| Year |
Citation |
Score |
| 2024 |
Liu L, Saba A, Pascual JR, Miller MB, Hennessey EL, Lott IT, Brickman AM, Wilcock DM, Harp JP, Schmitt FA, Selkoe DJ, Chhatwal JP, Head E. Lecanemab and Vascular-Amyloid Deposition in Brains of People With Down Syndrome. Jama Neurology. PMID 39158850 DOI: 10.1001/jamaneurol.2024.2579 |
0.345 |
|
| 2024 |
Schultz SA, Liu L, Schultz AP, Fitzpatrick CD, Levin R, Bellier JP, Shirzadi Z, Joseph-Mathurin N, Chen CD, Benzinger TLS, Day GS, Farlow MR, Gordon BA, Hassenstab JJ, Jack CR, ... ... Selkoe DJ, et al. γ-Secretase activity, clinical features, and biomarkers of autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analysis of the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet. Neurology. PMID 39074479 DOI: 10.1016/S1474-4422(24)00236-9 |
0.511 |
|
| 2024 |
Liu L, Schultz SA, Saba A, Yang HS, Li A, Selkoe DJ, Chhatwal JP. The pathogenicity of variants is tied to Aβ production and homology to . Biorxiv : the Preprint Server For Biology. PMID 38979391 DOI: 10.1101/2024.06.22.600217 |
0.321 |
|
| 2024 |
White AJ, Clark KA, Alexander KD, Ramalingam N, Young-Pearse TL, Dettmer U, Selkoe DJ, Ho GPH. A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons. Npj Parkinson's Disease. 10: 107. PMID 38773105 DOI: 10.1038/s41531-024-00725-y |
0.794 |
|
| 2024 |
Bellier JP, Román Viera AM, Christiano C, Anzai JAU, Moreno S, Campbell EC, Godwin L, Li A, Chen AY, Alam S, Saba A, Yoo HB, Yang HS, Chhatwal JP, Selkoe DJ, et al. Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy. Biorxiv : the Preprint Server For Biology. PMID 38746192 DOI: 10.1101/2024.05.01.591892 |
0.329 |
|
| 2024 |
Selkoe DJ. The advent of Alzheimer treatments will change the trajectory of human aging. Nature Aging. 4: 453-463. PMID 38641654 DOI: 10.1038/s43587-024-00611-5 |
0.307 |
|
| 2024 |
Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Author Correction: Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. Npj Parkinson's Disease. 10: 57. PMID 38472218 DOI: 10.1038/s41531-024-00675-5 |
0.79 |
|
| 2024 |
Nuber S, Zhang X, McCaffery TD, Moors TE, Adom MA, Hahn WN, Martin D, Ericsson M, Tripathi A, Dettmer U, Svenningsson P, Selkoe DJ. Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson's disease phenotypes. Npj Parkinson's Disease. 10: 47. PMID 38424059 DOI: 10.1038/s41531-024-00662-w |
0.8 |
|
| 2023 |
Bellier JP, Cai Y, Alam SM, Wiederhold T, Aiello A, Vogelgsang JS, Berretta S, Chhatwal JP, Selkoe DJ, Liu L. Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38041855 DOI: 10.1002/alz.13557 |
0.355 |
|
| 2023 |
Ramalingam N, Brontesi L, Jin SX, Selkoe DJ, Dettmer U. Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models. Embo Reports. e57145. PMID 37870370 DOI: 10.15252/embr.202357145 |
0.808 |
|
| 2023 |
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E. Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37438872 DOI: 10.1002/alz.13382 |
0.322 |
|
| 2023 |
Jin M, Wei Z, Ramalingam N, Xiao M, Xu A, Yu X, Song Q, Liu W, Zhao J, Zhang D, Selkoe DJ, Li S. Activation of β-adrenergic receptors prevents AD-type synaptotoxicity via epigenetic mechanisms. Molecular Psychiatry. PMID 37365243 DOI: 10.1038/s41380-023-02145-5 |
0.711 |
|
| 2023 |
Stern AM, Yang Y, Jin S, Yamashita K, Meunier AL, Liu W, Cai Y, Ericsson M, Liu L, Goedert M, Scheres SHW, Selkoe DJ. Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer's disease brains. Neuron. PMID 37167969 DOI: 10.1016/j.neuron.2023.04.007 |
0.378 |
|
| 2023 |
Young-Pearse TL, Lee H, Hsieh YC, Chou V, Selkoe DJ. Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer's disease. Trends in Neurosciences. PMID 37019812 DOI: 10.1016/j.tins.2023.03.005 |
0.648 |
|
| 2023 |
Stern AM, Van Pelt KL, Liu L, Anderson AK, Ostaszewski B, Mapstone M, O'Bryant S, Petersen ME, Christian BT, Handen BL, Selkoe DJ, Schmitt F, Head E. Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts. Medrxiv : the Preprint Server For Health Sciences. PMID 36945447 DOI: 10.1101/2023.03.10.23287109 |
0.794 |
|
| 2023 |
Ho GPH, Wilkie EC, White AJ, Selkoe DJ. Palmitoylation of the Parkinson's disease-associated protein synaptotagmin-11 links its turnover to α-synuclein homeostasis. Science Signaling. 16: eadd7220. PMID 36787382 DOI: 10.1126/scisignal.add7220 |
0.302 |
|
| 2023 |
Ramalingam N, Jin SX, Moors TE, Fonseca-Ornelas L, Shimanaka K, Lei S, Cam HP, Watson AH, Brontesi L, Ding L, Hacibaloglu DY, Jiang H, Choi SJ, Kanter E, Liu L, ... ... Selkoe DJ, et al. Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity. Npj Parkinson's Disease. 9: 4. PMID 36646701 DOI: 10.1038/s41531-023-00444-w |
0.8 |
|
| 2023 |
Xu H, Rajsombath MM, Weikop P, Selkoe DJ. Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. Embo Molecular Medicine. 15: e17061. PMID 36629339 DOI: 10.15252/emmm.202217061 |
0.64 |
|
| 2022 |
Fonseca-Ornelas L, Stricker JMS, Soriano-Cruz S, Weykopf B, Dettmer U, Muratore CR, Scherzer CR, Selkoe DJ. Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons. Npj Parkinson's Disease. 8: 118. PMID 36114228 DOI: 10.1038/s41531-022-00380-1 |
0.79 |
|
| 2022 |
Jin SX, Liu L, Li S, Meunier AL, Selkoe DJ. Aβ oligomers from human brain impair mossy fiber LTP in CA3 of hippocampus, but activating cAMP-PKA and cGMP-PKG prevents this. Neurobiology of Disease. 172: 105816. PMID 35820646 DOI: 10.1016/j.nbd.2022.105816 |
0.301 |
|
| 2022 |
Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neves E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, ... ... Selkoe DJ, et al. Correction to: A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 35792968 DOI: 10.1007/s13311-022-01268-x |
0.765 |
|
| 2022 |
Liu L, Cai Y, Lauro BM, Meunier AL, Chhatwal J, Selkoe DJ. Generation and application of semi-synthetic p-Tau181 calibrator for immunoassay calibration. Biochemical and Biophysical Research Communications. 611: 85-90. PMID 35483223 DOI: 10.1016/j.bbrc.2022.04.077 |
0.303 |
|
| 2022 |
Nuber S, Chung CY, Tardiff DF, Bechade PA, McCaffery TD, Shimanaka K, Choi J, Chang B, Raja W, Neve E, Burke C, Jiang X, Xu P, Khurana V, Dettmer U, ... ... Selkoe DJ, et al. A Brain-Penetrant Stearoyl-CoA Desaturase Inhibitor Reverses α-Synuclein Toxicity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 35445353 DOI: 10.1007/s13311-022-01199-7 |
0.79 |
|
| 2022 |
Liu L, Lauro BM, He A, Lee H, Bhattarai S, Wolfe MS, Bennett DA, Karch CM, Young-Pearse T, Selkoe DJ. Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35278341 DOI: 10.1002/alz.12646 |
0.679 |
|
| 2022 |
Stern AM, Liu L, Jin S, Liu W, Meunier AL, Ericsson M, Miller MB, Batson M, Sun T, Kathuria S, Reczek D, Pradier L, Selkoe DJ. A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer's disease brain. Brain : a Journal of Neurology. PMID 35084489 DOI: 10.1093/brain/awac023 |
0.393 |
|
| 2021 |
Liu L, Kwak H, Lawton TL, Jin SX, Meunier AL, Dang Y, Ostaszewski B, Pietras AC, Stern AM, Selkoe DJ. An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34550630 DOI: 10.1002/alz.12457 |
0.398 |
|
| 2021 |
Lagomarsino VN, Pearse RV, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, ... ... Selkoe DJ, et al. Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors. Neuron. PMID 34473944 DOI: 10.1016/j.neuron.2021.08.003 |
0.676 |
|
| 2021 |
Glajch KE, Moors TE, Chen Y, Bechade PA, Nam AY, Rajsombath MM, McCaffery TD, Dettmer U, Weihofen A, Hirst WD, Selkoe DJ, Nuber S. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326260 DOI: 10.1073/pnas.2103425118 |
0.789 |
|
| 2021 |
Fonseca-Ornelas L, Viennet T, Rovere M, Jiang H, Liu L, Nuber S, Ericsson M, Arthanari H, Selkoe DJ. Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson's disease. Cell Reports. 36: 109333. PMID 34233191 DOI: 10.1016/j.celrep.2021.109333 |
0.304 |
|
| 2021 |
Liu L, Lauro BM, Wolfe MS, Selkoe DJ. Hydrophilic loop 1 of Presenilin-1 and the APP GxxxG transmembrane motif regulate γ-secretase function in generating Alzheimer-causing Aβ peptides. The Journal of Biological Chemistry. 100393. PMID 33571524 DOI: 10.1016/j.jbc.2021.100393 |
0.398 |
|
| 2020 |
Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nature Communications. 11: 6024. PMID 33247134 DOI: 10.1038/s41467-020-19543-w |
0.524 |
|
| 2020 |
Ho GPH, Ramalingam N, Imberdis T, Wilkie EC, Dettmer U, Selkoe DJ. Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33103814 DOI: 10.1002/mds.28346 |
0.799 |
|
| 2020 |
Nuber S, Nam AY, Rajsombath MM, Cirka H, Hronowski X, Wang J, Hodgetts K, Kalinichenko LS, Müller CP, Lambrecht V, Winkler J, Weihofen A, Imberdis T, Dettmer U, Fanning S, ... Selkoe DJ, et al. A stearoyl-CoA desaturase inhibitor prevents multiple Parkinson's disease-phenotypes in α-synuclein mice. Annals of Neurology. PMID 32996158 DOI: 10.1002/ana.25920 |
0.786 |
|
| 2020 |
Lauwers E, Lalli G, Brandner S, Collinge J, Compernolle V, Duyckaerts C, Edgren G, Haïk S, Hardy J, Helmy A, Ivinson AJ, Jaunmuktane Z, Jucker M, Knight R, Lemmens R, ... ... Selkoe DJ, et al. Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet. Neurology. 19: 872-878. PMID 32949547 DOI: 10.1016/S1474-4422(20)30238-6 |
0.424 |
|
| 2020 |
Terry-Kantor E, Tripathi A, Imberdis T, LaVoie ZM, Ho GPH, Selkoe D, Fanning S, Ramalingam N, Dettmer U. Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor. International Journal of Molecular Sciences. 21. PMID 32707907 DOI: 10.3390/ijms21155193 |
0.8 |
|
| 2020 |
Fanning S, Selkoe D, Dettmer U. Vesicle trafficking and lipid metabolism in synucleinopathy. Acta Neuropathologica. PMID 32607605 DOI: 10.1007/s00401-020-02177-z |
0.81 |
|
| 2020 |
Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J, Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. The Journal of Prevention of Alzheimer's Disease. 7: 146-151. PMID 32463066 DOI: 10.14283/jpad.2020.24 |
0.445 |
|
| 2020 |
Selkoe DJ. Editorial: A Is for Amyloid. The Journal of Prevention of Alzheimer's Disease. 7: 140-141. PMID 32463063 DOI: 10.14283/jpad.2020.27 |
0.305 |
|
| 2020 |
Sanderson JB, De S, Jiang H, Rovere M, Jin M, Zaccagnini L, Hays Watson A, De Boni L, Lagomarsino VN, Young-Pearse TL, Liu X, Pochapsky TC, Hyman BT, Dickson DW, Klenerman D, ... Selkoe DJ, et al. Analysis of α-synuclein species enriched from cerebral cortex of humans with sporadic dementia with Lewy bodies. Brain Communications. 2: fcaa010. PMID 32280944 DOI: 10.1093/braincomms/fcaa010 |
0.807 |
|
| 2020 |
Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003 |
0.632 |
|
| 2020 |
Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aβ42 decrease with age, whereas NT1 tau and NfL increase. Alzheimer's Research & Therapy. 12: 27. PMID 32192521 DOI: 10.1186/S13195-020-00593-7 |
0.598 |
|
| 2020 |
Li S, Selkoe DJ. A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Ab oligomers from Alzheimer brain. Journal of Neurochemistry. PMID 32180217 DOI: 10.1111/jnc.15007 |
0.43 |
|
| 2020 |
Fanning S, Selkoe D, Dettmer U. Parkinson's disease: proteinopathy or lipidopathy? Npj Parkinson's Disease. 6: 3. PMID 31909184 DOI: 10.1038/s41531-019-0103-7 |
0.796 |
|
| 2019 |
Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Frontiers in Neuroscience. 13: 1208. PMID 31849573 DOI: 10.3389/Fnins.2019.01208 |
0.561 |
|
| 2019 |
Wei Z, Meng X, El Fatimy R, Sun B, Mai D, Zhang J, Arora R, Zeng A, Xu P, Qu S, Krichevsky AM, Selkoe DJ, Li S. Environmental enrichment prevents Aβ oligomer-induced synaptic dysfunction through mirna-132 and hdac3 signaling pathways. Neurobiology of Disease. 104617. PMID 31669733 DOI: 10.1016/j.nbd.2019.104617 |
0.346 |
|
| 2019 |
Imberdis T, Negri J, Ramalingam N, Terry-Kantor E, Ho GPH, Fanning S, Stirtz G, Kim TE, Levy OA, Young-Pearse TL, Selkoe D, Dettmer U. Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31548371 DOI: 10.1073/Pnas.1903216116 |
0.803 |
|
| 2019 |
Mengel D, Liu L, Yamamoto R, Zülow S, Deuschl C, Hermann DM, Zerr I, Selkoe DJ, Dodel R. A novel V272D presenilin mutation associated with logopenia, disorientation, and apraxia in an autosomal-dominant Alzheimer's disease family. Neurobiology of Aging. PMID 31500908 DOI: 10.1016/J.Neurobiolaging.2019.07.002 |
0.451 |
|
| 2019 |
Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ. Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31416794 DOI: 10.1016/J.Jalz.2019.06.3918 |
0.515 |
|
| 2019 |
Selkoe DJ. Early network dysfunction in Alzheimer's disease. Science (New York, N.Y.). 365: 540-541. PMID 31395769 DOI: 10.1126/science.aay5188 |
0.32 |
|
| 2019 |
Selkoe D. β-secretase inhibitors for Alzheimer's disease: heading in the wrong direction? Lancet Neurology. 18: 624-626. PMID 31202466 DOI: 10.1016/S1474-4422(19)30202-9 |
0.353 |
|
| 2019 |
Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Target Engagement in an Alzheimer Trial: Crenezumab Lowers Aβ Oligomers in CSF. Annals of Neurology. PMID 31168802 DOI: 10.1002/ana.25513 |
0.641 |
|
| 2019 |
Selkoe DJ. Alzheimer disease and aducanumab: adjusting our approach. Nature Reviews. Neurology. PMID 31138932 DOI: 10.1038/s41582-019-0205-1 |
0.38 |
|
| 2019 |
Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain. Brain : a Journal of Neurology. 142: 1441-1457. PMID 31032851 DOI: 10.1093/Brain/Awz066 |
0.701 |
|
| 2019 |
Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor. The Journal of Cell Biology. PMID 30626721 DOI: 10.1083/Jcb.201806205 |
0.506 |
|
| 2019 |
Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ. P1-218: A NOVEL CELLULAR COMPLEX OF BACE1 AND γ-SECRETASE SEQUENTIALLY GENERATES Aβ FROM APP Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.773 |
0.422 |
|
| 2018 |
Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, ... ... Selkoe D, et al. Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment. Molecular Cell. PMID 30527540 DOI: 10.1016/J.Molcel.2018.11.028 |
0.803 |
|
| 2018 |
Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30419228 DOI: 10.1016/J.Jalz.2018.09.010 |
0.785 |
|
| 2018 |
Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ. Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathologica Communications. 6: 121. PMID 30409172 DOI: 10.1186/S40478-018-0626-X |
0.532 |
|
| 2018 |
Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ. Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 100: 75-90.e5. PMID 30308173 DOI: 10.1016/j.neuron.2018.09.014 |
0.792 |
|
| 2018 |
Selkoe DJ. Light at the End of the Amyloid Tunnel. Biochemistry. PMID 30272957 DOI: 10.1021/acs.biochem.8b00985 |
0.309 |
|
| 2018 |
Zhao J, Li A, Rajsombath M, Dang Y, Selkoe DJ, Li S. Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region. Iscience. 6: 138-150. PMID 30240608 DOI: 10.1016/j.isci.2018.07.018 |
0.336 |
|
| 2018 |
Xu H, Rajsombath MM, Weikop P, Selkoe DJ. Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β. Embo Molecular Medicine. PMID 30093491 DOI: 10.15252/emmm.201808931 |
0.677 |
|
| 2018 |
Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease. Nature Communications. 9: 2676. PMID 29992960 DOI: 10.1038/S41467-018-05068-W |
0.8 |
|
| 2018 |
El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathologica. PMID 29982852 DOI: 10.1007/S00401-018-1880-5 |
0.747 |
|
| 2018 |
Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. International Journal of Molecular Sciences. 19. PMID 29495441 DOI: 10.3390/Ijms19030663 |
0.821 |
|
| 2017 |
Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, ... ... Selkoe DJ, et al. Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Stem Cell Reports. PMID 29153990 DOI: 10.1016/J.Stemcr.2017.10.015 |
0.82 |
|
| 2017 |
Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D. Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells. Human Molecular Genetics. 26: 3466-3481. PMID 28911198 DOI: 10.1093/hmg/ddx227 |
0.8 |
|
| 2017 |
Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, ... ... Selkoe DJ, et al. β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease. Science (New York, N.Y.). 357: 891-898. PMID 28860381 DOI: 10.1126/Science.Aaf3934 |
0.725 |
|
| 2017 |
Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, et al. A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 28734051 DOI: 10.1002/Mds.27090 |
0.331 |
|
| 2017 |
Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Developmental Biology. PMID 28284905 DOI: 10.1016/J.Ydbio.2017.03.007 |
0.702 |
|
| 2017 |
Bolduc DM, Selkoe DJ, Wolfe MS. Enzymatic Assays for Studying Intramembrane Proteolysis. Methods in Enzymology. 584: 295-308. PMID 28065268 DOI: 10.1016/bs.mie.2016.10.026 |
0.375 |
|
| 2017 |
Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 152-163. PMID 28053038 DOI: 10.1523/JNEUROSCI.1698-16.2016 |
0.798 |
|
| 2017 |
Selkoe DJ. TREATING ALZHEIMER’S DISEASE BY TARGETING β-AMYLOID: WHERE DO WE STAND? Alzheimer's & Dementia. 13: P545-P546. DOI: 10.1016/j.jalz.2017.07.137 |
0.343 |
|
| 2016 |
Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D. Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9041-56. PMID 27581448 DOI: 10.1523/JNEUROSCI.1023-16.2016 |
0.717 |
|
| 2016 |
Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ. The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase. Elife. 5. PMID 27580372 DOI: 10.7554/eLife.17578 |
0.461 |
|
| 2016 |
Nuber S, Selkoe DJ. Caspase-1 clipping causes complications for α-synuclein. Proceedings of the National Academy of Sciences of the United States of America. PMID 27551083 DOI: 10.1073/pnas.1610993113 |
0.351 |
|
| 2016 |
Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones. Bioorganic & Medicinal Chemistry Letters. PMID 27038496 DOI: 10.1016/j.bmcl.2016.03.077 |
0.306 |
|
| 2016 |
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science (New York, N.Y.). PMID 27033548 DOI: 10.1126/Science.Aad8373 |
0.606 |
|
| 2016 |
Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer's disease at 25 years. Embo Molecular Medicine. PMID 27025652 DOI: 10.15252/Emmm.201606210 |
0.444 |
|
| 2016 |
Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols. Bioorganic & Medicinal Chemistry Letters. PMID 27020305 DOI: 10.1016/j.bmcl.2016.03.042 |
0.316 |
|
| 2016 |
Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE. Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs. Bioorganic & Medicinal Chemistry Letters. PMID 27013392 DOI: 10.1016/j.bmcl.2016.03.040 |
0.371 |
|
| 2016 |
Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nature Reviews. Neuroscience. 17: 251-60. PMID 26988744 DOI: 10.1038/nrn.2016.13 |
0.617 |
|
| 2016 |
Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ. Author response: The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase Elife. DOI: 10.7554/Elife.17578.016 |
0.379 |
|
| 2016 |
Wolfe MS, Bolduc DM, Montagna DR, Seghers M, Selkoe DJ. P4-071: The Amyloid-B Generating Tri-Peptide Cleavage Mechanism of Gamma-Secretase: Implications for Alzheimer's Disease Alzheimer's & Dementia. 12: P1041-P1041. DOI: 10.1016/j.jalz.2016.06.2161 |
0.387 |
|
| 2016 |
Jin M, O'Malley TT, Boyd J, Liu W, Frosch MP, Walsh DM, Selkoe DJ. P4-058: A Novel Paradigm for the Identification and Targeting of Bioactive Abeta Species from Alzheimer Brain Alzheimer's & Dementia. 12: P1037-P1037. DOI: 10.1016/J.Jalz.2016.06.2148 |
0.349 |
|
| 2015 |
Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS. Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699478 DOI: 10.1073/pnas.1512952113 |
0.303 |
|
| 2015 |
Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. The Journal of Cell Biology. 211: 1157-76. PMID 26694839 DOI: 10.1083/Jcb.201502001 |
0.689 |
|
| 2015 |
Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J. A Fluorescent Analog of Batimastat Enables Imaging of α-Secretase in Living Cells. Acs Chemical Neuroscience. PMID 26559179 DOI: 10.1021/Acschemneuro.5B00283 |
0.579 |
|
| 2015 |
Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiology of Disease. 85: 111-121. PMID 26525100 DOI: 10.1016/J.Nbd.2015.10.019 |
0.765 |
|
| 2015 |
Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Cell Reports. PMID 26299970 DOI: 10.1016/J.Celrep.2015.07.061 |
0.693 |
|
| 2015 |
Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, ... Selkoe DJ, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887 |
0.668 |
|
| 2015 |
Dettmer U, Selkoe D, Bartels T. New insights into cellular α-synuclein homeostasis in health and disease. Current Opinion in Neurobiology. 36: 15-22. PMID 26282834 DOI: 10.1016/j.conb.2015.07.007 |
0.811 |
|
| 2015 |
Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10851-65. PMID 26224867 DOI: 10.1523/Jneurosci.0387-15.2015 |
0.763 |
|
| 2015 |
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 8008. PMID 26224447 DOI: 10.1038/ncomms9008 |
0.791 |
|
| 2015 |
Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... Selkoe DJ, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a Journal of Neurology. 138: 2659-71. PMID 26220939 DOI: 10.1093/Brain/Awv202 |
0.709 |
|
| 2015 |
Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D. KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 112: 9596-601. PMID 26153422 DOI: 10.1073/pnas.1505953112 |
0.817 |
|
| 2015 |
Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D. Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation. Nature Communications. 6: 7314. PMID 26076669 DOI: 10.1038/Ncomms8314 |
0.799 |
|
| 2015 |
Jin M, Selkoe DJ. Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol. Neurobiology of Disease. 82: 152-163. PMID 26054438 DOI: 10.1016/j.nbd.2015.05.020 |
0.444 |
|
| 2015 |
Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/S13195-015-0100-Y |
0.59 |
|
| 2015 |
Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ. Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity. Biochemistry. 54: 279-92. PMID 25490121 DOI: 10.1021/bi501188a |
0.786 |
|
| 2014 |
Bartels T, Kim NC, Luth ES, Selkoe DJ. N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation. Plos One. 9: e103727. PMID 25075858 DOI: 10.1371/journal.pone.0103727 |
0.736 |
|
| 2014 |
Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ. Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes. American Journal of Hematology. 89: 974-7. PMID 25043722 DOI: 10.1002/Ajh.23796 |
0.646 |
|
| 2014 |
Wolfe MS, Selkoe DJ. γ-Secretase: a horseshoe structure brings good luck. Cell. 158: 247-9. PMID 25036627 DOI: 10.1016/j.cell.2014.06.043 |
0.312 |
|
| 2014 |
Luth ES, Stavrovskaya IG, Bartels T, Kristal BS, Selkoe DJ. Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction. The Journal of Biological Chemistry. 289: 21490-507. PMID 24942732 DOI: 10.1074/jbc.M113.545749 |
0.709 |
|
| 2014 |
Holmes O, Paturi S, Selkoe DJ, Wolfe MS. Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry. 53: 4393-406. PMID 24941111 DOI: 10.1021/bi500489j |
0.381 |
|
| 2014 |
Holmes O, Paturi S, Wolfe MS, Selkoe DJ. Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies. Journal of Neurochemistry. 131: 94-100. PMID 24865334 DOI: 10.1111/Jnc.12772 |
0.395 |
|
| 2014 |
Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, et al. Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. The Lancet. Neurology. 13: 614-29. PMID 24849862 DOI: 10.1016/S1474-4422(14)70090-0 |
0.368 |
|
| 2014 |
Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 53: 3908-21. PMID 24840308 DOI: 10.1021/Bi5003053 |
0.646 |
|
| 2014 |
Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ. Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes. Neuron. 82: 308-19. PMID 24685176 DOI: 10.1016/J.Neuron.2014.02.027 |
0.785 |
|
| 2014 |
Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Human Molecular Genetics. 23: 3523-36. PMID 24524897 DOI: 10.1093/Hmg/Ddu064 |
0.834 |
|
| 2014 |
Selkoe D, Dettmer U, Luth E, Kim N, Newman A, Bartels T. Defining the native state of α-synuclein Neurodegenerative Diseases. 13: 114-117. PMID 24192542 DOI: 10.1159/000355516 |
0.816 |
|
| 2013 |
Selkoe DJ. The therapeutics of Alzheimer's disease: where we stand and where we are heading. Annals of Neurology. 74: 328-36. PMID 25813842 DOI: 10.1002/ana.24001 |
0.411 |
|
| 2013 |
Newman AJ, Selkoe D, Dettmer U. A new method for quantitative immunoblotting of endogenous α-synuclein. Plos One. 8: e81314. PMID 24278419 DOI: 10.1371/journal.pone.0081314 |
0.797 |
|
| 2013 |
Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, ... ... Selkoe DJ, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635 |
0.372 |
|
| 2013 |
Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, ... ... Selkoe DJ, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 81: 1531-7. PMID 24068787 DOI: 10.1212/Wnl.0B013E3182A95818 |
0.669 |
|
| 2013 |
Selkoe DJ. SnapShot: pathobiology of Alzheimer's disease. Cell. 154: 468-468.e1. PMID 23870132 DOI: 10.1016/j.cell.2013.07.003 |
0.366 |
|
| 2013 |
Rice HC, Young-Pearse TL, Selkoe DJ. Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Biochemistry. 52: 3264-77. PMID 23597280 DOI: 10.1021/Bi400165F |
0.809 |
|
| 2013 |
Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL. Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS. Glia. 61: 985-1002. PMID 23536313 DOI: 10.1002/Glia.22490 |
0.741 |
|
| 2013 |
Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ. Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers. Neuron. 77: 929-41. PMID 23473322 DOI: 10.1016/J.Neuron.2012.12.040 |
0.731 |
|
| 2013 |
Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 99-112. PMID 23375565 DOI: 10.1016/J.Jalz.2012.11.005 |
0.755 |
|
| 2013 |
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells. The Journal of Biological Chemistry. 288: 6371-85. PMID 23319586 DOI: 10.1074/jbc.M112.403311 |
0.806 |
|
| 2013 |
Bartels T, Selkoe DJ. Bartels & Selkoe reply Nature. 498: E6-E7. DOI: 10.1038/nature12126 |
0.318 |
|
| 2013 |
Augelli-Szafran C, Brogan K, Cai C, Chen J, Gu Y, Selkoe D, Wei H, Wolfe M, Zhang J. Gamma-secretase as a target for Alzheimer's disease therapy: Small-molecule development Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1687 |
0.323 |
|
| 2013 |
Muratore C, Rice H, Srikanth P, Selkoe D, Young-Pearse T. O1-01-05: Human iPSC-derived neurons reveal novel effects of the APP London mutation and show cell fate-specific Alzheimer's disease relevant phenotypes Alzheimer's & Dementia. 9: P126-P127. DOI: 10.1016/J.Jalz.2013.04.053 |
0.806 |
|
| 2012 |
Findeis MA, Schroeder F, McKee TD, Yager D, Fraering PC, Creaser SP, Austin WF, Clardy J, Wang R, Selkoe D, Eckman CB. Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. Acs Chemical Neuroscience. 3: 941-51. PMID 23205187 DOI: 10.1021/Cn3000857 |
0.368 |
|
| 2012 |
Holtzman DM, Mandelkow E, Selkoe DJ. Alzheimer disease in 2020. Cold Spring Harbor Perspectives in Medicine. 2. PMID 23125202 DOI: 10.1101/Cshperspect.A011585 |
0.339 |
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| 2012 |
Selkoe DJ. Preventing Alzheimer's disease. Science (New York, N.Y.). 337: 1488-92. PMID 22997326 DOI: 10.1126/science.1228541 |
0.318 |
|
| 2012 |
Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Development (Cambridge, England). 139: 3986-96. PMID 22992957 DOI: 10.1242/Dev.082909 |
0.81 |
|
| 2012 |
Mucke L, Selkoe DJ. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. Cold Spring Harbor Perspectives in Medicine. 2: a006338. PMID 22762015 DOI: 10.1101/cshperspect.a006338 |
0.43 |
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| 2012 |
Masters CL, Selkoe DJ. Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a006262. PMID 22675658 DOI: 10.1101/Cshperspect.A006262 |
0.471 |
|
| 2012 |
Holmes O, Paturi S, Ye W, Wolfe MS, Selkoe DJ. Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry. 51: 3565-75. PMID 22489600 DOI: 10.1021/bi300303g |
0.369 |
|
| 2012 |
Koyama A, Okereke OI, Yang T, Blacker D, Selkoe DJ, Grodstein F. Plasma amyloid-β as a predictor of dementia and cognitive decline: a systematic review and meta-analysis. Archives of Neurology. 69: 824-31. PMID 22451159 DOI: 10.1001/archneurol.2011.1841 |
0.328 |
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| 2012 |
Selkoe D, Mandelkow E, Holtzman D. Deciphering Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2: a011460. PMID 22315723 DOI: 10.1101/Cshperspect.A011460 |
0.35 |
|
| 2012 |
Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, ... ... Selkoe DJ, et al. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. 39: 209-19. PMID 22218879 DOI: 10.1007/S00259-011-2045-0 |
0.481 |
|
| 2012 |
Yakunin E, Loeb V, Kisos H, Biala Y, Yehuda S, Yaari Y, Selkoe DJ, Sharon R. Α-synuclein neuropathology is controlled by nuclear hormone receptors and enhanced by docosahexaenoic acid in a mouse model for Parkinson's disease. Brain Pathology (Zurich, Switzerland). 22: 280-94. PMID 21929559 DOI: 10.1111/j.1750-3639.2011.00530.x |
0.396 |
|
| 2011 |
Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: II. Review of human trials and recommendations. Archives of Neurology. 68: 1385-92. PMID 22084122 DOI: 10.1001/Archneurol.2011.242 |
0.34 |
|
| 2011 |
Wang X, Winter D, Ashrafi G, Schlehe J, Wong YL, Selkoe D, Rice S, Steen J, LaVoie MJ, Schwarz TL. PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell. 147: 893-906. PMID 22078885 DOI: 10.1016/J.Cell.2011.10.018 |
0.622 |
|
| 2011 |
Hong S, Quintero-Monzon O, Ostaszewski BL, Podlisny DR, Cavanaugh WT, Yang T, Holtzman DM, Cirrito JR, Selkoe DJ. Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15861-9. PMID 22049429 DOI: 10.1523/Jneurosci.3272-11.2011 |
0.623 |
|
| 2011 |
Shepardson NE, Shankar GM, Selkoe DJ. Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Archives of Neurology. 68: 1239-44. PMID 21987540 DOI: 10.1001/Archneurol.2011.203 |
0.327 |
|
| 2011 |
Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, ... ... Selkoe DJ, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2283-6. PMID 21953863 DOI: 10.1002/Mds.23934 |
0.701 |
|
| 2011 |
Selkoe DJ. Resolving controversies on the path to Alzheimer's therapeutics. Nature Medicine. 17: 1060-5. PMID 21900936 DOI: 10.1038/nm.2460 |
0.322 |
|
| 2011 |
Bartels T, Choi JG, Selkoe DJ. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature. 477: 107-10. PMID 21841800 DOI: 10.1038/nature10324 |
0.775 |
|
| 2011 |
Selkoe DJ. Alzheimer's disease. Cold Spring Harbor Perspectives in Biology. 3. PMID 21576255 DOI: 10.1101/cshperspect.a004457 |
0.341 |
|
| 2011 |
Li S, Jin M, Koeglsperger T, Shepardson NE, Shankar GM, Selkoe DJ. Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6627-38. PMID 21543591 DOI: 10.1523/Jneurosci.0203-11.2011 |
0.746 |
|
| 2011 |
Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proceedings of the National Academy of Sciences of the United States of America. 108: 5819-24. PMID 21421841 DOI: 10.1073/Pnas.1017033108 |
0.658 |
|
| 2011 |
Davis RC, Marsden IT, Maloney MT, Minamide LS, Podlisny M, Selkoe DJ, Bamburg JR. Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation. Molecular Neurodegeneration. 6: 10. PMID 21261978 DOI: 10.1186/1750-1326-6-10 |
0.331 |
|
| 2011 |
Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid β-protein oligomers from cultured cells, CSF, and brain. Methods in Molecular Biology (Clifton, N.J.). 670: 33-44. PMID 20967581 DOI: 10.1007/978-1-60761-744-0_3 |
0.622 |
|
| 2011 |
Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiology of Aging. 32: 2211-8. PMID 20097446 DOI: 10.1016/J.Neurobiolaging.2010.01.001 |
0.566 |
|
| 2011 |
Koyama A, Okereke O, Yang T, Selkoe D, Grodstein F. Plasma amyloid-beta as a predictor of dementia and cognitive decline: A systematic review and meta-analysis Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.923 |
0.322 |
|
| 2011 |
Rice H, Young-Pearse T, Selkoe D. P2-310: Candidate-based search for Amyloid Precursor Protein ligands that modulate α-secretase cleavage Alzheimer's & Dementia. 7: S409-S410. DOI: 10.1016/J.Jalz.2011.05.1188 |
0.796 |
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| 2010 |
Young-Pearse TL, Suth S, Luth ES, Sawa A, Selkoe DJ. Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10431-40. PMID 20685985 DOI: 10.1523/Jneurosci.1445-10.2010 |
0.695 |
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| 2010 |
Wolfe MS, Selkoe DJ. Giving Alzheimer's the old one-two. Cell. 142: 194-6. PMID 20655461 DOI: 10.1016/j.cell.2010.07.006 |
0.437 |
|
| 2010 |
Li S, Shankar GM, Selkoe DJ. How do Soluble Oligomers of Amyloid beta-protein Impair Hippocampal Synaptic Plasticity? Frontiers in Cellular Neuroscience. 4: 5. PMID 20428510 DOI: 10.3389/Fncel.2010.00005 |
0.32 |
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| 2010 |
Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D, De Strooper B. Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. Journal of Alzheimer's Disease : Jad. 20: 1119-32. PMID 20413872 DOI: 10.3233/JAD-2010-091633 |
0.396 |
|
| 2010 |
Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain : a Journal of Neurology. 133: 1328-41. PMID 20403962 DOI: 10.1093/Brain/Awq065 |
0.652 |
|
| 2010 |
Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. The Febs Journal. 277: 1503-18. PMID 20163459 DOI: 10.1111/j.1742-4658.2010.07579.x |
0.654 |
|
| 2010 |
Chen AC, Guo LY, Ostaszewski BL, Selkoe DJ, LaVoie MJ. Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates. The Journal of Biological Chemistry. 285: 11378-91. PMID 20145246 DOI: 10.1074/Jbc.M109.088815 |
0.778 |
|
| 2010 |
Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Medicine. 12: 27-43. PMID 20069392 DOI: 10.1007/S12017-009-8109-7 |
0.484 |
|
| 2010 |
Shahani N, Young-Pearse T, Selkoe D, Sawa A. P2-247: Role of Disrupted-in-Schizophrenia-1 (DISC1) in amyloid precursor protein (APP) processing and Aβ generation Alzheimer's & Dementia. 6: S386-S387. DOI: 10.1016/J.Jalz.2010.05.1296 |
0.668 |
|
| 2010 |
Bamburg JR, Bernstein BW, Davis RC, Goldsbury C, Maloney MT, Marsden IT, Minamide LS, Pak CW, Perry G, Podlisny MB, Selkoe DJ, Shaw AE, Siedlak SL, Whiteman IT. P2-219: ADF/cofilin-actin rods and synaptic loss in Alzheimer's disease Alzheimer's & Dementia. 6: S378-S378. DOI: 10.1016/J.Jalz.2010.05.1268 |
0.326 |
|
| 2010 |
Maloney M, Wu C, Davis R, Minamide L, Podlisny M, Selkoe D. [P2.49]: Secreted amyloid beta and impaired neurotrophin transport: Potential mediators of abnormal cns development and neurodegeneration in down syndrome International Journal of Developmental Neuroscience. 28: 703-704. DOI: 10.1016/J.Ijdevneu.2010.07.179 |
0.343 |
|
| 2009 |
Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Identification of beta-secretase (BACE1) substrates using quantitative proteomics. Plos One. 4: e8477. PMID 20041192 DOI: 10.1371/Journal.Pone.0008477 |
0.734 |
|
| 2009 |
Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-year change in plasma amyloid beta levels and late-life cognitive decline. Archives of Neurology. 66: 1247-53. PMID 19822780 DOI: 10.1001/archneurol.2009.207 |
0.343 |
|
| 2009 |
Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. Journal of Immunology (Baltimore, Md. : 1950). 183: 3522-30. PMID 19675171 DOI: 10.4049/Jimmunol.0900620 |
0.523 |
|
| 2009 |
Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiology of Disease. 36: 293-302. PMID 19660551 DOI: 10.1016/J.Nbd.2009.07.021 |
0.644 |
|
| 2009 |
Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63: 178-88. PMID 19640477 DOI: 10.1016/J.Neuron.2009.07.003 |
0.531 |
|
| 2009 |
Rappley I, Myers DS, Milne SB, Ivanova PT, Lavoie MJ, Brown HA, Selkoe DJ. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype. Journal of Neurochemistry. 111: 15-25. PMID 19627450 DOI: 10.1111/J.1471-4159.2009.06290.X |
0.786 |
|
| 2009 |
Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 62: 788-801. PMID 19555648 DOI: 10.1016/J.Neuron.2009.05.012 |
0.724 |
|
| 2009 |
Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Research. 1262: 89-99. PMID 19401174 DOI: 10.1016/J.Brainres.2009.01.008 |
0.657 |
|
| 2009 |
Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. Plos One. 4: e5274. PMID 19384407 DOI: 10.1371/Journal.Pone.0005274 |
0.319 |
|
| 2009 |
Li H, Wolfe MS, Selkoe DJ. Toward structural elucidation of the gamma-secretase complex. Structure (London, England : 1993). 17: 326-34. PMID 19278647 DOI: 10.1016/J.Str.2009.01.007 |
0.35 |
|
| 2009 |
Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. Journal of Alzheimer's Disease : Jad. 16: 277-85. PMID 19221417 DOI: 10.3233/Jad-2009-0948 |
0.392 |
|
| 2009 |
Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Archives of Neurology. 66: 190-9. PMID 19204155 DOI: 10.1001/Archneurol.2008.565 |
0.624 |
|
| 2009 |
Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry. 48: 1077-83. PMID 19146388 DOI: 10.1021/Bi801871H |
0.806 |
|
| 2009 |
Osenkowski P, Li H, Ye W, Li D, Aeschbach L, Fraering PC, Wolfe MS, Selkoe DJ, Li H. Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. Journal of Molecular Biology. 385: 642-52. PMID 19013469 DOI: 10.1016/J.Jmb.2008.10.078 |
0.41 |
|
| 2009 |
Ben Gedalya T, Loeb V, Israeli E, Altschuler Y, Selkoe DJ, Sharon R. Alpha-synuclein and polyunsaturated fatty acids promote clathrin-mediated endocytosis and synaptic vesicle recycling. Traffic (Copenhagen, Denmark). 10: 218-34. PMID 18980610 DOI: 10.1111/j.1600-0854.2008.00853.x |
0.316 |
|
| 2008 |
Hemming ML, Elias JE, Gygi SP, Selkoe DJ. Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. Plos Biology. 6: e257. PMID 18942891 DOI: 10.1371/Journal.Pbio.0060257 |
0.73 |
|
| 2008 |
Selkoe DJ. Biochemistry and molecular biology of amyloid beta-protein and the mechanism of Alzheimer's disease. Handbook of Clinical Neurology. 89: 245-60. PMID 18631749 DOI: 10.1016/S0072-9752(07)01223-7 |
0.456 |
|
| 2008 |
Neant-Fery M, Garcia-Ordoñez RD, Logan TP, Selkoe DJ, Li L, Reinstatler L, Leissring MA. Molecular basis for the thiol sensitivity of insulin-degrading enzyme. Proceedings of the National Academy of Sciences of the United States of America. 105: 9582-7. PMID 18621727 DOI: 10.1073/Pnas.0801261105 |
0.341 |
|
| 2008 |
Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiology of Disease. 31: 442-50. PMID 18602473 DOI: 10.1016/J.Nbd.2008.06.001 |
0.629 |
|
| 2008 |
Young-Pearse TL, Chen AC, Chang R, Marquez C, Selkoe DJ. Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1. Neural Development. 3: 15. PMID 18573216 DOI: 10.1186/1749-8104-3-15 |
0.768 |
|
| 2008 |
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nature Medicine. 14: 837-42. PMID 18568035 DOI: 10.1038/Nm1782 |
0.661 |
|
| 2008 |
Osenkowski P, Ye W, Wang R, Wolfe MS, Selkoe DJ. Direct and potent regulation of gamma-secretase by its lipid microenvironment. The Journal of Biological Chemistry. 283: 22529-40. PMID 18539594 DOI: 10.1074/jbc.M801925200 |
0.329 |
|
| 2008 |
Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4231-7. PMID 18417702 DOI: 10.1523/Jneurosci.5161-07.2008 |
0.649 |
|
| 2008 |
Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behavioural Brain Research. 192: 106-13. PMID 18359102 DOI: 10.1016/j.bbr.2008.02.016 |
0.475 |
|
| 2008 |
Nazer B, Hong S, Selkoe DJ. LRP promotes endocytosis and degradation, but not transcytosis, of the amyloid-beta peptide in a blood-brain barrier in vitro model. Neurobiology of Disease. 30: 94-102. PMID 18289866 DOI: 10.1016/J.Nbd.2007.12.005 |
0.639 |
|
| 2008 |
Weihofen A, Ostaszewski B, Minami Y, Selkoe DJ. Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1. Human Molecular Genetics. 17: 602-16. PMID 18003639 DOI: 10.1093/hmg/ddm334 |
0.361 |
|
| 2008 |
Cacquevel M, Aeschbach L, Osenkowski P, Li D, Ye W, Wolfe MS, Li H, Selkoe DJ, Fraering PC. Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. Journal of Neurochemistry. 104: 210-20. PMID 17986218 DOI: 10.1111/J.1471-4159.2007.05041.X |
0.42 |
|
| 2008 |
Shimura H, Schlossmacher M, Hattori N, Mizuno Y, Kosik K, Selkoe D. Interaction between parkin and alpha-synuclein Journal of Neurochemistry. 81: 3-3. DOI: 10.1046/J.1471-4159.81.S1.49_4.X |
0.557 |
|
| 2008 |
Xia W, Yang T, Smith IM, Walsh DM, Selkoe DJ. P1-368: Monomeric and oligmeric Aβ assays on plasma of Alzheimer patients Alzheimer's & Dementia. 4: T327-T327. DOI: 10.1016/j.jalz.2008.05.950 |
0.569 |
|
| 2008 |
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. O2-02-02: Soluble amyloid β-protein dimers isolated directly from Alzheimer's disease patients potently impair synaptic plasticity and memory Alzheimer's & Dementia. 4: T133-T133. DOI: 10.1016/J.Jalz.2008.05.314 |
0.374 |
|
| 2008 |
McDonald JM, Brayne C, Savva G, Mattews FE, Welzel A, Shankar GM, Ince PG, Selkoe DJ, Walsh DM. P3-415: The presence of Abeta dimers in soluble brain extract is associated with dementia Alzheimer's & Dementia. 4: T643-T643. DOI: 10.1016/J.Jalz.2008.05.1986 |
0.581 |
|
| 2008 |
Farris W, Peng Y, Lemere CA, Selkoe DJ, Kovács K. P3-326: Neprilysin regulates the anatomical distribution of amyloid pathology in an age-dependent manner Alzheimer's & Dementia. 4: T617-T617. DOI: 10.1016/j.jalz.2008.05.1895 |
0.318 |
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| 2007 |
Selkoe DJ. Developing preventive therapies for chronic diseases: lessons learned from Alzheimer's disease. Nutrition Reviews. 65: S239-43. PMID 18240556 DOI: 10.1111/j.1753-4887.2007.tb00370.x |
0.47 |
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| 2007 |
Young-Pearse TL, Bai J, Chang R, Zheng JB, LoTurco JJ, Selkoe DJ. A critical function for beta-amyloid precursor protein in neuronal migration revealed by in utero RNA interference. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 14459-69. PMID 18160654 DOI: 10.1523/Jneurosci.4701-07.2007 |
0.719 |
|
| 2007 |
Assayag K, Yakunin E, Loeb V, Selkoe DJ, Sharon R. Polyunsaturated fatty acids induce alpha-synuclein-related pathogenic changes in neuronal cells. The American Journal of Pathology. 171: 2000-11. PMID 18055555 DOI: 10.2353/ajpath.2007.070373 |
0.348 |
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| 2007 |
Selkoe DJ, Wolfe MS. Presenilin: running with scissors in the membrane. Cell. 131: 215-21. PMID 17956719 DOI: 10.1016/j.cell.2007.10.012 |
0.353 |
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| 2007 |
Townsend M, Mehta T, Selkoe DJ. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. The Journal of Biological Chemistry. 282: 33305-12. PMID 17855343 DOI: 10.1074/jbc.M610390200 |
0.401 |
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| 2007 |
Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ. Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease. Plos Medicine. 4: e262. PMID 17760499 DOI: 10.1371/Journal.Pmed.0040262 |
0.755 |
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| 2007 |
Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. The American Journal of Pathology. 171: 241-51. PMID 17591969 DOI: 10.2353/Ajpath.2007.070105 |
0.652 |
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| 2007 |
Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochemical Society Transactions. 35: 416-20. PMID 17371289 DOI: 10.1042/Bst0350416 |
0.655 |
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| 2007 |
Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2866-75. PMID 17360908 DOI: 10.1523/Jneurosci.4970-06.2007 |
0.64 |
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| 2007 |
Hemming ML, Selkoe DJ, Farris W. Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease. Neurobiology of Disease. 26: 273-81. PMID 17321748 DOI: 10.1016/J.Nbd.2007.01.004 |
0.747 |
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| 2007 |
Chen AC, Selkoe DJ. Response to: Pardossi-Piquard et al., "Presenilin-Dependent Transcriptional Control of the Abeta-Degrading Enzyme Neprilysin by Intracellular Domains of betaAPP and APLP." Neuron 46, 541-554. Neuron. 53: 479-83. PMID 17296549 DOI: 10.1016/j.neuron.2007.01.023 |
0.505 |
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| 2007 |
Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. Journal of Neurochemistry. 101: 1172-84. PMID 17286590 DOI: 10.1111/j.1471-4159.2006.04426.x |
0.637 |
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| 2007 |
Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews. Molecular Cell Biology. 8: 101-12. PMID 17245412 DOI: 10.1038/Nrm2101 |
0.699 |
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| 2007 |
Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/Jbc.M609168200 |
0.359 |
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| 2007 |
Qiu WQ, Sun X, Selkoe DJ, Mwamburi DM, Huang T, Bhadela R, Bergethon P, Scott TM, Summergrad P, Wang L, Rosenberg I, Folstein M. Depression is associated with low plasma Abeta42 independently of cardiovascular disease in the homebound elderly. International Journal of Geriatric Psychiatry. 22: 536-42. PMID 17096467 DOI: 10.1002/Gps.1710 |
0.309 |
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| 2007 |
Sperling R, LaViolette P, White E, Becker JA, Moran E, Gregas M, Klunk W, Mathis C, Price J, Fischman A, Selkoe D, Rentz D, Johnson K. O1-05-01: Cortical amyloid deposition related to failure of hippocampal activation Alzheimers & Dementia. 3. DOI: 10.1016/J.Jalz.2007.04.068 |
0.459 |
|
| 2006 |
Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Annals of Neurology. 60: 668-76. PMID 17192927 DOI: 10.1002/Ana.21051 |
0.627 |
|
| 2006 |
Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10222-31. PMID 17021177 DOI: 10.1523/Jneurosci.2250-06.2006 |
0.467 |
|
| 2006 |
Selkoe DJ. Amyloid beta-peptide is produced by cultured cells during normal metabolism: a reprise. Journal of Alzheimer's Disease : Jad. 9: 163-8. PMID 16914855 DOI: 10.3233/Jad-2006-9S319 |
0.459 |
|
| 2006 |
Selkoe DJ. The ups and downs of Abeta. Nature Medicine. 12: 758-9; discussion 75. PMID 16829932 DOI: 10.1038/nm0706-758 |
0.347 |
|
| 2006 |
Lazarov VK, Fraering PC, Ye W, Wolfe MS, Selkoe DJ, Li H. Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proceedings of the National Academy of Sciences of the United States of America. 103: 6889-94. PMID 16636269 DOI: 10.1073/Pnas.0602321103 |
0.392 |
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| 2006 |
Réchards M, Xia W, Oorschot V, van Dijk S, Annaert W, Selkoe DJ, Klumperman J. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments. Traffic (Copenhagen, Denmark). 7: 354-64. PMID 16497228 DOI: 10.1111/j.1600-0854.2006.00388.x |
0.436 |
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| 2006 |
Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. The Journal of Physiology. 572: 477-92. PMID 16469784 DOI: 10.1113/Jphysiol.2005.103754 |
0.637 |
|
| 2006 |
Selkoe DJ. The aging mind: Deciphering Alzheimer's disease & its antecedents Daedalus. 135: 58-67. DOI: 10.1162/001152606775321112 |
0.343 |
|
| 2006 |
Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. DT-02-03: TARGET ENGAGEMENT IN AN AD TRIAL: CRENEZUMAB LOWERS Aβ OLIGOMER LEVELS IN CSF Alzheimer's & Dementia. 14: P1669-P1670. DOI: 10.1016/j.jalz.2018.07.012 |
0.323 |
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| 2006 |
Walsh DM, Jin M, Wang Z, Liu W, Lagomarsino V, Weeden T, Reczek D, Young-Pearse T, Pradier L, Selkoe DJ. P1-106: A HEAD-TO-HEAD COMPARISON OF LEAD CLINICAL ANTI-Aβ ANTIBODIES Alzheimer's & Dementia. 14: P312-P312. DOI: 10.1016/J.Jalz.2018.06.109 |
0.707 |
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| 2006 |
Betts V, Leissring MA, Selkoe DJ, Walsh DM. P1-391: Monomeric Aβ peptides bearing the Flemish A21G mutation are less readily degraded by neprilysin than wild type Aβ Alzheimer's & Dementia. 2: S212-S213. DOI: 10.1016/J.Jalz.2006.05.769 |
0.58 |
|
| 2006 |
Farris W, Schütz SG, Sun X, Qiu WQ, Selkoe DJ. O4-06-06: Endogenous neprilysin modulates cerebral Aβ levels, amyloid plaque burden, and amyloid angiopathy in human APP transgenic mice Alzheimer's & Dementia. 2: S88-S89. DOI: 10.1016/j.jalz.2006.05.341 |
0.389 |
|
| 2006 |
Young-Pearse TL, Bai J, Zheng J, LoTurco J, Selkoe DJ. O4-05-08: In utero gene transfer reveals a function for APP in cortical cell migration Alzheimer's & Dementia. 2: S86-S87. DOI: 10.1016/J.Jalz.2006.05.334 |
0.613 |
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| 2006 |
Townsend M, Selkoe DJ. O4-02-04: Opposing roles of APP and Abeta on synaptic plasticity Alzheimer's & Dementia. 2: S77-S78. DOI: 10.1016/j.jalz.2006.05.303 |
0.302 |
|
| 2006 |
Sperling R, Depeau K, Miller S, Chua E, Rentz D, Dickerson B, Atri A, Selkoe D, Johnson K, Calhoun V, Albert M, Celone K. Ic-101-05 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2344 |
0.355 |
|
| 2006 |
Johnson KA, Pollen D, Rentz D, Moran E, Becker JA, Moonis M, Swearer J, Hyman B, Selkoe D, Sperling R, DeKosky S, Matthis C, Klunk W, Fischman A. IC-103-03: Amyloid deposition in presymptomatic familial Alzheimer's disease Alzheimer's & Dementia. 2: S653-S653. DOI: 10.1016/J.Jalz.2006.05.2198 |
0.511 |
|
| 2006 |
Minogue AM, Fadeeva JV, Tang J, Wasco W, Selkoe DJ, Walsh DM. P3-352: APLP1-derived peptides do not undergo rapid fibrillogenesis Alzheimer's & Dementia. 2: S478-S478. DOI: 10.1016/J.Jalz.2006.05.1622 |
0.504 |
|
| 2006 |
Sperling R, Depeau K, Miller S, Chua E, Dorene R, Dickerson B, Atri A, Selkoe D, Albert M, Calhoun V, Celone K. P2-302: FMRI alterations medial temporal and neocortical networks in MCI and AD Alzheimer's & Dementia. 2: S328-S329. DOI: 10.1016/J.Jalz.2006.05.1142 |
0.431 |
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| 2006 |
Johnson KA, Pollen D, Rentz D, Moran E, Becker JA, Moonis M, Swearer J, Hyman B, Selkoe D, Sperling R, DeKosky S, Matthis C, Klunk W, Fischman A. P2-268: Amyloid deposition in presymptomatic familial Alzheimer's disease Alzheimer's & Dementia. 2: S317-S317. DOI: 10.1016/J.Jalz.2006.05.1107 |
0.525 |
|
| 2006 |
Selkoe D, Townsend M, Shankar G, Mehta T, Podlisny M, Walsh D. S1-02-04: Role of AB oligomers in AD Alzheimer's & Dementia. 2: S4-S4. DOI: 10.1016/J.Jalz.2006.05.016 |
0.577 |
|
| 2005 |
Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochemical Society Transactions. 33: 1087-90. PMID 16246051 DOI: 10.1042/Bst20051087 |
0.651 |
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| 2005 |
Whalen BM, Selkoe DJ, Hartley DM. Small non-fibrillar assemblies of amyloid beta-protein bearing the Arctic mutation induce rapid neuritic degeneration. Neurobiology of Disease. 20: 254-66. PMID 16242634 DOI: 10.1016/J.Nbd.2005.03.007 |
0.825 |
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| 2005 |
Fraering PC, Ye W, LaVoie MJ, Ostaszewski BL, Selkoe DJ, Wolfe MS. gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. The Journal of Biological Chemistry. 280: 41987-96. PMID 16236717 DOI: 10.1074/Jbc.M501368200 |
0.691 |
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| 2005 |
LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ. Dopamine covalently modifies and functionally inactivates parkin. Nature Medicine. 11: 1214-21. PMID 16227987 DOI: 10.1038/Nm1314 |
0.674 |
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| 2005 |
Hemming ML, Selkoe DJ. Amyloid beta-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor. The Journal of Biological Chemistry. 280: 37644-50. PMID 16154999 DOI: 10.1074/Jbc.M508460200 |
0.741 |
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| 2005 |
Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5533-43. PMID 15944381 DOI: 10.1523/Jneurosci.4883-04.2005 |
0.664 |
|
| 2005 |
Farris W, Leissring MA, Hemming ML, Chang AY, Selkoe DJ. Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein. Biochemistry. 44: 6513-25. PMID 15850385 DOI: 10.1021/Bi0476578 |
0.738 |
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| 2005 |
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nature Medicine. 11: 556-61. PMID 15834427 DOI: 10.1038/Nm1234 |
0.634 |
|
| 2005 |
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2455-62. PMID 15758153 DOI: 10.1523/Jneurosci.4391-04.2005 |
0.647 |
|
| 2005 |
Selkoe DJ. Defining molecular targets to prevent Alzheimer disease. Archives of Neurology. 62: 192-5. PMID 15710846 DOI: 10.1001/archneur.62.2.192 |
0.369 |
|
| 2005 |
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nature Neuroscience. 8: 79-84. PMID 15608634 DOI: 10.1038/Nn1372 |
0.611 |
|
| 2005 |
Chyung JH, Raper DM, Selkoe DJ. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. The Journal of Biological Chemistry. 280: 4383-92. PMID 15569674 DOI: 10.1074/Jbc.M409272200 |
0.809 |
|
| 2004 |
Selkoe DJ. Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nature Cell Biology. 6: 1054-61. PMID 15516999 DOI: 10.1038/ncb1104-1054 |
0.415 |
|
| 2004 |
Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 44: 181-93. PMID 15450169 DOI: 10.1016/j.neuron.2004.09.010 |
0.589 |
|
| 2004 |
Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neuroscience Letters. 366: 320-5. PMID 15288443 DOI: 10.1016/j.neulet.2004.05.060 |
0.62 |
|
| 2004 |
Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. The Biochemical Journal. 383: 439-46. PMID 15285718 DOI: 10.1042/Bj20041081 |
0.327 |
|
| 2004 |
Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS. Purification and characterization of the human gamma-secretase complex. Biochemistry. 43: 9774-89. PMID 15274632 DOI: 10.1021/Bi0494976 |
0.709 |
|
| 2004 |
Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, Selkoe DJ, Palmour RM, Ervin FR. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. The American Journal of Pathology. 165: 283-97. PMID 15215183 DOI: 10.1016/S0002-9440(10)63296-8 |
0.421 |
|
| 2004 |
Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein and Peptide Letters. 11: 213-28. PMID 15182223 DOI: 10.2174/0929866043407174 |
0.675 |
|
| 2004 |
Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K. A seed for Alzheimer amyloid in the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4894-902. PMID 15152051 DOI: 10.1523/JNEUROSCI.0861-04.2004 |
0.469 |
|
| 2004 |
Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. The European Journal of Neuroscience. 19: 2839-46. PMID 15147317 DOI: 10.1111/j.1460-9568.2004.03389.x |
0.6 |
|
| 2004 |
Selkoe DJ. Alzheimer disease: mechanistic understanding predicts novel therapies. Annals of Internal Medicine. 140: 627-38. PMID 15096334 DOI: 10.7326/0003-4819-140-8-200404200-00047 |
0.329 |
|
| 2004 |
Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3370-8. PMID 15056716 DOI: 10.1523/JNEUROSCI.1633-03.2004 |
0.583 |
|
| 2004 |
Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. The American Journal of Pathology. 164: 1425-34. PMID 15039230 DOI: 10.1016/S0002-9440(10)63229-4 |
0.45 |
|
| 2004 |
Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS. Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry. 43: 323-33. PMID 14717586 DOI: 10.1021/Bi035748J |
0.77 |
|
| 2004 |
Klyubin I, Walsh DM, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. P2-004 Anti-Aβ antibodies prevention block of long-term potentiation in the CA1 area of rat hippocampus in vivo by naturally produced Aβ oligomers Neurobiology of Aging. 25: S224-S225. DOI: 10.1016/S0197-4580(04)80752-8 |
0.557 |
|
| 2004 |
Walsh DM, Kylubin I, Cleary JP, Townsend TM, Shankar GM, Podlisny MB, Fadeeva JV, Anwyl R, Ashe KH, Rowan MJ, Selkoe DJ. P1-230 Natural, cell-derived Aβ oligomers: their production, biological activity and inhibition Neurobiology of Aging. 25: S161-S162. DOI: 10.1016/S0197-4580(04)80543-8 |
0.565 |
|
| 2004 |
Fadeeva JV, Walsh DM, Tang J, Luo Y, Citron M, Wasco W, Selkoe DJ. P1-218 Generation of the intracellular C-terminal domain of the APP family of proteins does not require β-secretase Neurobiology of Aging. 25: S158. DOI: 10.1016/S0197-4580(04)80531-1 |
0.553 |
|
| 2004 |
Townsend M, Podlisny M, Shankar G, Fadeeva J, Walsh D, Selkoe D. O4-03-04 Reversal of AB induced LTP deficits by compounds that inhibit AB oligomerization Neurobiology of Aging. 25: S78-S79. DOI: 10.1016/S0197-4580(04)80267-7 |
0.5 |
|
| 2004 |
Selkoe DJ, LaVoie M, Fraering P, Ostaszewski B, Ye W, Zheng B, Taylor Kimberly W, Wolfe M. S2-03-01 Presenilin as the active site of gamma-secretase, a novel intramembranous aspartyl protease Neurobiology of Aging. 25: S28. DOI: 10.1016/S0197-4580(04)80091-5 |
0.638 |
|
| 2003 |
Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 40: 1087-93. PMID 14687544 DOI: 10.1016/S0896-6273(03)00787-6 |
0.667 |
|
| 2003 |
Selkoe DJ. Folding proteins in fatal ways. Nature. 426: 900-4. PMID 14685251 DOI: 10.1038/nature02264 |
0.423 |
|
| 2003 |
Selkoe DJ. Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman. Neurochemical Research. 28: 1705-13. PMID 14584824 DOI: 10.1023/A:1026065122854 |
0.418 |
|
| 2003 |
Baulac S, LaVoie MJ, Kimberly WT, Strahle J, Wolfe MS, Selkoe DJ, Xia W. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiology of Disease. 14: 194-204. PMID 14572442 DOI: 10.1016/S0969-9961(03)00123-2 |
0.78 |
|
| 2003 |
Chyung JH, Selkoe DJ. Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. The Journal of Biological Chemistry. 278: 51035-43. PMID 14525989 DOI: 10.1074/Jbc.M304989200 |
0.814 |
|
| 2003 |
Sharon R, Bar-Joseph I, Mirick GE, Serhan CN, Selkoe DJ. Altered fatty acid composition of dopaminergic neurons expressing alpha-synuclein and human brains with alpha-synucleinopathies. The Journal of Biological Chemistry. 278: 49874-81. PMID 14507911 DOI: 10.1074/Jbc.M309127200 |
0.344 |
|
| 2003 |
Lemere CA, Spooner ET, LaFrancois J, Malester B, Mori C, Leverone JF, Matsuoka Y, Taylor JW, DeMattos RB, Holtzman DM, Clements JD, Selkoe DJ, Duff KE. Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice. Neurobiology of Disease. 14: 10-8. PMID 13678662 DOI: 10.1016/S0969-9961(03)00044-5 |
0.367 |
|
| 2003 |
Ye CP, Selkoe DJ, Hartley DM. Protofibrils of amyloid beta-protein inhibit specific K+ currents in neocortical cultures. Neurobiology of Disease. 13: 177-90. PMID 12901832 DOI: 10.1016/S0969-9961(03)00068-8 |
0.397 |
|
| 2003 |
Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of Clinical Investigation. 112: 415-22. PMID 12897209 DOI: 10.1172/Jci18104 |
0.634 |
|
| 2003 |
Leissring MA, Lu A, Condron MM, Teplow DB, Stein RL, Farris W, Selkoe DJ. Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays. The Journal of Biological Chemistry. 278: 37314-20. PMID 12867419 DOI: 10.1074/Jbc.M305627200 |
0.417 |
|
| 2003 |
LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. The Journal of Biological Chemistry. 278: 37213-22. PMID 12857757 DOI: 10.1074/Jbc.M303941200 |
0.77 |
|
| 2003 |
LaVoie MJ, Selkoe DJ. The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. The Journal of Biological Chemistry. 278: 34427-37. PMID 12826675 DOI: 10.1074/Jbc.M302659200 |
0.653 |
|
| 2003 |
Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 42: 6664-73. PMID 12779321 DOI: 10.1021/Bi027375C |
0.824 |
|
| 2003 |
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proceedings of the National Academy of Sciences of the United States of America. 100: 6382-7. PMID 12740439 DOI: 10.1073/Pnas.1037392100 |
0.789 |
|
| 2003 |
Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annual Review of Neuroscience. 26: 565-97. PMID 12730322 DOI: 10.1146/annurev.neuro.26.041002.131334 |
0.418 |
|
| 2003 |
Farris W, Mansourian S, Chang Y, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S. Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 4162-7. PMID 12634421 DOI: 10.1073/Pnas.0230450100 |
0.436 |
|
| 2003 |
Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 37: 583-95. PMID 12597857 DOI: 10.1016/S0896-6273(03)00024-2 |
0.596 |
|
| 2003 |
Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 42: 137-44. PMID 12515548 DOI: 10.1021/bi026888g |
0.663 |
|
| 2003 |
Selkoe DJ, Schenk D. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annual Review of Pharmacology and Toxicology. 43: 545-84. PMID 12415125 DOI: 10.1146/annurev.pharmtox.43.100901.140248 |
0.46 |
|
| 2003 |
Walsh D, Hartley D, Selkoe D. The Many Faces of Aβ: Structures and Activity Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3: 277-291. DOI: 10.2174/1568013033483311 |
0.484 |
|
| 2002 |
Weiner HL, Selkoe DJ. Inflammation and therapeutic vaccination in CNS diseases. Nature. 420: 879-84. PMID 12490962 DOI: 10.1038/Nature01325 |
0.449 |
|
| 2002 |
Selkoe DJ. Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease. The Journal of Clinical Investigation. 110: 1375-81. PMID 12438432 DOI: 10.1172/JCI16783 |
0.483 |
|
| 2002 |
Selkoe DJ. Alzheimer's disease is a synaptic failure. Science (New York, N.Y.). 298: 789-91. PMID 12399581 DOI: 10.1126/science.1074069 |
0.404 |
|
| 2002 |
Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochemical Society Transactions. 30: 552-7. PMID 12196135 DOI: 10.1042/BST0300552 |
0.633 |
|
| 2002 |
Selkoe DJ, Podlisny MB. Deciphering the genetic basis of Alzheimer's disease. Annual Review of Genomics and Human Genetics. 3: 67-99. PMID 12142353 DOI: 10.1146/annurev.genom.3.022502.103022 |
0.468 |
|
| 2002 |
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (New York, N.Y.). 297: 353-6. PMID 12130773 DOI: 10.1126/Science.1072994 |
0.473 |
|
| 2002 |
Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. The Journal of Biological Chemistry. 277: 35113-7. PMID 12130643 DOI: 10.1074/Jbc.M204446200 |
0.765 |
|
| 2002 |
Wolfe MS, Selkoe DJ. Biochemistry. Intramembrane proteases--mixing oil and water. Science (New York, N.Y.). 296: 2156-7. PMID 12077393 DOI: 10.1126/science.1073844 |
0.389 |
|
| 2002 |
Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. The American Journal of Pathology. 160: 1655-67. PMID 12000718 DOI: 10.1016/S0002-9440(10)61113-3 |
0.65 |
|
| 2002 |
Esler WP, Das C, Campbell WA, Kimberly WT, Kornilova AY, Diehl TS, Ye W, Ostaszewski BL, Xia W, Selkoe DJ, Wolfe MS. Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nature Cell Biology. 4: E110-1; author reply. PMID 11988746 DOI: 10.1038/ncb0502-e110b |
0.645 |
|
| 2002 |
Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 416: 535-9. PMID 11932745 DOI: 10.1038/416535a |
0.655 |
|
| 2002 |
Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proceedings of the National Academy of Sciences of the United States of America. 99: 2720-5. PMID 11867728 DOI: 10.1073/pnas.052436599 |
0.672 |
|
| 2002 |
Zhang J, Ye W, Wang R, Wolfe MS, Greenberg BD, Selkoe DJ. Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. The Journal of Biological Chemistry. 277: 15069-75. PMID 11839734 DOI: 10.1074/jbc.M105375200 |
0.301 |
|
| 2002 |
Selkoe DJ. Introducing transglutaminase into the study of Alzheimer's disease. A personal look back. Neurochemistry International. 40: 13-6. PMID 11738468 DOI: 10.1016/S0197-0186(01)00057-2 |
0.339 |
|
| 2002 |
Mori C, Spooner ET, Wisniewski KE, Wisniewski TM, Yamaguchi H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA. Intraneuronal Aβ42 accumulation in Down syndrome brain Amyloid. 9: 88-102. DOI: 10.3109/13506120208995241 |
0.45 |
|
| 2002 |
Walsh DM, Kylubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Cell-derived Aβ oligomers: production, activity and inhibition Biochemical Society Transactions. 30: A56-A56. DOI: 10.1042/bst030a056 |
0.573 |
|
| 2001 |
Selkoe DJ. Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. Journal of Alzheimer's Disease : Jad. 3: 75-80. PMID 12214075 DOI: 10.3233/Jad-2001-3111 |
0.453 |
|
| 2001 |
Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. Dna and Cell Biology. 20: 705-11. PMID 11788048 DOI: 10.1089/10445490152717569 |
0.533 |
|
| 2001 |
Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron. 32: 177-80. PMID 11683988 DOI: 10.1016/S0896-6273(01)00475-5 |
0.455 |
|
| 2001 |
Selkoe DJ. Presenilin, Notch, and the genesis and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 11039-41. PMID 11572965 DOI: 10.1073/pnas.211352598 |
0.471 |
|
| 2001 |
Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. The Journal of Biological Chemistry. 276: 40288-92. PMID 11544248 DOI: 10.1074/jbc.C100447200 |
0.666 |
|
| 2001 |
Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 10273-8. PMID 11517335 DOI: 10.1073/Pnas.191118298 |
0.556 |
|
| 2001 |
Sharon R, Goldberg MS, Bar-Josef I, Betensky RA, Shen J, Selkoe DJ. alpha-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 9110-5. PMID 11481478 DOI: 10.1073/Pnas.171300598 |
0.334 |
|
| 2001 |
Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science (New York, N.Y.). 293: 263-9. PMID 11431533 DOI: 10.1126/Science.1060627 |
0.552 |
|
| 2001 |
Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. The Biochemical Journal. 355: 869-77. PMID 11311152 DOI: 10.1042/Bj3550869 |
0.651 |
|
| 2001 |
Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiological Reviews. 81: 741-66. PMID 11274343 DOI: 10.1152/Physrev.2001.81.2.741 |
0.466 |
|
| 2001 |
Selkoe DJ. Presenilins, β-amyloid precursor protein and the molecular basis of Alzheimer's disease Clinical Neuroscience Research. 1: 91-103. DOI: 10.1016/S1566-2772(00)00016-5 |
0.474 |
|
| 2000 |
Selkoe DJ. Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein. Annals of the New York Academy of Sciences. 924: 17-25. PMID 11193794 DOI: 10.1111/J.1749-6632.2000.Tb05554.X |
0.454 |
|
| 2000 |
Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Annals of the New York Academy of Sciences. 920: 328-31. PMID 11193172 DOI: 10.1111/J.1749-6632.2000.Tb06943.X |
0.494 |
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| 2000 |
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 223-6. PMID 11193154 DOI: 10.1111/J.1749-6632.2000.Tb06926.X |
0.378 |
|
| 2000 |
Moore CL, Diehl TS, Selkoe DJ, Wolfe MS. Toward the characterization and identification of gamma-secretases using transition-state analogue inhibitors. Annals of the New York Academy of Sciences. 920: 197-205. PMID 11193150 DOI: 10.1111/j.1749-6632.2000.tb06922.x |
0.381 |
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| 2000 |
Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis MG, Go RC, Vekrellis K, Selkoe DJ, Saunders AJ, Tanzi RE. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science (New York, N.Y.). 290: 2302-3. PMID 11125142 DOI: 10.1126/Science.290.5500.2302 |
0.372 |
|
| 2000 |
Xia W, Ostaszewski BL, Kimberly WT, Rahmati T, Moore CL, Wolfe MS, Selkoe DJ. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex. Neurobiology of Disease. 7: 673-81. PMID 11114265 DOI: 10.1006/nbdi.2000.0322 |
0.667 |
|
| 2000 |
Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nature Structural Biology. 7: 1095-9. PMID 11101888 DOI: 10.1038/81937 |
0.583 |
|
| 2000 |
Selkoe DJ. The genetics and molecular pathology of Alzheimer's disease: roles of amyloid and the presenilins. Neurologic Clinics. 18: 903-22. PMID 11072267 DOI: 10.1016/S0733-8619(05)70232-2 |
0.385 |
|
| 2000 |
Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Annals of Neurology. 48: 567-79. PMID 11026440 |
0.321 |
|
| 2000 |
Chesneau V, Vekrellis K, Rosner MR, Selkoe DJ. Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization. The Biochemical Journal. 351: 509-16. PMID 11023838 DOI: 10.1042/Bj3510509 |
0.425 |
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| 2000 |
Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 7: 166-78. PMID 11019857 DOI: 10.3109/13506120009146831 |
0.578 |
|
| 2000 |
Moore CL, Leatherwood DD, Diehl TS, Selkoe DJ, Wolfe MS. Difluoro ketone peptidomimetics suggest a large S1 pocket for Alzheimer's gamma-secretase: implications for inhibitor design. Journal of Medicinal Chemistry. 43: 3434-42. PMID 10978191 DOI: 10.1021/jm000100f |
0.418 |
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| 2000 |
Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 39: 10831-9. PMID 10978169 DOI: 10.1021/bi001048s |
0.639 |
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| 2000 |
Selkoe DJ. Imaging Alzheimer's amyloid. Nature Biotechnology. 18: 823-4. PMID 10932146 DOI: 10.1038/78422 |
0.363 |
|
| 2000 |
Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proceedings of the National Academy of Sciences of the United States of America. 97: 9299-304. PMID 10922078 DOI: 10.1073/Pnas.97.16.9299 |
0.675 |
|
| 2000 |
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. Journal of Neurochemistry. 75: 583-93. PMID 10899933 DOI: 10.1046/J.1471-4159.2000.0750583.X |
0.676 |
|
| 2000 |
Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nature Cell Biology. 2: 428-34. PMID 10878808 DOI: 10.1038/35017062 |
0.685 |
|
| 2000 |
Selkoe DJ, Wolfe MS. In search of gamma-secretase: presenilin at the cutting edge. Proceedings of the National Academy of Sciences of the United States of America. 97: 5690-2. PMID 10823929 DOI: 10.1073/PNAS.97.11.5690 |
0.448 |
|
| 2000 |
Selkoe DJ. The origins of Alzheimer disease: a is for amyloid. Jama. 283: 1615-7. PMID 10735401 DOI: 10.1001/Jama.283.12.1615 |
0.43 |
|
| 2000 |
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 1657-65. PMID 10684867 |
0.352 |
|
| 2000 |
Selkoe DJ. Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration. Current Opinion in Neurobiology. 10: 50-7. PMID 10679435 DOI: 10.1016/S0959-4388(99)00054-9 |
0.341 |
|
| 2000 |
Stoltzner SE, Grenfell TJ, Mori C, Wisniewski KE, Wisniewski TM, Selkoe DJ, Lemere CA. Temporal accrual of complement proteins in amyloid plaques in Down's syndrome with Alzheimer's disease. The American Journal of Pathology. 156: 489-99. PMID 10666378 DOI: 10.1016/S0002-9440(10)64753-0 |
0.432 |
|
| 2000 |
Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. The Journal of Biological Chemistry. 275: 3173-8. PMID 10652302 DOI: 10.1074/jbc.275.5.3173 |
0.688 |
|
| 2000 |
Vekrellis K, Ye Z, Qiu WQ, Walsh D, Hartley D, Chesneau V, Rosner MR, Selkoe DJ. Neurons Regulate Extracellular Levels of Amyloid β-Protein via Proteolysis by Insulin-Degrading Enzyme The Journal of Neuroscience. 20: 1657-1665. DOI: 10.1523/Jneurosci.20-05-01657.2000 |
0.645 |
|
| 2000 |
CHESNEAU V, VEKRELLIS K, ROSNER MR, SELKOE DJ. Purified recombinant insulin-degrading enzyme degrades amyloid β-protein but does not promote its oligomerization Biochemical Journal. 351: 509-516. DOI: 10.1042/BJ3510509 |
0.304 |
|
| 2000 |
Esler WP, Diehl TS, Ostaszewski BL, Moore CL, Xia W, Kimberly WT, Selkoe DJ, Wolfe MS. Toward identification of gamma-secretase using transition-state analogue inhibitors Neurobiology of Aging. 21: 278. DOI: 10.1016/S0197-4580(00)83201-7 |
0.564 |
|
| 2000 |
Monsonego A, Maron R, Bar-Or A, Krieger JI, Selkoe D, Weiner HL. The role of T cell reactivity to A-beta amyloid peptide in the pathogenic processes associated with Alzheimer's disease Neurobiology of Aging. 21: 23. DOI: 10.1016/S0197-4580(00)82780-3 |
0.533 |
|
| 2000 |
Berezovska O, Jack CE, Aster JC, Wolfe MS, Selkoe DJ, Hyman BT. γ-Secretase inhibitors which have been shown to block Aβ production do not abolish Notch1 signaling Neurobiology of Aging. 21: 78. DOI: 10.1016/S0197-4580(00)82576-2 |
0.309 |
|
| 2000 |
Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhut JJ, Teplow DB. A de novo designed α-helical peptide forms amyloid fibrils which are not neurotoxic Neurobiology of Aging. 21: 77. DOI: 10.1016/S0197-4580(00)82568-3 |
0.574 |
|
| 2000 |
Selkoe DJ, Xia W, Taylor Kimberly W, Vekrellis K, Walsh D, Wolfe MS. Molecular basis of presenilin's role in APP processing Neurobiology of Aging. 21: 70. DOI: 10.1016/S0197-4580(00)82534-8 |
0.555 |
|
| 2000 |
Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Selkoe DJ. Nasal Aβ immunization reduces amyloid-β protein burden in PDAPP mice Neurobiology of Aging. 21: 126. DOI: 10.1016/S0197-4580(00)82364-7 |
0.357 |
|
| 2000 |
Mori C, Wisniewski K, Wisniewski T, Saido TC, Selkoe DJ, Lemere CA. Intraneuronal Aβ42 immunoreactivity is inversely correlated with Alzheimer's disease pathology in down syndrome brain: A temporal study Neurobiology of Aging. 21: 121. DOI: 10.1016/S0197-4580(00)82344-1 |
0.39 |
|
| 2000 |
Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease Annals of Neurology. 48: 567-579. DOI: 10.1002/1531-8249(200010)48:4<567::Aid-Ana3>3.0.Co;2-W |
0.549 |
|
| 1999 |
Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. The Journal of Biological Chemistry. 274: 36801-7. PMID 10593990 DOI: 10.1074/Jbc.274.51.36801 |
0.378 |
|
| 1999 |
Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8876-84. PMID 10516307 DOI: 10.1523/Jneurosci.19-20-08876.1999 |
0.49 |
|
| 1999 |
Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry. 38: 11223-30. PMID 10471271 DOI: 10.1021/Bi991080Q |
0.46 |
|
| 1999 |
Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. The Journal of Biological Chemistry. 274: 25945-52. PMID 10464339 DOI: 10.1074/Jbc.274.36.25945 |
0.656 |
|
| 1999 |
Poduslo JF, Curran GL, Sanyal B, Selkoe DJ. Receptor-mediated transport of human amyloid beta-protein 1-40 and 1-42 at the blood-brain barrier. Neurobiology of Disease. 6: 190-9. PMID 10408808 DOI: 10.1006/nbdi.1999.0238 |
0.399 |
|
| 1999 |
Lemere CA, Grenfell TJ, Selkoe DJ. The AMY antigen co-occurs with abeta and follows its deposition in the amyloid plaques of Alzheimer's disease and down syndrome. The American Journal of Pathology. 155: 29-37. PMID 10393833 DOI: 10.1016/S0002-9440(10)65095-X |
0.423 |
|
| 1999 |
Selkoe DJ. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature. 399: A23-31. PMID 10392577 DOI: 10.1038/399A023 |
0.451 |
|
| 1999 |
Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. The Journal of Biological Chemistry. 274: 18851-6. PMID 10383380 DOI: 10.1074/Jbc.274.27.18851 |
0.785 |
|
| 1999 |
Watson DJ, Selkoe DJ, Teplow DB. Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein. The Biochemical Journal. 340: 703-9. PMID 10359654 DOI: 10.1042/Bj3400703 |
0.429 |
|
| 1999 |
Querfurth HW, Jiang J, Xia W, Selkoe DJ. Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter. Gene. 232: 125-41. PMID 10333529 DOI: 10.1016/S0378-1119(99)00091-8 |
0.342 |
|
| 1999 |
Westermark P, Araki S, Benson MD, Cohen AS, Frangione B, Masters CL, Saraiva MJ, Sipe JD, Husby G, Kyle RA, Selkoe D. Nomenclature of amyloid fibril proteins. Report from the meeting of the International Nomenclature Committee on Amyloidosis, August 8-9, 1998. Part 1. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 6: 63-6. PMID 10211413 DOI: 10.3109/13506129908993290 |
0.383 |
|
| 1999 |
Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 398: 513-7. PMID 10206644 DOI: 10.1038/19077 |
0.702 |
|
| 1999 |
Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry. 38: 4720-7. PMID 10200159 DOI: 10.1021/bi982562p |
0.443 |
|
| 1999 |
Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons The Journal of Neuroscience. 19: 8876-8884. DOI: 10.1523/JNEUROSCI.19-20-08876.1999 |
0.55 |
|
| 1998 |
Selkoe DJ. The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. Trends in Cell Biology. 8: 447-53. PMID 9854312 DOI: 10.1016/S0962-8924(98)01363-4 |
0.456 |
|
| 1998 |
Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 37: 16465-71. PMID 9843412 DOI: 10.1021/Bi9816195 |
0.769 |
|
| 1998 |
Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry. 273: 32730-8. PMID 9830016 DOI: 10.1074/Jbc.273.49.32730 |
0.64 |
|
| 1998 |
Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. The Journal of Biological Chemistry. 273: 32322-31. PMID 9822712 DOI: 10.1074/Jbc.273.48.32322 |
0.674 |
|
| 1998 |
Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiology of Disease. 5: 107-16. PMID 9746908 DOI: 10.1006/Nbdi.1998.0183 |
0.399 |
|
| 1998 |
Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. Journal of the Neurological Sciences. 158: 15-23. PMID 9667772 DOI: 10.1016/S0022-510X(98)00106-3 |
0.452 |
|
| 1998 |
Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. The Journal of Biological Chemistry. 273: 12436-42. PMID 9575200 DOI: 10.1074/Jbc.273.20.12436 |
0.709 |
|
| 1998 |
Davies P, Resnick J, Resnick B, Gilman S, Growdon JH, Khachaturian ZS, Radebaugh TS, Roses AD, Selkoe DJ, Trojanowski JQ, Blass JP, Gibson GE, Sheu KFR, Blennow K, Delacourte A, et al. Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' Neurobiology of Aging. 19: 109-116. PMID 9558143 DOI: 10.1016/S0197-4580(98)00022-0 |
0.568 |
|
| 1998 |
Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry. 37: 3602-11. PMID 9521679 DOI: 10.1021/Bi972029U |
0.41 |
|
| 1998 |
Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432 DOI: 10.1074/Jbc.273.6.3205 |
0.618 |
|
| 1998 |
Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 391: 339-40. PMID 9450743 DOI: 10.1038/34800 |
0.684 |
|
| 1997 |
Watson DJ, Lander AD, Selkoe DJ. Heparin-binding properties of the amyloidogenic peptides Abeta and amylin. Dependence on aggregation state and inhibition by Congo red. The Journal of Biological Chemistry. 272: 31617-24. PMID 9395501 DOI: 10.1074/Jbc.272.50.31617 |
0.406 |
|
| 1997 |
Querfurth HW, Jiang J, Geiger JD, Selkoe DJ. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. Journal of Neurochemistry. 69: 1580-91. PMID 9326287 DOI: 10.1046/j.1471-4159.1997.69041580.x |
0.377 |
|
| 1997 |
Poduslo JF, Curran GL, Haggard JJ, Biere AL, Selkoe DJ. Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1-40 at the blood-brain barrier. Neurobiology of Disease. 4: 27-34. PMID 9258909 DOI: 10.1006/nbdi.1997.0132 |
0.367 |
|
| 1997 |
Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 8208-13. PMID 9223340 DOI: 10.1073/Pnas.94.15.8208 |
0.635 |
|
| 1997 |
Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/Nbdi.1997.0129 |
0.746 |
|
| 1997 |
Shen J, Bronson RT, Chen DF, Xia W, Selkoe DJ, Tonegawa S. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89: 629-39. PMID 9160754 DOI: 10.1016/S0092-8674(00)80244-5 |
0.359 |
|
| 1997 |
Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 94: 5349-54. PMID 9144240 DOI: 10.1073/Pnas.94.10.5349 |
0.62 |
|
| 1997 |
Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/Jbc.272.12.7977 |
0.757 |
|
| 1997 |
Qiu WQ, Ye Z, Kholodenko D, Seubert P, Selkoe DJ. Degradation of amyloid beta-protein by a metalloprotease secreted by microglia and other neural and non-neural cells. The Journal of Biological Chemistry. 272: 6641-6. PMID 9045694 DOI: 10.1074/jbc.272.10.6641 |
0.452 |
|
| 1997 |
Selkoe DJ. Alzheimer's disease: genotypes, phenotypes, and treatments. Science (New York, N.Y.). 275: 630-1. PMID 9019820 DOI: 10.1126/SCIENCE.275.5300.630 |
0.4 |
|
| 1997 |
Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878 DOI: 10.1074/Jbc.272.3.1896 |
0.627 |
|
| 1997 |
Yamazaki T, Koo EH, Selkoe DJ. Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1004-10. PMID 8994055 DOI: 10.1523/Jneurosci.17-03-01004.1997 |
0.581 |
|
| 1997 |
Citron M, Westaway D, Xia W, Carlson G, Diehl T, Levesque G, Johnson-Wood K, Lee M, Seubert P, Davis A, Kholodenko D, Motter R, Sherrington R, Perry B, Yao H, ... ... Selkoe DJ, et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice. Nature Medicine. 3: 67-72. PMID 8986743 DOI: 10.1038/Nm0197-67 |
0.432 |
|
| 1997 |
Yamazaki T, Koo EH, Selkoe DJ. Cell Surface Amyloid β-Protein Precursor Colocalizes with β1 Integrins at Substrate Contact Sites in Neural Cells The Journal of Neuroscience. 17: 1004-1010. DOI: 10.1523/JNEUROSCI.17-03-01004.1997 |
0.5 |
|
| 1996 |
Selkoe DJ. Cell biology of the beta-amyloid precursor protein and the genetics of Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 587-96. PMID 9246485 DOI: 10.1101/Sqb.1996.061.01.059 |
0.444 |
|
| 1996 |
Stephenson DT, Lemere CA, Selkoe DJ, Clemens JA. Cytosolic phospholipase A2 (cPLA2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiology of Disease. 3: 51-63. PMID 9173912 DOI: 10.1006/nbdi.1996.0005 |
0.395 |
|
| 1996 |
Lemere CA, Blusztajn JK, Yamaguchi H, Wisniewski T, Saido TC, Selkoe DJ. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiology of Disease. 3: 16-32. PMID 9173910 DOI: 10.1006/Nbdi.1996.0003 |
0.393 |
|
| 1996 |
Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483 DOI: 10.1007/Bf03401652 |
0.682 |
|
| 1996 |
Lalowski M, Golabek A, Lemere CA, Selkoe DJ, Wisniewski HM, Beavis RC, Frangione B, Wisniewski T. The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid. The Journal of Biological Chemistry. 271: 33623-31. PMID 8969231 DOI: 10.1074/Jbc.271.52.33623 |
0.412 |
|
| 1996 |
Biere AL, Ostaszewski B, Stimson ER, Hyman BT, Maggio JE, Selkoe DJ. Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma. The Journal of Biological Chemistry. 271: 32916-22. PMID 8955133 DOI: 10.1074/Jbc.271.51.32916 |
0.413 |
|
| 1996 |
Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9 |
0.365 |
|
| 1996 |
Citron M, Diehl TS, Gordon G, Biere AL, Seubert P, Selkoe DJ. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proceedings of the National Academy of Sciences of the United States of America. 93: 13170-5. PMID 8917563 DOI: 10.1073/pnas.93.23.13170 |
0.395 |
|
| 1996 |
Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, ... Selkoe DJ, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/Nm1096-1146 |
0.701 |
|
| 1996 |
Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiology of Aging. 17: 653-9. PMID 8832640 DOI: 10.1016/0197-4580(96)00062-0 |
0.357 |
|
| 1996 |
Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American Journal of Pathology. 149: 1063-71. PMID 8780408 |
0.316 |
|
| 1996 |
Selkoe DJ. Amyloid beta-protein and the genetics of Alzheimer's disease. The Journal of Biological Chemistry. 271: 18295-8. PMID 8756120 DOI: 10.1074/jbc.271.31.18295 |
0.435 |
|
| 1996 |
Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 17: 171-9. PMID 8755488 DOI: 10.1016/S0896-6273(00)80290-1 |
0.64 |
|
| 1996 |
Yamazaki T, Koo EH, Selkoe DJ. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. Journal of Cell Science. 109: 999-1008. PMID 8743947 |
0.531 |
|
| 1996 |
Koo EH, Squazzo SL, Selkoe DJ, Koo CH. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. Journal of Cell Science. 109: 991-8. PMID 8743946 |
0.581 |
|
| 1996 |
Tamaoka A, Endoh R, Shoji S, Takahashi H, Hirokawa K, Teplow DB, Selkoe DJ, Mori H. Antibodies to amyloid beta protein (A beta) crossreact with glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Neurobiology of Aging. 17: 405-14. PMID 8725902 DOI: 10.1016/0197-4580(96)00031-0 |
0.424 |
|
| 1996 |
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, ... ... Selkoe D, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2: 864-70. PMID 8705854 DOI: 10.1038/Nm0896-864 |
0.414 |
|
| 1996 |
Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. The Journal of Biological Chemistry. 271: 8443-51. PMID 8626544 DOI: 10.1074/Jbc.271.14.8443 |
0.691 |
|
| 1996 |
Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127 DOI: 10.1111/J.1749-6632.1996.Tb34401.X |
0.723 |
|
| 1996 |
Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C. Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation Amyloid. 3: 150-155. DOI: 10.3109/13506129609045514 |
0.643 |
|
| 1996 |
Qiu W, Ye Z, Selkoe D. 697 Degradation of amyloid β-protein by a secreted metallo-protease in neural and non-neural cells Neurobiology of Aging. 17: S173. DOI: 10.1016/S0197-4580(96)80699-3 |
0.34 |
|
| 1996 |
Walters J, Hung A, Thinakaran G, Sisodia S, Selkoe D, Haassl C. 388 Phosphorylation of ß-amyloid precursor protein at two distinct cellular locations Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80390-3 |
0.398 |
|
| 1996 |
Citron M, Xia W, Diehl T, Podlisny M, Sherrington R, Haass C, Seubert P, Hyslop P, Selkoe D. 320 Effect of presenilin mutations on BAPP processing in presenilin transfected cells Neurobiology of Aging. 17: S81. DOI: 10.1016/S0197-4580(96)80322-8 |
0.577 |
|
| 1996 |
Haass C, Walter J, Grünberg J, George-Hyslop PS, Selkoe D, Pesold B, Capell A. 150 Expression of the Presenilin proteins PS-1 and PS-2 in tissue culture cells Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80152-7 |
0.585 |
|
| 1996 |
Younkin S, Scheuner D, Song X, Eckman C, Citron M, Suzuki N, Bird T, Hardy J, Hutton M, Lannfelt L, Levy-Lahad E, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, ... ... Selkoe D, et al. 149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80151-5 |
0.444 |
|
| 1996 |
Selkoe DJ. 146 Amyloidosis of Aβ42 as the common pathogenetic mechanism of all forms of Alzheimer's Disease Neurobiology of Aging. 17: S37. DOI: 10.1016/S0197-4580(96)80148-5 |
0.412 |
|
| 1996 |
Lemere CA, Lopera F, Kosikl KS, Ossa J, Saido TC, Ruiz A, Martinez A, Madrigol L, Hincapie L, Selkoe DJ. 68 Immunocytochemical characterization of plaques, tangles and vascular amyloid in the brains of 2 FAD patients with an identified psi mutation Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80070-4 |
0.36 |
|
| 1996 |
Younkin SG, Song XH, Scheuner D, Eckman C, Prada C, Jensen J, Lannfelt L, Hardy J, Tanzi R, Schellenberg G, Selkoe D, Suzuki N. The effect of amyloid precursor protein and presenilin mutations on amyloid beta protein Biological Psychiatry. 39: 562. DOI: 10.1016/0006-3223(96)84161-8 |
0.428 |
|
| 1995 |
Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiology of Disease. 2: 177-87. PMID 9174001 DOI: 10.1006/Nbdi.1995.0019 |
0.462 |
|
| 1995 |
Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the beta-amyloid precursor protein activates mitogen-activated protein kinase. Neuroscience Letters. 198: 52-6. PMID 8570096 DOI: 10.1016/0304-3940(95)11944-R |
0.562 |
|
| 1995 |
Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2157-67. PMID 7891158 DOI: 10.1523/Jneurosci.15-03-02157.1995 |
0.602 |
|
| 1995 |
Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 6186-92. PMID 7890753 DOI: 10.1074/Jbc.270.11.6186 |
0.638 |
|
| 1995 |
Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/Jcb.128.4.537 |
0.724 |
|
| 1995 |
Querfurth HW, Wijsman EM, St George-Hyslop PH, Selkoe DJ. Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Research. Molecular Brain Research. 28: 319-37. PMID 7723630 DOI: 10.1016/0169-328X(94)00224-3 |
0.367 |
|
| 1995 |
Yamazaki T, Selkoe DJ, Koo EH. Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. The Journal of Cell Biology. 129: 431-42. PMID 7721945 DOI: 10.1083/Jcb.129.2.431 |
0.59 |
|
| 1995 |
Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. The Journal of Biological Chemistry. 270: 9564-70. PMID 7721886 DOI: 10.1074/Jbc.270.16.9564 |
0.597 |
|
| 1995 |
Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American Journal of Pathology. 146: 848-60. PMID 7717452 |
0.637 |
|
| 1995 |
Citron M, Teplow DB, Selkoe DJ. Generation of amyloid beta protein from its precursor is sequence specific. Neuron. 14: 661-70. PMID 7695913 DOI: 10.1016/0896-6273(95)90323-2 |
0.399 |
|
| 1995 |
Selkoe DJ. Alzheimer's disease. Missense on the membrane. Nature. 375: 734-5. PMID 7596402 DOI: 10.1038/375734a0 |
0.351 |
|
| 1995 |
Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical Journal. 311: 299-305. PMID 7575468 DOI: 10.1042/Bj3110299 |
0.658 |
|
| 1995 |
Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Medicine. 1: 1291-6. PMID 7489411 DOI: 10.1038/Nm1295-1291 |
0.634 |
|
| 1995 |
Selkoe DJ. Alzheimer's amyloid of another flavour. Nature Medicine. 1: 998-9. PMID 7489384 DOI: 10.1038/Nm1095-998 |
0.443 |
|
| 1994 |
Hung AY, Selkoe DJ. Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein. The Embo Journal. 13: 534-42. PMID 8313898 DOI: 10.1002/J.1460-2075.1994.Tb06291.X |
0.387 |
|
| 1994 |
Selkoe DJ. Normal and abnormal biology of the beta-amyloid precursor protein. Annual Review of Neuroscience. 17: 489-517. PMID 8210185 DOI: 10.1146/annurev.ne.17.030194.002421 |
0.447 |
|
| 1994 |
Querfurth HW, Selkoe DJ. Calcium ionophore increases amyloid beta peptide production by cultured cells. Biochemistry. 33: 4550-61. PMID 8161510 DOI: 10.1021/Bi00181A016 |
0.369 |
|
| 1994 |
Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445 DOI: 10.1073/Pnas.91.4.1564 |
0.728 |
|
| 1994 |
Selkoe DJ. Alzheimer's disease: a central role for amyloid. Journal of Neuropathology and Experimental Neurology. 53: 438-47. PMID 8083687 DOI: 10.1097/00005072-199409000-00003 |
0.42 |
|
| 1994 |
Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 7104-8. PMID 8041753 DOI: 10.1073/Pnas.91.15.7104 |
0.619 |
|
| 1994 |
Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 17741-8. PMID 8021287 |
0.626 |
|
| 1994 |
Citron M, Vigo-Pelfrey C, Teplow DB, Miller C, Schenk D, Johnston J, Winblad B, Venizelos N, Lannfelt L, Selkoe DJ. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation. Proceedings of the National Academy of Sciences of the United States of America. 91: 11993-7. PMID 7991571 DOI: 10.1073/Pnas.91.25.11993 |
0.402 |
|
| 1994 |
Maness LM, Banks WA, Podlisny MB, Selkoe DJ, Kastin AJ. Passage of human amyloid beta-protein 1-40 across the murine blood-brain barrier. Life Sciences. 55: 1643-50. PMID 7968239 DOI: 10.1016/0024-3205(94)00331-9 |
0.379 |
|
| 1994 |
Selkoe DJ. Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease. Annual Review of Cell Biology. 10: 373-403. PMID 7888181 DOI: 10.1146/annurev.cb.10.110194.002105 |
0.444 |
|
| 1994 |
Selkoe DJ. Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease. Current Opinion in Neurobiology. 4: 708-16. PMID 7849528 DOI: 10.1016/0959-4388(94)90014-0 |
0.475 |
|
| 1994 |
Bons N, Mestre N, Ritchie K, Petter A, Podlisny M, Selkoe D. Identification of amyloid beta protein in the brain of the small, short-lived Lemurian primate Microcebus murinus Neurobiology of Aging. 15: 215-220. PMID 7838294 DOI: 10.1016/0197-4580(94)90115-5 |
0.456 |
|
| 1994 |
Selkoe DJ. Alzheimer's disease beyond 1994: the path to therapeutics. Neurobiology of Aging. 15: S131-3. PMID 7700437 DOI: 10.1016/0197-4580(94)90190-2 |
0.361 |
|
| 1994 |
Johnston J, Cowburn R, Wiehager B, Norgren S, Lannfelt L, Vigo-Pelfrey C, Schenk D, Citron M, Selkoe D, O'Neill C. Amyloid precursor protein expression and β-amyloid release in fibroblast cell lines obtained from family members with the Swedish APP670/671 mutation Neurobiology of Aging. 15: S71. DOI: 10.1016/0197-4580(94)92743-X |
0.383 |
|
| 1994 |
Selkoe DJ. Cellular production of amyloid beta-protein: a direct route to the mechanism and treatment of Alzheimer's disease Journal of the Neurological Sciences. 127: 3. DOI: 10.1016/0022-510X(94)90111-2 |
0.437 |
|
| 1993 |
Koo EH, Park L, Selkoe DJ. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 90: 4748-52. PMID 8506329 DOI: 10.1073/Pnas.90.10.4748 |
0.624 |
|
| 1993 |
Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. The Journal of Biological Chemistry. 268: 3021-4. PMID 8428976 |
0.596 |
|
| 1993 |
Hanley MR, Selkoe DJ. Alzheimer's disease. Amyloid precursor on the G(o) Nature. 362: 14-5. PMID 8383293 DOI: 10.1038/362014A0 |
0.37 |
|
| 1993 |
Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiology of Aging. 14: 571-3. PMID 8295660 DOI: 10.1016/0197-4580(93)90041-9 |
0.64 |
|
| 1993 |
Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 75: 1039-42. PMID 8261505 DOI: 10.1016/0092-8674(93)90312-E |
0.684 |
|
| 1993 |
Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Annals of the New York Academy of Sciences. 695: 109-16. PMID 8239267 DOI: 10.1111/J.1749-6632.1993.Tb23037.X |
0.642 |
|
| 1993 |
Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807 |
0.627 |
|
| 1993 |
Selkoe DJ. Physiological production of the beta-amyloid protein and the mechanism of Alzheimer's disease. Trends in Neurosciences. 16: 403-9. PMID 7504355 DOI: 10.1016/0166-2236(93)90008-A |
0.454 |
|
| 1992 |
Selkoe DJ. Amyloid protein and Alzheimer's disease. Scientific American. 265: 68-71, 74-6, 78. PMID 1785042 DOI: 10.1038/SCIENTIFICAMERICAN1191-68 |
0.446 |
|
| 1992 |
Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (New York, N.Y.). 255: 728-30. PMID 1738847 DOI: 10.1126/Science.1738847 |
0.389 |
|
| 1992 |
Yamaguchi H, Yamazaki T, Lemere CA, Frosch MP, Selkoe DJ. Beta amyloid is focally deposited within the outer basement membrane in the amyloid angiopathy of Alzheimer's disease. An immunoelectron microscopic study. The American Journal of Pathology. 141: 249-59. PMID 1632466 |
0.337 |
|
| 1992 |
Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiology of Aging. 13: 421-34. PMID 1625772 DOI: 10.1016/0197-4580(92)90117-G |
0.652 |
|
| 1992 |
Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500A0 |
0.733 |
|
| 1992 |
Joachim CL, Selkoe DJ. The seminal role of beta-amyloid in the pathogenesis of Alzheimer disease. Alzheimer Disease and Associated Disorders. 6: 7-34. PMID 1605946 DOI: 10.1097/00002093-199205000-00003 |
0.423 |
|
| 1992 |
Tamaoka A, Kalaria RN, Lieberburg I, Selkoe DJ. Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels. Proceedings of the National Academy of Sciences of the United States of America. 89: 1345-9. PMID 1531538 DOI: 10.1073/Pnas.89.4.1345 |
0.414 |
|
| 1992 |
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360: 672-4. PMID 1465129 DOI: 10.1038/360672A0 |
0.666 |
|
| 1992 |
Fraser PE, Nguyen JT, Inouye H, Surewicz WK, Selkoe DJ, Podlisny MB, Kirschner DA. Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein. Biochemistry. 31: 10716-23. PMID 1420187 DOI: 10.1021/Bi00159A011 |
0.391 |
|
| 1992 |
Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654 DOI: 10.1073/Pnas.89.20.9439 |
0.738 |
|
| 1992 |
Podlisny MB, Stephenson DT, Frosch MP, Lieberburg I, Clemens JA, Selkoe DJ. Synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex. Neurobiology of Aging. 13: 561-7. PMID 1281288 DOI: 10.1016/0197-4580(92)90056-4 |
0.368 |
|
| 1991 |
Podlisny MB, Tolan DR, Selkoe DJ. Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease American Journal of Pathology. 138: 1423-1435. PMID 1905108 |
0.329 |
|
| 1991 |
Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3783-93. PMID 1744690 DOI: 10.1523/Jneurosci.11-12-03783.1991 |
0.65 |
|
| 1991 |
Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron. 6: 487-98. PMID 1673054 DOI: 10.1016/0896-6273(91)90052-2 |
0.379 |
|
| 1991 |
Haass C, Hung A, Selkoe D. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion The Journal of Neuroscience. 11: 3783-3793. DOI: 10.1523/JNEUROSCI.11-12-03783.1991 |
0.611 |
|
| 1990 |
Podlisny MB, Mammen AL, Schlossmacher MG, Palmert MR, Younkin SG, Selkoe DJ. Detection of soluble forms of the beta-amyloid precursor protein in human plasma. Biochemical and Biophysical Research Communications. 167: 1094-101. PMID 2138892 DOI: 10.1016/0006-291X(90)90635-Z |
0.455 |
|
| 1990 |
Bodmer S, Podlisny MB, Selkoe DJ, Heid I, Fontana A. Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease. Biochemical and Biophysical Research Communications. 171: 890-7. PMID 2119582 DOI: 10.1016/0006-291X(90)91229-L |
0.354 |
|
| 1990 |
Selkoe DJ. Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues. Science (New York, N.Y.). 248: 1058-60. PMID 2111582 DOI: 10.1126/SCIENCE.2111582 |
0.437 |
|
| 1990 |
Schlossmacher M, Podlisny M, Mammen A, Barbour R, Palmert M, Younkin S, Schenk D, Selkoe D. CHARACTERIZATION OF SOLUBLE TRUNCATED FORMS OF THE AMYLOID PRECURSOR PROTEIN FROM HUMAN PLASMA Journal of Neuropathology and Experimental Neurology. 49: 310. DOI: 10.1097/00005072-199005000-00154 |
0.373 |
|
| 1990 |
Podlisny M, Ostaszewski B, Tolan D, Selkoe D. COMPLETE HOMOLOGY OF AMYLOID PRECURSOR PROTEIN (APP) IN MONKEY AND HUMAN SUPPORTS A PRIMATE MODEL OF β-AMYLOIDOSIS Journal of Neuropathology and Experimental Neurology. 49: 308. DOI: 10.1097/00005072-199005000-00149 |
0.368 |
|
| 1990 |
Morris J, Joachim C, Selkoe D. PERICAPILLARY AMYLOID IN ALZHEIMERʼS DISEASE (AD) Journal of Neuropathology and Experimental Neurology. 49: 268. DOI: 10.1097/00005072-199005000-00029 |
0.403 |
|
| 1990 |
Joachim C, Mori H, Podlisny M, Platt D, Selkoe D. DIFFERENT IMMUNOREACTTVITIES OF SYNTHETIC AND “NATIVE” β-AMYLOID PROTEIN (βAP) ANTISERA Journal of Neuropathology and Experimental Neurology. 49: 266. DOI: 10.1097/00005072-199005000-00022 |
0.355 |
|
| 1989 |
Whitson JS, Selkoe DJ, Cotman CW. Amyloid β protein enhances the survival of hippocampal neurons in vitro Science. 243: 1488-1490. PMID 2928783 DOI: 10.1126/SCIENCE.2928783 |
0.426 |
|
| 1989 |
Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. Journal of Neuroimmunology. 24: 173-182. PMID 2808689 DOI: 10.1016/0165-5728(89)90115-X |
0.402 |
|
| 1989 |
Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC. Alpha 1-antichymotrypsin is present together with the beta-protein in monkey brain amyloid deposits. Neuroscience. 32: 715-20. PMID 2689908 DOI: 10.1016/0306-4522(89)90292-3 |
0.792 |
|
| 1989 |
Joachim CL, Selkoe DJ. Amyloid protein in Alzheimer's disease. Journal of Gerontology. 44: B77-82. PMID 2661641 DOI: 10.1093/GERONJ/44.4.B77 |
0.462 |
|
| 1989 |
Selkoe DJ. Aging, amyloid, and Alzheimer's disease. The New England Journal of Medicine. 320: 1484-7. PMID 2654637 DOI: 10.1056/NEJM198906013202209 |
0.365 |
|
| 1989 |
Selkoe DJ. Biochemistry of altered brain proteins in Alzheimer's disease. Annual Review of Neuroscience. 12: 463-90. PMID 2648956 DOI: 10.1146/ANNUREV.NE.12.030189.002335 |
0.423 |
|
| 1989 |
Joachim CL, Mori H, Selkoe DJ. Amyloid beta-protein deposition in tissues other than brain in Alzheimer's disease. Nature. 341: 226-30. PMID 2528696 DOI: 10.1038/341226A0 |
0.478 |
|
| 1989 |
Selkoe DJ. Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease. Neurobiology of Aging. 10: 387-95. PMID 2510035 DOI: 10.1016/0197-4580(89)90072-9 |
0.47 |
|
| 1989 |
Selkoe DJ. Amyloid beta protein precursor and the pathogenesis of Alzheimer's disease. Cell. 58: 611-2. PMID 2504495 DOI: 10.1016/0092-8674(89)90093-7 |
0.459 |
|
| 1989 |
Selkoe DJ. The deposition of amyloid proteins in the aging mammalian brain: implications for Alzheimer's disease. Annals of Medicine. 21: 73-6. PMID 2504258 DOI: 10.3109/07853898909149187 |
0.511 |
|
| 1989 |
Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proceedings of the National Academy of Sciences of the United States of America. 86: 6338-42. PMID 2503832 DOI: 10.1073/Pnas.86.16.6338 |
0.419 |
|
| 1989 |
Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG. Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochemical and Biophysical Research Communications. 165: 182-8. PMID 2480122 DOI: 10.1016/0006-291X(89)91052-8 |
0.326 |
|
| 1989 |
Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. THE β AMYLOID PROTEIN PRECURSOR OF ALZHEIMERʼS DISEASE HAS SOLUBLE DERIVATIVES FOUND IN HUMAN BRAIN AND CEREBROSPINAL FLUID Journal of Neuropathology and Experimental Neurology. 48: 378. DOI: 10.1097/00005072-198905000-00237 |
0.39 |
|
| 1989 |
Selkoe D, Mammen A, Podlisny M, Palmert M, Younkin S, Schenk D. DETECTION OF CIRCULATING FORMS OF THE β-AMYLOID PRECURSOR PROTEIN (BAPP) IN HUMAN PLASMA Journal of Neuropathology and Experimental Neurology. 48: 377. DOI: 10.1097/00005072-198905000-00236 |
0.344 |
|
| 1989 |
Podlisny M, Gronbeck A, Tolan D, Olteradorf T, Selkoe D. STUDIES OF THE PROCESSING OF β-AMYLOID PRECURSOR PROTEIN (βAPP) IN HUMAN, MONKEY AND RODENT BRAIN AND IN cDNA-TRANSFECTED CELLS Journal of Neuropathology and Experimental Neurology. 48: 353. DOI: 10.1097/00005072-198905000-00162 |
0.378 |
|
| 1989 |
Games D, Joachim C, Ward P, Henriksson T, Platt D, Schenk D, Selkoe. D. ANTIBODIES TO DISTINCT REGIONS OF β-AMYLOID PRECURSOR PROTEIN (βAPP) DIFFERENTIALLY LABEL ALZHEIMER DISEASE (AD) SENILE PLAQUES Journal of Neuropathology and Experimental Neurology. 48: 330. DOI: 10.1097/00005072-198905000-00094 |
0.305 |
|
| 1988 |
Joachim CL, Morris JH, Selkoe DJ. Clinically diagnosed Alzheimer's disease: autopsy results in 150 cases. Annals of Neurology. 24: 50-6. PMID 3415200 DOI: 10.1002/ana.410240110 |
0.391 |
|
| 1988 |
Abraham CR, Selkoe DJ, Potter H. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Cell. 52: 487-501. PMID 3257719 DOI: 10.1016/0092-8674(88)90462-X |
0.772 |
|
| 1988 |
Joachim CL, Duffy LK, Morris JH, Selkoe DJ. Protein chemical and immunocytochemical studies of meningovascular beta-amyloid protein in Alzheimer's disease and normal aging. Brain Research. 474: 100-11. PMID 3214703 DOI: 10.1016/0006-8993(88)90673-7 |
0.461 |
|
| 1988 |
Cork LC, Powers RE, Selkoe DJ, Davies P, Geyer JJ, Price DL. Neurofibrillary tangles and senile plaques in aged bears. Journal of Neuropathology and Experimental Neurology. 47: 629-41. PMID 3171607 DOI: 10.1097/00005072-198811000-00006 |
0.355 |
|
| 1988 |
Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques. Biochemical and Biophysical Research Communications. 156: 432-7. PMID 3140814 DOI: 10.1016/S0006-291X(88)80859-3 |
0.433 |
|
| 1988 |
Selkoe DJ, Podlisny MB, Joachim CL, Vickers EA, Lee G, Fritz LC, Oltersdorf T. Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues. Proceedings of the National Academy of Sciences of the United States of America. 85: 7341-5. PMID 3140239 DOI: 10.1073/PNAS.85.19.7341 |
0.438 |
|
| 1988 |
Nukina N, Kosik KS, Selkoe DJ. The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain. Neuroscience Letters. 87: 240-6. PMID 3132653 DOI: 10.1016/0304-3940(88)90455-7 |
0.693 |
|
| 1988 |
Duffy LK, Berman‐Podlisny M, Rasool CG, Walsh RL, Selkoe DJ. Studies on the Relationship between Plasma Proteins and Amyloid Fibrils Found in Alzheimer's Disease Annals of the New York Academy of Sciences. 529: 233-235. DOI: 10.1111/J.1749-6632.1988.Tb51468.X |
0.414 |
|
| 1988 |
ABRAHAM CR, SELKOE DJ, POTTER H. ??1-ANTICHYMOTRYPSIN IN BRAIN AGING AND DISEASE Alzheimer Disease & Associated Disorders. 2: 259. DOI: 10.1097/00002093-198802030-00108 |
0.727 |
|
| 1988 |
Selkoe DJ, Podlisny MB, Vickers E, Reynolds A, Fritz L, Oltersdorf T. Detection And Characterization Of The ??-Amyloid Precursor Protein In Neural And Non-Neural Tissues And Cultured Cells Alzheimer Disease & Associated Disorders. 2: 255. DOI: 10.1097/00002093-198802030-00104 |
0.321 |
|
| 1987 |
Selkoe DJ, Bell DS, Podlisny MB, Price DL, Cork LC. Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science (New York, N.Y.). 235: 873-7. PMID 3544219 DOI: 10.1126/Science.3544219 |
0.464 |
|
| 1987 |
Kirschner DA, Inouye H, Duffy LK, Sinclair A, Lind M, Selkoe DJ. Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro. Proceedings of the National Academy of Sciences of the United States of America. 84: 6953-7. PMID 3477820 DOI: 10.1073/Pnas.84.19.6953 |
0.401 |
|
| 1987 |
Nukina N, Kosik KS, Selkoe DJ. Recognition of Alzheimer paired helical filaments by monoclonal neurofilament antibodies is due to crossreaction with tau protein. Proceedings of the National Academy of Sciences of the United States of America. 84: 3415-9. PMID 3106969 DOI: 10.1097/00002093-198701040-00025 |
0.668 |
|
| 1987 |
Selkoe DJ. Altered structural proteins in plaques and tangles: what do they tell us about the biology of Alzheimer's disease? Neurobiology of Aging. 7: 425-32. PMID 3104810 DOI: 10.1016/0197-4580(86)90055-2 |
0.457 |
|
| 1987 |
Joachim CL, Morris JH, Kosik KS, Selkoe DJ. Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders. Annals of Neurology. 22: 514-20. PMID 2963585 DOI: 10.1002/ana.410220411 |
0.417 |
|
| 1987 |
Podlisny MB, Lee G, Selkoe DJ. Gene dosage of the amyloid beta precursor protein in Alzheimer's disease. Science (New York, N.Y.). 238: 669-71. PMID 2960019 DOI: 10.1126/SCIENCE.2960019 |
0.44 |
|
| 1987 |
Eidelberg D, Sotrel A, Joachim C, Selkoe D, Forman A, Pendlebury WW, Perl DP. Adult onset Hallervorden-Spatz disease with neurofibrillary pathology. A discrete clinicopathological entity. Brain : a Journal of Neurology. 110: 993-1013. PMID 2888513 DOI: 10.1093/Brain/110.4.993 |
0.381 |
|
| 1987 |
Joachim CL, Morris JH, Selkoe DJ, Kosik KS. Tau epitopes are incorporated into a range of lesions in Alzheimer's disease. Journal of Neuropathology and Experimental Neurology. 46: 611-22. PMID 2443617 DOI: 10.1097/00005072-198711000-00001 |
0.591 |
|
| 1987 |
Neve RL, Selkoe DJ, Kurnit DM, Kosik KS. A cDNA for a human microtubule associated protein 2 epitope in the Alzheimer neurofibrillary tangle. Brain Research. 387: 193-6. PMID 2431745 DOI: 10.1016/0169-328X(86)90011-2 |
0.553 |
|
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