cached image

Arnold Levine, PhD - Publications

Affiliations: 
Systems Biology Institute for Advanced Study, Princeton, NJ, United States 
Area:
p53 tumor suppressor gene
Website:
http://www.sns.ias.edu/~alevine/

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Boeke JD, Burns KH, Chiappinelli KB, Classon M, Coffin JM, DeCarvalho DD, Dukes JD, Greenbaum B, Kassiotis G, Knutson SK, Levine AJ, Nath A, Papa S, Rios D, Sedivy J, et al. Proceedings of the inaugural Dark Genome Symposium: November 2022. Mobile Dna. 14: 18. PMID 37990347 DOI: 10.1186/s13100-023-00306-5  0.524
2022 Hoyos D, Zappasodi R, Schulze I, Sethna Z, de Andrade KC, Bajorin DF, Bandlamudi C, Callahan MK, Funt SA, Hadrup SR, Holm JS, Rosenberg JE, Shah SP, Vázquez-García I, Weigelt B, ... ... Levine AJ, et al. Author Correction: Fundamental immune-oncogenicity trade-offs define driver mutation fitness. Nature. PMID 35641605 DOI: 10.1038/s41586-022-04879-8  0.529
2022 Hoyos D, Zappasodi R, Schulze I, Sethna Z, de Andrade KC, Bajorin DF, Bandlamundi C, Callahan MK, Funt SA, Hadrup SR, Holm JS, Rosenberg JE, Shah SP, Vázquez-García I, Weigelt B, ... ... Levine AJ, et al. Fundamental immune-oncogenicity trade-offs define driver mutation fitness. Nature. PMID 35545680 DOI: 10.1038/s41586-022-04696-z  0.572
2022 Hoyos D, Greenbaum B, Levine AJ. The genotypes and phenotypes of missense mutations in the proline domain of the p53 protein. Cell Death and Differentiation. 29: 938-945. PMID 35383292 DOI: 10.1038/s41418-022-00980-7  0.573
2019 Nogalski MT, Solovyov A, Kulkarni AS, Desai N, Oberstein A, Levine AJ, Ting DT, Shenk T, Greenbaum BD. A tumor-specific endogenous repetitive element is induced by herpesviruses. Nature Communications. 10: 90. PMID 30626867 DOI: 10.1038/S41467-018-07944-X  0.606
2017 Balachandran VP, Łuksza M, Zhao JN, Makarov V, Moral JA, Remark R, Herbst B, Askan G, Bhanot U, Senbabaoglu Y, Wells DK, Cary CIO, Grbovic-Huezo O, Attiyeh M, Medina B, ... ... Levine AJ, et al. Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer. Nature. PMID 29132146 DOI: 10.1038/Nature24462  0.542
2017 Łuksza M, Riaz N, Makarov V, Balachandran VP, Hellmann MD, Solovyov A, Rizvi NA, Merghoub T, Levine AJ, Chan TA, Wolchok JD, Greenbaum BD. A neoantigen fitness model predicts tumour response to checkpoint blockade immunotherapy. Nature. PMID 29132144 DOI: 10.1038/Nature24473  0.561
2016 Zhu J, Dou Z, Sammons MA, Levine AJ, Berger SL. Lysine methylation represses p53 activity in teratocarcinoma cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27535933 DOI: 10.1073/Pnas.1610387113  0.305
2016 Levine AJ, Ting DT, Greenbaum BD. P53 and the defenses against genome instability caused by transposons and repetitive elements. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 27172878 DOI: 10.1002/Bies.201600031  0.623
2016 Tanne A, Muniz L, Ting D, Levine A, Bhardwaj N, Greenbaum B. Abstract A077: Unraveling predicted immunomodulatory effects of novel cancer-associated noncoding RNAs Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A077  0.643
2016 Solovyov A, Tanne A, Muniz L, Cocco S, Monasson R, Levine A, Ting DT, Bhardwaj N, Greenbaum B. Abstract A087: Quantifying the landscape of immunostimulatory tumoral RNA Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A087  0.622
2016 Solovyov A, Tanne A, Ting D, Levine A, Bhardwaj N, Greenbaum B. Abstract 531: The landscape of immunostimulatory RNA transcription Cancer Research. 76: 531-531. DOI: 10.1158/1538-7445.Am2016-531  0.636
2016 Wong C, Vosburgh E, Levine A, Proia D, Xu E. Abstract 267: Preclinical investigation of the HSP90 inhibitor, ganetespib, in combination with FDA-approved cytotoxic agents for their potential anti-tumor effects on human neuroendocrine tumors Cancer Research. 76: 267-267. DOI: 10.1158/1538-7445.Am2016-267  0.327
2015 Tanne A, Muniz LR, Puzio-Kuter A, Leonova KI, Gudkov AV, Ting DT, Monasson R, Cocco S, Levine AJ, Bhardwaj N, Greenbaum BD. Distinguishing the immunostimulatory properties of noncoding RNAs expressed in cancer cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26575629 DOI: 10.1073/Pnas.1517584112  0.608
2015 Levine AJ, Phipps AI, Baron JA, Buchanan DD, Ahnen DJ, Cohen S, Lindor NM, Newcomb PA, Rosty C, Haile RW, Laird PW, Weisenberger DJ. Clinicopathological risk factor distributions for MLH1 promoter region methylation in CIMP positive tumors. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. PMID 26512054 DOI: 10.1158/1055-9965.Epi-15-0935  0.492
2015 Weisenberger DJ, Levine AJ, Long TI, Buchanan DD, Walters R, Clendenning M, Rosty C, Joshi AD, Stern MC, Le Marchand L, Lindor NM, Daftary D, Gallinger S, Selander T, Bapat B, et al. Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 512-9. PMID 25587051 DOI: 10.1158/1055-9965.Epi-14-1161  0.472
2015 Tanne AJ, Muniz LR, Ting DT, Solovyov AV, Levine A, Greenbaum B, Bhardwaj N. Unraveling predicted immunomodulatory effects of novel cancer-associated non-coding RNAs Journal For Immunotherapy of Cancer. 3: P396. DOI: 10.1186/2051-1426-3-S2-P396  0.639
2014 Yi L, Sun Y, Levine A. Selected drugs that inhibit DNA methylation can preferentially kill p53 deficient cells. Oncotarget. 5: 8924-36. PMID 25238040 DOI: 10.18632/Oncotarget.2441  0.405
2014 Greenbaum BD, Cocco S, Levine AJ, Monasson R. Quantitative theory of entropic forces acting on constrained nucleotide sequences applied to viruses. Proceedings of the National Academy of Sciences of the United States of America. 111: 5054-9. PMID 24639520 DOI: 10.1073/Pnas.1402285111  0.539
2013 Zhang C, Lin M, Zhao Y, Zheng T, Wang J, Levine A, Feng Z, Hu W. Abstract 784: Chronic stress promotes tumorigenesis through attenuation of p53 function . Cancer Research. 73: 784-784. DOI: 10.1158/1538-7445.Am2013-784  0.346
2012 Levine AJ, Greenbaum B. The maintenance of epigenetic states by p53: the guardian of the epigenome. Oncotarget. 3: 1503-4. PMID 23237909 DOI: 10.18632/Oncotarget.780  0.588
2012 Cortessis VK, Thomas DC, Levine AJ, Breton CV, Mack TM, Siegmund KD, Haile RW, Laird PW. Environmental epigenetics: prospects for studying epigenetic mediation of exposure-response relationships. Human Genetics. 131: 1565-89. PMID 22740325 DOI: 10.1007/S00439-012-1189-8  0.436
2012 Greenbaum BD, Li OT, Poon LL, Levine AJ, Rabadan R. Viral reassortment as an information exchange between viral segments. Proceedings of the National Academy of Sciences of the United States of America. 109: 3341-6. PMID 22331898 DOI: 10.1073/Pnas.1113300109  0.525
2012 Levine AJ, Win AK, Buchanan DD, Jenkins MA, Baron JA, Young JP, Long TI, Weisenberger DJ, Laird PW, McCall RL, Duggan DJ, Haile RW. Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry. Cancer Prevention Research (Philadelphia, Pa.). 5: 328-35. PMID 22144422 DOI: 10.1158/1940-6207.Capr-11-0419  0.454
2011 Blandino G, Deppert W, Hainaut P, Levine A, Lozano G, Olivier M, Rotter V, Wiman K, Oren M. Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop. Cell Death and Differentiation. 19: 180-3. PMID 22095277 DOI: 10.1038/Cdd.2011.148  0.334
2011 Jimenez-Baranda S, Greenbaum B, Manches O, Handler J, Rabadán R, Levine A, Bhardwaj N. Oligonucleotide motifs that disappear during the evolution of influenza virus in humans increase alpha interferon secretion by plasmacytoid dendritic cells. Journal of Virology. 85: 3893-904. PMID 21307198 DOI: 10.1128/Jvi.01908-10  0.608
2010 Lane D, Levine A. p53 Research: the past thirty years and the next thirty years. Cold Spring Harbor Perspectives in Biology. 2: a000893. PMID 20463001 DOI: 10.1101/Cshperspect.A000893  0.382
2010 Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proceedings of the National Academy of Sciences of the United States of America. 107: 7455-60. PMID 20378837 DOI: 10.1073/Pnas.1001006107  0.347
2009 Greenbaum BD, Rabadan R, Levine AJ. Patterns of oligonucleotide sequences in viral and host cell RNA identify mediators of the host innate immune system. Plos One. 4: e5969. PMID 19536338 DOI: 10.1371/Journal.Pone.0005969  0.565
2009 Shi H, Tan SJ, Zhong H, Hu W, Levine A, Xiao CJ, Peng Y, Qi XB, Shou WH, Ma RL, Li Y, Su B, Lu X. Winter temperature and UV are tightly linked to genetic changes in the p53 tumor suppressor pathway in Eastern Asia. American Journal of Human Genetics. 84: 534-41. PMID 19344876 DOI: 10.1016/J.Ajhg.2009.03.009  0.316
2008 Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N, Young J, Jenkins MA, Hopper JL, Baron JA, Buchanan D, Casey G, Levine AJ, Le Marchand L, Gallinger S, et al. Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 17: 3208-15. PMID 18990764 DOI: 10.1158/1055-9965.Epi-08-0512  0.454
2008 Greenbaum BD, Levine AJ, Bhanot G, Rabadan R. Patterns of evolution and host gene mimicry in influenza and other RNA viruses. Plos Pathogens. 4: e1000079. PMID 18535658 DOI: 10.1371/Journal.Ppat.1000079  0.577
2008 Yeang CH, McCormick F, Levine A. Combinatorial patterns of somatic gene mutations in cancer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2605-22. PMID 18434431 DOI: 10.1096/Fj.08-108985  0.332
2008 Riley T, Sontag E, Chen P, Levine A. Transcriptional control of human p53-regulated genes. Nature Reviews. Molecular Cell Biology. 9: 402-12. PMID 18431400 DOI: 10.1038/Nrm2395  0.399
2007 Hu W, Feng Z, Teresky A, Levine A. Identifying novel p53-target genes and their functional analysis Nature Protocols. DOI: 10.1038/Nprot.2007.507  0.305
2006 Siegmund KD, Levine AJ, Chang J, Laird PW. Modeling exposures for DNA methylation profiles. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 15: 567-72. PMID 16537717 DOI: 10.1158/1055-9965.Epi-05-0717  0.429
2005 Bond GL, Hu W, Levine A. A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect. Cancer Research. 65: 5481-4. PMID 15994915 DOI: 10.1158/0008-5472.Can-05-0825  0.324
2004 Chen W, Cooper TK, Zahnow CA, Overholtzer M, Zhao Z, Ladanyi M, Karp JE, Gokgoz N, Wunder JS, Andrulis IL, Levine AJ, Mankowski JL, Baylin SB. Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell. 6: 387-98. PMID 15488761 DOI: 10.1016/J.Ccr.2004.08.030  0.616
2003 Overholtzer M, Rao PH, Favis R, Lu XY, Elowitz MB, Barany F, Ladanyi M, Gorlick R, Levine AJ. The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 100: 11547-52. PMID 12972634 DOI: 10.1073/Pnas.1934852100  0.636
2003 Jin S, Kalkum M, Overholtzer M, Stoffel A, Chait BT, Levine AJ. CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals. Genes & Development. 17: 359-67. PMID 12569127 DOI: 10.1101/Gad.1047003  0.594
2003 Soon LL, Yie TA, Shvarts A, Levine AJ, Su F, Tchou-Wong KM. Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation. The Journal of Biological Chemistry. 278: 11465-70. PMID 12529380 DOI: 10.1074/jbc.M210945200  0.439
2002 Su F, Overholtzer M, Besser D, Levine AJ. WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. Genes & Development. 16: 46-57. PMID 11782444 DOI: 10.1101/Gad.942902  0.678
2001 Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ. Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes & Development. 15: 1796-807. PMID 11459829 DOI: 10.1101/Gad.894301  0.507
2000 Jin S, Martinek S, Joo WS, Wortman JR, Mirkovic N, Sali A, Yandell MD, Pavletich NP, Young MW, Levine AJ. Identification and characterization of a p53 homologue in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 97: 7301-6. PMID 10860994 DOI: 10.1073/Pnas.97.13.7301  0.313
2000 Xu L, Corcoran RB, Welsh JW, Pennica D, Levine AJ. WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene. Genes & Development. 14: 585-95. PMID 10716946  0.482
1999 Ahn J, Murphy M, Kratowicz S, Wang A, Levine AJ, George DL. Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction. Oncogene. 18: 5954-8. PMID 10557083 DOI: 10.1038/sj.onc.1202986  0.301
1998 Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, Watanabe C, Cohen RL, Melhem MF, Finley GG, Quirke P, ... ... Levine AJ, et al. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proceedings of the National Academy of Sciences of the United States of America. 95: 14717-22. PMID 9843955 DOI: 10.1073/Pnas.95.25.14717  0.671
1998 Zhang CC, Yang JM, White E, Murphy M, Levine A, Hait WN. The role of MAP4 expression in the sensitivity to paclitaxel and resistance to vinca alkaloids in p53 mutant cells. Oncogene. 16: 1617-24. PMID 9569030 DOI: 10.1038/Sj.Onc.1201658  0.31
1997 Marechal V, Elenbaas B, Taneyhill L, Piette J, Mechali M, Nicolas J, Levine AJ, Moreau J. Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis. Oncogene. 14: 1427-1433. PMID 9136986 DOI: 10.1038/Sj.Onc.1200967  0.671
1996 Lutzker SG, Levine AJ. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Nature Medicine. 2: 804-10. PMID 8673928 DOI: 10.1038/nm0796-804  0.33
1995 Riou G, Barrois M, Prost S, Terrier MJ, Theodore C, Levine AJ. The p53 and mdm-2 genes in human testicular germ-cell tumors. Molecular Carcinogenesis. 12: 124-31. PMID 7893365 DOI: 10.1002/mc.2940120303  0.305
1995 Lee S, Elenbaas B, Levine A, Griffith J. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches Cell. 81: 1013-1020. PMID 7600570 DOI: 10.1016/S0092-8674(05)80006-6  0.333
1994 Wu X, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 91: 3602-6. PMID 8170954 DOI: 10.1073/pnas.91.9.3602  0.304
1994 Levine AJ, Perry ME, Chang A, Silver A, Dittmer D, Wu M, Welsh D. The 1993 Walter Hubert Lecture: the role of the p53 tumour-suppressor gene in tumorigenesis. British Journal of Cancer. 69: 409-16. PMID 8123467 DOI: 10.1038/bjc.1994.76  0.308
1992 Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell. 69: 1237-1245. PMID 1535557 DOI: 10.1016/0092-8674(92)90644-R  0.686
1992 Seto E, Usheva A, Zambetti GP, Momand J, Horikoshi N, Weinmann R, Levine AJ, Shenk T. Wild-type p53 binds to the TATA-binding protein and represses transcription Proceedings of the National Academy of Sciences of the United States of America. 89: 12028-12032. PMID 1465435 DOI: 10.1073/Pnas.89.24.12028  0.674
1991 Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature. 351: 453-6. PMID 2046748 DOI: 10.1038/351453A0  0.702
1991 Zambetti GP, Quartin RS, Martinez J, Georgoff I, Momand J, Dittmer D, Finlay CA, Levine AJ. Regulation of transformation and the cell cycle by p53 Cold Spring Harbor Symposia On Quantitative Biology. 56: 219-225. PMID 1819488 DOI: 10.1101/Sqb.1991.056.01.027  0.659
1990 Levine AJ, Momand J. Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products. Biochimica Et Biophysica Acta. 1032: 119-36. PMID 2142001 DOI: 10.1016/0304-419X(90)90015-S  0.659
1990 Levine AJ. Tumor suppressor genes Bioessays. 12: 60-66. PMID 2140509 DOI: 10.1002/bies.950120203  0.326
1975 Van Der Vliet PC, Levine AJ, Ensinger MJ, Ginsberg HS. Thermolabile DNA binding proteins from cells infected with a temperature-sensitive mutant of adenovrius defective in viral DNA synthesis. Journal of Virology. 15: 348-54. PMID 803568 DOI: 10.1128/jvi.15.2.348-354.1975  0.51
1975 Sen A, Laipis PJ, Levine AJ. DNA replication in SV40-infected cells. XI. The properties of SV40 DNA and nucleoprotein complex synthesized in the presence of cycloheximide. Intervirology. 5: 122-36. PMID 172469 DOI: 10.1159/000149890  0.593
1975 Laipis PJ, Sen A, Levine AJ, Mulder C. DNA replication in SV40 infected cells X. The structure of the 16 S gap circle intermediate in SV40 DNA synthesis. Virology. 68: 115-23. PMID 171842 DOI: 10.1016/0042-6822(75)90153-1  0.591
1973 Laipis PJ, Levine AJ. DNA replication in SV40-infected cells. IX. The inhibition of a gap-filling step during discontinuous synthesis of SV40 DNA. Virology. 56: 580-94. PMID 4357056 DOI: 10.1016/0042-6822(73)90059-7  0.598
1973 Jaenisch R, Levine AJ. DNA replication of SV40-infected cells. VII. Formation of SV40 catenated and circular dimers. Journal of Molecular Biology. 73: 199-212. PMID 4347738  0.428
1972 Jaenisch R, Levine AJ. DNA replication in SV40-infected cells. VI. The effect of cycloheximide on the formation of SV40 oligomeric DNA. Virology. 48: 373-9. PMID 4337027  0.423
1972 Dubbs DR, Kit S, Jaenisch R, Levine AJ. Isolation of simian virus 40 recombinants from cells infected with oligomeric forms of simian virus 40 deoxyribonucleic acid. Journal of Virology. 9: 717-9. PMID 4336567 DOI: 10.1128/Jvi.9.4.717-719.1972  0.419
1971 Jaenisch R, Levine AJ. Infection of primary African green monkey cells with SV40 monomeric and dimeric DNA. Journal of Molecular Biology. 61: 735-8. PMID 4332233  0.413
1971 Jaenisch R, Mayer A, Levine A. Replicating SV40 molecules containing closed circular template DNA strands. Nature. 233: 72-75. PMID 4330296 DOI: 10.1038/Newbio233072A0  0.301
1969 Levine AJ, Sinsheimer RL. The process of infection with bacteriophage phiX174. XXVII. Synthesis of a viral-specific chloramphenicol-resistant protein in phiX174-infected cells. Journal of Molecular Biology. 39: 655-68. PMID 5357216 DOI: 10.1016/0022-2836(69)90151-X  0.495
1969 Levine AJ, Sinsheimer RL. Isolation of a chloramphenicol-resistant protein from lambda-infected cells. Proceedings of the National Academy of Sciences of the United States of America. 62: 1226-8. PMID 5256419 DOI: 10.1073/Pnas.62.4.1226  0.501
1969 Levine AJ, Sinsheimer RL. The process of infection with bacteriophage phiX174. XXV. Studies with bacteriophage phiX174 mutants blocked in progeny replicative form DNA synthesis. Journal of Molecular Biology. 39: 619-39. PMID 4901860 DOI: 10.1016/0022-2836(69)90149-1  0.494
1968 Levine AJ, Sinsheimer RL. The process of infection with bacteriophage phi-X174. XIX. Isolation and characterization of a chloramphenicol-resistant protein from phi-X-infected cells. Journal of Molecular Biology. 32: 567-78. PMID 4868758 DOI: 10.1016/0022-2836(68)90343-4  0.483
1968 Levine AJ, Ginsberg HS. Role of adenovirus structural proteins in the cessation of host-cell biosynthetic functions. Journal of Virology. 2: 430-9. PMID 4301313  0.52
1967 Levine AJ, Ginsberg HS. Mechanism by which fiber antigen inhibits multiplication of type 5 adenovirus. Journal of Virology. 1: 747-57. PMID 5630225  0.487
Show low-probability matches.