Yasuo Ihara, MD - Publications

Affiliations: 
Neuropathology University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=59
Website:
http://books.google.com/books?id=QPqCvP0wFjUC&pg=PA209&lpg=PA209&dq=Yasuo+Ihara+tokyo&source=bl&ots=pitZ1PpZ6j&sig=DXK34KdhupZLLkBcCLSrRVGltd8&hl=en&ei=5XNCTfX4HcP78Aai0cyLAg&sa=X&oi=

126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, ... Ihara Y, et al. Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31235644 DOI: 10.1523/JNEUROSCI.2845-18.2019  0.48
2018 Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T. Distribution of endogenous normal tau in the mouse brain. The Journal of Comparative Neurology. PMID 30408165 DOI: 10.1002/cne.24577  0.48
2014 Miyashita A, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kitamura N, Akazawa K, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T, et al. Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. Translational Psychiatry. 4: e396. PMID 26126179 DOI: 10.1038/tp.2014.35  0.6
2014 Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. Journal of Neuropathology and Experimental Neurology. 73: 714-28. PMID 24918637 DOI: 10.1097/NEN.0000000000000087  0.6
2014 Miyashita A, Wen Y, Kitamura N, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Furukawa K, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, ... ... Ihara Y, et al. Lack of genetic association between TREM2 and late-onset Alzheimer's disease in a Japanese population. Journal of Alzheimer's Disease : Jad. 41: 1031-8. PMID 24762945 DOI: 10.3233/JAD-140225  0.44
2014 Xie C, Miyasaka T, Yoshimura S, Hatsuta H, Yoshina S, Kage-Nakadai E, Mitani S, Murayama S, Ihara Y. The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. Plos One. 9: e89796. PMID 24587039 DOI: 10.1371/journal.pone.0089796  0.6
2014 Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M. γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. The Journal of Biological Chemistry. 289: 5109-21. PMID 24375443 DOI: 10.1074/jbc.M113.510131  0.6
2014 Okumura JE, Ihara Y, Doi M, Morokuma T, Pain R, Totani T, Barbary K, Takanashi N, Yasuda N, Aldering G, Dawson K, Goldhaber G, Hook I, Lidman C, Perlmutter S, et al. The type Ia supernovae rate with Subaru/XMM-Newton deep survey Publications of the Astronomical Society of Japan. 66. DOI: 10.1093/pasj/psu024  0.48
2013 Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nature Communications. 4: 2529. PMID 24108142 DOI: 10.1038/ncomms3529  0.6
2013 Kang MS, Baek SH, Chun YS, Moore AZ, Landman N, Berman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S, Kim TW. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. The Journal of Biological Chemistry. 288: 20868-82. PMID 23723072 DOI: 10.1074/jbc.M112.445734  0.6
2013 Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, ... ... Ihara Y, et al. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. Plos One. 8: e58618. PMID 23565137 DOI: 10.1371/journal.pone.0058618  0.6
2013 Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Akatsu H, Yamamoto T, Kosaka K, Yamaguchi H, Akazawa K, Ihara Y, et al. SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 35: 387-94. PMID 23455993 DOI: 10.3233/JAD-122395  0.6
2013 Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Reports. 3: 42-51. PMID 23291095 DOI: 10.1016/j.celrep.2012.11.028  0.6
2013 Kakuda N, Akazawa K, Hatsuta H, Murayama S, Ihara Y. Suspected limited efficacy of γ-secretase modulators. Neurobiology of Aging. 34: 1101-4. PMID 23058852 DOI: 10.1016/j.neurobiolaging.2012.08.017  0.6
2012 Ihara Y, Morishima-Kawashima M, Nixon R. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908190 DOI: 10.1101/cshperspect.a006361  0.6
2012 Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, ... ... Ihara Y, et al. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. Embo Molecular Medicine. 4: 344-52. PMID 22354516 DOI: 10.1002/emmm.201200214  0.6
2012 Meyers J, Aldering G, Barbary K, Barrientos LF, Brodwin M, Dawson KS, Deustua S, Doi M, Eisenhardt P, Faccioli L, Fakhouri HK, Fruchter AS, Gilbank DG, Gladders MD, Goldhaber G, ... ... Ihara Y, et al. The Hubble Space Telescope cluster supernova survey. III. Correlated properties of TYPEIa supernovae and their hosts at 0.9 < z < 1.46 Astrophysical Journal. 750. DOI: 10.1088/0004-637X/750/1/1  0.48
2012 Suzuki N, Rubin D, Lidman C, Aldering G, Amanullah R, Barbary K, Barrientos LF, Botyanszki J, Brodwin M, Connolly N, Dawson KS, Dey A, Doi M, Donahue M, Deustua S, ... ... Ihara Y, et al. The Hubble Space Telescope Cluster Supernova Survey. V. Improving the dark-energy constraints above z > 1 and building an early-type-hosted supernova sample Astrophysical Journal. 746. DOI: 10.1088/0004-637X/746/1/85  0.48
2012 Barbary K, Aldering G, Amanullah R, Brodwin M, Connolly N, Dawson KS, Doi M, Eisenhardt P, Faccioli L, Fadeyev V, Fakhouri HK, Fruchter AS, Gilbank DG, Gladders MD, Goldhaber G, ... ... Ihara Y, et al. The Hubble space telescope cluster supernova survey. VI. the volumetric type Ia supernova rate in high-redshift galaxy clusters Astrophysical Journal. 745. DOI: 10.1088/0004-637X/745/1/31  0.48
2011 Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Potent amyloidogenicity and pathogenicity of Aβ43. Nature Neuroscience. 14: 1023-32. PMID 21725313 DOI: 10.1038/nn.2858  0.6
2011 Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, Yamamoto M. Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 16: 692-703. PMID 21554501 DOI: 10.1111/j.1365-2443.2011.01522.x  0.6
2011 Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E. Dissociation of β-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β-amyloid-42 assembly. Journal of Neuroscience Research. 89: 815-21. PMID 21394760 DOI: 10.1002/jnr.22615  0.6
2010 Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, et al. The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society. 10: 117-23. PMID 20860566 DOI: 10.1111/j.1479-8301.2010.00330.x  0.6
2010 Morokuma T, Tokita K, Lidman C, Doi M, Yasuda N, Aldering G, Amanullah R, Barbary K, Dawson K, Fadeyev V, Fakhouri HK, Goldhaber G, Goobar A, Hattori T, Hayano J, ... ... Ihara Y, et al. Subaru FOCAS spectroscopic observations of high-redshift supernovae Publications of the Astronomical Society of Japan. 62: 19-37.  0.48
2009 Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13042-52. PMID 19828817 DOI: 10.1523/JNEUROSCI.2362-09.2009  0.6
2009 Chae YC, Lee S, Heo K, Ha SH, Jung Y, Kim JH, Ihara Y, Suh PG, Ryu SH. Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity. Cellular Signalling. 21: 1818-26. PMID 19666111 DOI: 10.1016/j.cellsig.2009.07.017  0.6
2009 Takei N, Miyashita A, Tsukie T, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kimura H, Kakita A, Takahashi H, Tsuji S, Kanazawa I, Ihara Y, et al. Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese. Genomics. 93: 441-8. PMID 19442637 DOI: 10.1016/j.ygeno.2009.01.003  0.6
2009 Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R. GAB2 is not associated with late-onset Alzheimer's disease in Japanese. European Journal of Human Genetics : Ejhg. 17: 682-6. PMID 18854865 DOI: 10.1038/ejhg.2008.181  0.6
2009 Dawson KS, Aldering G, Amanullah R, Barbary K, Barrientos LF, Brodwin M, Connolly N, Dey A, Doi M, Donahue M, Eisenhardt P, Ellingson E, Faccioli L, Fadeyev V, Fakhouri HK, ... ... Ihara Y, et al. An intensive hubble space telescope survey for z>1 type Ia supernovae by targeting galaxy clusters Astronomical Journal. 138: 1271-1283. DOI: 10.1088/0004-6256/138/5/1271  0.48
2009 Ihara Y, Doi M, Morokuma T, Pain R, Takanashi N, Yasuda N, Aldering G, Dawson K, Goldhaber G, Hook I, Lidman C, Perlmutter S, Spadafora A, Suzuki N, Wang L. A rate study of Type Ia supernovae with Subaru/XMM-Newton Deep Survey Proceedings of the International Astronomical Union. 5: 358-361. DOI: 10.1017/S1743921310003224  0.48
2008 Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y. Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. The Journal of Biological Chemistry. 283: 19283-92. PMID 18480063 DOI: 10.1074/jbc.M705954200  0.6
2008 Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta. The Journal of Biological Chemistry. 283: 16488-96. PMID 18430735 DOI: 10.1074/jbc.M801279200  0.6
2008 Yagishita S, Morishima-Kawashima M, Ishiura S, Ihara Y. Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. The Journal of Biological Chemistry. 283: 733-8. PMID 18024430 DOI: 10.1074/jbc.M707103200  0.6
2007 Ihara Y. [Overview on Alzheimer's disease]. Rinshō Shinkeigaku = Clinical Neurology. 47: 902-4. PMID 18210830  0.6
2007 Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/jbc.M705248200  0.6
2007 Miyashita A, Arai H, Asada T, Imagawa M, Matsubara E, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, Kuwano R, et al. Genetic association of CTNNA3 with late-onset Alzheimer's disease in females. Human Molecular Genetics. 16: 2854-69. PMID 17761686 DOI: 10.1093/hmg/ddm244  0.6
2007 Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, Ihara Y. Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. Journal of Neurochemistry. 101: 949-58. PMID 17472586 DOI: 10.1111/j.1471-4159.2006.04400.x  0.6
2007 Ihara Y. Overview Clinical Neurology. 47: 902-904.  0.6
2006 Ihara Y. Neurofibrillary tangles/paired helical filaments (1981-83). Journal of Alzheimer's Disease : Jad. 9: 209-17. PMID 16914860  0.6
2006 Iwatsubo T, Ihara Y, Kanazawa I. Alzheimer disease research in Japan: public funding. Nature Medicine. 12: 778-9. PMID 16829946 DOI: 10.1038/nm0706-778  0.6
2006 Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, et al. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Human Molecular Genetics. 15: 2170-82. PMID 16740596 DOI: 10.1093/hmg/ddl142  0.6
2006 Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. The Journal of Biological Chemistry. 281: 14776-86. PMID 16595682 DOI: 10.1074/jbc.M513453200  0.6
2006 Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y. DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry. 45: 3952-60. PMID 16548522 DOI: 10.1021/bi0521846  0.6
2005 Miyasaka T, Ding Z, Gengyo-Ando K, Oue M, Yamaguchi H, Mitani S, Ihara Y. Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiology of Disease. 20: 372-83. PMID 16242642 DOI: 10.1016/j.nbd.2005.03.017  0.6
2005 Miyasaka T, Watanabe A, Saito Y, Murayama S, Mann DM, Yamazaki M, Ravid R, Morishima-Kawashima M, Nagashima K, Ihara Y. Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. Journal of Neuropathology and Experimental Neurology. 64: 665-74. PMID 16106214  0.6
2005 Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. Febs Letters. 579: 2907-12. PMID 15890346 DOI: 10.1016/j.febslet.2005.04.037  0.6
2005 Shoji M, Kuwano R, Asada T, Imagawa M, Higuchi S, Urakami K, Arai H, Ihara Y. [A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease]. Rinshō Shinkeigaku = Clinical Neurology. 45: 128-37. PMID 15782613  0.6
2005 Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. The Journal of Biological Chemistry. 280: 19070-7. PMID 15764596 DOI: 10.1074/jbc.M501130200  0.6
2005 Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y. Independent accumulations of tau and amyloid beta-protein in the human entorhinal cortex. Neurology. 64: 687-92. PMID 15728293 DOI: 10.1212/01.WNL.0000151958.79884.86  0.6
2005 Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura Y, Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Murayama S, Kohriyama T, Katayama S, Yamashita M, Yamamoto T, ... ... Ihara Y, et al. Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease. Neurology. 64: 643-8. PMID 15728285 DOI: 10.1212/01.WNL.0000151847.57956.FA  0.48
2005 Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y. Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 165-79. PMID 15676027 DOI: 10.1111/j.1365-2443.2005.00827.x  0.6
2005 Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 436-45. PMID 15647487 DOI: 10.1523/JNEUROSCI.1575-04.2005  0.6
2004 Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry. 43: 13532-40. PMID 15491160 DOI: 10.1021/bi049399k  0.6
2004 Watanabe A, Hong WK, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y. Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. Journal of Neurochemistry. 90: 1302-11. PMID 15341514 DOI: 10.1111/j.1471-4159.2004.02611.x  0.6
2004 Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. The Journal of Biological Chemistry. 279: 27272-7. PMID 15087445 DOI: 10.1074/jbc.M401634200  0.6
2004 Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1013-5. PMID 15084524 DOI: 10.1096/fj.03-1040fje  0.6
2003 Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y. Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry. 42: 13977-86. PMID 14636066 DOI: 10.1021/bi034904j  0.6
2003 Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S. Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. The Embo Journal. 22: 2913-23. PMID 12805207 DOI: 10.1093/emboj/cdg299  0.6
2003 Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/jbc.M211161200  0.6
2003 Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry. 42: 1042-52. PMID 12549925 DOI: 10.1021/bi0267590  0.6
2002 Morishima-Kawashima M, Ihara Y. Alzheimer's disease: beta-Amyloid protein and tau. Journal of Neuroscience Research. 70: 392-401. PMID 12391602 DOI: 10.1002/jnr.10355  0.6
2002 Ihara Y. [gamma secretase]. Seikagaku. the Journal of Japanese Biochemical Society. 74: 449-54. PMID 12138705  0.6
2002 Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH. Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. The Journal of Biological Chemistry. 277: 6542-9. PMID 11741937 DOI: 10.1074/jbc.M108047200  0.6
2001 Morishima-Kawashima M, Ihara Y. [Recent advances in Alzheimer's disease]. Seikagaku. the Journal of Japanese Biochemical Society. 73: 1297-307. PMID 11831025  0.6
2001 Utsunomiya I, Ren J, Taguchi K, Ariga T, Tai T, Ihara Y, Miyatake T. Immunohistochemical detection of verotoxin receptors in nervous system. Brain Research. Brain Research Protocols. 8: 99-103. PMID 11673091 DOI: 10.1016/S1385-299X(01)00091-5  0.6
2001 Morishima-Kawashima M, Saido TC, Ihara Y. [Alzheimer's disease and the proteins]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 46: 1798-804. PMID 11579581  0.6
2001 Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima K, Ihara Y. Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation. Journal of Neuropathology and Experimental Neurology. 60: 872-84. PMID 11556544  0.6
2001 Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. The Journal of Biological Chemistry. 276: 35235-8. PMID 11483588 DOI: 10.1074/jbc.C100357200  0.6
2001 Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. Journal of Neuropathology and Experimental Neurology. 60: 731-9. PMID 11444802  0.6
2001 Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y. Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. The American Journal of Pathology. 158: 2209-18. PMID 11395399  0.6
2001 Shimada H, Kasakura S, Shiotani M, Nakamura K, Ikeuchi M, Hoshino T, Komatsu T, Ihara Y, Sohma M, Maeda Y, Matsuura R, Nakamura S, Hine C, Ohkura N, Kato H. Hypocoagulable state of human preovulatory ovarian follicular fluid: role of sulfated proteoglycan and tissue factor pathway inhibitor in the fluid. Biology of Reproduction. 64: 1739-45. PMID 11369603  0.32
2001 Ihara Y. PHF and PHF-like fibrils--cause or consequence? Neurobiology of Aging. 22: 123-6. PMID 11164285 DOI: 10.1016/S0197-4580(00)00200-1  0.6
2001 Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y. Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. The American Journal of Pathology. 158: 373-9. PMID 11159174 DOI: 10.1016/S0002-9440(10)63979-X  0.6
2001 Yamazaki T, Chang TY, Haass C, Ihara Y. Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. The Journal of Biological Chemistry. 276: 4454-60. PMID 11085995 DOI: 10.1074/jbc.M009598200  0.6
2000 Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, Ihara Y. Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain. The American Journal of Pathology. 157: 2093-9. PMID 11106581  0.6
2000 Saito Y, Kawai M, Inoue K, Sasaki R, Arai H, Nanba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S. Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. Journal of the Neurological Sciences. 177: 48-59. PMID 10967182 DOI: 10.1016/S0022-510X(00)00337-3  0.6
2000 Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. The Journal of Biological Chemistry. 275: 27901-8. PMID 10846187 DOI: 10.1074/jbc.M004308200  0.6
2000 Misonou H, Morishima-Kawashima M, Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry. 39: 6951-9. PMID 10841777 DOI: 10.1021/bi000169p  0.6
2000 Gu Y, Ihara Y. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. The Journal of Biological Chemistry. 275: 17917-20. PMID 10770920 DOI: 10.1074/jbc.C000179200  0.6
2000 Gu Y, Hamajima N, Ihara Y. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry. 39: 4267-75. PMID 10757975 DOI: 10.1021/bi992323h  0.6
1999 Kokubo Y, Kuzuhara S, Narita Y, Kikugawa K, Nakano R, Inuzuka T, Tsuji S, Watanabe M, Miyazaki T, Murayama S, Ihara Y. Accumulation of neurofilaments and SOD1-immunoreactive products in a patient with familial amyotrophic lateral sclerosis with I113T SOD1 mutation. Archives of Neurology. 56: 1506-8. PMID 10593307  0.6
1999 Funato H, Enya M, Yoshimura M, Morishima-Kawashima M, Ihara Y. Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation. The American Journal of Pathology. 155: 23-8. PMID 10393832  0.6
1999 Matsumura N, Yamazaki T, Ihara Y. Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). The American Journal of Pathology. 154: 1649-56. PMID 10362789 DOI: 10.1016/S0002-9440(10)65420-X  0.6
1999 Ren J, Utsunomiya I, Taguchi K, Ariga T, Tai T, Ihara Y, Miyatake T. Localization of verotoxin receptors in nervous system. Brain Research. 825: 183-8. PMID 10216186 DOI: 10.1016/S0006-8993(99)01196-8  0.6
1999 Watanabe A, Takio K, Ihara Y. Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. The Journal of Biological Chemistry. 274: 7368-78. PMID 10066801 DOI: 10.1074/jbc.274.11.7368  0.6
1999 Enya M, Morishima-Kawashima M, Yoshimura M, Shinkai Y, Kusui K, Khan K, Games D, Schenk D, Sugihara S, Yamaguchi H, Ihara Y. Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging. The American Journal of Pathology. 154: 271-9. PMID 9916941  0.6
1998 Gu YJ, Oyama F, Ihara Y. Simultaneous quantification of APP and tau mRNA by RT-PCR. Shi Yan Sheng Wu Xue Bao. 31: 1-6. PMID 12014106  0.6
1998 Morishima-Kawashima M, Ihara Y. The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells. Biochemistry. 37: 15247-53. PMID 9799484 DOI: 10.1021/bi981843u  0.6
1998 Oyama F, Murakami N, Ihara Y. Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease. Neuroscience Research. 31: 1-8. PMID 9704973 DOI: 10.1016/S0168-0102(98)00020-0  0.6
1998 Murakami N, Oyama F, Gu Y, McLennan IS, Nonaka I, Ihara Y. Accumulation of tau in autophagic vacuoles in chloroquine myopathy. Journal of Neuropathology and Experimental Neurology. 57: 664-73. PMID 9690670  0.6
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, ... Ihara Y, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880  0.6
1998 Funato H, Yoshimura M, Kusui K, Tamaoka A, Ishikawa K, Ohkoshi N, Namekata K, Okeda R, Ihara Y. Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. The American Journal of Pathology. 152: 1633-40. PMID 9626067  0.6
1998 Nakabayashi J, Yoshimura M, Morishima-Kawashima M, Funato H, Miyakawa T, Yamazaki T, Ihara Y. Amyloid beta-protein (A beta) accumulation in the putamen and mammillary body during aging and in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 57: 343-52. PMID 9600228  0.6
1998 Yamazaki T, Ihara Y. Effects of specific protease inhibitors on amyloid β-protein 42 secretion Neurobiology of Aging. 19: S77-S79. PMID 9562473 DOI: 10.1016/S0197-4580(98)00031-1  0.6
1998 Yanagisawa K, Ihara Y. GM1 ganglioside-bound amyloid β-protein in Alzheimer's disease brain Neurobiology of Aging. 19: S65-S67. PMID 9562471 DOI: 10.1016/S0197-4580(98)00032-3  0.6
1998 Davies P, Resnick J, Resnick B, Gilman S, Growdon JH, Khachaturian ZS, Radebaugh TS, Roses AD, Selkoe DJ, Trojanowski JQ, Blass JP, Gibson GE, Sheu KFR, Blennow K, Delacourte A, ... ... Ihara Y, et al. Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' Neurobiology of Aging. 19: 109-116. PMID 9558143 DOI: 10.1016/S0197-4580(98)00022-0  0.6
1998 Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. The American Journal of Pathology. 152: 983-92. PMID 9546359  0.6
1998 Yoshida H, Watanabe A, Ihara Y. Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. The Journal of Biological Chemistry. 273: 9761-8. PMID 9545313 DOI: 10.1074/jbc.273.16.9761  0.6
1998 Yamaguchi H, Sugihara S, Ogawa A, Saido TC, Ihara Y. Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques. Acta Neuropathologica. 95: 217-22. PMID 9542585 DOI: 10.1007/s004010050790  0.6
1997 Ihara Y. β-amyloidogenesis Clinical Neurology. 37: 1100-1101. PMID 9577656  0.6
1997 Yanagisawa K, McLaurin J, Michikawa M, Chakrabartty A, Ihara Y. Amyloid β-protein (Aβ) associated with lipid molecules: Immunoreactivity distinct from that of soluble Aβ Febs Letters. 420: 43-46. PMID 9450547 DOI: 10.1016/S0014-5793(97)01484-1  0.6
1997 Shinkai Y, Yoshimura M, Morishima-Kawashima M, Ito Y, Shimada H, Yanagisawa K, Ihara Y. Amyloid β-protein deposition in the leptomeninges and cerebral cortex Annals of Neurology. 42: 899-908. PMID 9403483 DOI: 10.1002/ana.410420612  0.6
1997 Namekata K, Imagawa M, Terashi A, Ohta S, Oyama F, Ihara Y. Association of transferrin C2 allele with late-onset Alzheimer's disease Human Genetics. 101: 126-129. PMID 9402955 DOI: 10.1007/s004390050600  0.6
1997 Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport. 8: 2797-801. PMID 9295120  0.6
1997 Namekata K, Oyama F, Imagawa M, Ihara Y. Human transferrin (Tf): A single mutation at codon 570 determines Tf C1 or Tf C2 variant Human Genetics. 100: 457-458. PMID 9272172 DOI: 10.1007/s004390050533  0.6
1997 Hamano T, Yoshimura M, Yamazaki T, Shinkai Y, Yanagisawa K, Kuriyama M, Ihara Y. Amyloid β-protein (Aβ) accumulation in the leptomeninges during aging and in Alzheimer disease Journal of Neuropathology and Experimental Neurology. 56: 922-932. PMID 9258262  0.6
1997 Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/bi970209y  0.6
1997 Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C. Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. The Journal of Biological Chemistry. 272: 16085-8. PMID 9195901 DOI: 10.1074/jbc.272.26.16085  0.6
1997 Yamazaki T, Ihara Y. Molecular pathology of Alzheimer's disease Neuropathology. 17: 263-269.  0.6
1997 Gu Y, Ma J, Oyama F, Ihara Y. Strong induction of apolipoprotein E expression in rat muscle by chronic intoxication with chloroquine Progress in Biochemistry and Biophysics. 24: 44-48.  0.6
1996 Kanemaru K, Iwatsubo T, Ihara Y. Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain. Neuroscience Letters. 214: 196-8. PMID 8878117  0.56
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Lewy bodies: purification from diffuse Lewy body disease brains. Annals of the New York Academy of Sciences. 786: 195-205. PMID 8687019  0.56
1996 Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman ML, Rossor MN. Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. The American Journal of Pathology. 148: 1257-66. PMID 8644866  0.56
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. The American Journal of Pathology. 148: 1517-29. PMID 8623921  0.56
1996 Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T. Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. The American Journal of Pathology. 148: 259-65. PMID 8546214  0.56
1995 Mann DM, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathologica. 90: 472-7. PMID 8560980  0.56
1995 Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron. 14: 457-66. PMID 7857653  0.56
1995 Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Annals of Neurology. 37: 294-9. PMID 7695229 DOI: 10.1002/ana.410370305  0.56
1995 Mann DM, Pickering-Brown SM, Siddons MA, Iwatsubo T, Ihara Y, Asami-Odaka A, Suzuki N. The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype. Neuroscience Letters. 196: 105-8. PMID 7501233  0.56
1994 Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y. High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. The American Journal of Pathology. 145: 452-60. PMID 8053502  0.56
1994 Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13: 45-53. PMID 8043280 DOI: 10.1016/0896-6273(94)90458-8  0.6
1994 Iwatsubo T, Hasegawa M, Ihara Y. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathologica. 88: 129-36. PMID 7985493  0.56
1992 Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y. Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. The American Journal of Pathology. 140: 277-82. PMID 1310831  0.56
1983 Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 304: 727-30. PMID 6350889  0.64
1982 Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proceedings of the National Academy of Sciences of the United States of America. 79: 6070-4. PMID 6136967  0.64
1982 Selkoe DJ, Ihara Y, Salazar FJ. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (New York, N.Y.). 215: 1243-5. PMID 6120571  0.64
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