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Dennis J. Selkoe, MD - Publications

Neurology Harvard Medical School, Boston, MA, United States 

330 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, Arora R, Zeng A, Xu P, Qu S, Krichevsky AM, Selkoe DJ, Li S. Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways. Neurobiology of Disease. 104617. PMID 31669733 DOI: 10.1016/j.nbd.2019.104617  0.48
2019 Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31416794 DOI: 10.1016/j.jalz.2019.06.3918  0.48
2019 Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF. Annals of Neurology. PMID 31168802 DOI: 10.1002/ana.25513  0.88
2019 Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain. Brain : a Journal of Neurology. 142: 1441-1457. PMID 31032851 DOI: 10.1093/brain/awz066  0.88
2019 Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. The Journal of Cell Biology. PMID 30626721 DOI: 10.1083/jcb.201806205  0.48
2018 Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30419228 DOI: 10.1016/j.jalz.2018.09.010  0.88
2018 Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathologica Communications. 6: 121. PMID 30409172 DOI: 10.1186/s40478-018-0626-x  0.56
2018 Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease. Nature Communications. 9: 2676. PMID 29992960 DOI: 10.1038/s41467-018-05068-w  0.88
2018 El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathologica. PMID 29982852 DOI: 10.1007/s00401-018-1880-5  0.88
2018 Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International Journal of Molecular Sciences. 19. PMID 29495441 DOI: 10.3390/ijms19030663  0.88
2017 Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, ... ... Selkoe DJ, et al. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. PMID 29153990 DOI: 10.1016/j.stemcr.2017.10.015  1
2017 Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, ... ... Selkoe DJ, et al. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science (New York, N.Y.). 357: 891-898. PMID 28860381 DOI: 10.1126/science.aaf3934  0.52
2017 Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, et al. A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28734051 DOI: 10.1002/mds.27090  0.48
2017 Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Developmental Biology. PMID 28284905 DOI: 10.1016/j.ydbio.2017.03.007  1
2017 Bolduc DM, Selkoe DJ, Wolfe MS. Enzymatic Assays for Studying Intramembrane Proteolysis. Methods in Enzymology. 584: 295-308. PMID 28065268 DOI: 10.1016/bs.mie.2016.10.026  0.48
2017 Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 152-163. PMID 28053038 DOI: 10.1523/JNEUROSCI.1698-16.2017  0.88
2016 Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ. The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase. Elife. 5. PMID 27580372 DOI: 10.7554/eLife.17578  0.48
2016 Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones. Bioorganic & Medicinal Chemistry Letters. PMID 27038496 DOI: 10.1016/j.bmcl.2016.03.077  1
2016 Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science (New York, N.Y.). PMID 27033548 DOI: 10.1126/science.aad8373  1
2016 Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols. Bioorganic & Medicinal Chemistry Letters. PMID 27020305 DOI: 10.1016/j.bmcl.2016.03.042  1
2016 Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27013392 DOI: 10.1016/j.bmcl.2016.03.040  1
2016 Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Reviews. Neuroscience. 17: 251-60. PMID 26988744 DOI: 10.1038/nrn.2016.13  0.88
2016 Selkoe DJ, Weinberger DR. Editorial overview: Neurobiology of disease. Current Opinion in Neurobiology. PMID 26797413 DOI: 10.1016/j.conb.2016.01.001  1
2015 Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS. Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699478 DOI: 10.1073/pnas.1512952113  1
2015 Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. The Journal of Cell Biology. 211: 1157-76. PMID 26694839 DOI: 10.1083/jcb.201502001  1
2015 Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J. A Fluorescent Analog of Batimastat Enables Imaging of α-Secretase in Living Cells. Acs Chemical Neuroscience. PMID 26559179 DOI: 10.1021/acschemneuro.5b00283  0.88
2015 Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiology of Disease. 85: 111-121. PMID 26525100 DOI: 10.1016/j.nbd.2015.10.019  0.88
2015 Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Reports. PMID 26299970 DOI: 10.1016/j.celrep.2015.07.061  0.4
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, ... Selkoe DJ, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/j.jalz.2015.06.1887  1
2015 Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10851-65. PMID 26224867 DOI: 10.1523/JNEUROSCI.0387-15.2015  1
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... Selkoe DJ, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a Journal of Neurology. 138: 2659-71. PMID 26220939 DOI: 10.1093/brain/awv202  0.8
2015 Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 9596-601. PMID 26153422 DOI: 10.1073/pnas.1505953112  1
2015 Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 7314. PMID 26076669 DOI: 10.1038/ncomms8314  1
2015 Jin M, Selkoe DJ. Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol. Neurobiology of Disease. 82: 152-163. PMID 26054438 DOI: 10.1016/j.nbd.2015.05.020  1
2015 Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/s13195-015-0100-y  1
2015 Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 54: 279-92. PMID 25490121 DOI: 10.1021/bi501188a  1
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... Selkoe DJ, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease Brain. 138: 2659-2671. DOI: 10.1093/brain/awv202  1
2014 Bartels T, Kim NC, Luth ES, Selkoe DJ. N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation. Plos One. 9: e103727. PMID 25075858 DOI: 10.1371/journal.pone.0103727  1
2014 Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. American Journal of Hematology. 89: 974-7. PMID 25043722 DOI: 10.1002/ajh.23796  0.84
2014 Wolfe MS, Selkoe DJ. γ-Secretase: a horseshoe structure brings good luck. Cell. 158: 247-9. PMID 25036627 DOI: 10.1016/j.cell.2014.06.043  1
2014 Luth ES, Stavrovskaya IG, Bartels T, Kristal BS, Selkoe DJ. Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction. The Journal of Biological Chemistry. 289: 21490-507. PMID 24942732 DOI: 10.1074/jbc.M113.545749  1
2014 Holmes O, Paturi S, Selkoe DJ, Wolfe MS. Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry. 53: 4393-406. PMID 24941111 DOI: 10.1021/bi500489j  1
2014 Holmes O, Paturi S, Wolfe MS, Selkoe DJ. Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies. Journal of Neurochemistry. 131: 94-100. PMID 24865334 DOI: 10.1111/jnc.12772  1
2014 Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 53: 3908-21. PMID 24840308 DOI: 10.1021/bi5003053  1
2014 Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron. 82: 308-19. PMID 24685176 DOI: 10.1016/j.neuron.2014.02.027  1
2014 Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics. 23: 3523-36. PMID 24524897 DOI: 10.1093/hmg/ddu064  1
2014 Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of α-synuclein Neurodegenerative Diseases. 13: 114-117. PMID 24192542 DOI: 10.1159/000355516  1
2013 Selkoe DJ. The therapeutics of Alzheimer's disease: where we stand and where we are heading. Annals of Neurology. 74: 328-36. PMID 25813842 DOI: 10.1002/ana.24001  1
2013 Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous α-synuclein. Plos One. 8: e81314. PMID 24278419 DOI: 10.1371/journal.pone.0081314  1
2013 Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, ... ... Selkoe DJ, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635  1
2013 Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, ... ... Selkoe DJ, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 81: 1531-7. PMID 24068787 DOI: 10.1212/WNL.0b013e3182a95818  1
2013 Selkoe DJ. SnapShot: pathobiology of Alzheimer's disease. Cell. 154: 468-468.e1. PMID 23870132 DOI: 10.1016/j.cell.2013.07.003  1
2013 Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 52: 3264-77. PMID 23597280 DOI: 10.1021/bi400165f  1
2013 Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia. 61: 985-1002. PMID 23536313 DOI: 10.1002/glia.22490  1
2013 Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron. 77: 929-41. PMID 23473322 DOI: 10.1016/j.neuron.2012.12.040  1
2013 Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 99-112. PMID 23375565 DOI: 10.1016/j.jalz.2012.11.005  1
2013 Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells. The Journal of Biological Chemistry. 288: 6371-85. PMID 23319586 DOI: 10.1074/jbc.M112.403311  1
2013 Bartels T, Selkoe DJ. Bartels & Selkoe reply Nature. 498: E6-E7. DOI: 10.1038/nature12126  1
2012 Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. Acs Chemical Neuroscience. 3: 941-51. PMID 23205187 DOI: 10.1021/cn3000857  1
2012 Holtzman DM, Mandelkow E, Selkoe DJ. Alzheimer disease in 2020. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23125202 DOI: 10.1101/cshperspect.a011585  1
2012 Selkoe DJ. Preventing Alzheimer's disease. Science (New York, N.Y.). 337: 1488-92. PMID 22997326 DOI: 10.1126/science.1228541  1
2012 Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development (Cambridge, England). 139: 3986-96. PMID 22992957 DOI: 10.1242/dev.082909  1
2012 Mucke L, Selkoe DJ. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harbor Perspectives in Medicine. 2: a006338. PMID 22762015 DOI: 10.1101/cshperspect.a006338  1
2012 Holmes O, Paturi S, Ye W, Wolfe MS, Selkoe DJ. Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry. 51: 3565-75. PMID 22489600 DOI: 10.1021/bi300303g  1
2012 Koyama A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F. Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Archives of Neurology. 69: 824-31. PMID 22451159 DOI: 10.1001/archneurol.2011.1841  1
2012 Selkoe D, Mandelkow E, Holtzman D. Deciphering Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a011460. PMID 22315723 DOI: 10.1101/cshperspect.a011460  1
2012 Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, ... ... Selkoe DJ, et al. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. 39: 209-19. PMID 22218879 DOI: 10.1007/s00259-011-2045-0  1
2012 Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, Selkoe DJ, Sharon R. Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathology (Zurich, Switzerland). 22: 280-94. PMID 21929559 DOI: 10.1111/j.1750-3639.2011.00530.x  1
2012 Townsend MK, Okereke OI, Xia W, Yang T, Selkoe DJ, Grodstein F. Relation between insulin, insulin-related factors, and plasma amyloid beta peptide levels at midlife in a population-based study. Alzheimer Disease and Associated Disorders. 26: 50-4. PMID 21502851 DOI: 10.1097/WAD.0b013e31821764ce  1
2012 Selkoe DJ, Morris JC. Ready for prime time Scientist. 26.  1
2011 Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Archives of Neurology. 68: 1385-92. PMID 22084122 DOI: 10.1001/archneurol.2011.242  1
2011 Morris JC, Selkoe DJ. Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview. Neurobiology of Aging. 32: S1-3. PMID 22078168 DOI: 10.1016/j.neurobiolaging.2011.09.005  1
2011 Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15861-9. PMID 22049429 DOI: 10.1523/JNEUROSCI.3272-11.2011  1
2011 Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Archives of Neurology. 68: 1239-44. PMID 21987540 DOI: 10.1001/archneurol.2011.203  1
2011 Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, ... ... Selkoe DJ, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2283-6. PMID 21953863 DOI: 10.1002/mds.23934  1
2011 Selkoe DJ. Resolving controversies on the path to Alzheimer's therapeutics. Nature Medicine. 17: 1060-5. PMID 21900936 DOI: 10.1038/nm.2460  1
2011 Bartels T, Choi JG, Selkoe DJ. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature. 477: 107-10. PMID 21841800 DOI: 10.1038/nature10324  1
2011 Selkoe DJ. Alzheimer's disease. Cold Spring Harbor Perspectives in Biology. 3. PMID 21576255 DOI: 10.1101/cshperspect.a004457  1
2011 Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6627-38. PMID 21543591 DOI: 10.1523/JNEUROSCI.0203-11.2011  1
2011 Okereke OI, Selkoe DJ, Grodstein F. Plasma beta-amyloid level, cognitive reserve, and cognitive decline. Jama. 305: 1655; author reply 1. PMID 21521843 DOI: 10.1001/jama.2011.524  1
2011 Meissner C, Lorenz H, Weihofen A, Selkoe DJ, Lemberg MK. The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking. Journal of Neurochemistry. 117: 856-67. PMID 21426348 DOI: 10.1111/j.1471-4159.2011.07253.x  0.88
2011 Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. 108: 5819-24. PMID 21421841 DOI: 10.1073/pnas.1017033108  1
2011 Davis RC, Marsden IT, Maloney MT, Minamide LS, Podlisny M, Selkoe DJ, Bamburg JR. Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Molecular Neurodegeneration. 6: 10. PMID 21261978 DOI: 10.1186/1750-1326-6-10  1
2011 Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain. Methods in Molecular Biology (Clifton, N.J.). 670: 33-44. PMID 20967581 DOI: 10.1007/978-1-60761-744-0_3  1
2011 Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of Aging. 32: 2211-8. PMID 20097446 DOI: 10.1016/j.neurobiolaging.2010.01.001  1
2010 Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10431-40. PMID 20685985 DOI: 10.1523/JNEUROSCI.1445-10.2010  1
2010 Wolfe MS, Selkoe DJ. Giving Alzheimer's the old one-two. Cell. 142: 194-6. PMID 20655461 DOI: 10.1016/j.cell.2010.07.006  1
2010 Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, ... ... Selkoe DJ, et al. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One. 5: e10504. PMID 20498699 DOI: 10.1371/journal.pone.0010504  1
2010 Li S, Shankar GM, Selkoe DJ. How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Frontiers in Cellular Neuroscience. 4: 5. PMID 20428510 DOI: 10.3389/fncel.2010.00005  1
2010 Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D, De Strooper B. Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. Journal of Alzheimer's Disease : Jad. 20: 1119-32. PMID 20413872 DOI: 10.3233/JAD-2010-091633  1
2010 Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain : a Journal of Neurology. 133: 1328-41. PMID 20403962 DOI: 10.1093/brain/awq065  1
2010 Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x  1
2010 Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. The Journal of Biological Chemistry. 285: 11378-91. PMID 20145246 DOI: 10.1074/jbc.M109.088815  1
2010 Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Medicine. 12: 27-43. PMID 20069392 DOI: 10.1007/s12017-009-8109-7  1
2009 Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Identification of beta-secretase (BACE1) substrates using quantitative proteomics. Plos One. 4: e8477. PMID 20041192 DOI: 10.1371/journal.pone.0008477  1
2009 Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Archives of Neurology. 66: 1247-53. PMID 19822780 DOI: 10.1001/archneurol.2009.207  1
2009 Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. Journal of Immunology (Baltimore, Md. : 1950). 183: 3522-30. PMID 19675171 DOI: 10.4049/jimmunol.0900620  1
2009 Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiology of Disease. 36: 293-302. PMID 19660551 DOI: 10.1016/j.nbd.2009.07.021  1
2009 Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63: 178-88. PMID 19640477 DOI: 10.1016/j.neuron.2009.07.003  1
2009 Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype. Journal of Neurochemistry. 111: 15-25. PMID 19627450 DOI: 10.1111/j.1471-4159.2009.06290.x  1
2009 Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 62: 788-801. PMID 19555648 DOI: 10.1016/j.neuron.2009.05.012  1
2009 Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/j.brainres.2009.01.008  1
2009 Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. Plos One. 4: e5274. PMID 19384407 DOI: 10.1371/journal.pone.0005274  1
2009 Li H, Wolfe MS, Selkoe DJ. Toward structural elucidation of the gamma-secretase complex. Structure (London, England : 1993). 17: 326-34. PMID 19278647 DOI: 10.1016/j.str.2009.01.007  1
2009 Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. Journal of Alzheimer's Disease : Jad. 16: 277-85. PMID 19221417 DOI: 10.3233/JAD-2009-0948  1
2009 Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Archives of Neurology. 66: 190-9. PMID 19204155 DOI: 10.1001/archneurol.2008.565  1
2009 Weihofen A, Thomas KJ, Ostaszewski BL, Cookson MR, Selkoe DJ. Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry. 48: 2045-52. PMID 19152501 DOI: 10.1021/bi8019178  1
2009 Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry. 48: 1077-83. PMID 19146388 DOI: 10.1021/bi801871h  1
2009 Osenkowski P, Li H, Ye W, Li D, Aeschbach L, Fraering PC, Wolfe MS, Selkoe DJ, Li H. Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. Journal of Molecular Biology. 385: 642-52. PMID 19013469 DOI: 10.1016/j.jmb.2008.10.078  1
2009 Ben Gedalya T, Loeb V, Israeli E, Altschuler Y, Selkoe DJ, Sharon R. Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic (Copenhagen, Denmark). 10: 218-34. PMID 18980610 DOI: 10.1111/j.1600-0854.2008.00853.x  1
2009 Okereke OI, Selkoe DJ, Pollak MN, Stampfer MJ, Hu FB, Hankinson SE, Grodstein F. A profile of impaired insulin degradation in relation to late-life cognitive decline: a preliminary investigation. International Journal of Geriatric Psychiatry. 24: 177-82. PMID 18612998 DOI: 10.1002/gps.2089  1
2008 Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. Plos Biology. 6: e257. PMID 18942891 DOI: 10.1371/journal.pbio.0060257  1
2008 Selkoe DJ. Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease. Handbook of Clinical Neurology. 89: 245-60. PMID 18631749 DOI: 10.1016/S0072-9752(07)01223-7  1
2008 Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 9582-7. PMID 18621727 DOI: 10.1073/pnas.0801261105  1
2008 Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiology of Disease. 31: 442-50. PMID 18602473 DOI: 10.1016/j.nbd.2008.06.001  1
2008 Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Development. 3: 15. PMID 18573216 DOI: 10.1186/1749-8104-3-15  1
2008 Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Medicine. 14: 837-42. PMID 18568035 DOI: 10.1038/nm1782  1
2008 Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ. Direct and potent regulation of gamma-secretase by its lipid microenvironment. The Journal of Biological Chemistry. 283: 22529-40. PMID 18539594 DOI: 10.1074/jbc.M801925200  0.88
2008 Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4231-7. PMID 18417702 DOI: 10.1523/JNEUROSCI.5161-07.2008  1
2008 Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behavioural Brain Research. 192: 106-13. PMID 18359102 DOI: 10.1016/j.bbr.2008.02.016  1
2008 Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiology of Disease. 30: 94-102. PMID 18289866 DOI: 10.1016/j.nbd.2007.12.005  1
2008 Okereke OI, Pollak MN, Hu FB, Hankinson SE, Selkoe DJ, Grodstein F. Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes. Psychoneuroendocrinology. 33: 455-61. PMID 18261857 DOI: 10.1016/j.psyneuen.2008.01.002  1
2008 Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Human Molecular Genetics. 17: 602-16. PMID 18003639 DOI: 10.1093/hmg/ddm334  1
2008 Cacquevel M, Aeschbach L, Osenkowski P, Li D, Ye W, Wolfe MS, Li H, Selkoe DJ, Fraering PC. Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. Journal of Neurochemistry. 104: 210-20. PMID 17986218 DOI: 10.1111/j.1471-4159.2007.05041.x  1
2007 Selkoe DJ. Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease. Nutrition Reviews. 65: S239-43. PMID 18240556 DOI: 10.1111/j.1753-4887.2007.tb00370.x  1
2007 Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14459-69. PMID 18160654 DOI: 10.1523/JNEUROSCI.4701-07.2007  1
2007 Assayag K, Yakunin E, Loeb V, Selkoe DJ, Sharon R. Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells. The American Journal of Pathology. 171: 2000-11. PMID 18055555 DOI: 10.2353/ajpath.2007.070373  1
2007 Selkoe DJ, Wolfe MS. Presenilin: running with scissors in the membrane. Cell. 131: 215-21. PMID 17956719 DOI: 10.1016/j.cell.2007.10.012  1
2007 Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. The Journal of Biological Chemistry. 282: 33305-12. PMID 17855343 DOI: 10.1074/jbc.M610390200  1
2007 Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. Plos Medicine. 4: e262. PMID 17760499 DOI: 10.1371/journal.pmed.0040262  1
2007 Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/ajpath.2007.070105  1
2007 Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochemical Society Transactions. 35: 416-20. PMID 17371289 DOI: 10.1042/BST0350416  1
2007 Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2866-75. PMID 17360908 DOI: 10.1523/JNEUROSCI.4970-06.2007  1
2007 Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiology of Disease. 26: 273-81. PMID 17321748 DOI: 10.1016/j.nbd.2007.01.004  1
2007 Chen AC, Selkoe DJ. Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554. Neuron. 53: 479-83. PMID 17296549 DOI: 10.1016/j.neuron.2007.01.023  1
2007 Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. Journal of Neurochemistry. 101: 1172-84. PMID 17286590 DOI: 10.1111/j.1471-4159.2006.04426.x  1
2007 Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews. Molecular Cell Biology. 8: 101-12. PMID 17245412 DOI: 10.1038/nrm2101  1
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/jbc.M609168200  1
2007 Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. International Journal of Geriatric Psychiatry. 22: 536-42. PMID 17096467 DOI: 10.1002/gps.1710  1
2006 Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of Neurology. 60: 668-76. PMID 17192927 DOI: 10.1002/ana.21051  1
2006 Leissring MA, Selkoe DJ. Structural biology: enzyme target to latch on to. Nature. 443: 761-2. PMID 17051198 DOI: 10.1038/nature05210  1
2006 Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10222-31. PMID 17021177 DOI: 10.1523/JNEUROSCI.2250-06.2006  1
2006 Selkoe DJ. Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise. Journal of Alzheimer's Disease : Jad. 9: 163-8. PMID 16914855  1
2006 Selkoe DJ. The ups and downs of Abeta. Nature Medicine. 12: 758-9; discussion 75. PMID 16829932 DOI: 10.1038/nm0706-758  1
2006 Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ, Li H. Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proceedings of the National Academy of Sciences of the United States of America. 103: 6889-94. PMID 16636269 DOI: 10.1073/pnas.0602321103  1
2006 Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic (Copenhagen, Denmark). 7: 354-64. PMID 16497228 DOI: 10.1111/j.1600-0854.2006.00388.x  1
2006 Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. The Journal of Physiology. 572: 477-92. PMID 16469784 DOI: 10.1113/jphysiol.2005.103754  1
2006 Selkoe DJ. The aging mind: Deciphering Alzheimer's disease & its antecedents Daedalus. 135: 58-67. DOI: 10.1162/001152606775321112  1
2006 Selkoe DJ. Amyloid β-peptide is produced by cultured cells during normal metabolism: A reprise Alzheimer's Disease: a Century of Scientific and Clinical Research. 163-168.  1
2005 Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochemical Society Transactions. 33: 1087-90. PMID 16246051 DOI: 10.1042/BST20051087  1
2005 Whalen BM, Selkoe DJ, Hartley DM. Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration. Neurobiology of Disease. 20: 254-66. PMID 16242634 DOI: 10.1016/j.nbd.2005.03.007  1
2005 Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS. gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. The Journal of Biological Chemistry. 280: 41987-96. PMID 16236717 DOI: 10.1074/jbc.M501368200  1
2005 LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ. Dopamine covalently modifies and functionally inactivates parkin. Nature Medicine. 11: 1214-21. PMID 16227987 DOI: 10.1038/nm1314  1
2005 Hemming ML, Selkoe DJ. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. The Journal of Biological Chemistry. 280: 37644-50. PMID 16154999 DOI: 10.1074/jbc.M508460200  1
2005 Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/JNEUROSCI.4883-04.2005  1
2005 Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 44: 6513-25. PMID 15850385 DOI: 10.1021/bi0476578  1
2005 Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nature Medicine. 11: 556-61. PMID 15834427 DOI: 10.1038/nm1234  1
2005 Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2455-62. PMID 15758153 DOI: 10.1523/JNEUROSCI.4391-04.2005  1
2005 Selkoe DJ. Defining molecular targets to prevent Alzheimer disease. Archives of Neurology. 62: 192-5. PMID 15710846 DOI: 10.1001/archneur.62.2.192  1
2005 Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nature Neuroscience. 8: 79-84. PMID 15608634 DOI: 10.1038/nn1372  1
2005 Chyung JH, Raper DM, Selkoe DJ. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. The Journal of Biological Chemistry. 280: 4383-92. PMID 15569674 DOI: 10.1074/jbc.M409272200  1
2004 Selkoe DJ. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nature Cell Biology. 6: 1054-61. PMID 15516999 DOI: 10.1038/ncb1104-1054  1
2004 Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 44: 181-93. PMID 15450169 DOI: 10.1016/j.neuron.2004.09.010  0.88
2004 Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neuroscience Letters. 366: 320-5. PMID 15288443 DOI: 10.1016/j.neulet.2004.05.060  1
2004 Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/BJ20041081  1
2004 Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Purification and characterization of the human gamma-secretase complex. Biochemistry. 43: 9774-89. PMID 15274632 DOI: 10.1021/bi0494976  1
2004 Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. The American Journal of Pathology. 165: 283-97. PMID 15215183  1
2004 Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein and Peptide Letters. 11: 213-28. PMID 15182223 DOI: 10.2174/0929866043407174  1
2004 Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K. A seed for Alzheimer amyloid in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4894-902. PMID 15152051 DOI: 10.1523/JNEUROSCI.0861-04.2004  1
2004 Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. The European Journal of Neuroscience. 19: 2839-46. PMID 15147317 DOI: 10.1111/j.1460-9568.2004.03389.x  1
2004 Selkoe DJ. Alzheimer disease: mechanistic understanding predicts novel therapies. Annals of Internal Medicine. 140: 627-38. PMID 15096334  1
2004 Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3370-8. PMID 15056716 DOI: 10.1523/JNEUROSCI.1633-03.2004  1
2004 Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. The American Journal of Pathology. 164: 1425-34. PMID 15039230  1
2004 Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry. 43: 323-33. PMID 14717586 DOI: 10.1021/bi035748j  1
2003 Selkoe DJ. Toward a remembrance of things past: deciphering Alzheimer disease. Harvey Lectures. 99: 23-45. PMID 15984550  1
2003 Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 40: 1087-93. PMID 14687544 DOI: 10.1016/S0896-6273(03)00787-6  1
2003 Selkoe DJ. Folding proteins in fatal ways. Nature. 426: 900-4. PMID 14685251 DOI: 10.1038/nature02264  1
2003 Selkoe DJ. Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman. Neurochemical Research. 28: 1705-13. PMID 14584824 DOI: 10.1023/A:1026065122854  1
2003 Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiology of Disease. 14: 194-204. PMID 14572442 DOI: 10.1016/S0969-9961(03)00123-2  1
2003 Chyung JH, Selkoe DJ. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. The Journal of Biological Chemistry. 278: 51035-43. PMID 14525989 DOI: 10.1074/jbc.M304989200  1
2003 Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. The Journal of Biological Chemistry. 278: 49874-81. PMID 14507911 DOI: 10.1074/jbc.M309127200  1
2003 Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiology of Disease. 14: 10-8. PMID 13678662 DOI: 10.1016/S0969-9961(03)00044-5  1
2003 Ye CP, Selkoe DJ, Hartley DM. Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures. Neurobiology of Disease. 13: 177-90. PMID 12901832 DOI: 10.1016/S0969-9961(03)00068-8  1
2003 Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of Clinical Investigation. 112: 415-22. PMID 12897209 DOI: 10.1172/JCI18104  1
2003 Leissring MA, Lu A, Condron MM, Teplow DB, Stein RL, Farris W, Selkoe DJ. Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. The Journal of Biological Chemistry. 278: 37314-20. PMID 12867419 DOI: 10.1074/jbc.M305627200  1
2003 LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. The Journal of Biological Chemistry. 278: 37213-22. PMID 12857757 DOI: 10.1074/jbc.M303941200  1
2003 Réchards M, Xia W, Oorschot VM, Selkoe DJ, Klumperman J. Presenilin-1 exists in both pre- and post-Golgi compartments and recycles via COPI-coated membranes. Traffic (Copenhagen, Denmark). 4: 553-65. PMID 12839498  1
2003 LaVoie MJ, Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. The Journal of Biological Chemistry. 278: 34427-37. PMID 12826675 DOI: 10.1074/jbc.M302659200  1
2003 Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/bi027375c  1
2003 Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 6382-7. PMID 12740439 DOI: 10.1073/pnas.1037392100  1
2003 Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 4162-7. PMID 12634421 DOI: 10.1073/pnas.0230450100  1
2003 Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 37: 583-95. PMID 12597857  0.88
2003 Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 42: 137-44. PMID 12515548 DOI: 10.1021/bi026888g  1
2003 Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annual Review of Pharmacology and Toxicology. 43: 545-84. PMID 12415125 DOI: 10.1146/annurev.pharmtox.43.100901.140248  1
2002 Weiner HL, Selkoe DJ. Inflammation and therapeutic vaccination in CNS diseases. Nature. 420: 879-84. PMID 12490962 DOI: 10.1038/nature01325  1
2002 Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 9: 88-102. PMID 12440481  1
2002 Selkoe DJ. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. The Journal of Clinical Investigation. 110: 1375-81. PMID 12438432 DOI: 10.1172/JCI16783  0.88
2002 Robinson SR, Bishop GM. The search for an amyloid solution. Science (New York, N.Y.). 298: 962-4; author reply . PMID 12416505 DOI: 10.1126/science.298.5595.962  1
2002 Selkoe DJ. Alzheimer's disease is a synaptic failure. Science (New York, N.Y.). 298: 789-91. PMID 12399581 DOI: 10.1126/science.1074069  1
2002 Craft DL, Wein LM, Selkoe DJ. A mathematical model of the impact of novel treatments on the A beta burden in the Alzheimer's brain, CSF and plasma. Bulletin of Mathematical Biology. 64: 1011-31. PMID 12391865 DOI: 10.1006/bulm.2002.0304  1
2002 Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochemical Society Transactions. 30: 552-7. PMID 12196135 DOI: 10.1042/  1
2002 Selkoe DJ, Podlisny MB. Deciphering the genetic basis of Alzheimer's disease. Annual Review of Genomics and Human Genetics. 3: 67-99. PMID 12142353 DOI: 10.1146/annurev.genom.3.022502.103022  1
2002 Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (New York, N.Y.). 297: 353-6. PMID 12130773 DOI: 10.1126/science.1072994  1
2002 Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. The Journal of Biological Chemistry. 277: 35113-7. PMID 12130643 DOI: 10.1074/jbc.M204446200  1
2002 Wolfe MS, Selkoe DJ. Biochemistry. Intramembrane proteases--mixing oil and water. Science (New York, N.Y.). 296: 2156-7. PMID 12077393 DOI: 10.1126/science.1073844  1
2002 Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. The American Journal of Pathology. 160: 1655-67. PMID 12000718 DOI: 10.1016/S0002-9440(10)61113-3  1
2002 Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nature Cell Biology. 4: E110-1; author reply. PMID 11988746 DOI: 10.1038/ncb0502-e110b  0.72
2002 Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416: 535-9. PMID 11932745 DOI: 10.1038/416535a  1
2002 Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proceedings of the National Academy of Sciences of the United States of America. 99: 2720-5. PMID 11867728 DOI: 10.1073/pnas.052436599  0.88
2002 Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ. Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. The Journal of Biological Chemistry. 277: 15069-75. PMID 11839734 DOI: 10.1074/jbc.M105375200  0.88
2002 Wang H, Wolosker H, Morris JF, Pevsner J, Snyder SH, Selkoe DJ. Naturally occurring free D-aspartate is a nuclear component of cells in the mammalian hypothalamo-neurohypophyseal system. Neuroscience. 109: 1-4. PMID 11784695 DOI: 10.1016/S0306-4522(01)00545-0  0.88
2002 Selkoe DJ. Introducing transglutaminase into the study of Alzheimer's disease. A personal look back. Neurochemistry International. 40: 13-6. PMID 11738468 DOI: 10.1016/S0197-0186(01)00057-2  0.88
2002 Kaufer D, Selkoe DJ. On the cutting edge of Alzheimer's disease therapy Patient Care. 36: 10-21.  1
2001 Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. Dna and Cell Biology. 20: 705-11. PMID 11788048 DOI: 10.1089/10445490152717569  1
2001 Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron. 32: 177-80. PMID 11683988 DOI: 10.1016/S0896-6273(01)00475-5  0.88
2001 Selkoe DJ. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 11039-41. PMID 11572965 DOI: 10.1073/pnas.211352598  1
2001 Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. The Journal of Biological Chemistry. 276: 40288-92. PMID 11544248 DOI: 10.1074/jbc.C100447200  1
2001 Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 10273-8. PMID 11517335 DOI: 10.1073/pnas.191118298  0.88
2001 Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 9110-5. PMID 11481478 DOI: 10.1073/pnas.171300598  0.88
2001 Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (New York, N.Y.). 293: 263-9. PMID 11431533 DOI: 10.1126/science.1060627  1
2001 Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. The Biochemical Journal. 355: 869-77. PMID 11311152  1
2001 Selkoe DJ. Presenilins, β-amyloid precursor protein and the molecular basis of Alzheimer's disease Clinical Neuroscience Research. 1: 91-103.  0.88
2000 Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Annals of the New York Academy of Sciences. 920: 328-31. PMID 11193172  0.4
2000 Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 223-6. PMID 11193154  0.88
2000 Moore CL, Diehl TS, Selkoe DJ, Wolfe MS. Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors. Annals of the New York Academy of Sciences. 920: 197-205. PMID 11193150  0.88
2000 Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (New York, N.Y.). 290: 2302-3. PMID 11125142 DOI: 10.1126/science.290.5500.2302  1
2000 Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiology of Disease. 7: 673-81. PMID 11114265 DOI: 10.1006/nbdi.2000.0322  1
2000 Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nature Structural Biology. 7: 1095-9. PMID 11101888 DOI: 10.1038/81937  1
2000 Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Annals of Neurology. 48: 567-79. PMID 11026440  0.4
2000 Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 166-78. PMID 11019857  1
2000 Moore CL, Leatherwood DD, Diehl TS, Selkoe DJ, Wolfe MS. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design. Journal of Medicinal Chemistry. 43: 3434-42. PMID 10978191 DOI: 10.1021/jm000100f  1
2000 Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 39: 10831-9. PMID 10978169 DOI: 10.1021/bi001048s  0.88
2000 Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9299-304. PMID 10922078 DOI: 10.1073/pnas.97.16.9299  1
2000 Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. Journal of Neurochemistry. 75: 583-93. PMID 10899933 DOI: 10.1046/j.1471-4159.2000.0750583.x  0.88
2000 Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nature Cell Biology. 2: 428-34. PMID 10878808 DOI: 10.1038/35017062  1
2000 Selkoe DJ, Wolfe MS. In search of gamma-secretase: presenilin at the cutting edge. Proceedings of the National Academy of Sciences of the United States of America. 97: 5690-2. PMID 10823929  0.48
2000 Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1657-65. PMID 10684867  0.32
2000 Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. The American Journal of Pathology. 156: 489-99. PMID 10666378 DOI: 10.1016/S0002-9440(10)64753-0  1
2000 Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. The Journal of Biological Chemistry. 275: 3173-8. PMID 10652302 DOI: 10.1074/jbc.275.5.3173  0.88
1999 Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. The Journal of Biological Chemistry. 274: 36801-7. PMID 10593990 DOI: 10.1074/jbc.274.51.36801  0.88
1999 Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8876-84. PMID 10516307  1
1999 Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry. 38: 11223-30. PMID 10471271 DOI: 10.1021/bi991080q  0.48
1999 Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. The Journal of Biological Chemistry. 274: 25945-52. PMID 10464339 DOI: 10.1074/jbc.274.36.25945  1
1999 Lemere CA, Grenfell TJ, Selkoe DJ. The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome. The American Journal of Pathology. 155: 29-37. PMID 10393833  0.4
1999 Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. The Journal of Biological Chemistry. 274: 18851-6. PMID 10383380 DOI: 10.1074/jbc.274.27.18851  1
1999 Watson DJ, Selkoe DJ, Teplow DB. Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein. The Biochemical Journal. 340: 703-9. PMID 10359654 DOI: 10.1042/0264-6021:3400703  1
1999 Querfurth HW, Jiang J, Xia W, Selkoe DJ. Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter. Gene. 232: 125-41. PMID 10333529  0.48
1999 Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398: 513-7. PMID 10206644 DOI: 10.1038/19077  0.88
1999 Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 38: 4720-7. PMID 10200159 DOI: 10.1021/bi982562p  0.88
1998 Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 37: 16465-71. PMID 9843412 DOI: 10.1021/bi9816195  0.88
1998 Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry. 273: 32730-8. PMID 9830016  0.88
1998 Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. The Journal of Biological Chemistry. 273: 32322-31. PMID 9822712  1
1998 Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiology of Disease. 5: 107-16. PMID 9746908 DOI: 10.1006/nbdi.1998.0183  1
1998 Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. The Journal of Biological Chemistry. 273: 12436-42. PMID 9575200  0.8
1998 Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry. 37: 3602-11. PMID 9521679 DOI: 10.1021/bi972029u  0.88
1998 Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432  1
1998 Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 391: 339-40. PMID 9450743 DOI: 10.1038/34800  1
1998 Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. Journal of Medicinal Chemistry. 41: 6-9. PMID 9438016 DOI: 10.1021/jm970621b  0.72
1997 Watson DJ, Lander AD, Selkoe DJ. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red. The Journal of Biological Chemistry. 272: 31617-24. PMID 9395501 DOI: 10.1074/jbc.272.50.31617  1
1997 Querfurth HW, Jiang J, Geiger JD, Selkoe DJ. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. Journal of Neurochemistry. 69: 1580-91. PMID 9326287  0.88
1997 Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 8208-13. PMID 9223340  0.8
1997 Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/nbdi.1997.0129  1
1997 Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89: 629-39. PMID 9160754  1
1997 Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 94: 5349-54. PMID 9144240  1
1997 Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/jbc.272.12.7977  0.88
1997 Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ. Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. The Journal of Biological Chemistry. 272: 6641-6. PMID 9045694 DOI: 10.1074/jbc.272.10.6641  0.88
1997 Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878  1
1997 Yamazaki T, Koo EH, Selkoe DJ. Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1004-10. PMID 8994055  0.8
1997 Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, ... ... Selkoe DJ, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nature Medicine. 3: 67-72. PMID 8986743 DOI: 10.1038/nm0197-67  1
1996 Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiology of Disease. 3: 51-63. PMID 9173912 DOI: 10.1006/nbdi.1996.0005  0.4
1996 Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiology of Disease. 3: 16-32. PMID 9173910 DOI: 10.1006/nbdi.1996.0003  1
1996 Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483  1
1996 Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. The Journal of Biological Chemistry. 271: 33623-31. PMID 8969231 DOI: 10.1074/jbc.271.52.33623  1
1996 Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ. Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. The Journal of Biological Chemistry. 271: 32916-22. PMID 8955133 DOI: 10.1074/jbc.271.51.32916  0.88
1996 Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9  1
1996 Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proceedings of the National Academy of Sciences of the United States of America. 93: 13170-5. PMID 8917563 DOI: 10.1073/pnas.93.23.13170  1
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, ... Selkoe DJ, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/nm1096-1146  0.88
1996 Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiology of Aging. 17: 653-9. PMID 8832640  0.88
1996 Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American Journal of Pathology. 149: 1063-71. PMID 8780408  1
1996 Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 17: 171-9. PMID 8755488 DOI: 10.1016/S0896-6273(00)80290-1  1
1996 Yamazaki T, Koo EH, Selkoe DJ. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. Journal of Cell Science. 109: 999-1008. PMID 8743947  0.8
1996 Koo EH, Squazzo SL, Selkoe DJ, Koo CH. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. Journal of Cell Science. 109: 991-8. PMID 8743946  0.8
1996 Tamaoka A, Endoh R, Shoji S, Takahashi H, Hirokawa K, Teplow DB, Selkoe DJ, Mori H. Antibodies to amyloid beta protein (A beta) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Neurobiology of Aging. 17: 405-14. PMID 8725902 DOI: 10.1016/0197-4580(96)00031-0  1
1996 Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. The Journal of Biological Chemistry. 271: 8443-51. PMID 8626544 DOI: 10.1074/jbc.271.14.8443  1
1996 Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127  0.88
1995 Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiology of Disease. 2: 177-87. PMID 9174001 DOI: 10.1006/nbdi.1995.0019  0.88
1995 Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neuroscience Letters. 198: 52-6. PMID 8570096 DOI: 10.1016/0304-3940(95)11944-R  1
1995 Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2157-67. PMID 7891158  1
1995 Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 6186-92. PMID 7890753 DOI: 10.1074/jbc.270.11.6186  0.88
1995 Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/jcb.128.4.537  1
1995 Haas C, Hung AY, Citron M, Teplow DB, Selkoe DJ. beta-Amyloid, protein processing and Alzheimer's disease. Arzneimittel-Forschung. 45: 398-402. PMID 7763333  1
1995 Yamazaki T, Selkoe DJ, Koo EH. Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. The Journal of Cell Biology. 129: 431-42. PMID 7721945  0.8
1995 Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. The Journal of Biological Chemistry. 270: 9564-70. PMID 7721886  1
1995 Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American Journal of Pathology. 146: 848-60. PMID 7717452  1
1995 Citron M, Teplow DB, Selkoe DJ. Generation of amyloid beta protein from its precursor is sequence specific. Neuron. 14: 661-70. PMID 7695913 DOI: 10.1016/0896-6273(95)90323-2  1
1995 Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical Journal. 311: 299-305. PMID 7575468  1
1995 Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Medicine. 1: 1291-6. PMID 7489411  1
1994 Hung AY, Selkoe DJ. Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. The Embo Journal. 13: 534-42. PMID 8313898  0.8
1994 Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445  1
1994 Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 7104-8. PMID 8041753  0.8
1994 Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 17741-8. PMID 8021287  1
1994 Citron M, Vigo-Pelfrey C, Teplow DB, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe DJ. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proceedings of the National Academy of Sciences of the United States of America. 91: 11993-7. PMID 7991571 DOI: 10.1073/pnas.91.25.11993  0.88
1994 Maness LM, Banks WA, Podlisny MB, Selkoe DJ, Kastin AJ. Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier. Life Sciences. 55: 1643-50. PMID 7968239  0.52
1993 Koo EH, Park L, Selkoe DJ. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 90: 4748-52. PMID 8506329  0.8
1993 Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. The Journal of Biological Chemistry. 268: 3021-4. PMID 8428976  1
1993 Podlisny MB, Stephenson DT, Frosch MP, Tolan DR, Lieberburg I, Clemens JA, Selkoe DJ. Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity. The American Journal of Pathology. 142: 17-24. PMID 8424453  1
1993 Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiology of Aging. 14: 571-3. PMID 8295660  1
1993 Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 75: 1039-42. PMID 8261505  1
1993 Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Annals of the New York Academy of Sciences. 695: 109-16. PMID 8239267 DOI: 10.1111/j.1749-6632.1993.tb23037.x  1
1993 Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807  1
1992 Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. The American Journal of Pathology. 141: 249-59. PMID 1632466  0.6
1992 Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiology of Aging. 13: 421-34. PMID 1625772 DOI: 10.1016/0197-4580(92)90117-G  1
1992 Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500a0  1
1992 Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360: 672-4. PMID 1465129 DOI: 10.1038/360672a0  0.88
1992 Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry. 31: 10716-23. PMID 1420187  1
1992 Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654  1
1992 Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ. Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex. Neurobiology of Aging. 13: 561-7. PMID 1281288 DOI: 10.1016/0197-4580(92)90056-4  1
1991 Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3783-93. PMID 1744690  1
1989 Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 32: 715-20. PMID 2689908 DOI: 10.1016/0306-4522(89)90292-3  1
1988 Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 52: 487-501. PMID 3257719 DOI: 10.1016/0092-8674(88)90462-X  1
1988 Nukina N, Kosik KS, Selkoe DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neuroscience Letters. 87: 240-6. PMID 3132653 DOI: 10.1016/0304-3940(88)90455-7  1
1987 Nukina N, Kosik KS, Selkoe DJ. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proceedings of the National Academy of Sciences of the United States of America. 84: 3415-9. PMID 3106969  1
1986 Selkoe DJ, Abraham CR. Isolation of paired helical filaments and amyloid fibers from human brain. Methods in Enzymology. 134: 388-404. PMID 3821571 DOI: 10.1016/0076-6879(86)34105-3  1
1986 Selkoe DJ, Abraham CR, Podlisny MB, Duffy LK. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. Journal of Neurochemistry. 46: 1820-34. PMID 3517233 DOI: 10.1111/j.1471-4159.1986.tb08501.x  1
1983 Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 304: 727-30. PMID 6350889  0.56
1982 Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proceedings of the National Academy of Sciences of the United States of America. 79: 6070-4. PMID 6136967  0.56
1982 Selkoe DJ, Ihara Y, Salazar FJ. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (New York, N.Y.). 215: 1243-5. PMID 6120571  0.56
1979 Liem RK, Selkoe DJ, Yen SH, Salomon G, Shelanski ML. New insights on the composition of neurofilaments. Research Publications - Association For Research in Nervous and Mental Disease. 57: 145-52. PMID 419331  0.48
1979 Selkoe DJ, Liem RK, Yen SH, Shelanski ML. Biochemical and immunological characterization of neurofilaments in experimental neurofibrillary degeneration induced by aluminum. Brain Research. 163: 235-52. PMID 371751 DOI: 10.1016/0006-8993(79)90352-4  0.88
1978 Selkoe DJ, Luckenbill-Edds L, Shelanski ML. Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: methyl n-butyl ketone, n-hexane and derivatives. Journal of Neuropathology and Experimental Neurology. 37: 768-89. PMID 739276  0.48
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