Aleister Saunders - Publications

Drexel University, Philadelphia, PA, United States 
Neuroscience Biology, Genetics, Molecular Biology

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ward J, Wang H, Saunders AJ, Tanzi RE, Zhang C. Mechanisms that synergistically regulate η-secretase processing of APP and Aη-α protein levels: relevance to pathogenesis and treatment of Alzheimer's disease. Discovery Medicine. 23: 121-128. PMID 28371615  0.44
2015 Crenshaw E, Leung BP, Kwok CK, Sharoni M, Olson K, Sebastian NP, Ansaloni S, Schweitzer-Stenner R, Akins MR, Bevilacqua PC, Saunders AJ. Amyloid Precursor Protein Translation Is Regulated by a 3'UTR Guanine Quadruplex. Plos One. 10: e0143160. PMID 26618502 DOI: 10.1371/journal.pone.0143160  0.76
2015 Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Correction to Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. PMID 26348101 DOI: 10.1021/acs.biochem.5b00968  0.44
2015 Wang H, Sang N, Zhang C, Raghupathi R, Tanzi RE, Saunders A. Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments. Biochemistry. 54: 2806-16. PMID 25910068 DOI: 10.1021/acs.biochem.5b00329  0.76
2014 Vorobyeva AG, Lee R, Miller S, Longen C, Sharoni M, Kandelwal PJ, Kim FJ, Marenda DR, Saunders AJ. Cyclopamine modulates γ-secretase-mediated cleavage of amyloid precursor protein by altering its subcellular trafficking and lysosomal degradation. The Journal of Biological Chemistry. 289: 33258-74. PMID 25281744 DOI: 10.1074/jbc.M114.591792  0.76
2014 Mhatre SD, Michelson SJ, Gomes J, Tabb LP, Saunders AJ, Marenda DR. Development and characterization of an aged onset model of Alzheimer's disease in Drosophila melanogaster. Experimental Neurology. 261: 772-81. PMID 25173219 DOI: 10.1016/j.expneurol.2014.08.021  0.76
2014 Mhatre SD, Satyasi V, Killen M, Paddock BE, Moir RD, Saunders AJ, Marenda DR. Synaptic abnormalities in a Drosophila model of Alzheimer's disease. Disease Models & Mechanisms. 7: 373-85. PMID 24487408 DOI: 10.1242/dmm.012104  0.76
2013 Reza MA, Mhatre SD, Morrison JC, Utreja S, Saunders AJ, Breen DE, Marenda DR. Automated analysis of courtship suppression learning and memory in Drosophila melanogaster. Fly. 7: 105-11. PMID 23644900 DOI: 10.4161/fly.24110  0.76
2013 Mhatre SD, Paddock BE, Saunders AJ, Marenda DR. Invertebrate models of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 3-16. PMID 22886023 DOI: 10.3233/JAD-2012-121204  0.76
2012 Hooli BV, Mohapatra G, Mattheisen M, Parrado AR, Roehr JT, Shen Y, Gusella JF, Moir R, Saunders AJ, Lange C, Tanzi RE, Bertram L. Role of common and rare APP DNA sequence variants in Alzheimer disease. Neurology. 78: 1250-7. PMID 22491860 DOI: 10.1212/WNL.0b013e3182515972  0.76
2012 Distefano GM, Gangemi AJ, Khandelwal PJ, Saunders AJ, Marenda DR. Drosophila lilliputian is required for proneural gene expression in retinal development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 241: 553-62. PMID 22275119 DOI: 10.1002/dvdy.23738  0.76
2012 Ansaloni S, Leung BP, Dubey A, Saunders AJ. Tyrosine kinase receptor B isoforms alter APP and BACE1 endogenous levels independently of BDNF Advances in Alzheimer's Disease. 1: 93-101. DOI: 10.4236/aad.2012.13012  0.6
2012 Reza MA, Marker J, Mhatre S, Saunders A, Marenda D, Breen D. Video analysis algorithms for automated categorization of fly behaviors Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 7432: 229-241. DOI: 10.1007/978-3-642-33191-6_23  0.76
2011 Chakraborty R, Vepuri V, Mhatre SD, Paddock BE, Miller S, Michelson SJ, Delvadia R, Desai A, Vinokur M, Melicharek DJ, Utreja S, Khandelwal P, Ansaloni S, Goldstein LE, Moir RD, ... ... Saunders AJ, et al. Characterization of a Drosophila Alzheimer's disease model: pharmacological rescue of cognitive defects. Plos One. 6: e20799. PMID 21673973 DOI: 10.1371/journal.pone.0020799  0.76
2011 Ansaloni S, Leung BP, Sebastian NP, Samudralwar R, Gadaleta M, Saunders AJ. TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains. International Journal of Alzheimer's Disease. 2011: 729382. PMID 21423675 DOI: 10.4061/2011/729382  0.76
2010 Ansaloni S, Lelkes N, Snyder J, Epstein C, Dubey A, Saunders AJ. A streamlined sub-cloning procedure to transfer shRNA from a pSM2 vector to a pGIPZ lentiviral vector. Journal of Rnai and Gene Silencing : An International Journal of Rna and Gene Targeting Research. 6: 411-5. PMID 21139985  0.6
2009 Jain S, Zhang X, Khandelwal PJ, Saunders AJ, Cummings BS, Oelkers P. Characterization of human lysophospholipid acyltransferase 3. Journal of Lipid Research. 50: 1563-70. PMID 19351971 DOI: 10.1194/jlr.M800398-JLR200  0.76
2008 Patel N, Hoang D, Miller N, Ansaloni S, Huang Q, Rogers JT, Lee JC, Saunders AJ. MicroRNAs can regulate human APP levels. Molecular Neurodegeneration. 3: 10. PMID 18684319 DOI: 10.1186/1750-1326-3-10  0.76
2008 Saunders A, Khandelwal P, Zhang C, Lee J, Marenda DR. IC-P1-053: Genetic screen to identify APP metabolism regulators Alzheimer's & Dementia. 4: T29-T29. DOI: 10.1016/j.jalz.2008.05.063  0.76
2007 Zhang C, Khandelwal PJ, Chakraborty R, Cuellar TL, Sarangi S, Patel SA, Cosentino CP, O'Connor M, Lee JC, Tanzi RE, Saunders AJ. An AICD-based functional screen to identify APP metabolism regulators. Molecular Neurodegeneration. 2: 15. PMID 17718916 DOI: 10.1186/1750-1326-2-15  0.76
2007 Gumireddy K, Sun F, Klein-Szanto AJ, Gibbins JM, Gimotty PA, Saunders AJ, Schultz PG, Huang Q. In vivo selection for metastasis promoting genes in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 6696-701. PMID 17420453 DOI: 10.1073/pnas.0701145104  0.76
2006 McCall SJ, Nassar R, Malouf NN, Saunders AJ, Oakeley AE, Henderson PM, Solaro RJ, Pielak GJ, Alexander KA, Anderson PA. Development and cardiac contractility: cardiac troponin T isoforms and cytosolic calcium in rabbit. Pediatric Research. 60: 276-81. PMID 16857772 DOI: 10.1203/01.pdr.0000233004.95404.1f  0.76
2006 Cocklin S, Jost M, Robertson NM, Weeks SD, Weber HW, Young E, Seal S, Zhang C, Mosser E, Loll PJ, Saunders AJ, Rest RF, Chaiken IM. Real-time monitoring of the membrane-binding and insertion properties of the cholesterol-dependent cytolysin anthrolysin O from Bacillus anthracis. Journal of Molecular Recognition : Jmr. 19: 354-62. PMID 16775845 DOI: 10.1002/jmr.784  0.76
2004 Chylack LT, Fu L, Mancini R, Martin-Rehrmann MD, Saunders AJ, Konopka G, Tian D, Hedley-Whyte ET, Folkerth RD, Goldstein LE. Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain. Experimental Eye Research. 79: 941-8. PMID 15642333 DOI: 10.1016/j.exer.2004.08.022  0.76
2004 Cuellar TL, Cosentino CP, Saunders AJ. P1-279 Investigating the role of the insulin signaling pathway on APP processing Neurobiology of Aging. 25: S175. DOI: 10.1016/S0197-4580(04)80592-X  0.44
2003 Saunders AJ, Tanzi RE. Welcome to the complex disease world. Alpha2-macroglobulin and Alzheimer's disease. Experimental Neurology. 184: 50-3. PMID 14637079 DOI: 10.1016/j.expneurol.2003.09.004  0.76
2003 Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, et al. Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Human Molecular Genetics. 12: 2765-76. PMID 12966032 DOI: 10.1093/hmg/ddg310  0.76
2003 Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. The Journal of Biological Chemistry. 278: 19777-83. PMID 12649271 DOI: 10.1074/jbc.M300466200  0.76
2003 Engstrom G, Rajagukguk R, Saunders AJ, Patel CN, Rajagukguk S, Merbitz-Zahradnik T, Xiao K, Pielak GJ, Trumpower B, Yu CA, Yu L, Durham B, Millett F. Design of a ruthenium-labeled cytochrome c derivative to study electron transfer with the cytochrome bc1 complex. Biochemistry. 42: 2816-24. PMID 12627947 DOI: 10.1021/bi027213g  0.76
2003 Blacker D, Bertram L, Saunders AJ, Moscarillo TJ, Albert MS, Wiener H, Perry RT, Collins JS, Harrell LE, Go RC, Mahoney A, Beaty T, Fallin MD, Avramopoulos D, Chase GA, et al. Results of a high-resolution genome screen of 437 Alzheimer's disease families. Human Molecular Genetics. 12: 23-32. PMID 12490529 DOI: 10.1093/hmg/ddg007  0.76
2001 Davis-Searles PR, Saunders AJ, Erie DA, Winzor DJ, Pielak GJ. Interpreting the effects of small uncharged solutes on protein-folding equilibria. Annual Review of Biophysics and Biomolecular Structure. 30: 271-306. PMID 11340061 DOI: 10.1146/annurev.biophys.30.1.271  0.76
2000 Yoo AS, Cheng I, Chung S, Grenfell TZ, Lee H, Pack-Chung E, Handler M, Shen J, Xia W, Tesco G, Saunders AJ, Ding K, Frosch MP, Tanzi RE, Kim TW. Presenilin-mediated modulation of capacitative calcium entry. Neuron. 27: 561-72. PMID 11055438 DOI: 10.1016/S0896-6273(00)00066-0  0.76
2000 Goldstein LE, Leopold MC, Huang X, Atwood CS, Saunders AJ, Hartshorn M, Lim JT, Faget KY, Muffat JA, Scarpa RC, Chylack LT, Bowden EF, Tanzi RE, Bush AI. 3-Hydroxykynurenine and 3-hydroxyanthranilic acid generate hydrogen peroxide and promote alpha-crystallin cross-linking by metal ion reduction. Biochemistry. 39: 7266-75. PMID 10852726 DOI: 10.1021/bi992997s  0.76
2000 Saunders AJ, Davis-Searles PR, Allen DL, Pielak GJ, Erie DA. Osmolyte-induced changes in protein conformational equilibria. Biopolymers. 53: 293-307. PMID 10685050 DOI: 10.1002/(SICI)1097-0282(20000405)53:4<293::AID-BIP2>3.0.CO;2-T  0.76
1999 Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. The Journal of Biological Chemistry. 274: 37111-6. PMID 10601271 DOI: 10.1074/jbc.274.52.37111  0.76
1999 Hostetter DR, Weatherly GT, Beasley JR, Bortone K, Cohen DS, Finger SA, Hardwidge P, Kakouras DS, Saunders AJ, Trojak SK, Waldner JC, Pielak GJ. Partially formed native tertiary interactions in the A-state of cytochrome c. Journal of Molecular Biology. 289: 639-44. PMID 10356334 DOI: 10.1006/jmbi.1999.2764  0.76
1998 Davis-Searles PR, Morar AS, Saunders AJ, Erie DA, Pielak GJ. Sugar-induced molten-globule model. Biochemistry. 37: 17048-53. PMID 9836600 DOI: 10.1021/bi981364v  0.76
1996 Wang K, Mei H, Geren L, Miller MA, Saunders A, Wang X, Waldner JL, Pielak GJ, Durham B, Millett F. Design of a ruthenium-cytochrome c derivative to measure electron transfer to the radical cation and oxyferryl heme in cytochrome c peroxidase. Biochemistry. 35: 15107-19. PMID 8942678 DOI: 10.1021/bi9611117  0.76
1996 Pappa HS, Tajbaksh S, Saunders AJ, Pielak GJ, Poulos TL. Probing the cytochrome c peroxidase-cytochrome c electron transfer reaction using site specific cross-linking. Biochemistry. 35: 4837-45. PMID 8664274 DOI: 10.1021/bi952935b  0.76
1996 Betz SF, Marmorino JL, Saunders AJ, Doyle DF, Young GB, Pielak GJ. Unusual effects of an engineered disulfide on global and local protein stability. Biochemistry. 35: 7422-8. PMID 8652519 DOI: 10.1021/bi9528558  0.76
1996 Miller MA, Geren L, Han GW, Saunders A, Beasley J, Pielak GJ, Durham B, Millett F, Kraut J. Identifying the physiological electron transfer site of cytochrome c peroxidase by structure-based engineering. Biochemistry. 35: 667-73. PMID 8547245 DOI: 10.1021/bi952557a  0.76
1995 Pielak GJ, Auld DS, Beasley JR, Betz SF, Cohen DS, Doyle DF, Finger SA, Fredericks ZL, Hilgen-Willis S, Saunders AJ. Protein thermal denaturation, side-chain models, and evolution: amino acid substitutions at a conserved helix-helix interface. Biochemistry. 34: 3268-76. PMID 7880822 DOI: 10.1021/bi00010a017  0.76
1995 Geren LM, Beasley JR, Fine BR, Saunders AJ, Hibdon S, Pielak GJ, Durham B, Millett F. Design of a ruthenium-cytochrome c derivative to measure electron transfer to the initial acceptor in cytochrome c oxidase. The Journal of Biological Chemistry. 270: 2466-72. PMID 7852307 DOI: 10.1074/jbc.270.6.2466  0.76
1993 Willie A, McLean M, Liu RQ, Hilgen-Willis S, Saunders AJ, Pielak GJ, Sligar SG, Durham B, Millett F. Intracomplex electron transfer between ruthenium-65-cytochrome b5 and position-82 variants of yeast iso-1-cytochrome c. Biochemistry. 32: 7519-25. PMID 8393343 DOI: 10.1021/bi00080a025  0.76
1993 Saunders AJ, Young GB, Pielak GJ. Polarity of disulfide bonds. Protein Science : a Publication of the Protein Society. 2: 1183-4. PMID 8358301 DOI: 10.1002/pro.5560020713  0.76
1993 Auld DS, Young GB, Saunders AJ, Doyle DF, Betz SF, Pielak GJ. Probing weakly polar interactions in cytochrome c. Protein Science : a Publication of the Protein Society. 2: 2187-97. PMID 8298464 DOI: 10.1002/pro.5560021218  0.76
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