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Thomas P. Sakmar, Ph.D. - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Website:
http://www.rockefeller.edu/research/faculty/labheads/ThomasSakmar/
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Year Citation  Score
2023 Kazmi MA, Thaler DS, Åberg KC, Mattheisen JM, Huber T, Sakmar TP. The Coronavirus Calendar (CoronaCal): a simplified SARS-CoV-2 test system for sampling and retrospective analysis. Frontiers in Epidemiology. 3: 1146006. PMID 38455914 DOI: 10.3389/fepid.2023.1146006  0.717
2023 Kotliar IB, Bendes A, Dahl L, Chen Y, Saarinen M, Ceraudo E, Dodig-Crnković T, Uhlén M, Svenningsson P, Schwenk JM, Sakmar TP. Expanding the GPCR-RAMP interactome. Biorxiv : the Preprint Server For Biology. PMID 38045268 DOI: 10.1101/2023.11.22.568247  0.317
2023 Mattheisen JM, Rasmussen VA, Ceraudo E, Kolodzinski A, Horioka-Duplix M, Sakmar TP, Huber T. Application of bioluminescence resonance energy transfer to quantitate cell-surface expression of membrane proteins. Analytical Biochemistry. 115361. PMID 37865268 DOI: 10.1016/j.ab.2023.115361  0.777
2023 Mattheisen JM, Limberakis C, Ruggeri RB, Dowling MS, Am Ende CW, Ceraudo E, Huber T, McClendon CL, Sakmar TP. Bioorthogonal Tethering Enhances Drug Fragment Affinity for G Protein-Coupled Receptors in Live Cells. Journal of the American Chemical Society. PMID 37116188 DOI: 10.1021/jacs.3c00972  0.781
2023 Kotliar IB, Ceraudo E, Kemelmakher-Liben K, Oren DA, Lorenzen E, Dodig-Crnković T, Horioka-Duplix M, Huber T, Schwenk JM, Sakmar TP. Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins (RAMPs). The Journal of Biological Chemistry. 104664. PMID 37003505 DOI: 10.1016/j.jbc.2023.104664  0.356
2022 Kotliar IB, Lorenzen E, Schwenk JM, Hay DL, Sakmar TP. Elucidating the Interactome of G Protein-Coupled Receptors and Receptor Activity-Modifying Proteins. Pharmacological Reviews. 75: 1-34. PMID 36757898 DOI: 10.1124/pharmrev.120.000180  0.347
2022 Mattheisen JM, Wollowitz JS, Huber T, Sakmar TP. Genetic Code Expansion To Enable Site-Specific Bioorthogonal Labeling of Functional G Protein-Coupled Receptors in Live Cells. Protein Science : a Publication of the Protein Society. e4550. PMID 36540928 DOI: 10.1002/pro.4550  0.789
2022 Tian H, Gunnison KM, Kazmi MA, Sakmar TP, Huber T. FRET sensors reveal the retinal entry pathway in the G protein-coupled receptor rhodopsin. Iscience. 25: 104060. PMID 35355518 DOI: 10.1016/j.isci.2022.104060  0.48
2020 Ceraudo E, Horioka M, Mattheisen JM, Hitchman TD, Moore AR, Kazmi MA, Chi P, Chen Y, Sakmar TP, Huber T. Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling. The Journal of Biological Chemistry. PMID 33288675 DOI: 10.1074/jbc.RA120.015352  0.774
2020 Horioka M, Huber T, Sakmar TP. Playing Tag with Your Favorite GPCR Using CRISPR. Cell Chemical Biology. 27: 642-644. PMID 32559501 DOI: 10.1016/J.Chembiol.2020.06.001  0.367
2019 van Husen LS, Schedin-Weiss S, Trung MN, Kazmi MA, Winblad B, Sakmar TP, Elsässer SJ, Tjernberg LO. Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products. Journal of Alzheimer's Disease : Jad. PMID 31609694 DOI: 10.3233/Jad-190898  0.362
2019 Lorenzen E, Dodig-Crnković T, Kotliar IB, Pin E, Ceraudo E, Vaughan RD, Uhlèn M, Huber T, Schwenk JM, Sakmar TP. Multiplexed analysis of the secretin-like GPCR-RAMP interactome. Science Advances. 5: eaaw2778. PMID 31555726 DOI: 10.1126/sciadv.aaw2778  0.339
2019 Gagnon L, Cao Y, Cho A, Sedki D, Huber T, Sakmar TP, Laporte SA. Genetic code expansion and photocross-linking identify different β-arrestin binding modes to the angiotensin II type 1 receptor. The Journal of Biological Chemistry. PMID 31530642 DOI: 10.1074/Jbc.Ra119.010324  0.405
2019 Rico CA, Berchiche YA, Horioka M, Peeler JC, Lorenzen E, Tian H, Kazmi MA, Fürstenberg A, Gaertner H, Hartley O, Sakmar TP, Huber T. High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Coreceptor CCR5. Biophysical Journal. PMID 31421836 DOI: 10.1016/J.Bpj.2019.07.043  0.523
2019 Yuan L, Barbash S, Kongsamut S, Eishingdrelo A, Sakmar TP, Eishingdrelo H. 14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking. Scientific Reports. 9: 11156. PMID 31371790 DOI: 10.1038/S41598-019-47478-W  0.405
2019 Krause BS, Kaufmann JCD, Kuhne J, Vierock J, Huber T, Sakmar TP, Gerwert K, Bartl F, Hegemann P. Tracking pore hydration in channelrhodopsin by site-directed infrared-active azido probes. Biochemistry. PMID 30702875 DOI: 10.1021/Acs.Biochem.8B01211  0.309
2019 Lorenzen E, Sakmar TP. Receptor Structures for a Caldron of Cannabinoids. Cell. 176: 409-411. PMID 30682366 DOI: 10.1016/J.Cell.2019.01.012  0.333
2019 Huber T, Sakmar TP. Third-Party Capture of Elusive GPCR Dimers. Biophysical Journal. 116: 1-3. PMID 30558887 DOI: 10.1016/J.Bpj.2018.11.018  0.339
2018 Barbash S, Persson T, Lorenzen E, Kazmi MA, Huber T, Sakmar TP. Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins. Iscience. 11: 366-374. PMID 30660104 DOI: 10.1016/J.Isci.2018.12.024  0.431
2018 Lorenzen E, Ceraudo E, Berchiche YA, Rico CA, Fürstenberg A, Sakmar TP, Huber T. G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs. Science Signaling. 11. PMID 30327411 DOI: 10.1126/Scisignal.Aao6152  0.386
2018 Simms J, Uddin R, Sakmar TP, Gingell JJ, Garelja ML, Hay DL, Brimble MA, Harris PWR, Reynolds CA, Poyner DR. Photoaffinity cross-linking and unnatural amino acid mutagenesis reveal insights into calcitonin gene-related peptide binding to the calcitonin receptor-like receptor/receptor activity-modifying protein 1 (CLR/RAMP1) complex. Biochemistry. PMID 30004692 DOI: 10.1021/Acs.Biochem.8B00502  0.442
2018 Huber T, Sakmar TP. Probing Antibody Binding Sites on G Protein-Coupled Receptors Using Genetically Encoded Photo-Activatable Cross-Linkers. Methods in Molecular Biology (Clifton, N.J.). 1785: 65-75. PMID 29714012 DOI: 10.1007/978-1-4939-7841-0_5  0.423
2017 Peeler JC, Schedin-Weiss S, Soula M, Kazmi MA, Sakmar TP. Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4. The Journal of Biological Chemistry. PMID 29101232 DOI: 10.1074/Jbc.M116.758961  0.361
2017 Barbash S, Lorenzen E, Persson T, Huber T, Sakmar TP. GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078385 DOI: 10.1073/Pnas.1713074114  0.427
2017 Tian H, Sakmar TP, Huber T. The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin. Biophysical Journal. 113: 60-72. PMID 28700926 DOI: 10.1016/J.Bpj.2017.05.036  0.547
2017 Koole C, Reynolds CA, Mobarec JC, Hick C, Sexton PM, Sakmar TP. Genetically-Encoded Photocrosslinkers Determine the Biological Binding Site of Exendin-4 in the N-Terminal Domain of the Intact Human Glucagon-Like Peptide-1 Receptor (GLP-1R). The Journal of Biological Chemistry. PMID 28283573 DOI: 10.1074/Jbc.M117.779496  0.432
2017 Tian H, Sakmar TP, Huber T. Measurement of Slow Spontaneous Release of 11-cis-Retinal from Rhodopsin. Biophysical Journal. 112: 153-161. PMID 28076806 DOI: 10.1016/J.Bpj.2016.12.005  0.469
2017 Sakmar TP. Introduction: G-Protein Coupled Receptors. Chemical Reviews. 117: 1-3. PMID 28073249 DOI: 10.1021/Acs.Chemrev.6B00686  0.423
2016 Sakmar TP, Huber T. Pharmacology: Inside-out receptor inhibition. Nature. PMID 27926728 DOI: 10.1038/Nature20486  0.41
2016 Berchiche YA, Sakmar TP. CXC Chemokine Receptor 3 Alternative Splice Variants Selectively Activate Different Signaling Pathways. Molecular Pharmacology. PMID 27512119 DOI: 10.1124/Mol.116.105502  0.415
2016 Rannversson H, Andersen J, Sørensen L, Bang-Andersen B, Park M, Huber T, Sakmar TP, Strømgaard K. Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter. Nature Communications. 7: 11261. PMID 27089947 DOI: 10.1038/Ncomms11261  0.316
2016 Moore AR, Ceraudo E, Sher JJ, Guan Y, Shoushtari AN, Chang MT, Zhang JQ, Walczak EG, Kazmi MA, Taylor BS, Huber T, Chi P, Sakmar TP, Chen Y. Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma. Nature Genetics. PMID 27089179 DOI: 10.1038/Ng.3549  0.36
2016 Tian H, Sakmar TP, Huber T. A simple method for enhancing the bioorthogonality of cyclooctyne reagent. Chemical Communications (Cambridge, England). PMID 27009873 DOI: 10.1039/C6Cc01321J  0.461
2016 Seibert C, Sanfiz A, Sakmar TP, Veldkamp CT. Preparation and Analysis of N-Terminal Chemokine Receptor Sulfopeptides Using Tyrosylprotein Sulfotransferase Enzymes. Methods in Enzymology. 570: 357-88. PMID 26921955 DOI: 10.1016/Bs.Mie.2015.09.004  0.394
2015 Park M, Sivertsen BB, Els-Heindl S, Huber T, Holst B, Beck-Sickinger AG, Schwartz TW, Sakmar TP. Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics. Chemistry & Biology. PMID 26548612 DOI: 10.1016/J.Chembiol.2015.09.014  0.488
2015 Park M, Tian H, Naganathan S, Sakmar TP, Huber T. Quantitative Multi-color Detection Strategies for Bioorthogonally Labeled GPCRs. Methods in Molecular Biology (Clifton, N.J.). 1335: 67-93. PMID 26260595 DOI: 10.1007/978-1-4939-2914-6_6  0.572
2015 Tian H, Sakmar TP, Huber T. Micelle-Enhanced Bioorthogonal Labeling of Genetically Encoded Azido Groups on the Lipid-Embedded Surface of a GPCR. Chembiochem : a European Journal of Chemical Biology. 16: 1314-22. PMID 25962668 DOI: 10.1002/Cbic.201500030  0.559
2015 Naganathan S, Ray-Saha S, Park M, Tian H, Sakmar TP, Huber T. Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acids. Biochemistry. 54: 776-86. PMID 25524496 DOI: 10.1021/Bi501267X  0.595
2015 Staljanssens D, Rico CA, Park M, Van Camp J, Yu N, Huber T, Sakmar TP, Smagghe G. Development of a CCK1R-membrane nanoparticle as a fish-out tool for bioactive peptides. Peptides. 68: 219-27. PMID 25451329 DOI: 10.1016/J.Peptides.2014.10.015  0.399
2015 Huber T, Sakmar TP. Novel Chemical Biology Methods Illuminate the Function of Single G Protein-Coupled Receptors Biophysical Journal. 108: 96a. DOI: 10.1016/J.Bpj.2014.11.554  0.496
2015 Tian H, Sakmar T, Huber T. The Energetics of the Chromophore Regeneration Pathway in Rhodopsin Biophysical Journal. 108: 259a. DOI: 10.1016/J.Bpj.2014.11.1432  0.516
2015 Tian H, Sakmar TP, Huber T. Cover Picture: Micelle-Enhanced Bioorthogonal Labeling of Genetically Encoded Azido Groups on the Lipid-Embedded Surface of a GPCR (ChemBioChem 9/2015) Chembiochem. 16: 1249-1249. DOI: 10.1002/Cbic.201590021  0.443
2014 Huber T, Sakmar TP. Chemical biology methods for investigating G protein-coupled receptor signaling Chemistry and Biology. 21: 1224-1237. PMID 25237865 DOI: 10.1016/J.Chembiol.2014.08.009  0.495
2014 Tian H, Naganathan S, Kazmi MA, Schwartz TW, Sakmar TP, Huber T. Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. Chembiochem : a European Journal of Chemical Biology. 15: 1820-9. PMID 25045132 DOI: 10.1002/Cbic.201402193  0.578
2014 Valentin-Hansen L, Park M, Huber T, Grunbeck A, Naganathan S, Schwartz TW, Sakmar TP. Mapping Substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid Journal of Biological Chemistry. 289: 18045-18054. PMID 24831006 DOI: 10.1074/Jbc.M113.527085  0.454
2014 Ray-Saha S, Huber T, Sakmar TP. Antibody epitopes on G protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers Biochemistry. 53: 1302-1310. PMID 24490954 DOI: 10.1021/Bi401289P  0.39
2014 Rico CA, Sakmar TP, Huber T. Optimized Zebrafish Apolipoprotein A-I Expression and Purification for Nabbs Assembly Biophysical Journal. 106: 104a-105a. DOI: 10.1016/J.Bpj.2013.11.647  0.393
2014 Krause BS, Hegemann P, Huber T, Sakmar TP. Site-Specific Tagging of Channelrhodopsins with Genetically-Encoded Azido Groups Biophysical Journal. 106: 381a. DOI: 10.1016/J.Bpj.2013.11.2155  0.437
2014 Tian H, Gunnison KM, Kazmi M, Sakmar TP, Huber T. Mutagenesis Study of Retinal Entry Pathway of Rhodopsin Biophysical Journal. 106: 306a. DOI: 10.1016/J.Bpj.2013.11.1775  0.549
2014 Periole X, Sakmar TP, Marrink SJ, Huber T. Supramolecular Organization of Rod Outer Segment Membrane: New Rhodopsin Dimer Interface and Insights from the β2Ar-Gs Complex Biophysical Journal. 106: 305a-306a. DOI: 10.1016/J.Bpj.2013.11.1772  0.416
2014 Huber T, Fürstenberg A, Tian H, Gaertner HF, Hartley O, Sakmar TP. Multi-Color, Single-Molecule Fluorescence Imaging of GPCR Signalosomes Biophysical Journal. 106: 2-8. DOI: 10.1016/J.Bpj.2013.11.1395  0.577
2013 Sekharan S, Mooney VL, Rivalta I, Kazmi MA, Neitz M, Neitz J, Sakmar TP, Yan EC, Batista VS. Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism. Journal of the American Chemical Society. 135: 19064-7. PMID 24295328 DOI: 10.1021/Ja409896Y  0.612
2013 Grunbeck A, Sakmar TP. Probing G protein-coupled receptor-ligand interactions with targeted photoactivatable cross-linkers. Biochemistry. 52: 8625-32. PMID 24199838 DOI: 10.1021/Bi401300Y  0.444
2013 Tian H, Sakmar TP, Huber T. Site-Specific Labeling of Genetically Encoded Azido Groups for Multicolor, Single-Molecule Fluorescence Imaging of GPCRs Methods in Cell Biology. 117: 267-303. PMID 24143983 DOI: 10.1016/B978-0-12-408143-7.00015-3  0.558
2013 Naganathan S, Grunbeck A, Tian H, Huber T, Sakmar TP. Genetically-encoded molecular probes to study G protein-coupled receptors. Journal of Visualized Experiments : Jove. PMID 24056801 DOI: 10.3791/50588  0.609
2013 Knepp AM, Sakmar TP, Huber T. Homogeneous time-resolved fluorescence assay to probe folded G protein-coupled receptors Methods in Enzymology. 522: 169-189. PMID 23374186 DOI: 10.1016/B978-0-12-407865-9.00010-8  0.465
2013 Grunbeck A, Huber T, Sakmar TP. Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers Methods in Enzymology. 520: 307-322. PMID 23332706 DOI: 10.1016/B978-0-12-391861-1.00014-9  0.412
2013 Huber T, Naganathan S, Tian H, Ye S, Sakmar TP. Unnatural amino acid mutagenesis of GPCRs using amber codon suppression and bioorthogonal labeling Methods in Enzymology. 520: 281-305. PMID 23332705 DOI: 10.1016/B978-0-12-391861-1.00013-7  0.56
2013 Naganathan S, Ye S, Sakmar TP, Huber T. Site-specific epitope tagging of G protein-coupled receptors by bioorthogonal modification of a genetically encoded unnatural amino acid Biochemistry. 52: 1028-1036. PMID 23317030 DOI: 10.1021/Bi301292H  0.47
2013 Rico CA, Knepp AM, Peeler JC, Sakmar TP, Huber T. Incorporation of Fluorescently Tagged Chemokine Receptor 5 (CCR5) into Membrane Nanoparticles Biophysical Journal. 104: 115a. DOI: 10.1016/J.Bpj.2012.11.668  0.475
2013 Park M, Huber T, Behrens Sivertsen B, Holst B, Schwartz TW, Sakmar TP. Visualizing Ghrelin Receptor through Genetically Encoded Labeling for Monitoring the Single-Molecule Conformational Dynamics Biophysical Journal. 104: 612a. DOI: 10.1016/J.Bpj.2012.11.3392  0.475
2013 Tian H, Sakmar TP, Huber T. Site-Specific Bioorthogonal Labeling of a G Protein-Coupled Receptor at a Genetically Encoded Azido Amino Acid Biophysical Journal. 104: 27a. DOI: 10.1016/J.Bpj.2012.11.186  0.623
2012 Sakmar TP. Redder than red Science. 338: 1299-1300. PMID 23224543 DOI: 10.1126/Science.1231589  0.322
2012 Periole X, Knepp AM, Sakmar TP, Marrink SJ, Huber T. Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers Journal of the American Chemical Society. 134: 10959-10965. PMID 22679925 DOI: 10.1021/Ja303286E  0.433
2012 Grunbeck A, Huber T, Abrol R, Trzaskowski B, Goddard WA, Sakmar TP. Genetically encoded photo-cross-linkers map the binding site of an allosteric drug on a G protein-coupled receptor Acs Chemical Biology. 7: 967-972. PMID 22455376 DOI: 10.1021/Cb300059Z  0.451
2012 Knepp AM, Periole X, Marrink SJ, Sakmar TP, Huber T. Rhodopsin forms a dimer with cytoplasmic helix 8 contacts in native membranes Biochemistry. 51: 1819-1821. PMID 22352709 DOI: 10.1021/Bi3001598  0.388
2012 Siderius M, Wal M, Scholten DJ, Smit MJ, Sakmar TP, Leurs R, De Graaf C. Unnatural amino acids for the study of chemokine receptor structure and dynamics Drug Discovery Today: Technologies. 9: e301-e313. DOI: 10.1016/J.Ddtec.2012.07.008  0.471
2012 Sakmar TP. Probing GPCR Signaling with Genetically-Encoded Non-Natural Amino Acids Biophysical Journal. 102: 609a. DOI: 10.1016/J.Bpj.2011.11.3320  0.463
2012 Tian H, Naganathan S, Ye S, Sakmar TP, Huber T. Dual-Color Fluorescent Labeling of G Protein-Coupled Receptors Biophysical Journal. 102: 518a. DOI: 10.1016/J.Bpj.2011.11.2831  0.586
2012 Huber T, Periole X, Knepp AM, Marrink S, Mukhopadhyay P, Sakmar TP. Dynamic Assembly of the Receptor-G-Protein Signaling Complex Biophysical Journal. 102: 516a. DOI: 10.1016/J.Bpj.2011.11.2823  0.446
2012 Grunbeck A, Huber T, Sakmar TP. Identification of a Small Molecule-Ligand-Binding Pocket in a G Protein-Coupled Receptor using Genetically-Encoded Photocrosslinkers Biophysical Journal. 102: 240a. DOI: 10.1016/J.Bpj.2011.11.1320  0.484
2012 Knepp AM, Periole X, Mukhopadhyay P, Marrink SJ, Sakmar TP, Huber T. Biochemical Crosslinking and Liquid Chromatography-Mass Spectrometry Demonstrate a Rhodopsin Dimerization Interface Mediated by Helices 1 and 8 Biophysical Journal. 102: 239a. DOI: 10.1016/J.Bpj.2011.11.1315  0.408
2012 Farrens DL, Sakmar TP. Contributions of H G Khorana to understanding transmembrane signal transduction Resonance. 17: 1165-1173. DOI: 10.1007/S12045-012-0133-5  0.43
2011 Janz JM, Ren Y, Looby R, Kazmi MA, Sachdev P, Grunbeck A, Haggis L, Chinnapen D, Lin AY, Seibert C, McMurry T, Carlson KE, Muir TW, Hunt S, Sakmar TP. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. Journal of the American Chemical Society. 133: 15878-81. PMID 21905700 DOI: 10.1021/Ja206661W  0.463
2011 Dimond P, Carlson K, Bouvier M, Gerard C, Xu L, Covic L, Agarwal A, Ernst OP, Janz JM, Schwartz TW, Gardella TJ, Milligan G, Kuliopulos A, Sakmar TP, Hunt SW. G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Annals of the New York Academy of Sciences. 1226: 34-49. PMID 21615752 DOI: 10.1111/J.1749-6632.2011.06039.X  0.333
2011 Daggett KA, Sakmar TP. Site-specific in vitro and in vivo incorporation of molecular probes to study G-protein-coupled receptors Current Opinion in Chemical Biology. 15: 392-398. PMID 21571577 DOI: 10.1016/j.cbpa.2011.03.010  0.408
2011 Grunbeck A, Huber T, Sachdev P, Sakmar TP. Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers Biochemistry. 50: 3411-3413. PMID 21417335 DOI: 10.1021/Bi200214R  0.466
2011 Knepp AM, Grunbeck A, Banerjee S, Sakmar TP, Huber T. Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands Biochemistry. 50: 502-511. PMID 21155586 DOI: 10.1021/Bi101059W  0.41
2011 Huber T, Sakmar TP. Novel Trifunctional Bio-Orthogonal Reagents for Microscale Stoichiometric Labeling of Proteins for Single-Molecule Fluorescence Studies of Signalosomes Biophysical Journal. 100: 256a-257a. DOI: 10.1016/J.Bpj.2010.12.1618  0.442
2011 Tian H, Naganathan S, Ye S, Sakmar TP, Huber T. Site-Specific Fluorescent Labeling of G Protein-Coupled Receptors Biophysical Journal. 100: 256a. DOI: 10.1016/J.Bpj.2010.12.1617  0.558
2011 Huber T, Mukhopadhyay P, Sakmar TP. Structural Dynamics of a Signalosome: The Receptor-G protein Complex Biophysical Journal. 100: 255a. DOI: 10.1016/J.Bpj.2010.12.1610  0.459
2011 Knepp AM, Grunbeck A, Banerjee S, Sakmar TP, Huber T. High-Throughput Measurement of GPCR Stability At Femtomole Scale Biophysical Journal. 100: 178a. DOI: 10.1016/J.Bpj.2010.12.1192  0.417
2010 Hou HJM, Sakmar TP. Methodology of pulsed photoacoustics and its application to probe photosystems and receptors Sensors. 10: 5642-5667. PMID 22219680 DOI: 10.3390/S100605642  0.733
2010 Tchernychev B, Ren Y, Sachdev P, Janz JM, Haggis L, O'Shea A, McBride E, Looby R, Deng Q, McMurry T, Kazmi MA, Sakmar TP, Hunt S, Carlson KE. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 107: 22255-22259. PMID 21139054 DOI: 10.1073/Pnas.1009633108  0.356
2010 Ye S, Zaitseva E, Caltabiano G, Schertler GFX, Sakmar TP, Deupi X, Vogel R. Tracking G-protein-coupled receptor activation using genetically encoded infrared probes Nature. 464: 1386-1389. PMID 20383122 DOI: 10.1038/Nature08948  0.336
2010 Mukhopadhyay P, Sakmar TP, Huber T. Molecular Model of the Opsin-G-Protein Complex Biophysical Journal. 98: 419a. DOI: 10.1016/J.Bpj.2009.12.2265  0.398
2010 Naganathan S, Ye S, Duarte T, Huber T, Sachdev P, Sakmar TP. A Novel Method to Probe Membrane Protein Topology Using Unnatural Amino Acid Mutagenesis and Antibody Epitope Tagging Biophysical Journal. 98: 419a. DOI: 10.1016/J.Bpj.2009.12.2263  0.477
2010 Grunbeck A, Huber T, Ye S, Banerjee S, Sakmar TP. Novel Technology to Study Chemokine Receptor Signaling Complexes Biophysical Journal. 98: 292a. DOI: 10.1016/J.Bpj.2009.12.1591  0.493
2010 Ye S, Kazmi MA, Duarte T, Naganathan S, Sakmar T, Huber T. Site-Specific Fluorescent Labeling of Purified G-Protein-Coupled Receptors Using Genetically-Encoded Unnatural Amino Acids Biophysical Journal. 98: 291a-292a. DOI: 10.1016/J.Bpj.2009.12.1588  0.493
2010 Huber T, Mukhopadhyay P, Sakmar TP. Molecular Dynamics Simulations of Active Receptor-G Protein Complex in a Lipid Bilayer Biophysical Journal. 98: 289a. DOI: 10.1016/J.Bpj.2009.12.1577  0.4
2010 Knepp AM, Sakmar TP, Huber T. Quantitative GPCR Assay Using Time-Resolved Fret Biophysical Journal. 98: 287a. DOI: 10.1016/J.Bpj.2009.12.1566  0.472
2010 Sakmar TP. Examining receptor activation: New technologies reveal how G protein-coupled receptors recognise ligands and talk to intracellular partners European Pharmaceutical Review.  0.322
2009 Miller J, Agarwal A, Devi LA, Fontanini K, Hamilton JA, Pin JP, Shields DC, Spek CA, Sakmar TP, Kuliopulos A, Hunt SW. Insider access: pepducin symposium explores a new approach to GPCR modulation. Annals of the New York Academy of Sciences. 1180: E1-12. PMID 19925639 DOI: 10.1111/J.1749-6632.2009.05326.X  0.442
2009 Ahuja S, Eilers M, Hirshfeld A, Yan ECY, Ziliox M, Sakmar TP, Sheves M, Smith SO. 6-s-cis conformation and polar binding pocket of the retinal chromophore in the photoactivated state of rhodopsin Journal of the American Chemical Society. 131: 15160-15169. PMID 19795853 DOI: 10.1021/Ja9034768  0.402
2009 Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP. Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins Journal of Molecular Biology. 393: 882-897. PMID 19703466 DOI: 10.1016/J.Jmb.2009.08.043  0.392
2009 Ye S, Huber T, Vogel R, Sakmar TP. FTIR analysis of GPCR activation using azido probes Nature Chemical Biology. 5: 397-399. PMID 19396177 DOI: 10.1038/Nchembio.167  0.334
2009 Ye S, Huber T, Vogel R, Sakmar TP. Probing Conformational Changes In Rhodopsin With Site-specific Azido Labels Biophysical Journal. 96: 6a. DOI: 10.1016/J.Bpj.2008.12.927  0.494
2009 Periole X, Huber T, Marrink S, Sakmar TP. Membrane Proteins-bilayer Interplay: Insights From Coarse-grained Self-assembly And Potential Of Mean Force Simulations Of Rhodopsin In Model Bilayers Biophysical Journal. 96: 673a. DOI: 10.1016/J.Bpj.2008.12.3556  0.338
2009 Ye S, Huber T, Sakmar TP. Unnatural Amino Acid Mutagenesis For Site-specific Incorporation Of Keto And Azido Functionalities Into Functional G Protein-coupled Receptors Biophysical Journal. 96: 632a. DOI: 10.1016/J.Bpj.2008.12.3343  0.466
2009 Huber T, Sakmar TP. Structural Basis of Lipid Effects on G-Protein-Coupled Receptor (GPCR) Activation Biophysical Journal. 96: 592a-593a. DOI: 10.1016/J.Bpj.2008.12.3163  0.468
2009 Banerjee S, Grunbeck A, Huber T, Sachdev P, Sakmar TP. Rapid Incorporation of Heterologously Expressed GPCR CCR5 in Nanoscale Apolipoprotein Bound Bilayers (NABBs) Biophysical Journal. 96: 51a. DOI: 10.1016/J.Bpj.2008.12.160  0.465
2008 Seibert C, Veldkamp CT, Peterson FC, Chait BT, Volkman BF, Sakmar TP. Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases Biochemistry. 47: 11251-11262. PMID 18834145 DOI: 10.1021/Bi800965M  0.326
2008 Huber T, Menon S, Sakmar TP. Structural basis for ligand binding and specificity in adrenergic receptors: Implications for GPCR-targeted drug discovery Biochemistry. 47: 11013-11023. PMID 18821775 DOI: 10.1021/Bi800891R  0.402
2008 Banerjee S, Huber T, Sakmar TP. Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayer (NABB) Particles Journal of Molecular Biology. 377: 1067-1081. PMID 18313692 DOI: 10.1016/j.jmb.2008.01.066  0.322
2008 Ye S, Köhrer C, Huber T, Kazmi M, Sachdev P, Yan EC, Bhagat A, RajBhandary UL, Sakmar TP. Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis. The Journal of Biological Chemistry. 283: 1525-33. PMID 17993461 DOI: 10.1074/Jbc.M707355200  0.768
2007 Janz JM, Sakmar TP, Min KC. A novel interaction between atrophin-interacting protein 4 and β-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain Journal of Biological Chemistry. 282: 28893-28903. PMID 17652093 DOI: 10.1074/Jbc.M702678200  0.339
2006 Vogel R, Siebert F, Yan EC, Sakmar TP, Hirshfeld A, Sheves M. Modulating rhodopsin receptor activation by altering the pKa of the retinal Schiff base. Journal of the American Chemical Society. 128: 10503-12. PMID 16895417 DOI: 10.1021/Ja0627848  0.627
2006 Lewis JW, Szundi I, Kazmi MA, Sakmar TP, Kliger DS. Proton movement and photointermediate kinetics in rhodopsin mutants. Biochemistry. 45: 5430-9. PMID 16634624 DOI: 10.1021/Bi0525775  0.344
2006 Hoelz A, Janz JM, Lawrie SD, Corwin B, Lee A, Sakmar TP. Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2. Journal of Molecular Biology. 358: 509-22. PMID 16527308 DOI: 10.1016/J.Jmb.2006.02.027  0.667
2006 Vogel R, Lüdeke S, Siebert F, Sakmar TP, Hirshfeld A, Sheves M. Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation. Biochemistry. 45: 1640-52. PMID 16460011 DOI: 10.1021/Bi052196R  0.337
2006 Vogel R, Siebert F, Yan ECY, Sakmar TP, Hirshfeld aA, Sheves M. Modulating Rhodopsin Receptor Activation by Altering the pKa of the Retinal Schiff Base [J. Am. Chem. Soc. 2006, 128, 10503−10512]. Journal of the American Chemical Society. 128: 15034-15034. DOI: 10.1021/Ja069975V  0.367
2005 Lüdeke S, Beck M, Yan EC, Sakmar TP, Siebert F, Vogel R. The role of Glu181 in the photoactivation of rhodopsin. Journal of Molecular Biology. 353: 345-56. PMID 16169009 DOI: 10.1016/J.Jmb.2005.08.039  0.634
2004 Lewis JW, Szundi I, Kazmi MA, Sakmar TP, Kliger DS. Time-resolved photointermediate changes in rhodopsin glutamic acid 181 mutants. Biochemistry. 43: 12614-21. PMID 15449951 DOI: 10.1021/Bi049581L  0.335
2004 Yan ECY, Ganim Z, Kazmi MA, Chang BSW, Sakmar TP, Mathies RA. Resonance raman analysis of the mechanism of energy storage and chromophore distortion in the primary visual photoproduct Biochemistry. 43: 10867-10876. PMID 15323547 DOI: 10.1021/Bi0400148  0.506
2004 Seibert C, Sakmar TP. Small-molecule antagonists of CCR5 and CXCR4: A promising new class of anti-HIV-1 drugs Current Pharmaceutical Design. 10: 2041-2062. PMID 15279544 DOI: 10.2174/1381612043384312  0.328
2003 Yan ECY, Kazmi MA, Ganim Z, Hou JM, Pan D, Chang BSW, Sakmar TP, Mathies RA. Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin Proceedings of the National Academy of Sciences of the United States of America. 100: 9262-9267. PMID 12835420 DOI: 10.1073/Pnas.1531970100  0.582
2002 Unson CG, Wu CR, Jiang Y, Yoo B, Cheung C, Sakmar TP, Merrifield RB. Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Biochemistry. 41: 11795-803. PMID 12269822 DOI: 10.1021/Bi025711J  0.431
2002 Chang BS, Jönsson K, Kazmi MA, Donoghue MJ, Sakmar TP. Recreating a functional ancestral archosaur visual pigment. Molecular Biology and Evolution. 19: 1483-9. PMID 12200476 DOI: 10.1093/Oxfordjournals.Molbev.A004211  0.668
2002 Seibert C, Cadene M, Sanfiz A, Chait BT, Sakmar TP. Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence Proceedings of the National Academy of Sciences of the United States of America. 99: 11031-11036. PMID 12169668 DOI: 10.1073/Pnas.172380899  0.36
2002 Krishna AG, Menon ST, Terry TJ, Sakmar TP. Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch Biochemistry. 41: 8298-8309. PMID 12081478 DOI: 10.1021/Bi025534M  0.329
2002 Sakmar TP, Menon ST, Marin EP, Awad ES. Rhodopsin: Insights from recent structural studies Annual Review of Biophysics and Biomolecular Structure. 31: 443-484. PMID 11988478 DOI: 10.1146/annurev.biophys.31.082901.134348  0.335
2002 Sakmar TP. Structure of rhodopsin and the superfamily of seven-helical receptors: The same and not the same Current Opinion in Cell Biology. 14: 189-195. PMID 11891118 DOI: 10.1016/S0955-0674(02)00306-X  0.312
2002 Yan ECY, Kazmi MA, De S, Chang BSW, Seibert C, Marin EP, Mathies RA, Sakmar TP. Function of extracellular loop 2 in rhodopsin: Glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II Biochemistry. 41: 3620-3627. PMID 11888278 DOI: 10.1021/Bi0160011  0.554
2001 Chang BSW, Kazmi MA, Sakmar TP. Synthetic gene technology: Applications to ancestral gene reconstruction and structure-function studies of receptors Methods in Enzymology. 343: 274-294. PMID 11665573 DOI: 10.1016/S0076-6879(02)43142-4  0.401
2001 Menon ST, Han M, Sakmar TP. Rhodopsin: Structural basis of molecular physiology Physiological Reviews. 81: 1659-1688. PMID 11581499  0.342
2001 Jiang Y, Cypess AM, Muse ED, Wu CR, Unson CG, Merrifield RB, Sakmar TP. Glucagon receptor activates extracellular signal-regulated protein kinase 1/2 via cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 98: 10102-7. PMID 11517300 DOI: 10.1073/Pnas.131200398  0.317
2001 Marin EP, Krishna AG, Sakmar TP. Rapid activation of transducin by mutations distant from the nucleotide-binding site: Evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins Journal of Biological Chemistry. 276: 27400-27405. PMID 11356823 DOI: 10.1074/jbc.C100198200  0.302
2000 Fahmy K, Sakmar TP, Siebert F. Transducin-dependent protonation of glutamic acid 134 in rhodopsin. Biochemistry. 39: 10607-12. PMID 10956053 DOI: 10.1021/Bi000912D  0.36
2000 Kazmi MA, Snyder LA, Cypess AM, Graber SG, Sakmar TP. Selective reconstitution of human D4 dopamine receptor variants with Gi alpha subtypes. Biochemistry. 39: 3734-44. PMID 10736173 DOI: 10.1021/Bi992354C  0.441
2000 Lewis JW, Szundi I, Fu WY, Sakmar TP, Kliger DS. pH dependence of photolysis intermediates in the photoactivation of rhodopsin mutant E113Q. Biochemistry. 39: 599-606. PMID 10642185 DOI: 10.1021/Bi991860Z  0.346
1999 Simpson MM, Ballesteros JA, Chiappa V, Chen J, Suehiro M, Hartman DS, Godel T, Snyder LA, Sakmar TP, Javitch JA. Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments. Molecular Pharmacology. 56: 1116-26. PMID 10570038 DOI: 10.1124/Mol.56.6.1116  0.37
1999 Kochendoerfer GG, Lin SW, Sakmar TP, Mathies RA. How color visual pigments are tuned. Trends in Biochemical Sciences. 24: 300-5. PMID 10431173 DOI: 10.1016/S0968-0004(99)01432-2  0.463
1999 Cypess AM, Unson CG, Wu CR, Sakmar TP. Two cytoplasmic loops of the glucagon receptor are required to elevate cAMP or intracellular calcium Journal of Biological Chemistry. 274: 19455-19464. PMID 10383462 DOI: 10.1074/jbc.274.27.19455  0.372
1998 Lin SW, Kochendoerfer GG, Carroll KS, Wang D, Mathies RA, Sakmar TP. Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants. The Journal of Biological Chemistry. 273: 24583-91. PMID 9733753 DOI: 10.1074/Jbc.273.38.24583  0.482
1998 Han M, Smith SO, Sakmar TP. Constitutive activation of opsin by mutation of methionine 257 on transmembrane helix 6 Biochemistry. 37: 8253-8261. PMID 9609722 DOI: 10.1021/Bi980147R  0.495
1998 Beck M, Sakmar TP, Siebert F. Spectroscopic evidence for interaction between transmembrane helices 3 and 5 in rhodopsin. Biochemistry. 37: 7630-9. PMID 9585578 DOI: 10.1021/Bi9801560  0.367
1998 Sakmar TP. Rhodopsin: a prototypical G protein-coupled receptor Progress in Nucleic Acid Research and Molecular Biology. 59: 1-34. PMID 9427838  0.313
1998 Han M, Groesbeek M, Smith SO, Sakmar TP. Role of the C9 methyl group in rhodopsin activation: Characterization of mutant opsins with the artificial chromophore 11-cis-9-demethylretinal Biochemistry. 37: 538-545. PMID 9425074 DOI: 10.1021/Bi972060W  0.386
1997 Han M, Groesbeek M, Sakmar TP, Smith SO. The C9 methyl group of retinal interacts with glycine-121 in rhodopsin Proceedings of the National Academy of Sciences of the United States of America. 94: 13442-13447. PMID 9391044 DOI: 10.1073/Pnas.94.25.13442  0.418
1997 Jäger S, Han M, Lewis JW, Szundi I, Sakmar TP, Kliger DS. Properties of early photolysis intermediates of rhodopsin are affected by glycine 121 and phenylalanine 261. Biochemistry. 36: 11804-10. PMID 9305971 DOI: 10.1021/Bi971122F  0.362
1997 Han M, Lou J, Nakanishi K, Sakmar TP, Smith SO. Partial agonist activity of 11-cis-retinal in rhodopsin mutants Journal of Biological Chemistry. 272: 23081-23085. PMID 9287308 DOI: 10.1074/Jbc.272.37.23081  0.303
1997 Jäger S, Lewis JW, Zvyaga TA, Szundi I, Sakmar TP, Kliger DS. Chromophore structural changes in rhodopsin from nanoseconds to microseconds following pigment photolysis. Proceedings of the National Academy of Sciences of the United States of America. 94: 8557-62. PMID 9238015 DOI: 10.1073/Pnas.94.16.8557  0.468
1997 Shieh T, Han M, Sakmar TP, Smith SO. The steric trigger in rhodopsin activation Journal of Molecular Biology. 269: 373-384. PMID 9199406 DOI: 10.1006/Jmbi.1997.1035  0.334
1997 Jäger S, Lewis JW, Zvyaga TA, Szundi I, Sakmar TP, Kliger DS. Time-resolved spectroscopy of the early photolysis intermediates of rhodopsin Schiff base counterion mutants. Biochemistry. 36: 1999-2009. PMID 9047297 DOI: 10.1021/Bi962320U  0.332
1996 Han M, Lin SW, Minkova M, Smith SO, Sakmar TP. Functional interaction of transmembrane helices 3 and 6 in rhodopsin. Replacement of phenylalanine 261 by alanine causes reversion of phenotype of a glycine 121 replacement mutant Journal of Biological Chemistry. 271: 32337-32342. PMID 8943296 DOI: 10.1074/Jbc.271.50.32337  0.31
1996 Han M, Lin SW, Smith SO, Sakmar TP. The effects of amino acid replacements of glycine 121 on transmembrane helix 3 of rhodopsin Journal of Biological Chemistry. 271: 32330-32336. PMID 8943295 DOI: 10.1074/Jbc.271.50.32330  0.314
1996 Fahmy K, Zvyaga TA, Sakmar TP, Siebert F. Spectroscopic evidence for altered chromophore--protein interactions in low-temperature photoproducts of the visual pigment responsible for congenital night blindness. Biochemistry. 35: 15065-73. PMID 8942673 DOI: 10.1021/Bi961486S  0.374
1996 Sheikh SP, Zvyaga TA, Lichtarge O, Sakmar TP, Bourne HR. Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature. 383: 347-50. PMID 8848049 DOI: 10.1038/383347A0  0.334
1996 Zvyaga TA, Fahmy K, Siebert F, Sakmar TP. Characterization of the mutant visual pigment responsible for congenital night blindness: a biochemical and Fourier-transform infrared spectroscopy study. Biochemistry. 35: 7536-45. PMID 8652533 DOI: 10.1021/Bi960391N  0.37
1996 Unson CG, Cypess AM, Wu CR, Goldsmith PK, Merrifield RB, Sakmar TP. Antibodies against specific extracellular epitopes of the glucagon receptor block glucagon binding. Proceedings of the National Academy of Sciences of the United States of America. 93: 310-5. PMID 8552628 DOI: 10.1073/Pnas.93.1.310  0.372
1995 Unson CG, Cypess AM, Kim HN, Goldsmith PK, Carruthers CJ, Merrifield RB, Sakmar TP. Characterization of deletion and truncation mutants of the rat glucagon receptor. Seven transmembrane segments are necessary for receptor transport to the plasma membrane and glucagon binding. The Journal of Biological Chemistry. 270: 27720-7. PMID 7499239 DOI: 10.1074/jbc.270.46.27720  0.36
1994 Zvyaga TA, Fahmy K, Sakmar TP. Characterization of rhodopsin-transducin interaction: a mutant rhodopsin photoproduct with a protonated Schiff base activates transducin. Biochemistry. 33: 9753-61. PMID 8068654 DOI: 10.1021/Bi00198A046  0.381
1994 Carruthers CJL, Unson CG, Hyang Nina Kim, Sakmar TP. Synthesis and expression of a gene for the rat glucagon receptor. Replacement of an aspartic acid in the extracellular domain prevents glucagon binding Journal of Biological Chemistry. 269: 29321-29328. PMID 7961903  0.335
1994 Fahmy K, Siebert F, Sakmar TP. A mutant rhodopsin photoproduct with a protonated Schiff base displays an active-state conformation: a Fourier-transform infrared spectroscopy study. Biochemistry. 33: 13700-5. PMID 7947779 DOI: 10.1021/Bi00250A021  0.325
1994 Arnis S, Fahmy K, Hofmann KP, Sakmar TP. A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin. The Journal of Biological Chemistry. 269: 23879-81. PMID 7929034  0.344
1993 Fahmy K, Sakmar TP. Light-dependent transducin activation by an ultraviolet-absorbing rhodopsin mutant. Biochemistry. 32: 9165-71. PMID 8396426 DOI: 10.1021/Bi00086A023  0.338
1993 Fahmy K, Sakmar TP. Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group. Biochemistry. 32: 7229-36. PMID 8343512 DOI: 10.1021/Bi00079A020  0.44
1992 Franke RR, Sakmar TP, Graham RM, Khorana HG. Structure and function in rhodopsin. Studies of the interaction between the rhodopsin cytoplasmic domain and transducin. The Journal of Biological Chemistry. 267: 14767-74. PMID 1634520  0.456
1992 Lin SW, Sakmar TP, Franke RR, Khorana HG, Mathies RA. Resonance Raman microprobe spectroscopy of rhodopsin mutants: effect of substitutions in the third transmembrane helix. Biochemistry. 31: 5105-11. PMID 1351402 DOI: 10.1021/Bi00137A003  0.621
1991 Sakmar TP, Franke RR, Khorana HG. The role of the retinylidene Schiff base counterion in rhodopsin in determining wavelength absorbance and Schiff base pKa. Proceedings of the National Academy of Sciences of the United States of America. 88: 3079-83. PMID 2014228  0.424
1990 Franke RR, König B, Sakmar TP, Khorana HG, Hofmann KP. Rhodopsin mutants that bind but fail to activate transducin. Science (New York, N.Y.). 250: 123-5. PMID 2218504  0.524
1989 Sakmar TP, Franke RR, Khorana HG. Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 86: 8309-13. PMID 2573063  0.438
1988 Karnik SS, Sakmar TP, Chen HB, Khorana HG. Cysteine residues 110 and 187 are essential for the formation of correct structure in bovine rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 85: 8459-63. PMID 3186735  0.508
1988 Sakmar TP, Khorana HG. Total synthesis and expression of a gene for the alpha-subunit of bovine rod outer segment guanine nucleotide-binding protein (transducin). Nucleic Acids Research. 16: 6361-72. PMID 3165194 DOI: 10.1093/Nar/16.14.6361  0.506
1988 Franke RR, Sakmar TP, Oprian DD, Khorana HG. A single amino acid substitution in rhodopsin (lysine 248----leucine) prevents activation of transducin. The Journal of Biological Chemistry. 263: 2119-22. PMID 3123487  0.681
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