Laxmikant S. Deshpande - Publications

Affiliations: 
Virginia Commonwealth University School of Medicine, Richmond, VA 
Area:
Epilepsy, Calcium, Cannabinoids, Neurosteroids, Organophosphates

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Phillips KF, Deshpande LS. Calcium Hypothesis of Gulf War Illness: Role of Calcium Ions in Neurological Morbidities in a DFP-Based Rat Model for Gulf War Illness. Neuroscience Insights. 15: 2633105520979841. PMID 33354668 DOI: 10.1177/2633105520979841  1
2020 Deshpande LS, Blair RE, Halquist M, Kosmider L, DeLorenzo RJ. Intramuscular atenolol and levetiracetam reduce mortality in a rat model of paraoxon-induced status epilepticus. Annals of the New York Academy of Sciences. PMID 32961584 DOI: 10.1111/nyas.14500  1
2020 Deshpande LS, DeLorenzo RJ, Churn SB, Parsons JT. Neuronal-Specific Inhibition of Endoplasmic Reticulum Mg/Ca ATPase Ca Uptake in a Mixed Primary Hippocampal Culture Model of Status Epilepticus. Brain Sciences. 10. PMID 32664397 DOI: 10.3390/brainsci10070438  1
2020 Zhu J, Hawkins E, Phillips K, Deshpande LS. Assessment of Ketamine and Its Enantiomers in an Organophosphate-Based Rat Model for Features of Gulf War Illness. International Journal of Environmental Research and Public Health. 17. PMID 32629972 DOI: 10.3390/ijerph17134710  1
2019 Deshpande LS, DeLorenzo RJ. Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis. Neurobiology of Disease. PMID 30872159 DOI: 10.1016/j.nbd.2019.03.006  1
2019 Phillips KF, Santos E, Blair RE, Deshpande LS. Targeting intracellular calcium stores alleviates neurological morbidities in a DFP-based rat model of Gulf War Illness. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30859209 DOI: 10.1093/toxsci/kfz070  1
2018 Phillips KF, Deshpande LS, DeLorenzo RJ. Hypothermia Reduces Mortality, Prevents the Calcium Plateau, and Is Neuroprotective Following Status Epilepticus in Rats. Frontiers in Neurology. 9: 438. PMID 29942282 DOI: 10.3389/fneur.2018.00438  1
2018 Phillips KF, Deshpande LS. Chronic Neurological Morbidities and Elevated Hippocampal Calcium Levels in a DFP-Based Rat Model of Gulf War Illness. Military Medicine. 183: 552-555. PMID 29635560 DOI: 10.1093/milmed/usx148  1
2016 Deshpande LS, Blair RE, Phillips KF, DeLorenzo RJ. Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication. Annals of the New York Academy of Sciences. PMID 27327161 DOI: 10.1111/nyas.13122  1
2016 Deshpande LS, Blair RE, Huang BA, Phillips KF, DeLorenzo RJ. Pharmacological blockade of the calcium plateau provides neuroprotection following organophosphate paraoxon induced status epilepticus in rats. Neurotoxicology and Teratology. PMID 27224207 DOI: 10.1016/j.ntt.2016.05.002  1
2016 Phillips KF, Deshpande LS. Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness. Neurotoxicology. 52: 127-33. PMID 26619911 DOI: 10.1016/j.neuro.2015.11.014  1
2016 Phillips KF, Deshpande LS. Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness Neurotoxicology. 52: 127-133. DOI: 10.1016/j.neuro.2015.11.014  1
2015 Blair RE, Deshpande LS, DeLorenzo RJ. Cannabinoids: is there a potential treatment role in epilepsy? Expert Opinion On Pharmacotherapy. 16: 1911-4. PMID 26234319 DOI: 10.1517/14656566.2015.1074181  1
2015 Blair RE, Deshpande LS, DeLorenzo RJ. Endocannabinoids and epilepsy Cannabinoids in Neurologic and Mental Disease. 125-172. DOI: 10.1016/B978-0-12-417041-4.00006-0  1
2014 Deshpande LS, Phillips K, Huang B, DeLorenzo RJ. Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity. Neurotoxicology. 44: 352-7. PMID 25172410 DOI: 10.1016/j.neuro.2014.08.008  1
2014 Deshpande LS, Carter DS, Phillips KF, Blair RE, DeLorenzo RJ. Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. Neurotoxicology. 44: 17-26. PMID 24785379 DOI: 10.1016/j.neuro.2014.04.006  1
2014 Deshpande LS, Delorenzo RJ. Mechanisms of levetiracetam in the control of status epilepticus and epilepsy. Frontiers in Neurology. 5: 11. PMID 24550884 DOI: 10.3389/fneur.2014.00011  1
2013 Phillips KF, Deshpande LS, DeLorenzo RJ. Hypothermia reduces calcium entry via the N-methyl-D-aspartate and ryanodine receptors in cultured hippocampal neurons. European Journal of Pharmacology. 698: 186-92. PMID 23085028 DOI: 10.1016/j.ejphar.2012.10.010  1
2011 Deshpande LS, Blair RE, DeLorenzo RJ. Prolonged cannabinoid exposure alters GABA(A) receptor mediated synaptic function in cultured hippocampal neurons. Experimental Neurology. 229: 264-73. PMID 21324315 DOI: 10.1016/j.expneurol.2011.02.007  1
2011 Carter DS, Deshpande LS, Rafiq A, Sombati S, DeLorenzo RJ. Characterization of spontaneous recurrent epileptiform discharges in hippocampal-entorhinal cortical slices prepared from chronic epileptic animals. Seizure. 20: 218-24. PMID 21168348 DOI: 10.1016/j.seizure.2010.11.022  1
2011 Ziobro JM, Deshpande LS, Delorenzo RJ. An organotypic hippocampal slice culture model of excitotoxic injury induced spontaneous recurrent epileptiform discharges. Brain Research. 1371: 110-20. PMID 21111720 DOI: 10.1016/j.brainres.2010.11.065  1
2011 Deshpande LS, DeLorenzo RJ. Acetaminophen inhibits status epilepticus in cultured hippocampal neurons. Neuroreport. 22: 15-8. PMID 21037491 DOI: 10.1097/WNR.0b013e3283413231  1
2010 Nagarkatti N, Deshpande LS, Carter DS, DeLorenzo RJ. Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. The European Journal of Neuroscience. 32: 80-8. PMID 20597971 DOI: 10.1111/j.1460-9568.2010.07262.x  1
2010 Deshpande LS, Carter DS, Blair RE, DeLorenzo RJ. Development of a prolonged calcium plateau in hippocampal neurons in rats surviving status epilepticus induced by the organophosphate diisopropylfluorophosphate. Toxicological Sciences : An Official Journal of the Society of Toxicology. 116: 623-31. PMID 20498005 DOI: 10.1093/toxsci/kfq157  1
2009 Blair RE, Deshpande LS, Sombati S, Elphick MR, Martin BR, DeLorenzo RJ. Prolonged exposure to WIN55,212-2 causes downregulation of the CB1 receptor and the development of tolerance to its anticonvulsant effects in the hippocampal neuronal culture model of acquired epilepsy. Neuropharmacology. 57: 208-18. PMID 19540252 DOI: 10.1016/j.neuropharm.2009.06.007  1
2009 Nagarkatti N, Deshpande LS, DeLorenzo RJ. Development of the calcium plateau following status epilepticus: role of calcium in epileptogenesis. Expert Review of Neurotherapeutics. 9: 813-24. PMID 19496685 DOI: 10.1586/ern.09.21  1
2009 Blair RE, Deshpande LS, Holbert WH, Churn SB, DeLorenzo RJ. Age-dependent mortality in the pilocarpine model of status epilepticus. Neuroscience Letters. 453: 233-7. PMID 19429042 DOI: 10.1016/j.neulet.2009.02.035  1
2009 DeLorenzo RJ, Kirmani B, Deshpande LS, Jakkampudi V, Towne AR, Waterhouse E, Garnett L, Ramakrishnan V. Comparisons of the mortality and clinical presentations of status epilepticus in private practice community and university hospital settings in Richmond, Virginia. Seizure. 18: 405-11. PMID 19324574 DOI: 10.1016/j.seizure.2009.02.005  1
2008 Blank M, Deshpande L, Balster RL. Availability and characteristics of betel products in the U.S. Journal of Psychoactive Drugs. 40: 309-13. PMID 19004423 DOI: 10.1080/02791072.2008.10400646  1
2008 Deshpande LS, Sun DA, Sombati S, Baranova A, Wilson MS, Attkisson E, Hamm RJ, DeLorenzo RJ. Alterations in neuronal calcium levels are associated with cognitive deficits after traumatic brain injury. Neuroscience Letters. 441: 115-9. PMID 18583041 DOI: 10.1016/j.neulet.2008.05.113  1
2008 Deshpande LS, Nagarkatti N, Ziobro JM, Sombati S, DeLorenzo RJ. Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons. Epilepsia. 49: 1795-802. PMID 18494784 DOI: 10.1111/j.1528-1167.2008.01667.x  1
2008 Nagarkatti N, Deshpande LS, DeLorenzo RJ. Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neuroscience Letters. 436: 289-93. PMID 18406528 DOI: 10.1016/j.neulet.2008.02.076  1
2008 Sun DA, Deshpande LS, Sombati S, Baranova A, Wilson MS, Hamm RJ, DeLorenzo RJ. Traumatic brain injury causes a long-lasting calcium (Ca2+)-plateau of elevated intracellular Ca levels and altered Ca2+ homeostatic mechanisms in hippocampal neurons surviving brain injury. The European Journal of Neuroscience. 27: 1659-72. PMID 18371074 DOI: 10.1111/j.1460-9568.2008.06156.x  1
2008 Deshpande LS, Nagarkatti N, Sombati S, DeLorenzo RJ. The novel antiepileptic drug carisbamate (RWJ 333369) is effective in inhibiting spontaneous recurrent seizure discharges and blocking sustained repetitive firing in cultured hippocampal neurons. Epilepsy Research. 79: 158-65. PMID 18353614 DOI: 10.1016/j.eplepsyres.2008.01.002  1
2008 Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, Attkisson E, DeLorenzo RJ. Time course and mechanism of hippocampal neuronal death in an in vitro model of status epilepticus: role of NMDA receptor activation and NMDA dependent calcium entry. European Journal of Pharmacology. 583: 73-83. PMID 18289526 DOI: 10.1016/j.ejphar.2008.01.025  1
2007 Deshpande LS, Lou JK, Mian A, Blair RE, Sombati S, DeLorenzo RJ. In vitro status epilepticus but not spontaneous recurrent seizures cause cell death in cultured hippocampal neurons. Epilepsy Research. 75: 171-9. PMID 17624736 DOI: 10.1016/j.eplepsyres.2007.05.011  1
2007 Deshpande LS, Limbrick DD, Sombati S, DeLorenzo RJ. Activation of a novel injury-induced calcium-permeable channel that plays a key role in causing extended neuronal depolarization and initiating neuronal death in excitotoxic neuronal injury. The Journal of Pharmacology and Experimental Therapeutics. 322: 443-52. PMID 17483292 DOI: 10.1124/jpet.107.123182  1
2007 Raza M, Deshpande LS, Blair RE, Carter DS, Sombati S, DeLorenzo RJ. Aging is associated with elevated intracellular calcium levels and altered calcium homeostatic mechanisms in hippocampal neurons. Neuroscience Letters. 418: 77-81. PMID 17374449 DOI: 10.1016/j.neulet.2007.03.005  1
2007 Deshpande LS, Blair RE, Nagarkatti N, Sombati S, Martin BR, DeLorenzo RJ. Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus. Experimental Neurology. 204: 705-13. PMID 17289026 DOI: 10.1016/j.expneurol.2007.01.001  1
2007 Deshpande LS, Blair RE, Ziobro JM, Sombati S, Martin BR, DeLorenzo RJ. Endocannabinoids block status epilepticus in cultured hippocampal neurons. European Journal of Pharmacology. 558: 52-9. PMID 17174949 DOI: 10.1016/j.ejphar.2006.11.030  1
2007 Deshpande LS, Sombati S, Blair RE, Carter DS, Martin BR, DeLorenzo RJ. Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy. Neuroscience Letters. 411: 11-6. PMID 17110038 DOI: 10.1016/j.neulet.2006.09.046  1
2006 Carter DS, Haider SN, Blair RE, Deshpande LS, Sombati S, DeLorenzo RJ. Altered calcium/calmodulin kinase II activity changes calcium homeostasis that underlies epileptiform activity in hippocampal neurons in culture. The Journal of Pharmacology and Experimental Therapeutics. 319: 1021-31. PMID 16971505 DOI: 10.1124/jpet.106.110403  1
2006 DeLorenzo RJ, Sun DA, Deshpande LS. Erratum to "Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy." [Pharmacol. Ther. 105(3) (2005) 229-266]. Pharmacology & Therapeutics. 111: 288-325. PMID 16832874  1
2006 Blair RE, Deshpande LS, Sombati S, Falenski KW, Martin BR, DeLorenzo RJ. Activation of the cannabinoid type-1 receptor mediates the anticonvulsant properties of cannabinoids in the hippocampal neuronal culture models of acquired epilepsy and status epilepticus. The Journal of Pharmacology and Experimental Therapeutics. 317: 1072-8. PMID 16469864 DOI: 10.1124/jpet.105.100354  1
2005 Delorenzo RJ, Sun DA, Deshpande LS. Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintainance of epilepsy. Pharmacology & Therapeutics. 105: 229-66. PMID 15737406 DOI: 10.1016/j.pharmthera.2004.10.004  1
2004 Raza M, Blair RE, Sombati S, Carter DS, Deshpande LS, DeLorenzo RJ. Evidence that injury-induced changes in hippocampal neuronal calcium dynamics during epileptogenesis cause acquired epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 101: 17522-7. PMID 15583136 DOI: 10.1073/pnas.0408155101  1
2002 Khisti RT, Deshpande LS, Chopde CT. The neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one affects dopamine-mediated behavior in rodents. Psychopharmacology. 161: 120-8. PMID 11981591 DOI: 10.1007/s00213-002-1006-5  1
2001 Deshpande LS, Khisti RT, Chopde CT. Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents. Brain Research. 898: 13-26. PMID 11292445 DOI: 10.1016/S0006-8993(01)02117-5  1
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