Francesco Ramirez - Publications

Affiliations: 
Pharmacology and System Biology Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Neuroscience Biology

144 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tran PHT, Skrba T, Wondimu E, Galatioto G, Svensson RB, Olesen AT, Mackey AL, Magnusson SP, Ramirez F, Kjaer M. The influence of fibrillin-1 and physical activity upon tendon tissue morphology and mechanical properties in mice. Physiological Reports. 7: e14267. PMID 31724332 DOI: 10.14814/Phy2.14267  0.328
2019 Hansen J, Galatioto J, Caescu CI, Arnaud P, Calizo RC, Spronck B, Murtada SI, Borkar R, Weinberg A, Azeloglu EU, Bintanel-Morcillo M, Gallo JM, Humphrey JD, Jondeau G, Boileau C, ... Ramirez F, et al. Systems pharmacology-based integration of human and mouse data for drug repurposing to treat thoracic aneurysms. Jci Insight. 4. PMID 31167969 DOI: 10.1172/Jci.Insight.127652  0.332
2018 Mecham RP, Ramirez F. Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis. Current Topics in Developmental Biology. 130: 193-216. PMID 29853177 DOI: 10.1016/Bs.Ctdb.2018.02.001  0.315
2018 Cikach FS, Koch CD, Mead TJ, Galatioto J, Willard BB, Emerton KB, Eagleton MJ, Blackstone EH, Ramirez F, Roselli EE, Apte SS. Massive aggrecan and versican accumulation in thoracic aortic aneurysm and dissection. Jci Insight. 3. PMID 29515038 DOI: 10.1172/Jci.Insight.97167  0.31
2018 Galatioto J, Caescu CI, Hansen J, Cook J, Miramontes I, Iyengar R, Ramirez F. Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29371244 DOI: 10.1161/Atvbaha.117.310609  0.367
2017 Ramirez F, Caescu C, Wondimu E, Galatioto J. Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFβ signaling and cell stemness. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 28782645 DOI: 10.1016/J.Matbio.2017.07.004  0.406
2017 Bellini C, Bersi MR, Caulk AW, Ferruzzi J, Milewicz DM, Ramirez F, Rifkin DB, Tellides G, Yanagisawa H, Humphrey JD. Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms. Journal of the Royal Society, Interface. 14. PMID 28490606 DOI: 10.1098/Rsif.2016.1036  0.339
2017 Milewicz DM, Prakash SK, Ramirez F. Therapeutics Targeting Drivers of Thoracic Aortic Aneurysms and Acute Aortic Dissections: Insights from Predisposing Genes and Mouse Models. Annual Review of Medicine. 68: 51-67. PMID 28099082 DOI: 10.1146/Annurev-Med-100415-022956  0.325
2016 Lee JJ, Galatioto J, Rao S, Ramirez F, Costa KD. Losartan Attenuates Degradation of Aorta and Lung Tissue Micromechanics in a Mouse Model of Severe Marfan Syndrome. Annals of Biomedical Engineering. PMID 27090893 DOI: 10.1007/S10439-016-1616-4  0.331
2015 Zilberberg L, Phoon CK, Robertson I, Dabovic B, Ramirez F, Rifkin DB. Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112: 14012-7. PMID 26494287 DOI: 10.1073/Pnas.1507652112  0.381
2015 Cook JR, Carta L, Galatioto J, Ramirez F. Cardiovascular manifestations in Marfan syndrome and related diseases; multiple genes causing similar phenotypes. Clinical Genetics. 87: 11-20. PMID 24867163 DOI: 10.1111/Cge.12436  0.348
2015 Bellini C, Korneva A, Zilberberg L, Ramirez F, Rifkin DB, Humphrey JD. Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome Journal of Biomechanics. DOI: 10.1016/J.Jbiomech.2015.11.059  0.305
2014 Cook JR, Carta L, Bénard L, Chemaly ER, Chiu E, Rao SK, Hampton TG, Yurchenco P, Costa KD, Hajjar RJ, Ramirez F. Abnormal muscle mechanosignaling triggers cardiomyopathy in mice with Marfan syndrome. The Journal of Clinical Investigation. 124: 1329-39. PMID 24531548 DOI: 10.1172/Jci71059  0.376
2014 Nistala H, Lee-Arteaga S, Carta L, Cook JR, Smaldone S, Siciliano G, Rifkin AN, Dietz HC, Rifkin DB, Ramirez F. Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome [Human Molecular Genetics (2010) 19,24, 4790-4798] DOI: 10.1093/hmg/ddq409 Human Molecular Genetics. 23: 6137. DOI: 10.1093/hmg/ddu452  0.753
2013 Arellanes-Robledo J, Reyes-Gordillo K, Shah R, Domínguez-Rosales JA, Hernández-Nazara ZH, Ramirez F, Rojkind M, Lakshman MR. Fibrogenic actions of acetaldehyde are β-catenin dependent but Wingless independent: a critical role of nucleoredoxin and reactive oxygen species in human hepatic stellate cells. Free Radical Biology & Medicine. 65: 1487-96. PMID 23880292 DOI: 10.1016/J.Freeradbiomed.2013.07.017  0.302
2012 Pekar O, Benjamin S, Weidberg H, Smaldone S, Ramirez F, Horowitz M. EHD2 shuttles to the nucleus and represses transcription. The Biochemical Journal. 444: 383-94. PMID 22448906 DOI: 10.1042/Bj20111268  0.303
2012 Ramirez F, Rifkin DB. Is losartan the drug for all seasons? Current Opinion in Pharmacology. 12: 223-4. PMID 22445547 DOI: 10.1016/J.Coph.2012.02.007  0.307
2012 Cook JR, Smaldone S, Cozzolino C, del Solar M, Lee-Arteaga S, Nistala H, Ramirez F. Generation of Fbn1 conditional null mice implicates the extracellular microfibrils in osteoprogenitor recruitment. Genesis (New York, N.Y. : 2000). 50: 635-41. PMID 22374917 DOI: 10.1002/Dvg.22022  0.76
2011 Smaldone S, Carta L, Ramirez F. Establishment of fibrillin-deficient osteoprogenitor cell lines identifies molecular abnormalities associated with extracellular matrix perturbation of osteogenic differentiation. Cell and Tissue Research. 344: 511-7. PMID 21538048 DOI: 10.1007/S00441-011-1167-9  0.35
2011 Arteaga-Solis E, Sui-Arteaga L, Kim M, Schaffler MB, Jepsen KJ, Pleshko N, Ramirez F. Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils. Matrix Biology : Journal of the International Society For Matrix Biology. 30: 188-94. PMID 21440062 DOI: 10.1016/J.Matbio.2011.03.004  0.359
2011 Mariko B, Pezet M, Escoubet B, Bouillot S, Andrieu JP, Starcher B, Quaglino D, Jacob MP, Huber P, Ramirez F, Faury G. Fibrillin-1 genetic deficiency leads to pathological ageing of arteries in mice. The Journal of Pathology. 224: 33-44. PMID 21432852 DOI: 10.1002/Path.2840  0.368
2010 Olivieri J, Smaldone S, Ramirez F. Fibrillin assemblies: extracellular determinants of tissue formation and fibrosis. Fibrogenesis & Tissue Repair. 3: 24. PMID 21126338 DOI: 10.1186/1755-1536-3-24  0.404
2010 Nistala H, Lee-Arteaga S, Carta L, Cook JR, Smaldone S, Siciliano G, Rifkin AN, Dietz HC, Rifkin DB, Ramirez F. Differential effects of alendronate and losartan therapy on osteopenia and aortic aneurysm in mice with severe Marfan syndrome. Human Molecular Genetics. 19: 4790-8. PMID 20871099 DOI: 10.1093/Hmg/Ddq409  0.786
2010 Nistala H, Lee-Arteaga S, Smaldone S, Siciliano G, Carta L, Ono RN, Sengle G, Arteaga-Solis E, Levasseur R, Ducy P, Sakai LY, Karsenty G, Ramirez F. Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation. The Journal of Cell Biology. 190: 1107-21. PMID 20855508 DOI: 10.1083/Jcb.201003089  0.774
2010 Nistala H, Lee-Arteaga S, Smaldone S, Siciliano G, Ramirez F. Extracellular microfibrils control osteoblast-supported osteoclastogenesis by restricting TGF{beta} stimulation of RANKL production. The Journal of Biological Chemistry. 285: 34126-33. PMID 20729550 DOI: 10.1074/Jbc.M110.125328  0.787
2010 Cook JR, Nistala H, Ramirez F. Drug-based therapies for vascular disease in Marfan syndrome: from mouse models to human patients. The Mount Sinai Journal of Medicine, New York. 77: 366-73. PMID 20687182 DOI: 10.1002/Msj.20200  0.77
2010 Caiazzo M, Colucci-D'Amato L, Esposito MT, Parisi S, Stifani S, Ramirez F, di Porzio U. Transcription factor KLF7 regulates differentiation of neuroectodermal and mesodermal cell lineages. Experimental Cell Research. 316: 2365-76. PMID 20580711 DOI: 10.1016/J.Yexcr.2010.05.021  0.335
2010 Charbonneau NL, Carlson EJ, Tufa S, Sengle G, Manalo EC, Carlberg VM, Ramirez F, Keene DR, Sakai LY. In vivo studies of mutant fibrillin-1 microfibrils. The Journal of Biological Chemistry. 285: 24943-55. PMID 20529844 DOI: 10.1074/Jbc.M110.130021  0.357
2010 Charbonneau NL, Jordan CD, Keene DR, Lee-Arteaga S, Dietz HC, Rifkin DB, Ramirez F, Sakai LY. Microfibril structure masks fibrillin-2 in postnatal tissues. The Journal of Biological Chemistry. 285: 20242-51. PMID 20404337 DOI: 10.1074/Jbc.M109.087031  0.319
2010 Nistala H, Lee-Arteaga S, Siciliano G, Smaldone S, Ramirez F. Extracellular regulation of transforming growth factor beta and bone morphogenetic protein signaling in bone. Annals of the New York Academy of Sciences. 1192: 253-6. PMID 20392244 DOI: 10.1111/J.1749-6632.2009.05350.X  0.774
2010 Su J, Gorse K, Ramirez F, Fox MA. Collagen XIX is expressed by interneurons and contributes to the formation of hippocampal synapses. The Journal of Comparative Neurology. 518: 229-53. PMID 19937713 DOI: 10.1002/Cne.22228  0.306
2010 Ramirez F, Sakai LY. Biogenesis and function of fibrillin assemblies. Cell and Tissue Research. 339: 71-82. PMID 19513754 DOI: 10.1007/S00441-009-0822-X  0.393
2010 Nistala H, Rifkin A, Arteaga SL, Solar Md, Carta L, Ramirez F. Differential effects of angiotensin II-receptor blockade on vascular and skeletal manifestations of Marfan syndrome Bone. 46. DOI: 10.1016/J.Bone.2010.01.054  0.747
2009 Ramirez F, Rifkin DB. Extracellular microfibrils: contextual platforms for TGFbeta and BMP signaling. Current Opinion in Cell Biology. 21: 616-22. PMID 19525102 DOI: 10.1016/J.Ceb.2009.05.005  0.337
2009 Ramirez F, Dietz HC. Extracellular microfibrils in vertebrate development and disease processes. The Journal of Biological Chemistry. 284: 14677-81. PMID 19188363 DOI: 10.1074/Jbc.R900004200  0.323
2009 Carta L, Smaldone S, Zilberberg L, Loch D, Dietz HC, Rifkin DB, Ramirez F. p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice. The Journal of Biological Chemistry. 284: 5630-6. PMID 19109253 DOI: 10.1074/Jbc.M806962200  0.394
2009 Dabovic B, Chen Y, Choi J, Vassallo M, Dietz HC, Ramirez F, von Melchner H, Davis EC, Rifkin DB. Dual functions for LTBP in lung development: LTBP-4 independently modulates elastogenesis and TGF-beta activity. Journal of Cellular Physiology. 219: 14-22. PMID 19016471 DOI: 10.1002/Jcp.21643  0.302
2008 Matsuo N, Tanaka S, Yoshioka H, Koch M, Gordon MK, Ramirez F. Collagen XXIV (Col24a1) gene expression is a specific marker of osteoblast differentiation and bone formation. Connective Tissue Research. 49: 68-75. PMID 18382892 DOI: 10.1080/03008200801913502  0.388
2008 Ramirez F, Carta L, Lee-Arteaga S, Liu C, Nistala H, Smaldone S. Fibrillin-rich microfibrils - Structural and instructive determinants of mammalian development and physiology Connective Tissue Research. 49: 1-6. PMID 18293172 DOI: 10.1080/03008200701820708  0.772
2008 Xiong W, Knispel RA, Dietz HC, Ramirez F, Baxter BT. Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome. Journal of Vascular Surgery. 47: 166-72; discussion 1. PMID 18178469 DOI: 10.1016/J.Jvs.2007.09.016  0.324
2008 Nistala H, Lee-Arteaga S, Smaldone S, Ramirez F. Extracellular regulators of TGF-β signaling in bone Matrix Biology. 27: 60-61. DOI: 10.1016/J.Matbio.2008.09.426  0.76
2008 Carta L, Smaldone S, Zilberberg L, Lock D, Dietz HC, Rifkin DB, Ramirez F. MAPKp38 determines Smad2/3 signaling in the fbn1 null mouse aorta Matrix Biology. 27: 40. DOI: 10.1016/J.Matbio.2008.09.341  0.304
2007 Ramirez F, Dietz HC. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events. Journal of Cellular Physiology. 213: 326-30. PMID 17708531 DOI: 10.1002/Jcp.21189  0.387
2007 Ramirez F, Sakai LY, Rifkin DB, Dietz HC. Extracellular microfibrils in development and disease. Cellular and Molecular Life Sciences : Cmls. 64: 2437-46. PMID 17585369 DOI: 10.1007/S00018-007-7166-Z  0.364
2007 Ramirez F, Dietz HC. Marfan syndrome: from molecular pathogenesis to clinical treatment. Current Opinion in Genetics & Development. 17: 252-8. PMID 17467262 DOI: 10.1016/J.Gde.2007.04.006  0.346
2007 Cohn RD, van Erp C, Habashi JP, Soleimani AA, Klein EC, Lisi MT, Gamradt M, ap Rhys CM, Holm TM, Loeys BL, Ramirez F, Judge DP, Ward CW, Dietz HC. Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nature Medicine. 13: 204-10. PMID 17237794 DOI: 10.1038/Nm1536  0.315
2007 Tanaka S, Ramirez F. The first intron of the human alpha2(I) collagen gene (COL1A2) contains a novel interferon-gamma responsive element. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 185-9. PMID 17142024 DOI: 10.1016/J.Matbio.2006.10.009  0.321
2007 Kajimura D, Dragomir C, Ramirez F, Laub F. Identification of genes regulated by transcription factor KLF7 in differentiating olfactory sensory neurons. Gene. 388: 34-42. PMID 17123745 DOI: 10.1016/J.Gene.2006.09.027  0.324
2007 Kavukcuoglu NB, Arteaga-Solis E, Lee-Arteaga S, Ramirez F, Mann AB. Nanomechanics and Raman spectroscopy of fibrillin 2 knock-out mouse bones Journal of Materials Science. 42: 8788-8794. DOI: 10.1007/S10853-007-1918-X  0.342
2006 Smaldone S, Ramirez F. Multiple pathways regulate intracellular shuttling of MoKA, a co-activator of transcription factor KLF7. Nucleic Acids Research. 34: 5060-8. PMID 16990251 DOI: 10.1093/Nar/Gkl659  0.312
2006 Ramirez F, Tanaka S, Bou-Gharios G. Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases. Matrix Biology : Journal of the International Society For Matrix Biology. 25: 365-72. PMID 16815696 DOI: 10.1016/J.Matbio.2006.05.002  0.345
2006 Laub F, Dragomir C, Ramirez F. Mice without transcription factor KLF7 provide new insight into olfactory bulb development. Brain Research. 1103: 108-13. PMID 16814267 DOI: 10.1016/J.Brainres.2006.05.065  0.309
2006 Habashi JP, Judge DP, Holm TM, Cohn RD, Loeys BL, Cooper TK, Myers L, Klein EC, Liu G, Calvi C, Podowski M, Neptune ER, Halushka MK, Bedja D, Gabrielson K, ... ... Ramirez F, et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (New York, N.Y.). 312: 117-21. PMID 16601194 DOI: 10.1126/Science.1124287  0.345
2006 Robinson PN, Arteaga-Solis E, Baldock C, Collod-Béroud G, Booms P, De Paepe A, Dietz HC, Guo G, Handford PA, Judge DP, Kielty CM, Loeys B, Milewicz DM, Ney A, Ramirez F, et al. The molecular genetics of Marfan syndrome and related disorders. Journal of Medical Genetics. 43: 769-87. PMID 16571647 DOI: 10.1136/Jmg.2005.039669  0.348
2006 Carta L, Pereira L, Arteaga-Solis E, Lee-Arteaga SY, Lenart B, Starcher B, Merkel CA, Sukoyan M, Kerkis A, Hazeki N, Keene DR, Sakai LY, Ramirez F. Fibrillins 1 and 2 perform partially overlapping functions during aortic development. The Journal of Biological Chemistry. 281: 8016-23. PMID 16407178 DOI: 10.1074/Jbc.M511599200  0.371
2006 Matsuo N, Tanaka S, Gordon MK, Koch M, Yoshioka H, Ramirez F. CREB-AP1 protein complexes regulate transcription of the collagen XXIV gene (Col24a1) in osteoblasts. The Journal of Biological Chemistry. 281: 5445-52. PMID 16373341 DOI: 10.1074/Jbc.M509923200  0.387
2006 Matsumoto N, Kubo A, Liu H, Akita K, Laub F, Ramirez F, Keller G, Friedman SL. Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6. Blood. 107: 1357-65. PMID 16234353 DOI: 10.1182/Blood-2005-05-1916  0.345
2006 Antoniv T, Tanaka S, Ramirez F, Bougharios G. Transcriptional regulation of the human alpha2(I) collagen gene Matrix Biology. 25. DOI: 10.1016/J.Matbio.2006.08.215  0.313
2005 Dietz HC, Loeys B, Carta L, Ramirez F. Recent progress towards a molecular understanding of Marfan syndrome. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics. 139: 4-9. PMID 16273535 DOI: 10.1002/Ajmg.C.30068  0.37
2005 Antoniv TT, Tanaka S, Sudan B, De Val S, Liu K, Wang L, Wells DJ, Bou-Gharios G, Ramirez F. Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2). The Journal of Biological Chemistry. 280: 35417-23. PMID 16091368 DOI: 10.1074/Jbc.M502681200  0.35
2005 Svegliati-Baroni G, Inagaki Y, Rincon-Sanchez AR, Else C, Saccomanno S, Benedetti A, Ramirez F, Rojkind M. Early response of alpha2(I) collagen to acetaldehyde in human hepatic stellate cells is TGF-beta independent. Hepatology (Baltimore, Md.). 42: 343-52. PMID 16025520 DOI: 10.1002/Hep.20798  0.325
2005 Wang L, Tanaka S, Ramirez F. GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts. Matrix Biology : Journal of the International Society For Matrix Biology. 24: 333-40. PMID 15982862 DOI: 10.1016/J.Matbio.2005.06.001  0.348
2005 Laub F, Lei L, Sumiyoshi H, Kajimura D, Dragomir C, Smaldone S, Puche AC, Petros TJ, Mason C, Parada LF, Ramirez F. Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system. Molecular and Cellular Biology. 25: 5699-711. PMID 15964824 DOI: 10.1128/Mcb.25.13.5699-5711.2005  0.304
2004 Ramirez F, Dietz HC. Therapy insight: aortic aneurysm and dissection in Marfan's syndrome. Nature Clinical Practice. Cardiovascular Medicine. 1: 31-6. PMID 16265257 DOI: 10.1038/Ncpcardio0020  0.339
2004 Tanaka S, Antoniv TT, Liu K, Wang L, Wells DJ, Ramirez F, Bou-Gharios G. Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice. The Journal of Biological Chemistry. 279: 56024-31. PMID 15516691 DOI: 10.1074/Jbc.M411406200  0.332
2004 Ramirez F, Sakai LY, Dietz HC, Rifkin DB. Fibrillin microfibrils: multipurpose extracellular networks in organismal physiology. Physiological Genomics. 19: 151-4. PMID 15466717 DOI: 10.1152/Physiolgenomics.00092.2004  0.343
2004 Chanut-Delalande H, Bonod-Bidaud C, Cogne S, Malbouyres M, Ramirez F, Fichard A, Ruggiero F. Development of a functional skin matrix requires deposition of collagen V heterotrimers. Molecular and Cellular Biology. 24: 6049-57. PMID 15199158 DOI: 10.1128/Mcb.24.13.6049-6057.2004  0.319
2004 Smaldone S, Laub F, Else C, Dragomir C, Ramirez F. Identification of MoKA, a novel F-box protein that modulates Krüppel-like transcription factor 7 activity. Molecular and Cellular Biology. 24: 1058-69. PMID 14729953 DOI: 10.1128/Mcb.24.3.1058-1069.2004  0.306
2003 De Graeve F, Smaldone S, Laub F, Mlodzik M, Bhat M, Ramirez F. Identification of the Drosophila progenitor of mammalian Krüppel-like factors 6 and 7 and a determinant of fly development. Gene. 314: 55-62. PMID 14527717 DOI: 10.1016/S0378-1119(03)00720-0  0.327
2003 Ohnishi S, Ohnami S, Laub F, Aoki K, Suzuki K, Kanai Y, Haga K, Asaka M, Ramirez F, Yoshida T. Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer. Biochemical and Biophysical Research Communications. 308: 251-6. PMID 12901861 DOI: 10.1016/S0006-291X(03)01356-1  0.32
2003 Koch M, Laub F, Zhou P, Hahn RA, Tanaka S, Burgeson RE, Gerecke DR, Ramirez F, Gordon MK. Collagen XXIV, a vertebrate fibrillar collagen with structural features of invertebrate collagens: selective expression in developing cornea and bone. The Journal of Biological Chemistry. 278: 43236-44. PMID 12874293 DOI: 10.1074/Jbc.M302112200  0.333
2003 Ramirez F, Rifkin DB. Cell signaling events: a view from the matrix. Matrix Biology : Journal of the International Society For Matrix Biology. 22: 101-7. PMID 12782137 DOI: 10.1016/S0945-053X(03)00002-7  0.327
2003 Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, Dietz HC. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Nature Genetics. 33: 407-11. PMID 12598898 DOI: 10.1038/Ng1116  0.385
2001 Chen Y, Sumiyoshi H, Oxford JT, Yoshioka H, Ramirez F, Morris NP. Cis-acting elements regulate alternative splicing of exons 6A, 6B and 8 of the alpha1(XI) collagen gene and contribute to the regional diversification of collagen XI matrices. Matrix Biology : Journal of the International Society For Matrix Biology. 20: 589-99. PMID 11731275 DOI: 10.1016/S0945-053X(01)00169-X  0.323
2001 Arteaga-Solis E, Gayraud B, Lee SY, Shum L, Sakai L, Ramirez F. Regulation of limb patterning by extracellular microfibrils. The Journal of Cell Biology. 154: 275-81. PMID 11470817 DOI: 10.1083/Jcb.200105046  0.387
2001 Antoniv TT, De Val S, Wells D, Denton CP, Rabe C, de Crombrugghe B, Ramirez F, Bou-Gharios G. Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene. The Journal of Biological Chemistry. 276: 21754-64. PMID 11279244 DOI: 10.1074/Jbc.M101397200  0.374
2001 Sumiyoshi H, Laub F, Yoshioka H, Ramirez F. Embryonic expression of type XIX collagen is transient and confined to muscle cells. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 220: 155-62. PMID 11169848 DOI: 10.1002/1097-0177(2000)9999:9999<::Aid-Dvdy1099>3.0.Co;2-W  0.331
2001 Bunton TE, Biery NJ, Myers L, Gayraud B, Ramirez F, Dietz HC. Phenotypic alteration of vascular smooth muscle cells precedes elastolysis in a mouse model of Marfan syndrome. Circulation Research. 88: 37-43. PMID 11139471 DOI: 10.1161/01.Res.88.1.37  0.366
2001 Zhang W, Ou J, Inagaki Y, Greenwel P, Ramirez F. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription. The Journal of Biological Chemistry. 275: 39237-45. PMID 11007770 DOI: 10.1074/Jbc.M003339200  0.329
2000 Laub F, Aldabe R, Ou J, Ramirez F. Overexpression of a novel zinc-finger protein induces apoptosis in NIH3T3 fibroblasts. Genomics. 70: 375-80. PMID 11161788 DOI: 10.1006/Geno.2000.6420  0.308
2000 Gayraud B, Keene DR, Sakai LY, Ramirez F. New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. The Journal of Cell Biology. 150: 667-80. PMID 10931876 DOI: 10.1083/Jcb.150.3.667  0.408
2000 Arteaga-Solis E, Gayraud B, Ramirez F. Elastic and collagenous networks in vascular diseases. Cell Structure and Function. 25: 69-72. PMID 10885576 DOI: 10.1247/Csf.25.69  0.349
2000 Ohnishi S, Laub F, Matsumoto N, Asaka M, Ramirez F, Yoshida T, Terada M. Developmental expression of the mouse gene coding for the Krüppel-like transcription factor KLF5. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 217: 421-9. PMID 10767086 DOI: 10.1002/(Sici)1097-0177(200004)217:4<421::Aid-Dvdy9>3.0.Co;2-1  0.302
2000 Penkov D, Ni R, Else C, Piñol-Roma S, Ramirez F, Tanaka S. Cloning of a human gene closely related to the genes coding for the c-myc single-strand binding proteins. Gene. 243: 27-36. PMID 10675610 DOI: 10.1016/S0378-1119(99)00515-6  0.321
1999 Ramirez F, Gayraud B, Pereira L. Marfan syndrome: new clues to genotype-phenotype correlations. Annals of Medicine. 31: 202-7. PMID 10442675 DOI: 10.3109/07853899909115979  0.356
1999 Ramirez F, Pereira L. Mutations of extracellular matrix components in vascular disease Annals of Thoracic Surgery. 67: 1857-1858. PMID 10391325 DOI: 10.1016/S0003-4975(99)00437-3  0.389
1999 Ramirez F, Pereira L. The fibrillins International Journal of Biochemistry and Cell Biology. 31: 255-259. PMID 10216958 DOI: 10.1016/S1357-2725(98)00109-5  0.357
1999 Pereira L, Lee SY, Gayraud B, Andrikopoulos K, Shapiro SD, Bunton T, Biery NJ, Dietz HC, Sakai LY, Ramirez F. Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1. Proceedings of the National Academy of Sciences of the United States of America. 96: 3819-23. PMID 10097121 DOI: 10.1073/Pnas.96.7.3819  0.35
1998 Matsumoto N, Laub F, Aldabe R, Zhang W, Ramirez F, Yoshida T, Terada M. Cloning the cDNA for a new human zinc finger protein defines a group of closely related Krüppel-like transcription factors. The Journal of Biological Chemistry. 273: 28229-37. PMID 9774444 DOI: 10.1074/Jbc.273.43.28229  0.312
1997 Pereira L, Andrikopoulos K, Tian J, Lee SY, Keene DR, Ono R, Reinhardt DP, Sakai LY, Biery NJ, Bunton T, Dietz HC, Ramirez F. Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nature Genetics. 17: 218-22. PMID 9326947 DOI: 10.1038/Ng1097-218  0.365
1997 Greenwel P, Inagaki Y, Hu W, Walsh M, Ramirez F. Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1. The Journal of Biological Chemistry. 272: 19738-45. PMID 9242631 DOI: 10.1074/Jbc.272.32.19738  0.307
1996 Ramirez F. Fibrillin mutations in Marfan syndrome and related phenotypes Current Opinion in Genetics and Development. 6: 309-315. PMID 8791520 DOI: 10.1016/S0959-437X(96)80007-4  0.333
1996 Sakamoto H, Broekelmann T, Cheresh DA, Ramirez F, Rosenbloom J, Mecham RP. Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1 Journal of Biological Chemistry. 271: 4916-4922. PMID 8617764 DOI: 10.1074/Jbc.271.9.4916  0.301
1996 Yoshioka H, Iyama K, Inoguchi K, Khaleduzzaman M, Ninomiya Y, Ramirez F. Developmental pattern of expression of the mouse alpha 1 (XI) collagen gene (Col11a1). Developmental Dynamics : An Official Publication of the American Association of Anatomists. 204: 41-7. PMID 8563024 DOI: 10.1002/Aja.1002040106  0.375
1996 Yoshioka H, Inoguchi K, Khaleduzzaman M, Ninomiya Y, Andrikopoulos K, Ramirez F. Coding sequence and alternative splicing of the mouse alpha 1(XI) collagen gene (Col11a1). Genomics. 28: 337-40. PMID 8530046 DOI: 10.1006/Geno.1995.1151  0.309
1996 Putnam EA, Zhang H, Ramirez F, Milewicz DM. Fibrillin-2 (FBN2) mutations result in the Marfan-like disorder, congenital contractural arachnodactyly. Nature Genetics. 11: 456-8. PMID 7493032 DOI: 10.1038/Ng1295-456  0.337
1995 Greenwel P, Hu W, Kohanski RA, Ramirez F. Tyrosine dephosphorylation of nuclear proteins mimics transforming growth factor β1 stimulation of α2(I) collagen gene expression Molecular and Cellular Biology. 15: 6813-6819. PMID 8524247 DOI: 10.1128/Mcb.15.12.6813  0.327
1995 Li Y, Lacerda DA, Warman ML, Beier DR, Yoshioka H, Ninomiya Y, Oxford JT, Morris NP, Andrikopoulos K, Ramirez F. A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell. 80: 423-30. PMID 7859283 DOI: 10.1016/0092-8674(95)90492-1  0.307
1995 Inagaki Y, Truter S, Tanaka S, Di Liberto M, Ramirez F. Overlapping pathways mediate the opposing actions of tumor necrosis factor-alpha and transforming growth factor-beta on alpha 2(I) collagen gene transcription. The Journal of Biological Chemistry. 270: 3353-8. PMID 7852421 DOI: 10.1074/Jbc.270.7.3353  0.323
1995 Yin W, Smiley E, Germiller J, Sanguineti C, Lawton T, Pereira L, Ramirez F, Bonadio J. Primary structure and developmental expression of Fbn-1, the mouse fibrillin gene. The Journal of Biological Chemistry. 270: 1798-806. PMID 7829516 DOI: 10.1074/Jbc.270.4.1798  0.34
1995 Yoshioka H, Greenwel P, Inoguchi K, Truter S, Inagaki Y, Ninomiya Y, Ramirez F. Structural and functional analysis of the promoter of the human alpha 1(XI) collagen gene. The Journal of Biological Chemistry. 270: 418-24. PMID 7814404 DOI: 10.1074/Jbc.270.1.418  0.361
1995 Zhang H, Hu W, Ramirez F. Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils. The Journal of Cell Biology. 129: 1165-76. PMID 7744963 DOI: 10.1083/Jcb.129.4.1165  0.344
1995 Andrikopoulos K, Liu X, Keene DR, Jaenisch R, Ramirez F. Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nature Genetics. 9: 31-6. PMID 7704020 DOI: 10.1038/Ng0195-31  0.38
1995 Mariencheck MC, Davis EC, Zhang H, Ramirez F, Rosenbloom J, Gibson MA, Parks WC, Mecham RP. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues Connective Tissue Research. 31: 87-97. DOI: 10.3109/03008209509028396  0.306
1995 Inagaki Y, Truter S, Greenwel P, Rojkind M, Unoura M, Kobayashi K, Ramirez F. Regulation of the α2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver Hepatology. 22: 573-579. DOI: 10.1002/Hep.1840220230  0.329
1994 Zhang H, Apfelroth SD, Hu W, Davis EC, Sanguineti C, Bonadio J, Mecham RP, Ramirez F. Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices Journal of Cell Biology. 124: 855-863. PMID 8120105 DOI: 10.1083/Jcb.124.5.855  0.318
1994 Pereira L, Levran O, Ramirez F, Lynch JR, Sykes B, Pyeritz RE, Dietz HC. A molecular approach to the stratification of cardiovascular risk in families with Marfan's syndrome New England Journal of Medicine. 331: 148-153. PMID 8008028 DOI: 10.1056/Nejm199407213310302  0.33
1994 Yoshioka H, Iyama K, Inoguchi K, Khaleduzzaman M, Kamagata Y, Andrikopoulos K, Ramirez F, Ninomiya Y. Expression of the α1(XI) collagen gene in mouse embryonic tissues Matrix Biology. 14: 365. DOI: 10.1016/0945-053X(94)90062-0  0.336
1993 Truter S, Andrikopoulos K, Di Liberto M, Womack L, Ramirez F. Pro-alpha 2(V) collagen gene; pairwise analysis of the amino-propeptide coding domain, and cross-species comparison of the promoter sequence. Connective Tissue Research. 29: 51-9. PMID 8339546 DOI: 10.3109/03008209309061966  0.31
1993 Pereira L, D'Alessio M, Ramirez F, Lynch JR, Sykes B, Pangilinan T, Bonadio J. Genomic organization of the sequence coding for fibrillin, the defective gene product in Marfan syndrome. Human Molecular Genetics. 2: 1762. PMID 8268958 DOI: 10.1093/Hmg/2.10.1762  0.371
1993 Ramirez F, Pereira L, Zhang H, Lee B. The fibrillin-Marfan syndrome connection. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 15: 589-94. PMID 8240311 DOI: 10.1002/Bies.950150904  0.544
1993 Ramirez F, Solursh M. Expression of vertebrate homologs of the Drosophila msh gene during early craniofacial development Integrative and Comparative Biology. 33: 457-461. DOI: 10.1093/Icb/33.4.457  0.331
1992 Yoshioka H, Zhang H, Ramirez F, Mattei MG, Moradi-Ameli M, van der Rest M, Gordon MK. Synteny between the loci for a novel FACIT-like collagen locus (D6S228E) and alpha 1 (IX) collagen (COL9A1) on 6q12-q14 in humans. Genomics. 13: 884-6. PMID 1639419 DOI: 10.1016/0888-7543(92)90176-S  0.331
1992 Tsipouras P, Del Mastro R, Sarfarazi M, Lee B, Vitale E, Child AH, Godfrey M, Devereux RB, Hewett D, Steinmann B, Viljoen D, Sykes BC, Kilpatrick M, Ramirez F, Farndon PA, et al. Genetic linkage of the Marfan syndrome, ectopia lentis, and congenital contractural arachnodactyly to the fibrillin genes on chromosomes 15 and 5 New England Journal of Medicine. 326: 905-909. PMID 1542340 DOI: 10.1056/Nejm199204023261401  0.509
1992 Parker ML, Smith AA, Mundell K, Collins M, Boast S, Ramirez F. The abolition of collagen gene expression in SV40-transformed fibroblasts is associated with trans-acting factor switching Nucleic Acids Research. 20: 5825-5830. PMID 1333588 DOI: 10.1093/Nar/20.21.5825  0.347
1992 Andrikopoulos K, Suzuki HR, Solursh M, Ramirez F. Localization of pro-alpha 2(V) collagen transcripts in the tissues of the developing mouse embryo. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 195: 113-20. PMID 1297453 DOI: 10.1002/Aja.1001950205  0.36
1992 Padanilam BJ, Stadler HS, Mills KA, McLeod LB, Solursh M, Lee B, Ramirez F, Buetow KH, Murray JC. Characterization of the human HOX 7 cDNA and identification of polymorphic markers. Human Molecular Genetics. 1: 407-10. PMID 1284527 DOI: 10.1093/Hmg/1.6.407  0.487
1991 Su MW, Suzuki HR, Bieker JJ, Solursh M, Ramirez F. Expression of two nonallelic type II procollagen genes during Xenopus laevis embryogenesis is characterized by stage-specific production of alternatively spliced transcripts. The Journal of Cell Biology. 115: 565-75. PMID 1918153 DOI: 10.1083/Jcb.115.2.565  0.342
1991 Lee B, Godfrey M, Vitale E, Hori H, Mattei MG, Sarfarazi M, Tsipouras P, Ramirez F, Hollister DW. Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes. Nature. 352: 330-4. PMID 1852206 DOI: 10.1038/352330A0  0.527
1991 Suzuki HR, Padanilam BJ, Vitale E, Ramirez F, Solursh M. Repeating developmental expression of G-Hox 7, a novel homeobox-containing gene in the chicken. Developmental Biology. 148: 375-88. PMID 1682191 DOI: 10.1016/0012-1606(91)90345-4  0.311
1990 Su MW, Lee B, Ramirez F, Machado M, Horton W. Nucleotide sequence of the full length cDNA encoding for human type II procollagen. Nucleic Acids Research. 17: 9473. PMID 2587267 DOI: 10.1093/Nar/17.22.9473  0.472
1990 Ramirez F, Boast S, D'Alessio M, Lee B, Prince J, Su MW, Vissing H, Yoshioka H. Fibrillar collagen genes. Structure and expression in normal and diseased states Annals of the New York Academy of Sciences. 580: 74-80. PMID 2186697 DOI: 10.1111/J.1749-6632.1990.Tb17919.X  0.475
1990 Ramirez F, Di Liberto M. Complex and diversified regulatory programs control the expression of vertebrate collagen genes Faseb Journal. 4: 1616-1623. PMID 2180769 DOI: 10.1096/Fasebj.4.6.2180769  0.362
1990 Kahari V, Chen YQ, Su MW, Ramirez F, Uitto J. Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional levels. Journal of Clinical Investigation. 86: 1489-1495. PMID 2122979 DOI: 10.1172/Jci114866  0.328
1990 Vissing H, Rasmussen M, D'alessio M, Lee B, Dobkin C, Ramirez F. A glycine to serine polymorphism in the C-propeptide of the human type II procollagen Nucleic Acids Research. 18: 3431. PMID 1972570 DOI: 10.1093/Nar/18.11.3431  0.456
1990 LEE B, VISSING H, RAMIREZ F, ROGERS D, RIMOIN D. Single Exon Deletion in One COL2A1 Allele in Spondyloepiphyseal Dysplasia Annals of the New York Academy of Sciences. 580: 562-563. DOI: 10.1111/J.1749-6632.1990.Tb17993.X  0.464
1990 Vissing H, Lee B, D'Alessio M, Ramirez F, Byers P, Superti-Furga A, Steinmann B. Characterization of large deletions in the pro-α1(III) mRNA from two Ehlers-Danlos type IV patients Annals of the New York Academy of Sciences. 580: 552-553. DOI: 10.1111/J.1749-6632.1990.Tb17988.X  0.462
1989 D'Alessio M, Ramirez F, Suzuki HR, Solursh M, Gambino R. Structure and developmental expression of a sea urchin fibrillar collagen gene. Proceedings of the National Academy of Sciences of the United States of America. 86: 9303-7. PMID 2594770 DOI: 10.1073/Pnas.86.23.9303  0.342
1989 Lee B, Vissing H, Ramirez F, Rogers D, Rimoin D. Identification of the molecular defect in a family with spondyloepiphyseal dysplasia. Science (New York, N.Y.). 244: 978-80. PMID 2543071 DOI: 10.1126/Science.2543071  0.531
1987 Ahti H, Palotie A, Peltonen L, Ramirez F. DNA-polymorphism of type I collagen gene detected with Bgl II in the genetically isolated Finnish population. Human Genetics. 75: 79-80. PMID 3026951 DOI: 10.1007/Bf00273846  0.301
1987 Tsipouras P, Schwartz RC, Goldberg JD, Berkowitz RL, Ramirez F. Prenatal prediction of osteogenesis imperfecta (OI type IV): exclusion of inheritance using a collagen gene probe Journal of Medical Genetics. 24: 406-409. PMID 2886666 DOI: 10.1136/Jmg.24.7.406  0.337
1986 Ramirez F, Bernard M, Chu ML, Dickson L, Sangiorgi F, Weil D, De Wet W, Junien C, Sobel M. Isolation and characterization of the human fibrillar collagen genes. Annals of the New York Academy of Sciences. 460: 117-29. PMID 3868939 DOI: 10.1111/J.1749-6632.1985.Tb51160.X  0.342
1985 Dickson LA, de Wet W, Di Liberto M, Weil D, Ramirez F. Analysis of the promoter region and the N-propeptide domain of the human pro alpha 2(I) collagen gene. Nucleic Acids Research. 13: 3427-38. PMID 4011429 DOI: 10.1093/Nar/13.10.3427  0.33
1985 Uitto J, Perejda AJ, Abergel RP, Chu ML, Ramirez F. Altered steady-state ratio of type I/III procollagen mRNAs correlates with selectively increased type I procollagen biosynthesis in cultured keloid fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 82: 5935-9. PMID 3862108 DOI: 10.1073/Pnas.82.17.5935  0.307
1985 Sangiorgi FO, Benson-Chanda V, de Wet WJ, Sobel ME, Tsipouras P, Ramirez F. Isolation and partial characterization of the entire human proα I(II) collagen gene Nucleic Acids Research. 13: 2207-2225. PMID 2987845 DOI: 10.1093/Nar/13.7.2207  0.335
1985 Tsipouras P, Chu M, Sangiorgi FO, Weil D, Ramirez F. 866 DNA MARKERS ASSOCIATED WITH HUMAN PROCOLLAGEN GENES Pediatric Research. 19: 255A-255A. DOI: 10.1203/00006450-198504000-00896  0.343
1985 WET W, SIPPOLA M, BERNARD M, PROCKOP D, CHU M, RAMIREZ F. Electronmicroscopic Localization of Deletions in the Human Pro-?2(I) Collagen Gene Annals of the New York Academy of Sciences. 460: 415-418. DOI: 10.1111/J.1749-6632.1985.Tb51196.X  0.326
1984 Chu ML, de Wet W, Bernard M, Ding JF, Morabito M, Myers J, Williams C, Ramirez F. Human pro alpha 1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons. Nature. 310: 337-40. PMID 6462220 DOI: 10.1038/310337A0  0.32
1983 Tsipouras P, Myers JC, Ramirez F, Prockop DJ. Restriction fragment length polymorphism associated with the Proα2(I) gene of human type I procollagen. Application to a family with an autosomal dominant form of osteogenesis imperfecta Journal of Clinical Investigation. 72: 1262-1267. PMID 6313757 DOI: 10.1172/Jci111082  0.303
1983 Chu ML, Williams CJ, Pepe G, Hirsch JL, Prockop DJ, Ramirez F. Internal deletion in a collagen gene in a perinatal lethal form of osteogenesis imperfecta. Nature. 304: 78-80. PMID 6191221 DOI: 10.1038/304078A0  0.363
1981 Baird M, Driscoll C, Schreiner H, Sciarratta GV, Sansone G, Niazi G, Ramirez F, Bank A. A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 78: 4218-21. PMID 6270663 DOI: 10.1073/Pnas.78.7.4218  0.313
1981 Ramirez F, Mears JG, Bank A. The molecular basis of disorders of human hemoglobin synthesis. Molecular and Cellular Biochemistry. 31: 133-45. PMID 6255309 DOI: 10.1007/Bf00225847  0.316
1980 Bank A, Mears JG, Ramirez F. Disorders of human hemoglobin. Science (New York, N.Y.). 207: 486-93. PMID 7352255 DOI: 10.1126/Science.7352255  0.353
1980 Bank A, Mears JG, Ramirez F, Burns AL, Spence S, Feldenzer J, Baird M. The organization of the gamma-delta-beta gene complex in normal and thalassemia cells. Hemoglobin. 4: 497-507. PMID 6252123 DOI: 10.3109/03630268008996230  0.303
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