William A. Beltran, Ph.D. - Publications

Affiliations: 
2006 Cornell University, Ithaca, NY, United States 
Area:
Neuroscience Biology, Animal Physiology Biology, Veterinary Science Biology

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Cideciyan AV, Jacobson SG, Roman AJ, Sumaroka A, Wu V, Charng J, Lisi B, Swider M, Aguirre GD, Beltran WA. Rod function deficit in retained photoreceptors of patients with class B Rhodopsin mutations. Scientific Reports. 10: 12552. PMID 32724127 DOI: 10.1038/s41598-020-69456-3  0.72
2020 Song C, Dufour VLL, Cideciyan AV, Ye GJ, Swider M, Newmark J, Timmers A, Robinson P, Knop DR, Chulay JD, Jacobson S, Aguirre G, Beltran W, Shearman MS. Dose Range Finding Studies with Two RPGR Transgenes in a Canine Model of X-linked Retinitis Pigmentosa Treated with Subretinal Gene Therapy. Human Gene Therapy. PMID 32414297 DOI: 10.1089/hum.2019.337  0.36
2020 Dufour VL, Yu Y, Pan W, Ying GS, Aguirre GD, Beltran WA. In-vivo longitudinal changes in thickness of the canine postnatal retina. Experimental Eye Research. 107926. PMID 31931002 DOI: 10.1016/j.exer.2020.107926  0.72
2020 Dufour VLL, Cideciyan AV, Ye GJ, Song C, Timmers A, Habecker P, Pan W, Weinstein N, Swider M, Durham A, Ying GS, Robinson P, Jacobson S, Knop DR, Chulay JD, ... ... Beltran W, et al. Toxicity and Efficacy Evaluation of an AAV Vector Expressing Codon-Optimized RPGR Delivered by Subretinal Injection in a Canine Model of X-linked Retinitis Pigmentosa. Human Gene Therapy. PMID 31910043 DOI: 10.1089/hum.2019.297  0.36
2019 Sudharsan R, Beltran WA. Progress in Gene Therapy for Rhodopsin Autosomal Dominant Retinitis Pigmentosa. Advances in Experimental Medicine and Biology. 1185: 113-118. PMID 31884598 DOI: 10.1007/978-3-030-27378-1_19  0.72
2019 Iwabe S, Dufour VL, Guzmán JM, Holle DM, Cohen JA, Beltran WA, Aguirre GD. Focal/multifocal and geographic retinal dysplasia in the dog-In vivo retinal microanatomy analyses. Veterinary Ophthalmology. PMID 31746146 DOI: 10.1111/vop.12725  0.72
2019 Gardiner KL, Cideciyan AV, Swider M, Dufour VL, Sumaroka A, Komáromy AM, Hauswirth WW, Iwabe S, Jacobson SG, Beltran WA, Aguirre GD. Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31604676 DOI: 10.1016/j.ymthe.2019.08.013  0.72
2018 Sudharsan R, Beiting DP, Aguirre GD, Beltran WA. Author Correction: Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Scientific Reports. 8: 17041. PMID 30429513 DOI: 10.1038/s41598-018-35520-2  0.72
2018 Hardcastle AJ, Sieving PA, Sahel JA, Jacobson SG, Cideciyan AV, Flannery JG, Beltran WA, Aguirre GD. Translational Retinal Research and Therapies. Translational Vision Science & Technology. 7: 8. PMID 30225158 DOI: 10.1167/tvst.7.5.8  0.72
2018 Léger H, Santana E, Leu NA, Smith ET, Beltran WA, Aguirre GD, Luca FC. Ndr kinases regulate retinal interneuron proliferation and homeostasis. Scientific Reports. 8: 12544. PMID 30135513 DOI: 10.1038/s41598-018-30492-9  0.72
2018 Cideciyan AV, Sudharsan R, Dufour VL, Massengill MT, Iwabe S, Swider M, Lisi B, Sumaroka A, Marinho LF, Appelbaum T, Rossmiller B, Hauswirth WW, Jacobson SG, Lewin AS, Aguirre GD, ... Beltran WA, et al. Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127005 DOI: 10.1073/pnas.1805055115  0.72
2018 Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA. Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay. Advances in Experimental Medicine and Biology. 1074: 593-601. PMID 29721992 DOI: 10.1007/978-3-319-75402-4_72  0.72
2018 Guziewicz KE, Cideciyan AV, Beltran WA, Komáromy AM, Dufour VL, Swider M, Iwabe S, Sumaroka A, Kendrick BT, Ruthel G, Chiodo VA, Héon E, Hauswirth WW, Jacobson SG, Aguirre GD. gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507198 DOI: 10.1073/pnas.1720662115  0.72
2017 Sudharsan R, Beiting DP, Aguirre GD, Beltran WA. Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration. Scientific Reports. 7: 17897. PMID 29263354 DOI: 10.1038/s41598-017-18236-7  0.72
2017 Beltran WA, Cideciyan AV, Boye SE, Ye GJ, Iwabe S, Dufour VL, Marinho LF, Swider M, Kosyk MS, Sha J, Boye SL, Peterson JJ, Witherspoon CD, Alexander JJ, Ying GS, et al. Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28566226 DOI: 10.1016/j.ymthe.2017.05.004  0.72
2017 Sudharsan R, Simone KM, Anderson NP, Aguirre GD, Beltran WA. Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa. Investigative Ophthalmology & Visual Science. 58: 270-281. PMID 28114588 DOI: 10.1167/iovs.16-20749  0.72
2016 Downs LM, Scott EM, Cideciyan AV, Iwabe S, Dufour V, Gardiner KL, Genini S, Marinho LF, Sumaroka A, Kosyk MS, Swider M, Aguirre GK, Jacobson SG, Beltran WA, Aguirre GD. Overlap of Abnormal Photoreceptor Development and Progressive Degeneration in Leber Congenital Amaurosis Caused by NPHP5 Mutation. Human Molecular Genetics. PMID 27506978 DOI: 10.1093/hmg/ddw254  0.72
2016 Iwabe S, Ying GS, Aguirre GD, Beltran WA. Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog. Experimental Eye Research. 146: 341-353. PMID 27085210 DOI: 10.1016/j.exer.2016.04.006  0.72
2016 Byrne LC, Visel M, Dufour V, Marinho FP, Aguirre GD, Beltran WA, Flannery JG, Schaffer DV. 617. Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery Molecular Therapy. 24: S244-S245. DOI: 10.1016/S1525-0016(16)33425-6  0.72
2015 Beltran WA, Cideciyan AV, Iwabe S, Swider M, Kosyk MS, McDaid K, Martynyuk I, Ying GS, Shaffer J, Deng WT, Boye SL, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease. Proceedings of the National Academy of Sciences of the United States of America. 112: E5844-53. PMID 26460017 DOI: 10.1073/pnas.1509914112  0.52
2015 Marsili S, Genini S, Sudharsan R, Gingrich J, Aguirre GD, Beltran WA. Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa. Plos One. 10: e0115723. PMID 25695253 DOI: 10.1371/journal.pone.0115723  0.52
2015 Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD. Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR. Cold Spring Harbor Perspectives in Medicine. 5: a017392. PMID 25301933 DOI: 10.1101/cshperspect.a017392  0.52
2014 Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5574-83. PMID 25489083 DOI: 10.1073/pnas.1414162111  0.52
2014 Genini S, Beltran WA, Stein VM, Aguirre GD. Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina. Advances in Experimental Medicine and Biology. 801: 339-45. PMID 24664716 DOI: 10.1007/978-1-4614-3209-8_43  0.52
2014 Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD. Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations. Plos One. 9: e90390. PMID 24599007 DOI: 10.1371/journal.pone.0090390  0.72
2014 Genini S, Guziewicz KE, Beltran WA, Aguirre GD. Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration. Bmc Genomics. 15: 172. PMID 24581223 DOI: 10.1186/1471-2164-15-172  0.72
2014 GUZIEWICZ K, BELTRAN W, CIDECIYAN A, KOMÁROMY A, IWABE S, DUTROW E, ZANGERL B, HAUSWIRTH W, JACOBSON S, AGUIRRE G. Gene therapy for bestrophinopathies Acta Ophthalmologica. 92: 0-0. DOI: 10.1111/j.1755-3768.2014.3264.x  0.6
2013 Genini S, Beltran WA, Aguirre GD. Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration. Plos One. 8: e85408. PMID 24367709 DOI: 10.1371/journal.pone.0085408  0.72
2013 Guziewicz KE, Zangerl B, Komáromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD. Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects. Plos One. 8: e75666. PMID 24143172 DOI: 10.1371/journal.pone.0075666  0.52
2013 Cideciyan AV, Jacobson SG, Beltran WA, Hauswirth WW, Aguirre GD. Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration. Proceedings of the National Academy of Sciences of the United States of America. 110: E1706. PMID 23789127 DOI: 10.1073/pnas.1304296110  0.52
2013 Komáromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD. Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1131-41. PMID 23568263 DOI: 10.1038/mt.2013.50  0.52
2013 Cideciyan AV, Jacobson SG, Beltran WA, Sumaroka A, Swider M, Iwabe S, Roman AJ, Olivares MB, Schwartz SB, Komáromy AM, Hauswirth WW, Aguirre GD. Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement. Proceedings of the National Academy of Sciences of the United States of America. 110: E517-25. PMID 23341635 DOI: 10.1073/pnas.1218933110  0.52
2012 Beltran WA, Cideciyan AV, Lewin AS, Iwabe S, Khanna H, Sumaroka A, Chiodo VA, Fajardo DS, Román AJ, Deng WT, Swider M, Alemán TS, Boye SL, Genini S, Swaroop A, et al. Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 109: 2132-7. PMID 22308428 DOI: 10.1073/pnas.1118847109  0.52
2012 Genini S, Beltran WA, Aguirre GD. Development and validation of a canine-specific profiling array to examine expression of pro-apoptotic and pro-survival genes in retinal degenerative diseases. Advances in Experimental Medicine and Biology. 723: 353-63. PMID 22183353 DOI: 10.1007/978-1-4614-0631-0_46  0.72
2011 Berta ÁI, Boesze-Battaglia K, Genini S, Goldstein O, O'Brien PJ, Szél Á, Acland GM, Beltran WA, Aguirre GD. Photoreceptor cell death, proliferation and formation of hybrid rod/S-cone photoreceptors in the degenerating STK38L mutant retina. Plos One. 6: e24074. PMID 21980341 DOI: 10.1371/journal.pone.0024074  0.72
2010 Genini S, Zangerl B, Slavik J, Acland GM, Beltran WA, Aguirre GD. Transcriptional profile analysis of RPGRORF15 frameshift mutation identifies novel genes associated with retinal degeneration. Investigative Ophthalmology & Visual Science. 51: 6038-50. PMID 20574030 DOI: 10.1167/iovs.10-5443  0.72
2010 Beltran WA, Boye SL, Boye SE, Chiodo VA, Lewin AS, Hauswirth WW, Aguirre GD. rAAV2/5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters. Gene Therapy. 17: 1162-74. PMID 20428215 DOI: 10.1038/gt.2010.56  0.52
2009 Beltran WA, Allore HG, Johnson E, Towle V, Tao W, Acland GM, Aguirre GD, Zeiss CJ. CREB1/ATF1 activation in photoreceptor degeneration and protection. Investigative Ophthalmology & Visual Science. 50: 5355-63. PMID 19643965 DOI: 10.1167/iovs.09-3741  0.72
2009 Beltran WA, Acland GM, Aguirre GD. Age-dependent disease expression determines remodeling of the retinal mosaic in carriers of RPGR exon ORF15 mutations. Investigative Ophthalmology & Visual Science. 50: 3985-95. PMID 19255154 DOI: 10.1167/iovs.08-3364  0.72
2009 Gu D, Beltran WA, Pearce-Kelling S, Li Z, Acland GM, Aguirre GD. Steroids do not prevent photoreceptor degeneration in the light-exposed T4R rhodopsin mutant dog retina irrespective of AP-1 inhibition. Investigative Ophthalmology & Visual Science. 50: 3482-94. PMID 19234347 DOI: 10.1167/iovs.08-3111  0.72
2007 Gu D, Beltran WA, Li Z, Acland GM, Aguirre GD. Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina? Investigative Ophthalmology & Visual Science. 48: 4907-18. PMID 17962438 DOI: 10.1167/iovs.07-0428  0.72
2007 Jacobson SG, Aleman TS, Cideciyan AV, Heon E, Golczak M, Beltran WA, Sumaroka A, Schwartz SB, Roman AJ, Windsor EA, Wilson JM, Aguirre GD, Stone EM, Palczewski K. Human cone photoreceptor dependence on RPE65 isomerase. Proceedings of the National Academy of Sciences of the United States of America. 104: 15123-8. PMID 17848510 DOI: 10.1073/pnas.0706367104  0.72
2007 Beltran WA, Wen R, Acland GM, Aguirre GD. Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina. Experimental Eye Research. 84: 753-71. PMID 17320077 DOI: 10.1016/j.exer.2006.12.019  0.52
2006 Beltran WA, Hammond P, Acland GM, Aguirre GD. A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa. Investigative Ophthalmology & Visual Science. 47: 1669-81. PMID 16565408 DOI: 10.1167/iovs.05-0845  0.72
2005 Beltran WA, Rohrer H, Aguirre GD. Immunolocalization of ciliary neurotrophic factor receptor alpha (CNTFRalpha) in mammalian photoreceptor cells. Molecular Vision. 11: 232-44. PMID 15827545  0.52
2003 Zhang Q, Beltran WA, Mao Z, Li K, Johnson JL, Acland GM, Aguirre GD. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. Investigative Ophthalmology & Visual Science. 44: 4542-9. PMID 14507903 DOI: 10.1167/iovs.02-1202  0.72
2003 Beltran WA, Zhang Q, Kijas JW, Gu D, Rohrer H, Jordan JA, Aguirre GD. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Investigative Ophthalmology & Visual Science. 44: 3642-9. PMID 12882818 DOI: 10.1167/iovs.02-0763  0.52
2001 BELTRÁN W, KATTAN G. FIRST RECORD OF THE SLATY-BACKED NIGHTINGALE-THRUSH IN THE CENTRAL ANDES OF COLOMBIA, WITH NOTES ON ITS ECOLOGY AND GEOGRAPHICAL VARIATION The Wilson Bulletin. 113: 134-139. DOI: 10.1676/0043-5643(2001)113[0134:FROTSB]2.0.CO;2  0.32
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