| Year |
Citation |
Score |
| 2021 |
Genç B, Jara JH, Sanchez SS, Lagrimas AKB, Gözütok Ö, Koçak N, Zhu Y, Hande Özdinler P. Upper motor neurons are a target for gene therapy and UCHL1 is necessary and sufficient to improve cellular integrity of diseased upper motor neurons. Gene Therapy. PMID 34853443 DOI: 10.1038/s41434-021-00303-4 |
0.518 |
|
| 2020 |
Jara JH, Sheets PL, Nigro MJ, Perić M, Brooks C, Heller DB, Martina M, Andjus PR, Ozdinler PH. The Electrophysiological Determinants of Corticospinal Motor Neuron Vulnerability in ALS. Frontiers in Molecular Neuroscience. 13: 73. PMID 32508590 DOI: 10.3389/Fnmol.2020.00073 |
0.554 |
|
| 2019 |
Jara JH, Gautam M, Kocak N, Xie EF, Mao Q, Bigio EH, Özdinler PH. MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology. Journal of Neuroinflammation. 16: 196. PMID 31666087 DOI: 10.1186/S12974-019-1589-Y |
0.479 |
|
| 2018 |
Gautam M, Jara JH, Kocak N, Rylaarsdam LE, Kim KD, Bigio EH, Hande Özdinler P. Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology. Acta Neuropathologica. PMID 30450515 DOI: 10.1007/S00401-018-1934-8 |
0.466 |
|
| 2017 |
Jara JH, Genç B, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Özdinler PH. Evidence for an early innate immune response in the motor cortex of ALS. Journal of Neuroinflammation. 14: 129. PMID 28651542 DOI: 10.1186/S12974-017-0896-4 |
0.399 |
|
| 2017 |
Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH. Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Scientific Reports. 7: 41765. PMID 28165465 DOI: 10.1038/Srep41765 |
0.414 |
|
| 2016 |
Genç B, Jara JH, Schultz MC, Manuel M, Stanford MJ, Gautam M, Klessner JL, Sekerkova G, Heller DB, Cox GA, Heckman CJ, DiDonato CJ, Özdinler PH. Absence of UCHL 1 function leads to selective motor neuropathy. Annals of Clinical and Translational Neurology. 3: 331-45. PMID 27231703 DOI: 10.1002/Acn3.298 |
0.508 |
|
| 2016 |
Gautam M, Jara JH, Sekerkova G, Yasvoina MV, Martina M, Özdinler PH. Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms. Human Molecular Genetics. PMID 26755825 DOI: 10.1093/Hmg/Ddv631 |
0.531 |
|
| 2015 |
Jara JH, Stanford MJ, Zhu Y, Tu M, Hauswirth WW, Bohn MC, DeVries SH, Özdinler PH. Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex. Gene Therapy. PMID 26704722 DOI: 10.1038/Gt.2015.112 |
0.566 |
|
| 2015 |
Jara JH, Genç B, Cox GA, Bohn MC, Roos RP, Macklis JD, Ulup?nar E, Özdinler PH. Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function. Cerebral Cortex (New York, N.Y. : 1991). PMID 25596590 DOI: 10.1093/Cercor/Bhu318 |
0.556 |
|
| 2014 |
Jara JH, Genç B, Klessner JL, Ozdinler PH. Retrograde labeling, transduction, and genetic targeting allow cellular analysis of corticospinal motor neurons: implications in health and disease. Frontiers in Neuroanatomy. 8: 16. PMID 24723858 DOI: 10.3389/Fnana.2014.00016 |
0.531 |
|
| 2013 |
Jara JH, Frank DD, Özdinler PH. Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1. Cell Biochemistry and Biophysics. 67: 45-53. PMID 23695785 DOI: 10.1007/S12013-013-9631-7 |
0.403 |
|
| 2013 |
Yasvoina MV, Genç B, Jara JH, Sheets PL, Quinlan KA, Milosevic A, Shepherd GM, Heckman CJ, Özdinler PH. eGFP expression under UCHL1 promoter genetically labels corticospinal motor neurons and a subpopulation of degeneration-resistant spinal motor neurons in an ALS mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7890-904. PMID 23637180 DOI: 10.1523/Jneurosci.2787-12.2013 |
0.546 |
|
| 2012 |
Jara JH, Villa SR, Khan NA, Bohn MC, Ozdinler PH. AAV2 mediated retrograde transduction of corticospinal motor neurons reveals initial and selective apical dendrite degeneration in ALS. Neurobiology of Disease. 47: 174-83. PMID 22521461 DOI: 10.1016/J.Nbd.2012.03.036 |
0.577 |
|
| 2007 |
Jara JH, Singh BB, Floden AM, Combs CK. Tumor necrosis factor alpha stimulates NMDA receptor activity in mouse cortical neurons resulting in ERK-dependent death. Journal of Neurochemistry. 100: 1407-20. PMID 17241124 DOI: 10.1111/J.1471-4159.2006.04330.X |
0.442 |
|
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