Ferraz A, Spier AD, Maj M, Sutcliffe JG, PrzewÅ‚ocki R, de Lecea L. Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate. Brain Research. Molecular Brain Research. 72: 55-64. PMID 10521599 DOI: 10.1016/S0169-328X(99)00220-X  0.601
1999 Sutcliffe JG, de Lecea L. Novel neurotransmitters for sleep and energy homeostasis. Results and Problems in Cell Differentiation. 26: 239-55. PMID 10453467 DOI: 10.1007/978-3-540-49421-8_11  0.62
1999 HÃ¥kansson M, de Lecea L, Sutcliffe JG, Yanagisawa M, Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. Journal of Neuroendocrinology. 11: 653-63. PMID 10447804 DOI: 10.1046/j.1365-2826.1999.00378.x  0.617
1999 Criado JR, Li H, Jiang X, Spina M, Huitrón-Reséndiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L. Structural and compositional determinants of cortistatin activity. Journal of Neuroscience Research. 56: 611-9. PMID 10374816 DOI: 10.1002/(Sici)1097-4547(19990615)56:6<611::Aid-Jnr7>3.0.Co;2-G  0.807
1999 Campbell KM, de Lecea L, Severynse DM, Caron MG, McGrath MJ, Sparber SB, Sun LY, Burton FH. OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5044-53. PMID 10366637 DOI: 10.1523/Jneurosci.19-12-05044.1999  0.795
1999 Vasilaki A, Lanneau C, Dournaud P, De Lecea L, Gardette R, Epelbaum J. Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of sst2 somatostatin receptor subtype. Neuroscience. 88: 359-64. PMID 10197759 DOI: 10.1016/S0306-4522(98)00413-8  0.348
1998 Broberger C, De Lecea L, Sutcliffe JG, Hökfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. The Journal of Comparative Neurology. 402: 460-74. PMID 9862321 DOI: 10.1002/(SICI)1096-9861(19981228)402:4<460::AID-CNE3>3.0.CO;2-S  0.537
1998 Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9996-10015. PMID 9822755 DOI: 10.1523/Jneurosci.18-23-09996.1998  0.617
1998 de Lecea L, Criado JR, Rivera S, Wen W, Soriano E, Henriksen SJ, Taylor SS, Gall CM, Sutcliffe JG. Endogenous protein kinase A inhibitor (PKIalpha) modulates synaptic activity. Journal of Neuroscience Research. 53: 269-78. PMID 9698155 DOI: 10.1002/(Sici)1097-4547(19980801)53:3<269::Aid-Jnr1>3.0.Co;2-8  0.773
1998 de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 322-7. PMID 9419374 DOI: 10.1073/pnas.95.1.322  0.673
1997 de Lecea L, del Rio JA, Criado JR, Alcántara S, Morales M, Danielson PE, Henriksen SJ, Soriano E, Sutcliffe JG. Cortistatin is expressed in a distinct subset of cortical interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5868-80. PMID 9221784 DOI: 10.1523/Jneurosci.17-15-05868.1997  0.814
1997 de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. Genomics. 42: 499-506. PMID 9205124 DOI: 10.1006/Geno.1997.4763  0.525
1997 de Lecea L, del Rio JA, Criado JR, Alcántara S, Morales M, Danielson PE, Henriksen SJ, Soriano E, Sutcliffe JG. Cortistatin Is Expressed in a Distinct Subset of Cortical Interneurons The Journal of Neuroscience. 17: 5868-5880. DOI: 10.1523/JNEUROSCI.17-15-05868.1997  0.706
1996 de Lecea L, Sutcliffe JG. Peptides, sleep and cortistatin. Molecular Psychiatry. 1: 349-51. PMID 9154223  0.592
1996 Morales M, Battenberg E, de Lecea L, Sanna PP, Bloom FE. Cellular and subcellular immunolocalization of the type 3 serotonin receptor in the rat central nervous system. Brain Research. Molecular Brain Research. 36: 251-60. PMID 8965645 DOI: 10.1016/0169-328X(96)88406-3  0.62
1996 Morales M, Battenberg E, de Lecea L, Bloom FE. The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus. Brain Research. 731: 199-202. PMID 8883870 DOI: 10.1016/0006-8993(96)00557-4  0.626
1996 Alcantara S, de Lecea L, Del Rio JA, Ferrer I, Soriano E. Transient colocalization of parvalbumin and calbindin D28k in the postnatal cerebral cortex: evidence for a phenotypic shift in developing nonpyramidal neurons. The European Journal of Neuroscience. 8: 1329-39. PMID 8758940 DOI: 10.1111/J.1460-9568.1996.Tb01595.X  0.489
1996 Gautvik KM, de Lecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG. Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proceedings of the National Academy of Sciences of the United States of America. 93: 8733-8. PMID 8710940 DOI: 10.1073/pnas.93.16.8733  0.604
1996 Rocamora N, Pascual M, Acsàdy L, de Lecea L, Freund TF, Soriano E. Expression of NGF and NT3 mRNAs in hippocampal interneurons innervated by the GABAergic septohippocampal pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3991-4004. PMID 8656293 DOI: 10.1523/Jneurosci.16-12-03991.1996  0.446
1996 de Lecea L, Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 381: 242-5. PMID 8622767 DOI: 10.1038/381242A0  0.838
1996 Iniguez MA, De Lecea L, Guadano-Ferraz A, Morte B, Gerendasy D, Sutcliffe JG, Bernal J. Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain. Endocrinology. 137: 1032-41. PMID 8603571 DOI: 10.1210/endo.137.3.8603571  0.539
1996 Rocamora N, Pascual M, Acsàdy L, de Lecea L, Freund TF, Soriano E. Expression of NGF and NT3 mRNAs in Hippocampal Interneurons Innervated by the GABAergic Septohippocampal Pathway The Journal of Neuroscience. 16: 3991-4004. DOI: 10.1523/JNEUROSCI.16-12-03991.1996  0.392
1995 de Lecea L, del Río JA, Soriano E. Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat. Brain Research. Molecular Brain Research. 32: 1-13. PMID 7494447 DOI: 10.1016/0169-328X(95)00056-X  0.414
1994 Usui H, Falk JD, Dopazo A, de Lecea L, Erlander MG, Sutcliffe JG. Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtraction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4915-26. PMID 8046460  0.492
1994 Danielson PE, Watson JB, Gerendasy DD, Erlander MG, Lovenberg TW, de Lecea L, Sutcliffe JG, Frankel WN. Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Genomics. 19: 454-61. PMID 7910582 DOI: 10.1006/Geno.1994.1094  0.495
1994 del Río JA, de Lecea L, Ferrer I, Soriano E. The development of parvalbumin-immunoreactivity in the neocortex of the mouse. Brain Research. Developmental Brain Research. 81: 247-59. PMID 7813046 DOI: 10.1016/0165-3806(94)90311-5  0.442
1994 de Lecea L, Soriano E, Criado JR, Steffensen SC, Henriksen SJ, Sutcliffe JG. Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity. Brain Research. Molecular Brain Research. 25: 286-96. PMID 7808228 DOI: 10.1016/0169-328X(94)90164-3  0.788
1994 Watson JB, Coulter PM, Margulies JE, de Lecea L, Danielson PE, Erlander MG, Sutcliffe JG. G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum. Journal of Neuroscience Research. 39: 108-16. PMID 7807587 DOI: 10.1002/Jnr.490390113  0.553
1993 Erlander MG, Lovenberg TW, Baron BM, de Lecea L, Sutcliffe JG. Molecular approach to hypothalamic rhythms: isolation of novel indoleamine receptor genes. Journal of Biological Rhythms. 8: S25-31. PMID 8274759  0.501
1992 Soriano E, Del Rio JA, Ferrer I, Auladell C, De Lecea L, Alcantara S. Late appearance of parvalbumin-immunoreactive neurons in the rodent cerebral cortex does not follow an 'inside-out' sequence. Neuroscience Letters. 142: 147-50. PMID 1454208 DOI: 10.1016/0304-3940(92)90360-J  0.504
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