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Steve A. N. Goldstein, M.D., Ph.D. - Publications

Affiliations: 
1993-2004 Yale University, New Haven, CT 
 2004-2011 University of Chicago, Chicago, IL 
 2011-2017 Brandeis University, Waltham, MA, United States 
 2017-2019 Loyola University Stritch School of Medicine, Maywood, IL, United States 
 2019- University of California, Irvine, Irvine, CA 
Area:
General Biophysics, Pediatrics, Cardiology
Website:
https://www.faculty.uci.edu/profile.cfm?faculty_id=6576
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76 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kamiya N, Atsawasuwan P, Joiner DM, Waldorff EI, Goldstein S, Yamauchi M, Mishina Y. Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass. Bone. 115513. PMID 32603910 DOI: 10.1016/J.Bone.2020.115513  0.377
2020 Zhang H, Zhang Y, Terajima M, Romanowicz G, Liu Y, Omi M, Bigelow E, Joiner DM, Waldorff EI, Zhu P, Raghavan M, Lynch M, Kamiya N, Zhang R, Jepsen KJ, ... Goldstein S, et al. Loss of BMP signaling mediated by BMPR1A in osteoblasts leads to differential bone phenotypes in mice depending on anatomical location of the bones. Bone. 115402. PMID 32360900 DOI: 10.1016/J.Bone.2020.115402  0.37
2020 Zhao R, Dai H, Mendelman N, Chill JH, Goldstein SA. Tethered Peptide Neurotoxins Facilitate Biophysical Study and Reveal Two Voltage-dependent Blocking Mechanisms for SAK1 Toxins in the K+ Channel Pore Biophysical Journal. 118: 110a-111a. DOI: 10.1016/j.bpj.2019.11.752  0.481
2019 Bayliss DA, Czirják G, Enyedi P, Goldstein SA, Lesage F, Minor, Jr. DL, Plant LD, Sepúlveda F, Winn BT. Two P domain potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f79/2019.4  0.554
2018 Goldstein SA. Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme. Embo Molecular Medicine. 9: 399-402. PMID 28258154 DOI: 10.15252/emmm.201607479  0.457
2017 Zhao R, Dai H, Mendelman N, Cuello LG, Chill JH, Goldstein SA. Identification of Novel and Natural High Affinity Peptide Inhibitors of KcsA by Phage-Display Reveals an Unexpected Mechanism of Pore Blockade Biophysical Journal. 112: 173a. DOI: 10.1016/J.Bpj.2016.11.956  0.548
2017 Xiong D, Li T, Plant LD, Goldstein SA. KCNE1-Dependent Sumoylation of K V 7.1 Subunits Determines the Voltage-Dependence of Cardiac I Ks Channels Biophysical Journal. 112: 163a. DOI: 10.1016/J.BPJ.2016.11.895  0.472
2017 Zhao R, Kennedy K, Li Q, Perozo E, Goldstein SA. Identification of Activating and Inhibiting Gating Modifier Toxins that Target the S3-S4 Loop of the Human Proton Channel, hHv1 Biophysical Journal. 112: 415a. DOI: 10.1016/J.BPJ.2016.11.2223  0.656
2017 Kennedy K, Zhao R, Li Q, Perozo E, De Blas GA, Pavarotti MA, Arias R, Mayorga LS, Goldstein SA. A Designer Peptide Toxin Isolated by Phage Display that Inhibits the Human Voltage-Gated Proton Channel, hHv1 Biophysical Journal. 112: 415a. DOI: 10.1016/J.BPJ.2016.11.2222  0.651
2017 Plant LD, Marks JD, Goldstein SA. Sumoylation of Na V 1.2 Channels Mediates the Early Response to Acute Hypoxia in Central Neurons Biophysical Journal. 112: 183a. DOI: 10.1016/j.bpj.2016.11.1014  0.387
2016 Plant LD, Marks JD, Goldstein SA. SUMOylation of Na1.2 channels mediates the early response to acute hypoxia in central neurons. Elife. 5. PMID 28029095 DOI: 10.7554/eLife.20054  0.784
2015 Zhao R, Dai H, Mendelman N, Cuello LG, Chill JH, Goldstein SA. Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. Proceedings of the National Academy of Sciences of the United States of America. PMID 26627718 DOI: 10.1073/Pnas.1514728112  0.832
2015 Crump SM, Hu Z, Kant R, Levy DI, Goldstein SA, Abbott GW. Kcne4 deletion sex and age specifically impairs cardiac repolarization in mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26399785 DOI: 10.1096/fj.15-278754  0.426
2014 Plant LD, Xiong D, Dai H, Goldstein SA. Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits. Proceedings of the National Academy of Sciences of the United States of America. 111: E1438-46. PMID 24591645 DOI: 10.1073/pnas.1323548111  0.821
2013 Silva JR, Goldstein SA. Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). The Journal of General Physiology. 141: 323-34. PMID 23401572 DOI: 10.1085/Jgp.201210910  0.589
2013 Silva JR, Goldstein SA. Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: wild-type skeletal muscle Na(V)1.4. The Journal of General Physiology. 141: 309-21. PMID 23401571 DOI: 10.1085/Jgp.201210909  0.615
2013 Ruscic KJ, Miceli F, Villalba-Galea CA, Dai H, Mishina Y, Bezanilla F, Goldstein SA. IKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunits. Proceedings of the National Academy of Sciences of the United States of America. 110: E559-66. PMID 23359697 DOI: 10.1073/Pnas.1222616110  0.795
2012 Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Science Signaling. 5: ra84. PMID 23169818 DOI: 10.1126/scisignal.2003431  0.792
2012 Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. K2P1 Assembles with K2P3 or K2P9 to Form SUMO-Regulated Task Background Channels in Cerebellar Granule Neurons Biophysical Journal. 102: 412a. DOI: 10.1016/J.BPJ.2011.11.2252  0.396
2012 Ruscic K, Miceli F, Villalba-Galea C, Bezanilla F, Goldstein SA. KCNE1 Slows the Voltage Sensors of KCNQ1 Biophysical Journal. 102: 14a. DOI: 10.1016/J.Bpj.2011.11.100  0.389
2011 Goldstein SA. K2P potassium channels, mysterious and paradoxically exciting. Science Signaling. 4: pe35. PMID 21868351 DOI: 10.1126/scisignal.2002225  0.537
2011 Plant LD, Dowdell EJ, Dementieva IS, Marks JD, Goldstein SA. SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons. The Journal of General Physiology. 137: 441-54. PMID 21518833 DOI: 10.1085/jgp.201110604  0.855
2011 Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. Half of IKso in Rat Cerebellar Granule Neurons is Held in Reserve by Sumo Suppression of Plasma Membrane Channels Containing K2P1 Biophysical Journal. 100: 100a. DOI: 10.1016/J.BPJ.2010.12.753  0.364
2011 Ruscic KJ, Miceli F, Bezanilla F, Goldstein SA. Gating Current of the KCNQ1 Voltage-Gated Potassium Channel Biophysical Journal. 100: 426a. DOI: 10.1016/J.Bpj.2010.12.2518  0.483
2010 Levy DI, Cepaitis E, Wanderling S, Toth PT, Archer SL, Goldstein SA. The membrane protein MiRP3 regulates Kv4.2 channels in a KChIP-dependent manner. The Journal of Physiology. 588: 2657-68. PMID 20498229 DOI: 10.1113/Jphysiol.2010.191395  0.502
2010 Plant LD, Dementieva IS, Kollewe A, Olikara S, Marks JD, Goldstein SA. One SUMO is sufficient to silence the dimeric potassium channel K2P1. Proceedings of the National Academy of Sciences of the United States of America. 107: 10743-8. PMID 20498050 DOI: 10.1073/pnas.1004712107  0.831
2010 Silva JR, Goldstein SA. Recovery of Voltage-Gated Nav1.4 Channels from Slow Inactivation Reflects Memory of Prior Stimulation in Multiple Molecular Processes Biophysical Journal. 98: 111a. DOI: 10.1016/J.Bpj.2009.12.4197  0.718
2010 Plant LD, Zúñiga L, Olikara S, Marks JD, Goldstein SA. K2P1 Assembles with K2P3 or K2P9 to Form Sumo-Regulated Task Background Channels Biophysical Journal. 98: 710a. DOI: 10.1016/J.BPJ.2009.12.3894  0.433
2010 Plant LD, Zúñiga L, Olikara S, Goldstein SA. One Sumo is Sufficient to Silence the Dimeric Background Potassium Channel K2P1 Biophysical Journal. 98: 536a. DOI: 10.1016/J.BPJ.2009.12.2907  0.579
2009 Takacs Z, Toups M, Kollewe A, Johnson E, Cuello LG, Driessens G, Biancalana M, Koide A, Ponte CG, Perozo E, Gajewski TF, Suarez-Kurtz G, Koide S, Goldstein SA. A designer ligand specific for Kv1.3 channels from a scorpion neurotoxin-based library. Proceedings of the National Academy of Sciences of the United States of America. 106: 22211-6. PMID 20007782 DOI: 10.1073/Pnas.0910123106  0.824
2009 Kollewe A, Lau AY, Sullivan A, Roux B, Goldstein SA. A structural model for K2P potassium channels based on 23 pairs of interacting sites and continuum electrostatics. The Journal of General Physiology. 134: 53-68. PMID 19564427 DOI: 10.1085/Jgp.200910235  0.829
2009 Dementieva IS, Tereshko V, McCrossan ZA, Solomaha E, Araki D, Xu C, Grigorieff N, Goldstein SA. Pentameric assembly of potassium channel tetramerization domain-containing protein 5. Journal of Molecular Biology. 387: 175-91. PMID 19361449 DOI: 10.1016/J.Jmb.2009.01.030  0.825
2008 Thomas D, Plant LD, Wilkens CM, McCrossan ZA, Goldstein SA. Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron. 58: 859-70. PMID 18579077 DOI: 10.1016/j.neuron.2008.04.016  0.765
2008 Levy DI, Wanderling S, Biemesderfer D, Goldstein SA. MiRP3 acts as an accessory subunit with the BK potassium channel. American Journal of Physiology. Renal Physiology. 295: F380-7. PMID 18463315 DOI: 10.1152/ajprenal.00598.2007  0.628
2008 Soh H, Goldstein SA. I SA channel complexes include four subunits each of DPP6 and Kv4.2. The Journal of Biological Chemistry. 283: 15072-7. PMID 18364354 DOI: 10.1074/Jbc.M706964200  0.562
2008 O'Kelly I, Goldstein SA. Forward Transport of K2p3.1: mediation by 14-3-3 and COPI, modulation by p11. Traffic (Copenhagen, Denmark). 9: 72-8. PMID 17908283 DOI: 10.1111/j.1600-0854.2007.00663.x  0.764
2007 Chen H, Goldstein SA. Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus. Biophysical Journal. 93: 2332-40. PMID 17545244 DOI: 10.1529/biophysj.107.109702  0.454
2006 Plant LD, Bowers PN, Liu Q, Morgan T, Zhang T, State MW, Chen W, Kittles RA, Goldstein SA. A common cardiac sodium channel variant associated with sudden infant death in African Americans, SCN5A S1103Y. The Journal of Clinical Investigation. 116: 430-5. PMID 16453024 DOI: 10.1172/Jci25618  0.816
2006 Abbott GW, Butler MH, Goldstein SA. Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 293-301. PMID 16449802 DOI: 10.1096/fj.05-5070com  0.793
2005 Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacological Reviews. 57: 527-40. PMID 16382106 DOI: 10.1124/Pr.57.4.12  0.847
2005 Plant LD, Rajan S, Goldstein SA. K2P channels and their protein partners. Current Opinion in Neurobiology. 15: 326-33. PMID 15922586 DOI: 10.1016/j.conb.2005.05.008  0.858
2005 Rajan S, Plant LD, Rabin ML, Butler MH, Goldstein SA. Sumoylation silences the plasma membrane leak K+ channel K2P1. Cell. 121: 37-47. PMID 15820677 DOI: 10.1016/j.cell.2005.01.019  0.82
2004 Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N. Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. Neuron. 41: 513-9. PMID 14980201 DOI: 10.1016/S0896-6273(04)00050-9  0.835
2004 Levy DI, Velazquez H, Goldstein SA, Bockenhauer D. Segment-specific expression of 2P domain potassium channel genes in human nephron. Kidney International. 65: 918-26. PMID 14871411 DOI: 10.1111/j.1523-1755.2004.00458.x  0.791
2004 Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA. Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. The Journal of Biological Chemistry. 279: 5549-54. PMID 14623880 DOI: 10.1074/Jbc.M311332200  0.839
2003 Chen H, Kim LA, Rajan S, Xu S, Goldstein SA. Charybdotoxin binding in the I(Ks) pore demonstrates two MinK subunits in each channel complex. Neuron. 40: 15-23. PMID 14527430 DOI: 10.1016/S0896-6273(03)00570-1  0.872
2003 Chen H, Sesti F, Goldstein SA. Pore- and state-dependent cadmium block of I(Ks) channels formed with MinK-55C and wild-type KCNQ1 subunits. Biophysical Journal. 84: 3679-89. PMID 12770875 DOI: 10.1016/S0006-3495(03)75097-8  0.66
2003 Sesti F, Rajan S, Gonzalez-Colaso R, Nikolaeva N, Goldstein SA. Hyperpolarization moves S4 sensors inward to open MVP, a methanococcal voltage-gated potassium channel. Nature Neuroscience. 6: 353-61. PMID 12640457 DOI: 10.1038/Nn1028  0.851
2002 O'Kelly I, Butler MH, Zilberberg N, Goldstein SA. Forward transport. 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. Cell. 111: 577-88. PMID 12437930 DOI: 10.1016/S0092-8674(02)01040-1  0.758
2002 Abbott GW, Goldstein SA. Disease-associated mutations in KCNE potassium channel subunits (MiRPs) reveal promiscuous disruption of multiple currents and conservation of mechanism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 390-400. PMID 11874988 DOI: 10.1096/fj.01-0520hyp  0.375
2002 Zilberberg N, Ilan N, Goldstein SA. KCNKØ: opening and closing the 2-P-domain potassium leak channel entails "C-type" gating of the outer pore. Neuron. 32: 635-48. PMID 11719204 DOI: 10.1016/S0896-6273(01)00503-7  0.555
2001 Sesti F, Shih TM, Nikolaeva N, Goldstein SA. Immunity to K1 killer toxin: internal TOK1 blockade. Cell. 105: 637-44. PMID 11389833 DOI: 10.1016/S0092-8674(01)00376-2  0.69
2001 Abbott GW, Goldstein SA, Sesti F. Do all voltage-gated potassium channels use MiRPs? Circulation Research. 88: 981-3. PMID 11375265 DOI: 10.1161/Hh1001.091869  0.687
2001 Lopes CM, Zilberberg N, Goldstein SA. Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers. The Journal of Biological Chemistry. 276: 24449-52. PMID 11358956 DOI: 10.1074/jbc.C100184200  0.402
2001 Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N. Potassium leak channels and the KCNK family of two-P-domain subunits. Nature Reviews. Neuroscience. 2: 175-84. PMID 11256078 DOI: 10.1038/35058574  0.575
2001 Abbott GW, Butler MH, Bendahhou S, Dalakas MC, Ptacek LJ, Goldstein SA. MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. Cell. 104: 217-31. PMID 11207363 DOI: 10.1016/S0092-8674(01)00207-0  0.538
2001 Ilan N, Goldstein SA. Kcnkø: single, cloned potassium leak channels are multi-ion pores. Biophysical Journal. 80: 241-53. PMID 11159398 DOI: 10.1016/S0006-3495(01)76010-9  0.558
2001 Zilberberg N, Ilan N, Gonzalez-Colaso R, Goldstein SA. Opening and closing of KCNKO potassium leak channels is tightly regulated. The Journal of General Physiology. 116: 721-34. PMID 11055999 DOI: 10.1085/JGP.116.5.721  0.576
2000 Sesti F, Abbott GW, Wei J, Murray KT, Saksena S, Schwartz PJ, Priori SG, Roden DM, George AL, Goldstein SA. A common polymorphism associated with antibiotic-induced cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 97: 10613-8. PMID 10984545 DOI: 10.1073/Pnas.180223197  0.609
2000 Sesti F, Tai KK, Goldstein SA. MinK endows the I(Ks) potassium channel pore with sensitivity to internal tetraethylammonium. Biophysical Journal. 79: 1369-78. PMID 10968999 DOI: 10.1016/S0006-3495(00)76389-2  0.816
2000 Lopes CM, Gallagher PG, Buck ME, Butler MH, Goldstein SA. Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. The Journal of Biological Chemistry. 275: 16969-78. PMID 10748056 DOI: 10.1074/jbc.M001948200  0.56
2000 Abbott GW, Goldstein SA. A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). Quarterly Reviews of Biophysics. 31: 357-98. PMID 10709243 DOI: 10.1017/S0033583599003467  0.463
1999 Ahmed A, Sesti F, Ilan N, Shih TM, Sturley SL, Goldstein SA. A molecular target for viral killer toxin: TOK1 potassium channels. Cell. 99: 283-91. PMID 10555144 DOI: 10.1016/S0092-8674(00)81659-1  0.753
1999 Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 97: 175-87. PMID 10219239 DOI: 10.1016/S0092-8674(00)80728-X  0.726
1998 Sesti F, Goldstein SA. Single-channel characteristics of wild-type IKs channels and channels formed with two minK mutants that cause long QT syndrome. The Journal of General Physiology. 112: 651-63. PMID 9834138 DOI: 10.1085/Jgp.112.6.651  0.769
1998 Tai KK, Goldstein SA. The conduction pore of a cardiac potassium channel. Nature. 391: 605-8. PMID 9468141 DOI: 10.1038/35416  0.71
1997 Tai KK, Wang KW, Goldstein SA. MinK potassium channels are heteromultimeric complexes. The Journal of Biological Chemistry. 272: 1654-8. PMID 8999841 DOI: 10.1074/jbc.272.3.1654  0.691
1996 Wang KW, Tai KK, Goldstein SA. MinK residues line a potassium channel pore. Neuron. 16: 571-7. PMID 8785054 DOI: 10.1016/S0896-6273(00)80076-8  0.699
1996 Goldstein SA, Colatsky TJ. Ion channels: too complex for rational drug design? Neuron. 16: 913-9. PMID 8630249 DOI: 10.1016/S0896-6273(00)80114-2  0.372
1995 Ketchum KA, Joiner WJ, Sellers AJ, Kaczmarek LK, Goldstein SA. A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem. Nature. 376: 690-5. PMID 7651518 DOI: 10.1038/376690A0  0.615
1995 Wang KW, Goldstein SA. Subunit composition of minK potassium channels. Neuron. 14: 1303-9. PMID 7605639 DOI: 10.1016/0896-6273(95)90277-5  0.568
1994 Goldstein SA, Pheasant DJ, Miller C. The charybdotoxin receptor of a Shaker K+ channel: peptide and channel residues mediating molecular recognition. Neuron. 12: 1377-88. PMID 7516689 DOI: 10.1016/0896-6273(94)90452-9  0.608
1994 Goldstein SA, Miller C. Mechanism of charybdotoxin block of a voltage-gated K+ channel. Biophysical Journal. 65: 1613-9. PMID 7506068 DOI: 10.1016/S0006-3495(93)81200-1  0.554
1992 Goldstein SA, Miller C. A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity. Biophysical Journal. 62: 5-7. PMID 1376173 DOI: 10.1016/S0006-3495(92)81760-5  0.618
1991 Hausdorff SF, Goldstein SA, Rushin EE, Miller C. Functional characterization of a minimal K+ channel expressed from a synthetic gene. Biochemistry. 30: 3341-6. PMID 2009272 DOI: 10.1021/Bi00227A025  0.629
1991 Goldstein SA, Miller C. Site-specific mutations in a minimal voltage-dependent K+ channel alter ion selectivity and open-channel block. Neuron. 7: 403-8. PMID 1910787 DOI: 10.1016/0896-6273(91)90292-8  0.658
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