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Thomas C. Sudhof - Publications

Affiliations: 
Molecular and Cellular Physiology Stanford University, Palo Alto, CA 
 Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
 University Of Texas Sw Med Ctr/dallas 
Area:
Synapse
Website:
http://www.hhmi.org/scientists/thomas-c-sudhof
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Year Citation  Score
2024 Dai J, Aoto J, Südhof TC. Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. 112: 515-519. PMID 38330900 DOI: 10.1016/j.neuron.2024.01.012  0.711
2024 Sun W, Liu Z, Jiang X, Chen MB, Dong H, Liu J, Südhof TC, Quake SR. Spatial transcriptomics reveal neuron-astrocyte synergy in long-term memory. Nature. PMID 38326616 DOI: 10.1038/s41586-023-07011-6  0.756
2024 Wang S, DeLeon C, Sun W, Quake SR, Roth BL, Südhof TC. Alternative splicing of latrophilin-3 controls synapse formation. Nature. PMID 38233523 DOI: 10.1038/s41586-023-06913-9  0.807
2023 Plitt MH, Kaganovsky K, Südhof TC, Giocomo LM. Hippocampal place code plasticity in CA1 requires postsynaptic membrane fusion. Biorxiv : the Preprint Server For Biology. PMID 38045362 DOI: 10.1101/2023.11.20.567978  0.819
2023 Lai Y, Zhao C, Tian Z, Wang C, Fan J, Hu X, Tu J, Li T, Leitz J, Pfuetzner RA, Liu Z, Zhang S, Su Z, Burré J, Li D, et al. Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering. Proceedings of the National Academy of Sciences of the United States of America. 120: e2310174120. PMID 37883437 DOI: 10.1073/pnas.2310174120  0.516
2023 Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC. Correction: Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters. The Journal of Cell Biology. 222. PMID 37665610 DOI: 10.1083/jcb.20181207608242023c  0.826
2023 Sclip A, Südhof TC. Combinatorial expression of neurexins and LAR-type phosphotyrosine phosphatase receptors instructs assembly of a cerebellar circuit. Nature Communications. 14: 4976. PMID 37591863 DOI: 10.1038/s41467-023-40526-0  0.392
2023 Essayan-Perez S, Südhof TC. Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease. Neuron. PMID 37543038 DOI: 10.1016/j.neuron.2023.07.005  0.378
2023 Albarran E, Sun Y, Liu Y, Raju K, Dong A, Li Y, Wang S, Südhof TC, Ding JB. Postsynaptic synucleins mediate endocannabinoid signaling. Nature Neuroscience. PMID 37248337 DOI: 10.1038/s41593-023-01345-0  0.566
2023 Zhang X, Lin PY, Liakath-Ali K, Südhof TC. Author Correction: Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands. Nature Communications. 14: 2957. PMID 37221212 DOI: 10.1038/s41467-023-38713-0  0.338
2023 Südhof TC. Cerebellin-neurexin complexes instructing synapse properties. Current Opinion in Neurobiology. 81: 102727. PMID 37209532 DOI: 10.1016/j.conb.2023.102727  0.389
2023 Golf SR, Trotter JH, Nakahara G, Südhof TC. Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture. Biorxiv : the Preprint Server For Biology. PMID 37090508 DOI: 10.1101/2023.04.10.536254  0.768
2023 Trotter JH, Wang CY, Zhou P, Nakahara G, Südhof TC. A combinatorial code of neurexin-3 alternative splicing controls inhibitory synapses via a trans-synaptic dystroglycan signaling loop. Nature Communications. 14: 1771. PMID 36997523 DOI: 10.1038/s41467-023-36872-8  0.799
2023 Lin PY, Chen LY, Zhou P, Lee SJ, Trotter JH, Südhof TC. Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300363120. PMID 36961922 DOI: 10.1073/pnas.2300363120  0.842
2023 Hale WD, Südhof TC, Huganir RL. Engineered adhesion molecules drive synapse organization. Proceedings of the National Academy of Sciences of the United States of America. 120: e2215905120. PMID 36638214 DOI: 10.1073/pnas.2215905120  0.466
2023 Lin PY, Chen LY, Jiang M, Trotter JH, Seigneur E, Südhof TC. Neurexin-2: An inhibitory neurexin that restricts excitatory synapse formation in the hippocampus. Science Advances. 9: eadd8856. PMID 36608123 DOI: 10.1126/sciadv.add8856  0.857
2022 Haddad Derafshi B, Danko T, Chanda S, Batista PJ, Litzenburger U, Lee QY, Ng YH, Sebin A, Chang HY, Südhof TC, Wernig M. The autism risk factor CHD8 is a chromatin activator in human neurons and functionally dependent on the ERK-MAPK pathway effector ELK1. Scientific Reports. 12: 22425. PMID 36575212 DOI: 10.1038/s41598-022-23614-x  0.536
2022 Wang L, Mirabella VR, Dai R, Su X, Xu R, Jadali A, Bernabucci M, Singh I, Chen Y, Tian J, Jiang P, Kwan KY, Pak C, Liu C, Comoletti D, et al. Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism. Molecular Psychiatry. PMID 36280753 DOI: 10.1038/s41380-022-01834-x  0.677
2022 Dai J, Liakath-Ali K, Golf SR, Südhof TC. Distinct neurexin-cerebellin complexes control AMPA- and NMDA-receptor responses in a circuit-dependent manner. Elife. 11. PMID 36205393 DOI: 10.7554/eLife.78649  0.331
2022 Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K. Endocytosis in the axon initial segment maintains neuronal polarity. Nature. PMID 35978188 DOI: 10.1038/s41586-022-05074-5  0.476
2022 Han Y, Cao R, Qin L, Chen LY, Tang AH, Südhof TC, Zhang B. Neuroligin-3 confines AMPA receptors into nanoclusters, thereby controlling synaptic strength at the calyx of Held synapses. Science Advances. 8: eabo4173. PMID 35704570 DOI: 10.1126/sciadv.abo4173  0.588
2022 Burlingham SR, Wong NF, Peterkin L, Lubow L, Dos Santos Passos C, Benner O, Ghebrial M, Cast TP, Xu-Friedman MA, Südhof TC, Chanda S. Induction of synapse formation by de novo neurotransmitter synthesis. Nature Communications. 13: 3060. PMID 35650274 DOI: 10.1038/s41467-022-30756-z  0.816
2022 Liakath-Ali K, Polepalli JS, Lee SJ, Cloutier JF, Südhof TC. Transsynaptic cerebellin 4-neogenin 1 signaling mediates LTP in the mouse dentate gyrus. Proceedings of the National Academy of Sciences of the United States of America. 119: e2123421119. PMID 35544694 DOI: 10.1073/pnas.2123421119  0.852
2022 Zhang X, Lin PY, Liakath-Ali K, Südhof TC. Teneurins assemble into presynaptic nanoclusters that promote synapse formation via postsynaptic non-teneurin ligands. Nature Communications. 13: 2297. PMID 35484136 DOI: 10.1038/s41467-022-29751-1  0.462
2022 Liu Z, Jiang M, Liakath-Ali K, Sclip A, Ko J, Zhang RS, Südhof TC. Deletion of Calsyntenin-3, an atypical cadherin, suppresses inhibitory synapses but increases excitatory parallel-fiber synapses in cerebellum. Elife. 11. PMID 35420982 DOI: 10.7554/eLife.70664  0.854
2022 Alberts B, Colbran RJ, Dolphin AC, Pitt GS, Südhof TC. Proteolytic regulation of calcium channels - avoiding controversy. Faculty Reviews. 11: 5. PMID 35373215 DOI: 10.12703/r-01-000006  0.493
2022 Shibuya Y, Kumar KK, Mader MM, Yoo Y, Ayala LA, Zhou M, Mohr MA, Neumayer G, Kumar I, Yamamoto R, Marcoux P, Liou B, Bennett FC, Nakauchi H, Sun Y, et al. Treatment of a genetic brain disease by CNS-wide microglia replacement. Science Translational Medicine. 14: eabl9945. PMID 35294256 DOI: 10.1126/scitranslmed.abl9945  0.629
2022 Shankhwar S, Schwarz K, Katiyar R, Jung M, Maxeiner S, Südhof TC, Schmitz F. RIBEYE B-Domain Is Essential for RIBEYE A-Domain Stability and Assembly of Synaptic Ribbons. Frontiers in Molecular Neuroscience. 15: 838311. PMID 35153673 DOI: 10.3389/fnmol.2022.838311  0.683
2022 Sando R, Ho ML, Liu X, Südhof TC. Engineered synaptic tools reveal localized cAMP signaling in synapse assembly. The Journal of Cell Biology. 221. PMID 34913963 DOI: 10.1083/jcb.202109111  0.455
2021 Patzke C, Dai J, Brockmann MM, Sun Z, Fenske P, Rosenmund C, Südhof TC. CB1 receptor activation rapidly alters synaptic vesicle numbers in mouse hippocampal synapses. Molecular Psychiatry. 26: 6103. PMID 35031784 DOI: 10.1038/s41380-021-01426-1  0.777
2021 Wang CY, Trotter JH, Liakath-Ali K, Lee SJ, Liu X, Südhof TC. Molecular self-avoidance in synaptic neurexin complexes. Science Advances. 7: eabk1924. PMID 34919427 DOI: 10.1126/sciadv.abk1924  0.769
2021 Ng YH, Chanda S, Janas JA, Yang N, Kokubu Y, Südhof TC, Wernig M. Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics. Stem Cell Reports. PMID 34171286 DOI: 10.1016/j.stemcr.2021.05.017  0.643
2021 Dai J, Patzke C, Liakath-Ali K, Seigneur E, Südhof TC. GluD1 is a signal transduction device disguised as an ionotropic receptor. Nature. 595: 261-265. PMID 34135511 DOI: 10.1038/s41586-021-03661-6  0.798
2021 Südhof TC. The cell biology of synapse formation. The Journal of Cell Biology. 220. PMID 34086051 DOI: 10.1083/jcb.202103052  0.434
2021 Pak C, Danko T, Mirabella VR, Wang J, Liu Y, Vangipuram M, Grieder S, Zhang X, Ward T, Huang YA, Jin K, Dexheimer P, Bardes E, Mitelpunkt A, Ma J, et al. Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived -mutant neurons. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34035170 DOI: 10.1073/pnas.2025598118  0.763
2021 Patzke C, Dai J, Brockmann MM, Sun Z, Fenske P, Rosenmund C, Südhof TC. Cannabinoid receptor activation acutely increases synaptic vesicle numbers by activating synapsins in human synapses. Molecular Psychiatry. PMID 33931733 DOI: 10.1038/s41380-021-01095-0  0.86
2021 Luo F, Sclip A, Merrill S, Südhof TC. Neurexins regulate presynaptic GABA-receptors at central synapses. Nature Communications. 12: 2380. PMID 33888718 DOI: 10.1038/s41467-021-22753-5  0.664
2021 Liakath-Ali K, Südhof TC. The Perils of Navigating Activity-Dependent Alternative Splicing of Neurexins. Frontiers in Molecular Neuroscience. 14: 659681. PMID 33767611 DOI: 10.3389/fnmol.2021.659681  0.403
2021 Sando R, Südhof TC. Latrophilin GPCR signaling mediates synapse formation. Elife. 10. PMID 33646123 DOI: 10.7554/eLife.65717  0.477
2021 Mencacci NE, Brockmann MM, Dai J, Pajusalu S, Atasu B, Campos J, Pino G, Gonzalez-Latapi P, Patzke C, Schwake M, Tucci A, Pittman A, Simon-Sanchez J, Carvill GL, Balint B, et al. Bi-allelic variants in TSPOAP1, encoding the active zone protein RIMBP1, cause autosomal recessive dystonia. The Journal of Clinical Investigation. PMID 33539324 DOI: 10.1172/JCI140625  0.809
2021 Jiang X, Sando R, Südhof TC. Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33431662 DOI: 10.1073/pnas.2000173118  0.39
2020 Chen MB, Jiang X, Quake SR, Südhof TC. Persistent transcriptional programmes are associated with remote memory. Nature. PMID 33177708 DOI: 10.1038/s41586-020-2905-5  0.401
2020 Gan KJ, Südhof TC. SPARCL1 promotes excitatory but not inhibitory synapse formation and function independent of neurexins and neuroligins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32973045 DOI: 10.1523/JNEUROSCI.0454-20.2020  0.495
2020 Brockmann MM, Zarebidaki F, Camacho M, Grauel MK, Trimbuch T, Südhof TC, Rosenmund C. A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release. Cell Reports. 32: 107960. PMID 32755572 DOI: 10.1016/j.celrep.2020.107960  0.771
2020 Khalaj AJ, Sterky FH, Sclip A, Schwenk J, Brunger AT, Fakler B, Südhof TC. Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism. The Journal of Cell Biology. 219. PMID 32706374 DOI: 10.1083/jcb.202004164  0.638
2020 Zhou M, Melin MD, Xu W, Sudhof TC. Dysfunction of parvalbumin neurons in the cerebellar nuclei produces an action tremor. The Journal of Clinical Investigation. PMID 32634124 DOI: 10.1172/Jci135802  0.749
2020 Wang CY, Liu Z, Ng YH, Südhof TC. A Synaptic Circuit Required for Acquisition but Not Recall of Social Transmission of Food Preference. Neuron. PMID 32369733 DOI: 10.1016/J.Neuron.2020.04.004  0.57
2020 Li J, Xie Y, Cornelius S, Jiang X, Sando R, Kordon SP, Pan M, Leon K, Südhof TC, Zhao M, Araç D. Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism. Nature Communications. 11: 2140. PMID 32358586 DOI: 10.1038/S41467-020-16029-7  0.467
2020 Lee QY, Mall M, Chanda S, Zhou B, Sharma KS, Schaukowitch K, Adrian-Segarra JM, Grieder SD, Kareta MS, Wapinski OL, Ang CE, Li R, Südhof TC, Chang HY, Wernig M. Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes. Nature Cell Biology. PMID 32231311 DOI: 10.1038/S41556-020-0490-3  0.569
2020 Zhang RS, Liakath-Ali K, Südhof TC. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum. Elife. 9. PMID 32202499 DOI: 10.7554/Elife.54443  0.72
2020 Luo F, Sclip A, Jiang M, Südhof TC. Neurexins cluster Ca channels within the presynaptic active zone. The Embo Journal. e103208. PMID 32134527 DOI: 10.15252/Embj.2019103208  0.775
2020 Maxeiner S, Benseler F, Krasteva-Christ G, Brose N, Südhof TC. Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents. Molecular Biology and Evolution. PMID 32011705 DOI: 10.1093/molbev/msaa014  0.7
2020 Sclip A, Südhof TC. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. Elife. 9. PMID 31985401 DOI: 10.7554/eLife.53406  0.51
2020 Zhang RS, Liakath-Ali K, Südhof TC. Author response: Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum Elife. DOI: 10.7554/Elife.54443.Sa2  0.631
2019 Stanley G, Gokce O, Malenka RC, Südhof TC, Quake SR. Continuous and Discrete Neuron Types of the Adult Murine Striatum. Neuron. PMID 31813651 DOI: 10.1016/J.Neuron.2019.11.004  0.759
2019 Patzke C, Brockmann MM, Dai J, Gan KJ, Grauel MK, Fenske P, Liu Y, Acuna C, Rosenmund C, Südhof TC. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell. 179: 498-513.e22. PMID 31585084 DOI: 10.1016/J.Cell.2019.09.011  0.862
2019 Wilson SC, White KI, Zhou Q, Pfuetzner RA, Choi UB, Südhof TC, Brunger AT. Structures of neurexophilin-neurexin complexes reveal a regulatory mechanism of alternative splicing. The Embo Journal. e101603. PMID 31566781 DOI: 10.15252/Embj.2019101603  0.586
2019 Dong JX, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno CM, Sando R, Santana LF, Südhof TC, Gong B, Murray KD, Trimmer JS. A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in brain neurons. Elife. 8. PMID 31566565 DOI: 10.7554/Elife.48750  0.342
2019 Huang YA, Zhou B, Nabet AM, Wernig M, Südhof TC. Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31331998 DOI: 10.1523/Jneurosci.2994-18.2019  0.629
2019 Trotter JH, Hao J, Maxeiner S, Tsetsenis T, Liu Z, Zhuang X, Südhof TC. Synaptic neurexin-1 assembles into dynamically regulated active zone nanoclusters. The Journal of Cell Biology. PMID 31262725 DOI: 10.1083/Jcb.201812076  0.855
2019 Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, Kalani MYS, Südhof TC, Wernig M. Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons. Neuron. PMID 31257103 DOI: 10.1016/J.Neuron.2019.05.043  0.836
2019 Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, et al. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. PMID 31171447 DOI: 10.1016/J.Neuron.2019.05.002  0.827
2019 Liu Y, Sugiura Y, Südhof TC, Lin W. Ablation of all synaptobrevin vSNAREs blocks evoked but not spontaneous neurotransmitter release at neuromuscular synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31160536 DOI: 10.1523/Jneurosci.0403-19.2019  0.558
2019 Gan KJ, Südhof TC. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment. Proceedings of the National Academy of Sciences of the United States of America. PMID 31160442 DOI: 10.1073/pnas.1902672116  0.515
2019 Chanda S, Ang CE, Lee QY, Ghebrial M, Haag D, Shibuya Y, Wernig M, Südhof TC. Direct Reprogramming of Human Neurons Identifies MARCKSL1 as a Pathogenic Mediator of Valproic Acid-Induced Teratogenicity. Cell Stem Cell. PMID 31155484 DOI: 10.1016/J.Stem.2019.04.021  0.604
2019 Dai J, Aoto J, Südhof TC. Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses. Neuron. PMID 31005376 DOI: 10.1016/J.Neuron.2019.03.032  0.763
2019 Wu X, Morishita WK, Riley AM, Hale WD, Südhof TC, Malenka RC. Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways. Neuron. PMID 30871858 DOI: 10.1016/j.neuron.2019.02.013  0.817
2019 Shimojo M, Madara J, Pankow S, Liu X, Yates J, Südhof TC, Maximov A. Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity. Genes & Development. 33: 365-376. PMID 30808661 DOI: 10.1101/gad.320077.118  0.862
2019 Sando R, Jiang X, Südhof TC. Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins. Science (New York, N.Y.). 363. PMID 30792275 DOI: 10.1126/science.aav7969  0.554
2019 Hsu YT, Li J, Wu D, Südhof TC, Chen L. Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proceedings of the National Academy of Sciences of the United States of America. PMID 30782829 DOI: 10.1073/Pnas.1820690116  0.718
2018 Südhof TC. Towards an Understanding of Synapse Formation. Neuron. 100: 276-293. PMID 30359597 DOI: 10.1016/j.neuron.2018.09.040  0.556
2018 Zhong L, Chen X, Park E, Südhof TC, Chen L. Retinoic acid receptor RARα-dependent synaptic signaling mediates homeostatic synaptic plasticity at the inhibitory synapses of mouse visual cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30355624 DOI: 10.1523/Jneurosci.1133-18.2018  0.544
2018 Zhou M, Liu Z, Melin MD, Ng YH, Xu W, Südhof TC. A central amygdala to zona incerta projection is required for acquisition and remote recall of conditioned fear memory. Nature Neuroscience. PMID 30349111 DOI: 10.1038/S41593-018-0248-4  0.707
2018 Seigneur E, Polepalli JS, Südhof TC. Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. Proceedings of the National Academy of Sciences of the United States of America. PMID 30287486 DOI: 10.1073/pnas.1811086115  0.837
2018 Zhang Z, Marro SG, Zhang Y, Arendt KL, Patzke C, Zhou B, Fair T, Yang N, Südhof TC, Wernig M, Chen L. The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling. Science Translational Medicine. 10. PMID 30068571 DOI: 10.1126/Scitranslmed.Aar4338  0.839
2018 Sclip A, Acuna C, Luo F, Südhof TC. RIM-binding proteins recruit BK-channels to presynaptic release sites adjacent to voltage-gated Ca-channels. The Embo Journal. PMID 29967030 DOI: 10.15252/Embj.201798637  0.641
2018 Tanabe K, Ang CE, Chanda S, Olmos VH, Haag D, Levinson DF, Südhof TC, Wernig M. Transdifferentiation of human adult peripheral blood T cells into neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 29866841 DOI: 10.1073/Pnas.1720273115  0.578
2018 Bhouri M, Morishita W, Temkin P, Goswami D, Kawabe H, Brose N, Südhof TC, Craig AM, Siddiqui TJ, Malenka R. Deletion of in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 29784826 DOI: 10.1073/Pnas.1803280115  0.873
2018 Zhang B, Gokce O, Hale WD, Brose N, Südhof TC. Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses. The Journal of Experimental Medicine. PMID 29724786 DOI: 10.1084/Jem.20172162  0.822
2018 Seigneur E, Südhof TC. Genetic ablation of all cerebellins reveals synapse organizer functions in multiple regions throughout the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29691328 DOI: 10.1523/JNEUROSCI.0360-18.2018  0.511
2018 Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Südhof TC, Skiniotis G, Araç D. Structural Basis for Teneurin Function in Circuit-Wiring: A Toxin Motif at the Synapse. Cell. 173: 735-748.e15. PMID 29677516 DOI: 10.1016/J.Cell.2018.03.036  0.379
2018 Pak C, Grieder S, Yang N, Zhang Y, Wernig M, Sudhof T. Rapid generation of functional and homogeneous excitatory human forebrain neurons using Neurogenin-2 (Ngn2) Protocol Exchange. DOI: 10.1038/Protex.2018.082  0.362
2018 Zhou Q, Zhou P, Südhof TC, Brunger AT. Molecular Mechanisms Controlling Neurotransmitter Release by the Primed SNARE-complexin-Synaptotagmin Complex Biophysical Journal. 114: 554a-555a. DOI: 10.1016/J.Bpj.2017.11.3029  0.545
2017 Lissek T, Adams M, Adelman J, Ahissar E, Akaaboune M, Akil H, al'Absi M, Arain F, Arango-Lasprilla JC, Atasoy D, Avila J, Badawi A, Bading H, Baig AM, Baleriola J, et al. Building Bridges through Science. Neuron. 96: 730-735. PMID 29144972 DOI: 10.1016/J.Neuron.2017.09.028  0.711
2017 Südhof TC. Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits. Cell. 171: 745-769. PMID 29100073 DOI: 10.1016/j.cell.2017.10.024  0.502
2017 Anderson GR, Maxeiner S, Sando R, Tsetsenis T, Malenka RC, Südhof TC. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. The Journal of Cell Biology. PMID 28972101 DOI: 10.1083/Jcb.201703042  0.86
2017 Voleti R, Tomchick DR, Südhof TC, Rizo J. Exceptionally tight membrane-binding may explain the key role of the synaptotagmin-7 C2A domain in asynchronous neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923929 DOI: 10.1073/pnas.1710708114  0.354
2017 Luo F, Liu X, Südhof TC, Acuna C. Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca(2+) channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874522 DOI: 10.1073/Pnas.1702991114  0.708
2017 Zhou Q, Zhou P, Wang AL, Wu D, Zhao M, Südhof TC, Brunger AT. The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis. Nature. PMID 28813412 DOI: 10.1038/Nature23484  0.744
2017 Seigneur E, Südhof TC. Cerebellins Are Differentially Expressed in Selective Subsets of Neurons Throughout the Brain. The Journal of Comparative Neurology. PMID 28714144 DOI: 10.1002/cne.24278  0.46
2017 Liu Z, Chen Z, Shang C, Yan F, Shi Y, Zhang J, Qu B, Han H, Wang Y, Li D, Südhof TC, Cao P. IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning. Neuron. 95: 106-122.e5. PMID 28683263 DOI: 10.1016/J.Neuron.2017.06.015  0.807
2017 Chanda S, Hale WD, Zhang B, Wernig M, Südhof TC. Unique vs. Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28607166 DOI: 10.1523/Jneurosci.0125-17.2017  0.744
2017 Chew KS, Fernandez DC, Hattar S, Südhof TC, Martinelli DC. Anatomical and Behavioral Investigation of C1ql3 in the Mouse Suprachiasmatic Nucleus. Journal of Biological Rhythms. 748730417704766. PMID 28553739 DOI: 10.1177/0748730417704766  0.613
2017 Luo F, Südhof TC. Synaptotagmin-7-Mediated Asynchronous Release Boosts High-Fidelity Synchronous Transmission at a Central Synapse. Neuron. 94: 826-839.e3. PMID 28521135 DOI: 10.1016/J.Neuron.2017.04.020  0.724
2017 Yang N, Chanda S, Marro S, Ng YH, Janas JA, Haag D, Ang CE, Tang Y, Flores Q, Mall M, Wapinski O, Li M, Ahlenius H, Rubenstein JL, Chang HY, et al. Generation of pure GABAergic neurons by transcription factor programming. Nature Methods. PMID 28504679 DOI: 10.1038/Nmeth.4291  0.637
2017 Chen LY, Jiang M, Zhang B, Gokce O, Südhof TC. Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. Neuron. 94: 611-625.e4. PMID 28472659 DOI: 10.1016/J.Neuron.2017.04.011  0.847
2017 Mall M, Kareta MS, Chanda S, Ahlenius H, Perotti N, Zhou B, Grieder SD, Ge X, Drake S, Euong Ang C, Walker BM, Vierbuchen T, Fuentes DR, Brennecke P, Nitta KR, et al. Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates. Nature. PMID 28379941 DOI: 10.1038/Nature21722  0.586
2017 Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, Chen L, Malenka RC, Südhof TC. Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Nature. PMID 28355182 DOI: 10.1038/Nature21720  0.846
2017 Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Cooper BH, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, et al. Correction: ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. The Journal of Cell Biology. PMID 28289090 DOI: 10.1083/jcb.20160608603092017c  0.835
2017 Kawabe H, Mitkovski M, Kaeser PS, Hirrlinger J, Opazo F, Nestvogel D, Kalla S, Fejtova A, Verrier SE, Bungers SR, Varoqueaux F, Wang Y, Nehring RB, Gundelfinger ED, Rosenmund C, et al. ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones. The Journal of Cell Biology. PMID 28264913 DOI: 10.1083/Jcb.201606086  0.857
2017 Sterky FH, Trotter JH, Lee SJ, Recktenwald CV, Du X, Zhou B, Zhou P, Schwenk J, Fakler B, Südhof TC. Carbonic anhydrase-related protein CA10 is an evolutionarily conserved pan-neurexin ligand. Proceedings of the National Academy of Sciences of the United States of America. PMID 28154140 DOI: 10.1073/Pnas.1621321114  0.783
2017 Huang YA, Zhou B, Wernig M, Südhof TC. ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion. Cell. PMID 28111074 DOI: 10.1016/J.Cell.2016.12.044  0.614
2017 Polepalli JS, Wu H, Goswami D, Halpern CH, Südhof TC, Malenka RC. Modulation of excitation on parvalbumin interneurons by neuroligin-3 regulates the hippocampal network. Nature Neuroscience. PMID 28067903 DOI: 10.1038/Nn.4471  0.85
2016 Lee SJ, Wei M, Zhang C, Maxeiner S, Pak C, Calado Botelho S, Trotter J, Sterky FH, Südhof TC. Presynaptic neuronal pentraxin receptor organizes excitatory and inhibitory synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27986928 DOI: 10.1523/Jneurosci.2768-16.2016  0.86
2016 Gong J, Lai Y, Li X, Wang M, Leitz J, Hu Y, Zhang Y, Choi UB, Cipriano D, Pfuetzner RA, Südhof TC, Yang X, Brunger AT, Diao J. C-terminal domain of mammalian complexin-1 localizes to highly curved membranes. Proceedings of the National Academy of Sciences of the United States of America. 113: E7590-E7599. PMID 27821736 DOI: 10.1073/Pnas.1609917113  0.619
2016 Zhang B, Seigneur E, Wei P, Gokce O, Morgan J, Südhof TC. Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held. Molecular Psychiatry. PMID 27725662 DOI: 10.1038/Mp.2016.157  0.772
2016 Zhang B, Südhof TC. Neuroligins Are Selectively Essential for NMDAR Signaling in Cerebellar Stellate Interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9070-83. PMID 27581450 DOI: 10.1523/JNEUROSCI.1356-16.2016  0.564
2016 Acuna C, Liu X, Südhof TC. How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs. Neuron. 91: 792-807. PMID 27537484 DOI: 10.1016/j.neuron.2016.07.042  0.51
2016 Földy C, Darmanis S, Aoto J, Malenka RC, Quake SR, Südhof TC. Single-cell RNAseq reveals cell adhesion molecule profiles in electrophysiologically defined neurons. Proceedings of the National Academy of Sciences of the United States of America. 113: E5222-31. PMID 27531958 DOI: 10.1073/Pnas.1610155113  0.822
2016 Martinelli DC, Chew KS, Rohlmann A, Lum MY, Ressl S, Hattar S, Brunger AT, Missler M, Südhof TC. Expression of C1ql3 in Discrete Neuronal Populations Controls Efferent Synapse Numbers and Diverse Behaviors. Neuron. 91: 1034-51. PMID 27478018 DOI: 10.1016/J.Neuron.2016.07.002  0.847
2016 Gokce O, Stanley GM, Treutlein B, Neff NF, Camp JG, Malenka RC, Rothwell PE, Fuccillo MV, Südhof TC, Quake SR. Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq. Cell Reports. 16: 1126-37. PMID 27425622 DOI: 10.1016/J.Celrep.2016.06.059  0.788
2016 Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Südhof TC, Wernig M. FoxO3 regulates neuronal reprogramming of cells from postnatal and aging mice. Proceedings of the National Academy of Sciences of the United States of America. 113: 8514-9. PMID 27402759 DOI: 10.1073/Pnas.1607079113  0.592
2016 Sclip A, Bacaj T, Giam LR, Südhof TC. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. Plos One. 11: e0158295. PMID 27348751 DOI: 10.1371/journal.pone.0158295  0.395
2016 Jiang M, Polepalli J, Chen LY, Zhang B, Südhof TC, Malenka RC. Conditional ablation of neuroligin-1 in CA1 pyramidal neurons blocks LTP by a cell-autonomous NMDA receptor-independent mechanism. Molecular Psychiatry. PMID 27217145 DOI: 10.1038/Mp.2016.80  0.864
2016 Patzke C, Südhof TC. The conditional KO approach: Cre/Lox technology in human neurons. Rare Diseases (Austin, Tex.). 4: e1131884. PMID 27141410 DOI: 10.1080/21675511.2015.1131884  0.756
2016 Patzke C, Acuna C, Giam LR, Wernig M, Südhof TC. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation. The Journal of Experimental Medicine. 213: 499-515. PMID 27001749 DOI: 10.1084/Jem.20150951  0.785
2016 Yi F, Danko T, Botelho SC, Patzke C, Pak C, Wernig M, Südhof TC. Autism-associated SHANK3 haploinsufficiency causes Ih channelopathy in human neurons. Science (New York, N.Y.). 352: aaf2669. PMID 26966193 DOI: 10.1126/Science.Aaf2669  0.814
2016 Maxeiner S, Luo F, Tan A, Schmitz F, Südhof TC. How to make a synaptic ribbon: RIBEYE deletion abolishes ribbons in retinal synapses and disrupts neurotransmitter release. The Embo Journal. 35: 1098-114. PMID 26929012 DOI: 10.15252/embj.201592701  0.835
2015 De Filippis L, Südhof TC, Pang ZP. Harness the power of endogenous neural stem cells by biomaterials to treat spinal cord injury. Science China. Life Sciences. 58: 1167-8. PMID 26481248 DOI: 10.1007/s11427-015-4943-z  0.452
2015 Bacaj T, Wu D, Burré J, Malenka RC, Liu X, Südhof TC. Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles. Plos Biology. 13: e1002267. PMID 26437117 DOI: 10.1371/Journal.Pbio.1002267  0.742
2015 Acuna C, Liu X, Gonzalez A, Südhof TC. RIM-BPs Mediate Tight Coupling of Action Potentials to Ca(2+)-Triggered Neurotransmitter Release. Neuron. 87: 1234-47. PMID 26402606 DOI: 10.1016/j.neuron.2015.08.027  0.529
2015 Yang X, Pei J, Kaeser-Woo YJ, Bacaj T, Grishin NV, Südhof TC. Evolutionary conservation of complexins: from choanoflagellates to mice. Embo Reports. 16: 1308-17. PMID 26338476 DOI: 10.15252/Embr.201540305  0.857
2015 Zhang B, Chen LY, Liu X, Maxeiner S, Lee SJ, Gokce O, Südhof TC. Neuroligins Sculpt Cerebellar Purkinje-Cell Circuits by Differential Control of Distinct Classes of Synapses. Neuron. 87: 781-96. PMID 26291161 DOI: 10.1016/J.Neuron.2015.07.020  0.833
2015 Liu Y, Li H, Sugiura Y, Han W, Gallardo G, Khvotchev M, Zhang Y, Kavalali ET, Südhof TC, Lin W. Ubiquitin-Synaptobrevin Fusion Protein Causes Degeneration of Presynaptic Motor Terminals in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11514-31. PMID 26290230 DOI: 10.1523/Jneurosci.5288-14.2015  0.829
2015 Patzke C, Han Y, Covy J, Yi F, Maxeiner S, Wernig M, Südhof TC. Analysis of conditional heterozygous STXBP1 mutations in human neurons. The Journal of Clinical Investigation. 125: 3560-71. PMID 26280581 DOI: 10.1172/Jci78612  0.808
2015 Zhou Q, Lai Y, Bacaj T, Zhao M, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, et al. Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis. Nature. 525: 62-7. PMID 26280336 DOI: 10.1038/Nature14975  0.637
2015 Pak C, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, Südhof TC. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused by Heterozygous Mutations in NRXN1. Cell Stem Cell. 17: 316-28. PMID 26279266 DOI: 10.1016/J.Stem.2015.07.017  0.834
2015 Luo F, Bacaj T, Südhof TC. Synaptotagmin-7 Is Essential for Ca2+-Triggered Delayed Asynchronous Release But Not for Ca2+-Dependent Vesicle Priming in Retinal Ribbon Synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11024-33. PMID 26245964 DOI: 10.1523/JNEUROSCI.0759-15.2015  0.694
2015 Lu YC, Nazarko OV, Sando R, Salzman GS, Südhof TC, Araç D. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure (London, England : 1993). 23: 1678-91. PMID 26235030 DOI: 10.1016/j.str.2015.06.024  0.444
2015 Wu B, Wei S, Petersen N, Ali Y, Wang X, Bacaj T, Rorsman P, Hong W, Südhof TC, Han W. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 9996-10001. PMID 26216970 DOI: 10.1073/Pnas.1513004112  0.785
2015 Anderson GR, Aoto J, Tabuchi K, Földy C, Covy J, Yee AX, Wu D, Lee SJ, Chen L, Malenka RC, Südhof TC. β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 162: 593-606. PMID 26213384 DOI: 10.1016/J.Cell.2015.06.056  0.837
2015 Fuccillo MV, Földy C, Gökce Ö, Rothwell PE, Sun GL, Malenka RC, Südhof TC. Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms. Neuron. 87: 326-40. PMID 26182417 DOI: 10.1016/J.Neuron.2015.06.028  0.816
2015 Brewer KD, Bacaj T, Cavalli A, Camilloni C, Swarbrick JD, Liu J, Zhou A, Zhou P, Barlow N, Xu J, Seven AB, Prinslow EA, Voleti R, Häussinger D, Bonvin AM, et al. Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution. Nature Structural & Molecular Biology. 22: 555-64. PMID 26030874 DOI: 10.1038/Nsmb.3035  0.369
2015 Aoto J, Földy C, Ilcus SM, Tabuchi K, Südhof TC. Distinct circuit-dependent functions of presynaptic neurexin-3 at GABAergic and glutamatergic synapses. Nature Neuroscience. 18: 997-1007. PMID 26030848 DOI: 10.1038/Nn.4037  0.8
2015 Bacaj T, Ahmad M, Jurado S, Malenka RC, Südhof TC. Synaptic Function of Rab11Fip5: Selective Requirement for Hippocampal Long-Term Depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7460-74. PMID 25972173 DOI: 10.1523/Jneurosci.1581-14.2015  0.797
2015 Arendt KL, Zhang Y, Jurado S, Malenka RC, Südhof TC, Chen L. Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms. Neuron. 86: 442-56. PMID 25843403 DOI: 10.1016/J.Neuron.2015.03.009  0.639
2015 Liang J, Xu W, Hsu YT, Yee AX, Chen L, Südhof TC. Conditional neuroligin-2 knockout in adult medial prefrontal cortex links chronic changes in synaptic inhibition to cognitive impairments. Molecular Psychiatry. 20: 850-9. PMID 25824299 DOI: 10.1038/Mp.2015.31  0.578
2015 Chanda S, Aoto J, Lee SJ, Wernig M, Südhof TC. Pathogenic mechanism of an autism-associated neuroligin mutation involves altered AMPA-receptor trafficking. Molecular Psychiatry. PMID 25778475 DOI: 10.1038/Mp.2015.20  0.836
2015 Ressl S, Vu BK, Vivona S, Martinelli DC, Südhof TC, Brunger AT. Structures of C1q-like proteins reveal unique features among the C1q/TNF superfamily. Structure (London, England : 1993). 23: 688-99. PMID 25752542 DOI: 10.1016/J.Str.2015.01.019  0.804
2015 Han Y, Babai N, Kaeser P, Südhof TC, Schneggenburger R. RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse. Journal of Neurophysiology. 113: 255-63. PMID 25343783 DOI: 10.1152/Jn.00488.2014  0.733
2015 Bacaj T, Ahmad M, Jurado S, Malenka RC, Südhof TC. Synaptic function of Rab11Fip5: Selective requirement for hippocampal long-term depression Journal of Neuroscience. 35: 7460-7474. DOI: 10.1523/JNEUROSCI.1581-14.2015  0.701
2015 Wu B, Wei S, Petersen N, Ali Y, Wang X, Bacaj T, Rorsman P, Hong W, Südhof TC, Han W. Synaptotagmin-7 phosphorylation mediates GLP-1-dependent potentiation of insulin secretion from β-cells Proceedings of the National Academy of Sciences of the United States of America. 112: 9996-10001. DOI: 10.1073/pnas.1513004112  0.75
2015 Fuccillo MV, Földy C, Gökce Ö, Rothwell PE, Sun GL, Malenka RC, Südhof TC. Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms Neuron. 87: 326-341. DOI: 10.1016/j.neuron.2015.06.028  0.771
2014 Tsetsenis T, Boucard AA, Araç D, Brunger AT, Südhof TC. Direct visualization of trans-synaptic neurexin-neuroligin interactions during synapse formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15083-96. PMID 25378172 DOI: 10.1523/Jneurosci.0348-14.2014  0.852
2014 Imig C, Min SW, Krinner S, Arancillo M, Rosenmund C, Südhof TC, Rhee J, Brose N, Cooper BH. The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Neuron. 84: 416-31. PMID 25374362 DOI: 10.1016/J.Neuron.2014.10.009  0.831
2014 Südhof TC. The molecular machinery of neurotransmitter release (Nobel lecture). Angewandte Chemie (International Ed. in English). 53: 12696-717. PMID 25339369 DOI: 10.1002/anie.201406359  0.469
2014 Chanda S, Ang CE, Davila J, Pak C, Mall M, Lee QY, Ahlenius H, Jung SW, Südhof TC, Wernig M. Generation of induced neuronal cells by the single reprogramming factor ASCL1. Stem Cell Reports. 3: 282-96. PMID 25254342 DOI: 10.1016/J.Stemcr.2014.05.020  0.599
2014 Liu C, Bickford LS, Held RG, Nyitrai H, Südhof TC, Kaeser PS. The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12289-303. PMID 25209271 DOI: 10.1523/JNEUROSCI.0999-14.2014  0.768
2014 Rothwell PE, Fuccillo MV, Maxeiner S, Hayton SJ, Gokce O, Lim BK, Fowler SC, Malenka RC, Südhof TC. Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors. Cell. 158: 198-212. PMID 24995986 DOI: 10.1016/J.Cell.2014.04.045  0.816
2014 Acuna C, Guo Q, Burré J, Sharma M, Sun J, Südhof TC. Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²⁺ sensitivity. Neuron. 82: 1088-100. PMID 24908488 DOI: 10.1016/J.Neuron.2014.04.020  0.46
2014 Lee SH, Sharma M, Südhof TC, Shen J. Synaptic function of nicastrin in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 111: 8973-8. PMID 24889619 DOI: 10.1073/Pnas.1408554111  0.546
2014 Treutlein B, Gokce O, Quake SR, Südhof TC. Cartography of neurexin alternative splicing mapped by single-molecule long-read mRNA sequencing. Proceedings of the National Academy of Sciences of the United States of America. 111: E1291-9. PMID 24639501 DOI: 10.1073/Pnas.1403244111  0.724
2014 Um JW, Pramanik G, Ko JS, Song MY, Lee D, Kim H, Park KS, Südhof TC, Tabuchi K, Ko J. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Cell Reports. 6: 1096-109. PMID 24613359 DOI: 10.1016/J.Celrep.2014.02.010  0.767
2014 Boucard AA, Maxeiner S, Südhof TC. Latrophilins function as heterophilic cell-adhesion molecules by binding to teneurins: regulation by alternative splicing. The Journal of Biological Chemistry. 289: 387-402. PMID 24273166 DOI: 10.1074/jbc.M113.504779  0.705
2014 Pak CH, Danko T, Zhang Y, Aoto J, Anderson G, Maxeiner S, Yi F, Wernig M, Südhof TC. Human Neuropsychiatric Disease Modeling using Conditional Deletion Reveals Synaptic Transmission Defects Caused By Heterozygous Mutations in NRXN1 Cell Stem Cell. DOI: 10.1016/j.stem.2015.07.017  0.814
2013 Yang X, Cao P, Südhof TC. Deconstructing complexin function in activating and clamping Ca2+-triggered exocytosis by comparing knockout and knockdown phenotypes. Proceedings of the National Academy of Sciences of the United States of America. 110: 20777-82. PMID 24297916 DOI: 10.1073/pnas.1321367110  0.657
2013 Bacaj T, Wu D, Yang X, Morishita W, Zhou P, Xu W, Malenka RC, Südhof TC. Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release. Neuron. 80: 947-59. PMID 24267651 DOI: 10.1016/J.Neuron.2013.10.026  0.825
2013 Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro DS, Webb AE, Südhof TC, et al. Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell. 155: 621-35. PMID 24243019 DOI: 10.1016/J.Cell.2013.09.028  0.56
2013 Südhof TC. Neurotransmitter release: the last millisecond in the life of a synaptic vesicle. Neuron. 80: 675-90. PMID 24183019 DOI: 10.1016/j.neuron.2013.10.022  0.508
2013 Arancillo M, Min SW, Gerber S, Münster-Wandowski A, Wu YJ, Herman M, Trimbuch T, Rah JC, Ahnert-Hilger G, Riedel D, Südhof TC, Rosenmund C. Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16698-714. PMID 24133272 DOI: 10.1523/Jneurosci.0187-13.2013  0.784
2013 Zhou P, Bacaj T, Yang X, Pang ZP, Südhof TC. Lipid-anchored SNAREs lacking transmembrane regions fully support membrane fusion during neurotransmitter release. Neuron. 80: 470-83. PMID 24120845 DOI: 10.1016/j.neuron.2013.09.010  0.622
2013 Chanda S, Marro S, Wernig M, Südhof TC. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proceedings of the National Academy of Sciences of the United States of America. 110: 16622-7. PMID 24046374 DOI: 10.1073/Pnas.1316240110  0.672
2013 Gokce O, Südhof TC. Membrane-tethered monomeric neurexin LNS-domain triggers synapse formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 14617-28. PMID 24005312 DOI: 10.1523/Jneurosci.1232-13.2013  0.76
2013 Soler-Llavina GJ, Arstikaitis P, Morishita W, Ahmad M, Südhof TC, Malenka RC. Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron. 79: 439-46. PMID 23931994 DOI: 10.1016/J.Neuron.2013.06.007  0.872
2013 Aoto J, Martinelli DC, Malenka RC, Tabuchi K, Südhof TC. Presynaptic neurexin-3 alternative splicing trans-synaptically controls postsynaptic AMPA receptor trafficking. Cell. 154: 75-88. PMID 23827676 DOI: 10.1016/J.Cell.2013.05.060  0.843
2013 Pertsinidis A, Mukherjee K, Sharma M, Pang ZP, Park SR, Zhang Y, Brunger AT, Südhof TC, Chu S. Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ. Proceedings of the National Academy of Sciences of the United States of America. 110: E2812-20. PMID 23821748 DOI: 10.1073/Pnas.1310654110  0.703
2013 Burré J, Vivona S, Diao J, Sharma M, Brunger AT, Südhof TC. Properties of native brain α-synuclein. Nature. 498: E4-6; discussion E6-. PMID 23765500 DOI: 10.1038/Nature12125  0.513
2013 Zhang Y, Pak C, Han Y, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C, Acuna C, Covy J, Xu W, Yang N, Danko T, Chen L, Wernig M, et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron. 78: 785-98. PMID 23764284 DOI: 10.1016/J.Neuron.2013.05.029  0.808
2013 Kaeser-Woo YJ, Younts TJ, Yang X, Zhou P, Wu D, Castillo PE, Südhof TC. Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9769-80. PMID 23739973 DOI: 10.1523/Jneurosci.5814-12.2013  0.844
2013 Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT. Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2. Elife. 2: e00592. PMID 23638301 DOI: 10.7554/Elife.00592  0.618
2013 Földy C, Malenka RC, Südhof TC. Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron. 78: 498-509. PMID 23583622 DOI: 10.1016/j.neuron.2013.02.036  0.644
2013 Davila J, Chanda S, Ang CE, Südhof TC, Wernig M. Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. Journal of Neuroscience Methods. 216: 104-9. PMID 23562599 DOI: 10.1016/J.Jneumeth.2013.03.020  0.541
2013 Jurado S, Goswami D, Zhang Y, Molina AJ, Südhof TC, Malenka RC. LTP requires a unique postsynaptic SNARE fusion machinery. Neuron. 77: 542-58. PMID 23395379 DOI: 10.1016/J.Neuron.2012.11.029  0.657
2013 Cao P, Yang X, Südhof TC. Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1714-27. PMID 23345244 DOI: 10.1523/JNEUROSCI.4087-12.2013  0.7
2013 Lee K, Kim Y, Lee SJ, Qiang Y, Lee D, Lee HW, Kim H, Je HS, Südhof TC, Ko J. MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development. Proceedings of the National Academy of Sciences of the United States of America. 110: 336-41. PMID 23248271 DOI: 10.1073/pnas.1219987110  0.764
2013 Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC. Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. The Embo Journal. 32: 159-71. PMID 23188083 DOI: 10.1038/emboj.2012.307  0.784
2013 Diao J, Burré J, Vivona S, Cipriano DJ, Sharma M, Kyoung M, Südhof TC, Brunger AT. Author response: Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2 Elife. DOI: 10.7554/Elife.00592.014  0.408
2012 Burré J, Sharma M, Südhof TC. Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15227-42. PMID 23100443 DOI: 10.1523/Jneurosci.3545-12.2012  0.393
2012 Anderson GR, Galfin T, Xu W, Aoto J, Malenka RC, Südhof TC. Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development. Proceedings of the National Academy of Sciences of the United States of America. 109: 18120-5. PMID 23074245 DOI: 10.1073/Pnas.1216398109  0.827
2012 Rizo J, Südhof TC. The membrane fusion enigma: SNAREs, Sec1/Munc18 proteins, and their accomplices--guilty as charged? Annual Review of Cell and Developmental Biology. 28: 279-308. PMID 23057743 DOI: 10.1146/annurev-cellbio-101011-155818  0.399
2012 Sharma M, Burré J, Südhof TC. Proteasome inhibition alleviates SNARE-dependent neurodegeneration. Science Translational Medicine. 4: 147ra113. PMID 22896677 DOI: 10.1126/Scitranslmed.3004028  0.318
2012 Südhof TC. The presynaptic active zone. Neuron. 75: 11-25. PMID 22794257 DOI: 10.1016/j.neuron.2012.06.012  0.521
2012 Yang SN, Shi Y, Yang G, Li Y, Yu L, Shin OH, Bacaj T, Südhof TC, Yu J, Berggren PO. Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron. Proceedings of the National Academy of Sciences of the United States of America. 109: 12183-8. PMID 22778403 DOI: 10.1073/pnas.1115070109  0.497
2012 Kaeser PS, Deng L, Fan M, Südhof TC. RIM genes differentially contribute to organizing presynaptic release sites. Proceedings of the National Academy of Sciences of the United States of America. 109: 11830-5. PMID 22753485 DOI: 10.1073/pnas.1209318109  0.691
2012 Narboux-Nême N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Lainé J, Rossier J, Ropert N, Südhof TC, Gaspar P. Neurotransmitter release at the thalamocortical synapse instructs barrel formation but not axon patterning in the somatosensory cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6183-96. PMID 22553025 DOI: 10.1523/Jneurosci.0343-12.2012  0.746
2012 Sheng M, Sabatini BL, Südhof TC. Synapses and Alzheimer's disease. Cold Spring Harbor Perspectives in Biology. 4. PMID 22491782 DOI: 10.1101/cshperspect.a005777  0.311
2012 Xu W, Morishita W, Buckmaster PS, Pang ZP, Malenka RC, Südhof TC. Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron. 73: 990-1001. PMID 22405208 DOI: 10.1016/j.neuron.2011.12.036  0.813
2012 Kaeser-Woo YJ, Yang X, Südhof TC. C-terminal complexin sequence is selectively required for clamping and priming but not for Ca2+ triggering of synaptic exocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2877-85. PMID 22357870 DOI: 10.1523/JNEUROSCI.3360-11.2012  0.837
2012 Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT. A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis. The Embo Journal. 31: 1364-78. PMID 22333914 DOI: 10.1038/emboj.2012.26  0.536
2012 Lujan E, Chanda S, Ahlenius H, Südhof TC, Wernig M. Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 2527-32. PMID 22308465 DOI: 10.1073/Pnas.1121003109  0.582
2012 Ahmad M, Polepalli JS, Goswami D, Yang X, Kaeser-Woo YJ, Südhof TC, Malenka RC. Postsynaptic complexin controls AMPA receptor exocytosis during LTP. Neuron. 73: 260-7. PMID 22284181 DOI: 10.1016/J.Neuron.2011.11.020  0.851
2012 Missler M, Südhof TC, Biederer T. Synaptic cell adhesion. Cold Spring Harbor Perspectives in Biology. 4: a005694. PMID 22278667 DOI: 10.1101/Cshperspect.A005694  0.835
2012 Boucard AA, Ko J, Südhof TC. High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex. The Journal of Biological Chemistry. 287: 9399-413. PMID 22262843 DOI: 10.1074/jbc.M111.318659  0.687
2012 Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC. CSPα knockout causes neurodegeneration by impairing SNAP-25 function. The Embo Journal. 31: 829-41. PMID 22187053 DOI: 10.1038/Emboj.2011.467  0.415
2012 Haws ME, Kaeser PS, Jarvis DL, Südhof TC, Powell CM. Region-specific deletions of RIM1 reproduce a subset of global RIM1α(-/-) phenotypes. Genes, Brain, and Behavior. 11: 201-13. PMID 22103334 DOI: 10.1111/j.1601-183X.2011.00755.x  0.759
2012 Südhof TC. Calcium control of neurotransmitter release. Cold Spring Harbor Perspectives in Biology. 4: a011353. PMID 22068972 DOI: 10.1101/cshperspect.a011353  0.435
2012 Polepalli JS, Ahmad M, Goswami D, Yang X, Kaeser‐Woo YJ, Südhof TC, Malenka RC. ISDN2012_0286: Postsynaptic complexin controls AMPA receptor exocytosis during long term potentiation International Journal of Developmental Neuroscience. 30: 689-689. DOI: 10.1016/J.Ijdevneu.2012.10.057  0.798
2011 Citri A, Pang ZP, Südhof TC, Wernig M, Malenka RC. Comprehensive qPCR profiling of gene expression in single neuronal cells. Nature Protocols. 7: 118-27. PMID 22193304 DOI: 10.1038/Nprot.2011.430  0.642
2011 Yang N, Ng YH, Pang ZP, Südhof TC, Wernig M. Induced neuronal cells: how to make and define a neuron. Cell Stem Cell. 9: 517-25. PMID 22136927 DOI: 10.1016/J.Stem.2011.11.015  0.571
2011 Südhof TC, Rizo J. Synaptic vesicle exocytosis. Cold Spring Harbor Perspectives in Biology. 3. PMID 22026965 DOI: 10.1101/cshperspect.a005637  0.459
2011 Marro S, Pang ZP, Yang N, Tsai MC, Qu K, Chang HY, Südhof TC, Wernig M. Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell. 9: 374-82. PMID 21962918 DOI: 10.1016/J.Stem.2011.09.002  0.545
2011 Soler-Llavina GJ, Fuccillo MV, Ko J, Südhof TC, Malenka RC. The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 16502-9. PMID 21953696 DOI: 10.1073/Pnas.1114028108  0.863
2011 Tsetsenis T, Younts TJ, Chiu CQ, Kaeser PS, Castillo PE, Südhof TC. Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning. Proceedings of the National Academy of Sciences of the United States of America. 108: 14300-5. PMID 21844341 DOI: 10.1073/Pnas.1112237108  0.842
2011 Etherton M, Földy C, Sharma M, Tabuchi K, Liu X, Shamloo M, Malenka RC, Südhof TC. Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proceedings of the National Academy of Sciences of the United States of America. 108: 13764-9. PMID 21808020 DOI: 10.1073/Pnas.1111093108  0.669
2011 Ko J, Soler-Llavina GJ, Fuccillo MV, Malenka RC, Südhof TC. Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. The Journal of Cell Biology. 194: 323-34. PMID 21788371 DOI: 10.1083/jcb.201101072  0.868
2011 Etherton MR, Tabuchi K, Sharma M, Ko J, Südhof TC. An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. The Embo Journal. 30: 2908-19. PMID 21642956 DOI: 10.1038/Emboj.2011.182  0.764
2011 Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M. Induction of human neuronal cells by defined transcription factors. Nature. 476: 220-3. PMID 21617644 DOI: 10.1038/Nature10202  0.563
2011 Pang ZP, Bacaj T, Yang X, Zhou P, Xu W, Südhof TC. Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism. Neuron. 70: 244-51. PMID 21521611 DOI: 10.1016/j.neuron.2011.03.011  0.647
2011 Cao P, Maximov A, Südhof TC. Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10. Cell. 145: 300-11. PMID 21496647 DOI: 10.1016/j.cell.2011.03.034  0.768
2011 Martinelli DC, Südhof TC. Cerebellins meet neurexins (Commentary on Matsuda & Yuzaki). The European Journal of Neuroscience. 33: 1445-6. PMID 21496123 DOI: 10.1111/j.1460-9568.2011.07665.x  0.517
2011 Bolliger MF, Martinelli DC, Südhof TC. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Proceedings of the National Academy of Sciences of the United States of America. 108: 2534-9. PMID 21262840 DOI: 10.1073/pnas.1019577108  0.618
2011 Deng L, Kaeser PS, Xu W, Südhof TC. RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13. Neuron. 69: 317-31. PMID 21262469 DOI: 10.1016/j.neuron.2011.01.005  0.742
2011 Han Y, Kaeser PS, Südhof TC, Schneggenburger R. RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone. Neuron. 69: 304-16. PMID 21262468 DOI: 10.1016/J.Neuron.2010.12.014  0.694
2011 Kaeser PS, Deng L, Wang Y, Dulubova I, Liu X, Rizo J, Südhof TC. RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction. Cell. 144: 282-95. PMID 21241895 DOI: 10.1016/j.cell.2010.12.029  0.699
2011 Sharma M, Burré J, Südhof TC. CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity. Nature Cell Biology. 13: 30-9. PMID 21151134 DOI: 10.1038/Ncb2131  0.502
2011 Ko J, Sudhof TC. Activity-dependent synapse validation by neurexin ligands, LRRTMs and neuroligins Neuroscience Research. 71. DOI: 10.1016/J.Neures.2011.07.071  0.419
2010 Bacaj T, Pang ZP, Südhof TC. Testing the SNARE/SM protein model of membrane fusion. Proceedings of the National Academy of Sciences of the United States of America. 107: 22365-6. PMID 21169506 DOI: 10.1073/pnas.1017268108  0.543
2010 Yang X, Kaeser-Woo YJ, Pang ZP, Xu W, Südhof TC. Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix. Neuron. 68: 907-20. PMID 21145004 DOI: 10.1016/j.neuron.2010.11.001  0.826
2010 Robbins EM, Krupp AJ, Perez de Arce K, Ghosh AK, Fogel AI, Boucard A, Südhof TC, Stein V, Biederer T. SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron. 68: 894-906. PMID 21145003 DOI: 10.1016/J.Neuron.2010.11.003  0.842
2010 Gustavsson N, Wang X, Wang Y, Seah T, Xu J, Radda GK, Südhof TC, Han W. Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion. Plos One. 5: e15414. PMID 21085706 DOI: 10.1371/Journal.Pone.0015414  0.736
2010 Segovia M, Alés E, Montes MA, Bonifas I, Jemal I, Lindau M, Maximov A, Südhof TC, Alvarez de Toledo G. Push-and-pull regulation of the fusion pore by synaptotagmin-7. Proceedings of the National Academy of Sciences of the United States of America. 107: 19032-7. PMID 20956309 DOI: 10.1073/Pnas.1014070107  0.797
2010 Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Südhof TC, Zheng H. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proceedings of the National Academy of Sciences of the United States of America. 107: 17362-7. PMID 20855613 DOI: 10.1073/Pnas.1012568107  0.584
2010 Zhang D, Zhang C, Ho A, Kirkwood A, Südhof TC, Shen J. Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction. Journal of Neurochemistry. 115: 1215-21. PMID 20854432 DOI: 10.1111/J.1471-4159.2010.07011.X  0.665
2010 Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Südhof TC, Rosenmund C, Rizo J. Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. Plos One. 5. PMID 20824061 DOI: 10.1371/Journal.Pone.0012544  0.734
2010 Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC. Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science (New York, N.Y.). 329: 1663-7. PMID 20798282 DOI: 10.1126/Science.1195227  0.79
2010 Pang ZP, Xu W, Cao P, Südhof TC. Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons. The Journal of Biological Chemistry. 285: 33930-9. PMID 20729199 DOI: 10.1074/jbc.M110.150151  0.733
2010 Schonn JS, van Weering JR, Mohrmann R, Schlüter OM, Südhof TC, de Wit H, Verhage M, Sørensen JB. Rab3 proteins involved in vesicle biogenesis and priming in embryonic mouse chromaffin cells. Traffic (Copenhagen, Denmark). 11: 1415-28. PMID 20716109 DOI: 10.1111/J.1600-0854.2010.01107.X  0.635
2010 Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. The Journal of Biological Chemistry. 285: 30598-605. PMID 20693289 DOI: 10.1074/Jbc.M110.137729  0.553
2010 Pang ZP, Südhof TC. Cell biology of Ca2+-triggered exocytosis. Current Opinion in Cell Biology. 22: 496-505. PMID 20561775 DOI: 10.1016/j.ceb.2010.05.001  0.608
2010 Zhang C, Atasoy D, Araç D, Yang X, Fucillo MV, Robison AJ, Ko J, Brunger AT, Südhof TC. Neurexins physically and functionally interact with GABA(A) receptors. Neuron. 66: 403-16. PMID 20471353 DOI: 10.1016/J.Neuron.2010.04.008  0.85
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.471
2010 Mukherjee K, Sharma M, Jahn R, Wahl MC, Südhof TC. Evolution of CASK into a Mg2+-sensitive kinase. Science Signaling. 3: ra33. PMID 20424264 DOI: 10.1126/Scisignal.2000800  0.431
2010 Blundell J, Kaeser PS, Südhof TC, Powell CM. RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5326-33. PMID 20392954 DOI: 10.1523/JNEUROSCI.0328-10.2010  0.743
2010 Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC. Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6504-9. PMID 20332206 DOI: 10.1073/Pnas.1002307107  0.688
2010 Pang ZP, Cao P, Xu W, Südhof TC. Calmodulin controls synaptic strength via presynaptic activation of calmodulin kinase II. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4132-42. PMID 20237283 DOI: 10.1523/JNEUROSCI.3129-09.2010  0.757
2010 Shin OH, Lu J, Rhee JS, Tomchick DR, Pang ZP, Wojcik SM, Camacho-Perez M, Brose N, Machius M, Rizo J, Rosenmund C, Südhof TC. Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nature Structural & Molecular Biology. 17: 280-8. PMID 20154707 DOI: 10.1038/Nsmb.1758  0.836
2010 Blundell J, Blaiss CA, Etherton MR, Espinosa F, Tabuchi K, Walz C, Bolliger MF, Südhof TC, Powell CM. Neuroligin-1 deletion results in impaired spatial memory and increased repetitive behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2115-29. PMID 20147539 DOI: 10.1523/Jneurosci.4517-09.2010  0.648
2010 Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 463: 1035-41. PMID 20107439 DOI: 10.1038/Nature08797  0.569
2010 Morris SJ, Südhof TC, Haynes DH. Lipid and protein interactions in ca-promoted aggregation and fusion of chromaffin granule membranes. Biophysical Journal. 37: 117-8. PMID 19431433 DOI: 10.1016/S0006-3495(82)84629-8  0.309
2009 Gogolla N, Leblanc JJ, Quast KB, Südhof TC, Fagiolini M, Hensch TK. Common circuit defect of excitatory-inhibitory balance in mouse models of autism. Journal of Neurodevelopmental Disorders. 1: 172-81. PMID 20664807 DOI: 10.1007/S11689-009-9023-X  0.349
2009 Ko J, Fuccillo MV, Malenka RC, Südhof TC. LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation. Neuron. 64: 791-8. PMID 20064387 DOI: 10.1016/J.Neuron.2009.12.012  0.844
2009 Gibson JR, Huber KM, Südhof TC. Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13883-97. PMID 19889999 DOI: 10.1523/JNEUROSCI.2457-09.2009  0.547
2009 Kaeser PS, Deng L, Chávez AE, Liu X, Castillo PE, Südhof TC. ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. Neuron. 64: 227-39. PMID 19874790 DOI: 10.1016/J.Neuron.2009.09.019  0.759
2009 Etherton MR, Blaiss CA, Powell CM, Südhof TC. Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proceedings of the National Academy of Sciences of the United States of America. 106: 17998-8003. PMID 19822762 DOI: 10.1073/pnas.0910297106  0.622
2009 Shin OH, Xu J, Rizo J, Südhof TC. Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America. 106: 16469-74. PMID 19805322 DOI: 10.1073/Pnas.0908798106  0.416
2009 Ko J, Zhang C, Arac D, Boucard AA, Brunger AT, Südhof TC. Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. The Embo Journal. 28: 3244-55. PMID 19730411 DOI: 10.1038/emboj.2009.249  0.783
2009 Zhang C, Milunsky JM, Newton S, Ko J, Zhao G, Maher TA, Tager-Flusberg H, Bolliger MF, Carter AS, Boucard AA, Powell CM, Südhof TC. A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10843-54. PMID 19726642 DOI: 10.1523/Jneurosci.1248-09.2009  0.76
2009 Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J. Presenilins are essential for regulating neurotransmitter release. Nature. 460: 632-6. PMID 19641596 DOI: 10.1038/Nature08177  0.508
2009 Deák F, Liu X, Khvotchev M, Li G, Kavalali ET, Sugita S, Südhof TC. Alpha-latrotoxin stimulates a novel pathway of Ca2+-dependent synaptic exocytosis independent of the classical synaptic fusion machinery. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8639-48. PMID 19587270 DOI: 10.1523/Jneurosci.0898-09.2009  0.78
2009 Tabuchi K, Chen G, Südhof TC, Shen J. Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7290-301. PMID 19494151 DOI: 10.1523/Jneurosci.1320-09.2009  0.346
2009 Xu J, Pang ZP, Shin OH, Südhof TC. Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release. Nature Neuroscience. 12: 759-66. PMID 19412166 DOI: 10.1038/Nn.2320  0.615
2009 Deák F, Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J. Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming. The Journal of Cell Biology. 184: 751-64. PMID 19255244 DOI: 10.1083/jcb.200812026  0.516
2009 Chang WP, Südhof TC. SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 883-97. PMID 19176798 DOI: 10.1523/JNEUROSCI.4521-08.2009  0.553
2009 Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Südhof TC, Han W. Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. The Journal of Physiology. 587: 1169-78. PMID 19171650 DOI: 10.1113/Jphysiol.2008.168005  0.711
2009 Maximov A, Tang J, Yang X, Pang ZP, Südhof TC. Complexin controls the force transfer from SNARE complexes to membranes in fusion. Science (New York, N.Y.). 323: 516-21. PMID 19164751 DOI: 10.1126/science.1166505  0.738
2009 Südhof TC, Rothman JE. Membrane fusion: grappling with SNARE and SM proteins. Science (New York, N.Y.). 323: 474-7. PMID 19164740 DOI: 10.1126/science.1161748  0.426
2009 Blundell J, Tabuchi K, Bolliger MF, Blaiss CA, Brose N, Liu X, Südhof TC, Powell CM. Increased anxiety-like behavior in mice lacking the inhibitory synapse cell adhesion molecule neuroligin 2. Genes, Brain, and Behavior. 8: 114-26. PMID 19016888 DOI: 10.1111/J.1601-183X.2008.00455.X  0.771
2009 LU J, GUSTAVSSON N, LI Q, RADDA GK, SÜDHOF TC, HAN W. GENERATION OF TRANSGENIC MICE FOR IN VIVO DETECTION OF INSULIN-CONTAINING GRANULE EXOCYTOSIS AND QUANTIFICATION OF INSULIN SECRETION Journal of Innovative Optical Health Sciences. 2: 397-405. DOI: 10.1142/S1793545809000711  0.616
2008 Ho A, Liu X, Südhof TC. Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14392-400. PMID 19118172 DOI: 10.1523/Jneurosci.2481-08.2008  0.507
2008 Kaeser PS, Kwon HB, Chiu CQ, Deng L, Castillo PE, Südhof TC. RIM1alpha and RIM1beta are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13435-47. PMID 19074017 DOI: 10.1523/JNEUROSCI.3235-08.2008  0.774
2008 Südhof TC, Malenka RC. Understanding synapses: past, present, and future. Neuron. 60: 469-76. PMID 18995821 DOI: 10.1016/j.neuron.2008.10.011  0.638
2008 Südhof TC. Neuroligins and neurexins link synaptic function to cognitive disease. Nature. 455: 903-11. PMID 18923512 DOI: 10.1038/nature07456  0.508
2008 Kaeser PS, Kwon HB, Blundell J, Chevaleyre V, Morishita W, Malenka RC, Powell CM, Castillo PE, Südhof TC. RIM1alpha phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning. Proceedings of the National Academy of Sciences of the United States of America. 105: 14680-5. PMID 18799741 DOI: 10.1073/pnas.0806679105  0.829
2008 Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC. Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science (New York, N.Y.). 321: 1507-10. PMID 18703708 DOI: 10.1126/Science.1163174  0.823
2008 Bolliger MF, Pei J, Maxeiner S, Boucard AA, Grishin NV, Südhof TC. Unusually rapid evolution of Neuroligin-4 in mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 6421-6. PMID 18434543 DOI: 10.1073/Pnas.0801383105  0.646
2008 Mukherjee K, Sharma M, Urlaub H, Bourenkov GP, Jahn R, Südhof TC, Wahl MC. CASK Functions as a Mg2+-independent neurexin kinase. Cell. 133: 328-39. PMID 18423203 DOI: 10.1016/J.Cell.2008.02.036  0.48
2008 Gustavsson N, Lao Y, Maximov A, Chuang JC, Kostromina E, Repa JJ, Li C, Radda GK, Südhof TC, Han W. Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 3992-7. PMID 18308938 DOI: 10.1073/Pnas.0711700105  0.736
2008 Maximov A, Lao Y, Li H, Chen X, Rizo J, Sørensen JB, Südhof TC. Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis. Proceedings of the National Academy of Sciences of the United States of America. 105: 3986-91. PMID 18308933 DOI: 10.1073/Pnas.0712372105  0.719
2008 Schonn JS, Maximov A, Lao Y, Südhof TC, Sørensen JB. Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 3998-4003. PMID 18308932 DOI: 10.1073/pnas.0712373105  0.67
2007 Araç D, Boucard AA, Ozkan E, Strop P, Newell E, Südhof TC, Brunger AT. Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions. Neuron. 56: 992-1003. PMID 18093522 DOI: 10.1016/j.neuron.2007.12.002  0.594
2007 Sun J, Pang ZP, Qin D, Fahim AT, Adachi R, Südhof TC. A dual-Ca2+-sensor model for neurotransmitter release in a central synapse. Nature. 450: 676-82. PMID 18046404 DOI: 10.1038/nature06308  0.581
2007 Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC. Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12147-55. PMID 17989281 DOI: 10.1523/Jneurosci.3655-07.2007  0.393
2007 Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC. A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science (New York, N.Y.). 318: 71-6. PMID 17823315 DOI: 10.1126/Science.1146221  0.658
2007 Südhof TC. Membrane fusion as a team effort. Proceedings of the National Academy of Sciences of the United States of America. 104: 13541-2. PMID 17699625 DOI: 10.1073/pnas.0706168104  0.363
2007 Wu H, Xu J, Pang ZP, Ge W, Kim KJ, Blanchi B, Chen C, Südhof TC, Sun YE. Integrative genomic and functional analyses reveal neuronal subtype differentiation bias in human embryonic stem cell lines. Proceedings of the National Academy of Sciences of the United States of America. 104: 13821-6. PMID 17693548 DOI: 10.1073/Pnas.0706199104  0.606
2007 Guan R, Dai H, Tomchick DR, Dulubova I, Machius M, Südhof TC, Rizo J. Crystal structure of the RIM1alpha C2B domain at 1.7 A resolution. Biochemistry. 46: 8988-98. PMID 17630786 DOI: 10.1021/Bi700698A  0.323
2007 Chubykin AA, Atasoy D, Etherton MR, Brose N, Kavalali ET, Gibson JR, Südhof TC. Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. Neuron. 54: 919-31. PMID 17582332 DOI: 10.1016/J.Neuron.2007.05.029  0.857
2007 Bronk P, Deák F, Wilson MC, Liu X, Südhof TC, Kavalali ET. Differential effects of SNAP-25 deletion on Ca2+ -dependent and Ca2+ -independent neurotransmission. Journal of Neurophysiology. 98: 794-806. PMID 17553942 DOI: 10.1152/Jn.00226.2007  0.778
2007 Chevaleyre V, Heifets BD, Kaeser PS, Südhof TC, Purpura DP, Castillo PE. Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha. Neuron. 54: 801-12. PMID 17553427 DOI: 10.1016/j.neuron.2007.05.020  0.687
2007 Xu J, Mashimo T, Südhof TC. Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Neuron. 54: 567-81. PMID 17521570 DOI: 10.1016/J.Neuron.2007.05.004  0.497
2007 Min SW, Chang WP, Südhof TC. E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains. Proceedings of the National Academy of Sciences of the United States of America. 104: 3823-8. PMID 17360437 DOI: 10.1073/pnas.0611725104  0.315
2007 Dudanova I, Tabuchi K, Rohlmann A, Südhof TC, Missler M. Deletion of alpha-neurexins does not cause a major impairment of axonal pathfinding or synapse formation. The Journal of Comparative Neurology. 502: 261-74. PMID 17347997 DOI: 10.1002/Cne.21305  0.723
2007 Dulubova I, Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J. Munc18-1 binds directly to the neuronal SNARE complex. Proceedings of the National Academy of Sciences of the United States of America. 104: 2697-702. PMID 17301226 DOI: 10.1073/pnas.0611318104  0.413
2007 Atasoy D, Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, Südhof TC. Deletion of CASK in mice is lethal and impairs synaptic function. Proceedings of the National Academy of Sciences of the United States of America. 104: 2525-30. PMID 17287346 DOI: 10.1073/Pnas.0611003104  0.851
2007 Nicol X, Voyatzis S, Muzerelle A, Narboux-Nême N, Südhof TC, Miles R, Gaspar P. cAMP oscillations and retinal activity are permissive for ephrin signaling during the establishment of the retinotopic map. Nature Neuroscience. 10: 340-7. PMID 17259982 DOI: 10.1038/Nn1842  0.301
2007 Maximov A, Shin OH, Liu X, Südhof TC. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release. The Journal of Cell Biology. 176: 113-24. PMID 17190793 DOI: 10.1083/jcb.200607021  0.743
2007 Maximov A, Pang ZP, Tervo DG, Südhof TC. Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. Journal of Neuroscience Methods. 161: 75-87. PMID 17118459 DOI: 10.1016/j.jneumeth.2006.10.009  0.792
2007 Chevaleyre V, Heifets BD, Kaeser PS, Südhof TC, Castillo PE. Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α (DOI:10.1016/j.neuron.2007.05.020) Neuron. 55: 169. DOI: 10.1016/j.neuron.2007.06.024  0.674
2006 Pang ZP, Melicoff E, Padgett D, Liu Y, Teich AF, Dickey BF, Lin W, Adachi R, Südhof TC. Synaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13493-504. PMID 17192432 DOI: 10.1523/Jneurosci.3519-06.2006  0.68
2006 Ho A, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC. Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13089-101. PMID 17167098 DOI: 10.1523/Jneurosci.2855-06.2006  0.836
2006 Juranek J, Mukherjee K, Rickmann M, Martens H, Calka J, Südhof TC, Jahn R. Differential expression of active zone proteins in neuromuscular junctions suggests functional diversification. The European Journal of Neuroscience. 24: 3043-52. PMID 17156365 DOI: 10.1111/j.1460-9568.2006.05183.x  0.63
2006 Pang ZP, Shin OH, Meyer AC, Rosenmund C, Südhof TC. A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12556-65. PMID 17135417 DOI: 10.1523/JNEUROSCI.3804-06.2006  0.781
2006 Schoch S, Mittelstaedt T, Kaeser PS, Padgett D, Feldmann N, Chevaleyre V, Castillo PE, Hammer RE, Han W, Schmitz F, Lin W, Südhof TC. Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. The Embo Journal. 25: 5852-63. PMID 17124501 DOI: 10.1038/Sj.Emboj.7601425  0.829
2006 Südhof TC. Synaptic vesicles: an organelle comes of age. Cell. 127: 671-3. PMID 17110326 DOI: 10.1016/j.cell.2006.10.033  0.513
2006 Tang J, Maximov A, Shin OH, Dai H, Rizo J, Südhof TC. A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell. 126: 1175-87. PMID 16990140 DOI: 10.1016/J.Cell.2006.08.030  0.692
2006 Varoqueaux F, Aramuni G, Rawson RL, Mohrmann R, Missler M, Gottmann K, Zhang W, Südhof TC, Brose N. Neuroligins determine synapse maturation and function. Neuron. 51: 741-54. PMID 16982420 DOI: 10.1016/J.Neuron.2006.09.003  0.8
2006 Deák F, Shin OH, Kavalali ET, Südhof TC. Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6668-76. PMID 16793874 DOI: 10.1523/Jneurosci.5272-05.2006  0.801
2006 Sheckler LR, Henry L, Sugita S, Südhof TC, Rudenko G. Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing. The Journal of Biological Chemistry. 281: 22896-905. PMID 16772286 DOI: 10.1074/jbc.M603464200  0.421
2006 Deák F, Shin OH, Tang J, Hanson P, Ubach J, Jahn R, Rizo J, Kavalali ET, Südhof TC. Rabphilin regulates SNARE-dependent re-priming of synaptic vesicles for fusion. The Embo Journal. 25: 2856-66. PMID 16763567 DOI: 10.1038/Sj.Emboj.7601165  0.822
2006 Lu J, Machius M, Dulubova I, Dai H, Südhof TC, Tomchick DR, Rizo J. Structural basis for a Munc13-1 homodimer to Munc13-1/RIM heterodimer switch. Plos Biology. 4: e192. PMID 16732694 DOI: 10.1371/Journal.Pbio.0040192  0.347
2006 Pang ZP, Sun J, Rizo J, Maximov A, Südhof TC. Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release. The Embo Journal. 25: 2039-50. PMID 16642042 DOI: 10.1038/sj.emboj.7601103  0.774
2006 Araç D, Chen X, Khant HA, Ubach J, Ludtke SJ, Kikkawa M, Johnson AE, Chiu W, Südhof TC, Rizo J. Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nature Structural & Molecular Biology. 13: 209-17. PMID 16491093 DOI: 10.1038/Nsmb1056  0.384
2006 Sun J, Bronk P, Liu X, Han W, Südhof TC. Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 2880-5. PMID 16481620 DOI: 10.1073/Pnas.0511300103  0.719
2006 Schmitz F, Tabares L, Khimich D, Strenzke N, de la Villa-Polo P, Castellano-Muñoz M, Bulankina A, Moser T, Fernández-Chacón R, Südhof TC. CSPalpha-deficiency causes massive and rapid photoreceptor degeneration. Proceedings of the National Academy of Sciences of the United States of America. 103: 2926-31. PMID 16477021 DOI: 10.1073/Pnas.0510060103  0.849
2006 Schlüter OM, Basu J, Südhof TC, Rosenmund C. Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1239-46. PMID 16436611 DOI: 10.1523/JNEUROSCI.3553-05.2006  0.804
2006 Nagy G, Kim JH, Pang ZP, Matti U, Rettig J, Südhof TC, Sørensen JB. Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 632-43. PMID 16407561 DOI: 10.1523/JNEUROSCI.2589-05.2006  0.608
2005 Maximov A, Südhof TC. Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release. Neuron. 48: 547-54. PMID 16301172 DOI: 10.1016/j.neuron.2005.09.006  0.646
2005 Chandra S, Gallardo G, Fernández-Chacón R, Schlüter OM, Südhof TC. Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell. 123: 383-96. PMID 16269331 DOI: 10.1016/j.cell.2005.09.028  0.758
2005 Boucard AA, Chubykin AA, Comoletti D, Taylor P, Südhof TC. A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron. 48: 229-36. PMID 16242404 DOI: 10.1016/J.Neuron.2005.08.026  0.655
2005 Dai H, Tomchick DR, García J, Südhof TC, Machius M, Rizo J. Crystal structure of the RIM2 C2A-domain at 1.4 A resolution. Biochemistry. 44: 13533-42. PMID 16216076 DOI: 10.1021/Bi0513608  0.357
2005 Shah S, Lee SF, Tabuchi K, Hao YH, Yu C, LaPlant Q, Ball H, Dann CE, Südhof T, Yu G. Nicastrin functions as a gamma-secretase-substrate receptor. Cell. 122: 435-47. PMID 16096062 DOI: 10.1016/J.Cell.2005.05.022  0.324
2005 Lu J, Li H, Wang Y, Südhof TC, Rizo J. Solution structure of the RIM1alpha PDZ domain in complex with an ELKS1b C-terminal peptide. Journal of Molecular Biology. 352: 455-66. PMID 16095618 DOI: 10.1016/J.Jmb.2005.07.047  0.449
2005 Dulubova I, Lou X, Lu J, Huryeva I, Alam A, Schneggenburger R, Südhof TC, Rizo J. A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? The Embo Journal. 24: 2839-50. PMID 16052212 DOI: 10.1038/Sj.Emboj.7600753  0.444
2005 Huang YY, Zakharenko SS, Schoch S, Kaeser PS, Janz R, Südhof TC, Siegelbaum SA, Kandel ER. Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9365-70. PMID 15967982 DOI: 10.1073/pnas.0503777102  0.755
2005 Toonen RF, de Vries KJ, Zalm R, Südhof TC, Verhage M. Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. Journal of Neurochemistry. 93: 1393-400. PMID 15935055 DOI: 10.1111/J.1471-4159.2005.03128.X  0.639
2005 Borisovska M, Zhao Y, Tsytsyura Y, Glyvuk N, Takamori S, Matti U, Rettig J, Südhof T, Bruns D. v-SNAREs control exocytosis of vesicles from priming to fusion. The Embo Journal. 24: 2114-26. PMID 15920476 DOI: 10.1038/sj.emboj.7600696  0.429
2005 Zhang W, Rohlmann A, Sargsyan V, Aramuni G, Hammer RE, Südhof TC, Missler M. Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4330-42. PMID 15858059 DOI: 10.1523/Jneurosci.0497-05.2005  0.686
2005 Südhof TC. CAPS in search of a lost function. Neuron. 46: 2-4. PMID 15820687 DOI: 10.1016/j.neuron.2005.03.017  0.316
2005 Chubykin AA, Liu X, Comoletti D, Tsigelny I, Taylor P, Südhof TC. Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. The Journal of Biological Chemistry. 280: 22365-74. PMID 15797875 DOI: 10.1074/Jbc.M410723200  0.711
2005 Chen X, Tang J, Sudhof TC, Rizo J. Are neuronal SNARE proteins Ca2+ sensors? Journal of Molecular Biology. 347: 145-58. PMID 15733924 DOI: 10.1016/j.jmb.2005.01.024  0.364
2005 Sara Y, Biederer T, Atasoy D, Chubykin A, Mozhayeva MG, Südhof TC, Kavalali ET. Selective capability of SynCAM and neuroligin for functional synapse assembly. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 260-70. PMID 15634790 DOI: 10.1523/Jneurosci.3165-04.2005  0.856
2005 Han W, Rhee JS, Maximov A, Lin W, Hammer RE, Rosenmund C, Südhof TC. C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1. The Journal of Biological Chemistry. 280: 5089-100. PMID 15561725 DOI: 10.1074/Jbc.M408757200  0.854
2005 Shin OH, Han W, Wang Y, Südhof TC. Evolutionarily conserved multiple C2 domain proteins with two transmembrane regions (MCTPs) and unusual Ca2+ binding properties. The Journal of Biological Chemistry. 280: 1641-51. PMID 15528213 DOI: 10.1074/Jbc.M407305200  0.644
2004 Khvotchev MV, Südhof TC. Stimulus-dependent dynamic homo- and heteromultimerization of synaptobrevin/VAMP and synaptophysin. Biochemistry. 43: 15037-43. PMID 15554711 DOI: 10.1021/bi048290+  0.488
2004 Deák F, Schoch S, Liu X, Südhof TC, Kavalali ET. Synaptobrevin is essential for fast synaptic-vesicle endocytosis. Nature Cell Biology. 6: 1102-8. PMID 15475946 DOI: 10.1038/Ncb1185  0.792
2004 Chandra S, Fornai F, Kwon HB, Yazdani U, Atasoy D, Liu X, Hammer RE, Battaglia G, German DC, Castillo PE, Südhof TC. Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proceedings of the National Academy of Sciences of the United States of America. 101: 14966-71. PMID 15465911 DOI: 10.1073/Pnas.0406283101  0.714
2004 Khvotchev M, Südhof TC. Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport. The Journal of Biological Chemistry. 279: 47101-8. PMID 15316009 DOI: 10.1074/jbc.M408474200  0.309
2004 Dai H, Shin OH, Machius M, Tomchick DR, Südhof TC, Rizo J. Structural basis for the evolutionary inactivation of Ca2+ binding to synaptotagmin 4. Nature Structural & Molecular Biology. 11: 844-9. PMID 15311271 DOI: 10.1038/Nsmb817  0.342
2004 Dulubova I, Ho A, Huryeva I, Südhof TC, Rizo J. Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. Biochemistry. 43: 9583-8. PMID 15274612 DOI: 10.1021/Bi049041O  0.508
2004 Schlüter OM, Schmitz F, Jahn R, Rosenmund C, Südhof TC. A complete genetic analysis of neuronal Rab3 function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6629-37. PMID 15269275 DOI: 10.1523/JNEUROSCI.1610-04.2004  0.808
2004 Sudhof TC. The synaptic vesicle cycle. Annual Review of Neuroscience. 27: 509-47. PMID 15217342 DOI: 10.1146/annurev.neuro.26.041002.131412  0.499
2004 Calakos N, Schoch S, Südhof TC, Malenka RC. Multiple roles for the active zone protein RIM1alpha in late stages of neurotransmitter release. Neuron. 42: 889-96. PMID 15207234 DOI: 10.1016/j.neuron.2004.05.014  0.7
2004 Fernández-Chacón R, Wölfel M, Nishimune H, Tabares L, Schmitz F, Castellano-Muñoz M, Rosenmund C, Montesinos ML, Sanes JR, Schneggenburger R, Südhof TC. The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron. 42: 237-51. PMID 15091340 DOI: 10.1016/S0896-6273(04)00190-4  0.857
2004 Powell CM, Schoch S, Monteggia L, Barrot M, Matos MF, Feldmann N, Südhof TC, Nestler EJ. The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron. 42: 143-53. PMID 15066271 DOI: 10.1016/S0896-6273(04)00146-1  0.688
2004 Kattenstroth G, Tantalaki E, Südhof TC, Gottmann K, Missler M. Postsynaptic N-methyl-D-aspartate receptor function requires alpha-neurexins. Proceedings of the National Academy of Sciences of the United States of America. 101: 2607-12. PMID 14983056 DOI: 10.1073/Pnas.0308626100  0.674
2004 Shin OH, Maximov A, Lim BK, Rizo J, Südhof TC. Unexpected Ca2+-binding properties of synaptotagmin 9. Proceedings of the National Academy of Sciences of the United States of America. 101: 2554-9. PMID 14983047 DOI: 10.1073/Pnas.0308477100  0.643
2004 Ho A, Südhof TC. Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proceedings of the National Academy of Sciences of the United States of America. 101: 2548-53. PMID 14983046 DOI: 10.1073/Pnas.0308655100  0.522
2004 Garcia J, Gerber SH, Sugita S, Südhof TC, Rizo J. A conformational switch in the Piccolo C2A domain regulated by alternative splicing. Nature Structural & Molecular Biology. 11: 45-53. PMID 14718922 DOI: 10.1038/nsmb707  0.328
2004 Han W, Rhee JS, Maximov A, Lao Y, Mashimo T, Rosenmund C, Südhof TC. N-glycosylation is essential for vesicular targeting of synaptotagmin 1. Neuron. 41: 85-99. PMID 14715137 DOI: 10.1016/S0896-6273(03)00820-1  0.824
2004 Li Q, Südhof TC. Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. The Journal of Biological Chemistry. 279: 10542-50. PMID 14699153 DOI: 10.1074/jbc.M310001200  0.304
2004 Dulubova I, Ho A, Huryeva I, Südhof TC, Rizo J. P1-183 Three-dimensional structure of an autonomously folded domain of human amyloid-β precursor protein Neurobiology of Aging. 25: S148. DOI: 10.1016/S0197-4580(04)80496-2  0.48
2003 Khvotchev MV, Ren M, Takamori S, Jahn R, Südhof TC. Divergent functions of neuronal Rab11b in Ca2+-regulated versus constitutive exocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10531-9. PMID 14627637 DOI: 10.1523/Jneurosci.23-33-10531.2003  0.606
2003 Virmani T, Han W, Liu X, Südhof TC, Kavalali ET. Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. The Embo Journal. 22: 5347-57. PMID 14532108 DOI: 10.1093/Emboj/Cdg514  0.849
2003 Lonart G, Schoch S, Kaeser PS, Larkin CJ, Südhof TC, Linden DJ. Phosphorylation of RIM1alpha by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses. Cell. 115: 49-60. PMID 14532002 DOI: 10.1016/S0092-8674(03)00727-X  0.742
2003 Matos MF, Mukherjee K, Chen X, Rizo J, Südhof TC. Evidence for SNARE zippering during Ca2+-triggered exocytosis in PC12 cells. Neuropharmacology. 45: 777-86. PMID 14529716 DOI: 10.1016/S0028-3908(03)00318-6  0.455
2003 Comoletti D, Flynn R, Jennings LL, Chubykin A, Matsumura T, Hasegawa H, Südhof TC, Taylor P. Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. The Journal of Biological Chemistry. 278: 50497-505. PMID 14522992 DOI: 10.1074/jbc.M306803200  0.595
2003 Sørensen JB, Fernández-Chacón R, Südhof TC, Neher E. Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+. The Journal of General Physiology. 122: 265-76. PMID 12939392 DOI: 10.1085/jgp.200308855  0.77
2003 Missler M, Zhang W, Rohlmann A, Kattenstroth G, Hammer RE, Gottmann K, Südhof TC. Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature. 423: 939-48. PMID 12827191 DOI: 10.1038/Nature01755  0.737
2003 Wang Y, Südhof TC. Genomic definition of RIM proteins: evolutionary amplification of a family of synaptic regulatory proteins. Genomics. 81: 126-37. PMID 12620390 DOI: 10.1016/S0888-7543(02)00024-1  0.365
2003 Jahn R, Lang T, Südhof TC. Membrane fusion. Cell. 112: 519-33. PMID 12600315  0.388
2003 Chandra S, Chen X, Rizo J, Jahn R, Südhof TC. A broken alpha -helix in folded alpha -Synuclein. The Journal of Biological Chemistry. 278: 15313-8. PMID 12586824 DOI: 10.1074/jbc.M213128200  0.431
2003 Ho A, Morishita W, Hammer RE, Malenka RC, Sudhof TC. A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 100: 1409-14. PMID 12547917 DOI: 10.1073/Pnas.252774899  0.863
2003 Shin OH, Rhee JS, Tang J, Sugita S, Rosenmund C, Südhof TC. Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Neuron. 37: 99-108. PMID 12526776 DOI: 10.1016/S0896-6273(02)01145-5  0.719
2003 Dulubova I, Yamaguchi T, Arac D, Li H, Huryeva I, Min SW, Rizo J, Sudhof TC. Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins. Proceedings of the National Academy of Sciences of the United States of America. 100: 32-7. PMID 12506202 DOI: 10.1073/Pnas.232701299  0.465
2003 Chandra S, Chen X, Rizo J, Jahn R, Sudhof T. Backbone Assignments of folded alpha-synuclein Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5744  0.578
2003 Liu X, Han W, Biederer T, Kavalali E, Südhof T. Identification of endogenous/transfected synaptic proteins in primary neuronal culture by a high-yield immunogold labeling Microscopy and Microanalysis. 9: 1498-1499. DOI: 10.1017/S1431927603447491  0.825
2003 Liu X, Han W, Biederer T, Kavalali E, Südhof T. Identification of Endogenous/transfected Synaptic Proteins in Primary Neuronal Culture by a High-yield Immunogold Labeling Microscopy and Microanalysis. 9: 1498-1499. DOI: 10.1017/s1431927603447491  0.809
2003 Lonart G, Schoch S, Kaeser PS, Larkin CJ, Südhof TC, Linden DJ. Phosphorylation of RIM1α by PKA triggers presynaptic long-term potentiation at cerebellar parallel fiber synapses Cell. 115: 49-60. DOI: 10.1016/S0092-8674(03)00727-X  0.656
2002 Wang Y, Liu X, Biederer T, Südhof TC. A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones. Proceedings of the National Academy of Sciences of the United States of America. 99: 14464-9. PMID 12391317 DOI: 10.1073/pnas.182532999  0.694
2002 Fernández-Chacón R, Shin OH, Königstorfer A, Matos MF, Meyer AC, Garcia J, Gerber SH, Rizo J, Südhof TC, Rosenmund C. Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8438-46. PMID 12351718 DOI: 10.1523/Jneurosci.22-19-08438.2002  0.817
2002 Biederer T, Sara Y, Mozhayeva M, Atasoy D, Liu X, Kavalali ET, Südhof TC. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science (New York, N.Y.). 297: 1525-31. PMID 12202822 DOI: 10.1126/Science.1072356  0.863
2002 Biederer T, Cao X, Südhof TC, Liu X. Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7340-51. PMID 12196555 DOI: 10.1523/Jneurosci.22-17-07340.2002  0.687
2002 Riedel D, Antonin W, Fernandez-Chacon R, Alvarez de Toledo G, Jo T, Geppert M, Valentijn JA, Valentijn K, Jamieson JD, Südhof TC, Jahn R. Rab3D is not required for exocrine exocytosis but for maintenance of normally sized secretory granules. Molecular and Cellular Biology. 22: 6487-97. PMID 12192047 DOI: 10.1128/Mcb.22.18.6487-6497.2002  0.804
2002 Schlüter OM, Khvotchev M, Jahn R, Südhof TC. Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion. The Journal of Biological Chemistry. 277: 40919-29. PMID 12167638 DOI: 10.1074/jbc.M203704200  0.595
2002 Rizo J, Südhof TC. Snares and Munc18 in synaptic vesicle fusion. Nature Reviews. Neuroscience. 3: 641-53. PMID 12154365 DOI: 10.1038/nrn898  0.485
2002 Dulubova I, Yamaguchi T, Gao Y, Min SW, Huryeva I, Südhof TC, Rizo J. How Tlg2p/syntaxin 16 'snares' Vps45. The Embo Journal. 21: 3620-31. PMID 12110575 DOI: 10.1093/emboj/cdf381  0.338
2002 Shin OH, Rizo J, Südhof TC. Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells. Nature Neuroscience. 5: 649-56. PMID 12055633 DOI: 10.1038/nn869  0.397
2002 Tabuchi K, Biederer T, Butz S, Sudhof TC. CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4264-73. PMID 12040031 DOI: 10.1523/Jneurosci.22-11-04264.2002  0.664
2002 Tabuchi K, Südhof TC. Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing. Genomics. 79: 849-59. PMID 12036300 DOI: 10.1006/Geno.2002.6780  0.354
2002 Yamaguchi T, Dulubova I, Min SW, Chen X, Rizo J, Südhof TC. Sly1 binds to Golgi and ER syntaxins via a conserved N-terminal peptide motif. Developmental Cell. 2: 295-305. PMID 11879635 DOI: 10.1016/S1534-5807(02)00125-9  0.362
2002 Chen X, Tomchick DR, Kovrigin E, Araç D, Machius M, Südhof TC, Rizo J. Three-dimensional structure of the complexin/SNARE complex. Neuron. 33: 397-409. PMID 11832227 DOI: 10.1016/S0896-6273(02)00583-4  0.419
2002 Sugita S, Shin OH, Han W, Lao Y, Südhof TC. Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities. The Embo Journal. 21: 270-80. PMID 11823420 DOI: 10.1093/Emboj/21.3.270  0.654
2002 Gerber SH, Rizo J, Südhof TC. Role of electrostatic and hydrophobic interactions in Ca(2+)-dependent phospholipid binding by the C(2)A-domain from synaptotagmin I. Diabetes. 51: S12-8. PMID 11815451 DOI: 10.2337/Diabetes.51.2007.S12  0.361
2002 Gerber SH, Südhof TC. Molecular determinants of regulated exocytosis. Diabetes. 51: S3-11. PMID 11815450 DOI: 10.2337/Diabetes.51.2007.S3  0.356
2002 Castillo PE, Schoch S, Schmitz F, Südhof TC, Malenka RC. RIM1alpha is required for presynaptic long-term potentiation. Nature. 415: 327-30. PMID 11797010 DOI: 10.1038/415327a  0.668
2002 Schoch S, Castillo PE, Jo T, Mukherjee K, Geppert M, Wang Y, Schmitz F, Malenka RC, Südhof TC. RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone. Nature. 415: 321-6. PMID 11797009 DOI: 10.1038/415321a  0.676
2002 Rhee JS, Betz A, Pyott S, Reim K, Varoqueaux F, Augustin I, Hesse D, Südhof TC, Takahashi M, Rosenmund C, Brose N. Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. Cell. 108: 121-33. PMID 11792326 DOI: 10.1016/S0092-8674(01)00635-3  0.787
2001 Biederer T, Sudhof TC. CASK and protein 4.1 support F-actin nucleation on neurexins. The Journal of Biological Chemistry. 276: 47869-76. PMID 11604393 DOI: 10.1074/jbc.M105287200  0.679
2001 Voets T, Moser T, Lund PE, Chow RH, Geppert M, Südhof TC, Neher E. Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I. Proceedings of the National Academy of Sciences of the United States of America. 98: 11680-5. PMID 11562488 DOI: 10.1073/Pnas.201398798  0.459
2001 Voets T, Toonen RF, Brian EC, de Wit H, Moser T, Rettig J, Südhof TC, Neher E, Verhage M. Munc18-1 promotes large dense-core vesicle docking. Neuron. 31: 581-91. PMID 11545717 DOI: 10.1016/S0896-6273(01)00391-9  0.639
2000 von Poser C, Zhang JZ, Mineo C, Ding W, Ying Y, Sudhof TC, Anderson RG. Synaptotagmin regulation of coated pit assembly. The Journal of Biological Chemistry. 275: 30916-24. PMID 10906143 DOI: 10.1074/jbc.M005559200  0.311
2000 Wang Y, Sugita S, Sudhof TC. The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins. The Journal of Biological Chemistry. 275: 20033-44. PMID 10748113 DOI: 10.1074/jbc.M909008199  0.405
2000 Verhage M, Maia AS, Plomp JJ, Brussaard AB, Heeroma JH, Vermeer H, Toonen RF, Hammer RE, van den Berg TK, Missler M, Geuze HJ, Südhof TC. Synaptic assembly of the brain in the absence of neurotransmitter secretion. Science (New York, N.Y.). 287: 864-9. PMID 10657302 DOI: 10.1126/Science.287.5454.864  0.805
1999 Janz R, Südhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY. Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I. Neuron. 24: 687-700. PMID 10595519 DOI: 10.1016/S0896-6273(00)81122-8  0.546
1999 Schlüter OM, Schnell E, Verhage M, Tzonopoulos T, Nicoll RA, Janz R, Malenka RC, Geppert M, Südhof TC. Rabphilin knock-out mice reveal that rabphilin is not required for rab3 function in regulating neurotransmitter release. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5834-46. PMID 10407024 DOI: 10.1523/Jneurosci.19-14-05834.1999  0.772
1999 Sugita S, Janz R, Südhof TC. Synaptogyrins regulate Ca2+-dependent exocytosis in PC12 cells. The Journal of Biological Chemistry. 274: 18893-901. PMID 10383386 DOI: 10.1074/jbc.274.27.18893  0.478
1999 Okamoto M, Schoch S, Südhof TC. EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? The Journal of Biological Chemistry. 274: 18446-54. PMID 10373452 DOI: 10.1074/jbc.274.26.18446  0.322
1999 Hosaka M, Südhof TC. Homo- and heterodimerization of synapsins. The Journal of Biological Chemistry. 274: 16747-53. PMID 10358015 DOI: 10.1074/jbc.274.24.16747  0.377
1999 Stahl B, Diehlmann A, Südhof TC. Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071. The Journal of Biological Chemistry. 274: 9141-8. PMID 10092585 DOI: 10.1074/jbc.274.14.9141  0.302
1999 Okamoto M, Südhof TC. Mint 3: a ubiquitous mint isoform that does not bind to munc18-1 or -2. European Journal of Cell Biology. 77: 161-5. PMID 9860131 DOI: 10.1016/S0171-9335(98)80103-9  0.41
1999 Sugita S, Ichtchenko K, Khvotchev M, Südhof TC. alpha-Latrotoxin receptor CIRL/latrophilin 1 (CL1) defines an unusual family of ubiquitous G-protein-linked receptors. G-protein coupling not required for triggering exocytosis. The Journal of Biological Chemistry. 273: 32715-24. PMID 9830014 DOI: 10.1074/JBC.273.49.32715  0.312
1999 Zhang X, Rizo J, Südhof TC. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry. 37: 12395-403. PMID 9730811 DOI: 10.1021/BI9807512  0.344
1998 Lonart G, Janz R, Johnson KM, Südhof TC. Mechanism of action of rab3A in mossy fiber LTP Neuron. 21: 1141-1150. PMID 9856469 DOI: 10.1016/S0896-6273(00)80631-5  0.457
1998 Shao X, Fernandez I, Südhof TC, Rizo J. Solution structures of the Ca2+-free and Ca2+-bound C2A domain of synaptotagmin I: does Ca2+ induce a conformational change? Biochemistry. 37: 16106-15. PMID 9819203 DOI: 10.1021/BI981789H  0.322
1998 Tzounopoulos T, Janz R, Südhof TC, Nicoll RA, Malenka RC. A role for cAMP in long-term depression at hippocampal mossy fiber synapses. Neuron. 21: 837-45. PMID 9808469 DOI: 10.1016/S0896-6273(00)80599-1  0.607
1998 Fernandez I, Ubach J, Dulubova I, Zhang X, Südhof TC, Rizo J. Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A. Cell. 94: 841-9. PMID 9753330 DOI: 10.1016/S0092-8674(00)81742-0  0.348
1998 Butz S, Okamoto M, Südhof TC. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell. 94: 773-82. PMID 9753324 DOI: 10.1016/S0092-8674(00)81736-5  0.499
1998 Khvotchev M, Südhof TC. Newly synthesized phosphatidylinositol phosphates are required for synaptic norepinephrine but not glutamate or gamma-aminobutyric acid (GABA) release. The Journal of Biological Chemistry. 273: 21451-4. PMID 9705272 DOI: 10.1074/jbc.273.34.21451  0.42
1998 Betz A, Ashery U, Rickmann M, Augustin I, Neher E, Südhof TC, Rettig J, Brose N. Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron. 21: 123-36. PMID 9697857 DOI: 10.1016/S0896-6273(00)80520-6  0.63
1998 Hirao K, Hata Y, Ide N, Takeuchi M, Irie M, Yao I, Deguchi M, Toyoda A, Sudhof TC, Takai Y. A novel multiple PDZ domain-containing molecule interacting with N-methyl-D-aspartate receptors and neuronal cell adhesion proteins. The Journal of Biological Chemistry. 273: 21105-10. PMID 9694864 DOI: 10.1074/Jbc.273.33.21105  0.493
1998 Ubach J, Zhang X, Shao X, Südhof TC, Rizo J. Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain? The Embo Journal. 17: 3921-30. PMID 9670009 DOI: 10.1093/emboj/17.14.3921  0.327
1998 Hosaka M, Südhof TC. Synapsin III, a novel synapsin with an unusual regulation by Ca2+. The Journal of Biological Chemistry. 273: 13371-4. PMID 9593663 DOI: 10.1074/jbc.273.22.13371  0.399
1998 Geppert M, Südhof TC. RAB3 and synaptotagmin: the yin and yang of synaptic membrane fusion. Annual Review of Neuroscience. 21: 75-95. PMID 9530492 DOI: 10.1146/ANNUREV.NEURO.21.1.75  0.452
1998 Esser L, Wang CR, Hosaka M, Smagula CS, Südhof TC, Deisenhofer J. Synapsin I is structurally similar to ATP-utilizing enzymes. The Embo Journal. 17: 977-84. PMID 9463376 DOI: 10.1093/Emboj/17.4.977  0.347
1998 Janz R, Südhof TC. Cellugyrin, a novel ubiquitous form of synaptogyrin that is phosphorylated by pp60c-src. The Journal of Biological Chemistry. 273: 2851-7. PMID 9446595 DOI: 10.1074/JBC.273.5.2851  0.402
1998 Hosaka M, Südhof TC. Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation. The Journal of Biological Chemistry. 273: 1425-9. PMID 9430678 DOI: 10.1074/jbc.273.3.1425  0.415
1998 Lledo PM, Zhang X, Südhof TC, Malenka RC, Nicoll RA. Postsynaptic membrane fusion and long-term potentiation. Science (New York, N.Y.). 279: 399-403. PMID 9430593 DOI: 10.1126/science.279.5349.399  0.65
1998 Okamoto M, Südhof TC. Mints, Munc18-interacting proteins in synaptic vesicle exocytosis. The Journal of Biological Chemistry. 272: 31459-64. PMID 9395480 DOI: 10.1074/jbc.272.50.31459  0.473
1998 Janz R, Hofmann K, Südhof TC. SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles The Journal of Neuroscience. 18: 9269-9281. DOI: 10.1523/JNEUROSCI.18-22-09269.1998  0.504
1998 Lonart G, Südhof TC. Region-Specific Phosphorylation of Rabphilin in Mossy Fiber Nerve Terminals of the Hippocampus The Journal of Neuroscience. 18: 634-640. DOI: 10.1523/Jneurosci.18-02-00634.1998  0.405
1997 Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Südhof TC. Binding of neuroligins to PSD-95. Science (New York, N.Y.). 277: 1511-5. PMID 9278515 DOI: 10.1126/Science.277.5331.1511  0.399
1997 Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof TC. Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature. 388: 593-8. PMID 9252191 DOI: 10.1038/41580  0.572
1997 Castillo PE, Janz R, Südhof TC, Tzounopoulos T, Malenka RC, Nicoll RA. Rab3A is essential for mossy fibre long-term potentiation in the hippocampus. Nature. 388: 590-3. PMID 9252190 DOI: 10.1038/41574  0.68
1997 von Poser C, Ichtchenko K, Shao X, Rizo J, Südhof TC. The evolutionary pressure to inactivate. A subclass of synaptotagmins with an amino acid substitution that abolishes Ca2+ binding. The Journal of Biological Chemistry. 272: 14314-9. PMID 9162066 DOI: 10.1074/jbc.272.22.14314  0.358
1997 Shao X, Li C, Fernandez I, Zhang X, Südhof TC, Rizo J. Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch. Neuron. 18: 133-42. PMID 9010211 DOI: 10.1016/S0896-6273(01)80052-0  0.397
1997 Janz R, Südhof TC. A systematic approach to studying synaptic function in vertebrates. Cold Spring Harbor Symposia On Quantitative Biology. 60: 309-14. PMID 8824404 DOI: 10.1101/SQB.1995.060.01.035  0.467
1996 Silva AJ, Rosahl TW, Chapman PF, Marowitz Z, Friedman E, Frankland PW, Cestari V, Cioffi D, Südhof TC, Bourtchuladze R. Impaired learning in mice with abnormal short-lived plasticity. Current Biology : Cb. 6: 1509-18. PMID 8939606 DOI: 10.1016/S0960-9822(96)00756-7  0.32
1996 McMahon HT, Bolshakov VY, Janz R, Hammer RE, Siegelbaum SA, Südhof TC. Synaptophysin, a major synaptic vesicle protein, is not essential for neurotransmitter release. Proceedings of the National Academy of Sciences of the United States of America. 93: 4760-4. PMID 8643476 DOI: 10.1073/pnas.93.10.4760  0.543
1996 Ullrich B, Südhof TC. Differential distributions of novel synaptotagmins: comparison to synapsins. Neuropharmacology. 34: 1371-7. PMID 8606786 DOI: 10.1016/0028-3908(95)00132-P  0.442
1996 Ichtchenko K, Nguyen T, Südhof TC. Structures, alternative splicing, and neurexin binding of multiple neuroligins. The Journal of Biological Chemistry. 271: 2676-82. PMID 8576240 DOI: 10.1074/jbc.271.5.2676  0.368
1996 Sugita S, Hata Y, Südhof TC. Distinct Ca(2+)-dependent properties of the first and second C2-domains of synaptotagmin I. The Journal of Biological Chemistry. 271: 1262-5. PMID 8576108 DOI: 10.1074/jbc.271.3.1262  0.348
1996 Hata Y, Butz S, Sudhof T. CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins The Journal of Neuroscience. 16: 2488-2494. DOI: 10.1523/Jneurosci.16-08-02488.1996  0.391
1996 Stahl B, Chou JH, Li C, Südhof TC, Jahn R. Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras. The Embo Journal. 15: 1799-1809. DOI: 10.1002/j.1460-2075.1996.tb00529.x  0.625
1995 Spillane DM, Rosahl TW, Südhof TC, Malenka RC. Long-term potentiation in mice lacking synapsins. Neuropharmacology. 34: 1573-9. PMID 8606805 DOI: 10.1016/0028-3908(95)00107-H  0.699
1995 Ullrich B, Li C, Zhang JZ, McMahon H, Anderson RG, Geppert M, Südhof TC. Functional properties of multiple synaptotagmins in brain. Neuron. 13: 1281-91. PMID 7993622 DOI: 10.1016/0896-6273(94)90415-4  0.498
1995 Ullrich B, Südhof TC. Distribution of synaptic markers in the retina: implications for synaptic vesicle traffic in ribbon synapses. Journal of Physiology, Paris. 88: 249-57. PMID 7874086 DOI: 10.1016/0928-4257(94)90088-4  0.457
1995 McMahon HT, Südhof TC. Synaptic core complex of synaptobrevin, syntaxin, and SNAP25 forms high affinity alpha-SNAP binding site. The Journal of Biological Chemistry. 270: 2213-7. PMID 7836452 DOI: 10.1074/jbc.270.5.2213  0.353
1995 Südhof TC. The synaptic vesicle cycle: a cascade of protein-protein interactions. Nature. 375: 645-53. PMID 7791897 DOI: 10.1038/375645A0  0.503
1995 Rosahl TW, Spillane D, Missler M, Herz J, Selig DK, Wolff JR, Hammer RE, Malenka RC, Südhof TC. Essential functions of synapsins I and II in synaptic vesicle regulation. Nature. 375: 488-93. PMID 7777057 DOI: 10.1038/375488A0  0.828
1995 Hata Y, Südhof TC. A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic. The Journal of Biological Chemistry. 270: 13022-8. PMID 7768895 DOI: 10.1074/JBC.270.22.13022  0.374
1995 Wang LH, Südhof TC, Anderson RG. The appendage domain of alpha-adaptin is a high affinity binding site for dynamin. The Journal of Biological Chemistry. 270: 10079-83. PMID 7730311 DOI: 10.1074/JBC.270.17.10079  0.334
1995 Fykse EM, Li C, Sudhof TC. Phosphorylation of rabphilin-3A by Ca2+/calmodulin- and cAMP-dependent protein kinases in vitro The Journal of Neuroscience. 15: 2385-2395. DOI: 10.1523/Jneurosci.15-03-02385.1995  0.36
1994 Reizes O, Barylko B, Li C, Südhof TC, Albanesi JP. Domain structure of a mammalian myosin I beta. Proceedings of the National Academy of Sciences of the United States of America. 91: 6349-53. PMID 8022785 DOI: 10.1073/PNAS.91.14.6349  0.303
1994 Robinson PJ, Liu JP, Powell KA, Fykse EM, Südhof TC. Phosphorylation of dynamin I and synaptic-vesicle recycling Trends in Neurosciences. 17: 348-353. PMID 7526507 DOI: 10.1016/0166-2236(94)90179-1  0.517
1994 Hayashi T, McMahon H, Yamasaki S, Binz T, Hata Y, Südhof T, Niemann H. Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. The Embo Journal. 13: 5051-5061. DOI: 10.1002/J.1460-2075.1994.Tb06834.X  0.43
1993 Armstrong SA, Seabra MC, Südhof TC, Goldstein JL, Brown MS. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. The Journal of Biological Chemistry. 268: 12221-9. PMID 8505342  0.598
1993 Robinson PJ, Sontag JM, Liu JP, Fykse EM, Slaughter C, McMahon H, Südhof TC. Dynamin GTPase regulated by protein kinase C phosphorylation in nerve terminals. Nature. 365: 163-6. PMID 8371759 DOI: 10.1038/365163A0  0.372
1993 Hata Y, Slaughter CA, Südhof TC. Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin. Nature. 366: 347-51. PMID 8247129 DOI: 10.1038/366347A0  0.515
1993 Rosahl TW, Geppert M, Spillane D, Herz J, Hammer RE, Malenka RC, Südhof TC. Short-term synaptic plasticity is altered in mice lacking synapsin I. Cell. 75: 661-70. PMID 7902212 DOI: 10.1016/0092-8674(93)90487-B  0.739
1993 Fykse E, Takei K, Walch-Solimena C, Geppert M, Jahn R, Camilli PD, Sudhof T. Relative properties and localizations of synaptic vesicle protein isoforms : the case of the synaptophysins The Journal of Neuroscience. 13: 4997-5007. DOI: 10.1523/Jneurosci.13-11-04997.1993  0.582
1993 Walch-Solimena C, Takei K, Marek K, Midyett K, Sudhof T, Camilli PD, Jahn R. Synaptotagmin: a membrane constituent of neuropeptide-containing large dense-core vesicles The Journal of Neuroscience. 13: 3895-3903. DOI: 10.1523/Jneurosci.13-09-03895.1993  0.581
1993 Südhof TC, Camilll PD, Niemann H, Jahn R. Membrane fusion machinery: Insights from synaptic proteins Cell. 75: 1-4. DOI: 10.1016/S0092-8674(05)80077-7  0.454
1993 Mignery GA, Südhof TC. Molecular Analysis of Inositol 1,4,5-Trisphosphate Receptors Methods in Neurosciences. 18: 247-265. DOI: 10.1016/B978-0-12-185285-6.50028-2  0.342
1993 Mollard GFv, Südhof TC, Jahn R. Synaptic Vesicle Membrane Traffic and the Cycle of Rab3 Handbook of Experimental Pharmacology. 108: 477-485. DOI: 10.1007/978-3-642-78267-1_31  0.649
1992 Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL. Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. Cell. 70: 1049-57. PMID 1525821 DOI: 10.1016/0092-8674(92)90253-9  0.543
1992 Lin HC, Südhof TC, Anderson RG. Annexin VI is required for budding of clathrin-coated pits. Cell. 70: 283-91. PMID 1386288 DOI: 10.1016/0092-8674(92)90102-I  0.311
1992 Seabra MC, Goldstein JL, Südhof TC, Brown MS. Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys. The Journal of Biological Chemistry. 267: 14497-503. PMID 1321151  0.503
1992 Takei K, Stukenbrok H, Metcalf A, Mignery G, Sudhof T, Volpe P, Camilli PD. Ca2+ stores in Purkinje neurons: endoplasmic reticulum subcompartments demonstrated by the heterogeneous distribution of the InsP3 receptor, Ca(2+)-ATPase, and calsequestrin. The Journal of Neuroscience. 12: 489-505. DOI: 10.1523/Jneurosci.12-02-00489.1992  0.346
1991 Fischer von Mollard G, Südhof TC, Jahn R. A small GTP-binding protein dissociates from synaptic vesicles during exocytosis. Nature. 349: 79-81. PMID 1845915 DOI: 10.1038/349079A0  0.563
1991 Südhof TC, Jahn R. Proteins of synaptic vesicles involved in exocytosis and membrane recycling Neuron. 6: 665-677. PMID 1673848 DOI: 10.1016/0896-6273(91)90165-V  0.635
1990 Südhof TC. Synaptic vesicles. Current Opinion in Cell Biology. 1: 655-9. PMID 2576382 DOI: 10.1016/0955-0674(89)90030-6  0.427
1990 Südhof TC, Baumert M, Perin MS, Jahn R. A synaptic vesicle membrane protein is conserved from mammals to Drosophila. Neuron. 2: 1475-81. PMID 2560644 DOI: 10.1016/0896-6273(89)90193-1  0.588
1990 Perin MS, Fried VA, Mignery GA, Jahn R, Südhof TC. Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C Nature. 345: 260-263. PMID 2333096 DOI: 10.1038/345260A0  0.627
1990 Mignery GA, Südhof TC. The ligand binding site and transduction mechanism in the inositol-1,4,5-triphosphate receptor Embo Journal. 9: 3893-3898. PMID 2174351 DOI: 10.1002/J.1460-2075.1990.Tb07609.X  0.303
1990 Fischer von Mollard G, Mignery GA, Baumert M, Perin MS, Hanson TJ, Burger PM, Jahn R, Südhof TC. rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles. Proceedings of the National Academy of Sciences of the United States of America. 87: 1988-92. PMID 2155429 DOI: 10.1073/Pnas.87.5.1988  0.605
1988 Dawson PA, Hofmann SL, van der Westhuyzen DR, Südhof TC, Brown MS, Goldstein JL. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1. The Journal of Biological Chemistry. 263: 3372-9. PMID 3277969  0.491
1988 Südhof TC, Slaughter CA, Leznicki I, Barjon P, Reynolds GA. Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins. Proceedings of the National Academy of Sciences of the United States of America. 85: 664-8. PMID 2963335 DOI: 10.1073/PNAS.85.3.664  0.312
1988 Perin MS, Fried VA, Slaughter CA, Südhof TC. The structure of cytochrome b561, a secretory vesicle-specific electron transport protein. The Embo Journal. 7: 2697-2703. DOI: 10.1002/j.1460-2075.1988.tb03123.x  0.315
1987 Südhof TC, Van der Westhuyzen DR, Goldstein JL, Brown MS, Russell DW. Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene. The Journal of Biological Chemistry. 262: 10773-9. PMID 3611089  0.481
1987 Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region. Nature. 326: 760-5. PMID 3494949 DOI: 10.1038/326760A0  0.543
1987 van Driel IR, Goldstein JL, Südhof TC, Brown MS. First cysteine-rich repeat in ligand-binding domain of low density lipoprotein receptor binds Ca2+ and monoclonal antibodies, but not lipoproteins. The Journal of Biological Chemistry. 262: 17443-9. PMID 3320043  0.51
1987 Südhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R. A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions. Science (New York, N.Y.). 238: 1142-4. PMID 3120313 DOI: 10.1126/SCIENCE.3120313  0.589
1987 Südhof TC, Lottspeich F, Greengard P, Mehl E, Jahn R. The cDNA and derived amino acid sequences for rat and human synaptophysin. Nucleic Acids Research. 15: 9607. PMID 3120152 DOI: 10.1093/NAR/15.22.9607  0.325
1987 Südhof TC, Russell DW, Brown MS, Goldstein JL. 42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter. Cell. 48: 1061-9. PMID 3030558 DOI: 10.1016/0092-8674(87)90713-6  0.528
1987 Silva FG, Sherrill K, Spurgeon S, Südhof TC, Stone DK. High-level expression of the 32.5-kilodalton calelectrin in ductal epithelia as revealed by immunocytochemistry. Differentiation; Research in Biological Diversity. 33: 175-83. PMID 2952539 DOI: 10.1111/J.1432-0436.1986.TB00423.X  0.314
1986 Russell DW, Lehrman MA, Südhof TC, Yamamoto T, Davis CG, Hobbs HH, Brown MS, Goldstein JL. The LDL receptor in familial hypercholesterolemia: use of human mutations to dissect a membrane protein. Cold Spring Harbor Symposia On Quantitative Biology. 51: 811-9. PMID 3472763 DOI: 10.1101/Sqb.1986.051.01.094  0.686
1986 Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL, Brown MS. Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proceedings of the National Academy of Sciences of the United States of America. 83: 8370-4. PMID 3464957 DOI: 10.1073/Pnas.83.21.8370  0.502
1985 Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI. Cassette of eight exons shared by genes for LDL receptor and EGF precursor. Science (New York, N.Y.). 228: 893-5. PMID 3873704 DOI: 10.1126/Science.3873704  0.53
1985 Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW. Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains. Science (New York, N.Y.). 227: 140-6. PMID 3155573 DOI: 10.1126/Science.3155573  0.553
1985 Südhof TC, Goldstein JL, Brown MS, Russell DW. The LDL receptor gene: a mosaic of exons shared with different proteins. Science (New York, N.Y.). 228: 815-22. PMID 2988123 DOI: 10.1126/Science.2988123  0.55
Low-probability matches (unlikely to be authored by this person)
1997 Nguyen T, Südhof TC. Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules. The Journal of Biological Chemistry. 272: 26032-9. PMID 9325340 DOI: 10.1074/jbc.272.41.26032  0.299
2004 Hoffman RC, Jennings LL, Tsigelny I, Comoletti D, Flynn RE, Sudhof TC, Taylor P. Structural characterization of recombinant soluble rat neuroligin 1: mapping of secondary structure and glycosylation by mass spectrometry. Biochemistry. 43: 1496-506. PMID 14769026 DOI: 10.1021/Bi035278T  0.298
1998 Rizo J, Südhof TC. C2-domains, structure and function of a universal Ca2+-binding domain. The Journal of Biological Chemistry. 273: 15879-82. PMID 9632630 DOI: 10.1074/jbc.273.26.15879  0.297
2022 Zhou B, Lu JG, Siddu A, Wernig M, Südhof TC. Synaptogenic effect of -Swedish mutation in familial Alzheimer's disease. Science Translational Medicine. 14: eabn9380. PMID 36260691 DOI: 10.1126/scitranslmed.abn9380  0.292
1998 Khvotchev M, Südhof TC. Developmentally regulated alternative splicing in a novel synaptojanin. The Journal of Biological Chemistry. 273: 2306-11. PMID 9442075 DOI: 10.1074/jbc.273.4.2306  0.291
2010 Barbu EM, Ganesh VK, Gurusiddappa S, Mackenzie RC, Foster TJ, Sudhof TC, Höök M. beta-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. Plos Pathogens. 6: e1000726. PMID 20090838 DOI: 10.1371/Journal.Ppat.1000726  0.288
2019 Dong J, Lee Y, Kirmiz M, Palacio S, Dumitras C, Moreno CM, Sando R, Santana LF, Südhof TC, Gong B, Murray KD, Trimmer JS. Author response: A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons Elife. DOI: 10.7554/Elife.48750.022  0.288
2005 Fornai F, Schlüter OM, Lenzi P, Gesi M, Ruffoli R, Ferrucci M, Lazzeri G, Busceti CL, Pontarelli F, Battaglia G, Pellegrini A, Nicoletti F, Ruggieri S, Paparelli A, Südhof TC. Parkinson-like syndrome induced by continuous MPTP infusion: convergent roles of the ubiquitin-proteasome system and alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 102: 3413-8. PMID 15716361 DOI: 10.1073/Pnas.0409713102  0.286
2014 Xu J, Bacaj T, Zhou A, Tomchick DR, Südhof TC, Rizo J. Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2. Structure (London, England : 1993). 22: 269-80. PMID 24373768 DOI: 10.1016/j.str.2013.11.011  0.285
2015 Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, et al. Propagation of prions causing synucleinopathies in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E4949-58. PMID 26286986 DOI: 10.1073/Pnas.1513426112  0.283
2014 Burré J, Sharma M, Südhof TC. α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America. 111: E4274-83. PMID 25246573 DOI: 10.1073/Pnas.1416598111  0.283
2017 Burré J, Sharma M, Südhof TC. Cell Biology and Pathophysiology of α-Synuclein. Cold Spring Harbor Perspectives in Medicine. PMID 28108534 DOI: 10.1101/Cshperspect.A024091  0.281
2006 Comoletti D, Flynn RE, Boucard AA, Demeler B, Schirf V, Shi J, Jennings LL, Newlin HR, Südhof TC, Taylor P. Gene selection, alternative splicing, and post-translational processing regulate neuroligin selectivity for beta-neurexins. Biochemistry. 45: 12816-27. PMID 17042500 DOI: 10.1021/Bi0614131  0.28
2015 Burré J, Sharma M, Südhof TC. Definition of a molecular pathway mediating α-synuclein neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5221-32. PMID 25834048 DOI: 10.1523/Jneurosci.4650-14.2015  0.28
1995 Li X, Rosahl TW, Sudhof TC, Francke U. Mapping of synapsin II (SYN2) genes to human chromosome 3p and mouse chromosome 6 band F Cytogenetics and Cell Genetics. 71: 301-305. PMID 7587399 DOI: 10.1159/000134132  0.28
2004 Cao X, Südhof TC. Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation. The Journal of Biological Chemistry. 279: 24601-11. PMID 15044485 DOI: 10.1074/jbc.M402248200  0.279
2013 Südhof TC. A molecular machine for neurotransmitter release: synaptotagmin and beyond. Nature Medicine. 19: 1227-31. PMID 24100992 DOI: 10.1038/nm.3338  0.277
1999 Sugita S, Khvochtev M, Südhof TC. Neurexins are functional alpha-latrotoxin receptors. Neuron. 22: 489-96. PMID 10197529 DOI: 10.1016/S0896-6273(00)80704-7  0.277
1997 Wang CR, Esser L, Smagula CS, Südhof TC, Deisenhofer J. Identification, expression, and crystallization of the protease-resistant conserved domain of synapsin I. Protein Science : a Publication of the Protein Society. 6: 2264-7. PMID 9336850 DOI: 10.1002/Pro.5560061022  0.276
2002 Lu J, Garcia J, Dulubova I, Südhof TC, Rizo J. Solution structure of the Vam7p PX domain. Biochemistry. 41: 5956-62. PMID 11993989 DOI: 10.1021/Bi020050B  0.275
1989 Südhof TC, Fried VA, Stone DK, Johnston PA, Xie XS. Human endomembrane H+ pump strongly resembles the ATP-synthetase of Archaebacteria. Proceedings of the National Academy of Sciences of the United States of America. 86: 6067-71. PMID 2527371 DOI: 10.1073/PNAS.86.16.6067  0.274
1987 Südhof TC, Stone DK. Purification of calelectrins. Methods in Enzymology. 139: 30-5. PMID 2953951 DOI: 10.1016/0076-6879(87)39072-X  0.268
1998 Rizo J, Südhof TC. Mechanics of membrane fusion. Nature Structural Biology. 5: 839-42. PMID 9783736 DOI: 10.1038/2280  0.265
2021 Wang J, Miao Y, Wicklein R, Sun Z, Wang J, Jude KM, Fernandes RA, Merrill SA, Wernig M, Garcia KC, Südhof TC. RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development. Cell. PMID 34758294 DOI: 10.1016/j.cell.2021.10.016  0.262
2021 Seigneur E, Wang J, Dai J, Polepalli J, Südhof TC. Cerebellin-2 regulates a serotonergic dorsal raphe circuit that controls compulsive behaviors. Molecular Psychiatry. PMID 34158618 DOI: 10.1038/s41380-021-01187-x  0.256
2009 Tabuchi K, Etherton M, Shigemoto R, Sudhof T. Analysis of neuroligin-3 knock-in mice relevant to autism spectrum disorders Neuroscience Research. 65: S257. DOI: 10.1016/J.Neures.2009.09.1464  0.253
2002 Barylko B, Wlodarski P, Binns DD, Gerber SH, Earnest S, Sudhof TC, Grichine N, Albanesi JP. Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II. The Journal of Biological Chemistry. 277: 44366-75. PMID 12215430 DOI: 10.1074/jbc.M203241200  0.253
1997 Südhof TC. Function of Rab3 GDP-GTP exchange. Neuron. 18: 519-22. PMID 9136761 DOI: 10.1016/S0896-6273(00)80292-5  0.251
2016 Lu YC, Nazarko OV, Sando R, Salzman GS, Li N, Südhof TC, Araç D. CorrectionStructural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion Structure. DOI: 10.1016/J.Str.2016.01.006  0.249
2020 Sclip A, Südhof TC. Author response: LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses Elife. DOI: 10.7554/Elife.53406.Sa2  0.245
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