George F. Koob - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Neurobiology of emotion
Website:
https://www.scripps.edu/research/faculty/koob

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Year Citation  Score
2020 McConnell SA, Brandner AJ, Blank BA, Kearns DN, Koob GF, Vendruscolo LF, Tunstall BJ. Demand for fentanyl becomes inelastic following extended access to fentanyl vapor self-administration. Neuropharmacology. 182: 108355. PMID 33091459 DOI: 10.1016/j.neuropharm.2020.108355  0.92
2020 Tsai PJ, Keeley RJ, Carmack SA, Vendruscolo JCM, Lu H, Gu H, Vendruscolo LF, Koob GF, Lin CP, Stein EA, Yang Y. Converging Structural and Functional Evidence for a Rat Salience Network. Biological Psychiatry. PMID 32981657 DOI: 10.1016/j.biopsych.2020.06.023  0.92
2020 Ray LA, Grodin EN, Leggio L, Bechtholt AJ, Becker H, Feldstein Ewing SW, Jentsch JD, King AC, Mason BJ, O'Malley S, MacKillop J, Heilig M, Koob GF. The future of translational research on alcohol use disorder. Addiction Biology. e12903. PMID 32286721 DOI: 10.1111/adb.12903  1
2020 Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, ... ... Koob GF, et al. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Jci Insight. 5. PMID 32051339 DOI: 10.1172/jci.insight.131277  0.92
2019 Lee JS, Mukhopadhyay P, Matyas C, Trojnar E, Paloczi J, Yang YR, Blank BA, Savage C, Sorokin AV, Mehta NN, Vendruscolo JCM, Koob GF, Vendruscolo LF, Pacher P, Lohoff FW. PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease. Scientific Reports. 9: 17167. PMID 31748600 DOI: 10.1038/s41598-019-53603-6  0.92
2019 Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? Alcohol and Alcoholism (Oxford, Oxfordshire). 54: 497-502. PMID 31535696 DOI: 10.1093/alcalc/agz054  0.92
2019 Zorrilla EP, Koob GF. Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 188. PMID 31501652 DOI: 10.3389/fnbeh.2019.00188  1
2019 Zorrilla EP, Koob GF. Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 136. PMID 31293401 DOI: 10.3389/fnbeh.2019.00136  1
2019 Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. Plos Biology. 17: e2006421. PMID 30990816 DOI: 10.1371/journal.pbio.2006421  0.92
2019 Carmack SA, Keeley RJ, Vendruscolo JC, Lowery-Gionta EG, Lu H, Koob GF, Stein EA, Vendruscolo LF. Heroin addiction engages negative emotional learning brain circuits in rats. The Journal of Clinical Investigation. 130. PMID 30913040 DOI: 10.1172/JCI125534  0.92
2019 de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nature Communications. 10: 1238. PMID 30886240 DOI: 10.1038/s41467-019-09183-0  1
2019 Towers EB, Tunstall BJ, McCracken MM, Vendruscolo LF, Koob GF. Male and female mice develop escalation of heroin intake and dependence following extended access. Neuropharmacology. PMID 30880124 DOI: 10.1016/j.neuropharm.2019.03.019  0.92
2019 Tyler RE, Kim SW, Guo M, Joo Jang Y, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND. Detecting neuroinflammation in brain following chronic alcohol exposure in rats: a comparison between in vivo and in vitro TSPO radioligand binding. The European Journal of Neuroscience. PMID 30803059 DOI: 10.1111/ejn.14392  0.92
2019 Kwako LE, Schwandt ML, Ramchandani VA, Diazgranados N, Koob GF, Volkow ND, Blanco C, Goldman D. Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder. The American Journal of Psychiatry. appiajp201818030357. PMID 30606047 DOI: 10.1176/appi.ajp.2018.18030357  0.36
2018 Frantz K, Roberto M, Mason B, Koob GF, Volkow N, Rodriguez de Fonseca F. Larry Parsons: Researcher, mentor, and friend. Addiction Biology. 23: 1204-1206. PMID 30485629 DOI: 10.1111/adb.12686  0.64
2018 Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Journal of Neuroendocrinology. e12663. PMID 30456835 DOI: 10.1111/jne.12663  0.92
2018 Somkuwar SS, Quach LW, Quigley JA, Purohit DC, Fannon MJ, Koob GF, Mandyam CD. Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. Brain Sciences. 8. PMID 29949891 DOI: 10.3390/brainsci8070119  0.96
2018 Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Molecular Psychiatry. PMID 29880881 DOI: 10.1038/s41380-018-0080-y  1
2018 Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, ... ... Koob GF, et al. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [C]PBR28 studies in humans and rodents. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29777199 DOI: 10.1038/s41386-018-0085-x  0.92
2018 Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29703996 DOI: 10.1038/s41386-018-0054-4  0.92
2018 Kenny PJ, Hoyer D, Koob GF. Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou. Biological Psychiatry. PMID 29602521 DOI: 10.1016/j.biopsych.2018.02.009  1
2018 Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing aPromoter Polymorphism. Frontiers in Psychiatry. 9: 28. PMID 29497387 DOI: 10.3389/fpsyt.2018.00028  1
2018 Tian YH, Ma SX, Lee KW, Wee S, Koob GF, Lee SY, Jang CG. Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects. Scientific Reports. 8: 882. PMID 29343767 DOI: 10.1038/s41598-018-19207-2  0.84
2017 Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biological Psychiatry. PMID 29357981 DOI: 10.1016/j.biopsych.2017.10.031  1
2017 George O, Koob GF. Individual differences in the neuropsychopathology of addiction. Dialogues in Clinical Neuroscience. 19: 217-229. PMID 29302219  1
2017 Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 131: 96-103. PMID 29217282 DOI: 10.1016/j.neuropharm.2017.12.006  0.92
2017 Francesconi W, Szücs A, Berton F, Koob GF, Vendruscolo LF, Sanna PP. Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST). Psychopharmacology. PMID 28986608 DOI: 10.1007/s00213-017-4732-4  0.92
2017 Moore CF, Sabino V, Koob GF, Cottone P. Neuroscience of Compulsive Eating Behavior. Frontiers in Neuroscience. 11: 469. PMID 28883784 DOI: 10.3389/fnins.2017.00469  1
2017 Vendruscolo JC, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater S, Taffe M, Koob GF, Vendruscolo LF. Compulsive-Like Sufentanil Vapor Self-Administration in the Rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28812595 DOI: 10.1038/npp.2017.172  1
2017 Kwako LE, Koob GF. Neuroclinical Framework for the Role of Stress in Addiction. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 28653044  0.36
2017 Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF. Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking. Current Opinion in Behavioral Sciences. 13: 85-90. PMID 28603755 DOI: 10.1016/j.cobeha.2016.10.006  0.92
2017 de Guglielmo G, Kallupi M, Crawford E, Koob GF, Messing RO, George O. Optogenetic characterization of CeA CRF pathways in alcohol dependence Alcohol. 60: 235. DOI: 10.1016/j.alcohol.2017.02.319  1
2017 Messing RO, Pomrenze MB, de Guglielmo G, Kallupi M, Koob GF, George O. A distributed CRF network in rat extended amygdala regulates anxiety and excessive alcohol drinking Alcohol. 60: 212. DOI: 10.1016/j.alcohol.2017.02.221  1
2016 Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt J, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, ... ... Koob GF, et al. Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27986929 DOI: 10.1523/JNEUROSCI.2002-16.2016  1
2016 Moore CF, Sabino V, Koob GF, Cottone P. Pathological Overeating: Emerging Evidence for a Compulsivity Construct. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27922596 DOI: 10.1038/npp.2016.269  1
2016 Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27917870 DOI: 10.1038/npp.2016.270  1
2016 Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. Reply to: Neuroclinical Assessment of Addiction Needs to Incorporate Decision-Making Measures and Ecological Validity. Biological Psychiatry. PMID 27776735 DOI: 10.1016/j.biopsych.2016.08.029  0.36
2016 de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9446-53. PMID 27605618 DOI: 10.1523/JNEUROSCI.1395-16.2016  1
2016 Schmeichel BE, Herman MA, Roberto M, Koob GF. Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-Administration and Stress-Induced Reinstatement in Rats. Biological Psychiatry. PMID 27567312 DOI: 10.1016/j.biopsych.2016.06.010  0.64
2016 Priddy BM, Carmack SA, Thomas LC, Vendruscolo JC, Koob GF, Vendruscolo LF. Sex, strain, and estrous cycle influences on alcohol drinking in rats. Pharmacology, Biochemistry, and Behavior. PMID 27498303 DOI: 10.1016/j.pbb.2016.08.001  0.92
2016 Verheij MM, Vendruscolo LF, Caffino L, Giannotti G, Cazorla M, Fumagalli F, Riva MA, Homberg JR, Koob GF, Contet C. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8149-59. PMID 27488635 DOI: 10.1523/JNEUROSCI.2711-14.2016  1
2016 Koob GF. The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection. The Journal of Nervous and Mental Disease. PMID 27356121 DOI: 10.1097/NMD.0000000000000551  1
2016 Becker JB, Koob GF. Sex Differences in Animal Models: Focus on Addiction. Pharmacological Reviews. 68: 242-63. PMID 26772794 DOI: 10.1124/pr.115.011163  1
2016 Chavkin C, Koob GF. Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 373-4. PMID 26657953 DOI: 10.1038/npp.2015.258  1
2015 Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders. Biological Psychiatry. PMID 26772405 DOI: 10.1016/j.biopsych.2015.10.024  0.36
2015 Koob GF, Mason BJ. Existing and Future Drugs for the Treatment of the Dark Side of Addiction. Annual Review of Pharmacology and Toxicology. PMID 26514207 DOI: 10.1146/annurev-pharmtox-010715-103143  1
2015 You IJ, Wright SR, Garcia-Garcia AL, Tapper AR, Gardner PD, Koob GF, Leonardo ED, Bohn LM, Wee S. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26324408 DOI: 10.1038/npp.2015.268  1
2015 Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. The Journal of Clinical Investigation. PMID 26121746 DOI: 10.1172/JCI79828  1
2015 Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, et al. Brain pathways to recovery from alcohol dependence. Alcohol (Fayetteville, N.Y.). 49: 435-52. PMID 26074423 DOI: 10.1016/j.alcohol.2015.04.006  1
2015 Repunte-Canonigo V, Shin W, Vendruscolo LF, Lefebvre C, van der Stap L, Kawamura T, Schlosburg JE, Alvarez M, Koob GF, Califano A, Sanna PP. Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks. Genome Biology. 16: 68. PMID 25886852 DOI: 10.1186/s13059-015-0593-5  1
2015 Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6241-53. PMID 25878294 DOI: 10.1523/JNEUROSCI.3302-14.2015  1
2015 Litten RZ, Ryan ML, Falk DE, Reilly M, Fertig JB, Koob GF. Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment. Alcoholism, Clinical and Experimental Research. 39: 579-84. PMID 25833016 DOI: 10.1111/acer.12669  1
2015 Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4296-305. PMID 25762676 DOI: 10.1523/JNEUROSCI.1978-13.2015  1
2015 Koob GF, Griebel G. Pharmacology, biochemistry and behavior: the 2015 transition. Pharmacology, Biochemistry, and Behavior. 131: iii. PMID 25661528 DOI: 10.1016/j.pbb.2015.02.001  1
2015 Koob GF. The dark side of emotion: the addiction perspective. European Journal of Pharmacology. 753: 73-87. PMID 25583178 DOI: 10.1016/j.ejphar.2014.11.044  1
2015 Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1123-9. PMID 25367502 DOI: 10.1038/npp.2014.293  1
2015 Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF. Compulsive-like responding for opioid analgesics in rats with extended access. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 421-8. PMID 25060491 DOI: 10.1038/npp.2014.188  1
2015 Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology. 232: 453-63. PMID 25059540 DOI: 10.1007/s00213-014-3685-0  1
2015 Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addiction Biology. 20: 275-84. PMID 24330252 DOI: 10.1111/adb.12120  1
2015 Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology. 20: 56-68. PMID 23869743 DOI: 10.1111/adb.12077  1
2015 Saba LM, Flink SC, Vanderlinden LA, Israel Y, Tampier L, Colombo G, Kiianmaa K, Bell RL, Printz MP, Flodman P, Koob G, Richardson HN, Lombardo J, Hoffman PL, Tabakoff B. The sequenced rat brain transcriptome - its use in identifying networks predisposing alcohol consumption Febs Journal. DOI: 10.1111/febs.13358  1
2014 Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, ... ... Koob GF, et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17: 1751-8. PMID 25402857 DOI: 10.1038/nn.3872  1
2014 Koob GF. Neurocircuitry of alcohol addiction: synthesis from animal models. Handbook of Clinical Neurology. 125: 33-54. PMID 25307567 DOI: 10.1016/B978-0-444-62619-6.00003-3  1
2014 Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Molecular Neurodegeneration. 9: 26. PMID 24980976 DOI: 10.1186/1750-1326-9-26  1
2014 Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcoholism, Clinical and Experimental Research. 38: 2148-57. PMID 24961585 DOI: 10.1111/acer.12471  1
2014 George O, Koob GF, Vendruscolo LF. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology. 231: 3911-7. PMID 24923982 DOI: 10.1007/s00213-014-3623-1  1
2014 Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behavioural Brain Research. 271: 171-6. PMID 24914463 DOI: 10.1016/j.bbr.2014.06.003  1
2014 Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. Plos One. 9: e97216. PMID 24816773 DOI: 10.1371/journal.pone.0097216  1
2014 Mazei-Robison MS, Appasani R, Edwards S, Wee S, Taylor SR, Picciotto MR, Koob GF, Nestler EJ. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. Plos One. 9: e95962. PMID 24755634 DOI: 10.1371/journal.pone.0095962  1
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd ML, Crystal RG. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Human Gene Therapy. Clinical Development. 25: 40-9. PMID 24649839 DOI: 10.1089/humc.2013.231  1
2014 Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1722-31. PMID 24549104 DOI: 10.1038/npp.2014.20  1
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd M, Crystal RG. Fate of Systemically Administered Cocaine in Nonhuman Primates Treated with the dAd5GNE Anti-cocaine Vaccine. Human Gene Therapy. Clinical Development. PMID 24548017 DOI: 10.1089/hum.2013.231  0.92
2014 Zorrilla EP, Logrip ML, Koob GF. Corticotropin releasing factor: a key role in the neurobiology of addiction. Frontiers in Neuroendocrinology. 35: 234-44. PMID 24456850 DOI: 10.1016/j.yfrne.2014.01.001  1
2014 Buck CL, Vendruscolo LF, Koob GF, George O. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology. 231: 929-37. PMID 24221826 DOI: 10.1007/s00213-013-3307-2  1
2014 Gilpin NW, Roberto M, Koob GF, Schweitzer P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala. Neuropharmacology. 77: 294-302. PMID 24157490 DOI: 10.1016/j.neuropharm.2013.10.005  1
2014 Wise RA, Koob GF. The development and maintenance of drug addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 254-62. PMID 24121188 DOI: 10.1038/npp.2013.261  1
2014 Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. Addiction as a stress surfeit disorder. Neuropharmacology. 76: 370-82. PMID 23747571 DOI: 10.1016/j.neuropharm.2013.05.024  1
2014 Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addiction Biology. 19: 755-7. PMID 23639035 DOI: 10.1111/adb.12059  1
2014 Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. Hippocampal neurogenesis protects against cocaine-primed relapse. Addiction Biology. 19: 562-74. PMID 23278919 DOI: 10.1111/adb.12019  1
2013 Kreifeldt M, Le D, Treistman SN, Koob GF, Contet C. BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. Frontiers in Integrative Neuroscience. 7: 105. PMID 24416005 DOI: 10.3389/fnint.2013.00105  1
2013 Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19384-92. PMID 24305833 DOI: 10.1523/JNEUROSCI.1979-13.2013  1
2013 Zorrilla EP, Roberts AJ, Rivier JE, Koob GF. Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. Plos One. 8: e63942. PMID 24015170 DOI: 10.1371/journal.pone.0063942  1
2013 Cai X, Whitfield T, Moreno AY, Grant Y, Hixon MS, Koob GF, Janda KD. Probing the effects of hapten stability on cocaine vaccine immunogenicity. Molecular Pharmaceutics. 10: 4176-84. PMID 23927436 DOI: 10.1021/mp400214w  1
2013 Koob GF. Addiction is a Reward Deficit and Stress Surfeit Disorder. Frontiers in Psychiatry. 4: 72. PMID 23914176 DOI: 10.3389/fpsyt.2013.00072  1
2013 Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behavioural Pharmacology. 24: 356-62. PMID 23839030 DOI: 10.1097/FBP.0b013e3283644d15  1
2013 Kallupi M, Wee S, Edwards S, Whitfield TW, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biological Psychiatry. 74: 520-8. PMID 23751206 DOI: 10.1016/j.biopsych.2013.04.028  1
2013 Chen J, Repunte-Canonigo V, Kawamura T, Lefebvre C, Shin W, Howell LL, Hemby SE, Harvey BK, Califano A, Morales M, Koob GF, Sanna PP. Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor. Nature Communications. 4: 1955. PMID 23736082 DOI: 10.1038/ncomms2955  1
2013 Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2170-8. PMID 23660705 DOI: 10.1038/npp.2013.114  1
2013 Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9036-41. PMID 23650354 DOI: 10.1073/pnas.1219159110  1
2013 Koob GF. Negative reinforcement in drug addiction: the darkness within. Current Opinion in Neurobiology. 23: 559-63. PMID 23628232 DOI: 10.1016/j.conb.2013.03.011  1
2013 Cai X, Whitfield T, Hixon MS, Grant Y, Koob GF, Janda KD. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. Journal of Medicinal Chemistry. 56: 3701-9. PMID 23627877 DOI: 10.1021/jm400228w  1
2013 Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF. Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1867-75. PMID 23590881 DOI: 10.1017/S1461145713000308  1
2013 George O, Koob GF. Control of craving by the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 110: 4165-6. PMID 23483010 DOI: 10.1073/pnas.1301245110  1
2013 Robison AJ, Vialou V, Mazei-Robison M, Feng J, Kourrich S, Collins M, Wee S, Koob G, Turecki G, Neve R, Thomas M, Nestler EJ. Behavioral and structural responses to chronic cocaine require a feedforward loop involving ΔFosB and calcium/calmodulin-dependent protein kinase II in the nucleus accumbens shell. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4295-307. PMID 23467346 DOI: 10.1523/JNEUROSCI.5192-12.2013  1
2013 Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 976-84. PMID 23303056 DOI: 10.1038/npp.2012.261  1
2013 Zorrilla EP, Koob GF. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley. Neuroscience and Biobehavioral Reviews. 37: 1932-45. PMID 23220696 DOI: 10.1016/j.neubiorev.2012.11.019  1
2013 Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 67: 337-48. PMID 23220399 DOI: 10.1016/j.neuropharm.2012.11.026  1
2013 De BP, Pagovich OE, Hicks MJ, Rosenberg JB, Moreno AY, Janda KD, Koob GF, Worgall S, Kaminsky SM, Sondhi D, Crystal RG. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human Gene Therapy. 24: 58-66. PMID 23140508 DOI: 10.1089/hum.2012.163  1
2013 Jang CG, Whitfield T, Schulteis G, Koob GF, Wee S. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology. 225: 753-63. PMID 23007601 DOI: 10.1007/s00213-012-2864-0  1
2013 Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Current Topics in Behavioral Neurosciences. 13: 3-30. PMID 21744309 DOI: 10.1007/7854_2011_129  1
2013 Koob GF. Neurobiological Mechanisms of Drug Addiction: An Introduction Biological Research On Addiction. 3-10. DOI: 10.1016/B978-0-12-398335-0.00001-7  1
2013 Pulvirenti L, Moal ML, Koob GF. Psychostimulants and addiction Neuroscience in the 21st Century: From Basic to Clinical. 2731-2743. DOI: 10.1007/978-1-4614-1997-6_106  1
2012 Higley AE, Koob GF, Mason BJ. Treatment of alcohol dependence with drug antagonists of the stress response. Alcohol Research : Current Reviews. 34: 516-21. PMID 23584117  1
2012 George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences of the United States of America. 109: 18156-61. PMID 23071333 DOI: 10.1073/pnas.1116523109  1
2012 Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neuroscience and Biobehavioral Reviews. 36: 2179-92. PMID 22975446 DOI: 10.1016/j.neubiorev.2012.07.010  1
2012 Moreno AY, Azar MR, Koob GF, Janda KD. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine. 30: 6665-70. PMID 22963803 DOI: 10.1016/j.vaccine.2012.08.064  1
2012 Wee S, Vendruscolo LF, Misra KK, Schlosburg JE, Koob GF. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. Science Translational Medicine. 4: 146ra110. PMID 22875830 DOI: 10.1126/scitranslmed.3003948  1
2012 Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7563-71. PMID 22649234 DOI: 10.1523/JNEUROSCI.0069-12.2012  1
2012 Koob GF. Animal models of psychiatric disorders. Handbook of Clinical Neurology. 106: 137-66. PMID 22608620 DOI: 10.1016/B978-0-444-52002-9.00009-7  1
2012 Cohen A, Koob GF, George O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2153-60. PMID 22549121 DOI: 10.1038/npp.2012.67  1
2012 Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology. 223: 159-68. PMID 22526534 DOI: 10.1007/s00213-012-2703-3  1
2012 Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Tignor N, Mezey JG, Crystal RG. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human Gene Therapy. 23: 451-9. PMID 22486244 DOI: 10.1089/hum.2011.178  1
2012 Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology. 223: 17-25. PMID 22418732 DOI: 10.1007/s00213-012-2682-4  1
2012 Mandyam CD, Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends in Neurosciences. 35: 250-60. PMID 22265158 DOI: 10.1016/j.tins.2011.12.005  1
2012 Edwards S, Koob GF. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. Methods in Molecular Biology (Clifton, N.J.). 829: 31-48. PMID 22231805 DOI: 10.1007/978-1-61779-458-2_2  1
2012 Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1275-87. PMID 22205547 DOI: 10.1038/npp.2011.315  1
2012 Koob GF, Zorrilla EP. Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 308-9. PMID 22157874 DOI: 10.1038/npp.2011.213  1
2012 Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism. Neuropharmacology. 62: 1142-51. PMID 22119954 DOI: 10.1016/j.neuropharm.2011.11.006  1
2012 George O, Le Moal M, Koob GF. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiology & Behavior. 106: 58-64. PMID 22108506 DOI: 10.1016/j.physbeh.2011.11.004  1
2012 Lenoir M, Guillem K, Koob GF, Ahmed SH. Drug specificity in extended access cocaine and heroin self-administration. Addiction Biology. 17: 964-76. PMID 21995515 DOI: 10.1111/j.1369-1600.2011.00385.x  1
2012 Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM, Janda KD, Crystal RG, Koob GF. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1083-91. PMID 21918504 DOI: 10.1038/npp.2011.200  1
2012 Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology. 62: 552-64. PMID 21782834 DOI: 10.1016/j.neuropharm.2011.07.007  1
2012 Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Addiction Biology. 17: 300-8. PMID 21762287 DOI: 10.1111/j.1369-1600.2011.00329.x  1
2012 Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addiction Biology. 17: 76-85. PMID 21309953 DOI: 10.1111/j.1369-1600.2010.00291.x  1
2012 Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addiction Biology. 17: 108-20. PMID 21309947 DOI: 10.1111/j.1369-1600.2010.00284.x  1
2011 Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. Developing a vaccine against multiple psychoactive targets: a case study of heroin. Cns & Neurological Disorders Drug Targets. 10: 865-75. PMID 22229311  1
2011 Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. Journal of Medicinal Chemistry. 54: 5195-204. PMID 21692508 DOI: 10.1021/jm200461m  1
2011 Mihindou C, Vouillac C, Koob GF, Ahmed SH. Preclinical validation of a novel cocaine exposure therapy for relapse prevention. Biological Psychiatry. 70: 593-8. PMID 21571256 DOI: 10.1016/j.biopsych.2011.03.036  1
2011 Parylak SL, Koob GF, Zorrilla EP. The dark side of food addiction. Physiology & Behavior. 104: 149-56. PMID 21557958 DOI: 10.1016/j.physbeh.2011.04.063  1
2011 Gilpin NW, Misra K, Herman MA, Cruz MT, Koob GF, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biological Psychiatry. 69: 1091-9. PMID 21459365 DOI: 10.1016/j.biopsych.2011.02.004  1
2011 George O, Koob GF. Craving, context and the cortex. Nature Neuroscience. 14: 409-10. PMID 21445066 DOI: 10.1038/nn.2787  1
2011 Logrip ML, Koob GF, Zorrilla EP. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. Cns Drugs. 25: 271-87. PMID 21425881 DOI: 10.2165/11587790-000000000-00000  1
2011 Vendruscolo LF, Schlosburg JE, Misra KK, Chen SA, Greenwell TN, Koob GF. Escalation patterns of varying periods of heroin access. Pharmacology, Biochemistry, and Behavior. 98: 570-4. PMID 21406200 DOI: 10.1016/j.pbb.2011.03.004  1
2011 Contet C, Gardon O, Filliol D, Becker JA, Koob GF, Kieffer BL. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence. Addiction Biology. 16: 615-9. PMID 21392173 DOI: 10.1111/j.1369-1600.2010.00304.x  1
2011 Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1207-18. PMID 21346735 DOI: 10.1038/npp.2011.5  1
2011 Allen CD, Lee S, Koob GF, Rivier C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain, Behavior, and Immunity. 25: S50-60. PMID 21300146 DOI: 10.1016/j.bbi.2011.01.016  1
2011 Crabbe JC, Harris RA, Koob GF. Preclinical studies of alcohol binge drinking. Annals of the New York Academy of Sciences. 1216: 24-40. PMID 21272009 DOI: 10.1111/j.1749-6632.2010.05895.x  1
2011 Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Toth M, Mezey JG, Crystal RG. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 612-9. PMID 21206484 DOI: 10.1038/mt.2010.280  1
2011 George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology. 213: 715-22. PMID 20924754 DOI: 10.1007/s00213-010-2024-3  1
2011 Walker BM, Zorrilla EP, Koob GF. Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addiction Biology. 16: 116-9. PMID 20579007 DOI: 10.1111/j.1369-1600.2010.00226.x  1
2011 Ali SF, Kim HC, Koob G, Onaivi E, Kuhar MJ. Preface Current Neuropharmacology. 9: 1. DOI: 10.2174/157015911795017272  1
2010 Koob GF. Focus on: Neuroscience and treatment: the potential of neuroscience to inform treatment. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 33: 144-51. PMID 23579944  1
2010 Gilpin NW, Koob GF. Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology. 212: 431-9. PMID 20676608 DOI: 10.1007/s00213-010-1967-8  1
2010 Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurology. 5: 393-401. PMID 20563312 DOI: 10.2217/fnl.10.14  1
2010 Shurman J, Koob GF, Gutstein HB. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Medicine (Malden, Mass.). 11: 1092-8. PMID 20545871 DOI: 10.1111/j.1526-4637.2010.00881.x  1
2010 George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 35: 232-47. PMID 20493211 DOI: 10.1016/j.neubiorev.2010.05.002  1
2010 Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addiction Biology. 15: 312-23. PMID 20456290 DOI: 10.1111/j.1369-1600.2010.00211.x  1
2010 George O, Grieder TE, Cole M, Koob GF. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacology, Biochemistry, and Behavior. 96: 104-7. PMID 20420848 DOI: 10.1016/j.pbb.2010.04.013  1
2010 Wee S, Koob GF. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology. 210: 121-35. PMID 20352414 DOI: 10.1007/s00213-010-1825-8  1
2010 Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discovery Today. 15: 371-83. PMID 20206287 DOI: 10.1016/j.drudis.2010.02.011  1
2010 Moreno AY, Azar MR, Warren NA, Dickerson TJ, Koob GF, Janda KD. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Molecular Pharmaceutics. 7: 431-41. PMID 20104903 DOI: 10.1021/mp900213u  1
2010 Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biological Psychiatry. 67: 831-9. PMID 20060104 DOI: 10.1016/j.biopsych.2009.11.007  1
2010 Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Current Opinion in Investigational Drugs (London, England : 2000). 11: 63-71. PMID 20047160  1
2010 Koob GF. The role of CRF and CRF-related peptides in the dark side of addiction. Brain Research. 1314: 3-14. PMID 19912996 DOI: 10.1016/j.brainres.2009.11.008  1
2010 Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 217-38. PMID 19710631 DOI: 10.1038/npp.2009.110  1
2010 Koob GF. Addiction: Neurobiological mechanism Encyclopedia of Neuroscience. 75-81. DOI: 10.1016/B978-008045046-9.00384-3  1
2009 Koob GF, Simon EJ. The Neurobiology of Addiction: Where We Have Been and Where We Are Going. Journal of Drug Issues. 39: 115-132. PMID 20622969  1
2009 Roberto M, Koob GF. First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding. Alcohol (Fayetteville, N.Y.). 43: 489-90. PMID 19913191 DOI: 10.1016/j.alcohol.2009.10.008  1
2009 Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proceedings of the National Academy of Sciences of the United States of America. 106: 20016-20. PMID 19901333 DOI: 10.1073/pnas.0908789106  1
2009 Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, et al. Genetical genomic determinants of alcohol consumption in rats and humans. Bmc Biology. 7: 70. PMID 19874574 DOI: 10.1186/1741-7007-7-70  1
2009 Gilpin NW, Smith AD, Cole M, Weiss F, Koob GF, Richardson HN. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcoholism, Clinical and Experimental Research. 33: 2113-23. PMID 19740131 DOI: 10.1111/j.1530-0277.2009.01051.x  1
2009 Francesconi W, Berton F, Koob GF, Sanna PP. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Progress in Neuro-Psychopharmacology & Biological Psychiatry. 33: 1347-55. PMID 19683025 DOI: 10.1016/j.pnpbp.2009.08.003  1
2009 Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam CD. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiology of Disease. 36: 1-10. PMID 19501165 DOI: 10.1016/j.nbd.2009.05.021  1
2009 Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology. 205: 565-75. PMID 19484223 DOI: 10.1007/s00213-009-1563-y  1
2009 Koob GF, Kenneth Lloyd G, Mason BJ. Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nature Reviews. Drug Discovery. 8: 500-15. PMID 19483710 DOI: 10.1038/nrd2828  1
2009 Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology. 205: 327-35. PMID 19440699 DOI: 10.1007/s00213-009-1548-x  1
2009 Koob GF. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry. 42: S32-41. PMID 19434554 DOI: 10.1055/s-0029-1216356  1
2009 Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5389-401. PMID 19403807 DOI: 10.1523/JNEUROSCI.5129-08.2009  1
2009 Orio L, Edwards S, George O, Parsons LH, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4846-57. PMID 19369553 DOI: 10.1523/JNEUROSCI.0563-09.2009  1
2009 Koob GF. Brain stress systems in the amygdala and addiction. Brain Research. 1293: 61-75. PMID 19332030 DOI: 10.1016/j.brainres.2009.03.038  1
2009 Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addiction Biology. 14: 130-43. PMID 19291009 DOI: 10.1111/j.1369-1600.2008.00142.x  1
2009 Koob GF. New dimensions in human laboratory models of addiction. Addiction Biology. 14: 1-8. PMID 19133879 DOI: 10.1111/j.1369-1600.2008.00127.x  1
2009 Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1482-93. PMID 18946467 DOI: 10.1038/npp.2008.192  1
2009 Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 56: 18-31. PMID 18725236 DOI: 10.1016/j.neuropharm.2008.07.043  1
2009 Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacology, Biochemistry, and Behavior. 91: 295-302. PMID 18703080 DOI: 10.1016/j.pbb.2008.07.012  1
2008 Koob GF. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discovery Today. Disease Models. 5: 207-215. PMID 20054425 DOI: 10.1016/j.ddmod.2009.04.002  1
2008 Gilpin NW, Koob GF. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 31: 185-95. PMID 19881886  1
2008 Richardson HN, Lee SY, O'Dell LE, Koob GF, Rivier CL. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. The European Journal of Neuroscience. 28: 1641-53. PMID 18979677 DOI: 10.1111/j.1460-9568.2008.06455.x  1
2008 Du X, Schwander M, Moresco EM, Viviani P, Haller C, Hildebrand MS, Pak K, Tarantino L, Roberts A, Richardson H, Koob G, Najmabadi H, Ryan AF, Smith RJ, Müller U, et al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 105: 14609-14. PMID 18794526 DOI: 10.1073/pnas.0807219105  1
2008 Koob GF, Le Moal M. Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3113-23. PMID 18653439 DOI: 10.1098/rstb.2008.0094  1
2008 Gilpin NW, Richardson HN, Cole M, Koob GF. Vapor inhalation of alcohol in rats. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 9.29. PMID 18634001 DOI: 10.1002/0471142301.ns0929s44  1
2008 Gilpin NW, Richardson HN, Koob GF. Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcoholism, Clinical and Experimental Research. 32: 1535-42. PMID 18631323 DOI: 10.1111/j.1530-0277.2008.00745.x  1
2008 Koob GF. A role for brain stress systems in addiction. Neuron. 59: 11-34. PMID 18614026 DOI: 10.1016/j.neuron.2008.06.012  1
2008 Walker BM, Koob GF. Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake". Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2113; author reply 2. PMID 18593720 DOI: 10.1096/fj.08-0702LTR  1
2008 Koob GF. Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism. Proceedings of the National Academy of Sciences of the United States of America. 105: 8809-10. PMID 18583480 DOI: 10.1073/pnas.0804354105  1
2008 Roberto M, Gilpin NW, O'Dell LE, Cruz MT, Morse AC, Siggins GR, Koob GF. Cellular and behavioral interactions of gabapentin with alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5762-71. PMID 18509038 DOI: 10.1523/JNEUROSCI.0575-08.2008  1
2008 Gilpin NW, Misra K, Koob GF. Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacology, Biochemistry, and Behavior. 90: 475-80. PMID 18501411 DOI: 10.1016/j.pbb.2008.04.006  1
2008 Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biological Psychiatry. 64: 958-65. PMID 18490002 DOI: 10.1016/j.biopsych.2008.04.010  1
2008 Gilpin NW, Richardson HN, Lumeng L, Koob GF. Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcoholism, Clinical and Experimental Research. 32: 1688-96. PMID 18482158 DOI: 10.1111/j.1530-0277.2008.00678.x  1
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, ... ... Koob GF, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/j.biopsych.2008.03.005  1
2008 Walker BM, Rasmussen DD, Raskind MA, Koob GF. alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol (Fayetteville, N.Y.). 42: 91-7. PMID 18358987 DOI: 10.1016/j.alcohol.2007.12.002  1
2008 Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2878-87. PMID 18288089 DOI: 10.1038/npp.2008.8  1
2008 Ji D, Gilpin NW, Richardson HN, Rivier CL, Koob GF. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behavioural Pharmacology. 19: 1-12. PMID 18195589 DOI: 10.1097/FBP.0b013e3282f3cf70  1
2008 Koob GF. Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis. Biological Psychiatry. 63: 137-8. PMID 18164903 DOI: 10.1016/j.biopsych.2007.10.005  1
2008 Koob GF, Le Moal M. Addiction and the brain antireward system. Annual Review of Psychology. 59: 29-53. PMID 18154498 DOI: 10.1146/annurev.psych.59.103006.093548  1
2008 George O, Mandyam CD, Wee S, Koob GF. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2474-82. PMID 18033234 DOI: 10.1038/sj.npp.1301626  1
2008 Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology, Biochemistry, and Behavior. 88: 497-510. PMID 18031798 DOI: 10.1016/j.pbb.2007.10.008  1
2008 Specio SE, Wee S, O'Dell LE, Boutrel B, Zorrilla EP, Koob GF. CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology. 196: 473-82. PMID 17965976 DOI: 10.1007/s00213-007-0983-9  1
2008 Wee S, Mandyam CD, Lekic DM, Koob GF. Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 18: 303-11. PMID 17920248 DOI: 10.1016/j.euroneuro.2007.08.003  1
2008 Guillem K, Vouillac C, Koob GF, Cador M, Stinus L. Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion. Biological Psychiatry. 63: 158-63. PMID 17643399 DOI: 10.1016/j.biopsych.2007.04.029  1
2008 Walker BM, Koob GF. Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 643-52. PMID 17473837 DOI: 10.1038/sj.npp.1301438  1
2008 Koob GF. The role of animal models in reward deficit disorders: Views from academia Animal and Translational Models For Cns Drug Discovery. 3: 59-89. DOI: 10.1016/B978-0-12-373861-5.00024-2  1
2007 Koob GF, Miller SC, Wunsch MJ. Inaugural issue of the journal of addiction medicine. Journal of Addiction Medicine. 1: 1. PMID 21768924 DOI: 10.1097/ADM.0b013e318033d5bf  1
2007 Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13140-50. PMID 18045908 DOI: 10.1523/JNEUROSCI.2284-07.2007  1
2007 Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11442-50. PMID 17942739 DOI: 10.1523/JNEUROSCI.2505-07.2007  1
2007 George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences of the United States of America. 104: 17198-203. PMID 17921249 DOI: 10.1073/pnas.0707585104  1
2007 Zhang Z, Morse AC, Koob GF, Schulteis G. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcoholism, Clinical and Experimental Research. 31: 1811-9. PMID 17877783 DOI: 10.1111/j.1530-0277.2007.00483.x  1
2007 Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. The American Journal of Psychiatry. 164: 1149-59. PMID 17671276 DOI: 10.1176/appi.ajp.2007.05030503  1
2007 Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences. 30: 399-406. PMID 17629579 DOI: 10.1016/j.tins.2007.06.006  1
2007 Treweek J, Wee S, Koob GF, Dickerson TJ, Janda KD. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 11580-4. PMID 17592122 DOI: 10.1073/pnas.0701328104  1
2007 Funk CK, Koob GF. A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Research. 1155: 172-8. PMID 17512918 DOI: 10.1016/j.brainres.2007.04.009  1
2007 Chu K, Koob GF, Cole M, Zorrilla EP, Roberts AJ. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacology, Biochemistry, and Behavior. 86: 813-21. PMID 17482248 DOI: 10.1016/j.pbb.2007.03.009  1
2007 Thorsell A, Repunte-Canonigo V, O'Dell LE, Chen SA, King AR, Lekic D, Koob GF, Sanna PP. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain : a Journal of Neurology. 130: 1330-7. PMID 17405766 DOI: 10.1093/brain/awm033  1
2007 Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol. Journal of the American Chemical Society. 129: 3698-702. PMID 17335216 DOI: 10.1021/ja070022m  1
2007 Wee S, Wang Z, Woolverton WL, Pulvirenti L, Koob GF. Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2238-47. PMID 17327886 DOI: 10.1038/sj.npp.1301353  1
2007 O'Dell LE, Koob GF. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. Pharmacology, Biochemistry, and Behavior. 86: 346-53. PMID 17292952 DOI: 10.1016/j.pbb.2007.01.004  1
2007 Walker BM, Koob GF. The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcoholism, Clinical and Experimental Research. 31: 11-8. PMID 17207096 DOI: 10.1111/j.1530-0277.2006.00259.x  1
2007 Wee S, Specio SE, Koob GF. Effects of dose and session duration on cocaine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 1134-43. PMID 17202405 DOI: 10.1124/jpet.106.113340  1
2007 Le Moal M, Koob GF. Drug addiction: pathways to the disease and pathophysiological perspectives. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 377-93. PMID 17169534 DOI: 10.1016/j.euroneuro.2006.10.006  1
2007 Solbrig MV, Adrian R, Wechsler SL, Koob GF. Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. European Journal of Pharmacology. 555: 23-9. PMID 17126318 DOI: 10.1016/j.ejphar.2006.10.025  1
2007 O'Dell LE, Chen SA, Smith RT, Specio SE, Balster RL, Paterson NE, Markou A, Zorrilla EP, Koob GF. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 180-93. PMID 17050784 DOI: 10.1124/jpet.106.105270  1
2007 Fekete EM, Inoue K, Zhao Y, Rivier JE, Vale WW, Szücs A, Koob GF, Zorrilla EP. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1052-68. PMID 17019404 DOI: 10.1038/sj.npp.1301214  1
2007 Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biological Psychiatry. 61: 78-86. PMID 16876134 DOI: 10.1016/j.biopsych.2006.03.063  1
2006 Heinrichs SC, Koob GF. Application of experimental stressors in laboratory rodents. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit8.4. PMID 18428648 DOI: 10.1002/0471142301.ns0804s34  1
2006 Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. The European Journal of Neuroscience. 24: 3532-40. PMID 17229101 DOI: 10.1111/j.1460-9568.2006.05217.x  1
2006 O'Brien CP, Koob GF, Mee-Lee D, Rosenthal RN. New developments in addiction treatment. The Journal of Clinical Psychiatry. 67: 1801-12. PMID 17196062  1
2006 Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ, Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Molecular Pharmaceutics. 3: 773-7. PMID 17140265 DOI: 10.1021/mp060066m  1
2006 Funk CK, O'Dell LE, Crawford EF, Koob GF. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11324-32. PMID 17079660 DOI: 10.1523/JNEUROSCI.3096-06.2006  1
2006 Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology. 189: 175-86. PMID 17047935 DOI: 10.1007/s00213-006-0546-5  1
2006 Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF. Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology. 11: 195-269. PMID 16961758 DOI: 10.1111/j.1369-1600.2006.00038.x  1
2006 Koob GF. The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction (Abingdon, England). 101: 23-30. PMID 16930158 DOI: 10.1111/j.1360-0443.2006.01586.x  1
2006 Steffensen SC, Stobbs SH, Colago EE, Lee RS, Koob GF, Gallegos RA, Henriksen SJ. Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons. Experimental Neurology. 202: 139-51. PMID 16814775 DOI: 10.1016/j.expneurol.2006.05.023  1
2006 Kenny PJ, Chen SA, Kitamura O, Markou A, Koob GF. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5894-900. PMID 16738231 DOI: 10.1523/JNEUROSCI.0740-06.2006  1
2006 Hoefer ME, Voskanian SJ, Koob GF, Pulvirenti L. Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat. Pharmacology, Biochemistry, and Behavior. 83: 403-9. PMID 16647107 DOI: 10.1016/j.pbb.2006.02.023  0.88
2006 Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 6368-73. PMID 16618939 DOI: 10.1073/pnas.0510188103  1
2006 O'Dell LE, Bruijnzeel AW, Smith RT, Parsons LH, Merves ML, Goldberger BA, Richardson HN, Koob GF, Markou A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology. 186: 612-9. PMID 16598454 DOI: 10.1007/s00213-006-0383-6  1
2006 Kitamura O, Wee S, Specio SE, Koob GF, Pulvirenti L. Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology. 186: 48-53. PMID 16552556 DOI: 10.1007/s00213-006-0353-z  0.88
2006 Johnson BA, Koob GF, Schuckit MA, Mason BJ, Ait-Daoud N. Understanding and treating alcohol dependence. Alcoholism, Clinical and Experimental Research. 30: 567-84. PMID 16499499 DOI: 10.1111/j.1530-0277.2005.00066.x  1
2006 Chen SA, O'Dell LE, Hoefer ME, Greenwell TN, Zorrilla EP, Koob GF. Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2692-707. PMID 16452993 DOI: 10.1038/sj.npp.1301008  1
2006 Kranzler HR, Koob G, Gastfriend DR, Swift RM, Willenbring ML. Advances in the pharmacotherapy of alcoholism: challenging misconceptions. Alcoholism, Clinical and Experimental Research. 30: 272-81. PMID 16441276 DOI: 10.1111/j.1530-0277.2006.00022.x  1
2006 Solbrig MV, Adrian R, Baratta J, Lauterborn JC, Koob GF. Kappa opioid control of seizures produced by a virus in an animal model. Brain : a Journal of Neurology. 129: 642-54. PMID 16399805 DOI: 10.1093/brain/awl008  1
2006 Koob GF. A Role for GABA in Alcohol Dependence1 Advances in Pharmacology. 54: 205-229. DOI: 10.1016/S1054-3589(06)54009-8  1
2006 Koob GF. Finding our niche Pharmacology Biochemistry and Behavior. 84: 1-2. DOI: 10.1016/j.pbb.2006.06.006  1
2005 Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 19168-73. PMID 16357203 DOI: 10.1073/pnas.0507480102  1
2005 Qi L, Yamamoto N, Meijler MM, Altobell LJ, Koob GF, Wirsching P, Janda KD. Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol. Journal of Medicinal Chemistry. 48: 7389-99. PMID 16279798 DOI: 10.1021/jm050442r  1
2005 Koob GF, Le Moal M. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nature Neuroscience. 8: 1442-4. PMID 16251985 DOI: 10.1038/nn1105-1442  1
2005 Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8593-600. PMID 16177026 DOI: 10.1523/JNEUROSCI.2139-05.2005  1
2005 Sanchis-Segura C, Grisel JE, Olive MF, Ghozland S, Koob GF, Roberts AJ, Cowen MS. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question. Alcoholism, Clinical and Experimental Research. 29: 1522-7. PMID 16156049 DOI: 10.1097/01.alc.0000174913.60384.e8  1
2005 Ahmed SH, Lutjens R, van der Stap LD, Lekic D, Romano-Spica V, Morales M, Koob GF, Repunte-Canonigo V, Sanna PP. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proceedings of the National Academy of Sciences of the United States of America. 102: 11533-8. PMID 16076954 DOI: 10.1073/pnas.0504438102  1
2005 Izzo E, Sanna PP, Koob GF. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor. Pharmacology, Biochemistry, and Behavior. 81: 701-8. PMID 16005056 DOI: 10.1016/j.pbb.2005.04.017  0.72
2005 O'Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacology, Biochemistry, and Behavior. 81: 543-50. PMID 15950269 DOI: 10.1016/j.pbb.2005.03.020  1
2005 Ahmed SH, Koob GF. Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology. 180: 473-90. PMID 15731896 DOI: 10.1007/s00213-005-2180-z  1
2005 Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF, Lê DA, O'Dell LE, Overstreet DH, Roberts AJ, Sinha R, Valdez GR, Weiss F. Stress enhancement of craving during sobriety: a risk for relapse. Alcoholism, Clinical and Experimental Research. 29: 185-95. PMID 15714042 DOI: 10.1097/01.ALC.0000153544.83656.3C  1
2005 Zorrilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF. Measuring meals: structure of prandial food and water intake of rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1450-67. PMID 15637168 DOI: 10.1152/ajpregu.00175.2004  1
2005 Zorrilla EP, Inoue K, Valdez GR, Tabarin A, Koob GF. Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology. 177: 324-35. PMID 15609069 DOI: 10.1007/s00213-004-1952-1  1
2005 Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology. 179: 247-54. PMID 15602687 DOI: 10.1007/s00213-004-2069-2  1
2005 Stinus L, Cador M, Zorrilla EP, Koob GF. Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 90-8. PMID 15138444 DOI: 10.1038/sj.npp.1300487  1
2005 Koob GF. The neurocircuitry of addiction: Implications for treatment Clinical Neuroscience Research. 5: 89-101. DOI: 10.1016/j.cnr.2005.08.005  1
2005 Boutrel B, Kenny PJ, Markou A, Koob GF. Hypocretin and brain reward function Hypocretins: Integrators of Physiological Functions. 317-326. DOI: 10.1007/0-387-25446-3_21  1
2004 Valdez GR, Koob GF. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacology, Biochemistry, and Behavior. 79: 671-89. PMID 15582675 DOI: 10.1016/j.pbb.2004.09.020  1
2004 O'Dell LE, Roberts AJ, Smith RT, Koob GF. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcoholism, Clinical and Experimental Research. 28: 1676-82. PMID 15547454 DOI: 10.1097/01.ALC.0000145781.11923.4E  1
2004 Boutrel B, Koob GF. What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep. 27: 1181-94. PMID 15532213  1
2004 Navarro M, Carrera MR, Del Arco I, Trigo JM, Koob GF, Rodríguez de Fonseca F. Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats. European Journal of Pharmacology. 501: 235-7. PMID 15464083 DOI: 10.1016/j.ejphar.2004.08.022  0.64
2004 Koob GF. A role for GABA mechanisms in the motivational effects of alcohol. Biochemical Pharmacology. 68: 1515-25. PMID 15451394 DOI: 10.1016/j.bcp.2004.07.031  1
2004 Koob GF, Greenwell TN. Neuropeptide S: a novel activating anxiolytic? Neuron. 43: 441-2. PMID 15312642 DOI: 10.1016/j.neuron.2004.08.007  1
2004 Heinrichs SC, Koob GF. Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. The Journal of Pharmacology and Experimental Therapeutics. 311: 427-40. PMID 15297468 DOI: 10.1124/jpet.103.052092  1
2004 Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 311: 265-73. PMID 15263066 DOI: 10.1124/jpet.104.067504  1
2004 O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF. Nicotine withdrawal in adolescent and adult rats. Annals of the New York Academy of Sciences. 1021: 167-74. PMID 15251887 DOI: 10.1196/annals.1308.022  1
2004 Carrera MR, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. Treating cocaine addiction with viruses. Proceedings of the National Academy of Sciences of the United States of America. 101: 10416-21. PMID 15226496 DOI: 10.1073/pnas.0403795101  0.92
2004 Zorrilla EP, Koob GF. The therapeutic potential of CRF1 antagonists for anxiety. Expert Opinion On Investigational Drugs. 13: 799-828. PMID 15212620 DOI: 10.1517/13543784.13.7.799  1
2004 Valdez GR, Sabino V, Koob GF. Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. Alcoholism, Clinical and Experimental Research. 28: 865-72. PMID 15201629  1
2004 Koob GF. Allostatic view of motivation: implications for psychopathology. Nebraska Symposium On Motivation. Nebraska Symposium On Motivation. 50: 1-18. PMID 15160636  1
2004 Inoue K, Zorrilla EP, Tabarin A, Valdez GR, Iwasaki S, Kiriike N, Koob GF. Reduction of anxiety after restricted feeding in the rat: implication for eating disorders. Biological Psychiatry. 55: 1075-81. PMID 15158426 DOI: 10.1016/j.biopsych.2004.01.026  1
2004 Zorrilla EP, Reinhardt LE, Valdez GR, Inoue K, Rivier JE, Vale WW, Koob GF. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. The Journal of Pharmacology and Experimental Therapeutics. 310: 1027-34. PMID 15115804 DOI: 10.1124/jpet.104.068676  1
2004 Solbrig MV, Koob GF. Epilepsy, CNS viral injury and dynorphin. Trends in Pharmacological Sciences. 25: 98-104. PMID 15102496 DOI: 10.1016/j.tips.2003.12.010  1
2004 Sanna PP, Koob GF. Cocaine's long run. Nature Medicine. 10: 340-1. PMID 15057223 DOI: 10.1038/nm0404-340  1
2004 Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, Parsons LH, Sanna PP. Neurobiological mechanisms in the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 27: 739-49. PMID 15019424 DOI: 10.1016/j.neubiorev.2003.11.007  1
2004 Weed MR, Gold LH, Polis I, Koob GF, Fox HS, Taffe MA. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection. Aids Research and Human Retroviruses. 20: 77-89. PMID 15000701 DOI: 10.1089/088922204322749521  1
2004 O'Dell LE, Alomary AA, Vallée M, Koob GF, Fitzgerald RL, Purdy RH. Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats. European Journal of Pharmacology. 484: 241-7. PMID 14744609 DOI: 10.1016/j.ejphar.2003.11.031  1
2004 Carrera MR, Ashley JA, Hoffman TZ, Isomura S, Wirsching P, Koob GF, Janda KD. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorganic & Medicinal Chemistry. 12: 563-70. PMID 14738965  0.92
2004 Ahmed SH, Koob GF. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology. 172: 450-4. PMID 14647962 DOI: 10.1007/s00213-003-1682-9  1
2004 Ben-Shahar O, Ahmed SH, Koob GF, Ettenberg A. The transition from controlled to compulsive drug use is associated with a loss of sensitization. Brain Research. 995: 46-54. PMID 14644470 DOI: 10.1016/j.brainres.2003.09.053  1
2003 Koob GF. Neuroadaptive mechanisms of addiction: studies on the extended amygdala. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 442-52. PMID 14636960 DOI: 10.1016/j.euroneuro.2003.08.005  1
2003 Kenny PJ, Koob GF, Markou A. Conditioned facilitation of brain reward function after repeated cocaine administration. Behavioral Neuroscience. 117: 1103-7. PMID 14570559 DOI: 10.1037/0735-7044.117.5.1103  1
2003 Vallée M, Purdy RH, Mayo W, Koob GF, Le Moal M. Neuroactive steroids: new biomarkers of cognitive aging. The Journal of Steroid Biochemistry and Molecular Biology. 85: 329-35. PMID 12943719 DOI: 10.1016/S0960-0760(03)00227-9  1
2003 Zorrilla EP, Taché Y, Koob GF. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends in Pharmacological Sciences. 24: 421-7. PMID 12915052 DOI: 10.1016/S0165-6147(03)00177-9  1
2003 Walker JR, Chen SA, Moffitt H, Inturrisi CE, Koob GF. Chronic opioid exposure produces increased heroin self-administration in rats. Pharmacology, Biochemistry, and Behavior. 75: 349-54. PMID 12873626 DOI: 10.1016/S0091-3057(03)00094-7  1
2003 Valdez GR, Zorrilla EP, Rivier J, Vale WW, Koob GF. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist. Brain Research. 980: 206-12. PMID 12867260 DOI: 10.1016/S0006-8993(03)02971-8  1
2003 Ahmed SH, Lin D, Koob GF, Parsons LH. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of Neurochemistry. 86: 102-13. PMID 12807430 DOI: 10.1046/j.1471-4159.2003.01833.x  1
2003 Valdez GR, Zorrilla EP, Roberts AJ, Koob GF. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol (Fayetteville, N.Y.). 29: 55-60. PMID 12782246 DOI: 10.1016/S0741-8329(03)00020-X  1
2003 Heyser CJ, Moc K, Koob GF. Effects of naltrexone alone and in combination with acamprosate on the alcohol deprivation effect in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1463-71. PMID 12700689 DOI: 10.1038/sj.npp.1300175  0.72
2003 Solbrig MV, Koob GF. Neuropharmacological sequelae of persistent CNS viral infections: lessons from Borna disease virus. Pharmacology, Biochemistry, and Behavior. 74: 777-87. PMID 12667891 DOI: 10.1016/S0091-3057(03)00019-4  1
2003 Inoue K, Valdez GR, Reyes TM, Reinhardt LE, Tabarin A, Rivier J, Vale WW, Sawchenko PE, Koob GF, Zorrilla EP. Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat. The Journal of Pharmacology and Experimental Therapeutics. 305: 385-93. PMID 12649393 DOI: 10.1124/jpet.102.047712  1
2003 Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R, Weiss F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Developments in Alcoholism : An Official Publication of the American Medical Society On Alcoholism, the Research Society On Alcoholism, and the National Council On Alcoholism. 16: 263-81. PMID 12638642  1
2003 Koob GF. Alcoholism: allostasis and beyond. Alcoholism, Clinical and Experimental Research. 27: 232-43. PMID 12605072 DOI: 10.1097/01.ALC.0000057122.36127.C2  1
2003 Caillé S, Stinus L, Espejo EF, De Deurwaerdère P, Spampinato U, Koob GF. Inhibition of 5-HT neurotransmission increases clonidine protective effects on naloxone-induced conditioned place aversion in morphine-dependent rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 276-83. PMID 12589380 DOI: 10.1038/sj.npp.1300033  1
2003 Kenny PJ, Polis I, Koob GF, Markou A. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. The European Journal of Neuroscience. 17: 191-5. PMID 12534985 DOI: 10.1046/j.1460-9568.2003.02443.x  1
2002 Izzo E, Martin-Fardon R, Koob GF, Weiss F, Sanna PP. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nature Neuroscience. 5: 1263-4. PMID 12436114 DOI: 10.1038/nn977  1
2002 Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, Koob GF. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcoholism, Clinical and Experimental Research. 26: 1494-501. PMID 12394282 DOI: 10.1097/01.ALC.0000033120.51856.F0  1
2002 Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Research. 952: 188-99. PMID 12376179 DOI: 10.1016/S0006-8993(02)03189-X  1
2002 Contarino A, Picetti R, Matthes HW, Koob GF, Kieffer BL, Gold LH. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. European Journal of Pharmacology. 446: 103-9. PMID 12098591 DOI: 10.1016/S0014-2999(02)01812-5  1
2002 Walker JR, Terenius L, Koob GF. Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 203-11. PMID 12093594 DOI: 10.1016/S0893-133X(02)00292-0  0.8
2002 Valdez GR, Inoue K, Koob GF, Rivier J, Vale W, Zorrilla EP. Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide. Brain Research. 943: 142-50. PMID 12088848 DOI: 10.1016/S0006-8993(02)02707-5  1
2002 Caillé S, Espejo EF, Koob GF, Stinus L. Dorsal and median raphe serotonergic system lesion does not alter the opiate withdrawal syndrome. Pharmacology, Biochemistry, and Behavior. 72: 979-86. PMID 12062589 DOI: 10.1016/S0091-3057(02)00810-9  0.84
2002 Ahmed SH, Kenny PJ, Koob GF, Markou A. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nature Neuroscience. 5: 625-6. PMID 12055635 DOI: 10.1038/nn872  1
2002 Ryabinin AE, Bachtell RK, Heinrichs SC, Lee S, Rivier C, Olive MF, Mehmert KK, Camarini R, Kim JA, Koenig HN, Nannini MA, Hodge CW, Roberts AJ, Koob GF. The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism, Clinical and Experimental Research. 26: 714-22. PMID 12045481  1
2002 Pulvirenti L, Koob GF. Being partial to psychostimulant addiction therapy. Trends in Pharmacological Sciences. 23: 151-3. PMID 11931978 DOI: 10.1016/S0165-6147(00)01991-X  1
2002 Orsini C, Izzo E, Koob GF, Pulvirenti L. Blockade of nitric oxide synthesis reduces responding for cocaine self-administration during extinction and reinstatement. Brain Research. 925: 133-40. PMID 11792361 DOI: 10.1016/S0006-8993(01)03267-X  1
2001 Weiss F, Koob GF. Drug addiction: functional neurotoxicity of the brain reward systems. Neurotoxicity Research. 3: 145-56. PMID 15111266 DOI: 10.1007/BF03033235  1
2001 Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. The European Journal of Neuroscience. 14: 2003-10. PMID 11860495 DOI: 10.1046/j.0953-816X.2001.01817.x  1
2001 Orsini C, Koob GF, Pulvirenti L. Dopamine partial agonist reverses amphetamine withdrawal in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: 789-92. PMID 11682262 DOI: 10.1016/S0893-133X(01)00270-6  1
2001 Vallée M, Mayo W, Koob GF, Le Moal M. Neurosteroids in learning and memory processes. International Review of Neurobiology. 46: 273-320. PMID 11599303 DOI: 10.1016/S0074-7742(01)46066-1  1
2001 Izzo E, Orsini C, Koob GF, Pulvirenti L. A dopamine partial agonist and antagonist block amphetamine self-administration in a progressive ratio schedule. Pharmacology, Biochemistry, and Behavior. 68: 701-8. PMID 11526967 DOI: 10.1016/S0091-3057(01)00472-5  1
2001 Navarro M, Carrera MR, Fratta W, Valverde O, Cossu G, Fattore L, Chowen JA, Gomez R, del Arco I, Villanua MA, Maldonado R, Koob GF, Rodriguez de Fonseca F. Functional interaction between opioid and cannabinoid receptors in drug self-administration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 5344-50. PMID 11438610  0.64
2001 Lê AD, Kiianmaa K, Cunningham CL, Engel JA, Ericson M, Söderpalm B, Koob GF, Roberts AJ, Weiss F, Hyytiä P, Janhunen S, Mikkola J, Bäckström P, Ponomarev I, Crabbe JC. Neurobiological processes in alcohol addiction. Alcoholism, Clinical and Experimental Research. 25: 144S-151S. PMID 11391064 DOI: 10.1111/J.1530-0277.2001.TB02389.X  1
2001 Zorrilla EP, Schulteis G, Ling N, Koob GF, De Souza EB. Performance-enhancing effects of CRF-BP ligand inhibitors. Neuroreport. 12: 1231-4. PMID 11338197 DOI: 10.1097/00001756-200105080-00035  1
2001 Macey DJ, Froestl W, Koob GF, Markou A. Both GABA(B) receptor agonist and antagonists decreased brain stimulation reward in the rat. Neuropharmacology. 40: 676-85. PMID 11311895 DOI: 10.1016/S0028-3908(00)00204-5  1
2001 Carrera MR, Ashley JA, Wirsching P, Koob GF, Janda KD. A second-generation vaccine protects against the psychoactive effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 98: 1988-92. PMID 11172063 DOI: 10.1073/pnas.041610998  0.92
2001 David V, Gold LH, Koob GF, Cazala P. Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 300-18. PMID 11166520 DOI: 10.1016/S0893-133X(00)00205-0  1
2001 Gracy KN, Dankiewicz LA, Koob GF. Opiate withdrawal-induced fos immunoreactivity in the rat extended amygdala parallels the development of conditioned place aversion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 152-60. PMID 11120397 DOI: 10.1016/S0893-133X(00)00186-X  0.68
2001 Koob GF, Le Moal M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 97-129. PMID 11120394 DOI: 10.1016/S0893-133X(00)00195-0  1
2000 Contarino A, Dellu FO, Koob GF, Smith GW, Lee K, Vale WW, Gold LH. Dissociation of Locomotor Activation and Suppression of Food Intake Induced by CRF in CRFR1-Deficient Mice. Endocrinology. 141: 2698-2702. PMID 28200977 DOI: 10.1210/endo.141.7.7653  1
2000 Morse AC, Schulteis G, Holloway FA, Koob GF. Conditioned place aversion to the "hangover" phase of acute ethanol administration in the rat. Alcohol (Fayetteville, N.Y.). 22: 19-24. PMID 11109024 DOI: 10.1016/S0741-8329(00)00099-9  1
2000 Watkins SS, Koob GF, Markou A. Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 2: 19-37. PMID 11072438 DOI: 10.1080/14622200050011277  1
2000 Smith AD, Smith DL, Zigmond MJ, Amalric M, Koob GF. Differential effects of dopamine receptor subtype blockade on performance of rats in a reaction-time paradigm. Psychopharmacology. 148: 355-60. PMID 10928307 DOI: 10.1007/s002130050063  1
2000 Koob GF. Neurobiology of addiction. Toward the development of new therapies. Annals of the New York Academy of Sciences. 909: 170-85. PMID 10911930 DOI: 10.1111/j.1749-6632.2000.tb06682.x  1
2000 Schulteis G, Ahmed SH, Morse AC, Koob GF, Everitt BJ. Conditioning and opiate withdrawal. Nature. 405: 1013-4. PMID 10890431 DOI: 10.1038/35016630  1
2000 Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale WW, Gold LH. Dissociation of locomotor activation and suppression of food intake induced by CRF in CRFR1-deficient mice. Endocrinology. 141: 2698-702. PMID 10875276 DOI: 10.1210/endo.141.7.7653  1
2000 Macey DJ, Koob GF, Markou A. CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist. Brain Research. 866: 82-91. PMID 10825483 DOI: 10.1016/S0006-8993(00)02229-0  1
2000 Carrera MR, Ashley JA, Zhou B, Wirsching P, Koob GF, Janda KD. Cocaine vaccines: antibody protection against relapse in a rat model. Proceedings of the National Academy of Sciences of the United States of America. 97: 6202-6. PMID 10823960  0.92
2000 Stinus L, Caille S, Koob GF. Opiate withdrawal-induced place aversion lasts for up to 16 weeks. Psychopharmacology. 149: 115-20. PMID 10805605 DOI: 10.1007/s002139900358  1
2000 Roberts AJ, Heyser CJ, Cole M, Griffin P, Koob GF. Excessive ethanol drinking following a history of dependence: animal model of allostasis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 581-94. PMID 10788758 DOI: 10.1016/S0893-133X(99)00167-0  0.84
2000 Walker JR, Ahmed SH, Gracy KN, Koob GF. Microinjections of an opiate receptor antagonist into the bed nucleus of the stria terminalis suppress heroin self-administration in dependent rats. Brain Research. 854: 85-92. PMID 10784110 DOI: 10.1016/S0006-8993(99)02288-X  1
2000 Bale TL, Contarino A, Smith GW, Chan R, Gold LH, Sawchenko PE, Koob GF, Vale WW, Lee KF. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nature Genetics. 24: 410-4. PMID 10742108 DOI: 10.1038/74263  1
2000 Britton KT, Akwa Y, Spina MG, Koob GF. Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze. Peptides. 21: 37-44. PMID 10704717 DOI: 10.1016/S0196-9781(99)00169-2  0.68
2000 Ahmed SH, Walker JR, Koob GF. Persistent increase in the motivation to take heroin in rats with a history of drug escalation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 413-21. PMID 10700660 DOI: 10.1016/S0893-133X(99)00133-5  1
2000 Dellu F, Contarino A, Simon H, Koob GF, Gold LH. Genetic differences in response to novelty and spatial memory using a two-trial recognition task in mice. Neurobiology of Learning and Memory. 73: 31-48. PMID 10686122 DOI: 10.1006/nlme.1999.3919  1
2000 Gracy KN, Dankiewicz LA, Weiss F, Koob GF. Heroin-specific stimuli reinstate operant heroin-seeking behavior in rats after prolonged extinction. Pharmacology, Biochemistry, and Behavior. 65: 489-94. PMID 10683489 DOI: 10.1016/S0091-3057(99)00234-8  1
2000 Lin D, Koob GF, Markou A. Time-dependent alterations in ICSS thresholds associated with repeated amphetamine administrations. Pharmacology, Biochemistry, and Behavior. 65: 407-17. PMID 10683480 DOI: 10.1016/S0091-3057(99)00213-0  1
1999 Schulteis G, Heyser CJ, Koob GF. Differential expression of response-disruptive and somatic indices of opiate withdrawal during the initiation and development of opiate dependence. Behavioural Pharmacology. 10: 235-42. PMID 10780239 DOI: 10.1097/00008877-199905000-00001  1
1999 Koob GF. Stress, corticotropin-releasing factor, and drug addiction Annals of the New York Academy of Sciences. 897: 27-45. PMID 10676433 DOI: 10.1111/j.1749-6632.1999.tb07876.x  1
1999 Koob GF, Heinrichs SC. A role for corticotropin releasing factor and urocortin in behavioral responses to stressors. Brain Research. 848: 141-52. PMID 10612706 DOI: 10.1016/S0006-8993(99)01991-5  1
1999 Koob GF. Cocaine reward and dopamine receptors: Love at first site Archives of General Psychiatry. 56: 1107-1108. PMID 10591287 DOI: 10.1001/ARCHPSYC.56.12.1107  1
1999 Walker JR, King M, Izzo E, Koob GF, Pasternak GW. Antagonism of heroin and morphine self-administration in rats by the morphine-6β-glucuronide antagonist 3-O-methylnaltrexone European Journal of Pharmacology. 383: 115-119. PMID 10585524 DOI: 10.1016/S0014-2999(99)00633-0  1
1999 Koob GF. Corticotropin-releasing factor, norepinephrine, and stress Biological Psychiatry. 46: 1167-1180. PMID 10560023 DOI: 10.1016/S0006-3223(99)00164-X  1
1999 Weed MR, Taffe MA, Polis I, Roberts AC, Robbins TW, Koob GF, Bloom FE, Gold LH. Performance norms for a rhesus monkey neuropsychological testing battery: acquisition and long-term performance. Brain Research. Cognitive Brain Research. 8: 185-201. PMID 10556598 DOI: 10.1016/S0926-6410(99)00020-8  1
1999 Ahmed SH, Koob GF. Long-lasting increase in the set point for cocaine self-administration after escalation in rats. Psychopharmacology. 146: 303-12. PMID 10541731 DOI: 10.1007/s002130051121  1
1999 Lin D, Koob GF, Markou A. Differential effects of withdrawal from chronic amphetamine or fluoxetine administration on brain stimulation reward in the rat--interactions between the two drugs. Psychopharmacology. 145: 283-94. PMID 10494577 DOI: 10.1007/s002130051060  1
1999 Koob GF, Caine SB. Cocaine addiction therapy - Are we partially there? Nature Medicine. 5: 993-995. PMID 10470073 DOI: 10.1038/12429  1
1999 Contarino A, Dellu F, Koob GF, Smith GW, Lee KF, Vale W, Gold LH. Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1. Brain Research. 835: 1-9. PMID 10448190 DOI: 10.1016/S0006-8993(98)01158-5  1
1999 Basso AM, Spina M, Rivier J, Vale W, Koob GF. Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology. 145: 21-30. PMID 10445369 DOI: 10.1007/s002130051028  1
1999 Koob GF. The role of the striatopallidal and extended amygdala systems in drug addiction Annals of the New York Academy of Sciences. 877: 445-460. PMID 10415664 DOI: 10.1111/j.1749-6632.1999.tb09282.x  1
1999 Carrera MR, Schulteis G, Koob GF. Heroin self-administration in dependent Wistar rats: increased sensitivity to naloxone. Psychopharmacology. 144: 111-20. PMID 10394991 DOI: 10.1007/s002130050983  1
1999 Lee RS, Criado JR, Koob GF, Henriksen SJ. Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration. Synapse (New York, N.Y.). 33: 49-58. PMID 10380850 DOI: 10.1002/(SICI)1098-2396(199907)33:1<49::AID-SYN5>3.0.CO;2-O  1
1999 Parsons LH, Koob GF, Weiss F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse (New York, N.Y.). 32: 132-5. PMID 10231132 DOI: 10.1002/(SICI)1098-2396(199905)32:2<132::AID-SYN6>3.0.CO;2-V  1
1999 Leshner AI, Koob GF. Drugs of abuse and the brain Proceedings of the Association of American Physicians. 111: 99-108. PMID 10220804 DOI: 10.1046/J.1525-1381.1999.09218.X  1
1999 Watkins SS, Epping-Jordan MP, Koob GF, Markou A. Blockade of nicotine self-administration with nicotinic antagonists in rats. Pharmacology, Biochemistry, and Behavior. 62: 743-51. PMID 10208381 DOI: 10.1016/S0091-3057(98)00226-3  1
1999 Baldo BA, Jain K, Veraldi L, Koob GF, Markou A. A dopamine D1 agonist elevates self-stimulation thresholds: comparison to other dopamine-selective drugs. Pharmacology, Biochemistry, and Behavior. 62: 659-72. PMID 10208371 DOI: 10.1016/S0091-3057(98)00206-8  1
1999 Harrison AA, Parsons LH, Koob GF, Markou A. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist. Psychopharmacology. 141: 242-50. PMID 10027505 DOI: 10.1007/s002130050831  1
1999 Baldo BA, Markou A, Koob GF. Increased sensitivity to the locomotor depressant effect of a dopamine receptor antagonist during cocaine withdrawal in the rat. Psychopharmacology. 141: 135-44. PMID 9952037 DOI: 10.1007/s002130050817  1
1998 Kosten TR, Markou A, Koob GF. Depression and stimulant dependence: neurobiology and pharmacotherapy. The Journal of Nervous and Mental Disease. 186: 737-45. PMID 9865811 DOI: 10.1097/00005053-199812000-00001  1
1998 Navarro M, Chowen J, Rocío A Carrera M, Del Arco L, Villanúa MA, Martin Y, Roberts AJ, Koob GF, Rodriguez De Fonseca F. CB1 cannabinoid receptor antagonist-induced opiate withdrawal in morphine-dependent rats Neuroreport. 9: 3397-3402. PMID 9855288 DOI: 10.1097/00001756-199810260-00012  1
1998 Kimes AS, Maldonado R, Ambrosio E, Koob GF, London ED. Cerebral glucose metabolism during opioid withdrawal following methylnaloxonium injection into the locus coeruleus. Brain Research. 814: 1-12. PMID 9838021 DOI: 10.1016/S0006-8993(98)00813-0  1
1998 Schulteis G, Stinus L, Risbrough VB, Koob GF. Clonidine blocks acquisition but not expression of conditioned opiate withdrawal in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 406-16. PMID 9778662 DOI: 10.1016/S0893-133X(98)00036-0  1
1998 Koob GF, Sanna PP, Bloom FE. Neuroscience of addiction. Neuron. 21: 467-76. PMID 9768834 DOI: 10.1016/S0896-6273(00)80557-7  1
1998 Ahmed SH, Koob GF. Transition from moderate to excessive drug intake: change in hedonic set point. Science (New York, N.Y.). 282: 298-300. PMID 9765157 DOI: 10.1126/science.282.5387.298  1
1998 Eckardt MJ, File SE, Gessa GL, Grant KA, Guerri C, Hoffman PL, Kalant H, Koob GF, Li TK, Tabakoff B. Effects of moderate alcohol consumption on the central nervous system. Alcoholism, Clinical and Experimental Research. 22: 998-1040. PMID 9726269 DOI: 10.1111/j.1530-0277.1998.tb03695.x  1
1998 Kreek MJ, Koob GF. Drug dependence: stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence. 51: 23-47. PMID 9716928 DOI: 10.1016/S0376-8716(98)00064-7  1
1998 Schulteis G, Yackey M, Risbrough V, Koob GF. Anxiogenic-like effects of spontaneous and naloxone-precipitated opiate withdrawal in the elevated plus-maze. Pharmacology, Biochemistry, and Behavior. 60: 727-31. PMID 9678657 DOI: 10.1016/S0091-3057(98)00034-3  1
1998 Lee RS, Koob GF, Henriksen SJ. Electrophysiological responses of nucleus accumbens neurons to novelty stimuli and exploratory behavior in the awake, unrestrained rat. Brain Research. 799: 317-22. PMID 9675326 DOI: 10.1016/S0006-8993(98)00477-6  1
1998 Smith GW, Aubry JM, Dellu F, Contarino A, Bilezikjian LM, Gold LH, Chen R, Marchuk Y, Hauser C, Bentley CA, Sawchenko PE, Koob GF, Vale W, Lee KF. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron. 20: 1093-102. PMID 9655498 DOI: 10.1016/S0896-6273(00)80491-2  1
1998 Epping-Jordan MP, Watkins SS, Koob GF, Markou A. Dramatic decreases in brain reward function during nicotine withdrawal. Nature. 393: 76-9. PMID 9590692 DOI: 10.1038/30001  1
1998 Koob GF, Rocio M, Carrera A, Gold LH, Heyser CJ, Maldonado-Irizarry C, Markou A, Parsons LH, Roberts AJ, Schulteis G, Stinus L, Walker JR, Weissenborn R, Weiss F. Substance dependence as a compulsive behavior. Journal of Psychopharmacology (Oxford, England). 12: 39-48. PMID 9584967 DOI: 10.1177/026988119801200106  1
1998 Britton KT, Koob GF. Premenstrual steroids? Nature. 392: 869-870. PMID 9582066 DOI: 10.1038/31816  1
1998 Epping-Jordan MP, Markou A, Koob GF. The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat. Brain Research. 784: 105-15. PMID 9518570 DOI: 10.1016/S0006-8993(97)01190-6  1
1998 Markou A, Kosten TR, Koob GF. Neurobiological similarities in depression and drug dependence: a self-medication hypothesis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 18: 135-74. PMID 9471114 DOI: 10.1016/S0893-133X(97)00113-9  1
1998 Heyser CJ, Schulteis G, Durbin P, Koob GF. Chronic acamprosate eliminates the alcohol deprivation effect while having limited effects on baseline responding for ethanol in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 18: 125-33. PMID 9430136 DOI: 10.1016/S0893-133X(97)00130-9  1
1998 Koob GF. Drug abuse and alcoholism. Overview Advances in Pharmacology (San Diego, Calif.). 42: 969-977. PMID 9328060 DOI: 10.1016/S1054-3589(08)60909-6  1
1997 Walker JR, Koob GF. Orphan anxiety Proceedings of the National Academy of Sciences of the United States of America. 94: 14217-14219. PMID 9405592 DOI: 10.1073/pnas.94.26.14217  1
1997 Koob GF, Le Moal M. Drug abuse: hedonic homeostatic dysregulation. Science (New York, N.Y.). 278: 52-8. PMID 9311926 DOI: 10.1126/science.278.5335.52  1
1997 Ahmed SH, Koob GF. Cocaine- but not food-seeking behavior is reinstated by stress after extinction. Psychopharmacology. 132: 289-95. PMID 9292629 DOI: 10.1007/s002130050347  1
1997 Brot MD, Rall GF, Oldstone MB, Koob GF, Gold LH. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice. Journal of Neurovirology. 3: 265-73. PMID 9291234 DOI: 10.3109/13550289709029467  1
1997 Koob GF, Nestler EJ. The neurobiology of drug addiction Journal of Neuropsychiatry and Clinical Neurosciences. 9: 482-497. PMID 9276849 DOI: 10.1176/JNP.9.3.482  1
1997 Heyser CJ, McDonald JS, Beauchamp V, Koob GF, Gold LH. The effects of cocaine on operant responding for food in several strains of mice. Psychopharmacology. 132: 202-8. PMID 9266618 DOI: 10.1007/s002130050337  1
1997 Caine SB, Koob GF, Parsons LH, Everitt BJ, Schwartz JC, Sokoloff P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats. Neuroreport. 8: 2373-7. PMID 9243643 DOI: 10.1097/00001756-199707070-00054  1
1997 Koob GF, Caine SB, Parsons L, Markou A, Weiss F. Opponent process model and psychostimulant addiction. Pharmacology, Biochemistry, and Behavior. 57: 513-21. PMID 9218276 DOI: 10.1016/S0091-3057(96)00438-8  1
1997 Rodríguez de Fonseca F, Carrera MR, Navarro M, Koob GF, Weiss F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science (New York, N.Y.). 276: 2050-4. PMID 9197270 DOI: 10.1126/science.276.5321.2050  1
1997 Brot MD, Akwa Y, Purdy RH, Koob GF, Britton KT. The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABA(A) receptors. European Journal of Pharmacology. 325: 1-7. PMID 9151931 DOI: 10.1016/S0014-2999(97)00096-4  1
1997 Schulteis G, Heyser CJ, Koob GF. Opiate withdrawal signs precipitated by naloxone following a single exposure to morphine: potentiation with a second morphine exposure. Psychopharmacology. 129: 56-65. PMID 9122364 DOI: 10.1007/s002130050162  1
1997 Raber J, Koob GF, Bloom FE. Interferon-alpha and transforming growth factor-beta 1 regulate corticotropin-releasing factor release from the amygdala: comparison with the hypothalamic response. Neurochemistry International. 30: 455-63. PMID 9106261 DOI: 10.1016/S0197-0186(96)00082-4  1
1997 Koob GF. Circuits, Drugs, and Drug Addiction Advances in Pharmacology. 42: 978-982. DOI: 10.1016/S1054-3589(08)60910-2  1
1996 Pulvirenti L, Balducci C, Koob GF. Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat Neuropharmacology. 35: 1811-1814. PMID 9076761 DOI: 10.1016/S0028-3908(96)00152-9  1
1996 Parsons LH, Weiss F, Koob GF. Serotonin1b receptor stimulation enhances dopamine-mediated reinforcement. Psychopharmacology. 128: 150-60. PMID 8956376 DOI: 10.1007/s002130050120  1
1996 Schulteis G, Koob GF. Reinforcement processes in opiate addiction: a homeostatic model. Neurochemical Research. 21: 1437-54. PMID 8947934 DOI: 10.1007/BF02532385  1
1996 Prospéro-García O, Gold LH, Fox HS, Polis I, Koob GF, Bloom FE, Henriksen SJ. Microglia-passaged simian immunodeficiency virus induces neurophysiological abnormalities in monkeys. Proceedings of the National Academy of Sciences of the United States of America. 93: 14158-63. PMID 8943077 DOI: 10.1073/pnas.93.24.14158  1
1996 Roberts AJ, Cole M, Koob GF. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats Alcoholism: Clinical and Experimental Research. 20: 1289-1298. PMID 8904984 DOI: 10.1111/j.1530-0277.1996.tb01125.x  1
1996 Solbrig MV, Koob GF, Fallon JH, Reid S, Lipkin WI. Prefrontal cortex dysfunction in Borna disease virus (BDV)--infected rats. Biological Psychiatry. 40: 629-36. PMID 8886296 DOI: 10.1016/0006-3223(95)00480-7  1
1996 Weissenborn R, Deroche V, Koob GF, Weiss F. Effects of dopamine agonists and antagonists on cocaine-induced operant responding for a cocaine-associated stimulus. Psychopharmacology. 126: 311-22. PMID 8878347 DOI: 10.1007/BF02247382  1
1996 Vankova ME, Weinger MB, Chen DY, Bronson JB, Motis V, Koob GF. Role of central mu, delta-1, and kappa-1 opioid receptors in opioid-induced muscle rigidity in the rat. Anesthesiology. 85: 574-83. PMID 8853088 DOI: 10.1097/00000542-199609000-00017  1
1996 Hyytiä P, Schulteis G, Koob GF. Intravenous heroin and ethanol self-administration by alcohol-preferring AA and alcohol-avoiding ANA rats. Psychopharmacology. 125: 248-54. PMID 8815960 DOI: 10.1007/BF02247335  1
1996 Macey DJ, Schulteis G, Heinrichs SC, Koob GF. Time-dependent quantifiable withdrawal from ethanol in the rat: effect of method of dependence induction. Alcohol (Fayetteville, N.Y.). 13: 163-70. PMID 8814651 DOI: 10.1016/0741-8329(95)02030-6  1
1996 Solbrig MV, Koob GF, Joyce JN, Lipkin WI. A neural substrate of hyperactivity in Borna disease: Changes in brain dopamine receptors Virology. 222: 332-338. PMID 8806517 DOI: 10.1006/viro.1996.0430  1
1996 Parsons LH, Caine SB, Sokoloff P, Schwartz JC, Koob GF, Weiss F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement. Journal of Neurochemistry. 67: 1078-89. PMID 8752115 DOI: 10.1046/j.1471-4159.1996.67031078.x  1
1996 Matthews K, Baldo BA, Markou A, Lown O, Overstreet DH, Koob GF. Rewarding electrical brain stimulation: similar thresholds for Flinders Sensitive Line Hypercholinergic and Flinders Resistant Line Hypocholinergic rats. Physiology & Behavior. 59: 1155-62. PMID 8737906 DOI: 10.1016/0031-9384(95)02212-0  1
1996 Korte SM, Korte-Bouws GA, Koob GF, De Kloet ER, Bohus B. Mineralocorticoid and glucocorticoid receptor antagonists in animal models of anxiety. Pharmacology, Biochemistry, and Behavior. 54: 261-7. PMID 8728567 DOI: 10.1016/0091-3057(95)02172-8  1
1996 Spina M, Merlo-Pich E, Chan RK, Basso AM, Rivier J, Vale W, Koob GF. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science (New York, N.Y.). 273: 1561-4. PMID 8703220 DOI: 10.1126/science.273.5281.1561  1
1996 de la Torre JC, Mallory M, Brot M, Gold L, Koob G, Oldstone MB, Masliah E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells. Virology. 220: 508-15. PMID 8661403 DOI: 10.1006/viro.1996.0340  1
1996 Schulteis G, Hyytiä P, Heinrichs SC, Koob GF. Effects of chronic ethanol exposure on oral self-administration of ethanol or saccharin by Wistar rats. Alcoholism, Clinical and Experimental Research. 20: 164-71. PMID 8651448 DOI: 10.1111/j.1530-0277.1996.tb01060.x  1
1996 Koob GF. Drug addiction: The Yin and Yang of hedonic homeostasis Neuron. 16: 893-896. PMID 8630244 DOI: 10.1016/S0896-6273(00)80109-9  1
1996 Glassman AH, Koob GF. Psychoactive smoke Nature. 379: 677-678. PMID 8602211 DOI: 10.1038/379677a0  1
1995 Caine SB, Heinrichs SC, Coffin VL, Koob GF. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala or striatum on cocaine self-administration in the rat. Brain Research. 692: 47-56. PMID 8548319 DOI: 10.1016/0006-8993(95)00598-K  1
1995 Rodríguez De Fonseca F, Rubio P, Martín-Calderón JL, Caine SB, Koob GF, Navarro M. The dopamine receptor agonist 7-OH-DPAT modulates the acquisition and expression of morphine-induced place preference. European Journal of Pharmacology. 274: 47-55. PMID 7768280 DOI: 10.1016/0014-2999(94)00708-F  0.8
1995 Withers NW, Pulvirenti L, Koob GF, Gillin JC. Cocaine abuse and dependence. Journal of Clinical Psychopharmacology. 15: 63-78. PMID 7714230 DOI: 10.1097/00004714-199502000-00010  1
1995 Brot MD, Koob GF, Britton KT. Anxiolytic effects of steroid hormones during the estrous cycle. Interactions with ethanol. Recent Developments in Alcoholism : An Official Publication of the American Medical Society On Alcoholism, the Research Society On Alcoholism, and the National Council On Alcoholism. 12: 243-59. PMID 7624546 DOI: 10.1007/0-306-47138-8_16  1
1995 Richter RM, Pich EM, Koob GF, Weiss F. Sensitization of cocaine-stimulated increase in extracellular levels of corticotropin-releasing factor from the rat amygdala after repeated administration as determined by intracranial microdialysis. Neuroscience Letters. 187: 169-72. PMID 7624019 DOI: 10.1016/0304-3940(95)11365-4  1
1995 Schulteis G, Markou A, Cole M, Koob GF. Decreased brain reward produced by ethanol withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 92: 5880-4. PMID 7597046 DOI: 10.1073/pnas.92.13.5880  1
1995 Weissenborn R, Yackey M, Koob GF, Weiss F. Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats. Drug and Alcohol Dependence. 38: 237-46. PMID 7555624 DOI: 10.1016/0376-8716(95)01107-A  1
1995 Carrera MR, Ashley JA, Parsons LH, Wirsching P, Koob GF, Janda KD. Suppression of psychoactive effects of cocaine by active immunization. Nature. 378: 727-30. PMID 7501020 DOI: 10.1038/378727a0  1
1995 Hyytiä P, Koob GF. GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats European Journal of Pharmacology. 283: 151-159. PMID 7498304 DOI: 10.1016/0014-2999(95)00314-B  1
1994 Solbrig MV, Koob GF, Fallon JH, Lipkin WI. Tardive dyskinetic syndrome in rats infected with Borna disease virus. Neurobiology of Disease. 1: 111-9. PMID 9173990 DOI: 10.1006/nbdi.1994.0014  1
1994 Koob GF, Caine B, Markou A, Pulvirenti L, Weiss F. Role for the mesocortical dopamine system in the motivating effects of cocaine. Nida Research Monograph. 145: 1-18. PMID 8742805  1
1994 Cole BJ, Koob GF. Corticotropin-releasing factor and schedule-induced polydipsia. Pharmacology, Biochemistry, and Behavior. 47: 393-8. PMID 8208756 DOI: 10.1016/0091-3057(94)90134-1  1
1994 Stenzel-Poore MP, Heinrichs SC, Rivest S, Koob GF, Vale WW. Overproduction of corticotropin-releasing factor in transgenic mice: a genetic model of anxiogenic behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 2579-84. PMID 8182429  1
1994 Caine SB, Koob GF. Effects of mesolimbic dopamine depletion on responding maintained by cocaine and food Journal of the Experimental Analysis of Behavior. 61: 213-221. PMID 8169570 DOI: 10.1901/JEAB.1994.61-213  1
1994 Raber J, Pich EM, Koob GF, Bloom FE. IL-1 beta potentiates the acetylcholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala. Neuroendocrinology. 59: 208-17. PMID 8159270 DOI: 10.1159/000126661  1
1994 Korte SM, Korte-Bouws GA, Bohus B, Koob GF. Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats. Physiology & Behavior. 56: 115-20. PMID 8084889 DOI: 10.1016/0031-9384(94)90268-2  1
1994 Schulteis G, Koob G. Neuropharmacology. Dark side of drug dependence. Nature. 371: 108-9. PMID 8072539 DOI: 10.1038/371108a0  1
1994 Gillin JC, Pulvirenti L, Withers N, Golshan S, Koob G. The effects of lisuride on mood and sleep during acute withdrawal in stimulant abusers: a preliminary report. Biological Psychiatry. 35: 843-9. PMID 8054406 DOI: 10.1016/0006-3223(94)90019-1  1
1994 Pulvirenti L, Koob GF. Lisuride reduces intravenous cocaine self-administration in rats Pharmacology, Biochemistry and Behavior. 47: 819-822. PMID 8029249 DOI: 10.1016/0091-3057(94)90281-X  1
1994 Menzaghi F, Heinrichs SC, Merlo-Pich E, Tilders FJ, Koob GF. Involvement of hypothalamic corticotropin-releasing factor neurons in behavioral responses to novelty in rats. Neuroscience Letters. 168: 139-42. PMID 8028766 DOI: 10.1016/0304-3940(94)90435-9  1
1994 Gold LH, Stinus L, Inturrisi CE, Koob GF. Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat. European Journal of Pharmacology. 253: 45-51. PMID 8013548 DOI: 10.1016/0014-2999(94)90755-2  1
1994 Gold LH, Brot MD, Polis I, Schroeder R, Tishon A, de la Torre JC, Oldstone MB, Koob GF. Behavioral effects of persistent lymphocytic choriomeningitis virus infection in mice. Behavioral and Neural Biology. 62: 100-9. PMID 7993301 DOI: 10.1016/S0163-1047(05)80031-7  1
1994 Koob GF, Rassnick S, Heinrichs S, Weiss F. Alcohol, the reward system and dependence. Exs. 71: 103-14. PMID 7913351 DOI: 10.1007/978-3-0348-7330-7_11  1
1994 Markou A, Matthews K, Overstreet DH, Koob GF, Geyer MA. Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds. Biological Psychiatry. 36: 680-8. PMID 7880937 DOI: 10.1016/0006-3223(94)91177-0  1
1994 Heinrichs SC, Menzaghi F, Pich EM, Baldwin HA, Rassnick S, Britton KT, Koob GF. Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 11: 179-86. PMID 7865099 DOI: 10.1038/sj.npp.1380104  1
1994 Pulvirenti L, Koob GF. Dopamine receptor agonists, partial agonists and psychostimulant addiction Trends in Pharmacological Sciences. 15: 374-379. PMID 7809953 DOI: 10.1016/0165-6147(94)90158-9  1
1994 Heilig M, Koob GF, Ekman R, Britton KT. Corticotropin-releasing factor and neuropeptide Y: role in emotional integration. Trends in Neurosciences. 17: 80-5. PMID 7512773 DOI: 10.1016/0166-2236(94)90079-5  1
1993 Heinrichs SC, Menzaghi F, Pich EM, Hauger RL, Koob GF. Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide Y. Brain Research. 611: 18-24. PMID 8518948 DOI: 10.1016/0006-8993(93)91771-J  1
1993 Hammer RP, Pires WS, Markou A, Koob GF. Withdrawal following cocaine self-administration decreases regional cerebral metabolic rate in critical brain reward regions. Synapse (New York, N.Y.). 14: 73-80. PMID 8511720 DOI: 10.1002/syn.890140110  1
1993 Pulvirenti L, Koob GF. Lisuride reduces psychomotor retardation during withdrawal from chronic intravenous amphetamine self-administration in rats Neuropsychopharmacology. 8: 213-218. PMID 8507348 DOI: 10.1038/npp.1993.23  1
1993 Amalric M, Berhow M, Polis I, Koob GF. Selective effects of low-dose D2 dopamine receptor antagonism in a reaction-time task in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 8: 195-200. PMID 8507347 DOI: 10.1038/npp.1993.21  0.72
1993 Koob GF, Heinrichs SC, Pich EM, Menzaghi F, Baldwin H, Miczek K, Britton KT. The role of corticotropin-releasing factor in behavioural responses to stress. Ciba Foundation Symposium. 172: 277-89; discussion 2. PMID 8491090 DOI: 10.1002/9780470514368.CH14  1
1993 Cador M, Cole BJ, Koob GF, Stinus L, Le Moal M. Central administration of corticotropin releasing factor induces long-term sensitization to D-amphetamine. Brain Research. 606: 181-6. PMID 8490714 DOI: 10.1016/0006-8993(93)90982-S  1
1993 Rassnick S, Heinrichs SC, Britton KT, Koob GF. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Research. 605: 25-32. PMID 8467387 DOI: 10.1016/0006-8993(93)91352-S  1
1993 Maldonado R, Koob GF. Destruction of the locus coeruleus decreases physical signs of opiate withdrawal Brain Research. 605: 128-138. PMID 8467382 DOI: 10.1016/0006-8993(93)91364-X  1
1993 Baldwin HA, Koob GF. Rapid induction of conditioned opiate withdrawal in the rat Neuropsychopharmacology. 8: 15-21. PMID 8424845 DOI: 10.1038/npp.1993.3  1
1993 Pich EM, Koob GF, Heilig M, Menzaghi F, Vale W, Weiss F. Corticotropin-releasing factor release from the mediobasal hypothalamus of the rat as measured by microdialysis. Neuroscience. 55: 695-707. PMID 8413932 DOI: 10.1016/0306-4522(93)90435-I  1
1993 Menzaghi F, Heinrichs SC, Pich EM, Tilders FJ, Koob GF. Functional impairment of hypothalamic corticotropin-releasing factor neurons with immunotargeted toxins enhances food intake induced by neuropeptide Y. Brain Research. 618: 76-82. PMID 8402180 DOI: 10.1016/0006-8993(93)90431-L  1
1993 Robledo P, Koob GF. Two discrete nucleus accumbens projection areas differentially mediate cocaine self-administration in the rat Behavioural Brain Research. 55: 159-166. PMID 8395179 DOI: 10.1016/0166-4328(93)90112-4  1
1993 Swerdlow NR, Koob GF, Cador M, Lorang M, Hauger RL. Pituitary-adrenal axis responses to acute amphetamine in the rat. Pharmacology, Biochemistry, and Behavior. 45: 629-37. PMID 8392732 DOI: 10.1016/0091-3057(93)90518-X  1
1993 Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science (New York, N.Y.). 259: 528-31. PMID 8380941 DOI: 10.1126/SCIENCE.8380941  1
1993 Pich EM, Heinrichs SC, Rivier C, Miczek KA, Fisher DA, Koob GF. Blockade of pituitary-adrenal axis activation induced by peripheral immunoneutralization of corticotropin-releasing factor does not affect the behavioral response to social defeat stress in rats. Psychoneuroendocrinology. 18: 495-507. PMID 8265737 DOI: 10.1016/0306-4530(93)90043-K  1
1993 Amalric M, Koob GF. Functionally selective neurochemical afferents and efferents of the mesocorticolimbic and nigrostriatal dopamine system. Progress in Brain Research. 99: 209-26. PMID 8108549 DOI: 10.1016/S0079-6123(08)61348-5  1
1993 Heilig M, McLeod S, Brot M, Heinrichs SC, Menzaghi F, Koob GF, Britton KT. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 8: 357-63. PMID 8099792 DOI: 10.1038/npp.1993.35  1
1993 Caine SB, Koob GF. Modulation of cocaine self-administration in the rat through D-3 dopamine receptors Science. 260: 1814-1816. PMID 8099761 DOI: 10.1126/SCIENCE.8099761  1
1993 Markou A, Weiss F, Gold LH, Caine SB, Schulteis G, Koob GF. Animal models of drug craving. Psychopharmacology. 112: 163-82. PMID 7871016 DOI: 10.1007/BF02244907  1
1993 Koob GF, Markou A, Weiss F, Schulteis G. Opponent process and drug dependence: Neurobiological mechanisms Seminars in Neuroscience. 5: 351-358. DOI: 10.1016/S1044-5765(05)80043-0  1
1992 Markou A, Koob GF. Construct validity of a self-stimulation threshold paradigm: effects of reward and performance manipulations. Physiology & Behavior. 51: 111-9. PMID 1741436 DOI: 10.1016/0031-9384(92)90211-J  1
1992 Weiss F, Hurd YL, Ungerstedt U, Markou A, Plotsky PM, Koob GF. Neurochemical correlates of cocaine and ethanol self-administration. Annals of the New York Academy of Sciences. 654: 220-41. PMID 1632585 DOI: 10.1111/j.1749-6632.1992.tb25970.x  1
1992 Koob GF. Neural mechanisms of drug reinforcement Annals of the New York Academy of Sciences. 654: 171-191. PMID 1632582 DOI: 10.1111/j.1749-6632.1992.tb25966.x  1
1992 Koob GF. Drugs of abuse: anatomy, pharmacology and function of reward pathways Trends in Pharmacological Sciences. 13: 177-184. PMID 1604710 DOI: 10.1016/0165-6147(92)90060-J  1
1992 Cador M, Ahmed SH, Koob GF, Le Moal M, Stinus L. Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role. Brain Research. 597: 304-9. PMID 1473001 DOI: 10.1016/0006-8993(92)91487-Y  1
1992 Weiss F, Markou A, Lorang MT, Koob GF. Basal extracellular dopamine levels in the nucleus accumbens are decreased during cocaine withdrawal after unlimited-access self-administration. Brain Research. 593: 314-8. PMID 1450939 DOI: 10.1016/0006-8993(92)91327-B  1
1992 Rassnick S, Pulvirenti L, Koob GF. Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens Psychopharmacology. 109: 92-98. PMID 1365677 DOI: 10.1007/BF02245485  1
1992 Heinrichs SC, Koob GF. Corticotropin-releasing factor modulates dietary preference in nutritionally and physically stressed rats. Psychopharmacology. 109: 177-84. PMID 1365653 DOI: 10.1007/BF02245497  1
1992 Markou A, Hauger RL, Koob GF. Desmethylimipramine attenuates cocaine withdrawal in rats. Psychopharmacology. 109: 305-14. PMID 1365631 DOI: 10.1007/BF02245878  1
1992 Rassnick S, D'Amico E, Riley E, Pulvirenti L, Zieglgansberger W, Koob GF. GABA and nucleus accumbens glutamate neurotransmission modulate ethanol self-administration in rats Annals of the New York Academy of Sciences. 654: 502-505. PMID 1352956 DOI: 10.1111/j.1749-6632.1992.tb26013.x  1
1992 Cador M, Dumas S, Cole BJ, Mallet J, Koob GF, Le Moal M, Stinus L. Behavioral sensitization induced by psychostimulants or stress: search for a molecular basis and evidence for a CRF-dependent phenomenon. Annals of the New York Academy of Sciences. 654: 416-20. PMID 1352953 DOI: 10.1111/j.1749-6632.1992.tb25985.x  1
1992 Koob GF, Weiss F. Neuropharmacology of cocaine and ethanol dependence. Recent Developments in Alcoholism : An Official Publication of the American Medical Society On Alcoholism, the Research Society On Alcoholism, and the National Council On Alcoholism. 10: 201-33. PMID 1350359 DOI: 10.1007/978-1-4899-1648-8_11  1
1992 Heinrichs SC, Pich EM, Miczek KA, Britton KT, Koob GF. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action. Brain Research. 581: 190-7. PMID 1327398 DOI: 10.1016/0006-8993(92)90708-H  1
1992 Koob GF. Dopamine, addiction and reward Seminars in Neuroscience. 4: 139-148. DOI: 10.1016/1044-5765(92)90012-Q  1
1991 Weinger MB, Smith NT, Blasco TA, Koob GF. Brain sites mediating opiate-induced muscle rigidity in the rat: methylnaloxonium mapping study. Brain Research. 544: 181-90. PMID 2039935 DOI: 10.1016/0006-8993(91)90052-W  1
1991 Schroeder RL, Weinger MB, Vakassian L, Koob GF. Methylnaloxonium diffuses out of the rat brain more slowly than naloxone after direct intracerebral injection. Neuroscience Letters. 121: 173-7. PMID 2020373 DOI: 10.1016/0304-3940(91)90678-M  1
1991 Baldwin HA, Wall TL, Schuckit MA, Koob GF. Differential effects of ethanol on punished responding in the P and NP rats. Alcoholism, Clinical and Experimental Research. 15: 700-4. PMID 1928646 DOI: 10.1111/J.1530-0277.1991.TB00582.X  1
1991 Koob GF, Swerdlow NR, Vaccarino F, Hubner C, Pulvirenti L, Weiss F. Functional output of the basal forebrain. Advances in Experimental Medicine and Biology. 295: 291-305. PMID 1776573 DOI: 10.1007/978-1-4757-0145-6_15  1
1991 Pulvirenti L, Swerdlow NR, Koob GF. Nucleus accumbens NMDA antagonist decreases locomotor activity produced by cocaine, heroin or accumbens dopamine, but not caffeine. Pharmacology, Biochemistry, and Behavior. 40: 841-5. PMID 1687766 DOI: 10.1016/0091-3057(91)90095-J  1
1991 Heinrichs SC, Britton KT, Koob GF. Both conditioned taste preference and aversion induced by corticotropin-releasing factor. Pharmacology, Biochemistry, and Behavior. 40: 717-21. PMID 1667823 DOI: 10.1016/0091-3057(91)90075-D  1
1990 Weiss F, Mitchiner M, Bloom FE, Koob GF. Free-choice responding for ethanol versus water in alcohol preferring (P) and unselected Wistar rats is differentially modified by naloxone, bromocriptine, and methysergide. Psychopharmacology. 101: 178-86. PMID 2349359 DOI: 10.1007/BF02244123  1
1990 Hubner CB, Koob GF. The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat Brain Research. 508: 20-29. PMID 2337788 DOI: 10.1016/0006-8993(90)91112-T  1
1990 Weinger MB, Koob GF. What constitutes adequate anesthesia in animals? In neonates? Anesthesiology. 72: 767-9. PMID 2321793 DOI: 10.1097/00000542-199004000-00033  1
1990 Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL. Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology. 100: 413-6. PMID 2315438 DOI: 10.1007/BF02244616  1
1990 Hurd YL, Weiss F, Koob G, Ungerstedt U. The influence of cocaine self-administration on in vivo dopamine and acetylcholine neurotransmission in rat caudate-putamen. Neuroscience Letters. 109: 227-33. PMID 2314639 DOI: 10.1016/0304-3940(90)90568-T  1
1990 Melia KF, Koob GF, Ehlers CL. Ethanol effects on delayed spatial matching as modeled by a negative exponential forgetting function. Psychopharmacology. 102: 391-8. PMID 2251335 DOI: 10.1007/BF02244109  1
1990 Cole BJ, Cador M, Stinus L, Rivier C, Rivier J, Vale W, Le Moal M, Koob GF. Critical role of the hypothalamic pituitary adrenal axis in amphetamine-induced sensitization of behavior. Life Sciences. 47: 1715-20. PMID 2250584 DOI: 10.1016/0024-3205(90)90344-Q  1
1990 Stinus L, Le Moal M, Koob GF. Nucleus accumbens and amygdala are possible substrates for the aversive stimulus effects of opiate withdrawal. Neuroscience. 37: 767-73. PMID 2247222 DOI: 10.1016/0306-4522(90)90106-E  1
1990 Weinger MB, Schreiber JF, Koob GF. Effects of two benzodiazepine inverse agonists, RO 15-4513 and FG 7142, on recovery from pentobarbital and halothane anesthesia in the rat Pharmacology, Biochemistry and Behavior. 35: 889-895. PMID 2111915 DOI: 10.1016/0091-3057(90)90376-S  1
1990 Koob GF, Weiss F. Pharmacology of drug self-administration. Alcohol (Fayetteville, N.Y.). 7: 193-7. PMID 1970479 DOI: 10.1016/0741-8329(90)90004-V  1
1990 Swerdlow NR, Koob GF. Toward a unified hypothesis of cortico-striato-pallido-thalamus function? Behavioral and Brain Sciences. 13: 172-177. DOI: 10.1017/S0140525X00078195  1
1989 Britton KT, Koob GF. Effects of corticotropin releasing factor, desipramine and haloperidol on a DRL schedule of reinforcement Pharmacology, Biochemistry and Behavior. 32: 967-970. PMID 2798545 DOI: 10.1016/0091-3057(89)90067-1  1
1989 Hurd YL, Weiss F, Koob GF, And NE, Ungerstedt U. Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study. Brain Research. 498: 199-203. PMID 2790475 DOI: 10.1016/0006-8993(89)90422-8  1
1989 Pulvirenti L, Swerdlow NR, Koob GF. Microinjection of a glutamate antagonist into the nucleus accumbens reduces psychostimulant locomotion in rats. Neuroscience Letters. 103: 213-8. PMID 2771183 DOI: 10.1016/0304-3940(89)90578-8  1
1989 Amalric M, Koob GF. Dorsal pallidum as a functional motor output of the corpus striatum. Brain Research. 483: 389-94. PMID 2706530 DOI: 10.1016/0006-8993(89)90186-8  1
1989 Koob GF, Lebrun C, Bluthé RM, Dantzer R, Le Moal M. Role of neuropeptides in learning versus performance: focus on vasopressin. Brain Research Bulletin. 23: 359-64. PMID 2686806 DOI: 10.1016/0361-9230(89)90222-0  1
1989 Koob GF, Stinus L, Le Moal M, Bloom FE. Opponent process theory of motivation: neurobiological evidence from studies of opiate dependence. Neuroscience and Biobehavioral Reviews. 13: 135-40. PMID 2682399 DOI: 10.1016/S0149-7634(89)80022-3  1
1989 Swerdlow NR, Britton KT, Koob GF. Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by alpha-helical CRF (9-41). Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 2: 285-92. PMID 2610824 DOI: 10.1016/0893-133X(89)90033-X  1
1989 Weiss F, Ettenberg A, Koob GF. CCK-8 injected into the nucleus accumbens attenuates the supersensitive locomotor response to apomorphine in 6-OHDA and chronic-neuroleptic treated rats. Psychopharmacology. 99: 409-15. PMID 2574480 DOI: 10.1007/BF00445568  1
1989 Gold LH, Koob GF. MDMA produces stimulant-like conditioned locomotor activity. Psychopharmacology. 99: 352-6. PMID 2574478 DOI: 10.1007/BF00445556  1
1989 Gold LH, Hubner CB, Koob GF. A role for the mesolimbic dopamine system in the psychostimulant actions of MDMA. Psychopharmacology. 99: 40-7. PMID 2571175 DOI: 10.1007/BF00634450  1
1989 Unterwald EM, Tempel A, Koob GF, Zukin RS. Characterization of opioid receptors in rat nucleus accumbens following mesolimbic dopaminergic lesions. Brain Research. 505: 111-8. PMID 2558779 DOI: 10.1016/0006-8993(89)90120-0  1
1989 Swerdlow NR, Koob GF. Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine. Pharmacology, Biochemistry, and Behavior. 33: 595-9. PMID 2511575 DOI: 10.1016/0091-3057(89)90394-8  1
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