Klaus Michael Hahn, PhD - Publications

Affiliations: 
Pharmacology University of North Carolina, Chapel Hill, Chapel Hill, NC 

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Marston DJ, Anderson KL, Swift MF, Rougie M, Page C, Hahn KM, Volkmann N, Hanein D. High Rac1 activity is functionally translated into cytosolic structures with unique nanoscale cytoskeletal architecture. Proceedings of the National Academy of Sciences of the United States of America. PMID 30630946 DOI: 10.1073/pnas.1808830116  0.4
2018 Dagliyan O, Krokhotin A, Ozkan-Dagliyan I, Deiters A, Der CJ, Hahn KM, Dokholyan NV. Computational design of chemogenetic and optogenetic split proteins. Nature Communications. 9: 4042. PMID 30279442 DOI: 10.1038/s41467-018-06531-4  0.72
2018 Ma X, Dagliyan O, Hahn KM, Danuser G. Profiling cellular morphodynamics by spatiotemporal spectrum decomposition. Plos Computational Biology. 14: e1006321. PMID 30071020 DOI: 10.1371/journal.pcbi.1006321  0.76
2018 Zhurikhina A, Qi T, Hahn KM, Elston TC, Tsygankov D. EdgeProps: A Computational Platform for Correlative Analysis of Cell Dynamics and Near-Edge Protein Activity. Methods in Molecular Biology (Clifton, N.J.). 1821: 47-56. PMID 30062404 DOI: 10.1007/978-1-4939-8612-5_4  0.56
2018 Tajadura-Ortega V, Garg R, Allen R, Owczarek C, Bright MD, Kean S, Mohd-Noor A, Grigoriadis A, Elston TC, Hahn KM, Ridley AJ. An RNAi screen of Rho signalling networks identifies RhoH as a regulator of Rac1 in prostate cancer cell migration. Bmc Biology. 16: 29. PMID 29510700 DOI: 10.1186/s12915-018-0489-4  0.56
2018 van Haren J, Charafeddine RA, Ettinger A, Wang H, Hahn KM, Wittmann T. Local control of intracellular microtubule dynamics by EB1 photodissociation. Nature Cell Biology. PMID 29379139 DOI: 10.1038/s41556-017-0028-5  0.48
2017 Ye F, Yang C, Kim J, MacNevin CJ, Hahn KM, Park D, Ginsberg MH, Kim C. Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains. The Journal of Biological Chemistry. PMID 28487468 DOI: 10.1074/jbc.C117.787309  0.4
2017 Dagliyan O, Karginov AV, Yagishita S, Gale ME, Wang H, DerMardirossian C, Wells CM, Dokholyan NV, Kasai H, Hahn KM. Engineering Pak1 allosteric switches. Acs Synthetic Biology. PMID 28365983 DOI: 10.1021/acssynbio.6b00359  0.72
2016 Dagliyan O, Tarnawski M, Chu PH, Shirvanyants D, Schlichting I, Dokholyan NV, Hahn KM. Engineering extrinsic disorder to control protein activity in living cells. Science (New York, N.Y.). 354: 1441-1444. PMID 27980211 DOI: 10.1126/science.aah3404  0.72
2016 Wang H, Hahn KM. LOVTRAP: A Versatile Method to Control Protein Function with Light. Current Protocols in Cell Biology. 73: 21.10.1-21.10.14. PMID 27906450 DOI: 10.1002/cpcb.12  0.48
2016 Nguyen TT, Park WS, Park BO, Kim CY, Oh Y, Kim JM, Choi H, Kyung T, Kim CH, Lee G, Hahn KM, Meyer T, Heo WD. PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front. Proceedings of the National Academy of Sciences of the United States of America. PMID 27555588 DOI: 10.1073/pnas.1604720113  0.8
2016 Hodgson L, Spiering D, Sabouri-Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, Hahn KM. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nature Chemical Biology. PMID 27501396 DOI: 10.1038/nchembio.2145  0.76
2016 Wang H, Vilela M, Winkler A, Tarnawski M, Schlichting I, Yumerefendi H, Kuhlman B, Liu R, Danuser G, Hahn KM. LOVTRAP: an optogenetic system for photoinduced protein dissociation. Nature Methods. PMID 27427858 DOI: 10.1038/nmeth.3926  0.76
2016 MacNevin CJ, Toutchkine A, Marston DJ, Hsu CW, Tsygankov D, Li L, Liu B, Qi T, Nguyen DV, Hahn KM. Ratiometric imaging using a single dye enables simultaneous visualization of Rac1 and Cdc42 activation. Journal of the American Chemical Society. PMID 26863024 DOI: 10.1021/jacs.5b09764  0.8
2016 Gentry LR, Karginov AV, Hahn KM, Der CJ. Characterization of an Engineered Src Kinase to Study Src Signaling and Biology. Methods in Molecular Biology (Clifton, N.J.). 1360: 157-67. PMID 26501909 DOI: 10.1007/978-1-4939-3073-9_12  0.56
2016 Gentry LR, Karginov AV, Hahn KM, Der CJ. Characterization of an engineered Src kinase to study Src signaling and biology Methods in Molecular Biology. 1360: 157-167. DOI: 10.1007/978-1-4939-3073-9_12  0.8
2015 Hayashi-Takagi A, Yagishita S, Nakamura M, Shirai F, Wu YI, Loshbaugh AL, Kuhlman B, Hahn KM, Kasai H. Labelling and optical erasure of synaptic memory traces in the motor cortex. Nature. 525: 333-8. PMID 26352471 DOI: 10.1038/nature15257  0.8
2015 Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ. An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A. Cell. 162: 795-807. PMID 26255772 DOI: 10.1016/j.cell.2015.06.045  0.48
2015 Yumerefendi H, Dickinson DJ, Wang H, Zimmerman SP, Bear JE, Goldstein B, Hahn K, Kuhlman B. Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation. Plos One. 10: e0128443. PMID 26083500 DOI: 10.1371/journal.pone.0128443  0.8
2015 Yi JJ, Berrios J, Newbern JM, Snider WD, Philpot BD, Hahn KM, Zylka MJ. An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A Cell. 162: 795-807. DOI: 10.1016/j.cell.2015.06.045  0.8
2014 Helassa N, Garnett JP, Farrant M, Khan F, Pickup JC, Hahn KM, MacNevin CJ, Tarran R, Baines DL. A novel fluorescent sensor protein for detecting changes in airway surface liquid glucose concentration. The Biochemical Journal. 464: 213-20. PMID 25220254 DOI: 10.1042/BJ20141041  0.8
2014 Weitzman M, Hahn KM. Optogenetic approaches to cell migration and beyond. Current Opinion in Cell Biology. 30: 112-20. PMID 25216352 DOI: 10.1016/j.ceb.2014.08.004  0.8
2014 Chu PH, Tsygankov D, Berginski ME, Dagliyan O, Gomez SM, Elston TC, Karginov AV, Hahn KM. Engineered kinase activation reveals unique morphodynamic phenotypes and associated trafficking for Src family isoforms. Proceedings of the National Academy of Sciences of the United States of America. 111: 12420-5. PMID 25118278 DOI: 10.1073/pnas.1404487111  0.8
2014 Tsygankov D, Chu PH, Chen H, Elston TC, Hahn KM. User-friendly tools for quantifying the dynamics of cellular morphology and intracellular protein clusters. Methods in Cell Biology. 123: 409-27. PMID 24974040 DOI: 10.1016/B978-0-12-420138-5.00022-7  0.8
2014 Yi JJ, Wang H, Vilela M, Danuser G, Hahn KM. Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides. Acs Synthetic Biology. 3: 788-95. PMID 24905630 DOI: 10.1021/sb5001356  0.8
2014 Karginov AV, Tsygankov D, Berginski M, Chu PH, Trudeau ED, Yi JJ, Gomez S, Elston TC, Hahn KM. Dissecting motility signaling through activation of specific Src-effector complexes. Nature Chemical Biology. 10: 286-90. PMID 24609359 DOI: 10.1038/nchembio.1477  0.8
2014 Hinde E, Yokomori K, Gaus K, Hahn KM, Gratton E. Fluctuation-based imaging of nuclear Rac1 activation by protein oligomerisation. Scientific Reports. 4: 4219. PMID 24573109 DOI: 10.1038/srep04219  0.8
2014 Tsygankov D, Bilancia CG, Vitriol EA, Hahn KM, Peifer M, Elston TC. CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. The Journal of Cell Biology. 204: 443-60. PMID 24493591 DOI: 10.1083/jcb.201306067  0.8
2014 Khalil BD, Hanna S, Saykali BA, El-Sitt S, Nasrallah A, Marston D, El-Sabban M, Hahn KM, Symons M, El-Sibai M. The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility. Experimental Cell Research. 321: 109-22. PMID 24333506 DOI: 10.1016/j.yexcr.2013.11.023  0.8
2014 Allen RJ, Tsygankov D, Zawistowski JS, Elston TC, Hahn KM. Automated line scan analysis to quantify biosensor activity at the cell edge. Methods (San Diego, Calif.). 66: 162-7. PMID 23994242 DOI: 10.1016/j.ymeth.2013.08.025  0.8
2013 Zawistowski JS, Sabouri-Ghomi M, Danuser G, Hahn KM, Hodgson L. A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells. Plos One. 8: e79877. PMID 24224016 DOI: 10.1371/journal.pone.0079877  0.8
2013 Kummer L, Hsu CW, Dagliyan O, MacNevin C, Kaufholz M, Zimmermann B, Dokholyan NV, Hahn KM, Plückthun A. Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. Chemistry & Biology. 20: 847-56. PMID 23790495 DOI: 10.1016/j.chembiol.2013.04.016  0.8
2013 Rao MV, Chu PH, Hahn KM, Zaidel-Bar R. An optogenetic tool for the activation of endogenous diaphanous-related formins induces thickening of stress fibers without an increase in contractility. Cytoskeleton (Hoboken, N.J.). 70: 394-407. PMID 23677607 DOI: 10.1002/cm.21115  0.8
2013 Konze KD, Ma A, Li F, Barsyte-Lovejoy D, Parton T, Macnevin CJ, Liu F, Gao C, Huang XP, Kuznetsova E, Rougie M, Jiang A, Pattenden SG, Norris JL, James LI, ... ... Hahn KM, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. Acs Chemical Biology. 8: 1324-34. PMID 23614352 DOI: 10.1021/cb400133j  0.8
2013 Dagliyan O, Shirvanyants D, Karginov AV, Ding F, Fee L, Chandrasekaran SN, Freisinger CM, Smolen GA, Huttenlocher A, Hahn KM, Dokholyan NV. Rational design of a ligand-controlled protein conformational switch. Proceedings of the National Academy of Sciences of the United States of America. 110: 6800-4. PMID 23569285 DOI: 10.1073/pnas.1218319110  0.8
2013 Samson T, van Buul JD, Kroon J, Welch C, Bakker EN, Matlung HL, van den Berg TK, Sharek L, Doerschuk C, Hahn K, Burridge K. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. Plos One. 8: e55202. PMID 23372835 DOI: 10.1371/journal.pone.0055202  0.8
2013 MacNevin CJ, Gremyachinskiy D, Hsu CW, Li L, Rougie M, Davis TT, Hahn KM. Environment-sensing merocyanine dyes for live cell imaging applications. Bioconjugate Chemistry. 24: 215-23. PMID 23297747 DOI: 10.1021/bc3005073  0.8
2013 Vilela M, Halidi N, Besson S, Elliott H, Hahn K, Tytell J, Danuser G. Fluctuation analysis of activity biosensor images for the study of information flow in signaling pathways. Methods in Enzymology. 519: 253-76. PMID 23280114 DOI: 10.1016/B978-0-12-405539-1.00009-9  0.8
2013 Hinde E, Digman MA, Hahn KM, Gratton E. Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proceedings of the National Academy of Sciences of the United States of America. 110: 135-40. PMID 23248275 DOI: 10.1073/pnas.1211882110  0.8
2012 Collins C, Guilluy C, Welch C, O'Brien ET, Hahn K, Superfine R, Burridge K, Tzima E. Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Current Biology : Cb. 22: 2087-94. PMID 23084990 DOI: 10.1016/j.cub.2012.08.051  0.8
2012 Galic M, Jeong S, Tsai FC, Joubert LM, Wu YI, Hahn KM, Cui Y, Meyer T. External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nature Cell Biology. 14: 874-81. PMID 22750946 DOI: 10.1038/ncb2533  0.8
2012 Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, ... ... Hahn KM, et al. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nature Neuroscience. 15: 891-6. PMID 22522400 DOI: 10.1038/nn.3094  0.8
2012 Lungu OI, Hallett RA, Choi EJ, Aiken MJ, Hahn KM, Kuhlman B. Designing photoswitchable peptides using the AsLOV2 domain. Chemistry & Biology. 19: 507-17. PMID 22520757 DOI: 10.1016/j.chembiol.2012.02.006  0.8
2012 Hinde E, Digman MA, Welch C, Hahn KM, Gratton E. Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microscopy Research and Technique. 75: 271-81. PMID 21858900 DOI: 10.1002/jemt.21054  0.8
2011 Karginov AV, Hahn KM. Allosteric activation of kinases: design and application of RapR kinases. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 14.13.. PMID 22161545 DOI: 10.1002/0471143030.cb1413s53  0.8
2011 Welch CM, Elliott H, Danuser G, Hahn KM. Imaging the coordination of multiple signalling activities in living cells. Nature Reviews. Molecular Cell Biology. 12: 749-56. PMID 22016058 DOI: 10.1038/nrm3212  0.8
2011 Jha RK, Wu YI, Zawistowski JS, MacNevin C, Hahn KM, Kuhlman B. Redesign of the PAK1 autoinhibitory domain for enhanced stability and affinity in biosensor applications. Journal of Molecular Biology. 413: 513-22. PMID 21888918 DOI: 10.1016/j.jmb.2011.08.022  0.8
2011 Berginski ME, Vitriol EA, Hahn KM, Gomez SM. High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. Plos One. 6: e22025. PMID 21779367 DOI: 10.1371/journal.pone.0022025  0.8
2011 Gulyani A, Vitriol E, Allen R, Wu J, Gremyachinskiy D, Lewis S, Dewar B, Graves LM, Kay BK, Kuhlman B, Elston T, Hahn KM. A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nature Chemical Biology. 7: 437-44. PMID 21666688 DOI: 10.1038/nchembio.585  0.8
2011 Shadpour H, Zawistowski JS, Herman A, Hahn K, Allbritton NL. Patterning pallet arrays for cell selection based on high-resolution measurements of fluorescent biosensors. Analytica Chimica Acta. 696: 101-7. PMID 21621038 DOI: 10.1016/j.aca.2011.04.012  0.8
2011 Wu YI, Wang X, He L, Montell D, Hahn KM. Spatiotemporal control of small GTPases with light using the LOV domain. Methods in Enzymology. 497: 393-407. PMID 21601095 DOI: 10.1016/B978-0-12-385075-1.00016-0  0.8
2011 Helfand BT, Mendez MG, Murthy SN, Shumaker DK, Grin B, Mahammad S, Aebi U, Wedig T, Wu YI, Hahn KM, Inagaki M, Herrmann H, Goldman RD. Vimentin organization modulates the formation of lamellipodia. Molecular Biology of the Cell. 22: 1274-89. PMID 21346197 DOI: 10.1091/mbc.E10-08-0699  0.8
2011 Karginov AV, Zou Y, Shirvanyants D, Kota P, Dokholyan NV, Young DD, Hahn KM, Deiters A. Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP. Journal of the American Chemical Society. 133: 420-3. PMID 21162531 DOI: 10.1021/ja109630v  0.8
2011 Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, Huttenlocher A. Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish Developmental Cell. 21: 384. DOI: 10.1016/j.devcel.2011.08.006  0.8
2010 Hahn KM, Kuhlman B. Hold me tightly LOV. Nature Methods. 7: 595, 597. PMID 20676078 DOI: 10.1038/nmeth0810-595  0.8
2010 Karginov AV, Ding F, Kota P, Dokholyan NV, Hahn KM. Engineered allosteric activation of kinases in living cells. Nature Biotechnology. 28: 743-7. PMID 20581846 DOI: 10.1038/nbt.1639  0.8
2010 Wang X, He L, Wu YI, Hahn KM, Montell DJ. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nature Cell Biology. 12: 591-7. PMID 20473296 DOI: 10.1038/ncb2061  0.8
2010 Samson T, Welch C, Monaghan-Benson E, Hahn KM, Burridge K. Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Molecular Biology of the Cell. 21: 1629-42. PMID 20237158 DOI: 10.1091/mbc.E09-09-0809  0.8
2010 Hodgson L, Shen F, Hahn K. Biosensors for characterizing the dynamics of rho family GTPases in living cells. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 14.11.1-26. PMID 20235099 DOI: 10.1002/0471143030.cb1411s46  0.8
2010 Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, Huttenlocher A. Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Developmental Cell. 18: 226-36. PMID 20159593 DOI: 10.1016/j.devcel.2009.11.015  0.8
2010 Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, Touret N, Hahn KM, Grinstein S. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. The Journal of Cell Biology. 188: 547-63. PMID 20156964 DOI: 10.1083/jcb.200908086  0.8
2010 Koivusalo M, Welch C, Hayashi H, Scott CC, Kim M, Alexander T, Touret N, Hahn KM, Grinstein S. Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling (Journal of Cell Biology (2010) 188, (547-563)) Journal of Cell Biology. 189: 385. DOI: 10.1083/jcb.20090808620100331c  0.8
2009 Wu YI, Frey D, Lungu OI, Jaehrig A, Schlichting I, Kuhlman B, Hahn KM. A genetically encoded photoactivatable Rac controls the motility of living cells. Nature. 461: 104-8. PMID 19693014 DOI: 10.1038/nature08241  0.8
2009 Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G. Coordination of Rho GTPase activities during cell protrusion. Nature. 461: 99-103. PMID 19693013 DOI: 10.1038/nature08242  0.8
2009 Manukyan M, Nalbant P, Luxen S, Hahn KM, Knaus UG. RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. Journal of Immunology (Baltimore, Md. : 1950). 182: 3522-9. PMID 19265130 DOI: 10.4049/jimmunol.0802280  0.8
2009 Su L, Pertz O, Mikawa M, Hahn K, Parsons SJ. p190RhoGAP negatively regulates Rho activity at the cleavage furrow of mitotic cells. Experimental Cell Research. 315: 1347-59. PMID 19254711 DOI: 10.1016/j.yexcr.2009.02.014  0.8
2008 Jacobson K, Rajfur Z, Vitriol E, Hahn K. Chromophore-assisted laser inactivation in cell biology Trends in Cell Biology. 18: 443-450. PMID 18706812 DOI: 10.1016/j.tcb.2008.07.001  0.8
2008 Sabouri-Ghomi M, Wu Y, Hahn K, Danuser G. Visualizing and quantifying adhesive signals. Current Opinion in Cell Biology. 20: 541-50. PMID 18586481 DOI: 10.1016/j.ceb.2008.05.004  0.8
2008 Shen F, Hodgson L, Price JH, Hahn KM. Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 73: 658-66. PMID 18395817 DOI: 10.1002/cyto.a.20558  0.8
2008 El-Sibai M, Pertz O, Pang H, Yip SC, Lorenz M, Symons M, Condeelis JS, Hahn KM, Backer JM. RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Experimental Cell Research. 314: 1540-52. PMID 18316075 DOI: 10.1016/j.yexcr.2008.01.016  0.8
2008 Hodgson L, Pertz O, Hahn KM. Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods in Cell Biology. 85: 63-81. PMID 18155459 DOI: 10.1016/S0091-679X(08)85004-2  0.8
2008 Garrett SC, Hodgson L, Rybin A, Toutchkine A, Hahn KM, Lawrence DS, Bresnick AR. A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry. 47: 986-96. PMID 18154362 DOI: 10.1021/bi7021624  0.8
2008 Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD. Spatial and temporal regulation of focal adhesion kinase activity in living cells. Molecular and Cellular Biology. 28: 201-14. PMID 17967873 DOI: 10.1128/MCB.01324-07  0.8
2008 Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Molecular Carcinogenesis. 47: 326-37. PMID 17932950 DOI: 10.1002/mc.20389  0.8
2007 Frantz C, Karydis A, Nalbant P, Hahn KM, Barber DL. Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. The Journal of Cell Biology. 179: 403-10. PMID 17984318 DOI: 10.1083/jcb.200704169  0.8
2007 Toutchkine A, Han WG, Ullmann M, Liu T, Bashford D, Noodleman L, Hahn KM. Experimental and DFT studies: novel structural modifications greatly enhance the solvent sensitivity of live cell imaging dyes. The Journal of Physical Chemistry. A. 111: 10849-60. PMID 17918807 DOI: 10.1021/jp073197r  0.8
2007 El-Sibai M, Nalbant P, Pang H, Flinn RJ, Sarmiento C, Macaluso F, Cammer M, Condeelis JS, Hahn KM, Backer JM. Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. Journal of Cell Science. 120: 3465-74. PMID 17855387 DOI: 10.1242/jcs.005942  0.8
2007 Hodgson L, Chan EW, Hahn KM, Yousaf MN. Combining surface chemistry with a FRET-based biosensor to study the dynamics of RhoA GTPase activation in cells on patterned substrates. Journal of the American Chemical Society. 129: 9264-5. PMID 17625860 DOI: 10.1021/ja072900m  0.8
2007 Malone MH, Sciaky N, Stalheim L, Hahn KM, Linney E, Johnson GL. Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. Bmc Biotechnology. 7: 40. PMID 17623073 DOI: 10.1186/1472-6750-7-40  0.8
2007 Toutchkine A, Nguyen DV, Hahn KM. Merocyanine dyes with improved photostability. Organic Letters. 9: 2775-7. PMID 17583344 DOI: 10.1021/ol070780h  0.8
2007 Toutchkine A, Nguyen DV, Hahn KM. Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging. Bioconjugate Chemistry. 18: 1344-8. PMID 17542551 DOI: 10.1021/bc060376n  0.8
2007 Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Developmental Cell. 12: 699-712. PMID 17488622 DOI: 10.1016/j.devcel.2007.03.014  0.8
2007 Birkenfeld J, Nalbant P, Bohl BP, Pertz O, Hahn KM, Bokoch GM. GEF-H1 Modulates Localized RhoA Activation during Cytokinesis under the Control of Mitotic Kinases (DOI:10.1016/j.devcel.2007.03.014) Developmental Cell. 12: 1007. DOI: 10.1016/j.devcel.2007.05.013  0.8
2006 Shen F, Hodgson L, Hahn K. Digital autofocus methods for automated microscopy. Methods in Enzymology. 414: 620-32. PMID 17110214 DOI: 10.1016/S0076-6879(06)14032-X  0.8
2006 Wang YL, Hahn KM, Murphy RF, Horwitz AF. From imaging to understanding: Frontiers in Live Cell Imaging, Bethesda, MD, April 19-21, 2006. The Journal of Cell Biology. 174: 481-4. PMID 16908666 DOI: 10.1083/jcb.200607097  0.8
2006 Shen F, Hodgson L, Rabinovich A, Pertz O, Hahn K, Price JH. Functional proteometrics for cell migration. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 563-72. PMID 16752422 DOI: 10.1002/cyto.a.20283  0.8
2006 Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature. 440: 1069-72. PMID 16547516 DOI: 10.1038/nature04665  0.8
2006 Wong K, Pertz O, Hahn K, Bourne H. Neutrophil polarization: spatiotemporal dynamics of RhoA activity support a self-organizing mechanism. Proceedings of the National Academy of Sciences of the United States of America. 103: 3639-44. PMID 16537448 DOI: 10.1073/pnas.0600092103  0.8
2006 Nakamura K, Uhlik MT, Johnson NL, Hahn KM, Johnson GL. PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Molecular and Cellular Biology. 26: 2065-79. PMID 16507987 DOI: 10.1128/MCB.26.6.2065-2079.2006  0.8
2006 Hodgson L, Nalbant P, Shen F, Hahn K. Imaging and photobleach correction of Mero-CBD, sensor of endogenous Cdc42 activation. Methods in Enzymology. 406: 140-56. PMID 16472656 DOI: 10.1016/S0076-6879(06)06012-5  0.8
2006 Euliss LE, Welch CM, Maynor BW, Rolland JP, Denison GM, Gratton SE, Park JY, Pandya AA, Enlow EL, Juliano RL, Hahn KM, DeSimone JM. Monodisperse nanocarriers: Novel fabrication of polymeric nanoparticles for bio-nanotechnology Proceedings of Spie - the International Society For Optical Engineering. 6153. DOI: 10.1117/12.656617  0.8
2005 Subauste MC, Nalbant P, Adamson ED, Hahn KM. Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. The Journal of Biological Chemistry. 280: 5676-81. PMID 15579911 DOI: 10.1074/jbc.M405561200  0.8
2004 Nalbant P, Hodgson L, Kraynov V, Toutchkine A, Hahn KM. Activation of endogenous Cdc42 visualized in living cells. Science (New York, N.Y.). 305: 1615-9. PMID 15361624 DOI: 10.1126/science.1100367  0.8
2004 Subauste MC, Pertz O, Adamson ED, Turner CE, Junger S, Hahn KM. Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. The Journal of Cell Biology. 165: 371-81. PMID 15138291 DOI: 10.1083/jcb.200308011  0.8
2004 Pertz O, Hahn KM. Designing biosensors for Rho family proteins--deciphering the dynamics of Rho family GTPase activation in living cells. Journal of Cell Science. 117: 1313-8. PMID 15020671 DOI: 10.1242/jcs.01117  0.8
2004 Liu T, Han WG, Himo F, Ullmann GM, Bashford D, Toutchkine A, Hahn KM, Noodleman L. Density Functional Vertical Self-Consistent Reaction Field Theory for Solvatochromism Studies of Solvent-Sensitive Dyes Journal of Physical Chemistry A. 108: 3545-3555. DOI: 10.1021/jp031062p  0.8
2004 Tan X, Nalbant P, Toutchkine A, Hu D, Vorpagel ER, Hahn KM, Lu PP. Single-Molecule Study of Protein-Protein Interaction Dynamics in a Cell Signaling System Journal of Physical Chemistry B. 108: 737-744.  0.8
2003 Han WG, Liu T, Himo F, Toutchkine A, Bashford D, Hahn KM, Noodleman L. A theoretical study of the UV/visible absorption and emission solvatochromic properties of solvent-sensitive dyes. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 4: 1084-94. PMID 14596006 DOI: 10.1002/cphc.200300801  0.8
2003 Hahn K. Monitoring signaling processes in living cells using biosensors Science's Stke : Signal Transduction Knowledge Environment. 2003: tr5. PMID 14570979  0.8
2003 Toutchkine A, Kraynov V, Hahn K. Solvent-sensitive dyes to report protein conformational changes in living cells Journal of the American Chemical Society. 125: 4132-4145. PMID 12670235 DOI: 10.1021/ja0290882  0.8
2003 Gaits F, Hahn K. Shedding light on cell signaling: interpretation of FRET biosensors. Science's Stke : Signal Transduction Knowledge Environment. 2003: PE3. PMID 12527820 DOI: 10.1126/stke.2003.165.pe3  0.8
2002 Price JH, Goodacre A, Hahn K, Hodgson L, Hunter EA, Krajewski S, Murphy RF, Rabinovich A, Reed JC, Heynen S. Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools. Journal of Cellular Biochemistry. Supplement. 39: 194-210. PMID 12552619 DOI: 10.1002/jcb.10448  0.8
2002 Gardiner EM, Pestonjamasp KN, Bohl BP, Chamberlain C, Hahn KM, Bokoch GM. Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Current Biology : Cb. 12: 2029-34. PMID 12477392 DOI: 10.1016/S0960-9822(02)01334-9  0.8
2002 Tu SS, Wu WJ, Yang W, Nolbant P, Hahn K, Cerione RA. Antiapoptotic Cdc42 mutants are potent activators of cellular transformation. Biochemistry. 41: 12350-8. PMID 12369824 DOI: 10.1021/bi026167h  0.8
2002 Katsumi A, Milanini J, Kiosses WB, del Pozo MA, Kaunas R, Chien S, Hahn KM, Schwartz MA. Effects of cell tension on the small GTPase Rac. The Journal of Cell Biology. 158: 153-64. PMID 12105187 DOI: 10.1083/jcb.200201105  0.8
2002 Toutchkine A, Nalbant P, Hahn KM. Facile synthesis of thiol-reactive Cy3 and Cy5 derivatives with enhanced water solubility. Bioconjugate Chemistry. 13: 387-91. PMID 12009924 DOI: 10.1021/bc015558q  0.8
2002 Nishimura N, Plutner H, Hahn K, Balch WE. The delta subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface. Proceedings of the National Academy of Sciences of the United States of America. 99: 6755-60. PMID 11997454 DOI: 10.1073/pnas.092150699  0.8
2002 Hahn K, Toutchkine A. Live-cell fluorescent biosensors for activated signaling proteins Current Opinion in Cell Biology. 14: 167-172. PMID 11891115 DOI: 10.1016/S0955-0674(02)00313-7  0.8
2002 Del Pozo MA, Kiosses WB, Alderson NB, Meller N, Hahn KM, Schwartz MA. Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nature Cell Biology. 4: 232-9. PMID 11862216 DOI: 10.1038/ncb759  0.8
2001 Kiosses WB, Hahn KM, Giannelli G, Quaranta V. Characterization of morphological and cytoskeletal changes in MCF10A breast epithelial cells plated on laminin-5: comparison with breast cancer cell line MCF7. Cell Communication & Adhesion. 8: 29-44. PMID 11775027  0.8
2001 Weiss TS, Chamberlain CE, Takeda T, Lin P, Hahn KM, Farquhar MG. Galpha i3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer of green fluorescent protein fusion proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 14961-6. PMID 11752444 DOI: 10.1073/pnas.261572098  0.8
2001 Subauste MC, List B, Guan X, Hahn KM, Lerner R, Gilula NB. A catalytic antibody produces fluorescent tracers of gap junction communication in living cells. The Journal of Biological Chemistry. 276: 49164-8. PMID 11606573 DOI: 10.1074/jbc.M105700200  0.8
2000 Chamberlain C, Hahn KM. Watching proteins in the wild: fluorescence methods to study protein dynamics in living cells. Traffic (Copenhagen, Denmark). 1: 755-62. PMID 11208065  0.8
2000 Chamberlain CE, Kraynov VS, Hahn KM. Imaging spatiotemporal dynamics of Rac activation in vivo with FLAIR. Methods in Enzymology. 325: 389-400. PMID 11036621  0.8
2000 Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S, Hahn KM. Localized Rac activation dynamics visualized in living cells. Science (New York, N.Y.). 290: 333-7. PMID 11030651 DOI: 10.1126/science.290.5490.333  0.8
2000 Subauste MC, Von Herrath M, Benard V, Chamberlain CE, Chuang TH, Chu K, Bokoch GM, Hahn KM. Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. The Journal of Biological Chemistry. 275: 9725-33. PMID 10734125 DOI: 10.1074/jbc.275.13.9725  0.8
2000 Bark SJ, Hahn KM. Fluorescent indicators of peptide cleavage in the trafficking compartments of living cells: peptides site-specifically labeled with two dyes. Methods (San Diego, Calif.). 20: 429-35. PMID 10720464 DOI: 10.1006/meth.2000.0956  0.8
2000 Bark SJ, Schmid S, Hahn KM. A highly efficient method for site-specific modification of unprotected peptides after chemical synthesis Journal of the American Chemical Society. 122: X. DOI: 10.1021/ja000217t  0.8
1998 Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I. Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infection and Immunity. 66: 1755-8. PMID 9529109  0.8
1997 Chuang TH, Hahn KM, Lee JD, Danley DE, Bokoch GM. The small GTPase Cdc42 initiates an apoptotic signaling pathway in Jurkat T lymphocytes. Molecular Biology of the Cell. 8: 1687-98. PMID 9307966  0.8
1996 Shelby RD, Hahn KM, Sullivan KF. Dynamic elastic behavior of alpha-satellite DNA domains visualized in situ in living human cells. The Journal of Cell Biology. 135: 545-57. PMID 8909532 DOI: 10.1083/jcb.135.3.545  0.8
1996 Waters JB, Oldstone MB, Hahn KM. Changes in the cytoplasmic structure of CTLs during target cell recognition and killing. Journal of Immunology (Baltimore, Md. : 1950). 157: 3396-403. PMID 8871637  0.8
1996 Cornish VW, Hahn KM, Schultz PG. Site-specific protein modification using a ketone handle Journal of the American Chemical Society. 118: 8150-8151. DOI: 10.1021/ja961216x  0.8
1995 Southwick PL, Hahn KM, Chao J, Perry PL, Wagman AS, Wagner M, Waggoner AS. A long-wavelength biolabeling reagent based on the oxonol fluorophore. Journal of Fluorescence. 5: 231-5. PMID 24226669 DOI: 10.1007/BF00727544  0.8
1995 Bark IC, Hahn KM, Ryabinin AE, Wilson MC. Differential expression of SNAP-25 protein isoforms during divergent vesicle fusion events of neural development. Proceedings of the National Academy of Sciences of the United States of America. 92: 1510-4. PMID 7878010 DOI: 10.1073/pnas.92.5.1510  0.8
1995 Lewicki H, Tishon A, Borrow P, Evans CF, Gairin JE, Hahn KM, Jewell DA, Wilson IA, Oldstone MB. CTL escape viral variants. I. Generation and molecular characterization. Virology. 210: 29-40. PMID 7793078 DOI: 10.1006/viro.1995.1314  0.8
1995 Giuliano KA, Post PL, Hahn KM, Taylor DL. Fluorescent protein biosensors: measurement of molecular dynamics in living cells. Annual Review of Biophysics and Biomolecular Structure. 24: 405-34. PMID 7663122 DOI: 10.1146/annurev.bb.24.060195.002201  0.8
1993 Hahn KM, Conrad PA, Chao JC, Taylor DL, Waggoner AS. A photocross-linking fluorescent indicator of mitochondrial membrane potential. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 41: 631-4. PMID 8450203  0.8
1992 Hahn KM, Hastie SB, Sundberg RJ. Synthesis and evaluation of 2-diazo-3,3,3-trifluopropanoyl derivatives of colchicine and podophyllotoxin as photoaffinity labels: reactivity, photochemistry, and tubulin binding. Photochemistry and Photobiology. 55: 17-27. PMID 1603847  0.8
1991 Hahn KM, Southwick PL. A stable diazo photoaffinity label with high absorptivity and effective photoactivation beyond 300 nm. Analytical Biochemistry. 196: 271-8. PMID 1776676 DOI: 10.1016/0003-2697(91)90465-6  0.8
1991 Hahn KM, Humphreys WG, Helms AM, Hastie SB, Macdonald TL. Structural requirements for the binding of colchicine analogs to tubulin: the role of the C-10 substituent Bioorganic and Medicinal Chemistry Letters. 1: 471-476. DOI: 10.1016/S0960-894X(01)81108-2  0.8
1990 Hahn KM, Waggoner AS, Taylor DL. A calcium-sensitive fluorescent analog of calmodulin based on a novel calmodulin-binding fluorophore. The Journal of Biological Chemistry. 265: 20335-45. PMID 2173702  0.8
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