Luis de Lecea - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Sleep, hypocretin, hypothalamus, addiction

157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Yamaguchi H, Hopf FW, Li SB, de Lecea L. In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness. Nature Communications. 9: 5211. PMID 30523254 DOI: 10.1038/s41467-018-07566-3  0.88
2018 Yamaguchi H, de Lecea L. In vivo cell type-specific CRISPR gene editing for sleep research. Journal of Neuroscience Methods. PMID 30439390 DOI: 10.1016/j.jneumeth.2018.10.016  0.88
2018 Tyree SM, Borniger JC, de Lecea L. Hypocretin as a Hub for Arousal and Motivation. Frontiers in Neurology. 9: 413. PMID 29928253 DOI: 10.3389/fneur.2018.00413  1
2017 Eban-Rothschild A, Appelbaum L, de Lecea L. Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29206811 DOI: 10.1038/npp.2017.294  1
2017 Tyree SM, de Lecea L. Optogenetic Investigation of Arousal Circuits. International Journal of Molecular Sciences. 18. PMID 28809797 DOI: 10.3390/ijms18081773  1
2017 Tyree SM, de Lecea L. Lateral Hypothalamic Control of the Ventral Tegmental Area: Reward Evaluation and the Driving of Motivated Behavior. Frontiers in Systems Neuroscience. 11: 50. PMID 28729827 DOI: 10.3389/fnsys.2017.00050  1
2017 Eban-Rothschild A, de Lecea L. Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states. F1000research. 6: 212. PMID 28357049 DOI: 10.12688/f1000research.9677.1  1
2016 Li SB, Jones JR, de Lecea L. Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders. Current Psychiatry Reports. 18: 7. PMID 26733323 DOI: 10.1007/s11920-015-0639-0  1
2015 Giardino WJ, de Lecea L. Resting easy with a sleep regulator. Elife. 4. PMID 26651823 DOI: 10.7554/eLife.12093  1
2015 Rolls A, Pang WW, Ibarra I, Colas D, Bonnavion P, Korin B, Heller HC, Weissman IL, de Lecea L. Sleep disruption impairs haematopoietic stem cell transplantation in mice. Nature Communications. 6: 8516. PMID 26465715 DOI: 10.1038/ncomms9516  1
2015 Zhang F, Tsai HC, Airan RD, Stuber GD, Adamantidis AR, de Lecea L, Bonci A, Deisseroth K. Optogenetics in Freely Moving Mammals: Dopamine and Reward. Cold Spring Harbor Protocols. 2015: pdb.top086330. PMID 26240415 DOI: 10.1101/pdb.top086330  0.72
2015 Pedraza-Arévalo S, Córdoba-Chacón J, Pozo-Salas AI, L-López F, de Lecea L, Gahete MD, Castaño JP, Luque RM. Not So Giants: Mice Lacking Both Somatostatin and Cortistatin Have High GH Levels but Show No Changes in Growth Rate or IGF-1 Levels. Endocrinology. 156: 1958-64. PMID 25830706 DOI: 10.1210/en.2015-1132  1
2015 Villa-Osaba A, Gahete MD, Córdoba-Chacón J, de Lecea L, Pozo-Salas AI, Delgado-Lista FJ, Álvarez-Benito M, López-Miranda J, Luque RM, Castaño JP. Obesity alters gene expression for GH/IGF-I axis in mouse mammary fat pads: differential role of cortistatin and somatostatin. Plos One. 10: e0120955. PMID 25806796 DOI: 10.1371/journal.pone.0120955  1
2015 Sorooshyari S, Huerta R, de Lecea L. A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition. Frontiers in Neurology. 6: 32. PMID 25767461 DOI: 10.3389/fneur.2015.00032  1
2015 Bonnavion P, Jackson AC, Carter ME, de Lecea L. Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses. Nature Communications. 6: 6266. PMID 25695914 DOI: 10.1038/ncomms7266  1
2015 de Lecea L. Optogenetic control of hypocretin (orexin) neurons and arousal circuits. Current Topics in Behavioral Neurosciences. 25: 367-78. PMID 25502546 DOI: 10.1007/7854_2014_364  1
2015 Chen Q, de Lecea L, Hu Z, Gao D. The hypocretin/orexin system: an increasingly important role in neuropsychiatry. Medicinal Research Reviews. 35: 152-97. PMID 25044006 DOI: 10.1002/med.21326  1
2015 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Joy Snider B, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Correction to Potential role of orexin and sleep modulation in the pathogenesis of alzheimer's disease [The Journal of Experimental Medicine, 211, 13, (2014), 2487-2496] Journal of Experimental Medicine. 212: 121. DOI: 10.1084/jem.2014178812122014c  1
2015 De Lecea L. The hypocretin story Orexin and Sleep: Molecular, Functional and Clinical Aspects. 27-35. DOI: 10.1007/978-3-319-23078-8_2  1
2015 Herrera CG, Adamantidis A, Zhang F, Deisseroth K, de Lecea L. Optogenetic dissection of neural circuit function in behaving animals Neuromethods. 92: 143-160. DOI: 10.1007/978-1-4939-1963-5_7  1
2014 Mosqueiro T, de Lecea L, Huerta R. Control of sleep-to-wake transitions via fast aminoacid and slow neuropeptide transmission. New Journal of Physics. 16. PMID 25598695 DOI: 10.1088/1367-2630/16/11/115010  0.56
2014 Roh JH, Jiang H, Finn MB, Stewart FR, Mahan TE, Cirrito JR, Heda A, Snider BJ, Li M, Yanagisawa M, de Lecea L, Holtzman DM. Potential role of orexin and sleep modulation in the pathogenesis of Alzheimer's disease. The Journal of Experimental Medicine. 211: 2487-96. PMID 25422493 DOI: 10.1084/jem.20141788  1
2014 Irmak SO, de Lecea L. Basal forebrain cholinergic modulation of sleep transitions. Sleep. 37: 1941-51. PMID 25325504 DOI: 10.5665/sleep.4246  1
2014 Whittle AJ, Walsh J, de Lecea L. Light and chemical control of neuronal circuits: possible applications in neurotherapy. Expert Review of Neurotherapeutics. 14: 1007-17. PMID 25115180 DOI: 10.1586/14737175.2014.948850  1
2014 Adamantidis AR, Zhang F, de Lecea L, Deisseroth K. Optogenetics: opsins and optical interfaces in neuroscience. Cold Spring Harbor Protocols. 2014: 815-22. PMID 25086025 DOI: 10.1101/pdb.top083329  1
2014 Adamantidis AR, Zhang F, de Lecea L, Deisseroth K. Establishing a fiber-optic-based optical neural interface. Cold Spring Harbor Protocols. 2014: 839-44. PMID 25086020 DOI: 10.1101/pdb.prot083337  1
2014 Giardino WJ, de Lecea L. Hypocretin (orexin) neuromodulation of stress and reward pathways. Current Opinion in Neurobiology. 29: 103-8. PMID 25050887 DOI: 10.1016/j.conb.2014.07.006  1
2014 de Lecea L, Huerta R. Hypocretin (orexin) regulation of sleep-to-wake transitions. Frontiers in Pharmacology. 5: 16. PMID 24575043 DOI: 10.3389/fphar.2014.00016  1
2014 Morell M, Camprubí-Robles M, Culler MD, de Lecea L, Delgado M. Cortistatin attenuates inflammatory pain via spinal and peripheral actions. Neurobiology of Disease. 63: 141-54. PMID 24333694 DOI: 10.1016/j.nbd.2013.11.022  1
2014 Li J, Hu Z, de Lecea L. The hypocretins/orexins: integrators of multiple physiological functions. British Journal of Pharmacology. 171: 332-50. PMID 24102345 DOI: 10.1111/bph.12415  1
2013 Sears RM, Fink AE, Wigestrand MB, Farb CR, de Lecea L, Ledoux JE. Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proceedings of the National Academy of Sciences of the United States of America. 110: 20260-5. PMID 24277819 DOI: 10.1073/pnas.1320325110  1
2013 Rolls A, Makam M, Kroeger D, Colas D, de Lecea L, Heller HC. Sleep to forget: interference of fear memories during sleep. Molecular Psychiatry. 18: 1166-70. PMID 24081009 DOI: 10.1038/mp.2013.121  1
2013 Souza-Moreira L, Morell M, Delgado-Maroto V, Pedreño M, Martinez-Escudero L, Caro M, O'Valle F, Luque R, Gallo M, de Lecea L, Castaño JP, Gonzalez-Rey E. Paradoxical effect of cortistatin treatment and its deficiency on experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 191: 2144-54. PMID 23918980 DOI: 10.4049/jimmunol.1300384  1
2013 Carter ME, de Lecea L, Adamantidis A. Functional wiring of hypocretin and LC-NE neurons: implications for arousal. Frontiers in Behavioral Neuroscience. 7: 43. PMID 23730276 DOI: 10.3389/fnbeh.2013.00043  1
2013 Touriño C, Eban-Rothschild A, de Lecea L. Optogenetics in psychiatric diseases. Current Opinion in Neurobiology. 23: 430-5. PMID 23642859 DOI: 10.1016/j.conb.2013.03.007  1
2013 Kempadoo KA, Tourino C, Cho SL, Magnani F, Leinninger GM, Stuber GD, Zhang F, Myers MG, Deisseroth K, de Lecea L, Bonci A. Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7618-26. PMID 23637156 DOI: 10.1523/JNEUROSCI.2588-12.2013  1
2013 Duran-Prado M, Morell M, Delgado-Maroto V, Castaño JP, Aneiros-Fernandez J, de Lecea L, Culler MD, Hernandez-Cortes P, O'Valle F, Delgado M. Cortistatin inhibits migration and proliferation of human vascular smooth muscle cells and decreases neointimal formation on carotid artery ligation. Circulation Research. 112: 1444-55. PMID 23595952 DOI: 10.1161/CIRCRESAHA.112.300695  1
2013 Morell M, Souza-Moreira L, Caro M, O'Valle F, Forte-Lago I, de Lecea L, Gonzalez-Rey E, Delgado M. Analgesic effect of the neuropeptide cortistatin in murine models of arthritic inflammatory pain. Arthritis and Rheumatism. 65: 1390-401. PMID 23371349 DOI: 10.1002/art.37877  1
2013 Rao Y, Mineur YS, Gan G, Wang AH, Liu ZW, Wu X, Suyama S, de Lecea L, Horvath TL, Picciotto MR, Gao XB. Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice. The Journal of Physiology. 591: 1951-66. PMID 23318871 DOI: 10.1113/jphysiol.2012.246983  1
2013 De Lecea L, Sutcliffe JG. Hypocretins (Orexins) Handbook of Biologically Active Peptides. 812-818. DOI: 10.1016/B978-0-12-385095-9.00108-1  1
2012 Cañellas F, de Lecea L. [Relationships between sleep and addiction]. Adicciones. 24: 287-90. PMID 23241715  1
2012 Carter ME, Brill J, Bonnavion P, Huguenard JR, Huerta R, de Lecea L. Mechanism for Hypocretin-mediated sleep-to-wake transitions. Proceedings of the National Academy of Sciences of the United States of America. 109: E2635-44. PMID 22955882 DOI: 10.1073/pnas.1202526109  1
2012 de Lecea L. Hypocretins and the neurobiology of sleep-wake mechanisms. Progress in Brain Research. 198: 15-24. PMID 22813967 DOI: 10.1016/B978-0-444-59489-1.00003-3  1
2012 de Lecea L, Carter ME, Adamantidis A. Shining light on wakefulness and arousal. Biological Psychiatry. 71: 1046-52. PMID 22440618 DOI: 10.1016/j.biopsych.2012.01.032  1
2011 Karnani MM, Apergis-Schoute J, Adamantidis A, Jensen LT, de Lecea L, Fugger L, Burdakov D. Activation of central orexin/hypocretin neurons by dietary amino acids. Neuron. 72: 616-29. PMID 22099463 DOI: 10.1016/j.neuron.2011.08.027  1
2011 Córdoba-Chacón J, Gahete MD, Pozo-Salas AI, Martínez-Fuentes AJ, de Lecea L, Gracia-Navarro F, Kineman RD, Castaño JP, Luque RM. Cortistatin is not a somatostatin analogue but stimulates prolactin release and inhibits GH and ACTH in a gender-dependent fashion: potential role of ghrelin. Endocrinology. 152: 4800-12. PMID 21971153 DOI: 10.1210/en.2011-1542  1
2011 Gutierrez R, Lobo MK, Zhang F, de Lecea L. Neural integration of reward, arousal, and feeding: recruitment of VTA, lateral hypothalamus, and ventral striatal neurons. Iubmb Life. 63: 824-30. PMID 21901814 DOI: 10.1002/iub.539  1
2011 Sánchez-de-la-Torre M, Barceló A, Piérola J, Esquinas C, de la Peña M, Durán-Cantolla J, Capote F, Masa JF, Marin JM, Vilá M, Cao G, Martinez M, de Lecea L, Gozal D, Montserrat JM, et al. Plasma levels of neuropeptides and metabolic hormones, and sleepiness in obstructive sleep apnea. Respiratory Medicine. 105: 1954-60. PMID 21889324 DOI: 10.1016/j.rmed.2011.08.014  1
2011 Adamantidis AR, Tsai HC, Boutrel B, Zhang F, Stuber GD, Budygin EA, Touriño C, Bonci A, Deisseroth K, de Lecea L. Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10829-35. PMID 21795535 DOI: 10.1523/JNEUROSCI.2246-11.2011  1
2011 Rolls A, Colas D, Adamantidis A, Carter M, Lanre-Amos T, Heller HC, de Lecea L. Optogenetic disruption of sleep continuity impairs memory consolidation. Proceedings of the National Academy of Sciences of the United States of America. 108: 13305-10. PMID 21788501 DOI: 10.1073/pnas.1015633108  1
2011 Carter ME, de Lecea L. Optogenetic investigation of neural circuits in vivo. Trends in Molecular Medicine. 17: 197-206. PMID 21353638 DOI: 10.1016/j.molmed.2010.12.005  1
2011 Cao J, de Lecea L, Ikemoto S. Intraventricular administration of neuropeptide S has reward-like effects. European Journal of Pharmacology. 658: 16-21. PMID 21349268 DOI: 10.1016/j.ejphar.2011.02.009  1
2011 Sánchez-de-la-Torre M, Pierola J, Vidal C, Barceló A, de la Peña M, Hussain Z, Capote F, Durán J, Agustí AG, de Lecea L, Torres G, Esquinas C, Martinez M, Barbé F. Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea. Sleep & Breathing = Schlaf & Atmung. 15: 403-8. PMID 20405330 DOI: 10.1007/s11325-010-0348-1  1
2010 Rolls A, Schaich Borg J, de Lecea L. Sleep and metabolism: role of hypothalamic neuronal circuitry. Best Practice & Research. Clinical Endocrinology & Metabolism. 24: 817-28. PMID 21112028 DOI: 10.1016/j.beem.2010.08.002  1
2010 Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L. Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nature Neuroscience. 13: 1526-33. PMID 21037585 DOI: 10.1038/nn.2682  1
2010 Kallupi M, Cannella N, Economidou D, Ubaldi M, Ruggeri B, Weiss F, Massi M, Marugan J, Heilig M, Bonnavion P, de Lecea L, Ciccocioppo R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system. Proceedings of the National Academy of Sciences of the United States of America. 107: 19567-72. PMID 20974945 DOI: 10.1073/pnas.1004100107  1
2010 Bonnavion P, de Lecea L. Hypocretins in the control of sleep and wakefulness. Current Neurology and Neuroscience Reports. 10: 174-9. PMID 20425032 DOI: 10.1007/s11910-010-0101-y  1
2010 Pujadas L, Gruart A, Bosch C, Delgado L, Teixeira CM, Rossi D, de Lecea L, Martínez A, Delgado-García JM, Soriano E. Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4636-49. PMID 20357114 DOI: 10.1523/JNEUROSCI.5284-09.2010  1
2010 Zhang F, Gradinaru V, Adamantidis AR, Durand R, Airan RD, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nature Protocols. 5: 439-56. PMID 20203662 DOI: 10.1038/nprot.2009.226  1
2010 Plaza-Zabala A, Martín-García E, de Lecea L, Maldonado R, Berrendero F. Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2300-10. PMID 20147556 DOI: 10.1523/JNEUROSCI.5724-09.2010  1
2010 Adamantidis A, Carter MC, de Lecea L. Optogenetic deconstruction of sleep-wake circuitry in the brain. Frontiers in Molecular Neuroscience. 2: 31. PMID 20126433 DOI: 10.3389/neuro.02.031.2009  1
2010 Boutrel B, Cannella N, de Lecea L. The role of hypocretin in driving arousal and goal-oriented behaviors. Brain Research. 1314: 103-11. PMID 19948148 DOI: 10.1016/j.brainres.2009.11.054  1
2010 de Lecea L. A decade of hypocretins: past, present and future of the neurobiology of arousal. Acta Physiologica (Oxford, England). 198: 203-8. PMID 19473132 DOI: 10.1111/j.1748-1716.2009.02004.x  1
2010 Adamantidis A, de Lecea L. Hypocretin/Orexin and MCH and Receptors Encyclopedia of Neuroscience. 51-56. DOI: 10.1016/B978-008045046-9.01443-1  1
2009 Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L. Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10939-49. PMID 19726652 DOI: 10.1523/JNEUROSCI.1205-09.2009  1
2009 Kroeger D, de Lecea L. The hypocretins and their role in narcolepsy. Cns & Neurological Disorders Drug Targets. 8: 271-80. PMID 19689309 DOI: 10.2174/187152709788921645  1
2009 Adamantidis A, de Lecea L. A role for Melanin-Concentrating Hormone in learning and memory. Peptides. 30: 2066-70. PMID 19576257 DOI: 10.1016/j.peptides.2009.06.024  1
2009 Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (New York, N.Y.). 324: 1080-4. PMID 19389999 DOI: 10.1126/science.1168878  1
2009 Pañeda C, Huitron-Resendiz S, Frago LM, Chowen JA, Picetti R, de Lecea L, Roberts AJ. Neuropeptide S reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4155-61. PMID 19339610 DOI: 10.1523/JNEUROSCI.5256-08.2009  1
2009 Carter ME, Schaich Borg J, de Lecea L. The brain hypocretins and their receptors: mediators of allostatic arousal. Current Opinion in Pharmacology. 9: 39-45. PMID 19185540 DOI: 10.1016/j.coph.2008.12.018  1
2009 Adamantidis A, de Lecea L. The hypocretins as sensors for metabolism and arousal. The Journal of Physiology. 587: 33-40. PMID 19047201 DOI: 10.1113/jphysiol.2008.164400  1
2009 Carter M, De Lecea L. Hyperarousal and post-traumatic stress disorder: A role for the hypocretin system Post-Traumatic Stress Disorder: Basic Science and Clinical Practice. 201-211. DOI: 10.1007/978-1-60327-329-9_9  1
2008 Adamantidis A, de Lecea L. Sleep and metabolism: shared circuits, new connections. Trends in Endocrinology and Metabolism: Tem. 19: 362-70. PMID 18938086 DOI: 10.1016/j.tem.2008.08.007  1
2008 Castaño JP, Ghigo E, Kineman RD, de Lecea L, Malagón MM, Vaudry H. Somatostatin, cortistatin and their receptors in health and disease. Foreword. Molecular and Cellular Endocrinology. 286: 1-2. PMID 18456395 DOI: 10.1016/j.mce.2008.03.010  1
2008 Rubio A, Pérez M, de Lecea L, Avila J. Effect of cortistatin on tau phosphorylation at Ser262 site. Journal of Neuroscience Research. 86: 2462-75. PMID 18438934 DOI: 10.1002/jnr.21689  1
2008 de Lecea L, Bourgin P. Neuropeptide interactions and REM sleep: a role for Urotensin II? Peptides. 29: 845-51. PMID 18406008 DOI: 10.1016/j.peptides.2008.02.009  1
2008 Qiu C, Zeyda T, Johnson B, Hochgeschwender U, de Lecea L, Tallent MK. Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3567-76. PMID 18385315 DOI: 10.1523/JNEUROSCI.4679-07.2008  1
2008 de Lecea L. Cortistatin--functions in the central nervous system. Molecular and Cellular Endocrinology. 286: 88-95. PMID 18374474 DOI: 10.1016/j.mce.2007.12.014  1
2008 Adamantidis A, de Lecea L. Physiological arousal: a role for hypothalamic systems. Cellular and Molecular Life Sciences : Cmls. 65: 1475-88. PMID 18351292 DOI: 10.1007/s00018-008-7521-8  1
2008 Boutrel B, de Lecea L. Addiction and arousal: the hypocretin connection. Physiology & Behavior. 93: 947-51. PMID 18262574 DOI: 10.1016/j.physbeh.2007.11.022  1
2008 De Lecea L. Neuropeptides and sleep-wake regulation Neurochemistry of Sleep and Wakefulness. 387-401. DOI: 10.1017/CBO9780511541674.015  1
2007 Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature. 450: 420-4. PMID 17943086 DOI: 10.1038/nature06310  1
2007 Bourgin P, Fabre V, Huitrón-Reséndiz S, Henriksen SJ, Prospero-Garcia O, Criado JR, de Lecea L. Cortistatin promotes and negatively correlates with slow-wave sleep. The European Journal of Neuroscience. 26: 729-38. PMID 17686045 DOI: 10.1111/j.1460-9568.2007.05696.x  1
2007 Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K. Circuit-breakers: optical technologies for probing neural signals and systems. Nature Reviews. Neuroscience. 8: 577-81. PMID 17643087 DOI: 10.1038/nrn2192  1
2007 Rubio A, Avila J, de Lecea L. Cortistatin as a therapeutic target in inflammation. Expert Opinion On Therapeutic Targets. 11: 1-9. PMID 17150030 DOI: 10.1517/14728222.11.1.1  1
2006 Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Resendiz S, Henriksen S, Zorrilla EP, de Lecea L, Bartfai T. Transgenic mice with a reduced core body temperature have an increased life span. Science (New York, N.Y.). 314: 825-8. PMID 17082459 DOI: 10.1126/science.1132191  1
2006 de Lecea L, Jones BE, Boutrel B, Borgland SL, Nishino S, Bubser M, DiLeone R. Addiction and arousal: alternative roles of hypothalamic peptides. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10372-5. PMID 17035520 DOI: 10.1523/JNEUROSCI.3118-06.2006  1
2006 de Lecea L, Castaño JP. Cortistatin: not just another somatostatin analog. Nature Clinical Practice. Endocrinology & Metabolism. 2: 356-7. PMID 16932314 DOI: 10.1038/ncpendmet0219  1
2006 Adamantidis A, Carter ME, de Lecea L. Optogenetic control of arousal neurons The Genetic Basis of Sleep and Sleep Disorders. 66-72. DOI: 10.1017/CBO9781139649469.009  1
2005 de Lecea L. Cortistatin: a natural somatostatin analog. Journal of Endocrinological Investigation. 28: 10-4. PMID 16625839  1
2005 Winsky-Sommerer R, Boutrel B, de Lecea L. Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry. Molecular Neurobiology. 32: 285-94. PMID 16385142 DOI: 10.1385/MN:32:3:285  1
2005 Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 19168-73. PMID 16357203 DOI: 10.1073/pnas.0507480102  1
2005 de Lecea L, Sutcliffe JG. The hypocretins and sleep. The Febs Journal. 272: 5675-88. PMID 16279933 DOI: 10.1111/j.1742-4658.2005.04981.x  1
2005 Tallent MK, Fabre V, Qiu C, Calbet M, Lamp T, Baratta MV, Suzuki C, Levy CL, Siggins GR, Henriksen SJ, Criado JR, Roberts A, de Lecea L. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning. Molecular and Cellular Neurosciences. 30: 465-75. PMID 16182561 DOI: 10.1016/j.mcn.2005.08.010  1
2005 Ureña JM, La Torre A, Martínez A, Lowenstein E, Franco N, Winsky-Sommerer R, Fontana X, Casaroli-Marano R, Ibáñez-Sabio MA, Pascual M, Del Rio JA, de Lecea L, Soriano E. Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. The Journal of Comparative Neurology. 490: 119-32. PMID 16052498 DOI: 10.1002/cne.20656  1
2005 Pañeda C, Winsky-Sommerer R, Boutrel B, de Lecea L. The corticotropin-releasing factor-hypocretin connection: implications in stress response and addiction. Drug News & Perspectives. 18: 250-5. PMID 16034481 DOI: 10.1358/dnp.2005.18.4.908659  1
2005 Huitron-Resendiz S, Kristensen MP, Sánchez-Alavez M, Clark SD, Grupke SL, Tyler C, Suzuki C, Nothacker HP, Civelli O, Criado JR, Henriksen SJ, Leonard CS, de Lecea L. Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5465-74. PMID 15944374 DOI: 10.1523/JNEUROSCI.4501-04.2005  1
2005 Levine AS, Winsky-Sommerer R, Huitron-Resendiz S, Grace MK, de Lecea L. Injection of neuropeptide W into paraventricular nucleus of hypothalamus increases food intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1727-32. PMID 15886360 DOI: 10.1152/ajpregu.00638.2003  1
2005 Spier AD, Fabre V, de Lecea L. Cortistatin radioligand binding in wild-type and somatostatin receptor-deficient mouse brain. Regulatory Peptides. 124: 179-86. PMID 15544857 DOI: 10.1016/j.regpep.2004.07.015  1
2005 De Lecea L, Sutcliffe JG. The discovery of the hypocretins: New hypothalamic peptides Hypocretins: Integrators of Physiological Functions. 3-11. DOI: 10.1007/0-387-25446-3_1  1
2005 Dement WC. Foreword Hypocretins: Integrators of Physiological Functions. v. DOI: 10.1007/0-387-25446-3  1
2004 Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11439-48. PMID 15601950 DOI: 10.1523/JNEUROSCI.3459-04.2004  1
2004 Winsky-Sommerer R, Spier AD, Fabre V, de Lecea L, Criado JR. Overexpression of the human beta-amyloid precursor protein downregulates cortistatin mRNA in PDAPP mice. Brain Research. 1023: 157-62. PMID 15364032 DOI: 10.1016/j.brainres.2004.04.082  1
2004 Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O. Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 43: 487-97. PMID 15312648 DOI: 10.1016/j.neuron.2004.08.005  1
2004 Guillén-Gómez E, Calbet M, Casado J, de Lecea L, Soriano E, Pastor-Anglada M, Burgaya F. Distribution of CNT2 and ENT1 transcripts in rat brain: selective decrease of CNT2 mRNA in the cerebral cortex of sleep-deprived rats. Journal of Neurochemistry. 90: 883-93. PMID 15287894 DOI: 10.1111/j.1471-4159.2004.02545.x  1
2004 Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 311: 265-73. PMID 15263066 DOI: 10.1124/jpet.104.067504  1
2004 Sutcliffe JG, de Lecea L. Not asleep, not quite awake. Nature Medicine. 10: 673-4. PMID 15229508 DOI: 10.1038/nm0704-673  1
2004 García-Frigola C, Burgaya F, Calbet M, López-Domènech G, de Lecea L, Soriano E. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. Brain Research. Molecular Brain Research. 122: 133-50. PMID 15010206 DOI: 10.1016/j.molbrainres.2003.12.014  1
2003 Siggins GR, Martin G, Roberto M, Nie Z, Madamba S, De Lecea L. Glutamatergic transmission in opiate and alcohol dependence. Annals of the New York Academy of Sciences. 1003: 196-211. PMID 14684447 DOI: 10.1196/annals.1300.012  1
2003 Winsky-Sommerer R, Boutrel B, De Lecea L. The role of the hypocretinergic system in the integration of networks that dictate the states of arousal. Drug News & Perspectives. 16: 504-12. PMID 14668948 DOI: 10.1358/dnp.2003.16.8.829349  1
2002 de Lecea L, Sutcliffe JG, Fabre V. Hypocretins/orexins as integrators of physiological information: lessons from mutant animals. Neuropeptides. 36: 85-95. PMID 12359500 DOI: 10.1054/npep.2002.0892  1
2002 Krucker T, Siggins GR, McNamara RK, Lindsley KA, Dao A, Allison DW, De Lecea L, Lovenberg TW, Sutcliffe JG, Gerendasy DD. Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5525-35. PMID 12097504  1
2002 Sutcliffe JG, de Lecea L. The hypocretins: setting the arousal threshold. Nature Reviews. Neuroscience. 3: 339-49. PMID 11988773 DOI: 10.1038/nrn808  1
2002 Martin G, Fabre V, Siggins GR, de Lecea L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens. Regulatory Peptides. 104: 111-7. PMID 11830285 DOI: 10.1016/S0167-0115(01)00354-8  1
2001 García-Frigola C, Burgaya F, de Lecea L, Soriano E. Pattern of expression of the tetraspanin Tspan-5 during brain development in the mouse. Mechanisms of Development. 106: 207-12. PMID 11472858 DOI: 10.1016/S0925-4773(01)00436-1  1
2001 Kilduff TS, de Lecea L. Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems. The Journal of Comparative Neurology. 435: 1-5. PMID 11370007 DOI: 10.1002/cne.1189  1
2001 Galas L, Vaudry H, Braun B, Van Den Pol AN, De Lecea L, Sutcliffe JG, Chartrel N. Immunohistochemical localization and biochemical characterization of hypocretin/orexin-related peptides in the central nervous system of the frog Rana ridibunda. The Journal of Comparative Neurology. 429: 242-52. PMID 11116217 DOI: 10.1002/1096-9861(20000108)429:2<242::AID-CNE5>3.0.CO;2-Z  1
2000 García-Frigola C, Burgaya F, Calbet M, de Lecea L, Soriano E. Mouse Tspan-5, a member of the tetraspanin superfamily, is highly expressed in brain cortical structures. Neuroreport. 11: 3181-5. PMID 11043545  1
2000 Bourgin P, Huitrón-Résendiz S, Spier AD, Fabre V, Morte B, Criado JR, Sutcliffe JG, Henriksen SJ, de Lecea L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7760-5. PMID 11027239  1
2000 Sutcliffe JG, de Lecea L. The hypocretins: excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding. Journal of Neuroscience Research. 62: 161-8. PMID 11020209 DOI: 10.1002/1097-4547(20001015)62:2<161::AID-JNR1>3.0.CO;2-1  1
2000 Spier AD, de Lecea L. Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Research. Brain Research Reviews. 33: 228-41. PMID 11011067 DOI: 10.1016/S0165-0173(00)00031-X  1
2000 Løseth OP, de Lecea L, Calbet M, Danielson PE, Gautvik V, Høvring PI, Walaas SI, Gautvik KM. Developmental regulation of two isoforms of Ca(2+)/calmodulin-dependent protein kinase I beta in rat brain. Brain Research. 869: 137-45. PMID 10865068 DOI: 10.1016/S0006-8993(00)02359-3  1
1999 de Lecea L, Sutcliffe JG. The hypocretins/orexins: novel hypothalamic neuropeptides involved in different physiological systems. Cellular and Molecular Life Sciences : Cmls. 56: 473-80. PMID 11212299 DOI: 10.1007/s000180050446  1
1999 Calbet M, Guadaño-Ferraz A, Spier AD, Maj M, Sutcliffe JG, PrzewÅ‚ocki R, de Lecea L. Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate. Brain Research. Molecular Brain Research. 72: 55-64. PMID 10521599 DOI: 10.1016/S0169-328X(99)00220-X  1
1999 Sutcliffe JG, de Lecea L. Novel neurotransmitters for sleep and energy homeostasis. Results and Problems in Cell Differentiation. 26: 239-55. PMID 10453467  1
1999 HÃ¥kansson M, de Lecea L, Sutcliffe JG, Yanagisawa M, Meister B. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus. Journal of Neuroendocrinology. 11: 653-63. PMID 10447804 DOI: 10.1046/j.1365-2826.1999.00378.x  1
1999 Criado JR, Li H, Jiang X, Spina M, Huitrón-Reséndiz S, Liapakis G, Calbet M, Siehler S, Henriksen SJ, Koob G, Hoyer D, Sutcliffe JG, Goodman M, de Lecea L. Structural and compositional determinants of cortistatin activity. Journal of Neuroscience Research. 56: 611-9. PMID 10374816 DOI: 10.1002/(SICI)1097-4547(19990615)56:6<611::AID-JNR7>3.0.CO;2-G  1
1999 Campbell KM, de Lecea L, Severynse DM, Caron MG, McGrath MJ, Sparber SB, Sun LY, Burton FH. OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5044-53. PMID 10366637  1
1999 Vasilaki A, Lanneau C, Dournaud P, De Lecea L, Gardette R, Epelbaum J. Cortistatin affects glutamate sensitivity in mouse hypothalamic neurons through activation of sst2 somatostatin receptor subtype. Neuroscience. 88: 359-64. PMID 10197759 DOI: 10.1016/S0306-4522(98)00413-8  1
1998 Broberger C, De Lecea L, Sutcliffe JG, Hökfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. The Journal of Comparative Neurology. 402: 460-74. PMID 9862321 DOI: 10.1002/(SICI)1096-9861(19981228)402:4<460::AID-CNE3>3.0.CO;2-S  1
1998 Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS. Neurons containing hypocretin (orexin) project to multiple neuronal systems. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 9996-10015. PMID 9822755  1
1998 Alcántara S, Ruiz M, D'Arcangelo G, Ezan F, de Lecea L, Curran T, Sotelo C, Soriano E. Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7779-99. PMID 9742148  1
1998 de Lecea L, Criado JR, Rivera S, Wen W, Soriano E, Henriksen SJ, Taylor SS, Gall CM, Sutcliffe JG. Endogenous protein kinase A inhibitor (PKIalpha) modulates synaptic activity. Journal of Neuroscience Research. 53: 269-78. PMID 9698155 DOI: 10.1002/(SICI)1097-4547(19980801)53:3<269::AID-JNR1>3.0.CO;2-8  1
1998 de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 322-7. PMID 9419374 DOI: 10.1073/pnas.95.1.322  1
1997 de Lecea L, del Rio JA, Criado JR, Alcántara S, Morales M, Danielson PE, Henriksen SJ, Soriano E, Sutcliffe JG. Cortistatin is expressed in a distinct subset of cortical interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 5868-80. PMID 9221784  1
1997 de Lecea L, Ruiz-Lozano P, Danielson PE, Peelle-Kirley J, Foye PE, Frankel WN, Sutcliffe JG. Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. Genomics. 42: 499-506. PMID 9205124 DOI: 10.1006/geno.1997.4763  1
1996 de Lecea L, Sutcliffe JG. Peptides, sleep and cortistatin. Molecular Psychiatry. 1: 349-51. PMID 9154223  1
1996 Morales M, Battenberg E, de Lecea L, Sanna PP, Bloom FE. Cellular and subcellular immunolocalization of the type 3 serotonin receptor in the rat central nervous system. Brain Research. Molecular Brain Research. 36: 251-60. PMID 8965645 DOI: 10.1016/0169-328X(96)88406-3  1
1996 Morales M, Battenberg E, de Lecea L, Bloom FE. The type 3 serotonin receptor is expressed in a subpopulation of GABAergic neurons in the rat neocortex and hippocampus. Brain Research. 731: 199-202. PMID 8883870 DOI: 10.1016/S0006-8993(96)00557-4  1
1996 Alcantara S, de Lecea L, Del Rio JA, Ferrer I, Soriano E. Transient colocalization of parvalbumin and calbindin D28k in the postnatal cerebral cortex: evidence for a phenotypic shift in developing nonpyramidal neurons. The European Journal of Neuroscience. 8: 1329-39. PMID 8758940 DOI: 10.1111/j.1460-9568.1996.tb01595.x  1
1996 Gautvik KM, de Lecea L, Gautvik VT, Danielson PE, Tranque P, Dopazo A, Bloom FE, Sutcliffe JG. Overview of the most prevalent hypothalamus-specific mRNAs, as identified by directional tag PCR subtraction. Proceedings of the National Academy of Sciences of the United States of America. 93: 8733-8. PMID 8710940 DOI: 10.1073/pnas.93.16.8733  1
1996 Rocamora N, Pascual M, Acsàdy L, de Lecea L, Freund TF, Soriano E. Expression of NGF and NT3 mRNAs in hippocampal interneurons innervated by the GABAergic septohippocampal pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3991-4004. PMID 8656293  1
1996 de Lecea L, Criado JR, Prospero-Garcia O, Gautvik KM, Schweitzer P, Danielson PE, Dunlop CL, Siggins GR, Henriksen SJ, Sutcliffe JG. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 381: 242-5. PMID 8622767 DOI: 10.1038/381242a0  1
1996 Iniguez MA, De Lecea L, Guadano-Ferraz A, Morte B, Gerendasy D, Sutcliffe JG, Bernal J. Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain. Endocrinology. 137: 1032-41. PMID 8603571 DOI: 10.1210/endo.137.3.8603571  1
1995 de Lecea L, del Río JA, Soriano E. Developmental expression of parvalbumin mRNA in the cerebral cortex and hippocampus of the rat. Brain Research. Molecular Brain Research. 32: 1-13. PMID 7494447  0.72
1994 Usui H, Falk JD, Dopazo A, de Lecea L, Erlander MG, Sutcliffe JG. Isolation of clones of rat striatum-specific mRNAs by directional tag PCR subtraction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4915-26. PMID 8046460  1
1994 Ruiz-Lozano P, de Lecea L, Buesa C, Pérez de la Osa P, LePage D, Gualberto A, Walsh K, Pons G. The gene encoding rat phosphoglycerate mutase subunit M: cloning and promoter analysis in skeletal muscle cells. Gene. 147: 243-8. PMID 7926808  0.52
1994 Danielson PE, Watson JB, Gerendasy DD, Erlander MG, Lovenberg TW, de Lecea L, Sutcliffe JG, Frankel WN. Chromosomal mapping of mouse genes expressed selectively within the central nervous system. Genomics. 19: 454-61. PMID 7910582 DOI: 10.1006/geno.1994.1094  1
1994 del Río JA, de Lecea L, Ferrer I, Soriano E. The development of parvalbumin-immunoreactivity in the neocortex of the mouse. Brain Research. Developmental Brain Research. 81: 247-59. PMID 7813046 DOI: 10.1016/0165-3806(94)90311-5  1
1994 de Lecea L, Soriano E, Criado JR, Steffensen SC, Henriksen SJ, Sutcliffe JG. Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity. Brain Research. Molecular Brain Research. 25: 286-96. PMID 7808228 DOI: 10.1016/0169-328X(94)90164-3  1
1994 Watson JB, Coulter PM, Margulies JE, de Lecea L, Danielson PE, Erlander MG, Sutcliffe JG. G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum. Journal of Neuroscience Research. 39: 108-16. PMID 7807587 DOI: 10.1002/jnr.490390113  1
1993 Lovenberg TW, Baron BM, de Lecea L, Miller JD, Prosser RA, Rea MA, Foye PE, Racke M, Slone AL, Siegel BW. A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 11: 449-58. PMID 8398139 DOI: 10.1016/0896-6273(93)90149-L  1
1993 Erlander MG, Lovenberg TW, Baron BM, de Lecea L, Sutcliffe JG. Molecular approach to hypothalamic rhythms: isolation of novel indoleamine receptor genes. Journal of Biological Rhythms. 8: S25-31. PMID 8274759  1
1993 Erlander MG, Lovenberg TW, Baron BM, de Lecea L, Danielson PE, Racke M, Slone AL, Siegel BW, Foye PE, Cannon K. Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. Proceedings of the National Academy of Sciences of the United States of America. 90: 3452-6. PMID 7682702  1
1992 Graña X, de Lecea L, el-Maghrabi MR, Ureña JM, Caellas C, Carreras J, Puigdomenech P, Pilkis SJ, Climent F. Cloning and sequencing of a cDNA encoding 2,3-bisphosphoglycerate-independent phosphoglycerate mutase from maize. Possible relationship to the alkaline phosphatase family. The Journal of Biological Chemistry. 267: 12797-803. PMID 1535626  1
1992 Ureña JM, Graña X, de Lecea L, Ruiz P, Castellà J, Carreras J, Pons G, Climent F. Isolation and sequencing of a cDNA encoding the B isozyme of rat phosphoglycerate mutase. Gene. 113: 281-2. PMID 1533381 DOI: 10.1016/0378-1119(92)90408-H  1
1992 Soriano E, Del Rio JA, Ferrer I, Auladell C, De Lecea L, Alcantara S. Late appearance of parvalbumin-immunoreactive neurons in the rodent cerebral cortex does not follow an 'inside-out' sequence. Neuroscience Letters. 142: 147-50. PMID 1454208 DOI: 10.1016/0304-3940(92)90360-J  1
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