| Year |
Citation |
Score |
| 2023 |
Tipton AE, Cruz Del Angel Y, Hixson K, Carlsen J, Strode D, Busquet N, Mesches MH, Gonzalez MI, Napoli E, Russek SJ, Brooks-Kayal AR. Selective neuronal knockout of STAT3 function inhibits epilepsy progression, improves cognition, and restores dysregulated gene networks in a temporal lobe epilepsy model. Annals of Neurology. PMID 36935347 DOI: 10.1002/ana.26644 |
0.331 |
|
| 2021 |
Cruz Del Angel Y, Orfila JE, Herson PS, Brooks-Kayal A, González MI. Down-regulation of AMPA receptors and long-term potentiation during early epileptogenesis. Epilepsy & Behavior : E&B. 124: 108320. PMID 34592633 DOI: 10.1016/j.yebeh.2021.108320 |
0.382 |
|
| 2021 |
Ahmed MM, Carrel AJ, Cruz Del Angel Y, Carlsen J, Thomas AX, González MI, Gardiner KJ, Brooks-Kayal A. Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy. Frontiers in Neurology. 12: 654606. PMID 34122302 DOI: 10.3389/fneur.2021.654606 |
0.392 |
|
| 2019 |
Hixson KM, Cogswell M, Brooks-Kayal AR, Russek SJ. Evidence for a non-canonical JAK/STAT signaling pathway in the synthesis of the brain's major ion channels and neurotransmitter receptors. Bmc Genomics. 20: 677. PMID 31455240 DOI: 10.1186/S12864-019-6033-2 |
0.366 |
|
| 2019 |
Carvill GL, Dulla CG, Lowenstein DH, Brooks-Kayal AR. The path from scientific discovery to cures for epilepsy. Neuropharmacology. 107702. PMID 31301334 DOI: 10.1016/J.Neuropharm.2019.107702 |
0.389 |
|
| 2019 |
Isom LL, Wilcox KS, Brooks-Kayal A. Mechanisms of Epilepsy and Neuronal Synchronization Gordon Research Conference Power Hour Summary. Epilepsy Currents. 1535759719858342. PMID 31282199 DOI: 10.1177/1535759719858342 |
0.334 |
|
| 2019 |
Demarest ST, Brooks-Kayal A. From molecules to medicines: the dawn of targeted therapies for genetic epilepsies. Nature Reviews. Neurology. 14: 735-745. PMID 30448857 DOI: 10.1038/S41582-018-0099-3 |
0.37 |
|
| 2018 |
Li Z, Cogswell M, Hixson K, Brooks-Kayal AR, Russek SJ. Nuclear Respiratory Factor 1 (NRF-1) Controls the Activity Dependent Transcription of the GABA-A Receptor Beta 1 Subunit Gene in Neurons. Frontiers in Molecular Neuroscience. 11: 285. PMID 30186109 DOI: 10.3389/Fnmol.2018.00285 |
0.451 |
|
| 2017 |
Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, et al. Commonalities in epileptogenic processes from different acute brain insults: Do they translate? Epilepsia. PMID 29247482 DOI: 10.1111/Epi.13965 |
0.438 |
|
| 2017 |
Simonato M, Iyengar S, Brooks-Kayal A, Collins S, Depaulis A, Howells DW, Jensen F, Liao J, Macleod MR, Patel M, Potschka H, Walker M, Whittemore V, Sena ES. Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 58: 68-77. PMID 29105071 DOI: 10.1111/Epi.13908 |
0.37 |
|
| 2016 |
Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. PMID 28035782 DOI: 10.1111/Epi.13652 |
0.375 |
|
| 2015 |
Raible DJ, Frey LC, Del Angel YC, Carlsen J, Hund D, Russek SJ, Smith B, Brooks-Kayal AR. JAK/STAT pathway regulation of GABAA Receptor expression after differing severities of experimental TBI. Experimental Neurology. PMID 26172316 DOI: 10.1016/J.Expneurol.2015.07.001 |
0.486 |
|
| 2015 |
González MI, Grabenstatter HL, Cea-Del Rio CA, Cruz Del Angel Y, Carlsen J, Laoprasert RP, White AM, Huntsman MM, Brooks-Kayal A. Seizure-related regulation of GABAA receptors in spontaneously epileptic rats. Neurobiology of Disease. 77: 246-56. PMID 25769812 DOI: 10.1016/J.Nbd.2015.03.001 |
0.461 |
|
| 2014 |
Grabenstatter HL, Cogswell M, Cruz Del Angel Y, Carlsen J, Gonzalez MI, Raol YH, Russek SJ, Brooks-Kayal AR. Effect of spontaneous seizures on GABAA receptor α4 subunit expression in an animal model of temporal lobe epilepsy. Epilepsia. 55: 1826-33. PMID 25223733 DOI: 10.1111/Epi.12771 |
0.572 |
|
| 2014 |
Simonato M, Brooks-Kayal AR, Engel J, Galanopoulou AS, Jensen FE, Moshé SL, O'Brien TJ, Pitkanen A, Wilcox KS, French JA. The challenge and promise of anti-epileptic therapy development in animal models. The Lancet. Neurology. 13: 949-60. PMID 25127174 DOI: 10.1016/S1474-4422(14)70076-6 |
0.389 |
|
| 2014 |
Scharfman HE, Brooks-Kayal AR. Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Advances in Experimental Medicine and Biology. 813: 133-50. PMID 25012373 DOI: 10.1007/978-94-017-8914-1_11 |
0.57 |
|
| 2014 |
Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. Journal of Neuroscience Research. 92: 1307-18. PMID 24801281 DOI: 10.1002/Jnr.23402 |
0.469 |
|
| 2014 |
Grabenstatter HL, Del Angel YC, Carlsen J, Wempe MF, White AM, Cogswell M, Russek SJ, Brooks-Kayal AR. The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy. Neurobiology of Disease. 62: 73-85. PMID 24051278 DOI: 10.1016/J.Nbd.2013.09.003 |
0.471 |
|
| 2013 |
Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, McArthur DL, Wu JY, Leung M, Buxey F, Szeliga C, Van Hirtum-Das M, Sankar R, Brooks-Kayal A, Giza CC. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia. 54: 1780-8. PMID 24032982 DOI: 10.1111/Epi.12369 |
0.369 |
|
| 2013 |
Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 54: 44-60. PMID 23909853 DOI: 10.1111/Epi.12298 |
0.398 |
|
| 2013 |
González MI, Cruz Del Angel Y, Brooks-Kayal A. Down-regulation of gephyrin and GABAA receptor subunits during epileptogenesis in the CA1 region of hippocampus. Epilepsia. 54: 616-24. PMID 23294024 DOI: 10.1111/Epi.12063 |
0.572 |
|
| 2012 |
Grabenstatter HL, Russek SJ, Brooks-Kayal AR. Molecular pathways controlling inhibitory receptor expression. Epilepsia. 53: 71-8. PMID 23216580 DOI: 10.1111/Epi.12036 |
0.607 |
|
| 2012 |
Raible DJ, Frey LC, Cruz Del Angel Y, Russek SJ, Brooks-Kayal AR. GABA(A) receptor regulation after experimental traumatic brain injury. Journal of Neurotrauma. 29: 2548-54. PMID 22827467 DOI: 10.1089/Neu.2012.2483 |
0.525 |
|
| 2012 |
Chapman KE, Raol YH, Brooks-Kayal A. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. The European Journal of Neuroscience. 35: 1857-65. PMID 22708596 DOI: 10.1111/J.1460-9568.2012.08140.X |
0.344 |
|
| 2012 |
Raol YH, Brooks-Kayal AR. Experimental models of seizures and epilepsies. Progress in Molecular Biology and Translational Science. 105: 57-82. PMID 22137429 DOI: 10.1016/B978-0-12-394596-9.00003-2 |
0.45 |
|
| 2012 |
Kim JH, Roberts DS, Hu Y, Lau GC, Brooks-Kayal AR, Farb DH, Russek SJ. Brain-derived neurotrophic factor uses CREB and Egr3 to regulate NMDA receptor levels in cortical neurons. Journal of Neurochemistry. 120: 210-9. PMID 22035109 DOI: 10.1111/J.1471-4159.2011.07555.X |
0.425 |
|
| 2011 |
Baram TZ, Jensen FE, Brooks-Kayal A. Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Currents / American Epilepsy Society. 11: 21-6. PMID 21461261 DOI: 10.5698/1535-7511-11.1.21 |
0.447 |
|
| 2011 |
González MI, Brooks-Kayal A. Altered GABA(A) receptor expression during epileptogenesis. Neuroscience Letters. 497: 218-22. PMID 21376781 DOI: 10.1016/J.Neulet.2011.02.052 |
0.583 |
|
| 2011 |
Brooks-Kayal A. Molecular mechanisms of cognitive and behavioral comorbidities of epilepsy in children. Epilepsia. 13-20. PMID 21214535 DOI: 10.1111/J.1528-1167.2010.02906.X |
0.371 |
|
| 2010 |
Brooks-Kayal A. Epilepsy and autism spectrum disorders: are there common developmental mechanisms? Brain & Development. 32: 731-8. PMID 20570072 DOI: 10.1016/J.Braindev.2010.04.010 |
0.367 |
|
| 2010 |
McRae PA, Baranov E, Sarode S, Brooks-Kayal AR, Porter BE. Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure. Neurobiology of Disease. 39: 439-48. PMID 20493259 DOI: 10.1016/J.Nbd.2010.05.015 |
0.454 |
|
| 2010 |
Brooks-Kayal AR, Russek SJ. Regulation of GABAA receptor gene expression and epilepsy Epilepsia. 51: 51. DOI: 10.1111/J.1528-1167.2010.02837.X |
0.575 |
|
| 2009 |
Marsh E, Fulp C, Gomez E, Nasrallah I, Minarcik J, Sudi J, Christian SL, Mancini G, Labosky P, Dobyns W, Brooks-Kayal A, Golden JA. Targeted loss of Arx results in a developmental epilepsy mouse model and recapitulates the human phenotype in heterozygous females. Brain : a Journal of Neurology. 132: 1563-76. PMID 19439424 DOI: 10.1093/Brain/Awp107 |
0.383 |
|
| 2009 |
Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. Curing epilepsy: progress and future directions. Epilepsy & Behavior : E&B. 14: 438-45. PMID 19341977 DOI: 10.1016/J.Yebeh.2009.02.036 |
0.414 |
|
| 2009 |
Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Annals of Neurology. 65: 326-36. PMID 19334075 DOI: 10.1002/ana.21593 |
0.334 |
|
| 2009 |
Brooks-Kayal AR, Raol YH, Russek SJ. Alteration of epileptogenesis genes. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 312-8. PMID 19332325 DOI: 10.1016/J.Nurt.2009.01.019 |
0.607 |
|
| 2008 |
Lund IV, Hu Y, Raol YH, Benham RS, Faris R, Russek SJ, Brooks-Kayal AR. BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway. Science Signaling. 1: ra9. PMID 18922788 DOI: 10.1126/Scisignal.1162396 |
0.792 |
|
| 2008 |
Hu Y, Lund IV, Gravielle MC, Farb DH, Brooks-Kayal AR, Russek SJ. Surface expression of GABAA receptors is transcriptionally controlled by the interplay of cAMP-response element-binding protein and its binding partner inducible cAMP early repressor. The Journal of Biological Chemistry. 283: 9328-40. PMID 18180303 DOI: 10.1074/Jbc.M705110200 |
0.795 |
|
| 2008 |
Marsh ED, Minarcik J, Campbell K, Brooks-Kayal AR, Golden JA. FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Developmental Neurobiology. 68: 434-45. PMID 18172891 DOI: 10.1002/Dneu.20602 |
0.368 |
|
| 2006 |
Marsh ED, Brooks-Kayal AR, Porter BE. Seizures and antiepileptic drugs: does exposure alter normal brain development? Epilepsia. 47: 1999-2010. PMID 17201696 DOI: 10.1111/J.1528-1167.2006.00894.X |
0.401 |
|
| 2006 |
Raol YH, Lund IV, Bandyopadhyay S, Zhang G, Roberts DS, Wolfe JH, Russek SJ, Brooks-Kayal AR. Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11342-6. PMID 17079662 DOI: 10.1523/Jneurosci.3329-06.2006 |
0.8 |
|
| 2006 |
Raol YH, Zhang G, Lund IV, Porter BE, Maronski MA, Brooks-Kayal AR. Increased GABA(A)-receptor alpha1-subunit expression in hippocampal dentate gyrus after early-life status epilepticus. Epilepsia. 47: 1665-73. PMID 17054689 DOI: 10.1111/J.1528-1167.2006.00640.X |
0.797 |
|
| 2006 |
Roberts DS, Hu Y, Lund IV, Brooks-Kayal AR, Russek SJ. Brain-derived neurotrophic factor (BDNF)-induced synthesis of early growth response factor 3 (Egr3) controls the levels of type A GABA receptor alpha 4 subunits in hippocampal neurons. The Journal of Biological Chemistry. 281: 29431-5. PMID 16901909 DOI: 10.1074/Jbc.C600167200 |
0.808 |
|
| 2006 |
Porter BE, Cui XN, Brooks-Kayal AR. Status epilepticus differentially alters AMPA and kainate receptor subunit expression in mature and immature dentate granule neurons. The European Journal of Neuroscience. 23: 2857-63. PMID 16819974 DOI: 10.1111/j.1460-9568.2006.04839.x |
0.424 |
|
| 2006 |
Frye CA, Rhodes ME, Raol YH, Brooks-Kayal AR. Early postnatal stimulation alters pregnane neurosteroids in the hippocampus. Psychopharmacology. 186: 343-50. PMID 16491430 DOI: 10.1007/S00213-005-0253-7 |
0.441 |
|
| 2005 |
Brooks-Kayal AR. Rearranging receptors. Epilepsia. 46: 29-38. PMID 16201993 DOI: 10.1111/j.1528-1167.2005.00301.x |
0.403 |
|
| 2005 |
Roberts DS, Raol YH, Bandyopadhyay S, Lund IV, Budreck EC, Passini MA, Passini MJ, Wolfe JH, Brooks-Kayal AR, Russek SJ. Egr3 stimulation of GABRA4 promoter activity as a mechanism for seizure-induced up-regulation of GABA(A) receptor alpha4 subunit expression. Proceedings of the National Academy of Sciences of the United States of America. 102: 11894-9. PMID 16091474 DOI: 10.1073/Pnas.0501434102 |
0.808 |
|
| 2005 |
Raol YH, Zhang G, Budreck EC, Brooks-Kayal AR. Long-term effects of diazepam and phenobarbital treatment during development on GABA receptors, transporters and glutamic acid decarboxylase. Neuroscience. 132: 399-407. PMID 15802192 DOI: 10.1016/J.Neuroscience.2005.01.005 |
0.592 |
|
| 2005 |
Raizen DM, Brooks-Kayal A, Steinkrauss L, Tennekoon GI, Stanley CA, Kelly A. Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations. The Journal of Pediatrics. 146: 388-94. PMID 15756227 DOI: 10.1016/J.Jpeds.2004.10.040 |
0.319 |
|
| 2005 |
Porter BE, Zhang G, Celix J, Hsu FC, Raol YH, Telfeian A, Gallagher PR, Coulter DA, Brooks-Kayal AR. Heterogeneous GABAA receptor subunit expression in pediatric epilepsy patients. Neurobiology of Disease. 18: 484-91. PMID 15755675 DOI: 10.1016/J.Nbd.2004.12.010 |
0.559 |
|
| 2004 |
Kao A, Mariani J, McDonald-McGinn DM, Maisenbacher MK, Brooks-Kayal AR, Zackai EH, Lynch DR. Increased prevalence of unprovoked seizures in patients with a 22q11.2 deletion. American Journal of Medical Genetics. Part A. 129: 29-34. PMID 15266612 DOI: 10.1002/Ajmg.A.30133 |
0.388 |
|
| 2004 |
Zhang G, Raol YH, Hsu FC, Coulter DA, Brooks-Kayal AR. Effects of status epilepticus on hippocampal GABAA receptors are age-dependent. Neuroscience. 125: 299-303. PMID 15062973 DOI: 10.1016/J.Neuroscience.2004.01.040 |
0.586 |
|
| 2004 |
Porter BE, Maronski M, Brooks-Kayal AR. Fate of newborn dentate granule cells after early life status epilepticus. Epilepsia. 45: 13-9. PMID 14692902 DOI: 10.1111/J.0013-9580.2004.23903.X |
0.342 |
|
| 2004 |
Zhang G, Raol YS, Hsu FC, Brooks-Kayal AR. Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. Journal of Neurochemistry. 88: 91-101. PMID 14675153 DOI: 10.1046/J.1471-4159.2003.02124.X |
0.521 |
|
| 2003 |
Hsu FC, Zhang GJ, Raol YS, Valentino RJ, Coulter DA, Brooks-Kayal AR. Repeated neonatal handling with maternal separation permanently alters hippocampal GABAA receptors and behavioral stress responses. Proceedings of the National Academy of Sciences of the United States of America. 100: 12213-8. PMID 14530409 DOI: 10.1073/Pnas.2131679100 |
0.392 |
|
| 2003 |
Raol YS, Budreck EC, Brooks-Kayal AR. Epilepsy after early-life seizures can be independent of hippocampal injury. Annals of Neurology. 53: 503-11. PMID 12666118 DOI: 10.1002/ana.10490 |
0.371 |
|
| 2002 |
Crino PB, Jin H, Shumate MD, Robinson MB, Coulter DA, Brooks-Kayal AR. Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia. 43: 211-8. PMID 11906504 DOI: 10.1046/J.1528-1157.2002.35001.X |
0.469 |
|
| 2002 |
Porter BE, Brooks-Kayal A, Golden JA. Disorders of cortical development and epilepsy. Archives of Neurology. 59: 361-5. PMID 11890838 DOI: 10.1001/Archneur.59.3.361 |
0.39 |
|
| 2001 |
Raol YH, Lynch DR, Brooks-Kayal AR. Role of excitatory amino acids in developmental epilepsies Mental Retardation and Developmental Disabilities Research Reviews. 7: 254-260. PMID 11754519 DOI: 10.1002/Mrdd.1035 |
0.471 |
|
| 2001 |
Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Kelly ME, Coulter DA. gamma-Aminobutyric acid(A) receptor subunit expression predicts functional changes in hippocampal dentate granule cells during postnatal development. Journal of Neurochemistry. 77: 1266-78. PMID 11389177 DOI: 10.1046/J.1471-4159.2001.00329.X |
0.6 |
|
| 2000 |
Bergqvist AG, Chee CM, Lutchka LM, Brooks-Kayal AR. Treatment of acquired epileptic aphasia with the ketogenic diet. Journal of Child Neurology. 14: 696-701. PMID 10593544 DOI: 10.1177/088307389901401102 |
0.307 |
|
| 1999 |
Brooks-Kayal AR, Shumate MD, Jin H, Lin DD, Rikhter TY, Holloway KL, Coulter DA. Human Neuronal γ-Aminobutyric AcidAReceptors: Coordinated Subunit mRNA Expression and Functional Correlates in Individual Dentate Granule Cells The Journal of Neuroscience. 19: 8312-8318. DOI: 10.1523/Jneurosci.19-19-08312.1999 |
0.439 |
|
| 1999 |
Brooks-Kayal A, Shumate M, Jin H, Rikhter T, Coulter D. Erratum: Selective changes in single cell GABAA receptor expression and functionin temporal lobe epilepsy Nature Medicine. 5: 590-590. DOI: 10.1038/8477 |
0.349 |
|
| 1998 |
Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nature Medicine. 4: 1166-72. PMID 9771750 DOI: 10.1038/2661 |
0.608 |
|
| 1998 |
Brooks-Kayal AR, Munir M, Jin H, Robinson MB. The glutamate transporter, GLT-1, is expressed in cultured hippocampal neurons. Neurochemistry International. 33: 95-100. PMID 9761452 DOI: 10.1016/S0197-0186(98)00018-7 |
0.353 |
|
| 1998 |
Brooks-Kayal AR, Jin H, Price M, Dichter MA. Developmental expression of GABA(A) receptor subunit mRNAs in individual hippocampal neurons in vitro and in vivo. Journal of Neurochemistry. 70: 1017-28. PMID 9489721 DOI: 10.1046/J.1471-4159.1998.70031017.X |
0.496 |
|
| 1997 |
Amin J, Brooks-Kayal A, Weiss DS. Two tyrosine residues on the alpha subunit are crucial for benzodiazepine binding and allosteric modulation of gamma-aminobutyric acidA receptors. Molecular Pharmacology. 51: 833-41. PMID 9145922 DOI: 10.1124/Mol.51.5.833 |
0.541 |
|
| 1993 |
Brooks-Kayal AR, Pritchett DB. Developmental changes in human gamma-aminobutyric acidA receptor subunit composition. Annals of Neurology. 34: 687-93. PMID 7694542 DOI: 10.1002/ana.410340511 |
0.415 |
|
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