Peter C. Ruben - Publications

Simon Fraser University, Burnaby, British Columbia, Canada 
Sodium channels

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ghovanloo MR, Atallah J, Escudero CA, Ruben PC. Biophysical Characterization of a Novel Mutation Associated With an Atypical Phenotype of Atrial and Ventricular Arrhythmias and Sudden Death. Frontiers in Physiology. 11: 610436. PMID 33414724 DOI: 10.3389/fphys.2020.610436  1
2020 Sait LG, Sula A, Ghovanloo MR, Hollingworth D, Ruben PC, Wallace BA. Cannabidiol interactions with voltage-gated sodium channels. Elife. 9. PMID 33089780 DOI: 10.7554/eLife.58593  1
2020 Peters CH, Watkins AR, Poirier OL, Ruben PC. E1784K, the most common Brugada syndrome and long-QT syndrome type 3 mutant, disrupts sodium channel inactivation through two separate mechanisms. The Journal of General Physiology. 152. PMID 32569350 DOI: 10.1085/jgp.202012595  0.88
2020 Ghovanloo MR, Ruben PC. Say Cheese: Structure of the Cardiac Electrical Engine Is Captured. Trends in Biochemical Sciences. 45: 369-371. PMID 32311330 DOI: 10.1016/j.tibs.2020.02.003  1
2020 Fouda MA, Ghovanloo MR, Ruben PC. Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels. British Journal of Pharmacology. PMID 32077098 DOI: 10.1111/bph.15020  1
2019 Angus M, Peters CH, Poburko D, Brimble E, Spelbrink EM, Ruben PC. Case Studies in Neuroscience: A Novel Amino Acid Duplication in the N-terminus of the Brain Sodium Channel Na1.1 Underlying Dravet Syndrome. Journal of Neurophysiology. PMID 31533007 DOI: 10.1152/jn.00491.2019  0.88
2018 Ghovanloo MR, Peters CH, Ruben PC. Effects of Acidosis on Neuronal Voltage-Gated Sodium Channels: Nav1.1 and Nav1.3. Channels (Austin, Tex.). PMID 30362397 DOI: 10.1080/19336950.2018.1539611  1
2018 Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ. Inhibitory effects of cannabidiol on voltage-dependent sodium currents. The Journal of Biological Chemistry. PMID 30219789 DOI: 10.1074/jbc.RA118.004929  1
2018 Baruteau AE, Kyndt F, Behr ER, Vink AS, Lachaud M, Joong A, Schott JJ, Horie M, Denjoy I, Crotti L, Shimizu W, Bos JM, Stephenson EA, Wong L, Abrams DJ, ... ... Ruben PC, et al. SCN5A mutations in 442 neonates and children: genotype-phenotype correlation and identification of higher-risk subgroups. European Heart Journal. PMID 30059973 DOI: 10.1093/eurheartj/ehy412  0.56
2018 Ghovanloo MR, Abdelsayed M, Peters CH, Ruben PC. A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels. Scientific Reports. 8: 6304. PMID 29674667 DOI: 10.1038/s41598-018-24719-y  1
2018 Abdelsayed M, Ruprai M, Ruben PC. The efficacy of Ranolazine on E1784K is altered by temperature and calcium. Scientific Reports. 8: 3643. PMID 29483621 DOI: 10.1038/s41598-018-22033-1  0.56
2018 Peters CH, Ghovanloo MR, Gershome C, Ruben PC. pH Modulation of Voltage-Gated Sodium Channels. Handbook of Experimental Pharmacology. PMID 29460150 DOI: 10.1007/164_2018_99  1
2017 Abdelsayed M, Peters CH, Ruben PC. Arrhythmogenic Triggers Associated with Sudden Cardiac Death. Channels (Austin, Tex.). 0. PMID 28976236 DOI: 10.1080/19336950.2017.1388057  0.88
2017 Thibodeau ML, Peters CH, Townsend KN, Shen Y, Hendson G, Adam S, Selby K, Macleod PM, Gershome C, Ruben P, Jones SJM, Friedman JM, Gibson WT, Horvath GA. Compound heterozygous TRPV4 mutations in two siblings with a complex phenotype including severe intellectual disability and neuropathy. American Journal of Medical Genetics. Part A. PMID 28898540 DOI: 10.1002/ajmg.a.38400  0.88
2017 Peters CH, Yu A, Zhu W, Silva JR, Ruben PC. Depolarization of the conductance-voltage relationship in the NaV1.5 mutant, E1784K, is due to altered fast inactivation. Plos One. 12: e0184605. PMID 28898267 DOI: 10.1371/journal.pone.0184605  0.88
2017 Abdelsayed M, Baruteau AE, Gibbs K, Sanatani S, Krahn AD, Probst V, Ruben PC. Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants. The Journal of Physiology. PMID 28734073 DOI: 10.1113/JP274536  0.56
2016 Ghovanloo MR, Aimar K, Ghadiry-Tavi R, Yu A, Ruben PC. Physiology and Pathophysiology of Sodium Channel Inactivation. Current Topics in Membranes. 78: 479-509. PMID 27586293 DOI: 10.1016/bs.ctm.2016.04.001  1
2016 Peters C, Rosch RE, Hughes E, Ruben PC. Temperature-dependent changes in neuronal dynamics in a patient with an SCN1A mutation and hyperthermia induced seizures. Scientific Reports. 6: 31879. PMID 27582020 DOI: 10.1038/srep31879  1
2016 Ghovanloo MR, Abdelsayed M, Ruben PC. Effects of Amiodarone and N-desethylamiodarone on Cardiac Voltage-Gated Sodium Channels. Frontiers in Pharmacology. 7: 39. PMID 26973526 DOI: 10.3389/fphar.2016.00039  1
2015 Peters CH, Abdelsayed M, Ruben PC. Triggers for arrhythmogenesis in the Brugada and long QT 3 syndromes. Progress in Biophysics and Molecular Biology. PMID 26713557 DOI: 10.1016/j.pbiomolbio.2015.12.009  1
2015 Zaharieva IT, Thor MG, Oates EC, van Karnebeek C, Hendson G, Blom E, Witting N, Rasmussen M, Gabbett MT, Ravenscroft G, Sframeli M, Suetterlin K, Sarkozy A, D'Argenzio L, Hartley L, ... ... Ruben P, et al. Loss-of-function mutations in SCN4A cause severe foetal hypokinesia or 'classical' congenital myopathy. Brain : a Journal of Neurology. PMID 26700687 DOI: 10.1093/brain/awv352  1
2015 Abdelsayed M, Peters CH, Ruben PC. Differential thermosensitivity in mixed syndrome cardiac sodium channel mutants. The Journal of Physiology. 593: 4201-23. PMID 26131924 DOI: 10.1113/JP270139  1
2014 Jones DK, Ruben PC. Proton modulation of cardiac I Na: a potential arrhythmogenic trigger. Handbook of Experimental Pharmacology. 221: 169-81. PMID 24737236 DOI: 10.1007/978-3-642-41588-3_8  1
2014 Peters CH, Ruben PC. Introduction to sodium channels. Handbook of Experimental Pharmacology. 221: 1-6. PMID 24737229 DOI: 10.1007/978-3-642-41588-3_1  1
2013 Abdelsayed M, Sokolov S, Ruben PC. A thermosensitive mutation alters the effects of lacosamide on slow inactivation in neuronal voltage-gated sodium channels, NaV1.2. Frontiers in Pharmacology. 4: 121. PMID 24065921 DOI: 10.3389/fphar.2013.00121  1
2013 Jones DK, Claydon TW, Ruben PC. Extracellular protons inhibit charge immobilization in the cardiac voltage-gated sodium channel. Biophysical Journal. 105: 101-7. PMID 23823228 DOI: 10.1016/j.bpj.2013.04.022  1
2013 Sokolov S, Peters CH, Rajamani S, Ruben PC. Proton-dependent inhibition of the cardiac sodium channel Nav1.5 by ranolazine. Frontiers in Pharmacology. 4: 78. PMID 23801963 DOI: 10.3389/fphar.2013.00078  1
2013 Peters CH, Sokolov S, Rajamani S, Ruben PC. Effects of the antianginal drug, ranolazine, on the brain sodium channel Na(V)1.2 and its modulation by extracellular protons. British Journal of Pharmacology. 169: 704-16. PMID 23472826 DOI: 10.1111/bph.12150  1
2013 Jones DK, Peters CH, Allard CR, Claydon TW, Ruben PC. Proton sensors in the pore domain of the cardiac voltage-gated sodium channel. The Journal of Biological Chemistry. 288: 4782-91. PMID 23283979 DOI: 10.1074/jbc.M112.434266  1
2012 Vilin YY, Peters CH, Ruben PC. Acidosis differentially modulates inactivation in na(v)1.2, na(v)1.4, and na(v)1.5 channels. Frontiers in Pharmacology. 3: 109. PMID 22701426 DOI: 10.3389/fphar.2012.00109  1
2012 Egri C, Ruben PC. A hot topic: temperature sensitive sodium channelopathies. Channels (Austin, Tex.). 6: 75-85. PMID 22643347 DOI: 10.4161/chan.19827  1
2012 Egri C, Vilin YY, Ruben PC. A thermoprotective role of the sodium channel β1 subunit is lost with the β1 (C121W) mutation. Epilepsia. 53: 494-505. PMID 22292491 DOI: 10.1111/j.1528-1167.2011.03389.x  1
2011 Jones DK, Peters CH, Tolhurst SA, Claydon TW, Ruben PC. Extracellular proton modulation of the cardiac voltage-gated sodium channel, Nav1.5. Biophysical Journal. 101: 2147-56. PMID 22067152 DOI: 10.1016/j.bpj.2011.08.056  1
2011 Lee CH, Jones DK, Ahern C, Sarhan MF, Ruben PC. Biophysical costs associated with tetrodotoxin resistance in the sodium channel pore of the garter snake, Thamnophis sirtalis. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 197: 33-43. PMID 20820785 DOI: 10.1007/s00359-010-0582-9  1
2008 Lee CH, Ruben PC. Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin. Channels (Austin, Tex.). 2: 407-12. PMID 19098433 DOI: 10.4161/chan.2.6.7429  1
2008 Jones DK, Ruben PC. Biophysical defects in voltage.gated sodium channels associated with long QT and Brugada syndromes. Channels (Austin, Tex.). 2: 70-80. PMID 18849657 DOI: 10.4161/chan.2.2.6000  1
2008 Sun H, Varela D, Chartier D, Ruben PC, Nattel S, Zamponi GW, Leblanc N. Differential interactions of Na+ channel toxins with T-type Ca2+ channels. The Journal of General Physiology. 132: 101-13. PMID 18591418 DOI: 10.1085/jgp.200709883  1
2008 Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ. Action potential generation requires a high sodium channel density in the axon initial segment. Nature Neuroscience. 11: 178-86. PMID 18204443 DOI: 10.1038/nn2040  1
2007 Groome JR, Dice MC, Fujimoto E, Ruben PC. Charge immobilization of skeletal muscle Na+ channels: role of residues in the inactivation linker. Biophysical Journal. 93: 1519-33. PMID 17513361 DOI: 10.1529/biophysj.106.102079  1
2006 Dice MS, Kearl T, Ruben PC. Methods for studying voltage-gated sodium channels in heterologous expression systems. Methods in Molecular Medicine. 129: 163-85. PMID 17085811 DOI: 10.1385/1-59745-213-0:163  1
2006 Salvador-Recatalà V, Gallin WJ, Abbruzzese J, Ruben PC, Spencer AN. A potassium channel (Kv4) cloned from the heart of the tunicate Ciona intestinalis and its modulation by a KChIP subunit. The Journal of Experimental Biology. 209: 731-47. PMID 16449567 DOI: 10.1242/jeb.02032  1
2006 Geffeney SL, Ruben PC. The structural basis and functional consequences of interactions between tetrodotoxin and voltage-gated sodium channels Marine Drugs. 4: 143-156. DOI: 10.3390/md403143  1
2005 Groome JR, Fujimoto E, Ruben PC. K-aggravated myotonia mutations at residue G1306 differentially alter deactivation gating of human skeletal muscle sodium channels. Cellular and Molecular Neurobiology. 25: 1075-92. PMID 16392038 DOI: 10.1007/s10571-005-8057-1  1
2005 Geffeney SL, Fujimoto E, Brodie ED, Brodie ED, Ruben PC. Evolutionary diversification of TTX-resistant sodium channels in a predator-prey interaction. Nature. 434: 759-63. PMID 15815629 DOI: 10.1038/nature03444  1
2004 Dice MS, Abbruzzese JL, Wheeler JT, Groome JR, Fujimoto E, Ruben PC. Temperature-sensitive defects in paramyotonia congenita mutants R1448C and T1313M. Muscle & Nerve. 30: 277-88. PMID 15318338 DOI: 10.1002/mus.20080  1
2003 Locher CP, Ruben PC, Gut J, Rosenthal PJ. 5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Antimicrobial Agents and Chemotherapy. 47: 3806-9. PMID 14638487 DOI: 10.1128/AAC.47.12.3806-3809.2003  1
2003 McCollum IJ, Vilin YY, Spackman E, Fujimoto E, Ruben PC. Negatively charged residues adjacent to IFM motif in the DIII-DIV linker of hNa(V)1.4 differentially affect slow inactivation. Febs Letters. 552: 163-9. PMID 14527681 DOI: 10.1016/S0014-5793(03)00912-8  1
2003 Groome JR, Fujimoto E, Ruben PC. Negative charges in the DIII-DIV linker of human skeletal muscle Na+ channels regulate deactivation gating. The Journal of Physiology. 548: 85-96. PMID 12588896 DOI: 10.1113/jphysiol.2002.033084  1
2002 Geffeney S, Brodie ED, Ruben PC, Brodie ED. Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels. Science (New York, N.Y.). 297: 1336-9. PMID 12193784 DOI: 10.1126/science.1074310  1
2002 Groome J, Fujimoto E, Walter L, Ruben P. Outer and central charged residues in DIVS4 of skeletal muscle sodium channels have differing roles in deactivation. Biophysical Journal. 82: 1293-307. PMID 11867446 DOI: 10.1016/S0006-3495(02)75485-4  1
2001 Vilin YY, Ruben PC. Slow inactivation in voltage-gated sodium channels: molecular substrates and contributions to channelopathies. Cell Biochemistry and Biophysics. 35: 171-90. PMID 11892790 DOI: 10.1385/CBB:35:2:171  1
2001 Vilin YY, Fujimoto E, Ruben PC. A novel mechanism associated with idiopathic ventricular fibrillation (IVF) mutations R1232W and T1620M in human cardiac sodium channels. PflüGers Archiv : European Journal of Physiology. 442: 204-11. PMID 11417215 DOI: 10.1007/s004240100529  1
2001 Vilin YY, Fujimoto E, Ruben PC. A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation. Biophysical Journal. 80: 2221-30. PMID 11325725 DOI: 10.1016/S0006-3495(01)76195-4  1
2000 Groome JR, Fujimoto E, Ruben PC. The delay in recovery from fast inactivation in skeletal muscle sodium channels is deactivation. Cellular and Molecular Neurobiology. 20: 521-7. PMID 10901271 DOI: 10.1023/A:1007040731407  1
1999 Vilin YY, Makita N, George AL, Ruben PC. Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels. Biophysical Journal. 77: 1384-93. PMID 10465750 DOI: 10.1016/S0006-3495(99)76987-0  1
1999 Wang DW, VanDeCarr D, Ruben PC, George AL, Bennett PB. Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia. Febs Letters. 448: 231-4. PMID 10218481 DOI: 10.1016/S0014-5793(99)00338-5  1
1999 Groome JR, Fujimoto E, George AL, Ruben PC. Differential effects of homologous S4 mutations in human skeletal muscle sodium channels on deactivation gating from open and inactivated states. The Journal of Physiology. 516: 687-98. PMID 10200418 DOI: 10.1111/j.1469-7793.1999.0687u.x  1
1999 Cha A, Ruben PC, George AL, Fujimoto E, Bezanilla F. Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation. Neuron. 22: 73-87. PMID 10027291 DOI: 10.1016/S0896-6273(00)80680-7  1
1998 Richmond JE, Featherstone DE, Hartmann HA, Ruben PC. Slow inactivation in human cardiac sodium channels. Biophysical Journal. 74: 2945-52. PMID 9635748 DOI: 10.1016/S0006-3495(98)78001-4  1
1998 Featherstone DE, Fujimoto E, Ruben PC. A defect in skeletal muscle sodium channel deactivation exacerbates hyperexcitability in human paramyotonia congenita. The Journal of Physiology. 506: 627-38. PMID 9503326 DOI: 10.1111/j.1469-7793.1998.627bv.x  1
1997 Richmond JE, VanDeCarr D, Featherstone DE, George AL, Ruben PC. Defective fast inactivation recovery and deactivation account for sodium channel myotonia in the I1160V mutant. Biophysical Journal. 73: 1896-903. PMID 9336185 DOI: 10.1016/S0006-3495(97)78220-1  1
1997 Ruben PC, Fleig A, Featherstone D, Starkus JG, Rayner MD. Effects of clamp rise-time on rat brain IIA sodium channels in Xenopus oocytes. Journal of Neuroscience Methods. 73: 113-22. PMID 9196281 DOI: 10.1016/S0165-0270(96)02216-9  1
1997 Richmond JE, Featherstone DE, Ruben PC. Human Na+ channel fast and slow inactivation in paramyotonia congenita mutants expressed in Xenopus laevis oocytes. The Journal of Physiology. 499: 589-600. PMID 9130156 DOI: 10.1113/jphysiol.1997.sp021952  1
1996 Featherstone DE, Richmond JE, Ruben PC. Interaction between fast and slow inactivation in Skm1 sodium channels. Biophysical Journal. 71: 3098-109. PMID 8968581 DOI: 10.1016/S0006-3495(96)79504-8  1
1994 Fleig A, Fitch JM, Goldin AL, Rayner MD, Starkus JG, Ruben PC. Point mutations in IIS4 alter activation and inactivation of rat brain IIA Na channels in Xenopus oocyte macropatches. PflüGers Archiv : European Journal of Physiology. 427: 406-13. PMID 7971139 DOI: 10.1007/BF00374254  1
1994 Fleig A, Ruben PC, Rayner MD. Kinetic mode switch of rat brain IIA Na channels in Xenopus oocytes excised macropatches. PflüGers Archiv : European Journal of Physiology. 427: 399-405. PMID 7971138 DOI: 10.1007/BF00374253  1
1993 Starkus JG, Rayner MD, Fleig A, Ruben PC. Fast and slow inactivation of sodium channels: effects of photodynamic modification by methylene blue. Biophysical Journal. 65: 715-26. PMID 8218899 DOI: 10.1016/S0006-3495(93)81098-1  1
1992 Ruben PC, Starkus JG, Rayner MD. Steady-state availability of sodium channels. Interactions between activation and slow inactivation. Biophysical Journal. 61: 941-55. PMID 1316183 DOI: 10.1016/S0006-3495(92)81901-X  1
1992 Rayner MD, Starkus JG, Ruben PC, Alicata DA. Voltage-sensitive and solvent-sensitive processes in ion channel gating. Kinetic effects of hyperosmolar media on activation and deactivation of sodium channels. Biophysical Journal. 61: 96-108. PMID 1311613 DOI: 10.1016/S0006-3495(92)81819-2  1
1990 Ruben PC, Starkus JG, Rayner MD. Holding potential affects the apparent voltage-sensitivity of sodium channel activation in crayfish giant axons. Biophysical Journal. 58: 1169-81. PMID 1963328 DOI: 10.1016/S0006-3495(90)82458-9  1
1990 Stuenkel EL, Ruben P, Cooke IM, Lemos JR. Sodium-activated cation channels in peptidergic nerve terminals. Brain Research. 517: 35-43. PMID 1695866 DOI: 10.1016/0006-8993(90)91004-Z  1
1989 Cooke I, Graf R, Grau S, Haylett B, Meyers D, Ruben P. Crustacean peptidergic neurons in culture show immediate outgrowth in simple medium. Proceedings of the National Academy of Sciences of the United States of America. 86: 402-6. PMID 2643105  1
1984 Ruben P, Thompson S. Rapid recovery from K current inactivation on membrane hyperpolarization in molluscan neurons Journal of General Physiology. 84: 861-875. PMID 6097637 DOI: 10.1085/JGP.84.6.861  0.64
1983 Ruben P, Lukowiak K. Modulation of the Aplysia gill withdrawal reflex by dopamine. Journal of Neurobiology. 14: 271-84. PMID 6310047 DOI: 10.1002/neu.480140403  0.76
1981 Ruben P, Goldberg J, Edstrom J, Voshart K, Lukowiak K. Viewpoint. What the marine mollusc Aplysia can tell the neurologist about behavioral neurophysiology. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 8: 275-80. PMID 7326606 DOI: 10.1017/S0317167100043389  0.64
1979 Ruben P, Lukowiak K. Dopamine modulation of gill reflex behavior in Aplysia. Canadian Journal of Physiology and Pharmacology. 57: 329-32. PMID 445234 DOI: 10.1139/Y79-051  0.76
1979 Ruben PC, Swann JW, Carpenter DO. Neurotransmitter receptors on gill muscle fibers and the gill peripheral nerve plexus in Aplysia. Canadian Journal of Physiology and Pharmacology. 57: 1088-97. PMID 41632  0.64
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