Year |
Citation |
Score |
2022 |
Mustaly-Kalimi S, Gallegos W, Marr RA, Gilman-Sachs A, Peterson DA, Sekler I, Stutzmann GE. Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 119: e2211999119. PMID 36442130 DOI: 10.1073/pnas.2211999119 |
0.357 |
|
2020 |
Maigler K, Buhr T, Park C, Miller S, Kozlowski DA, Marr R. Assessment of the effects of altered amyloid-beta clearance on behavior following repeat closed-head brain injury in APP humanized mice. Journal of Neurotrauma. PMID 33176547 DOI: 10.1089/neu.2020.6989 |
0.743 |
|
2020 |
Schrank S, McDaid J, Briggs CA, Mustaly-Kalimi S, Brinks D, Houcek A, Singer O, Bottero V, Marr RA, Stutzmann GE. Human-Induced Neurons from Presenilin 1 Mutant Patients Model Aspects of Alzheimer's Disease Pathology. International Journal of Molecular Sciences. 21. PMID 32033164 DOI: 10.3390/Ijms21031030 |
0.462 |
|
2018 |
Chang JL, Hinrich AJ, Roman B, Norrbom M, Rigo F, Marr RA, Norstrom EM, Hastings ML. Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29628304 DOI: 10.1016/J.Ymthe.2018.02.029 |
0.523 |
|
2018 |
Lim PH, Wert SL, Tunc-Ozcan E, Marr R, Ferreira A, Redei EE. Premature hippocampus-dependent memory decline in middle-aged females of a genetic rat model of depression. Behavioural Brain Research. PMID 29490235 DOI: 10.1016/J.Bbr.2018.02.030 |
0.354 |
|
2018 |
Schrank S, Briggs C, McDaid J, Maigler K, Marr R, Stutzmann GE. P3-074: Human Induced Neurons Model Hallmarks Of Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.1430 |
0.349 |
|
2016 |
Hinrich AJ, Jodelka FM, Chang JL, Brutman D, Bruno AM, Briggs CA, James BD, Stutzmann GE, Bennett DA, Miller SA, Rigo F, Marr RA, Hastings ML. Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides. Embo Molecular Medicine. PMID 26902204 DOI: 10.15252/Emmm.201505846 |
0.514 |
|
2015 |
Bonds JA, Kuttner-Hirshler Y, Bartolotti N, Tobin MK, Pizzi M, Marr R, Lazarov O. Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. Plos One. 10: e0131266. PMID 26098332 DOI: 10.1371/Journal.Pone.0131266 |
0.309 |
|
2014 |
Marr RA. Editorial on, "Amyloid-beta clearance in Alzheimer's disease". Frontiers in Aging Neuroscience. 6: 310. PMID 25477816 DOI: 10.3389/Fnagi.2014.00310 |
0.415 |
|
2014 |
Philibert KD, Marr RA, Norstrom EM, Glucksman MJ. Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches. Frontiers in Aging Neuroscience. 6: 265. PMID 25346686 DOI: 10.3389/Fnagi.2014.00265 |
0.517 |
|
2014 |
Marr RA, Hafez DM. Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance. Frontiers in Aging Neuroscience. 6: 187. PMID 25165447 DOI: 10.3389/Fnagi.2014.00187 |
0.781 |
|
2013 |
Lazarov O, Marr RA. Of mice and men: neurogenesis, cognition and Alzheimer's disease. Frontiers in Aging Neuroscience. 5: 43. PMID 23986699 DOI: 10.3389/Fnagi.2013.00043 |
0.38 |
|
2012 |
Hafez DM, Huang JY, Richardson JC, Masliah E, Peterson DA, Marr RA. F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice. Neuroscience. 223: 465-72. PMID 22863679 DOI: 10.1016/J.Neuroscience.2012.07.038 |
0.778 |
|
2012 |
Huang JY, Hafez DM, James BD, Bennett DA, Marr RA. Altered NEP2 expression and activity in mild cognitive impairment and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 433-41. PMID 22008264 DOI: 10.3233/Jad-2011-111307 |
0.759 |
|
2012 |
Bruno AM, Huang JY, Bennett DA, Marr RA, Hastings ML, Stutzmann GE. Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease. Neurobiology of Aging. 33: 1001.e1-6. PMID 21531043 DOI: 10.1016/J.Neurobiolaging.2011.03.011 |
0.582 |
|
2011 |
Spencer B, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E. Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease. Plos One. 6: e16575. PMID 21304989 DOI: 10.1371/Journal.Pone.0016575 |
0.652 |
|
2011 |
Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E, Marr RA. Neprilysin-2 is an important β-amyloid degrading enzyme. The American Journal of Pathology. 178: 306-12. PMID 21224067 DOI: 10.1016/J.Ajpath.2010.11.012 |
0.783 |
|
2011 |
Hanson LR, Hafez D, Svitak AL, Burns RB, Li X, Frey WH, Marr RA. Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice. Journal of Molecular Neuroscience : Mn. 43: 424-7. PMID 20941644 DOI: 10.1007/S12031-010-9460-8 |
0.793 |
|
2011 |
Lazarov O, Gadadhar A, Marr R. P3-191: Alzheimer's disease and neurogenesis: Familial(r) signaling, new roles Alzheimer's & Dementia. 7: S577-S578. DOI: 10.1016/J.Jalz.2011.05.1632 |
0.311 |
|
2010 |
Marr RA, Spencer BJ. NEP-like endopeptidases and Alzheimer's disease [corrected]. Current Alzheimer Research. 7: 223-9. PMID 20088804 DOI: 10.2174/156720510791050849 |
0.462 |
|
2010 |
Lazarov O, Marr RA. Neurogenesis and Alzheimer's disease: at the crossroads. Experimental Neurology. 223: 267-81. PMID 19699201 DOI: 10.1016/J.Expneurol.2009.08.009 |
0.426 |
|
2010 |
Marr RA, Hafez D, Huang J, Huynh A, Bruno A, Valtierra S, Rockenstein E, DesGroseillers L, Lu B, Frey W, Hanson L, Bennett D, Masliah E. O2-03-06: Nep-like proteases are important Aß degrading enzymes Alzheimer's & Dementia. 6: S101-S102. DOI: 10.1016/J.Jalz.2010.05.319 |
0.707 |
|
2009 |
Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1115-25. PMID 19176820 DOI: 10.1523/Jneurosci.4220-08.2009 |
0.556 |
|
2008 |
Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. Bmc Neuroscience. 9: 109. PMID 19014502 DOI: 10.1186/1471-2202-9-109 |
0.656 |
|
2008 |
Huang JY, Bruno AM, Patel CA, Huynh AM, Philibert KD, Glucksman MJ, Marr RA. Human membrane metallo-endopeptidase-like protein degrades both beta-amyloid 42 and beta-amyloid 40. Neuroscience. 155: 258-62. PMID 18571334 DOI: 10.1016/J.Neuroscience.2008.05.006 |
0.604 |
|
2008 |
El-Amouri SS, Zhu H, Yu J, Marr R, Verma IM, Kindy MS. Neprilysin: an enzyme candidate to slow the progression of Alzheimer's disease. The American Journal of Pathology. 172: 1342-54. PMID 18403590 DOI: 10.2353/Ajpath.2008.070620 |
0.658 |
|
2008 |
Marr RA, Huang J, Huynh A, Bruno A, Patel C, Lu B, DesGroseillers L, Bennett D, Masliah E. O2-03-02: NEP2 is an important beta-amyloid degrading enzyme Alzheimer's & Dementia. 4: T135-T136. DOI: 10.1016/J.Jalz.2008.05.323 |
0.567 |
|
2008 |
Gadadhar A, Marr R, Lazarov O. P3-382: The role Of presenilin-1 in adult neurogenesis: Implications for Alzheimer's disease Alzheimer's & Dementia. 4: T633-T633. DOI: 10.1016/J.Jalz.2008.05.1952 |
0.355 |
|
2007 |
Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opinion On Biological Therapy. 7: 1853-67. PMID 18034651 DOI: 10.1517/14712598.7.12.1853 |
0.509 |
|
2006 |
Singer O, Marr RA, Rockenstein E, Crow L, Gage FH, Verma IM, Masliah E. 81. Hippocampal Gene Knockdown of BACE1 by Lentiviral Gene Transfer of siRNA Reduces Amyloid Pathology and Improves Memory Performance in APP Transgenic Mice Molecular Therapy. 13: S34. DOI: 10.1016/J.Ymthe.2006.08.099 |
0.689 |
|
2006 |
Mustaly SH, Garstka M, Kapecki N, Beaman KD, Gilman-Sachs A, McDaid J, Schrank S, Marr R, Stutzmann GE. P1-216: LYSOSOME-AUTOPHAGOSOME DEFECTS MEDIATE PROTEINOPATHY AND SYNAPTIC PATHOPHYSIOLOGY IN EARLY STAGES OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P361-P361. DOI: 10.1016/J.Jalz.2018.06.221 |
0.329 |
|
2005 |
Hovatta I, Tennant RS, Helton R, Marr RA, Singer O, Redwine JM, Ellison JA, Schadt EE, Verma IM, Lockhart DJ, Barlow C. Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature. 438: 662-6. PMID 16244648 DOI: 10.1038/Nature04250 |
0.47 |
|
2005 |
Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience. 8: 1343-9. PMID 16136043 DOI: 10.1038/Nn1531 |
0.661 |
|
2005 |
Dodart JC, Marr RA, Koistinaho M, Gregersen BM, Malkani S, Verma IM, Paul SM. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 1211-6. PMID 15657137 DOI: 10.1073/Pnas.0409072102 |
0.67 |
|
2005 |
Singer O, Marr RA, Rockenstein E, Crews L, Gage FH, Verma IM, Masliah E. 56. Amelioration of Neurodegenerative and Neuropathological Alterations in a Transgenic Model of Alzheimer's Disease: Targeting BACE1 with Small Interfering RNAs Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.084 |
0.689 |
|
2004 |
Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Therapy. 11: 1713-23. PMID 15483670 DOI: 10.1038/Sj.Gt.3302349 |
0.408 |
|
2004 |
Kankkonen HM, Vähäkangas E, Marr RA, Pakkanen T, Laurema A, Leppänen P, Jalkanen J, Verma IM, Ylä-Herttuala S. Long-term lowering of plasma cholesterol levels in LDL-receptor-deficient WHHL rabbits by gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 548-56. PMID 15093185 DOI: 10.1016/J.Ymthe.2004.01.015 |
0.452 |
|
2004 |
Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. Journal of Molecular Neuroscience : Mn. 22: 5-11. PMID 14742905 DOI: 10.1385/Jmn:22:1-2:5 |
0.631 |
|
2004 |
Marr RA, Rockenstien E, Kindy MS, Hersh LB, Gage FH, Masliah E, Verma IM. 525. Therapy for Alzheimer's disease by neprilysin gene transfer Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.470 |
0.672 |
|
2003 |
Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1992-6. PMID 12657655 DOI: 10.1523/Jneurosci.23-06-01992.2003 |
0.684 |
|
1999 |
Marr RA, Hitt M, Gauldie J, Muller WJ, Graham FL. A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity. Cancer Gene Therapy. 6: 465-74. PMID 10505857 DOI: 10.1038/Sj.Cgt.7700068 |
0.351 |
|
1998 |
Lei XF, Ohkawara Y, Stämpfli MR, Mastruzzo C, Marr RA, Snider D, Xing Z, Jordana M. Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice. The Journal of Clinical Investigation. 101: 1342-53. PMID 9502776 DOI: 10.1172/Jci1662 |
0.383 |
|
1998 |
Marr RA, Hitt M, Muller WJ, Gauldie J, Graham FL. Tumour therapy in mice using adenovirus vectors expressing human TNFa. International Journal of Oncology. 12: 509-15. PMID 9472086 DOI: 10.3892/Ijo.12.3.509 |
0.416 |
|
1997 |
Marr RA, Addison CL, Snider D, Muller WJ, Gauldie J, Graham FL. Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNF alpha. Gene Therapy. 4: 1181-8. PMID 9425441 DOI: 10.1038/Sj.Gt.3300528 |
0.378 |
|
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