| Year |
Citation |
Score |
| 2022 |
Rocha SM, Bantle CM, Aboellail T, Chatterjee D, Smeyne RJ, Tjalkens RB. Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice. Neurobiology of Disease. 167: 105685. PMID 35257879 DOI: 10.1016/j.nbd.2022.105685 |
0.302 |
|
| 2021 |
Bantle CM, Rocha SM, French CT, Phillips AT, Tran K, Olson KE, Bass TA, Aboellail T, Smeyne RJ, Tjalkens RB. Astrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis. Experimental Neurology. 346: 113845. PMID 34454938 DOI: 10.1016/j.expneurol.2021.113845 |
0.325 |
|
| 2020 |
Hammond SL, Bantle CM, Popichak KA, Wright KA, Thompson D, Forero C, Kirkley KS, Damale PU, Chong EKP, Tjalkens RB. NF-κB signaling in astrocytes modulates brain inflammation and neuronal injury following sequential exposure to manganese and MPTP during development and aging. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 32692843 DOI: 10.1093/Toxsci/Kfaa115 |
0.448 |
|
| 2019 |
Karki K, Li X, Jin UH, Mohankumar K, Zarei M, Michelhaugh SK, Mittal S, Tjalkens R, Safe S. Nuclear receptor 4A2 (NR4A2) is a druggable target for glioblastomas. Journal of Neuro-Oncology. PMID 31754919 DOI: 10.1007/S11060-019-03349-Y |
0.345 |
|
| 2019 |
Bantle CM, Phillips AT, Smeyne RJ, Rocha SM, Olson KE, Tjalkens RB. Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation. Npj Parkinson's Disease. 5: 20. PMID 31531390 DOI: 10.1038/S41531-019-0090-8 |
0.388 |
|
| 2019 |
Li X, Tjalkens RB, Shrestha R, Safe S. Structure-dependent Activation of Gene Expression by Bis-indole and Quinoline-derived Activators of Nuclear Receptor 4A2. Chemical Biology & Drug Design. PMID 31102570 DOI: 10.1111/Cbdd.13564 |
0.357 |
|
| 2019 |
Kirkley KS, Popichak KA, Hammond SL, Davies C, Hunt L, Tjalkens RB. Genetic suppression of IKK2/NF-κB in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease. Neurobiology of Disease. PMID 30818064 DOI: 10.1016/J.Nbd.2019.02.020 |
0.422 |
|
| 2018 |
Popichak KA, Afzali MF, Kirkley KS, Tjalkens RB. Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese. Journal of Neuroinflammation. 15: 1-15. PMID 30463564 DOI: 10.1186/S12974-018-1349-4 |
0.459 |
|
| 2018 |
Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB. Compensatory expression of Nur77 and Nurr1 regulates NF-κB-dependent inflammatory signaling in astrocytes. Molecular Pharmacology. PMID 30111648 DOI: 10.1124/mol.118.112631 |
0.331 |
|
| 2018 |
Afzali MF, Popichak KA, Burton LH, Klochak AL, Wilson WJ, Safe S, Tjalkens RB, Legare ME. A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism. Molecular Immunology. 101: 46-54. PMID 29870816 DOI: 10.1016/J.Molimm.2018.05.024 |
0.377 |
|
| 2018 |
Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale P, Chong E, Backos DS, Safe S, Tjalkens RB. The Nurr1 ligand,1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane, modulates glial reactivity and is neuroprotective in MPTP-induced parkinsonism. The Journal of Pharmacology and Experimental Therapeutics. PMID 29626009 DOI: 10.1124/Jpet.117.246389 |
0.459 |
|
| 2018 |
Popichak KA, Afzali MF, Kirkley KS, Tjalkens RB. Glial-neuronal signaling mechanisms underlying the neurotoxic effects of manganese Toxicology Letters. 295. DOI: 10.1016/J.Toxlet.2018.06.049 |
0.335 |
|
| 2017 |
Hammond SL, Leek AN, Richman EH, Tjalkens RB. Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. Plos One. 12: e0188830. PMID 29244806 DOI: 10.1371/Journal.Pone.0188830 |
0.399 |
|
| 2017 |
Tjalkens RB, Popichak KA, Kirkley KA. Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity Advances in Neurobiology. 18: 159-181. PMID 28889267 DOI: 10.1007/978-3-319-60189-2_8 |
0.418 |
|
| 2017 |
Kirkley KS, Popichak KA, Afzali MF, Legare ME, Tjalkens RB. Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity. Journal of Neuroinflammation. 14: 99. PMID 28476157 DOI: 10.1186/S12974-017-0871-0 |
0.397 |
|
| 2016 |
Wilson WJ, Afzali MF, Cummings JE, Legare ME, Tjalkens RB, Allen CP, Slayden RA, Hanneman WH. Immune Modulation as an Effective Adjunct Post-exposure Therapeutic for B. pseudomallei. Plos Neglected Tropical Diseases. 10: e0005065. PMID 27792775 DOI: 10.1371/Journal.Pntd.0005065 |
0.354 |
|
| 2016 |
Phillips AT, Rico AB, Stauft CB, Hammond SL, Aboellail TA, Tjalkens RB, Olson KE. ENTRY SITES OF VENEZUELAN AND WESTERN EQUINE ENCEPHALITIS VIRUSES IN THE MOUSE CENTRAL NERVOUS SYSTEM FOLLOWING PERIPHERAL INFECTION. Journal of Virology. PMID 27053560 DOI: 10.1128/Jvi.03219-15 |
0.336 |
|
| 2016 |
Ashley AK, Hinds AI, Hanneman WH, Tjalkens RB, Legare ME. DJ-1 mutation decreases astroglial release of inflammatory mediators Neurotoxicology. 52: 198-203. DOI: 10.1016/J.Neuro.2015.12.007 |
0.419 |
|
| 2015 |
Hammond SL, Safe S, Tjalkens RB. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neuroscience Letters. 607: 83-9. PMID 26383113 DOI: 10.1016/J.Neulet.2015.09.015 |
0.436 |
|
| 2015 |
Li W, Liu J, Hammond SL, Tjalkens RB, Saifudeen Z, Feng Y. Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R138-47. PMID 25994957 DOI: 10.1152/Ajpregu.00319.2014 |
0.332 |
|
| 2015 |
De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S, Tjalkens RB. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Molecular Pharmacology. 87: 1021-34. PMID 25858541 DOI: 10.1124/Mol.114.095398 |
0.412 |
|
| 2015 |
De Miranda BR, Popichak KA, Hammond SL, Miller JA, Safe S, Tjalkens RB. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 360-73. PMID 25406165 DOI: 10.1093/Toxsci/Kfu236 |
0.468 |
|
| 2014 |
Streifel KM, Gonzales AL, De Miranda B, Mouneimne R, Earley S, Tjalkens R. Dopaminergic neurotoxicants cause biphasic inhibition of purinergic calcium signaling in astrocytes Plos One. 9. PMID 25365260 DOI: 10.1371/Journal.Pone.0110996 |
0.36 |
|
| 2014 |
Kirkley KS, Madl JE, Duncan C, Gulland FM, Tjalkens RB. Domoic acid-induced seizures in California sea lions (Zalophus californianus) are associated with neuroinflammatory brain injury. Aquatic Toxicology (Amsterdam, Netherlands). 156: 259-68. PMID 25286249 DOI: 10.1016/J.Aquatox.2014.09.003 |
0.366 |
|
| 2014 |
Miller JA, Kirkley KA, Padmanabhan R, Liang LP, Raol YH, Patel M, Bialecki RA, Tjalkens RB. Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice. Neurotoxicology. 44: 39-47. PMID 24813937 DOI: 10.1016/J.Neuro.2014.04.010 |
0.412 |
|
| 2013 |
De Miranda BR, Miller JA, Hansen RJ, Lunghofer PJ, Safe S, Gustafson DL, Colagiovanni D, Tjalkens RB. Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 345: 125-38. PMID 23318470 DOI: 10.1124/Jpet.112.201558 |
0.322 |
|
| 2013 |
Streifel KM, Miller J, Mouneimne R, Tjalkens RB. Manganese inhibits ATP-induced calcium entry through the transient receptor potential channel TRPC3 in astrocytes. Neurotoxicology. 34: 160-6. PMID 23131343 DOI: 10.1016/J.Neuro.2012.10.014 |
0.366 |
|
| 2012 |
Streifel KM, Moreno JA, Hanneman WH, Legare ME, Tjalkens RB. Gene deletion of nos2 protects against manganese-induced neurological dysfunction in juvenile mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 183-92. PMID 22174044 DOI: 10.1093/Toxsci/Kfr335 |
0.459 |
|
| 2011 |
Polunas M, Halladay A, Tjalkens RB, Philbert MA, Lowndes H, Reuhl K. Role of oxidative stress and the mitochondrial permeability transition in methylmercury cytotoxicity Neurotoxicology. 32: 526-534. PMID 21871920 DOI: 10.1016/J.Neuro.2011.07.006 |
0.408 |
|
| 2011 |
Tjalkens RB, Carbone DL, Wu G. Detection of nitric oxide formation in primary neural cells and tissues. Methods in Molecular Biology (Clifton, N.J.). 758: 267-77. PMID 21815072 DOI: 10.1007/978-1-61779-170-3_18 |
0.342 |
|
| 2011 |
Miller JA, Runkle SA, Tjalkens RB, Philbert MA. 1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex. Toxicological Sciences : An Official Journal of the Society of Toxicology. 122: 502-11. PMID 21551353 DOI: 10.1093/Toxsci/Kfr102 |
0.333 |
|
| 2011 |
Moreno JA, Streifel KM, Sullivan KA, Hanneman WH, Tjalkens RB. Manganese-induced NF-kappaB activation and nitrosative stress is decreased by estrogen in juvenile mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 122: 121-33. PMID 21512103 DOI: 10.1093/Toxsci/Kfr091 |
0.427 |
|
| 2011 |
Miller JA, Trout BR, Sullivan KA, Bialecki RA, Roberts RA, Tjalkens RB. Low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine causes inflammatory activation of astrocytes in nuclear factor-κB reporter mice prior to loss of dopaminergic neurons. Journal of Neuroscience Research. 89: 406-17. PMID 21259327 DOI: 10.1002/Jnr.22549 |
0.457 |
|
| 2010 |
Roberts RA, Smith RA, Safe S, Szabo C, Tjalkens RB, Robertson FM. Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. Toxicology. 276: 85-94. PMID 20643181 DOI: 10.1016/J.Tox.2010.07.009 |
0.322 |
|
| 2009 |
Moreno JA, Streifel KM, Sullivan KA, Legare ME, Tjalkens RB. Developmental exposure to manganese increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 405-15. PMID 19812365 DOI: 10.1093/Toxsci/Kfp221 |
0.45 |
|
| 2009 |
Moreno JA, Yeomans EC, Streifel KM, Brattin BL, Taylor RJ, Tjalkens RB. Age-dependent susceptibility to manganese-induced neurological dysfunction. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 394-404. PMID 19812362 DOI: 10.1093/Toxsci/Kfp220 |
0.307 |
|
| 2009 |
Aschner M, Erikson KM, Herrero Hernández E, Hernández EH, Tjalkens R. Manganese and its role in Parkinson's disease: from transport to neuropathology. Neuromolecular Medicine. 11: 252-66. PMID 19657747 DOI: 10.1007/S12017-009-8083-0 |
0.371 |
|
| 2009 |
Ashley AK, Hanneman WH, Katoh T, Moreno JA, Pollack A, Tjalkens RB, Legare ME. Analysis of targeted mutation in DJ-1 on cellular function in primary astrocytes. Toxicology Letters. 184: 186-91. PMID 19063952 DOI: 10.1016/J.Toxlet.2008.11.008 |
0.37 |
|
| 2009 |
Carbone DL, Popichak KA, Moreno JA, Safe S, Tjalkens RB. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular Pharmacology. 75: 35-43. PMID 18840677 DOI: 10.1124/Mol.108.050781 |
0.46 |
|
| 2008 |
Carbone DL, Moreno JA, Tjalkens RB. Nuclear factor kappa-B mediates selective induction of neuronal nitric oxide synthase in astrocytes during low-level inflammatory stimulation with MPTP. Brain Research. 1217: 1-9. PMID 18508038 DOI: 10.1016/J.Brainres.2008.03.093 |
0.419 |
|
| 2008 |
Moreno JA, Sullivan KA, Carbone DL, Hanneman WH, Tjalkens RB. Manganese potentiates nuclear factor-kappaB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular responsive kinase signaling pathways. Journal of Neuroscience Research. 86: 2028-38. PMID 18335517 DOI: 10.1002/Jnr.21640 |
0.412 |
|
| 2008 |
Tjalkens RB, Liu X, Mohl B, Wright T, Moreno JA, Carbone DL, Safe S. The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. Journal of Neuroscience Research. 86: 618-29. PMID 18041089 DOI: 10.1002/Jnr.21524 |
0.454 |
|
| 2006 |
Liu X, Sullivan KA, Madl JE, Legare M, Tjalkens RB. Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration. Toxicological Sciences : An Official Journal of the Society of Toxicology. 91: 521-31. PMID 16551646 DOI: 10.1093/Toxsci/Kfj150 |
0.436 |
|
| 2005 |
Liu X, Buffington JA, Tjalkens RB. NF-kappaB-dependent production of nitric oxide by astrocytes mediates apoptosis in differentiated PC12 neurons following exposure to manganese and cytokines. Brain Research. Molecular Brain Research. 141: 39-47. PMID 16168523 DOI: 10.1016/J.Molbrainres.2005.07.017 |
0.442 |
|
| 2005 |
Ng Y, Barhoumi R, Tjalkens RB, Fan YY, Kolar S, Wang N, Lupton JR, Chapkin RS. The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Carcinogenesis. 26: 1914-21. PMID 15975958 DOI: 10.1093/Carcin/Bgi163 |
0.32 |
|
| 2004 |
Barhoumi R, Faske J, Liu X, Tjalkens RB. Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB. Brain Research. Molecular Brain Research. 122: 167-79. PMID 15010209 DOI: 10.1016/J.Molbrainres.2003.12.009 |
0.415 |
|
| 2004 |
Barhoumi R, Faske J, Liu X, Tjalkens RB. Erratum to “Manganese potentiates lipopolysaccharide-induced expression of NOS2 in C6 glioma cells through mitochondrial-dependent activation of nuclear factor kappaB” [Mol. Brain Res., 122 (2004) 167–179] Molecular Brain Research. 126: 103-105. DOI: 10.1016/J.Molbrainres.2004.03.002 |
0.367 |
|
| 2003 |
Tjalkens RB, Phelka AD, Philbert MA. Regional variation in the activation threshold for 1,3-DNB-induced mitochondrial permeability transition in brainstem and cortical astrocytes. Neurotoxicology. 24: 391-401. PMID 12782104 DOI: 10.1016/S0161-813X(03)00012-3 |
0.393 |
|
| 2003 |
Miller TJ, Phelka AD, Tjalkens RB, Dethloff LA, Philbert MA. CI-1010 induced opening of the mitochondrial permeability transition pore precedes oxidative stress and apoptosis in SY5Y neuroblastoma cells. Brain Research. 963: 43-56. PMID 12560110 DOI: 10.1016/S0006-8993(02)03838-6 |
0.323 |
|
| 2000 |
Tjalkens RB, Ewing MM, Philbert MA. Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy. Brain Research. 874: 165-77. PMID 10960601 DOI: 10.1016/S0006-8993(00)02546-4 |
0.361 |
|
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