Year |
Citation |
Score |
2021 |
Azhar N, Namas RA, Almahmoud K, Zaaqoq A, Malak OA, Barclay D, Yin J, El-Dehaibi F, Abboud A, Simmons RL, Zamora R, Billiar TR, Vodovotz Y. A putative "chemokine switch" that regulates systemic acute inflammation in humans. Scientific Reports. 11: 9703. PMID 33958628 DOI: 10.1038/s41598-021-88936-8 |
0.78 |
|
2020 |
Schimunek L, Lindberg H, Cohen M, Namas RA, Mi Q, Yin J, Barclay D, El-Dehaibi F, Abboud A, Zamora R, Billiar TR, Vodovotz Y. Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes. Frontiers in Immunology. 11: 589304. PMID 33537029 DOI: 10.3389/fimmu.2020.589304 |
0.316 |
|
2020 |
Yazdani HO, Kaltenmeier C, Morder K, Moon J, Traczek M, Loughran P, Zamora R, Vodovotz Y, Li F, Wang JH, Geller DA, Simmons RL, Tohme S. Exercise training decreases hepatic injury via changes in immune response to liver ischemia/reperfusion in mice. Hepatology (Baltimore, Md.). PMID 32924145 DOI: 10.1002/Hep.31552 |
0.312 |
|
2020 |
Sachdev U, Vodovotz L, Barclay D, Lin Y, Zamora R, Bitner J, Avgerinos E, Vodovotz Y. Infrared Thermography Confirms Inflammatory Differences in Refluxing Versus Competent Lower Extremity Veins Journal of Vascular Surgery. Venous and Lymphatic Disorders. 8: 310-311. DOI: 10.1016/J.Jvsv.2019.12.007 |
0.336 |
|
2019 |
Zaaqoq AM, Namas RA, Abdul-Malak O, Almahmoud K, Barclay D, Yin J, Zamora R, Rosengart MR, Billiar TR, Vodovotz Y. Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma. Frontiers in Immunology. 10: 2699. PMID 31824494 DOI: 10.3389/Fimmu.2019.02699 |
0.39 |
|
2019 |
Vodovotz Y, Simmons RL, Barclay D, Yin J, Jefferson BS, Zamora R. Decoding the secreted inflammatory response of primary human hepatocytes to hypoxic stress . Annals of Translational Medicine. 7: 371. PMID 31555685 DOI: 10.21037/Atm.2019.07.09 |
0.314 |
|
2019 |
Billiar IM, Guardado J, Abdul-Malak O, Vodovotz Y, Billiar TR, Namas RA. Elevations in Circulating sST2 Levels Are Associated With In-hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma. The Journal of Surgical Research. 244: 23-33. PMID 31279260 DOI: 10.1016/J.Jss.2019.05.057 |
0.325 |
|
2019 |
Vodovotz Y, An G. Agent-based models of inflammation in translational systems biology: A decade later. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. e1460. PMID 31260168 DOI: 10.1002/Wsbm.1460 |
0.341 |
|
2019 |
Almahmoud K, Abboud A, Namas RA, Zamora R, Sperry J, Peitzman AB, Truitt MS, Gaski GE, McKinley TO, Billiar TR, Vodovotz Y. Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries. Plos One. 14: e0217577. PMID 31163056 DOI: 10.1371/Journal.Pone.0217577 |
0.369 |
|
2019 |
Zamora R, Barclay D, Yin J, Alonso EM, Leonis MA, Mi Q, Billiar TR, Simmons RL, Squires RH, Vodovotz Y. HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen. Scientific Reports. 9: 5971. PMID 30979951 DOI: 10.1038/S41598-019-42564-5 |
0.355 |
|
2019 |
Huang W, Kabbani N, Brannan T, Lin MK, Theiss M, Hamilton J, Ecklund J, Conley YP, Vodovotz Y, Brienza D, Wagner AK, Robbins EA, Sowa GA, Lipsky R. Association of a functional polymorphism in the CHRFAM7A gene with inflammatory response mediators and neuropathic pain after spinal cord injury. Journal of Neurotrauma. PMID 30924722 DOI: 10.1089/Neu.2018.6200 |
0.363 |
|
2019 |
Lamparello AJ, Namas RA, Constantine G, McKinley TO, Elster E, Vodovotz Y, Billiar TR. A conceptual time window-based model for the early stratification of trauma patients. Journal of Internal Medicine. PMID 30623510 DOI: 10.1111/Joim.12874 |
0.326 |
|
2019 |
Tohme S, Yazdani HO, Sud V, Loughran P, Huang H, Zamora R, Simmons RL, Vodovotz Y, Tsung A. Computational Analysis Supports IL-17A as a Central Driver of Neutrophil Extracellular Trap-Mediated Injury in Liver Ischemia Reperfusion. Journal of Immunology (Baltimore, Md. : 1950). 202: 268-277. PMID 30504418 DOI: 10.4049/Jimmunol.1800454 |
0.37 |
|
2019 |
Sachdev U, Barclay D, Zamora R, Vodovotz L, Bitner J, Yin J, Avgerinos E, Vodovotz Y. Primary Chronic Venous Insufficiency Is Distinguished by Attenuated Circulating Inflammatory Mediators and Healing Networks Journal of Vascular Surgery: Venous and Lymphatic Disorders. 7: 287-288. DOI: 10.1016/J.Jvsv.2019.01.007 |
0.331 |
|
2019 |
Lamparello AJ, Zamora R, Namas RA, Vodovotz Y, Billiar TR. Severely Injured Trauma Patients with High Circulating IL-15 Levels Display Worse Outcomes and Distinct Inflammatory Profiles, Suggesting a Role for Natural Killer Cell Activation Journal of the American College of Surgeons. 229: S310. DOI: 10.1016/J.Jamcollsurg.2019.08.675 |
0.345 |
|
2018 |
Day JD, Cockrell C, Namas R, Zamora R, An G, Vodovotz Y. Inflammation and Disease: Modelling and Modulation of the Inflammatory Response to Alleviate Critical Illness. Current Opinion in Systems Biology. 12: 22-29. PMID 30886940 DOI: 10.1016/J.Coisb.2018.08.008 |
0.387 |
|
2018 |
Lamparello AJ, Namas RA, Abdul-Malak O, Vodovotz Y, Billiar TR. Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury. Journal of the American College of Surgeons. PMID 30448299 DOI: 10.1016/J.Jamcollsurg.2018.10.019 |
0.346 |
|
2018 |
Zamora R, Korff S, Mi Q, Barclay D, Schimunek L, Zucca R, Arsiwalla XD, Simmons RL, Verschure P, Billiar TR, Vodovotz Y. A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice. Plos Computational Biology. 14: e1006582. PMID 30399158 DOI: 10.1371/Journal.Pcbi.1006582 |
0.394 |
|
2018 |
Sud V, Abboud A, Tohme S, Vodovotz Y, Simmons RL, Tsung A. IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies. Cytokine. PMID 29954675 DOI: 10.1016/J.Cyto.2018.03.030 |
0.379 |
|
2018 |
McKinley TO, Gaski GE, Vodovotz Y, Corona BT, Billiar TR. Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma. Journal of Orthopaedic Trauma. 32: S1-S6. PMID 29461394 DOI: 10.1097/Bot.0000000000001114 |
0.339 |
|
2018 |
Sachdev U, Vodovotz L, Bitner J, Barclay D, Zamora R, Yin J, Simmons RL, Vodovotz Y. Suppressed networks of inflammatory mediators characterize chronic venous insufficiency. Journal of Vascular Surgery. Venous and Lymphatic Disorders. PMID 29439934 DOI: 10.1016/J.Jvsv.2017.11.009 |
0.342 |
|
2018 |
Lamparello AJ, Namas RA, Vodovotz Y, Billiar TR. Dynamic Bayesian Network Analysis of Inflammation Biomarkers Reveals Age-Related Changes of the Inflammatory Response after Trauma Journal of the American College of Surgeons. 227: S261. DOI: 10.1016/J.Jamcollsurg.2018.07.536 |
0.344 |
|
2017 |
Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R. "Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress. Frontiers in Physiology. 8: 1104. PMID 29312006 DOI: 10.3389/Fphys.2017.01104 |
0.349 |
|
2017 |
Zettel K, Korff S, Zamora R, Morelli AE, Darwiche S, Loughran PA, Elson G, Shang L, Salgado-Pires S, Scott MJ, Vodovotz Y, Billiar TR. Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice. Frontiers in Immunology. 8: 1672. PMID 29234326 DOI: 10.3389/Fimmu.2017.01672 |
0.356 |
|
2017 |
Xu J, Guardado J, Hoffman R, Xu H, Namas R, Vodovotz Y, Xu L, Ramadan M, Brown J, Turnquist HR, Billiar TR. IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model. Plos Medicine. 14: e1002365. PMID 28742815 DOI: 10.1371/Journal.Pmed.1002365 |
0.332 |
|
2017 |
Billiar TR, Vodovotz Y. Time for trauma immunology. Plos Medicine. 14: e1002342. PMID 28700602 DOI: 10.1371/Journal.Pmed.1002342 |
0.312 |
|
2017 |
Krishnan S, Vodovotz Y, Karg PE, Constantine G, Sowa GA, Constantine FJ, Brienza DM. Inflammatory mediators associated with pressure ulcer development in individuals with pneumonia following traumatic spinal cord injury: A pilot study. Archives of Physical Medicine and Rehabilitation. PMID 28130082 DOI: 10.1016/J.Apmr.2016.12.018 |
0.345 |
|
2017 |
Zamora R, Korff S, Barclay D, Yin J, Billiar T, Vodovotz Y. A computational analysis of dynamic, multiorgan inflammation induced by endotoxin in mice Journal of Critical Care. 38: 364. DOI: 10.1016/J.Jcrc.2016.11.017 |
0.317 |
|
2016 |
Vodovotz Y. Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting. Drug Discovery Today. Disease Models. 22: 57-63. PMID 29333176 DOI: 10.1016/J.Ddmod.2017.03.001 |
0.401 |
|
2016 |
Namas RA, Vodovotz Y. From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients. Annals of Translational Medicine. 4: 492. PMID 28149854 DOI: 10.21037/Atm.2016.11.72 |
0.324 |
|
2016 |
Abdul-Malak O, Vodovotz Y, Zaaqoq A, Guardado J, Almahmoud K, Yin J, Zuckerbraun B, Peitzman AB, Sperry J, Billiar TR, Namas RA. Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients. Mediators of Inflammation. 2016: 7950374. PMID 27974867 DOI: 10.1155/2016/7950374 |
0.369 |
|
2016 |
Zamora R, Vodovotz Y, Mi Q, Barclay D, Yin J, Horslen S, Rudnick D, Loomes KM, Squires RH. Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure. Molecular Medicine (Cambridge, Mass.). 22. PMID 27900388 DOI: 10.2119/Molmed.2016.00183 |
0.332 |
|
2016 |
Sadowsky D, Zamora R, Barclay D, Yin J, Fontes P, Vodovotz Y. Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks. Frontiers in Pharmacology. 7: 413. PMID 27867357 DOI: 10.3389/Fphar.2016.00413 |
0.36 |
|
2016 |
Constantine G, Buliga M, Mi Q, Constantine F, Abboud A, Zamora R, Puccio A, Okonkwo D, Vodovotz Y. Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients. Frontiers in Pharmacology. 7: 383. PMID 27847476 DOI: 10.3389/Fphar.2016.00383 |
0.368 |
|
2016 |
Abboud A, Mi Q, Puccio A, Okonkwo D, Buliga M, Constantine G, Vodovotz Y. Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death. Frontiers in Pharmacology. 7: 342. PMID 27729864 DOI: 10.3389/Fphar.2016.00342 |
0.383 |
|
2016 |
Namas RA, Almahmoud K, Mi Q, Ghuma A, Namas R, Zaaqoq A, Zhu X, Abdul-Malak O, Sperry J, Zamora R, Billiar TR, Vodovotz Y. Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients. Journal of Critical Care. 36: 146-153. PMID 27546764 DOI: 10.1016/J.Jcrc.2016.07.002 |
0.373 |
|
2016 |
Abboud A, Namas RA, Ramadan M, Mi Q, Almahmoud K, Abdul-Malak O, Azhar N, Zaaqoq A, Namas R, Barclay DA, Yin J, Sperry J, Peitzman A, Zamora R, Simmons RL, ... ... Vodovotz Y, et al. Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality. Critical Care Medicine. PMID 27513538 DOI: 10.1097/Ccm.0000000000001951 |
0.759 |
|
2016 |
Krishnan S, Karg P, Boninger M, Vodovotz Y, Constantine G, Sowa G, Brienza D. Early detection of pressure ulcer development following traumatic spinal cord injury using inflammatory mediators. Archives of Physical Medicine and Rehabilitation. PMID 26820323 DOI: 10.1016/J.Apmr.2016.01.003 |
0.311 |
|
2015 |
Starzl R, Wolfram D, Zamora R, Jefferson B, Barclay D, Ho C, Gorantla V, Brandacher G, Schneeberger S, Andrew Lee WP, Carbonell J, Vodovotz Y. Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling. Frontiers in Immunology. 6: 587. PMID 26635801 DOI: 10.3389/Fimmu.2015.00587 |
0.347 |
|
2015 |
Namas RA, Mi Q, Namas R, Almahmoud K, Zaaqoq A, Abdul-Malak O, Azhar N, Day J, Abboud A, Zamora R, Billiar T, Vodovotz Y. Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-derived Mediators from Computational Models of Trauma-Induced Inflammation. Antioxidants & Redox Signaling. PMID 26560096 DOI: 10.1089/Ars.2015.6398 |
0.79 |
|
2015 |
Day JD, Metes DM, Vodovotz Y. Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation. Frontiers in Immunology. 6: 484. PMID 26441988 DOI: 10.3389/Fimmu.2015.00484 |
0.377 |
|
2015 |
Ziraldo C, Solovyev A, Allegretti A, Krishnan S, Henzel MK, Sowa GA, Brienza D, An G, Mi Q, Vodovotz Y. A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury. Plos Computational Biology. 11: e1004309. PMID 26111346 DOI: 10.1016/J.Jcrc.2012.10.061 |
0.77 |
|
2015 |
Almahmoud K, Namas RA, Abdul-Malak O, Zaaqoq AM, Zamora R, Zuckerbraun BS, Sperry J, Peitzman AB, Billiar TR, Vodovotz Y. Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma. Shock (Augusta, Ga.). 44: 101-9. PMID 26009819 DOI: 10.1097/Shk.0000000000000395 |
0.343 |
|
2015 |
Vasudeva K, Vodovotz Y, Azhar N, Barclay D, Janjic JM, Pollock JA. In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain. Journal of Neuroimmunology. 283: 43-9. PMID 26004155 DOI: 10.1016/J.Jneuroim.2015.04.012 |
0.764 |
|
2015 |
Brown D, Namas RA, Almahmoud K, Zaaqoq A, Sarkar J, Barclay DA, Yin J, Ghuma A, Abboud A, Constantine G, Nieman G, Zamora R, Chang SC, Billiar TR, Vodovotz Y. Trauma in silico: Individual-specific mathematical models and virtual clinical populations. Science Translational Medicine. 7: 285ra61. PMID 25925680 DOI: 10.1126/Scitranslmed.Aaa3636 |
0.336 |
|
2015 |
Almahmoud K, Namas RA, Zaaqoq AM, Abdul-Malak O, Namas R, Zamora R, Sperry J, Billiar TR, Vodovotz Y. Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans. Critical Care Medicine. 43: 1395-404. PMID 25803650 DOI: 10.1097/Ccm.0000000000000964 |
0.371 |
|
2015 |
Buchholz BM, Shapiro RA, Vodovotz Y, Billiar TR, Sodhi CP, Hackam DJ, Bauer AJ. Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G852-62. PMID 25747352 DOI: 10.1152/Ajpgi.00211.2014 |
0.339 |
|
2015 |
Zolin SJ, Vodovotz Y, Forsythe RM, Rosengart MR, Namas R, Brown JB, Peitzman AP, Billiar TR, Sperry JL. The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury. The Journal of Trauma and Acute Care Surgery. 78: 451-7; discussion 45. PMID 25710413 DOI: 10.1097/Ta.0000000000000550 |
0.321 |
|
2015 |
Wang J, Vodovotz Y, Fan L, Li Y, Liu Z, Namas R, Barclay D, Zamora R, Billiar TR, Wilson MA, Fan J, Jiang Y. Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 250-62. PMID 25342131 DOI: 10.1096/Fj.14-255992 |
0.379 |
|
2015 |
Wolf MT, Vodovotz Y, Tottey S, Brown BN, Badylak SF. Predicting in vivo responses to biomaterials via combined in vitro and in silico analysis. Tissue Engineering. Part C, Methods. 21: 148-59. PMID 24980950 DOI: 10.1089/Ten.Tec.2014.0167 |
0.344 |
|
2015 |
Krishnan S, Karg P, Boninger M, Vodovotz Y, Constantine G, Sowa G, Brienza DM. Early detection of pressure ulcer development following traumatic spinal cord injury using inflammatory mediator concentrations Archives of Physical Medicine and Rehabilitation. 96: e22. DOI: 10.1016/J.Apmr.2015.10.059 |
0.312 |
|
2014 |
Khalifian S, Nicholson Y, Ziraldo C, Starzl R, Schneeberger S, Thomson A, Brandacher G, Vodovotz Y, Raimondi G. Abstract 102: inflammatory mediators modulate alloreactive T cell susceptibility to immune-regulation in reconstructive transplantation. Plastic and Reconstructive Surgery. 133: 117. PMID 25942213 DOI: 10.1097/01.Prs.0000444926.53453.9F |
0.745 |
|
2014 |
Azhar N, Vodovotz Y. Innate immunity in disease: insights from mathematical modeling and analysis. Advances in Experimental Medicine and Biology. 844: 227-43. PMID 25480644 DOI: 10.1007/978-1-4939-2095-2_11 |
0.79 |
|
2014 |
Namas RA, Vodovotz Y, Almahmoud K, Abdul-Malak O, Zaaqoq A, Namas R, Mi Q, Barclay D, Zuckerbraun B, Peitzman AB, Sperry J, Billiar TR. Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans. Annals of Surgery. PMID 25371118 DOI: 10.1097/Sla.0000000000001001 |
0.322 |
|
2014 |
Vodovotz Y. Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience. Interface Focus. 4: 20140004. PMID 25285195 DOI: 10.1098/Rsfs.2014.0004 |
0.411 |
|
2014 |
Sperry JL, Zolin S, Zuckerbraun BS, Vodovotz Y, Namas R, Neal MD, Ferrell RE, Rosengart MR, Peitzman AB, Billiar TR. X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury. Annals of Surgery. 260: 698-703; discussion . PMID 25203887 DOI: 10.1097/Sla.0000000000000918 |
0.308 |
|
2014 |
Dutta-Moscato J, Solovyev A, Mi Q, Nishikawa T, Soto-Gutierrez A, Fox IJ, Vodovotz Y. A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression. Frontiers in Bioengineering and Biotechnology. 2: 18. PMID 25152891 DOI: 10.3389/Fbioe.2014.00018 |
0.357 |
|
2014 |
Zhang Y, Zhang J, Korff S, Ayoob F, Vodovotz Y, Billiar TR. Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock. Shock (Augusta, Ga.). 42: 218-27. PMID 24978887 DOI: 10.1097/Shk.0000000000000211 |
0.375 |
|
2014 |
Wolfram D, Starzl R, Hackl H, Barclay D, Hautz T, Zelger B, Brandacher G, Lee WP, Eberhart N, Vodovotz Y, Pratschke J, Pierer G, Schneeberger S. Insights from computational modeling in inflammation and acute rejection in limb transplantation. Plos One. 9: e99926. PMID 24926998 DOI: 10.1371/Journal.Pone.0099926 |
0.318 |
|
2014 |
Mathew S, Bartels J, Banerjee I, Vodovotz Y. Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses. Journal of Theoretical Biology. 358: 132-48. PMID 24909493 DOI: 10.1016/J.Jtbi.2014.05.036 |
0.402 |
|
2014 |
Aerts JM, Haddad WM, An G, Vodovotz Y. From data patterns to mechanistic models in acute critical illness. Journal of Critical Care. 29: 604-10. PMID 24768566 DOI: 10.1016/J.Jcrc.2014.03.018 |
0.35 |
|
2014 |
Zaaqoq AM, Namas R, Almahmoud K, Azhar N, Mi Q, Zamora R, Brienza DM, Billiar TR, Vodovotz Y. Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Critical Care Medicine. 42: 1487-97. PMID 24584064 DOI: 10.1097/Ccm.0000000000000248 |
0.76 |
|
2014 |
Emr B, Sadowsky D, Azhar N, Gatto LA, An G, Nieman GF, Vodovotz Y. Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies. Shock (Augusta, Ga.). 41: 317-23. PMID 24430553 DOI: 10.1097/Shk.0000000000000121 |
0.784 |
|
2014 |
Huang W, Vodovotz Y, Kusturiss MB, Barclay D, Greenwald K, Boninger ML, Coen PM, Brienza D, Sowa G. Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study. Pm & R : the Journal of Injury, Function, and Rehabilitation. 6: 332-41. PMID 24140737 DOI: 10.1016/J.Pmrj.2013.10.006 |
0.329 |
|
2013 |
Ziraldo C, Mi Q, An G, Vodovotz Y. Computational Modeling of Inflammation and Wound Healing. Advances in Wound Care. 2: 527-537. PMID 24527362 DOI: 10.1089/Wound.2012.0416 |
0.762 |
|
2013 |
Ziraldo C, Vodovotz Y, Namas RA, Almahmoud K, Tapias V, Mi Q, Barclay D, Jefferson BS, Chen G, Billiar TR, Zamora R. Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies. Plos One. 8: e79804. PMID 24312451 DOI: 10.1371/Journal.Pone.0079804 |
0.782 |
|
2013 |
Azhar N, Ziraldo C, Barclay D, Rudnick DA, Squires RH, Vodovotz Y. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure Plos One. 8. PMID 24244295 DOI: 10.1371/Journal.Pone.0078202 |
0.775 |
|
2013 |
Vodovotz Y, Billiar TR. In silico modeling: methods and applications to trauma and sepsis. Critical Care Medicine. 41: 2008-14. PMID 23863232 DOI: 10.1097/Ccm.0B013E31829A6Eb4 |
0.313 |
|
2013 |
Namas RA, Bartels J, Hoffman R, Barclay D, Billiar TR, Zamora R, Vodovotz Y. Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. Plos One. 8: e67419. PMID 23844008 DOI: 10.1371/Journal.Pone.0067419 |
0.351 |
|
2013 |
Price I, Ermentrout B, Zamora R, Wang B, Azhar N, Mi Q, Constantine G, Faeder JR, Luckhart S, Vodovotz Y. In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes. Journal of Theoretical Biology. 334: 173-86. PMID 23764028 DOI: 10.1016/J.Jtbi.2013.05.028 |
0.736 |
|
2013 |
Solovyev A, Mi Q, Tzen YT, Brienza D, Vodovotz Y. Hybrid equation/agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury. Plos Computational Biology. 9: e1003070. PMID 23696726 DOI: 10.1371/Journal.Pcbi.1003070 |
0.311 |
|
2013 |
Christley S, Emr B, Ghosh A, Satalin J, Gatto L, Vodovotz Y, Nieman GF, An G. Bayesian inference of the lung alveolar spatial model for the identification of alveolar mechanics associated with acute respiratory distress syndrome. Physical Biology. 10: 036008. PMID 23598859 DOI: 10.1088/1478-3975/10/3/036008 |
0.309 |
|
2013 |
Hoque R, Vodovotz Y, Mehal W. Therapeutic strategies in inflammasome mediated diseases of the liver. Journal of Hepatology. 58: 1047-52. PMID 23266490 DOI: 10.1016/J.Jhep.2012.12.017 |
0.37 |
|
2013 |
Arciero J, Bard Ermentrout G, Siggers R, Afrazi A, Hackam D, Vodovotz Y, Rubin J. Modeling the interactions of bacteria and Toll-like receptor-mediated inflammation in necrotizing enterocolitis Journal of Theoretical Biology. 321: 83-99. PMID 23238281 DOI: 10.1016/J.Jtbi.2012.12.002 |
0.352 |
|
2013 |
Barber J, Tronzo M, Harold Horvat C, Clermont G, Upperman J, Vodovotz Y, Yotov I. A three-dimensional mathematical and computational model of necrotizing enterocolitis. Journal of Theoretical Biology. 322: 17-32. PMID 23228363 DOI: 10.1016/J.Jtbi.2012.11.018 |
0.359 |
|
2013 |
Zhang M, Ueki S, Kimura S, Yoshida O, Castellaneta A, Ozaki KS, Demetris AJ, Ross M, Vodovotz Y, Thomson AW, B Stolz D, Geller DA, Murase N. Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology (Baltimore, Md.). 57: 1585-96. PMID 23184590 DOI: 10.1002/Hep.26129 |
0.32 |
|
2013 |
Mathew S, Bartels J, Banerjee I, Vodovotz Y. Global sensitivity analysis of endotoxin-induced acute inflammatory responses predicts the multimodal dependence of global tissue damage both on host IL-6 responses and endotoxin dose Journal of Critical Care. 28: e12-e13. DOI: 10.1016/J.Jcrc.2012.10.039 |
0.311 |
|
2013 |
Starzl R, Wolfram D, Zamora R, Jefferson B, Barclay D, Ho C, Brandacher G, Schneeberger S, Lee WPA, Carbonell J, Vodovotz Y. Tissue-specific patterns of caspase-1 and cytokines in excisional wounds are altered by shock in rat skin and muscle Journal of Critical Care. 28. DOI: 10.1016/J.Jcrc.2012.10.038 |
0.305 |
|
2013 |
Azhar N, Namas R, Jefferson B, Barclay D, Zamora R, Vodovotz Y. Combined network and mathematical modeling suggests novel inflammation positive feedback circuit and role for IL-1α in experimental trauma/hemorrhage and hepatocyte hypoxia Journal of Critical Care. 28: e7. DOI: 10.1016/J.Jcrc.2012.10.029 |
0.77 |
|
2013 |
Scheff JD, Mavroudis PD, Foteinou PT, An G, Calvano SE, Doyle J, Dick TE, Lowry SF, Vodovotz Y, Androulakis IP. A multiscale modeling approach to inflammation: A case study in human endotoxemia Journal of Computational Physics. 244: 279-289. DOI: 10.1016/J.Jcp.2012.09.024 |
0.422 |
|
2013 |
Azhar N, Mi Q, Ziraldo C, Buliga M, Constantine GM, Vodovotz Y. Integrating data-driven and mechanistic models of the inflammatory response in sepsis and trauma Complex Systems and Computational Biology Approaches to Acute Inflammation. 143-157. DOI: 10.1007/978-1-4614-8008-2_8 |
0.798 |
|
2013 |
Stern JR, Ziraldo C, Vodovotz Y, An G. Agent-based models of wound healing Complex Systems and Computational Biology Approaches to Acute Inflammation. 209-228. DOI: 10.1007/978-1-4614-8008-2_12 |
0.718 |
|
2012 |
An G, Namas RA, Vodovotz Y. Sepsis: from pattern to mechanism and back. Critical Reviews in Biomedical Engineering. 40: 341-51. PMID 23140124 DOI: 10.1615/Critrevbiomedeng.V40.I4.80 |
0.337 |
|
2012 |
Vodovotz Y, Prelich J, Lagoa C, Barclay D, Zamora R, Murase N, Gandhi CR. Augmenter of liver regeneration (ALR) is a novel biomarker of hepatocellular stress/inflammation: in vitro, in vivo and in silico studies. Molecular Medicine (Cambridge, Mass.). 18: 1421-9. PMID 23073658 DOI: 10.2119/Molmed.2012.00183 |
0.37 |
|
2012 |
Sumpter TL, Dangi A, Matta BM, Huang C, Stolz DB, Vodovotz Y, Thomson AW, Gandhi CR. Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. Journal of Immunology (Baltimore, Md. : 1950). 189: 3848-58. PMID 22962681 DOI: 10.4049/Jimmunol.1200819 |
0.301 |
|
2012 |
Zamora R, Azhar N, Namas R, Metukuri MR, Clermont T, Gladstone C, Namas RA, Hermus L, Megas C, Constantine G, Billiar TR, Fink MP, Vodovotz Y. Identification of a novel pathway of transforming growth factor-β1 regulation by extracellular NAD+ in mouse macrophages: in vitro and in silico studies. The Journal of Biological Chemistry. 287: 31003-14. PMID 22829588 DOI: 10.1074/Jbc.M112.344309 |
0.743 |
|
2012 |
Dick TE, Molkov YI, Nieman G, Hsieh YH, Jacono FJ, Doyle J, Scheff JD, Calvano SE, Androulakis IP, An G, Vodovotz Y. Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling. Frontiers in Physiology. 3: 222. PMID 22783197 DOI: 10.3389/Fphys.2012.00222 |
0.397 |
|
2012 |
Namas RA, Namas R, Lagoa C, Barclay D, Mi Q, Zamora R, Peng Z, Wen X, Fedorchak MV, Valenti IE, Federspiel WJ, Kellum JA, Vodovotz Y. Hemoadsorption reprograms inflammation in experimental gram-negative septic peritonitis: insights from in vivo and in silico studies. Molecular Medicine (Cambridge, Mass.). 18: 1366-74. PMID 22751621 DOI: 10.2119/Molmed.2012.00106 |
0.393 |
|
2012 |
An G, Nieman G, Vodovotz Y. Toward computational identification of multiscale "tipping points" in acute inflammation and multiple organ failure. Annals of Biomedical Engineering. 40: 2414-24. PMID 22527009 DOI: 10.1007/S10439-012-0565-9 |
0.364 |
|
2012 |
Dangi A, Sumpter TL, Kimura S, Stolz DB, Murase N, Raimondi G, Vodovotz Y, Huang C, Thomson AW, Gandhi CR. Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance. Journal of Immunology (Baltimore, Md. : 1950). 188: 3667-77. PMID 22427640 DOI: 10.4049/Jimmunol.1102460 |
0.317 |
|
2012 |
Nieman G, Brown D, Sarkar J, Kubiak B, Ziraldo C, Dutta-Moscato J, Vieau C, Barclay D, Gatto L, Maier K, Constantine G, Billiar TR, Zamora R, Mi Q, Chang S, ... Vodovotz Y, et al. A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Critical Care Medicine. 40: 1052-63. PMID 22425816 DOI: 10.1097/Ccm.0B013E31823E986A |
0.775 |
|
2012 |
Lee JS, Sperry JL, Ochoa JB, Barclay D, Namas R, Vodovotz Y, Rosengart MR. Persistence of elevated plasma CXCL8 concentrations following red blood cell transfusion in a trauma cohort. Shock (Augusta, Ga.). 37: 373-7. PMID 22293598 DOI: 10.1097/Shk.0B013E31824Bcb72 |
0.32 |
|
2012 |
Roy SK, Kubiak BD, Albert SP, Vieau CJ, Gatto L, Golub L, Lee HM, Sookhu S, Vodovotz Y, Nieman GF. Chemically modified tetracycline 3 prevents acute respiratory distress syndrome in a porcine model of sepsis + ischemia/reperfusion-induced lung injury. Shock (Augusta, Ga.). 37: 424-32. PMID 22258231 DOI: 10.1097/Shk.0B013E318245F2F9 |
0.355 |
|
2012 |
Namas R, Zamora R, Namas R, An G, Doyle J, Dick TE, Jacono FJ, Androulakis IP, Nieman GF, Chang S, Billiar TR, Kellum JA, Angus DC, Vodovotz Y. Sepsis: Something old, something new, and a systems view. Journal of Critical Care. 27: 314.e1-11. PMID 21798705 DOI: 10.1016/J.Jcrc.2011.05.025 |
0.371 |
|
2012 |
Zaaqoq A, Namas R, Almahmoud K, Krishnan S, Azhar N, Ziraldo C, Mi Q, Zamora R, Brienza D, Vodovotz Y. 1064 Critical Care Medicine. 40: 1-328. DOI: 10.1097/01.Ccm.0000425277.23257.03 |
0.754 |
|
2012 |
Zamora R, Metukuri M, Namas R, Azhar N, Namas R, Constantine G, Billiar T, Fink M, Vodovotz Y. Induction and activation of macrophage transforming growth factor-β1 by extracellular nicotinamide adenine dinucleotide (NAD+) and its metabolite, cyclic ADP ribose: In vitro and in silico studies Journal of Critical Care. 27: e10. DOI: 10.1016/J.Jcrc.2012.01.030 |
0.722 |
|
2012 |
Scheff JD, Doyle J, Vodovotz Y, Androulakis IP. A stochastic analysis of the inflammatory response Journal of Critical Care. 27: e6-e7. DOI: 10.1016/J.Jcrc.2012.01.024 |
0.342 |
|
2012 |
Buchholz BM, Vodovotz Y, Barclay D, Shapiro RA, Billiar TR, Sodhi C, Hackam DJ, Bauer, PhD AJ. Non-vascular myocyte TLR4 regulates intestinal and systemic inflammation and prevents late ileus in murine endotoxemia Journal of the American College of Surgeons. 215: S23. DOI: 10.1016/J.Jamcollsurg.2012.06.081 |
0.322 |
|
2012 |
Ziraldo C, Nicholson Y, Thomson A, Vodovotz Y, Raimondi G. P172 Combined computational and experimental analyses of IL-6 and IL-1 reveal distinct mechanisms of action in the modulation of regulatory T cell suppressive activity Cytokine. 59: 575. DOI: 10.1016/J.Cyto.2012.06.274 |
0.746 |
|
2011 |
Li NY, Vodovotz Y, Kim KH, Mi Q, Hebda PA, Abbott KV. Biosimulation of acute phonotrauma: an extended model. The Laryngoscope. 121: 2418-28. PMID 22020892 DOI: 10.1002/Lary.22226 |
0.358 |
|
2011 |
Edmonds RD, Vodovotz Y, Lagoa C, Dutta-Moscato J, Yang Y, Fink MP, Levy RM, Prince JM, Kaczorowski DJ, Tseng GC, Billiar TR. Transcriptomic response of murine liver to severe injury and hemorrhagic shock: a dual-platform microarray analysis. Physiological Genomics. 43: 1170-83. PMID 21828244 DOI: 10.1152/Physiolgenomics.00020.2011 |
0.33 |
|
2011 |
Ramsgaard L, Englert JM, Manni ML, Milutinovic PS, Gefter J, Tobolewski J, Crum L, Coudriet GM, Piganelli J, Zamora R, Vodovotz Y, Enghild JJ, Oury TD. Lack of the receptor for advanced glycation end-products attenuates e. coli pneumonia in mice Plos One. 6. PMID 21629785 DOI: 10.1371/Journal.Pone.0020132 |
0.332 |
|
2011 |
Mi Q, Constantine G, Ziraldo C, Solovyev A, Torres A, Namas R, Bentley T, Billiar TR, Zamora R, Puyana JC, Vodovotz Y. A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. Plos One. 6: e19424. PMID 21573002 DOI: 10.1371/Journal.Pone.0019424 |
0.774 |
|
2011 |
An G, Bartels J, Vodovotz Y. In Silico Augmentation of the Drug Development Pipeline: Examples from the study of Acute Inflammation. Drug Development Research. 72: 187-200. PMID 21552346 DOI: 10.1002/Ddr.20415 |
0.301 |
|
2011 |
Brown BN, Price IM, Toapanta FR, DeAlmeida DR, Wiley CA, Ross TM, Oury TD, Vodovotz Y. An agent-based model of inflammation and fibrosis following particulate exposure in the lung. Mathematical Biosciences. 231: 186-96. PMID 21385589 DOI: 10.1016/J.Mbs.2011.03.005 |
0.39 |
|
2011 |
Menzel CL, Pfeifer R, Darwiche SS, Kobbe P, Gill R, Shapiro RA, Loughran P, Vodovotz Y, Scott MJ, Zenati MS, Billiar TR, Pape HC. Models of lower extremity damage in mice: time course of organ damage and immune response. The Journal of Surgical Research. 166: e149-56. PMID 21276982 DOI: 10.1016/J.Jss.2010.11.914 |
0.388 |
|
2011 |
Xiang M, Yin L, Li Y, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock activates lung endothelial reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase via neutrophil NADPH oxidase. American Journal of Respiratory Cell and Molecular Biology. 44: 333-40. PMID 20418360 DOI: 10.1165/Rcmb.2009-0408Oc |
0.31 |
|
2011 |
Jha S, Donze A, Khandpur R, Dutta-Moscato J, Mi Q, Vodovotz Y, Clermont G, Langmead C. Parameter estimation and synthesis for systems biology: New algorithms for nonlinear and stochastic models Journal of Critical Care. 26: e8. DOI: 10.1016/J.Jcrc.2010.12.031 |
0.328 |
|
2011 |
Mi Q, Constantine G, Ziraldo C, Solovyev A, Torres A, Namas R, Bentley T, Zamora R, Puyana JC, Vodovotz Y. Trauma/hemorrhage-induced inflammation in mice: Insights from data-driven models Journal of Critical Care. 26: e7. DOI: 10.1016/J.Jcrc.2010.12.030 |
0.761 |
|
2011 |
Ziraldo C, Ghuma A, Namas R, Ochoa J, Billiar TR, Zamora R, Mi Q, Vodovotz Y. Early prediction of length of intensive care unit stay from inflammatory mediators in trauma patients Journal of Critical Care. 26: e5-e6. DOI: 10.1016/J.Jcrc.2010.12.027 |
0.746 |
|
2011 |
Ghuma A, Giraldo C, Namas R, Ochoa J, Billiar T, Mi Q, Zamora R, Vodovotz Y. Data-driven segregation of trauma patients using principal component analysis yields novel, patient-specific insights into acute inflammation Journal of Critical Care. 26: e2. DOI: 10.1016/J.Jcrc.2010.12.020 |
0.347 |
|
2010 |
Solovyev A, Mikheev M, Zhou L, Dutta-Moscato J, Ziraldo C, An G, Vodovotz Y, Mi Q. SPARK: A Framework for Multi-Scale Agent-Based Biomedical Modeling. International Journal of Agent Technologies and Systems. 2: 18-30. PMID 24163721 DOI: 10.4018/jats.2010070102 |
0.734 |
|
2010 |
Mi Q, Li NY, Ziraldo C, Ghuma A, Mikheev M, Squires R, Okonkwo DO, Verdolini-Abbott K, Constantine G, An G, Vodovotz Y. Translational systems biology of inflammation: potential applications to personalized medicine. Personalized Medicine. 7: 549-559. PMID 21339856 DOI: 10.2217/Pme.10.45 |
0.771 |
|
2010 |
Vodovotz Y, An G. Systems biology and inflammation. Methods in Molecular Biology (Clifton, N.J.). 662: 181-201. PMID 20824472 DOI: 10.1007/978-1-60761-800-3_9 |
0.374 |
|
2010 |
Li NY, Vodovotz Y, Hebda PA, Abbott KV. Biosimulation of inflammation and healing in surgically injured vocal folds. The Annals of Otology, Rhinology, and Laryngology. 119: 412-23. PMID 20583741 DOI: 10.1177/000348941011900609 |
0.377 |
|
2010 |
Arciero JC, Ermentrout GB, Upperman JS, Vodovotz Y, Rubin JE. Using a mathematical model to analyze the role of probiotics and inflammation in necrotizing enterocolitis. Plos One. 5: e10066. PMID 20419099 DOI: 10.1371/Journal.Pone.0010066 |
0.338 |
|
2010 |
Vodovotz Y, Constantine G, Faeder J, Mi Q, Rubin J, Bartels J, Sarkar J, Squires RH, Okonkwo DO, Gerlach J, Zamora R, Luckhart S, Ermentrout B, An G. Translational systems approaches to the biology of inflammation and healing. Immunopharmacology and Immunotoxicology. 32: 181-95. PMID 20170421 DOI: 10.3109/08923970903369867 |
0.415 |
|
2010 |
Vodovotz Y. Translational systems biology of inflammation and healing. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 18: 3-7. PMID 20082674 DOI: 10.1111/J.1524-475X.2009.00566.X |
0.399 |
|
2010 |
Tyagi P, Barclay D, Zamora R, Yoshimura N, Peters K, Vodovotz Y, Chancellor M. Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. International Urology and Nephrology. 42: 629-35. PMID 19784793 DOI: 10.1007/S11255-009-9647-5 |
0.331 |
|
2009 |
Namas R, Ghuma A, Hermus L, Zamora R, Okonkwo DO, Billiar TR, Vodovotz Y. The acute inflammatory response in trauma / hemorrhage and traumatic brain injury: current state and emerging prospects. The Libyan Journal of Medicine. 4: 97-103. PMID 21483522 DOI: 10.4176/090325 |
0.429 |
|
2009 |
An G, Mi Q, Dutta-Moscato J, Vodovotz Y. Agent-based models in translational systems biology. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 1: 159-71. PMID 20835989 DOI: 10.1002/Wsbm.45 |
0.326 |
|
2009 |
Namas R, Ghuma A, Torres A, Polanco P, Gomez H, Barclay D, Gordon L, Zenker S, Kim HK, Hermus L, Zamora R, Rosengart MR, Clermont G, Peitzman A, Billiar TR, ... ... Vodovotz Y, et al. An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. Plos One. 4: e8406. PMID 20027315 DOI: 10.1371/Journal.Pone.0008406 |
0.351 |
|
2009 |
Li Y, Xiang M, Yuan Y, Xiao G, Zhang J, Jiang Y, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R1670-80. PMID 19828841 DOI: 10.1152/Ajpregu.00445.2009 |
0.331 |
|
2009 |
Tyagi P, Tyagi V, Yoshimura N, Witteemer E, Barclay D, Loughran PA, Zamora R, Vodovotz Y. Gender-based reciprocal expression of transforming growth factor-beta1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis. Journal of Inflammation (London, England). 6: 23. PMID 19691848 DOI: 10.1186/1476-9255-6-23 |
0.305 |
|
2009 |
Wognum S, Lagoa CE, Nagatomi J, Sacks MS, Vodovotz Y. An exploratory pathways analysis of temporal changes induced by spinal cord injury in the rat bladder wall: insights on remodeling and inflammation. Plos One. 4: e5852. PMID 19513121 DOI: 10.1371/Journal.Pone.0005852 |
0.319 |
|
2009 |
Metukuri MR, Beer-Stolz D, Namas RA, Dhupar R, Torres A, Loughran PA, Jefferson BS, Tsung A, Billiar TR, Vodovotz Y, Zamora R. Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G499-509. PMID 19147804 DOI: 10.1152/Ajpgi.90526.2008 |
0.322 |
|
2009 |
Liu Y, Yuan Y, Li Y, Zhang J, Xiao G, Vodovotz Y, Billiar TR, Wilson MA, Fan J. Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. Journal of Immunology (Baltimore, Md. : 1950). 182: 572-80. PMID 19109190 DOI: 10.4049/Jimmunol.182.1.572 |
0.325 |
|
2009 |
Torres A, Bentley T, Bartels J, Sarkar J, Barclay D, Namas R, Constantine G, Zamora R, Puyana JC, Vodovotz Y. Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock (Augusta, Ga.). 32: 172-8. PMID 19008782 DOI: 10.1097/Shk.0B013E318193Cc2B |
0.368 |
|
2009 |
Rivière B, Epshteyn Y, Swigon D, Vodovotz Y. A simple mathematical model of signaling resulting from the binding of lipopolysaccharide with Toll-like receptor 4 demonstrates inherent preconditioning behavior. Mathematical Biosciences. 217: 19-26. PMID 18950647 DOI: 10.1016/J.Mbs.2008.10.002 |
0.341 |
|
2009 |
Smaldone MC, Vodovotz Y, Tyagi V, Barclay D, Philips BJ, Yoshimura N, Chancellor MB, Tyagi P. Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Urology. 73: 421-6. PMID 18848347 DOI: 10.1016/J.Urology.2008.07.031 |
0.338 |
|
2009 |
Vodovotz Y, Constantine G, Rubin J, Csete M, Voit EO, An G. Mechanistic simulations of inflammation: current state and future prospects. Mathematical Biosciences. 217: 1-10. PMID 18835282 DOI: 10.1016/J.Mbs.2008.07.013 |
0.381 |
|
2009 |
Sarkar J, Marathe D, Inglis A, Hurst K, Kellum J, Angus D, Vodovotz Y, Chang S. Mathematical modeling of community-acquired pneumonia patients Critical Care. 13: 49. DOI: 10.1186/Cc8105 |
0.368 |
|
2009 |
Wolfram D, Starzl R, Barclay D, Vodovotz Y, Levine L, Wang Y, Gorantla V, Brandacher G, Lee A, Schneeberger S. OP25: A COMPUTATIONAL MODEL TO PROFILE CYTOKINE NETWORKS MEDIATING ACUTE REJECTION AFTER COMPOSITE TISSUE ALLOTRANSPLANTATION Plastic and Reconstructive Surgery. 124: 687-688. DOI: 10.1097/01.Prs.0000358929.94213.78 |
0.33 |
|
2009 |
Tyagi P, Jacobs BL, Barcaly D, Vodovotz Y, Leng WW, Kuo H, Chancellor MB. URINE LEVELS OF INFLAMMATORY CHEMOKINES CAN BE NOVEL BIOMARKERS FOR THE OVERACTIVE BLADDER The Journal of Urology. 181: 588. DOI: 10.1016/S0022-5347(09)61656-6 |
0.312 |
|
2009 |
Edmonds R, Lagoa C, Prince J, Levy R, Tseng G, Vodovotz Y, Billiar T. QS385. Temporal Transcriptomic Response of Murine Liver to Severe Injury and Hemorrhagic Shock Journal of Surgical Research. 151: 300. DOI: 10.1016/J.Jss.2008.11.695 |
0.315 |
|
2009 |
Ghuma A, Namas R, Ziraldo C, Ochoa J, Billiar TR, Zamora R, Mi Q, Vodovotz Y. Principal component analysis delineates both subgroup- and patient-specific insights into acute inflammation in trauma patients Journal of Critical Care. 24: e24. DOI: 10.1016/J.Jcrc.2009.06.026 |
0.739 |
|
2009 |
Vodovotz Y, Chang S, Barclay D, Kubiak B, Vieau C, Gatto L, Maier K, Ziraldo C, Mi Q, Zamora R, Nieman G. Porcine endotoxemia: Multiplexed cytokine analysis and mathematical modeling Journal of Critical Care. 24: e23. DOI: 10.1016/J.Jcrc.2009.06.024 |
0.752 |
|
2008 |
Li NY, Verdolini K, Clermont G, Mi Q, Rubinstein EN, Hebda PA, Vodovotz Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. Plos One. 3: e2789. PMID 18665229 DOI: 10.1371/Journal.Pone.0002789 |
0.389 |
|
2008 |
Kobbe P, Vodovotz Y, Kaczorowski DJ, Mollen KP, Billiar TR, Pape HC. Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock (Augusta, Ga.). 30: 43-7. PMID 18562923 DOI: 10.1097/Shk.0B013E31815D190B |
0.307 |
|
2008 |
Daun S, Rubin J, Vodovotz Y, Roy A, Parker R, Clermont G. An ensemble of models of the acute inflammatory response to bacterial lipopolysaccharide in rats: Results from parameter space reduction Journal of Theoretical Biology. 253: 843-853. PMID 18550083 DOI: 10.1016/J.Jtbi.2008.04.033 |
0.374 |
|
2008 |
Bagci EZ, Vodovotz Y, Billiar TR, Ermentrout B, Bahar I. Computational insights on the competing effects of nitric oxide in regulating apoptosis. Plos One. 3: e2249. PMID 18509469 DOI: 10.1371/Journal.Pone.0002249 |
0.302 |
|
2008 |
Kobbe P, Kaczorowski DJ, Vodovotz Y, Tzioupis CH, Mollen KP, Billiar TR, Pape HC. Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock (Augusta, Ga.). 30: 686-91. PMID 18461022 DOI: 10.1097/Shk.0B013E31816F257E |
0.333 |
|
2008 |
Vodovotz Y, Csete M, Bartels J, Chang S, An G. Translational systems biology of inflammation. Plos Computational Biology. 4: e1000014. PMID 18437239 DOI: 10.1371/Journal.Pcbi.1000014 |
0.352 |
|
2008 |
An G, Faeder J, Vodovotz Y. Translational systems biology: Introduction of an engineering approach to the pathophysiology of the burn patient Journal of Burn Care and Research. 29: 277-285. PMID 18354282 DOI: 10.1097/Bcr.0B013E31816677C8 |
0.377 |
|
2008 |
Mollen KP, Levy RM, Prince JM, Hoffman RA, Scott MJ, Kaczorowski DJ, Vallabhaneni R, Vodovotz Y, Billiar TR. Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. Journal of Leukocyte Biology. 83: 80-8. PMID 17925504 DOI: 10.1189/Jlb.0407201 |
0.339 |
|
2007 |
Mi Q, Rivière B, Clermont G, Steed DL, Vodovotz Y. Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 15: 671-82. PMID 17971013 DOI: 10.1111/J.1524-475X.2007.00271.X |
0.316 |
|
2007 |
Mi Q, Swigon D, Rivière B, Cetin S, Vodovotz Y, Hackam DJ. One-dimensional elastic continuum model of enterocyte layer migration. Biophysical Journal. 93: 3745-52. PMID 17704181 DOI: 10.1529/Biophysj.107.112326 |
0.323 |
|
2007 |
Levy RM, Mollen KP, Prince JM, Kaczorowski DJ, Vallabhaneni R, Liu S, Tracey KJ, Lotze MT, Hackam DJ, Fink MP, Vodovotz Y, Billiar TR. Systemic inflammation and remote organ injury following trauma require HMGB1. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R1538-44. PMID 17652366 DOI: 10.1152/Ajpregu.00272.2007 |
0.38 |
|
2007 |
An G, Hunt CA, Clermont G, Neugebauer E, Vodovotz Y. Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams Journal of Critical Care. 22: 169-175. PMID 17548029 DOI: 10.1016/J.Jcrc.2006.12.011 |
0.33 |
|
2007 |
Fan J, Li Y, Vodovotz Y, Billiar TR, Wilson MA. Neutrophil NAD(P)H oxidase is required for hemorrhagic shock-enhanced TLR2 up-regulation in alveolar macrophages in response to LPS. Shock (Augusta, Ga.). 28: 213-8. PMID 17515854 DOI: 10.1097/Shk.0B013E318033Ec9D |
0.344 |
|
2007 |
Fan J, Li Y, Levy RM, Fan JJ, Hackam DJ, Vodovotz Y, Yang H, Tracey KJ, Billiar TR, Wilson MA. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. Journal of Immunology (Baltimore, Md. : 1950). 178: 6573-80. PMID 17475888 DOI: 10.4049/Jimmunol.178.10.6573 |
0.317 |
|
2007 |
Vodovotz Y, Clermont G, Hunt CA, Lefering R, Bartels J, Seydel R, Hotchkiss J, Ta'asan S, Neugebauer E, An G. Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness. Journal of Critical Care. 22: 77-84. PMID 17371750 DOI: 10.1016/J.Jcrc.2006.12.001 |
0.337 |
|
2007 |
Vodovotz Y. Deciphering the complexity of acute inflammation using mathematical models. Immunologic Research. 36: 237-45. PMID 17337784 DOI: 10.1385/Ir:36:1:237 |
0.406 |
|
2007 |
Upperman JS, Camerini V, Lugo B, Yotov I, Sullivan J, Rubin J, Rubin J, Clermont G, Zamora R, Ermentrout GB, Ford HR, Vodovotz Y. Mathematical modeling in necrotizing enterocolitis--a new look at an ongoing problem. Journal of Pediatric Surgery. 42: 445-53. PMID 17336179 DOI: 10.1016/J.Jpedsurg.2006.10.053 |
0.377 |
|
2007 |
Prince JM, Ming MJ, Levy RM, Liu S, Pinsky DJ, Vodovotz Y, Billiar TR. Early growth response 1 mediates the systemic and hepatic inflammatory response initiated by hemorrhagic shock. Shock (Augusta, Ga.). 27: 157-64. PMID 17224790 DOI: 10.1097/01.Shk.0000245025.01365.8E |
0.361 |
|
2007 |
Lagoa C, Prince J, Levy R, Vodovotz Y, Tseng G, Yang Y, Heckman C, Fink M, Billiar T. A temporal analysis of the hepatic transcriptomic response to bone fracture and hemorrhagic shock in mice Journal of Critical Care. 22: 335. DOI: 10.1016/J.Jcrc.2007.10.007 |
0.3 |
|
2006 |
Lagoa CE, Bartels J, Baratt A, Tseng G, Clermont G, Fink MP, Billiar TR, Vodovotz Y. The role of initial trauma in the host's response to injury and hemorrhage: insights from a correlation of mathematical simulations and hepatic transcriptomic analysis. Shock (Augusta, Ga.). 26: 592-600. PMID 17117135 DOI: 10.1097/01.Shk.0000232272.03602.0A |
0.413 |
|
2006 |
Prince JM, Levy RM, Bartels J, Baratt A, Kane JM, Lagoa C, Rubin J, Day J, Wei J, Fink MP, Goyert SM, Clermont G, Billiar TR, Vodovotz Y. In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Molecular Medicine (Cambridge, Mass.). 12: 88-96. PMID 16953560 DOI: 10.2119/2006-00012.Prince |
0.349 |
|
2006 |
Vodovotz Y, Chow CC, Bartels J, Lagoa C, Prince JM, Levy RM, Kumar R, Day J, Rubin J, Constantine G, Billiar TR, Fink MP, Clermont G. In silico models of acute inflammation in animals. Shock (Augusta, Ga.). 26: 235-44. PMID 16912648 DOI: 10.1097/01.Shk.0000225413.13866.Fo |
0.425 |
|
2006 |
Levy RM, Prince JM, Yang R, Mollen KP, Liao H, Watson GA, Fink MP, Vodovotz Y, Billiar TR. Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 291: R970-6. PMID 16675630 DOI: 10.1152/Ajpregu.00793.2005 |
0.377 |
|
2006 |
Day J, Rubin J, Vodovotz Y, Chow CC, Reynolds A, Clermont G. A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. Journal of Theoretical Biology. 242: 237-56. PMID 16616206 DOI: 10.1016/J.Jtbi.2006.02.015 |
0.395 |
|
2006 |
Reynolds A, Rubin J, Clermont G, Day J, Vodovotz Y, Bard Ermentrout G. A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation Journal of Theoretical Biology. 242: 220-236. PMID 16584750 DOI: 10.1016/J.Jtbi.2006.02.016 |
0.41 |
|
2006 |
Prince JM, Levy RM, Yang R, Mollen KP, Fink MP, Vodovotz Y, Billiar TR. Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. Journal of the American College of Surgeons. 202: 407-17. PMID 16500244 DOI: 10.1016/J.Jamcollsurg.2005.11.021 |
0.337 |
|
2006 |
Fan J, Li Y, Vodovotz Y, Billiar TR, Wilson MA. Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L738-L746. PMID 16272176 DOI: 10.1152/Ajplung.00280.2005 |
0.366 |
|
2006 |
Vodovotz Y. COMBINED IN SILICO AND IN VIVO STUDIES ON ACUTE INFLAMMATION Shock. 26: 1. DOI: 10.1097/00024382-200610001-00004 |
0.34 |
|
2006 |
Vodovotz Y, Hoffman R, Barratt A, Wei J, Lagoa C, Billiar T, Clermont G, Bartels J. IN SILICO AND IN VIVO STUDIES MODELING THE AGED ACUTE INFLAMMATORY RESPONSE Shock. 25: 39-40. DOI: 10.1097/00024382-200606001-00118 |
0.357 |
|
2006 |
Levy R, Prince J, Mollen K, Watson G, Tracey K, Fink M, Vodovotz Y, Billiar T. HEPATIC INJURY AND SYSTEMIC INFLAMMATION AFTER TRAUMA REQUIRES TLR4 AND IS MEDIATED BY HMGB1 Shock. 25: 2. DOI: 10.1097/00024382-200606001-00006 |
0.362 |
|
2006 |
Levy R, Prince J, Mollen K, Yang R, Fink M, Vodovotz Y, Billiar T. Systemic inflammation and liver dysfunction after trauma is Toll-like receptor 4 (TLR-4) dependent Journal of Surgical Research. 130: 173. DOI: 10.1016/J.Jss.2005.11.037 |
0.309 |
|
2006 |
Lagoa C, Bartels J, Baratt A, Clermont G, Fink M, Billiar T, Vodovotz Y. From mice to rats: interspecies prediction of the systemic inflammatory response using mathematical simulations Journal of Critical Care. 21: 355-356. DOI: 10.1016/J.Jcrc.2006.10.022 |
0.314 |
|
2006 |
Torres A, Polanco P, Hyung K, Pinsky M, Bartels J, Zenker S, Clermont G, Puyana J, Bentley T, Vodovotz Y. PCO2 as surrogate for mathematically-modeled tissue dysfunction/damage during a nonlethal hemorrhagic shock model in mice Journal of Critical Care. 21: 352-353. DOI: 10.1016/J.Jcrc.2006.10.017 |
0.301 |
|
2006 |
Mollen KP, Prince J, Levy R, Scott M, Watson G, Kaczorowski D, Kohut LK, Rosemary H, Vodovotz Y, Billiar T. TLR4-competent hematopoietic cells are required for systemic inflammation and hepatic injury after trauma/hemorrhage Journal of the American College of Surgeons. 203: S42. DOI: 10.1016/J.Jamcollsurg.2006.05.098 |
0.356 |
|
2005 |
Lagoa CE, Vodovotz Y, Stolz DB, Lhuillier F, McCloskey C, Gallo D, Yang R, Ustinova E, Fink MP, Billiar TR, Mars WM. The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock Hepatology. 42: 390-399. PMID 16025510 DOI: 10.1002/Hep.20797 |
0.304 |
|
2005 |
Chow CC, Clermont G, Kumar R, Lagoa C, Tawadrous Z, Gallo D, Betten B, Bartels J, Constantine G, Fink MP, Billiar TR, Vodovotz Y. The acute inflammatory response in diverse shock states. Shock (Augusta, Ga.). 24: 74-84. PMID 15988324 DOI: 10.1097/01.Shk.0000168526.97716.F3 |
0.43 |
|
2005 |
Scott MJ, Liu S, Su GL, Vodovotz Y, Billiar TR. Hepatocytes enhance effects of lipopolysaccharide on liver nonparenchymal cells through close cell interactions. Shock (Augusta, Ga.). 23: 453-8. PMID 15834312 DOI: 10.1097/01.Shk.0000160939.08385.F1 |
0.305 |
|
2005 |
Lagoa C, Chow C, Bartels J, Barrat A, Kumar R, Day J, Rubin J, Constantine G, Chang S, Fink M, Billiar T, Clermont G, Vodovotz Y. Mathematical models predict the course of the inflammatory response in rats subjected to trauma-hemorrhagic shock and to anti–tumor necrosis factor α therapy in endotoxemia Journal of Critical Care. 20: 393-394. DOI: 10.1016/J.Jcrc.2005.09.046 |
0.329 |
|
2005 |
Day J, Rubin J, Vodovotz Y, Chow C, Clermont C. Capturing scenarios of repeated endotoxin administrations in a small mathematical model of the acute inflammatory response and mathematically exploring the nature of tolerance Journal of Critical Care. 20: 391-392. DOI: 10.1016/J.Jcrc.2005.09.042 |
0.364 |
|
2004 |
Vodovotz Y, Kim PK, Bagci EZ, Ermentrout GB, Chow CC, Bahar I, Billiar TR. Inflammatory modulation of hepatocyte apoptosis by nitric oxide: in vivo, in vitro, and in silico studies. Current Molecular Medicine. 4: 753-62. PMID 15579022 DOI: 10.2174/1566524043359944 |
0.337 |
|
2004 |
Clermont G, Bartels J, Kumar R, Constantine G, Vodovotz Y, Chow C. In silico design of clinical trials: a method coming of age. Critical Care Medicine. 32: 2061-70. PMID 15483415 DOI: 10.1097/01.Ccm.0000142394.28791.C3 |
0.326 |
|
2004 |
Vodovotz Y, Clermont G, Chow C, An G. Mathematical models of the acute inflammatory response Current Opinion in Critical Care. 10: 383-390. PMID 15385756 DOI: 10.1097/01.Ccx.0000139360.30327.69 |
0.405 |
|
2004 |
Kumar R, Clermont G, Vodovotz Y, Chow CC. The dynamics of acute inflammation. Journal of Theoretical Biology. 230: 145-55. PMID 15321710 DOI: 10.1016/J.Jtbi.2004.04.044 |
0.366 |
|
2004 |
Kim PKM, Zuckerbraun BS, Otterbein LE, Vodovotz Y, Billiar TR. 'Til cell death do us part: Nitric oxide and mechanisms of hepatotoxicity Biological Chemistry. 385: 11-15. PMID 14977041 DOI: 10.1515/Bc.2004.002 |
0.306 |
|
2004 |
Vodovotz Y, Lagoa C, Day J, Kumar R, Chow C, Fink MP, Billiar TR, Clermont G. PREDICTING THE ACUTE INFLAMMATORY RESPONSE IN COMBINED TRAUMA-HEMORRHAGE AND ENDOTOXEMIA USING MATHEMATICAL SIMULATIONS Shock. 21: 50. DOI: 10.1097/00024382-200406002-00146 |
0.357 |
|
2004 |
Vodovotz Y, Clermont G, Bartels J, Constantine G, Chow C. VALIDATION AND CALIBRATION IN ANIMALS OF A MATHEMATICAL MODEL OF ACUTE INFLAMMATION Shock. 21: 98. DOI: 10.1097/00024382-200403001-00392 |
0.338 |
|
2003 |
Collins JL, Vodovotz Y, Hierholzer C, Villavicencio RT, Liu S, Alber S, Gallo D, Stolz DB, Watkins SC, Godfrey A, Gooding W, Kelly E, Peitzman AB, Billiar TR. Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. Shock (Augusta, Ga.). 19: 117-22. PMID 12578118 DOI: 10.1097/00024382-200302000-00005 |
0.313 |
|
2003 |
Schwentker A, Vodovotz Y, Weller R, Billiar TR. Nitric oxide and wound repair: role of cytokines? Nitric Oxide : Biology and Chemistry. 7: 1-10. PMID 12175813 DOI: 10.1016/S1089-8603(02)00002-2 |
0.335 |
|
2003 |
Lagoa CE, Clermont G, Kumar R, Bartels J, Chow CC, Vodovotz Y. Prediction of the Acute Inflammatory Response From A Mathematical Mode Chest. 124: 121S. DOI: 10.1378/Chest.124.4_Meetingabstracts.121S-A |
0.317 |
|
2003 |
Lagoa C, Lhuillier F, McCloskey C, Vodovotz Y, Mars W, Yang R, Fink M, Billiar; TR. PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) IS REGULATED BY iNOS DURING HEMORRHAGIC SHOCK AND IS INVOLVED IN PRO-INFLAMMATORY SIGNALING AND TISSUE INJURY. Shock. 19: 51. DOI: 10.1097/00024382-200306001-00150 |
0.354 |
|
2002 |
Zamora R, Vodovotz Y, Aulak KS, Kim PKM, Kane JM, Alarcon L, Stuehr DJ, Billiar TR. A DNA microarray study of nitric oxide-induced genes in mouse hepatocytes: Implications for hepatic heme oxygenase-1 expression in ischemia/reperfusion Nitric Oxide - Biology and Chemistry. 7: 165-186. PMID 12381414 DOI: 10.1016/S1089-8603(02)00104-0 |
0.337 |
|
2001 |
Collins JL, Vodovotz Y, Yoneyama T, Hatakeyama K, Green AM, Billiar TR. Catecholamines decrease nitric oxide production by cytokine-stimulated hepatocytes. Surgery. 130: 256-64. PMID 11490358 DOI: 10.1067/Msy.2001.115900 |
0.31 |
|
2001 |
Vodovotz Y, Liu S, McCloskey C, Shapiro R, Green A, Billiar TR. The hepatocyte as a microbial product-responsive cell. Journal of Endotoxin Research. 7: 365-373. DOI: 10.1177/09680519010070050401 |
0.305 |
|
2000 |
Liu S, Salyapongse AN, Geller DA, Vodovotz Y, Billiar TR. Hepatocyte Toll-Like Receptor 2 expression in vivo and in vitro: Role of cytokines in induction of rat TLR2 gene expression by lipopolysaccharide Shock. 14: 361-365. PMID 11028557 DOI: 10.1097/00024382-200014030-00021 |
0.31 |
|
2000 |
Zamora R, Vodovotz Y, Billiar TR. Inducible Nitric Oxide Synthase and Inflammatory Diseases Molecular Medicine. 6: 347-373. DOI: 10.1007/Bf03401781 |
0.383 |
|
1994 |
Bogdan C, Vodovotz Y, Paik J, Xie QW, Nathan C. Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages. Journal of Leukocyte Biology. 55: 227-33. PMID 7507968 DOI: 10.1002/Jlb.55.2.227 |
0.323 |
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