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Dennis J. Selkoe, MD - Publications

Affiliations: 
Neurology Harvard Medical School, Boston, MA, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=1
Website:
http://selkoelab.bwh.harvard.edu/index.htm

355 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Liu L, Cai Y, Lauro BM, Meunier AL, Chhatwal J, Selkoe DJ. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration. Biochemical and Biophysical Research Communications. 611: 85-90. PMID 35483223 DOI: 10.1016/j.bbrc.2022.04.077  0.315
2022 Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35278341 DOI: 10.1002/alz.12646  0.36
2022 Stern AM, Liu L, Jin S, Liu W, Meunier AL, Ericsson M, Miller MB, Batson M, Sun T, Kathuria S, Reczek D, Pradier L, Selkoe DJ. A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain. Brain : a Journal of Neurology. PMID 35084489 DOI: 10.1093/brain/awac023  0.392
2021 Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34550630 DOI: 10.1002/alz.12457  0.397
2021 Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, ... ... Selkoe DJ, et al. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. PMID 34473944 DOI: 10.1016/j.neuron.2021.08.003  0.706
2021 Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. The Journal of Biological Chemistry. 100393. PMID 33571524 DOI: 10.1016/j.jbc.2021.100393  0.403
2020 Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nature Communications. 11: 6024. PMID 33247134 DOI: 10.1038/s41467-020-19543-w  0.54
2020 Lauwers E, Lalli G, Brandner S, Collinge J, Compernolle V, Duyckaerts C, Edgren G, Haïk S, Hardy J, Helmy A, Ivinson AJ, Jaunmuktane Z, Jucker M, Knight R, Lemmens R, ... ... Selkoe DJ, et al. Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet. Neurology. 19: 872-878. PMID 32949547 DOI: 10.1016/S1474-4422(20)30238-6  0.401
2020 Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J, Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. The Journal of Prevention of Alzheimer's Disease. 7: 146-151. PMID 32463066 DOI: 10.14283/jpad.2020.24  0.453
2020 Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, ... Selkoe DJ, et al. Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies. Brain Communications. 2: fcaa010. PMID 32280944 DOI: 10.1093/braincomms/fcaa010  0.671
2020 Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003  0.616
2020 Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase. Alzheimer's Research & Therapy. 12: 27. PMID 32192521 DOI: 10.1186/S13195-020-00593-7  0.599
2019 Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Frontiers in Neuroscience. 13: 1208. PMID 31849573 DOI: 10.3389/Fnins.2019.01208  0.567
2019 Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548371 DOI: 10.1073/Pnas.1903216116  0.686
2019 Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiology of Aging. PMID 31500908 DOI: 10.1016/J.Neurobiolaging.2019.07.002  0.454
2019 Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31416794 DOI: 10.1016/J.Jalz.2019.06.3918  0.513
2019 Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF. Annals of Neurology. PMID 31168802 DOI: 10.1002/ana.25513  0.635
2019 Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain. Brain : a Journal of Neurology. 142: 1441-1457. PMID 31032851 DOI: 10.1093/Brain/Awz066  0.697
2019 Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. The Journal of Cell Biology. PMID 30626721 DOI: 10.1083/Jcb.201806205  0.508
2019 Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. P1-218: A NOVEL CELLULAR COMPLEX OF BACE1 AND γ-SECRETASE SEQUENTIALLY GENERATES Aβ FROM APP Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.773  0.438
2018 Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Selkoe D, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/J.Molcel.2018.11.028  0.319
2018 Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30419228 DOI: 10.1016/J.Jalz.2018.09.010  0.808
2018 Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathologica Communications. 6: 121. PMID 30409172 DOI: 10.1186/S40478-018-0626-X  0.54
2018 Zhao J, Li A, Rajsombath M, Dang Y, Selkoe DJ, Li S. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. Iscience. 6: 138-150. PMID 30240608 DOI: 10.1016/j.isci.2018.07.018  0.332
2018 Xu H, Rajsombath MM, Weikop P, Selkoe DJ. Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. Embo Molecular Medicine. PMID 30093491 DOI: 10.15252/emmm.201808931  0.713
2018 Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease. Nature Communications. 9: 2676. PMID 29992960 DOI: 10.1038/S41467-018-05068-W  0.813
2018 El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathologica. PMID 29982852 DOI: 10.1007/S00401-018-1880-5  0.784
2018 Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International Journal of Molecular Sciences. 19. PMID 29495441 DOI: 10.3390/Ijms19030663  0.812
2017 Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, ... ... Selkoe DJ, et al. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. PMID 29153990 DOI: 10.1016/J.Stemcr.2017.10.015  0.817
2017 Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Human Molecular Genetics. 26: 3466-3481. PMID 28911198 DOI: 10.1093/hmg/ddx227  0.322
2017 Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Developmental Biology. PMID 28284905 DOI: 10.1016/J.Ydbio.2017.03.007  0.728
2017 Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 152-163. PMID 28053038 DOI: 10.1523/JNEUROSCI.1698-16.2016  0.813
2016 Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D. Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9041-56. PMID 27581448 DOI: 10.1523/JNEUROSCI.1023-16.2016  0.748
2016 Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones. Bioorganic & Medicinal Chemistry Letters. PMID 27038496 DOI: 10.1016/j.bmcl.2016.03.077  0.308
2016 Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science (New York, N.Y.). PMID 27033548 DOI: 10.1126/Science.Aad8373  0.607
2016 Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. Embo Molecular Medicine. PMID 27025652 DOI: 10.15252/Emmm.201606210  0.441
2016 Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols. Bioorganic & Medicinal Chemistry Letters. PMID 27020305 DOI: 10.1016/j.bmcl.2016.03.042  0.313
2016 Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27013392 DOI: 10.1016/j.bmcl.2016.03.040  0.366
2016 Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Reviews. Neuroscience. 17: 251-60. PMID 26988744 DOI: 10.1038/nrn.2016.13  0.594
2015 Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. The Journal of Cell Biology. 211: 1157-76. PMID 26694839 DOI: 10.1083/Jcb.201502001  0.683
2015 Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J. A Fluorescent Analog of Batimastat Enables Imaging of α-Secretase in Living Cells. Acs Chemical Neuroscience. PMID 26559179 DOI: 10.1021/Acschemneuro.5B00283  0.572
2015 Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiology of Disease. 85: 111-121. PMID 26525100 DOI: 10.1016/J.Nbd.2015.10.019  0.787
2015 Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Reports. PMID 26299970 DOI: 10.1016/J.Celrep.2015.07.061  0.721
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, ... Selkoe DJ, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887  0.597
2015 Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10851-65. PMID 26224867 DOI: 10.1523/Jneurosci.0387-15.2015  0.773
2015 Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... Selkoe DJ, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a Journal of Neurology. 138: 2659-71. PMID 26220939 DOI: 10.1093/Brain/Awv202  0.695
2015 Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 9596-601. PMID 26153422 DOI: 10.1073/pnas.1505953112  0.361
2015 Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 7314. PMID 26076669 DOI: 10.1038/Ncomms8314  0.3
2015 Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/S13195-015-0100-Y  0.594
2014 Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. American Journal of Hematology. 89: 974-7. PMID 25043722 DOI: 10.1002/Ajh.23796  0.642
2014 Wolfe MS, Selkoe DJ. γ-Secretase: a horseshoe structure brings good luck. Cell. 158: 247-9. PMID 25036627 DOI: 10.1016/j.cell.2014.06.043  0.311
2014 Holmes O, Paturi S, Selkoe DJ, Wolfe MS. Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry. 53: 4393-406. PMID 24941111 DOI: 10.1021/bi500489j  0.373
2014 Holmes O, Paturi S, Wolfe MS, Selkoe DJ. Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies. Journal of Neurochemistry. 131: 94-100. PMID 24865334 DOI: 10.1111/Jnc.12772  0.39
2014 Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. The Lancet. Neurology. 13: 614-29. PMID 24849862 DOI: 10.1016/S1474-4422(14)70090-0  0.368
2014 Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 53: 3908-21. PMID 24840308 DOI: 10.1021/Bi5003053  0.64
2014 Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron. 82: 308-19. PMID 24685176 DOI: 10.1016/J.Neuron.2014.02.027  0.574
2014 Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics. 23: 3523-36. PMID 24524897 DOI: 10.1093/Hmg/Ddu064  0.824
2014 Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of α-synuclein Neurodegenerative Diseases. 13: 114-117. PMID 24192542 DOI: 10.1159/000355516  0.375
2013 Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous α-synuclein. Plos One. 8: e81314. PMID 24278419 DOI: 10.1371/journal.pone.0081314  0.329
2013 Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, ... ... Selkoe DJ, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635  0.351
2013 Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, ... ... Selkoe DJ, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 81: 1531-7. PMID 24068787 DOI: 10.1212/Wnl.0B013E3182A95818  0.662
2013 Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 52: 3264-77. PMID 23597280 DOI: 10.1021/Bi400165F  0.811
2013 Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia. 61: 985-1002. PMID 23536313 DOI: 10.1002/Glia.22490  0.747
2013 Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron. 77: 929-41. PMID 23473322 DOI: 10.1016/J.Neuron.2012.12.040  0.737
2013 Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 99-112. PMID 23375565 DOI: 10.1016/J.Jalz.2012.11.005  0.754
2013 Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells. The Journal of Biological Chemistry. 288: 6371-85. PMID 23319586 DOI: 10.1074/jbc.M112.403311  0.352
2013 Augelli-Szafran C, Brogan K, Cai C, Chen J, Gu Y, Selkoe D, Wei H, Wolfe M, Zhang J. Gamma-secretase as a target for Alzheimer's disease therapy: Small-molecule development Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1687  0.321
2013 Muratore C, Rice H, Srikanth P, Selkoe D, Young-Pearse T. O1-01-05: Human iPSC-derived neurons reveal novel effects of the APP London mutation and show cell fate-specific Alzheimer's disease relevant phenotypes Alzheimer's & Dementia. 9: P126-P127. DOI: 10.1016/J.Jalz.2013.04.053  0.801
2012 Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. Acs Chemical Neuroscience. 3: 941-51. PMID 23205187 DOI: 10.1021/Cn3000857  0.362
2012 Holtzman DM, Mandelkow E, Selkoe DJ. Alzheimer disease in 2020. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23125202 DOI: 10.1101/Cshperspect.A011585  0.336
2012 Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development (Cambridge, England). 139: 3986-96. PMID 22992957 DOI: 10.1242/Dev.082909  0.812
2012 Mucke L, Selkoe DJ. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harbor Perspectives in Medicine. 2: a006338. PMID 22762015 DOI: 10.1101/cshperspect.a006338  0.406
2012 Holmes O, Paturi S, Ye W, Wolfe MS, Selkoe DJ. Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry. 51: 3565-75. PMID 22489600 DOI: 10.1021/bi300303g  0.358
2012 Koyama A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F. Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Archives of Neurology. 69: 824-31. PMID 22451159 DOI: 10.1001/archneurol.2011.1841  0.332
2012 Selkoe D, Mandelkow E, Holtzman D. Deciphering Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a011460. PMID 22315723 DOI: 10.1101/Cshperspect.A011460  0.339
2012 Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, ... ... Selkoe DJ, et al. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. 39: 209-19. PMID 22218879 DOI: 10.1007/S00259-011-2045-0  0.491
2012 Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, Selkoe DJ, Sharon R. Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathology (Zurich, Switzerland). 22: 280-94. PMID 21929559 DOI: 10.1111/j.1750-3639.2011.00530.x  0.35
2011 Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Archives of Neurology. 68: 1385-92. PMID 22084122 DOI: 10.1001/Archneurol.2011.242  0.338
2011 Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, Schwarz TL. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 147: 893-906. PMID 22078885 DOI: 10.1016/J.Cell.2011.10.018  0.631
2011 Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15861-9. PMID 22049429 DOI: 10.1523/Jneurosci.3272-11.2011  0.621
2011 Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Archives of Neurology. 68: 1239-44. PMID 21987540 DOI: 10.1001/Archneurol.2011.203  0.335
2011 Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, ... ... Selkoe DJ, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2283-6. PMID 21953863 DOI: 10.1002/Mds.23934  0.69
2011 Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6627-38. PMID 21543591 DOI: 10.1523/Jneurosci.0203-11.2011  0.753
2011 Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. 108: 5819-24. PMID 21421841 DOI: 10.1073/Pnas.1017033108  0.652
2011 Davis RC, Marsden IT, Maloney MT, Minamide LS, Podlisny M, Selkoe DJ, Bamburg JR. Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Molecular Neurodegeneration. 6: 10. PMID 21261978 DOI: 10.1186/1750-1326-6-10  0.318
2011 Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain. Methods in Molecular Biology (Clifton, N.J.). 670: 33-44. PMID 20967581 DOI: 10.1007/978-1-60761-744-0_3  0.614
2011 Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of Aging. 32: 2211-8. PMID 20097446 DOI: 10.1016/J.Neurobiolaging.2010.01.001  0.569
2011 Rice H, Young-Pearse T, Selkoe D. P2-310: Candidate-based search for Amyloid Precursor Protein ligands that modulate α-secretase cleavage Alzheimer's & Dementia. 7: S409-S410. DOI: 10.1016/J.Jalz.2011.05.1188  0.795
2010 Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10431-40. PMID 20685985 DOI: 10.1523/Jneurosci.1445-10.2010  0.72
2010 Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D, De Strooper B. Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. Journal of Alzheimer's Disease : Jad. 20: 1119-32. PMID 20413872 DOI: 10.3233/JAD-2010-091633  0.399
2010 Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain : a Journal of Neurology. 133: 1328-41. PMID 20403962 DOI: 10.1093/Brain/Awq065  0.645
2010 Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x  0.649
2010 Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. The Journal of Biological Chemistry. 285: 11378-91. PMID 20145246 DOI: 10.1074/Jbc.M109.088815  0.781
2010 Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Medicine. 12: 27-43. PMID 20069392 DOI: 10.1007/S12017-009-8109-7  0.495
2010 Shahani N, Young-Pearse T, Selkoe D, Sawa A. P2-247: Role of Disrupted-in-Schizophrenia-1 (DISC1) in amyloid precursor protein (APP) processing and Aβ generation Alzheimer's & Dementia. 6: S386-S387. DOI: 10.1016/J.Jalz.2010.05.1296  0.707
2010 Bamburg JR, Bernstein BW, Davis RC, Goldsbury C, Maloney MT, Marsden IT, Minamide LS, Pak CW, Perry G, Podlisny MB, Selkoe DJ, Shaw AE, Siedlak SL, Whiteman IT. P2-219: ADF/cofilin-actin rods and synaptic loss in Alzheimer's disease Alzheimer's & Dementia. 6: S378-S378. DOI: 10.1016/J.Jalz.2010.05.1268  0.319
2009 Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Identification of beta-secretase (BACE1) substrates using quantitative proteomics. Plos One. 4: e8477. PMID 20041192 DOI: 10.1371/Journal.Pone.0008477  0.735
2009 Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Archives of Neurology. 66: 1247-53. PMID 19822780 DOI: 10.1001/archneurol.2009.207  0.355
2009 Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. Journal of Immunology (Baltimore, Md. : 1950). 183: 3522-30. PMID 19675171 DOI: 10.4049/Jimmunol.0900620  0.53
2009 Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiology of Disease. 36: 293-302. PMID 19660551 DOI: 10.1016/J.Nbd.2009.07.021  0.644
2009 Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63: 178-88. PMID 19640477 DOI: 10.1016/J.Neuron.2009.07.003  0.538
2009 Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype. Journal of Neurochemistry. 111: 15-25. PMID 19627450 DOI: 10.1111/J.1471-4159.2009.06290.X  0.777
2009 Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 62: 788-801. PMID 19555648 DOI: 10.1016/J.Neuron.2009.05.012  0.725
2009 Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/J.Brainres.2009.01.008  0.651
2009 Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. Plos One. 4: e5274. PMID 19384407 DOI: 10.1371/Journal.Pone.0005274  0.327
2009 Li H, Wolfe MS, Selkoe DJ. Toward structural elucidation of the gamma-secretase complex. Structure (London, England : 1993). 17: 326-34. PMID 19278647 DOI: 10.1016/J.Str.2009.01.007  0.35
2009 Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. Journal of Alzheimer's Disease : Jad. 16: 277-85. PMID 19221417 DOI: 10.3233/Jad-2009-0948  0.402
2009 Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Archives of Neurology. 66: 190-9. PMID 19204155 DOI: 10.1001/Archneurol.2008.565  0.627
2009 Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry. 48: 1077-83. PMID 19146388 DOI: 10.1021/Bi801871H  0.79
2009 Osenkowski P, Li H, Ye W, Li D, Aeschbach L, Fraering PC, Wolfe MS, Selkoe DJ, Li H. Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. Journal of Molecular Biology. 385: 642-52. PMID 19013469 DOI: 10.1016/J.Jmb.2008.10.078  0.402
2008 Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. Plos Biology. 6: e257. PMID 18942891 DOI: 10.1371/Journal.Pbio.0060257  0.735
2008 Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 9582-7. PMID 18621727 DOI: 10.1073/Pnas.0801261105  0.344
2008 Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiology of Disease. 31: 442-50. PMID 18602473 DOI: 10.1016/J.Nbd.2008.06.001  0.623
2008 Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Development. 3: 15. PMID 18573216 DOI: 10.1186/1749-8104-3-15  0.785
2008 Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Medicine. 14: 837-42. PMID 18568035 DOI: 10.1038/Nm1782  0.654
2008 Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ. Direct and potent regulation of gamma-secretase by its lipid microenvironment. The Journal of Biological Chemistry. 283: 22529-40. PMID 18539594 DOI: 10.1074/jbc.M801925200  0.324
2008 Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4231-7. PMID 18417702 DOI: 10.1523/Jneurosci.5161-07.2008  0.647
2008 Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiology of Disease. 30: 94-102. PMID 18289866 DOI: 10.1016/J.Nbd.2007.12.005  0.639
2008 Cacquevel M, Aeschbach L, Osenkowski P, Li D, Ye W, Wolfe MS, Li H, Selkoe DJ, Fraering PC. Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. Journal of Neurochemistry. 104: 210-20. PMID 17986218 DOI: 10.1111/J.1471-4159.2007.05041.X  0.411
2008 Shimura H, Schlossmacher M, Hattori N, Mizuno Y, Kosik K, Selkoe D. Interaction between parkin and alpha-synuclein Journal of Neurochemistry. 81: 3-3. DOI: 10.1046/J.1471-4159.81.S1.49_4.X  0.531
2008 Xia W, Yang T, Smith IM, Walsh DM, Selkoe DJ. P1-368: Monomeric and oligmeric Aβ assays on plasma of Alzheimer patients Alzheimer's & Dementia. 4: T327-T327. DOI: 10.1016/j.jalz.2008.05.950  0.575
2008 Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. O2-02-02: Soluble amyloid β-protein dimers isolated directly from Alzheimer's disease patients potently impair synaptic plasticity and memory Alzheimer's & Dementia. 4: T133-T133. DOI: 10.1016/J.Jalz.2008.05.314  0.361
2008 McDonald JM, Brayne C, Savva G, Mattews FE, Welzel A, Shankar GM, Ince PG, Selkoe DJ, Walsh DM. P3-415: The presence of Abeta dimers in soluble brain extract is associated with dementia Alzheimer's & Dementia. 4: T643-T643. DOI: 10.1016/J.Jalz.2008.05.1986  0.586
2007 Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14459-69. PMID 18160654 DOI: 10.1523/Jneurosci.4701-07.2007  0.74
2007 Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. Plos Medicine. 4: e262. PMID 17760499 DOI: 10.1371/Journal.Pmed.0040262  0.76
2007 Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/Ajpath.2007.070105  0.653
2007 Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochemical Society Transactions. 35: 416-20. PMID 17371289 DOI: 10.1042/Bst0350416  0.653
2007 Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2866-75. PMID 17360908 DOI: 10.1523/Jneurosci.4970-06.2007  0.64
2007 Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiology of Disease. 26: 273-81. PMID 17321748 DOI: 10.1016/J.Nbd.2007.01.004  0.752
2007 Chen AC, Selkoe DJ. Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554. Neuron. 53: 479-83. PMID 17296549 DOI: 10.1016/j.neuron.2007.01.023  0.518
2007 Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. Journal of Neurochemistry. 101: 1172-84. PMID 17286590 DOI: 10.1111/j.1471-4159.2006.04426.x  0.626
2007 Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews. Molecular Cell Biology. 8: 101-12. PMID 17245412 DOI: 10.1038/Nrm2101  0.466
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/Jbc.M609168200  0.365
2007 Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. International Journal of Geriatric Psychiatry. 22: 536-42. PMID 17096467 DOI: 10.1002/Gps.1710  0.321
2007 Sperling R, LaViolette P, White E, Becker JA, Moran E, Gregas M, Klunk W, Mathis C, Price J, Fischman A, Selkoe D, Rentz D, Johnson K. O1-05-01: Cortical amyloid deposition related to failure of hippocampal activation Alzheimers & Dementia. 3. DOI: 10.1016/J.Jalz.2007.04.068  0.477
2006 Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of Neurology. 60: 668-76. PMID 17192927 DOI: 10.1002/Ana.21051  0.626
2006 Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10222-31. PMID 17021177 DOI: 10.1523/Jneurosci.2250-06.2006  0.48
2006 Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ, Li H. Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proceedings of the National Academy of Sciences of the United States of America. 103: 6889-94. PMID 16636269 DOI: 10.1073/Pnas.0602321103  0.386
2006 Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic (Copenhagen, Denmark). 7: 354-64. PMID 16497228 DOI: 10.1111/j.1600-0854.2006.00388.x  0.427
2006 Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. The Journal of Physiology. 572: 477-92. PMID 16469784 DOI: 10.1113/Jphysiol.2005.103754  0.636
2006 Walsh DM, Jin M, Wang Z, Liu W, Lagomarsino V, Weeden T, Reczek D, Young-Pearse T, Pradier L, Selkoe DJ. P1-106: A HEAD-TO-HEAD COMPARISON OF LEAD CLINICAL ANTI-Aβ ANTIBODIES Alzheimer's & Dementia. 14: P312-P312. DOI: 10.1016/J.Jalz.2018.06.109  0.734
2006 Betts V, Leissring MA, Selkoe DJ, Walsh DM. P1-391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ Alzheimer's & Dementia. 2: S212-S213. DOI: 10.1016/J.Jalz.2006.05.769  0.581
2006 Young-Pearse TL, Bai J, Zheng J, LoTurco J, Selkoe DJ. O4-05-08: In utero gene transfer reveals a function for APP in cortical cell migration Alzheimer's & Dementia. 2: S86-S87. DOI: 10.1016/J.Jalz.2006.05.334  0.658
2006 Sperling R, Depeau K, Miller S, Chua E, Rentz D, Dickerson B, Atri A, Selkoe D, Johnson K, Calhoun V, Albert M, Celone K. Ic-101-05 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2344  0.376
2006 Johnson KA, Pollen D, Rentz D, Moran E, Becker JA, Moonis M, Swearer J, Hyman B, Selkoe D, Sperling R, DeKosky S, Matthis C, Klunk W, Fischman A. IC-103-03: Amyloid deposition in presymptomatic familial Alzheimer's disease Alzheimer's & Dementia. 2: S653-S653. DOI: 10.1016/J.Jalz.2006.05.2198  0.516
2006 Minogue AM, Fadeeva JV, Tang J, Wasco W, Selkoe DJ, Walsh DM. P3-352: APLP1-derived peptides do not undergo rapid fibrillogenesis Alzheimer's & Dementia. 2: S478-S478. DOI: 10.1016/J.Jalz.2006.05.1622  0.514
2006 Sperling R, Depeau K, Miller S, Chua E, Dorene R, Dickerson B, Atri A, Selkoe D, Albert M, Calhoun V, Celone K. P2-302: FMRI alterations medial temporal and neocortical networks in MCI and AD Alzheimer's & Dementia. 2: S328-S329. DOI: 10.1016/J.Jalz.2006.05.1142  0.453
2006 Johnson KA, Pollen D, Rentz D, Moran E, Becker JA, Moonis M, Swearer J, Hyman B, Selkoe D, Sperling R, DeKosky S, Matthis C, Klunk W, Fischman A. P2-268: Amyloid deposition in presymptomatic familial Alzheimer's disease Alzheimer's & Dementia. 2: S317-S317. DOI: 10.1016/J.Jalz.2006.05.1107  0.529
2006 Selkoe D, Townsend M, Shankar G, Mehta T, Podlisny M, Walsh D. S1-02-04: Role of AB oligomers in AD Alzheimer's & Dementia. 2: S4-S4. DOI: 10.1016/J.Jalz.2006.05.016  0.586
2005 Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochemical Society Transactions. 33: 1087-90. PMID 16246051 DOI: 10.1042/Bst20051087  0.652
2005 Whalen BM, Selkoe DJ, Hartley DM. Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration. Neurobiology of Disease. 20: 254-66. PMID 16242634 DOI: 10.1016/J.Nbd.2005.03.007  0.814
2005 Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS. gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. The Journal of Biological Chemistry. 280: 41987-96. PMID 16236717 DOI: 10.1074/Jbc.M501368200  0.7
2005 LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ. Dopamine covalently modifies and functionally inactivates parkin. Nature Medicine. 11: 1214-21. PMID 16227987 DOI: 10.1038/Nm1314  0.664
2005 Hemming ML, Selkoe DJ. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. The Journal of Biological Chemistry. 280: 37644-50. PMID 16154999 DOI: 10.1074/Jbc.M508460200  0.746
2005 Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/Jneurosci.4883-04.2005  0.656
2005 Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 44: 6513-25. PMID 15850385 DOI: 10.1021/Bi0476578  0.74
2005 Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nature Medicine. 11: 556-61. PMID 15834427 DOI: 10.1038/Nm1234  0.637
2005 Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2455-62. PMID 15758153 DOI: 10.1523/Jneurosci.4391-04.2005  0.646
2005 Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nature Neuroscience. 8: 79-84. PMID 15608634 DOI: 10.1038/Nn1372  0.602
2005 Chyung JH, Raper DM, Selkoe DJ. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. The Journal of Biological Chemistry. 280: 4383-92. PMID 15569674 DOI: 10.1074/Jbc.M409272200  0.806
2004 Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 44: 181-93. PMID 15450169 DOI: 10.1016/j.neuron.2004.09.010  0.589
2004 Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neuroscience Letters. 366: 320-5. PMID 15288443 DOI: 10.1016/j.neulet.2004.05.060  0.619
2004 Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/Bj20041081  0.322
2004 Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Purification and characterization of the human gamma-secretase complex. Biochemistry. 43: 9774-89. PMID 15274632 DOI: 10.1021/Bi0494976  0.718
2004 Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. The American Journal of Pathology. 165: 283-97. PMID 15215183 DOI: 10.1016/S0002-9440(10)63296-8  0.429
2004 Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein and Peptide Letters. 11: 213-28. PMID 15182223 DOI: 10.2174/0929866043407174  0.653
2004 Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K. A seed for Alzheimer amyloid in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4894-902. PMID 15152051 DOI: 10.1523/JNEUROSCI.0861-04.2004  0.466
2004 Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. The European Journal of Neuroscience. 19: 2839-46. PMID 15147317 DOI: 10.1111/j.1460-9568.2004.03389.x  0.593
2004 Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3370-8. PMID 15056716 DOI: 10.1523/JNEUROSCI.1633-03.2004  0.587
2004 Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. The American Journal of Pathology. 164: 1425-34. PMID 15039230 DOI: 10.1016/S0002-9440(10)63229-4  0.444
2004 Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry. 43: 323-33. PMID 14717586 DOI: 10.1021/Bi035748J  0.774
2004 Klyubin I, Walsh DM, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. P2-004 Anti-Aβ antibodies prevention block of long-term potentiation in the CA1 area of rat hippocampus in vivo by naturally produced Aβ oligomers Neurobiology of Aging. 25: S224-S225. DOI: 10.1016/S0197-4580(04)80752-8  0.564
2004 Walsh DM, Kylubin I, Cleary JP, Townsend TM, Shankar GM, Podlisny MB, Fadeeva JV, Anwyl R, Ashe KH, Rowan MJ, Selkoe DJ. P1-230 Natural, cell-derived Aβ oligomers: their production, biological activity and inhibition Neurobiology of Aging. 25: S161-S162. DOI: 10.1016/S0197-4580(04)80543-8  0.569
2004 Fadeeva JV, Walsh DM, Tang J, Luo Y, Citron M, Wasco W, Selkoe DJ. P1-218 Generation of the intracellular C-terminal domain of the APP family of proteins does not require β-secretase Neurobiology of Aging. 25: S158. DOI: 10.1016/S0197-4580(04)80531-1  0.554
2004 Townsend M, Podlisny M, Shankar G, Fadeeva J, Walsh D, Selkoe D. O4-03-04 Reversal of AB induced LTP deficits by compounds that inhibit AB oligomerization Neurobiology of Aging. 25: S78-S79. DOI: 10.1016/S0197-4580(04)80267-7  0.509
2004 Selkoe DJ, LaVoie M, Fraering P, Ostaszewski B, Ye W, Zheng B, Taylor Kimberly W, Wolfe M. S2-03-01 Presenilin as the active site of gamma-secretase, a novel intramembranous aspartyl protease Neurobiology of Aging. 25: S28. DOI: 10.1016/S0197-4580(04)80091-5  0.653
2003 Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 40: 1087-93. PMID 14687544 DOI: 10.1016/S0896-6273(03)00787-6  0.663
2003 Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiology of Disease. 14: 194-204. PMID 14572442 DOI: 10.1016/S0969-9961(03)00123-2  0.783
2003 Chyung JH, Selkoe DJ. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. The Journal of Biological Chemistry. 278: 51035-43. PMID 14525989 DOI: 10.1074/Jbc.M304989200  0.809
2003 Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. The Journal of Biological Chemistry. 278: 49874-81. PMID 14507911 DOI: 10.1074/Jbc.M309127200  0.309
2003 Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiology of Disease. 14: 10-8. PMID 13678662 DOI: 10.1016/S0969-9961(03)00044-5  0.38
2003 Ye CP, Selkoe DJ, Hartley DM. Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures. Neurobiology of Disease. 13: 177-90. PMID 12901832 DOI: 10.1016/S0969-9961(03)00068-8  0.38
2003 Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of Clinical Investigation. 112: 415-22. PMID 12897209 DOI: 10.1172/Jci18104  0.643
2003 Leissring MA, Lu A, Condron MM, Teplow DB, Stein RL, Farris W, Selkoe DJ. Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. The Journal of Biological Chemistry. 278: 37314-20. PMID 12867419 DOI: 10.1074/Jbc.M305627200  0.42
2003 LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. The Journal of Biological Chemistry. 278: 37213-22. PMID 12857757 DOI: 10.1074/Jbc.M303941200  0.776
2003 LaVoie MJ, Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. The Journal of Biological Chemistry. 278: 34427-37. PMID 12826675 DOI: 10.1074/Jbc.M302659200  0.666
2003 Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/Bi027375C  0.822
2003 Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 6382-7. PMID 12740439 DOI: 10.1073/Pnas.1037392100  0.788
2003 Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 37: 583-95. PMID 12597857 DOI: 10.1016/S0896-6273(03)00024-2  0.577
2003 Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 42: 137-44. PMID 12515548 DOI: 10.1021/bi026888g  0.667
2003 Walsh D, Hartley D, Selkoe D. The Many Faces of Aβ: Structures and Activity Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3: 277-291. DOI: 10.2174/1568013033483311  0.496
2002 Weiner HL, Selkoe DJ. Inflammation and therapeutic vaccination in CNS diseases. Nature. 420: 879-84. PMID 12490962 DOI: 10.1038/Nature01325  0.447
2002 Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochemical Society Transactions. 30: 552-7. PMID 12196135 DOI: 10.1042/BST0300552  0.622
2002 Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (New York, N.Y.). 297: 353-6. PMID 12130773 DOI: 10.1126/Science.1072994  0.469
2002 Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. The Journal of Biological Chemistry. 277: 35113-7. PMID 12130643 DOI: 10.1074/Jbc.M204446200  0.77
2002 Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. The American Journal of Pathology. 160: 1655-67. PMID 12000718 DOI: 10.1016/S0002-9440(10)61113-3  0.636
2002 Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nature Cell Biology. 4: E110-1; author reply. PMID 11988746 DOI: 10.1038/ncb0502-e110b  0.652
2002 Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416: 535-9. PMID 11932745 DOI: 10.1038/416535a  0.652
2002 Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proceedings of the National Academy of Sciences of the United States of America. 99: 2720-5. PMID 11867728 DOI: 10.1073/pnas.052436599  0.671
2002 Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ. Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. The Journal of Biological Chemistry. 277: 15069-75. PMID 11839734 DOI: 10.1074/jbc.M105375200  0.304
2002 Mori C, Spooner ET, Wisniewski KE, Wisniewski TM, Yamaguchi H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Aβ42 accumulation in Down syndrome brain Amyloid. 9: 88-102. DOI: 10.3109/13506120208995241  0.436
2002 Walsh DM, Kylubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Cell-derived Aβ oligomers: production, activity and inhibition Biochemical Society Transactions. 30: A56-A56. DOI: 10.1042/bst030a056  0.577
2001 Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. Dna and Cell Biology. 20: 705-11. PMID 11788048 DOI: 10.1089/10445490152717569  0.539
2001 Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. The Journal of Biological Chemistry. 276: 40288-92. PMID 11544248 DOI: 10.1074/jbc.C100447200  0.667
2001 Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 10273-8. PMID 11517335 DOI: 10.1073/Pnas.191118298  0.556
2001 Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 9110-5. PMID 11481478 DOI: 10.1073/Pnas.171300598  0.311
2001 Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (New York, N.Y.). 293: 263-9. PMID 11431533 DOI: 10.1126/Science.1060627  0.526
2001 Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. The Biochemical Journal. 355: 869-77. PMID 11311152 DOI: 10.1042/Bj3550869  0.647
2000 Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Annals of the New York Academy of Sciences. 920: 328-31. PMID 11193172 DOI: 10.1111/J.1749-6632.2000.Tb06943.X  0.482
2000 Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 223-6. PMID 11193154 DOI: 10.1111/J.1749-6632.2000.Tb06926.X  0.379
2000 Moore CL, Diehl TS, Selkoe DJ, Wolfe MS. Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors. Annals of the New York Academy of Sciences. 920: 197-205. PMID 11193150 DOI: 10.1111/j.1749-6632.2000.tb06922.x  0.373
2000 Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiology of Disease. 7: 673-81. PMID 11114265 DOI: 10.1006/nbdi.2000.0322  0.662
2000 Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nature Structural Biology. 7: 1095-9. PMID 11101888 DOI: 10.1038/81937  0.58
2000 Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization. The Biochemical Journal. 351: 509-16. PMID 11023838 DOI: 10.1042/Bj3510509  0.428
2000 Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 166-78. PMID 11019857 DOI: 10.3109/13506120009146831  0.574
2000 Moore CL, Leatherwood DD, Diehl TS, Selkoe DJ, Wolfe MS. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design. Journal of Medicinal Chemistry. 43: 3434-42. PMID 10978191 DOI: 10.1021/jm000100f  0.42
2000 Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 39: 10831-9. PMID 10978169 DOI: 10.1021/bi001048s  0.632
2000 Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9299-304. PMID 10922078 DOI: 10.1073/Pnas.97.16.9299  0.675
2000 Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. Journal of Neurochemistry. 75: 583-93. PMID 10899933 DOI: 10.1046/J.1471-4159.2000.0750583.X  0.674
2000 Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nature Cell Biology. 2: 428-34. PMID 10878808 DOI: 10.1038/35017062  0.68
2000 Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. The American Journal of Pathology. 156: 489-99. PMID 10666378 DOI: 10.1016/S0002-9440(10)64753-0  0.434
2000 Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. The Journal of Biological Chemistry. 275: 3173-8. PMID 10652302 DOI: 10.1074/jbc.275.5.3173  0.687
2000 Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme The Journal of Neuroscience. 20: 1657-1665. DOI: 10.1523/Jneurosci.20-05-01657.2000  0.631
2000 Esler WP, Diehl TS, Ostaszewski BL, Moore CL, Xia W, Kimberly WT, Selkoe DJ, Wolfe MS. Toward identification of gamma-secretase using transition-state analogue inhibitors Neurobiology of Aging. 21: 278. DOI: 10.1016/S0197-4580(00)83201-7  0.574
2000 Monsonego A, Maron R, Bar-Or A, Krieger JI, Selkoe D, Weiner HL. The role of T cell reactivity to A-beta amyloid peptide in the pathogenic processes associated with Alzheimer's disease Neurobiology of Aging. 21: 23. DOI: 10.1016/S0197-4580(00)82780-3  0.527
2000 Berezovska O, Jack CE, Aster JC, Wolfe MS, Selkoe DJ, Hyman BT. γ-Secretase inhibitors which have been shown to block Aβ production do not abolish Notch1 signaling Neurobiology of Aging. 21: 78. DOI: 10.1016/S0197-4580(00)82576-2  0.32
2000 Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhut JJ, Teplow DB. A de novo designed α-helical peptide forms amyloid fibrils which are not neurotoxic Neurobiology of Aging. 21: 77. DOI: 10.1016/S0197-4580(00)82568-3  0.566
2000 Selkoe DJ, Xia W, Taylor Kimberly W, Vekrellis K, Walsh D, Wolfe MS. Molecular basis of presenilin's role in APP processing Neurobiology of Aging. 21: 70. DOI: 10.1016/S0197-4580(00)82534-8  0.561
2000 Mori C, Wisniewski K, Wisniewski T, Saido TC, Selkoe DJ, Lemere CA. Intraneuronal Aβ42 immunoreactivity is inversely correlated with Alzheimer's disease pathology in down syndrome brain: A temporal study Neurobiology of Aging. 21: 121. DOI: 10.1016/S0197-4580(00)82344-1  0.381
2000 Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease Annals of Neurology. 48: 567-579. DOI: 10.1002/1531-8249(200010)48:4<567::Aid-Ana3>3.0.Co;2-W  0.555
1999 Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8876-84. PMID 10516307 DOI: 10.1523/Jneurosci.19-20-08876.1999  0.479
1999 Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry. 38: 11223-30. PMID 10471271 DOI: 10.1021/Bi991080Q  0.45
1999 Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. The Journal of Biological Chemistry. 274: 25945-52. PMID 10464339 DOI: 10.1074/Jbc.274.36.25945  0.649
1999 Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. The Journal of Biological Chemistry. 274: 18851-6. PMID 10383380 DOI: 10.1074/Jbc.274.27.18851  0.786
1999 Westermark P, Araki S, Benson MD, Cohen AS, Frangione B, Masters CL, Saraiva MJ, Sipe JD, Husby G, Kyle RA, Selkoe D. Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 6: 63-6. PMID 10211413 DOI: 10.3109/13506129908993290  0.384
1999 Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398: 513-7. PMID 10206644 DOI: 10.1038/19077  0.696
1999 Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 38: 4720-7. PMID 10200159 DOI: 10.1021/bi982562p  0.446
1999 Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons The Journal of Neuroscience. 19: 8876-8884. DOI: 10.1523/JNEUROSCI.19-20-08876.1999  0.539
1998 Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 37: 16465-71. PMID 9843412 DOI: 10.1021/Bi9816195  0.768
1998 Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry. 273: 32730-8. PMID 9830016 DOI: 10.1074/Jbc.273.49.32730  0.641
1998 Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. The Journal of Biological Chemistry. 273: 32322-31. PMID 9822712 DOI: 10.1074/Jbc.273.48.32322  0.466
1998 Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. Journal of the Neurological Sciences. 158: 15-23. PMID 9667772 DOI: 10.1016/S0022-510X(98)00106-3  0.433
1998 Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. The Journal of Biological Chemistry. 273: 12436-42. PMID 9575200 DOI: 10.1074/Jbc.273.20.12436  0.712
1998 Davies P, Resnick J, Resnick B, Gilman S, Growdon JH, Khachaturian ZS, Radebaugh TS, Roses AD, Selkoe DJ, Trojanowski JQ, Blass JP, Gibson GE, Sheu KFR, Blennow K, Delacourte A, et al. Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' Neurobiology of Aging. 19: 109-116. PMID 9558143 DOI: 10.1016/S0197-4580(98)00022-0  0.568
1998 Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry. 37: 3602-11. PMID 9521679 DOI: 10.1021/Bi972029U  0.395
1998 Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432 DOI: 10.1074/Jbc.273.6.3205  0.511
1998 Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 391: 339-40. PMID 9450743 DOI: 10.1038/34800  0.466
1997 Querfurth HW, Jiang J, Geiger JD, Selkoe DJ. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. Journal of Neurochemistry. 69: 1580-91. PMID 9326287 DOI: 10.1046/j.1471-4159.1997.69041580.x  0.363
1997 Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 8208-13. PMID 9223340 DOI: 10.1073/Pnas.94.15.8208  0.524
1997 Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/Nbdi.1997.0129  0.616
1997 Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89: 629-39. PMID 9160754 DOI: 10.1016/S0092-8674(00)80244-5  0.339
1997 Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 94: 5349-54. PMID 9144240 DOI: 10.1073/Pnas.94.10.5349  0.466
1997 Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/Jbc.272.12.7977  0.616
1997 Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878 DOI: 10.1074/Jbc.272.3.1896  0.526
1997 Yamazaki T, Koo EH, Selkoe DJ. Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1004-10. PMID 8994055 DOI: 10.1523/Jneurosci.17-03-01004.1997  0.524
1997 Yamazaki T, Koo EH, Selkoe DJ. Cell Surface Amyloid β-Protein Precursor Colocalizes with β1 Integrins at Substrate Contact Sites in Neural Cells The Journal of Neuroscience. 17: 1004-1010. DOI: 10.1523/JNEUROSCI.17-03-01004.1997  0.467
1996 Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiology of Disease. 3: 16-32. PMID 9173910 DOI: 10.1006/Nbdi.1996.0003  0.386
1996 Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483 DOI: 10.1007/Bf03401652  0.466
1996 Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. The Journal of Biological Chemistry. 271: 33623-31. PMID 8969231 DOI: 10.1074/Jbc.271.52.33623  0.415
1996 Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ. Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. The Journal of Biological Chemistry. 271: 32916-22. PMID 8955133 DOI: 10.1074/Jbc.271.51.32916  0.414
1996 Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9  0.354
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, ... Selkoe DJ, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/Nm1096-1146  0.696
1996 Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiology of Aging. 17: 653-9. PMID 8832640 DOI: 10.1016/0197-4580(96)00062-0  0.35
1996 Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American Journal of Pathology. 149: 1063-71. PMID 8780408  0.301
1996 Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 17: 171-9. PMID 8755488 DOI: 10.1016/S0896-6273(00)80290-1  0.466
1996 Yamazaki T, Koo EH, Selkoe DJ. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. Journal of Cell Science. 109: 999-1008. PMID 8743947  0.467
1996 Koo EH, Squazzo SL, Selkoe DJ, Koo CH. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. Journal of Cell Science. 109: 991-8. PMID 8743946  0.467
1996 Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, ... ... Selkoe D, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2: 864-70. PMID 8705854 DOI: 10.1038/Nm0896-864  0.393
1996 Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. The Journal of Biological Chemistry. 271: 8443-51. PMID 8626544 DOI: 10.1074/Jbc.271.14.8443  0.466
1996 Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127 DOI: 10.1111/J.1749-6632.1996.Tb34401.X  0.616
1996 Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C. Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation Amyloid. 3: 150-155. DOI: 10.3109/13506129609045514  0.466
1996 Walters J, Hung A, Thinakaran G, Sisodia S, Selkoe D, Haassl C. 388 Phosphorylation of ß-amyloid precursor protein at two distinct cellular locations Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80390-3  0.394
1996 Citron M, Xia W, Diehl T, Podlisny M, Sherrington R, Haass C, Seubert P, Hyslop P, Selkoe D. 320 Effect of presenilin mutations on BAPP processing in presenilin transfected cells Neurobiology of Aging. 17: S81. DOI: 10.1016/S0197-4580(96)80322-8  0.466
1996 Haass C, Walter J, Grünberg J, George-Hyslop PS, Selkoe D, Pesold B, Capell A. 150 Expression of the Presenilin proteins PS-1 and PS-2 in tissue culture cells Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80152-7  0.466
1996 Younkin S, Scheuner D, Song X, Eckman C, Citron M, Suzuki N, Bird T, Hardy J, Hutton M, Lannfelt L, Levy-Lahad E, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, ... ... Selkoe D, et al. 149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80151-5  0.43
1996 Younkin SG, Song XH, Scheuner D, Eckman C, Prada C, Jensen J, Lannfelt L, Hardy J, Tanzi R, Schellenberg G, Selkoe D, Suzuki N. The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein Biological Psychiatry. 39: 562. DOI: 10.1016/0006-3223(96)84161-8  0.415
1995 Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neuroscience Letters. 198: 52-6. PMID 8570096 DOI: 10.1016/0304-3940(95)11944-R  0.56
1995 Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2157-67. PMID 7891158 DOI: 10.1523/Jneurosci.15-03-02157.1995  0.524
1995 Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 6186-92. PMID 7890753 DOI: 10.1074/Jbc.270.11.6186  0.466
1995 Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/Jcb.128.4.537  0.616
1995 Querfurth HW, Wijsman EM, St George-Hyslop PH, Selkoe DJ. Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Research. Molecular Brain Research. 28: 319-37. PMID 7723630 DOI: 10.1016/0169-328X(94)00224-3  0.355
1995 Yamazaki T, Selkoe DJ, Koo EH. Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. The Journal of Cell Biology. 129: 431-42. PMID 7721945 DOI: 10.1083/Jcb.129.2.431  0.524
1995 Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. The Journal of Biological Chemistry. 270: 9564-70. PMID 7721886 DOI: 10.1074/Jbc.270.16.9564  0.524
1995 Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American Journal of Pathology. 146: 848-60. PMID 7717452  0.519
1995 Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical Journal. 311: 299-305. PMID 7575468 DOI: 10.1042/Bj3110299  0.557
1995 Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Medicine. 1: 1291-6. PMID 7489411 DOI: 10.1038/Nm1295-1291  0.466
1994 Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445 DOI: 10.1073/Pnas.91.4.1564  0.616
1994 Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 7104-8. PMID 8041753 DOI: 10.1073/Pnas.91.15.7104  0.524
1994 Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 17741-8. PMID 8021287  0.393
1994 Citron M, Vigo-Pelfrey C, Teplow DB, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe DJ. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proceedings of the National Academy of Sciences of the United States of America. 91: 11993-7. PMID 7991571 DOI: 10.1073/Pnas.91.25.11993  0.388
1994 Johnston J, Cowburn R, Wiehager B, Norgren S, Lannfelt L, Vigo-Pelfrey C, Schenk D, Citron M, Selkoe D, O'Neill C. Amyloid precursor protein expression and β-amyloid release in fibroblast cell lines obtained from family members with the Swedish APP670/671 mutation Neurobiology of Aging. 15: S71. DOI: 10.1016/0197-4580(94)92743-X  0.373
1993 Koo EH, Park L, Selkoe DJ. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 90: 4748-52. PMID 8506329 DOI: 10.1073/Pnas.90.10.4748  0.524
1993 Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. The Journal of Biological Chemistry. 268: 3021-4. PMID 8428976  0.393
1993 Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiology of Aging. 14: 571-3. PMID 8295660 DOI: 10.1016/0197-4580(93)90041-9  0.466
1993 Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 75: 1039-42. PMID 8261505 DOI: 10.1016/0092-8674(93)90312-E  0.466
1993 Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Annals of the New York Academy of Sciences. 695: 109-16. PMID 8239267 DOI: 10.1111/J.1749-6632.1993.Tb23037.X  0.544
1993 Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807  0.51
1992 Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (New York, N.Y.). 255: 728-30. PMID 1738847 DOI: 10.1126/Science.1738847  0.378
1992 Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiology of Aging. 13: 421-34. PMID 1625772 DOI: 10.1016/0197-4580(92)90117-G  0.555
1992 Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500A0  0.68
1992 Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360: 672-4. PMID 1465129 DOI: 10.1038/360672A0  0.565
1992 Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry. 31: 10716-23. PMID 1420187 DOI: 10.1021/Bi00159A011  0.379
1992 Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654 DOI: 10.1073/Pnas.89.20.9439  0.682
1991 Podlisny MB, Tolan DR, Selkoe DJ. Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease American Journal of Pathology. 138: 1423-1435. PMID 1905108  0.302
1991 Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3783-93. PMID 1744690 DOI: 10.1523/Jneurosci.11-12-03783.1991  0.466
1991 Haass C, Hung A, Selkoe D. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion The Journal of Neuroscience. 11: 3783-3793. DOI: 10.1523/JNEUROSCI.11-12-03783.1991  0.495
1990 Podlisny MB, Mammen AL, Schlossmacher MG, Palmert MR, Younkin SG, Selkoe DJ. Detection of soluble forms of the beta-amyloid precursor protein in human plasma. Biochemical and Biophysical Research Communications. 167: 1094-101. PMID 2138892 DOI: 10.1016/0006-291X(90)90635-Z  0.441
1990 Podlisny M, Ostaszewski B, Tolan D, Selkoe D. COMPLETE HOMOLOGY OF AMYLOID PRECURSOR PROTEIN (APP) IN MONKEY AND HUMAN SUPPORTS A PRIMATE MODEL OF β-AMYLOIDOSIS Journal of Neuropathology and Experimental Neurology. 49: 308. DOI: 10.1097/00005072-199005000-00149  0.362
1989 Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 32: 715-20. PMID 2689908 DOI: 10.1016/0306-4522(89)90292-3  0.787
1989 Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG. Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochemical and Biophysical Research Communications. 165: 182-8. PMID 2480122 DOI: 10.1016/0006-291X(89)91052-8  0.308
1989 Podlisny M, Gronbeck A, Tolan D, Olteradorf T, Selkoe D. STUDIES OF THE PROCESSING OF β-AMYLOID PRECURSOR PROTEIN (βAPP) IN HUMAN, MONKEY AND RODENT BRAIN AND IN cDNA-TRANSFECTED CELLS Journal of Neuropathology and Experimental Neurology. 48: 353. DOI: 10.1097/00005072-198905000-00162  0.366
1988 Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 52: 487-501. PMID 3257719 DOI: 10.1016/0092-8674(88)90462-X  0.772
1988 Joachim CL, Duffy LK, Morris JH, Selkoe DJ. Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging. Brain Research. 474: 100-11. PMID 3214703 DOI: 10.1016/0006-8993(88)90673-7  0.455
1988 Cork LC, Powers RE, Selkoe DJ, Davies P, Geyer JJ, Price DL. Neurofibrillary tangles and senile plaques in aged bears. Journal of Neuropathology and Experimental Neurology. 47: 629-41. PMID 3171607 DOI: 10.1097/00005072-198811000-00006  0.355
1988 Nukina N, Kosik KS, Selkoe DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neuroscience Letters. 87: 240-6. PMID 3132653 DOI: 10.1016/0304-3940(88)90455-7  0.696
1988 Duffy LK, Berman‐Podlisny M, Rasool CG, Walsh RL, Selkoe DJ. Studies on the Relationship between Plasma Proteins and Amyloid Fibrils Found in Alzheimer's Disease Annals of the New York Academy of Sciences. 529: 233-235. DOI: 10.1111/J.1749-6632.1988.Tb51468.X  0.403
1988 ABRAHAM CR, SELKOE DJ, POTTER H. ??1-ANTICHYMOTRYPSIN IN BRAIN AGING AND DISEASE Alzheimer Disease & Associated Disorders. 2: 259. DOI: 10.1097/00002093-198802030-00108  0.727
1987 Kirschner DA, Inouye H, Duffy LK, Sinclair A, Lind M, Selkoe DJ. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proceedings of the National Academy of Sciences of the United States of America. 84: 6953-7. PMID 3477820 DOI: 10.1073/Pnas.84.19.6953  0.387
1987 Nukina N, Kosik KS, Selkoe DJ. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proceedings of the National Academy of Sciences of the United States of America. 84: 3415-9. PMID 3106969 DOI: 10.1097/00002093-198701040-00025  0.671
1987 Joachim CL, Morris JH, Selkoe DJ, Kosik KS. Tau epitopes are incorporated into a range of lesions in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology. 46: 611-22. PMID 2443617 DOI: 10.1097/00005072-198711000-00001  0.59
1987 Neve RL, Selkoe DJ, Kurnit DM, Kosik KS. A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle. Brain Research. 387: 193-6. PMID 2431745 DOI: 10.1016/0169-328X(86)90011-2  0.553
1987 Duffy LK, Abraham CR, Berman‐Podlisny M, Walsh RL, Selkoe DJ. HPLC Analysis of Proteins from Alzheimer Paired Helical Filaments Annals of the New York Academy of Sciences. 494: 369-372. DOI: 10.1111/J.1749-6632.1987.Tb29575.X  0.723
1987 Joachim CL, Duffy LK, Selkoe DJ. ISOLATION AND CHARACTERIZATION OF CEREBROVASCULAR AMYLOID (CVA) PROTEINS IN ALZHEIMERʼS DISEASE Journal of Neuropathology and Experimental Neurology. 46: 396. DOI: 10.1097/00005072-198705000-00199  0.392
1987 Nukina N, Kosik K, Selkoe D. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to cross-reaction with tau protein Alzheimer Disease & Associated Disorders. 1: 268. DOI: 10.1097/00002093-198701040-00025  0.632
1987 Rasool C, Abraham C, Anderton B, Haugh M, Kahn J, Selkoe D. Alzheimerʼs disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies Alzheimer Disease & Associated Disorders. 1: 267. DOI: 10.1097/00002093-198701040-00020  0.654
1987 Kosik K, Joachim C, Selkoe D. Microtubule-associated protein tau (? ) is a major antigenic component of paired helical filaments in Alzheimer disease Alzheimer Disease & Associated Disorders. 1: 203. DOI: 10.1097/00002093-198701030-00022  0.517
1986 Selkoe DJ, Abraham CR. Isolation of paired helical filaments and amyloid fibers from human brain. Methods in Enzymology. 134: 388-404. PMID 3821571 DOI: 10.1016/0076-6879(86)34105-3  0.678
1986 Selkoe DJ, Abraham CR, Podlisny MB, Duffy LK. Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. Journal of Neurochemistry. 46: 1820-34. PMID 3517233 DOI: 10.1111/J.1471-4159.1986.Tb08501.X  0.752
1986 Kirschner DA, Abraham C, Selkoe DJ. X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation. Proceedings of the National Academy of Sciences of the United States of America. 83: 503-7. PMID 3455785 DOI: 10.1073/Pnas.83.2.503  0.678
1986 Kosik KS, Bakalis S, Galibert L, Selkoe DJ, Duffy LK. Age-related modifications of MAP-2. Annals of the New York Academy of Sciences. 466: 420-2. PMID 2873778 DOI: 10.1111/J.1749-6632.1986.Tb38412.X  0.459
1986 Kosik KS, Bakalis SF, Selkoe DJ, Pierce MW, Duffy LK. High molecular weight microtubule-associated proteins: Purification by electro-elution and amino acid compositions Journal of Neuroscience Research. 15: 543-551. PMID 2873254 DOI: 10.1002/Jnr.490150411  0.505
1986 Kosik KS, Joachim CL, Selkoe DJ. Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 83: 4044-8. PMID 2424016 DOI: 10.1097/00002093-198701030-00022  0.587
1986 Perry G, Selkoe DJ, Block BR, Stewart D, Autilio-Gambetti L, Gambetti P. Electron microscopic localization of Alzheimer neurofibrillary tangle components recognized by an antiserum to paired helical filaments. Journal of Neuropathology and Experimental Neurology. 45: 161-8. PMID 2419516 DOI: 10.1097/00005072-198603000-00006  0.317
1986 Kosik KS, Nukina N, Ihara V, Selkoe DJ, Pope A. TAU-SPECIFIC MONOCLONAL AND POLYCLONAL ANTIBODIES SUGGEST THAT TAU IS A MAJOR ANTIGENIC COMPONENT OF ALZHEIMER NEUROFIBRILLARY TANGLES (NFT) Journal of Neuropathology and Experimental Neurology. 45: 378. DOI: 10.1097/00005072-198605000-00192  0.665
1986 Selkoe D, Podlisny M, Galibert L, Abraham C, Duffy L. PRODUCTION OF AMYLOID-SPECIFIC ANTIBODIES TO LOW MOLECULAR WEIGHT PROTEINS ISOLATED FROM ALZHEIMERʼS DISEASE (AD) BRAIN Journal of Neuropathology and Experimental Neurology. 45: 360. DOI: 10.1097/00005072-198605000-00139  0.732
1986 Nukina N, Kosik K, Selkoe D, Ihara Y. TAU PROTEIN IS INTEGRATED INTO PAIRED HELICAL FILAMENTS (PHF) IN ALZHEIMERʼS DISEASE (AD) Journal of Neuropathology and Experimental Neurology. 45: 338. DOI: 10.1097/00005072-198605000-00074  0.732
1985 Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Kosik KS, Duffy LK. Paired helical filaments in human neurons: relationship to neurofilaments Annals of the New York Academy of Sciences. 455: 583-596. PMID 3936387 DOI: 10.1111/J.1749-6632.1985.Tb50438.X  0.731
1985 Kosik KS, McCluskey AH, Walsh FX, Selkoe DJ. Axonal transport of cytoskeletal proteins in aluminum toxicity. Aluminum toxicity and axonal transport. Neurochemical Pathology. 3: 99-108. PMID 2413406 DOI: 10.1007/bf02834283  0.502
1985 SELKOE DJ, ABRAHAM C, RASOOL CG, McCLUSKEY A, DUFFY LK. Production and Characterization of Monoclonal Antibodies to Alzheimer Paired Helical Filaments Annals of the New York Academy of Sciences. 455: 774-778. DOI: 10.1111/J.1749-6632.1985.Tb50472.X  0.697
1984 Rasool CG, Abraham C, Anderton BH, Haugh M, Kahn J, Selkoe DJ. Alzheimer's disease: immunoreactivity of neurofibrillary tangles with anti-neurofilament and anti-paired helical filament antibodies. Brain Research. 310: 249-60. PMID 6207891 DOI: 10.1016/0006-8993(84)90148-3  0.678
1984 Kosik KS, Duffy LK, Dowling MM, Abraham C, McCluskey A, Selkoe DJ. Microtubule-associated protein 2: Monoclonal antibodies demonstrate the selective incorporation of certain epitopes into Alzheimer neurofibrillary tangles Proceedings of the National Academy of Sciences of the United States of America. 81: 7941-7945. PMID 6083566 DOI: 10.1073/Pnas.81.24.7941  0.761
1984 Selkoe DJ, Abraham C, Rasool CG, McCluskey A, Duffy LK. 161 MONOCLONAL ANTIBODIES TO ALZHEIMER PAIRED HELICAL FILAMENTS PRODUCED BY RAT-MOUSE HYBRIDOMAS Journal of Neuropathology and Experimental Neurology. 43: 346. DOI: 10.1097/00005072-198405000-00167  0.694
1983 Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 304: 727-30. PMID 6350889 DOI: 10.1038/304727A0  0.78
1983 Kosik KS, Bradley WG, Good PF, Rasool CG, Selkoe DJ. Cholinergic function in lumbar aluminum myelopathy. Journal of Neuropathology and Experimental Neurology. 42: 365-75. PMID 6190994 DOI: 10.1097/00005072-198307000-00001  0.497
1983 Selkoe D, Abraham C, Ihara Y, Pope A. 105 ANTIBODIES TO THE FAIL TO REACT WITH NEUROFILAMENTS AND OTHER NORMAL PROTEINS Journal of Neuropathology and Experimental Neurology. 42: 340. DOI: 10.1097/00005072-198305000-00112  0.725
1982 Kosik KS, Gilbert JM, Selkoe DJ, Strocchi P. Characterization of postmortem human brain proteins by two-dimensional gel electrophoresis. Journal of Neurochemistry. 39: 1529-38. PMID 7142987 DOI: 10.1111/j.1471-4159.1982.tb07985.x  0.517
1982 Selkoe DJ, Salazar FJ, Abraham C, Kosik KS. Huntington's disease: changes in striatal proteins reflect astrocytic gliosis. Brain Research. 245: 117-25. PMID 6214299 DOI: 10.1016/0006-8993(82)90344-4  0.747
1982 Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proceedings of the National Academy of Sciences of the United States of America. 79: 6070-4. PMID 6136967 DOI: 10.1073/Pnas.79.19.6070  0.748
1982 Selkoe DJ, Ihara Y, Salazar FJ. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (New York, N.Y.). 215: 1243-5. PMID 6120571 DOI: 10.1126/Science.6120571  0.531
1982 Kosik KS, Rasool C, Bradley WG, Selkoe DJ. INCREASED RATE OF ACCUMULATION OF CHAT PROXIMAL TO A SCIATIC NERVE LIGATURE IN A13+-TREATED RABBITS Journal of Neuropathology and Experimental Neurology. 41: 361. DOI: 10.1097/00005072-198205000-00069  0.452
1982 Selkoe DJ, Abraham C, Ihara Y. CROSSLINKING OF ALZHEIMER PAIRED HELICAL FILAMENTS Journal of Neuropathology and Experimental Neurology. 41: 354. DOI: 10.1097/00005072-198205000-00048  0.752
1981 Selkoe DJ, Kosik KS. Alzheimer's Disease in Twins Archives of Neurology. 38: 785-785. DOI: 10.1001/archneur.1981.00510120085021  0.54
1979 Liem RK, Selkoe DJ, Yen SH, Salomon G, Shelanski ML. New insights on the composition of neurofilaments. Research Publications - Association For Research in Nervous and Mental Disease. 57: 145-52. PMID 419331  0.643
1979 Selkoe DJ, Liem RK, Yen SH, Shelanski ML. Biochemical and immunological characterization of neurofilaments in experimental neurofibrillary degeneration induced by aluminum. Brain Research. 163: 235-52. PMID 371751 DOI: 10.1016/0006-8993(79)90352-4  0.669
1978 Selkoe DJ, Luckenbill-Edds L, Shelanski ML. Effects of neurotoxic industrial solvents on cultured neuroblastoma cells: methyl n-butyl ketone, n-hexane and derivatives. Journal of Neuropathology and Experimental Neurology. 37: 768-89. PMID 739276 DOI: 10.1097/00005072-197811000-00005  0.537
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