George F. Koob - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Neurobiology of emotion
Website:
https://www.scripps.edu/research/faculty/koob

264 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? Alcohol and Alcoholism (Oxford, Oxfordshire). 54: 497-502. PMID 31535696 DOI: 10.1093/alcalc/agz054  0.92
2019 Zorrilla EP, Koob GF. Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 188. PMID 31501652 DOI: 10.3389/fnbeh.2019.00188  1
2019 Zorrilla EP, Koob GF. Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 136. PMID 31293401 DOI: 10.3389/fnbeh.2019.00136  1
2019 Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. Plos Biology. 17: e2006421. PMID 30990816 DOI: 10.1371/journal.pbio.2006421  0.92
2019 Carmack SA, Keeley RJ, Vendruscolo JC, Lowery-Gionta EG, Lu H, Koob GF, Stein EA, Vendruscolo LF. Heroin addiction engages negative emotional learning brain circuits in rats. The Journal of Clinical Investigation. 130. PMID 30913040 DOI: 10.1172/JCI125534  0.92
2019 de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nature Communications. 10: 1238. PMID 30886240 DOI: 10.1038/s41467-019-09183-0  1
2019 Towers EB, Tunstall BJ, McCracken MM, Vendruscolo LF, Koob GF. Male and female mice develop escalation of heroin intake and dependence following extended access. Neuropharmacology. PMID 30880124 DOI: 10.1016/j.neuropharm.2019.03.019  0.92
2019 Tyler RE, Kim SW, Guo M, Joo Jang Y, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND. Detecting neuroinflammation in brain following chronic alcohol exposure in rats: a comparison between in vivo and in vitro TSPO radioligand binding. The European Journal of Neuroscience. PMID 30803059 DOI: 10.1111/ejn.14392  0.92
2019 Kwako LE, Schwandt ML, Ramchandani VA, Diazgranados N, Koob GF, Volkow ND, Blanco C, Goldman D. Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder. The American Journal of Psychiatry. appiajp201818030357. PMID 30606047 DOI: 10.1176/appi.ajp.2018.18030357  0.36
2018 Frantz K, Roberto M, Mason B, Koob GF, Volkow N, Rodriguez de Fonseca F. Larry Parsons: Researcher, mentor, and friend. Addiction Biology. 23: 1204-1206. PMID 30485629 DOI: 10.1111/adb.12686  0.64
2018 Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L. Ghrelin receptor deletion reduces binge-like alcohol drinking in rats. Journal of Neuroendocrinology. e12663. PMID 30456835 DOI: 10.1111/jne.12663  0.92
2018 Somkuwar SS, Quach LW, Quigley JA, Purohit DC, Fannon MJ, Koob GF, Mandyam CD. Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. Brain Sciences. 8. PMID 29949891 DOI: 10.3390/brainsci8070119  0.96
2018 Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Molecular Psychiatry. PMID 29880881 DOI: 10.1038/s41380-018-0080-y  1
2018 Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, ... ... Koob GF, et al. Influence of alcoholism and cholesterol on TSPO binding in brain: PET [C]PBR28 studies in humans and rodents. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29777199 DOI: 10.1038/s41386-018-0085-x  0.92
2018 Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C. Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29703996 DOI: 10.1038/s41386-018-0054-4  0.92
2018 Kenny PJ, Hoyer D, Koob GF. Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou. Biological Psychiatry. PMID 29602521 DOI: 10.1016/j.biopsych.2018.02.009  0.88
2018 Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing aPromoter Polymorphism. Frontiers in Psychiatry. 9: 28. PMID 29497387 DOI: 10.3389/fpsyt.2018.00028  1
2018 Tian YH, Ma SX, Lee KW, Wee S, Koob GF, Lee SY, Jang CG. Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects. Scientific Reports. 8: 882. PMID 29343767 DOI: 10.1038/s41598-018-19207-2  0.84
2017 Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biological Psychiatry. PMID 29357981 DOI: 10.1016/j.biopsych.2017.10.031  1
2017 George O, Koob GF. Individual differences in the neuropsychopathology of addiction. Dialogues in Clinical Neuroscience. 19: 217-229. PMID 29302219  1
2017 Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats. Neuropharmacology. 131: 96-103. PMID 29217282 DOI: 10.1016/j.neuropharm.2017.12.006  0.92
2017 Francesconi W, Szücs A, Berton F, Koob GF, Vendruscolo LF, Sanna PP. Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST). Psychopharmacology. PMID 28986608 DOI: 10.1007/s00213-017-4732-4  0.92
2017 Moore CF, Sabino V, Koob GF, Cottone P. Neuroscience of Compulsive Eating Behavior. Frontiers in Neuroscience. 11: 469. PMID 28883784 DOI: 10.3389/fnins.2017.00469  1
2017 Vendruscolo JC, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater S, Taffe M, Koob GF, Vendruscolo LF. Compulsive-Like Sufentanil Vapor Self-Administration in the Rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28812595 DOI: 10.1038/npp.2017.172  1
2017 Kwako LE, Koob GF. Neuroclinical Framework for the Role of Stress in Addiction. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 28653044  0.36
2017 Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF. Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking. Current Opinion in Behavioral Sciences. 13: 85-90. PMID 28603755 DOI: 10.1016/j.cobeha.2016.10.006  0.92
2016 Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt J, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, ... ... Koob GF, et al. Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27986929 DOI: 10.1523/JNEUROSCI.2002-16.2016  1
2016 Moore CF, Sabino V, Koob GF, Cottone P. Pathological Overeating: Emerging Evidence for a Compulsivity Construct. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27922596 DOI: 10.1038/npp.2016.269  1
2016 Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27917870 DOI: 10.1038/npp.2016.270  1
2016 Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. Reply to: Neuroclinical Assessment of Addiction Needs to Incorporate Decision-Making Measures and Ecological Validity. Biological Psychiatry. PMID 27776735 DOI: 10.1016/j.biopsych.2016.08.029  0.36
2016 de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9446-53. PMID 27605618 DOI: 10.1523/JNEUROSCI.1395-16.2016  1
2016 Schmeichel BE, Herman MA, Roberto M, Koob GF. Hypocretin Neurotransmission Within the Central Amygdala Mediates Escalated Cocaine Self-Administration and Stress-Induced Reinstatement in Rats. Biological Psychiatry. PMID 27567312 DOI: 10.1016/j.biopsych.2016.06.010  0.64
2016 Priddy BM, Carmack SA, Thomas LC, Vendruscolo JC, Koob GF, Vendruscolo LF. Sex, strain, and estrous cycle influences on alcohol drinking in rats. Pharmacology, Biochemistry, and Behavior. PMID 27498303 DOI: 10.1016/j.pbb.2016.08.001  0.92
2016 Verheij MM, Vendruscolo LF, Caffino L, Giannotti G, Cazorla M, Fumagalli F, Riva MA, Homberg JR, Koob GF, Contet C. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8149-59. PMID 27488635 DOI: 10.1523/JNEUROSCI.2711-14.2016  1
2016 Koob GF. The Dark Side of Addiction: The Horsley Gantt to Joseph Brady Connection. The Journal of Nervous and Mental Disease. PMID 27356121 DOI: 10.1097/NMD.0000000000000551  1
2016 Becker JB, Koob GF. Sex Differences in Animal Models: Focus on Addiction. Pharmacological Reviews. 68: 242-63. PMID 26772794 DOI: 10.1124/pr.115.011163  1
2016 Chavkin C, Koob GF. Dynorphin, Dysphoria, and Dependence: the Stress of Addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 373-4. PMID 26657953 DOI: 10.1038/npp.2015.258  1
2015 Kwako LE, Momenan R, Litten RZ, Koob GF, Goldman D. Addictions Neuroclinical Assessment: A Neuroscience-Based Framework for Addictive Disorders. Biological Psychiatry. PMID 26772405 DOI: 10.1016/j.biopsych.2015.10.024  0.36
2015 Koob GF, Mason BJ. Existing and Future Drugs for the Treatment of the Dark Side of Addiction. Annual Review of Pharmacology and Toxicology. PMID 26514207 DOI: 10.1146/annurev-pharmtox-010715-103143  1
2015 You IJ, Wright SR, Garcia-Garcia AL, Tapper AR, Gardner PD, Koob GF, Leonardo ED, Bohn LM, Wee S. 5-HT1A Autoreceptors in the Dorsal Raphe Nucleus Convey Vulnerability to Compulsive Cocaine Seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26324408 DOI: 10.1038/npp.2015.268  1
2015 Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. The Journal of Clinical Investigation. PMID 26121746 DOI: 10.1172/JCI79828  1
2015 Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, et al. Brain pathways to recovery from alcohol dependence. Alcohol (Fayetteville, N.Y.). 49: 435-52. PMID 26074423 DOI: 10.1016/j.alcohol.2015.04.006  1
2015 Repunte-Canonigo V, Shin W, Vendruscolo LF, Lefebvre C, van der Stap L, Kawamura T, Schlosburg JE, Alvarez M, Koob GF, Califano A, Sanna PP. Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks. Genome Biology. 16: 68. PMID 25886852 DOI: 10.1186/s13059-015-0593-5  1
2015 Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6241-53. PMID 25878294 DOI: 10.1523/JNEUROSCI.3302-14.2015  1
2015 Litten RZ, Ryan ML, Falk DE, Reilly M, Fertig JB, Koob GF. Heterogeneity of alcohol use disorder: understanding mechanisms to advance personalized treatment. Alcoholism, Clinical and Experimental Research. 39: 579-84. PMID 25833016 DOI: 10.1111/acer.12669  1
2015 Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4296-305. PMID 25762676 DOI: 10.1523/JNEUROSCI.1978-13.2015  1
2015 Koob GF, Griebel G. Pharmacology, biochemistry and behavior: the 2015 transition. Pharmacology, Biochemistry, and Behavior. 131: iii. PMID 25661528 DOI: 10.1016/j.pbb.2015.02.001  1
2015 Koob GF. The dark side of emotion: the addiction perspective. European Journal of Pharmacology. 753: 73-87. PMID 25583178 DOI: 10.1016/j.ejphar.2014.11.044  1
2015 Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1123-9. PMID 25367502 DOI: 10.1038/npp.2014.293  1
2015 Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF. Compulsive-like responding for opioid analgesics in rats with extended access. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 421-8. PMID 25060491 DOI: 10.1038/npp.2014.188  1
2015 Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology. 232: 453-63. PMID 25059540 DOI: 10.1007/s00213-014-3685-0  1
2015 Park PE, Schlosburg JE, Vendruscolo LF, Schulteis G, Edwards S, Koob GF. Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia. Addiction Biology. 20: 275-84. PMID 24330252 DOI: 10.1111/adb.12120  1
2015 Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology. 20: 56-68. PMID 23869743 DOI: 10.1111/adb.12077  1
2014 Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, ... ... Koob GF, et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17: 1751-8. PMID 25402857 DOI: 10.1038/nn.3872  1
2014 Koob GF. Neurocircuitry of alcohol addiction: synthesis from animal models. Handbook of Clinical Neurology. 125: 33-54. PMID 25307567 DOI: 10.1016/B978-0-444-62619-6.00003-3  1
2014 Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Molecular Neurodegeneration. 9: 26. PMID 24980976 DOI: 10.1186/1750-1326-9-26  1
2014 George O, Koob GF, Vendruscolo LF. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology. 231: 3911-7. PMID 24923982 DOI: 10.1007/s00213-014-3623-1  1
2014 Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behavioural Brain Research. 271: 171-6. PMID 24914463 DOI: 10.1016/j.bbr.2014.06.003  1
2014 Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. Plos One. 9: e97216. PMID 24816773 DOI: 10.1371/journal.pone.0097216  1
2014 Mazei-Robison MS, Appasani R, Edwards S, Wee S, Taylor SR, Picciotto MR, Koob GF, Nestler EJ. Self-administration of ethanol, cocaine, or nicotine does not decrease the soma size of ventral tegmental area dopamine neurons. Plos One. 9: e95962. PMID 24755634 DOI: 10.1371/journal.pone.0095962  1
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd ML, Crystal RG. Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine. Human Gene Therapy. Clinical Development. 25: 40-9. PMID 24649839 DOI: 10.1089/humc.2013.231  1
2014 Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1722-31. PMID 24549104 DOI: 10.1038/npp.2014.20  1
2014 Hicks MJ, Kaminsky SM, De BP, Rosenberg JB, Evans SM, Foltin RW, Andrenyak DM, Moody DE, Koob GF, Janda KD, Ricart Arbona RJ, Lepherd M, Crystal RG. Fate of Systemically Administered Cocaine in Nonhuman Primates Treated with the dAd5GNE Anti-cocaine Vaccine. Human Gene Therapy. Clinical Development. PMID 24548017 DOI: 10.1089/hum.2013.231  0.92
2014 Zorrilla EP, Logrip ML, Koob GF. Corticotropin releasing factor: a key role in the neurobiology of addiction. Frontiers in Neuroendocrinology. 35: 234-44. PMID 24456850 DOI: 10.1016/j.yfrne.2014.01.001  1
2014 Buck CL, Vendruscolo LF, Koob GF, George O. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology. 231: 929-37. PMID 24221826 DOI: 10.1007/s00213-013-3307-2  1
2014 Gilpin NW, Roberto M, Koob GF, Schweitzer P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala. Neuropharmacology. 77: 294-302. PMID 24157490 DOI: 10.1016/j.neuropharm.2013.10.005  1
2014 Wise RA, Koob GF. The development and maintenance of drug addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 254-62. PMID 24121188 DOI: 10.1038/npp.2013.261  1
2014 Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. Addiction as a stress surfeit disorder. Neuropharmacology. 76: 370-82. PMID 23747571 DOI: 10.1016/j.neuropharm.2013.05.024  1
2014 Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addiction Biology. 19: 755-7. PMID 23639035 DOI: 10.1111/adb.12059  1
2014 Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. Hippocampal neurogenesis protects against cocaine-primed relapse. Addiction Biology. 19: 562-74. PMID 23278919 DOI: 10.1111/adb.12019  1
2013 Kreifeldt M, Le D, Treistman SN, Koob GF, Contet C. BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice. Frontiers in Integrative Neuroscience. 7: 105. PMID 24416005 DOI: 10.3389/fnint.2013.00105  1
2013 Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19384-92. PMID 24305833 DOI: 10.1523/JNEUROSCI.1979-13.2013  1
2013 Zorrilla EP, Roberts AJ, Rivier JE, Koob GF. Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. Plos One. 8: e63942. PMID 24015170 DOI: 10.1371/journal.pone.0063942  1
2013 Cai X, Whitfield T, Moreno AY, Grant Y, Hixon MS, Koob GF, Janda KD. Probing the effects of hapten stability on cocaine vaccine immunogenicity. Molecular Pharmaceutics. 10: 4176-84. PMID 23927436 DOI: 10.1021/mp400214w  1
2013 Koob GF. Addiction is a Reward Deficit and Stress Surfeit Disorder. Frontiers in Psychiatry. 4: 72. PMID 23914176 DOI: 10.3389/fpsyt.2013.00072  1
2013 Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behavioural Pharmacology. 24: 356-62. PMID 23839030 DOI: 10.1097/FBP.0b013e3283644d15  1
2013 Kallupi M, Wee S, Edwards S, Whitfield TW, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biological Psychiatry. 74: 520-8. PMID 23751206 DOI: 10.1016/j.biopsych.2013.04.028  1
2013 Chen J, Repunte-Canonigo V, Kawamura T, Lefebvre C, Shin W, Howell LL, Hemby SE, Harvey BK, Califano A, Morales M, Koob GF, Sanna PP. Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor. Nature Communications. 4: 1955. PMID 23736082 DOI: 10.1038/ncomms2955  1
2013 Maoz A, Hicks MJ, Vallabhjosula S, Synan M, Kothari PJ, Dyke JP, Ballon DJ, Kaminsky SM, De BP, Rosenberg JB, Martinez D, Koob GF, Janda KD, Crystal RG. Adenovirus capsid-based anti-cocaine vaccine prevents cocaine from binding to the nonhuman primate CNS dopamine transporter. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2170-8. PMID 23660705 DOI: 10.1038/npp.2013.114  1
2013 Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AA, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9036-41. PMID 23650354 DOI: 10.1073/pnas.1219159110  1
2013 Koob GF. Negative reinforcement in drug addiction: the darkness within. Current Opinion in Neurobiology. 23: 559-63. PMID 23628232 DOI: 10.1016/j.conb.2013.03.011  1
2013 Cai X, Whitfield T, Hixon MS, Grant Y, Koob GF, Janda KD. Probing active cocaine vaccination performance through catalytic and noncatalytic hapten design. Journal of Medicinal Chemistry. 56: 3701-9. PMID 23627877 DOI: 10.1021/jm400228w  1
2013 Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF. Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 1867-75. PMID 23590881 DOI: 10.1017/S1461145713000308  1
2013 George O, Koob GF. Control of craving by the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 110: 4165-6. PMID 23483010 DOI: 10.1073/pnas.1301245110  1
2013 Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 976-84. PMID 23303056 DOI: 10.1038/npp.2012.261  1
2013 Zorrilla EP, Koob GF. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley. Neuroscience and Biobehavioral Reviews. 37: 1932-45. PMID 23220696 DOI: 10.1016/j.neubiorev.2012.11.019  1
2013 Herman MA, Kallupi M, Luu G, Oleata CS, Heilig M, Koob GF, Ciccocioppo R, Roberto M. Enhanced GABAergic transmission in the central nucleus of the amygdala of genetically selected Marchigian Sardinian rats: alcohol and CRF effects. Neuropharmacology. 67: 337-48. PMID 23220399 DOI: 10.1016/j.neuropharm.2012.11.026  1
2013 De BP, Pagovich OE, Hicks MJ, Rosenberg JB, Moreno AY, Janda KD, Koob GF, Worgall S, Kaminsky SM, Sondhi D, Crystal RG. Disrupted adenovirus-based vaccines against small addictive molecules circumvent anti-adenovirus immunity. Human Gene Therapy. 24: 58-66. PMID 23140508 DOI: 10.1089/hum.2012.163  1
2013 Jang CG, Whitfield T, Schulteis G, Koob GF, Wee S. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology. 225: 753-63. PMID 23007601 DOI: 10.1007/s00213-012-2864-0  1
2013 Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Current Topics in Behavioral Neurosciences. 13: 3-30. PMID 21744309 DOI: 10.1007/7854_2011_129  1
2012 Higley AE, Koob GF, Mason BJ. Treatment of alcohol dependence with drug antagonists of the stress response. Alcohol Research : Current Reviews. 34: 516-21. PMID 23584117  1
2012 George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences of the United States of America. 109: 18156-61. PMID 23071333 DOI: 10.1073/pnas.1116523109  1
2012 Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neuroscience and Biobehavioral Reviews. 36: 2179-92. PMID 22975446 DOI: 10.1016/j.neubiorev.2012.07.010  1
2012 Moreno AY, Azar MR, Koob GF, Janda KD. Probing the protective effects of a conformationally constrained nicotine vaccine. Vaccine. 30: 6665-70. PMID 22963803 DOI: 10.1016/j.vaccine.2012.08.064  1
2012 Wee S, Vendruscolo LF, Misra KK, Schlosburg JE, Koob GF. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. Science Translational Medicine. 4: 146ra110. PMID 22875830 DOI: 10.1126/scitranslmed.3003948  1
2012 Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7563-71. PMID 22649234 DOI: 10.1523/JNEUROSCI.0069-12.2012  1
2012 Koob GF. Animal models of psychiatric disorders. Handbook of Clinical Neurology. 106: 137-66. PMID 22608620 DOI: 10.1016/B978-0-444-52002-9.00009-7  1
2012 Cohen A, Koob GF, George O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2153-60. PMID 22549121 DOI: 10.1038/npp.2012.67  1
2012 Rosenberg JB, Hicks MJ, De BP, Pagovich O, Frenk E, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Tignor N, Mezey JG, Crystal RG. AAVrh.10-mediated expression of an anti-cocaine antibody mediates persistent passive immunization that suppresses cocaine-induced behavior. Human Gene Therapy. 23: 451-9. PMID 22486244 DOI: 10.1089/hum.2011.178  1
2012 Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology. 223: 17-25. PMID 22418732 DOI: 10.1007/s00213-012-2682-4  1
2012 Mandyam CD, Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends in Neurosciences. 35: 250-60. PMID 22265158 DOI: 10.1016/j.tins.2011.12.005  1
2012 Edwards S, Koob GF. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. Methods in Molecular Biology (Clifton, N.J.). 829: 31-48. PMID 22231805 DOI: 10.1007/978-1-61779-458-2_2  1
2012 Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1275-87. PMID 22205547 DOI: 10.1038/npp.2011.315  1
2012 Koob GF, Zorrilla EP. Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 308-9. PMID 22157874 DOI: 10.1038/npp.2011.213  1
2012 Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism. Neuropharmacology. 62: 1142-51. PMID 22119954 DOI: 10.1016/j.neuropharm.2011.11.006  1
2012 George O, Le Moal M, Koob GF. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiology & Behavior. 106: 58-64. PMID 22108506 DOI: 10.1016/j.physbeh.2011.11.004  1
2012 Lenoir M, Guillem K, Koob GF, Ahmed SH. Drug specificity in extended access cocaine and heroin self-administration. Addiction Biology. 17: 964-76. PMID 21995515 DOI: 10.1111/j.1369-1600.2011.00385.x  1
2012 Wee S, Hicks MJ, De BP, Rosenberg JB, Moreno AY, Kaminsky SM, Janda KD, Crystal RG, Koob GF. Novel cocaine vaccine linked to a disrupted adenovirus gene transfer vector blocks cocaine psychostimulant and reinforcing effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1083-91. PMID 21918504 DOI: 10.1038/npp.2011.200  1
2012 Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology. 62: 552-64. PMID 21782834 DOI: 10.1016/j.neuropharm.2011.07.007  1
2012 Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Addiction Biology. 17: 300-8. PMID 21762287 DOI: 10.1111/j.1369-1600.2011.00329.x  1
2012 Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addiction Biology. 17: 76-85. PMID 21309953 DOI: 10.1111/j.1369-1600.2010.00291.x  1
2012 Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addiction Biology. 17: 108-20. PMID 21309947 DOI: 10.1111/j.1369-1600.2010.00284.x  1
2011 Stowe GN, Schlosburg JE, Vendruscolo LF, Edwards S, Misra KK, Schulteis G, Zakhari JS, Koob GF, Janda KD. Developing a vaccine against multiple psychoactive targets: a case study of heroin. Cns & Neurological Disorders Drug Targets. 10: 865-75. PMID 22229311  1
2011 Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. Journal of Medicinal Chemistry. 54: 5195-204. PMID 21692508 DOI: 10.1021/jm200461m  1
2011 Mihindou C, Vouillac C, Koob GF, Ahmed SH. Preclinical validation of a novel cocaine exposure therapy for relapse prevention. Biological Psychiatry. 70: 593-8. PMID 21571256 DOI: 10.1016/j.biopsych.2011.03.036  1
2011 Parylak SL, Koob GF, Zorrilla EP. The dark side of food addiction. Physiology & Behavior. 104: 149-56. PMID 21557958 DOI: 10.1016/j.physbeh.2011.04.063  1
2011 Gilpin NW, Misra K, Herman MA, Cruz MT, Koob GF, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biological Psychiatry. 69: 1091-9. PMID 21459365 DOI: 10.1016/j.biopsych.2011.02.004  1
2011 George O, Koob GF. Craving, context and the cortex. Nature Neuroscience. 14: 409-10. PMID 21445066 DOI: 10.1038/nn.2787  1
2011 Logrip ML, Koob GF, Zorrilla EP. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. Cns Drugs. 25: 271-87. PMID 21425881 DOI: 10.2165/11587790-000000000-00000  1
2011 Vendruscolo LF, Schlosburg JE, Misra KK, Chen SA, Greenwell TN, Koob GF. Escalation patterns of varying periods of heroin access. Pharmacology, Biochemistry, and Behavior. 98: 570-4. PMID 21406200 DOI: 10.1016/j.pbb.2011.03.004  1
2011 Contet C, Gardon O, Filliol D, Becker JA, Koob GF, Kieffer BL. Identification of genes regulated in the mouse extended amygdala by excessive ethanol drinking associated with dependence. Addiction Biology. 16: 615-9. PMID 21392173 DOI: 10.1111/j.1369-1600.2010.00304.x  1
2011 Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1207-18. PMID 21346735 DOI: 10.1038/npp.2011.5  1
2011 Allen CD, Lee S, Koob GF, Rivier C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain, Behavior, and Immunity. 25: S50-60. PMID 21300146 DOI: 10.1016/j.bbi.2011.01.016  1
2011 Crabbe JC, Harris RA, Koob GF. Preclinical studies of alcohol binge drinking. Annals of the New York Academy of Sciences. 1216: 24-40. PMID 21272009 DOI: 10.1111/j.1749-6632.2010.05895.x  1
2011 Hicks MJ, De BP, Rosenberg JB, Davidson JT, Moreno AY, Janda KD, Wee S, Koob GF, Hackett NR, Kaminsky SM, Worgall S, Toth M, Mezey JG, Crystal RG. Cocaine analog coupled to disrupted adenovirus: a vaccine strategy to evoke high-titer immunity against addictive drugs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 612-9. PMID 21206484 DOI: 10.1038/mt.2010.280  1
2011 George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology. 213: 715-22. PMID 20924754 DOI: 10.1007/s00213-010-2024-3  1
2011 Walker BM, Zorrilla EP, Koob GF. Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addiction Biology. 16: 116-9. PMID 20579007 DOI: 10.1111/j.1369-1600.2010.00226.x  1
2010 Koob GF. Focus on: Neuroscience and treatment: the potential of neuroscience to inform treatment. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 33: 144-51. PMID 23579944  1
2010 Gilpin NW, Koob GF. Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology. 212: 431-9. PMID 20676608 DOI: 10.1007/s00213-010-1967-8  1
2010 Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurology. 5: 393-401. PMID 20563312 DOI: 10.2217/fnl.10.14  1
2010 Shurman J, Koob GF, Gutstein HB. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Medicine (Malden, Mass.). 11: 1092-8. PMID 20545871 DOI: 10.1111/j.1526-4637.2010.00881.x  1
2010 George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 35: 232-47. PMID 20493211 DOI: 10.1016/j.neubiorev.2010.05.002  1
2010 Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. The dopamine D3 receptor partial agonist CJB090 and antagonist PG01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addiction Biology. 15: 312-23. PMID 20456290 DOI: 10.1111/j.1369-1600.2010.00211.x  1
2010 George O, Grieder TE, Cole M, Koob GF. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacology, Biochemistry, and Behavior. 96: 104-7. PMID 20420848 DOI: 10.1016/j.pbb.2010.04.013  1
2010 Wee S, Koob GF. The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse. Psychopharmacology. 210: 121-35. PMID 20352414 DOI: 10.1007/s00213-010-1825-8  1
2010 Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discovery Today. 15: 371-83. PMID 20206287 DOI: 10.1016/j.drudis.2010.02.011  1
2010 Moreno AY, Azar MR, Warren NA, Dickerson TJ, Koob GF, Janda KD. A critical evaluation of a nicotine vaccine within a self-administration behavioral model. Molecular Pharmaceutics. 7: 431-41. PMID 20104903 DOI: 10.1021/mp900213u  1
2010 Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biological Psychiatry. 67: 831-9. PMID 20060104 DOI: 10.1016/j.biopsych.2009.11.007  1
2010 Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Current Opinion in Investigational Drugs (London, England : 2000). 11: 63-71. PMID 20047160  1
2010 Koob GF. The role of CRF and CRF-related peptides in the dark side of addiction. Brain Research. 1314: 3-14. PMID 19912996 DOI: 10.1016/j.brainres.2009.11.008  1
2010 Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 217-38. PMID 19710631 DOI: 10.1038/npp.2009.110  1
2009 Koob GF, Simon EJ. The Neurobiology of Addiction: Where We Have Been and Where We Are Going. Journal of Drug Issues. 39: 115-132. PMID 20622969  1
2009 Roberto M, Koob GF. First Congress of "Alcoholism and stress: a framework for future treatment strategies": Introduction to the proceeding. Alcohol (Fayetteville, N.Y.). 43: 489-90. PMID 19913191 DOI: 10.1016/j.alcohol.2009.10.008  1
2009 Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proceedings of the National Academy of Sciences of the United States of America. 106: 20016-20. PMID 19901333 DOI: 10.1073/pnas.0908789106  1
2009 Gilpin NW, Smith AD, Cole M, Weiss F, Koob GF, Richardson HN. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcoholism, Clinical and Experimental Research. 33: 2113-23. PMID 19740131 DOI: 10.1111/j.1530-0277.2009.01051.x  1
2009 Francesconi W, Berton F, Koob GF, Sanna PP. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Progress in Neuro-Psychopharmacology & Biological Psychiatry. 33: 1347-55. PMID 19683025 DOI: 10.1016/j.pnpbp.2009.08.003  1
2009 Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam CD. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiology of Disease. 36: 1-10. PMID 19501165 DOI: 10.1016/j.nbd.2009.05.021  1
2009 Wee S, Orio L, Ghirmai S, Cashman JR, Koob GF. Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine. Psychopharmacology. 205: 565-75. PMID 19484223 DOI: 10.1007/s00213-009-1563-y  1
2009 Koob GF, Kenneth Lloyd G, Mason BJ. Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nature Reviews. Drug Discovery. 8: 500-15. PMID 19483710 DOI: 10.1038/nrd2828  1
2009 Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology. 205: 327-35. PMID 19440699 DOI: 10.1007/s00213-009-1548-x  1
2009 Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5389-401. PMID 19403807 DOI: 10.1523/JNEUROSCI.5129-08.2009  1
2009 Orio L, Edwards S, George O, Parsons LH, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4846-57. PMID 19369553 DOI: 10.1523/JNEUROSCI.0563-09.2009  1
2009 Koob GF. Brain stress systems in the amygdala and addiction. Brain Research. 1293: 61-75. PMID 19332030 DOI: 10.1016/j.brainres.2009.03.038  1
2009 Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addiction Biology. 14: 130-43. PMID 19291009 DOI: 10.1111/j.1369-1600.2008.00142.x  1
2009 Koob GF. New dimensions in human laboratory models of addiction. Addiction Biology. 14: 1-8. PMID 19133879 DOI: 10.1111/j.1369-1600.2008.00127.x  1
2009 Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1482-93. PMID 18946467 DOI: 10.1038/npp.2008.192  1
2009 Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology. 56: 18-31. PMID 18725236 DOI: 10.1016/j.neuropharm.2008.07.043  1
2009 Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacology, Biochemistry, and Behavior. 91: 295-302. PMID 18703080 DOI: 10.1016/j.pbb.2008.07.012  1
2008 Koob GF. Hedonic Homeostatic Dysregulation as a Driver of Drug-Seeking Behavior. Drug Discovery Today. Disease Models. 5: 207-215. PMID 20054425 DOI: 10.1016/j.ddmod.2009.04.002  1
2008 Gilpin NW, Koob GF. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 31: 185-95. PMID 19881886  1
2008 Richardson HN, Lee SY, O'Dell LE, Koob GF, Rivier CL. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. The European Journal of Neuroscience. 28: 1641-53. PMID 18979677 DOI: 10.1111/j.1460-9568.2008.06455.x  1
2008 Koob GF, Le Moal M. Review. Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 363: 3113-23. PMID 18653439 DOI: 10.1098/rstb.2008.0094  1
2008 Gilpin NW, Richardson HN, Cole M, Koob GF. Vapor inhalation of alcohol in rats. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 9.29. PMID 18634001 DOI: 10.1002/0471142301.ns0929s44  1
2008 Gilpin NW, Richardson HN, Koob GF. Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcoholism, Clinical and Experimental Research. 32: 1535-42. PMID 18631323 DOI: 10.1111/j.1530-0277.2008.00745.x  1
2008 Koob GF. A role for brain stress systems in addiction. Neuron. 59: 11-34. PMID 18614026 DOI: 10.1016/j.neuron.2008.06.012  1
2008 Walker BM, Koob GF. Regarding "Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake". Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2113; author reply 2. PMID 18593720 DOI: 10.1096/fj.08-0702LTR  1
2008 Koob GF. Corticotropin-releasing factor, neuroplasticity (sensitization), and alcoholism. Proceedings of the National Academy of Sciences of the United States of America. 105: 8809-10. PMID 18583480 DOI: 10.1073/pnas.0804354105  1
2008 Roberto M, Gilpin NW, O'Dell LE, Cruz MT, Morse AC, Siggins GR, Koob GF. Cellular and behavioral interactions of gabapentin with alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5762-71. PMID 18509038 DOI: 10.1523/JNEUROSCI.0575-08.2008  1
2008 Gilpin NW, Misra K, Koob GF. Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacology, Biochemistry, and Behavior. 90: 475-80. PMID 18501411 DOI: 10.1016/j.pbb.2008.04.006  1
2008 Mandyam CD, Wee S, Crawford EF, Eisch AJ, Richardson HN, Koob GF. Varied access to intravenous methamphetamine self-administration differentially alters adult hippocampal neurogenesis. Biological Psychiatry. 64: 958-65. PMID 18490002 DOI: 10.1016/j.biopsych.2008.04.010  1
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, ... ... Koob GF, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/j.biopsych.2008.03.005  1
2008 Walker BM, Rasmussen DD, Raskind MA, Koob GF. alpha1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol (Fayetteville, N.Y.). 42: 91-7. PMID 18358987 DOI: 10.1016/j.alcohol.2007.12.002  1
2008 Papaleo F, Ghozland S, Ingallinesi M, Roberts AJ, Koob GF, Contarino A. Disruption of the CRF(2) receptor pathway decreases the somatic expression of opiate withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2878-87. PMID 18288089 DOI: 10.1038/npp.2008.8  1
2008 Ji D, Gilpin NW, Richardson HN, Rivier CL, Koob GF. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behavioural Pharmacology. 19: 1-12. PMID 18195589 DOI: 10.1097/FBP.0b013e3282f3cf70  1
2008 Koob GF. Alcoholism, corticotropin-releasing factor, and molecular genetic allostasis. Biological Psychiatry. 63: 137-8. PMID 18164903 DOI: 10.1016/j.biopsych.2007.10.005  1
2008 Koob GF, Le Moal M. Addiction and the brain antireward system. Annual Review of Psychology. 59: 29-53. PMID 18154498 DOI: 10.1146/annurev.psych.59.103006.093548  1
2008 George O, Mandyam CD, Wee S, Koob GF. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2474-82. PMID 18033234 DOI: 10.1038/sj.npp.1301626  1
2008 Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology, Biochemistry, and Behavior. 88: 497-510. PMID 18031798 DOI: 10.1016/j.pbb.2007.10.008  1
2008 Specio SE, Wee S, O'Dell LE, Boutrel B, Zorrilla EP, Koob GF. CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology. 196: 473-82. PMID 17965976 DOI: 10.1007/s00213-007-0983-9  1
2008 Wee S, Mandyam CD, Lekic DM, Koob GF. Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 18: 303-11. PMID 17920248 DOI: 10.1016/j.euroneuro.2007.08.003  1
2008 Guillem K, Vouillac C, Koob GF, Cador M, Stinus L. Monoamine oxidase inhibition dramatically prolongs the duration of nicotine withdrawal-induced place aversion. Biological Psychiatry. 63: 158-63. PMID 17643399 DOI: 10.1016/j.biopsych.2007.04.029  1
2008 Walker BM, Koob GF. Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 643-52. PMID 17473837 DOI: 10.1038/sj.npp.1301438  1
2007 Koob GF, Miller SC, Wunsch MJ. Inaugural issue of the journal of addiction medicine. Journal of Addiction Medicine. 1: 1. PMID 21768924 DOI: 10.1097/ADM.0b013e318033d5bf  1
2007 Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13140-50. PMID 18045908 DOI: 10.1523/JNEUROSCI.2284-07.2007  1
2007 Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF. Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11442-50. PMID 17942739 DOI: 10.1523/JNEUROSCI.2505-07.2007  1
2007 George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences of the United States of America. 104: 17198-203. PMID 17921249 DOI: 10.1073/pnas.0707585104  1
2007 Zhang Z, Morse AC, Koob GF, Schulteis G. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcoholism, Clinical and Experimental Research. 31: 1811-9. PMID 17877783 DOI: 10.1111/j.1530-0277.2007.00483.x  1
2007 Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences. 30: 399-406. PMID 17629579 DOI: 10.1016/j.tins.2007.06.006  1
2007 Treweek J, Wee S, Koob GF, Dickerson TJ, Janda KD. Self-vaccination by methamphetamine glycation products chemically links chronic drug abuse and cardiovascular disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 11580-4. PMID 17592122 DOI: 10.1073/pnas.0701328104  1
2007 Funk CK, Koob GF. A CRF(2) agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Research. 1155: 172-8. PMID 17512918 DOI: 10.1016/j.brainres.2007.04.009  1
2007 Chu K, Koob GF, Cole M, Zorrilla EP, Roberts AJ. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacology, Biochemistry, and Behavior. 86: 813-21. PMID 17482248 DOI: 10.1016/j.pbb.2007.03.009  1
2007 Thorsell A, Repunte-Canonigo V, O'Dell LE, Chen SA, King AR, Lekic D, Koob GF, Sanna PP. Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats. Brain : a Journal of Neurology. 130: 1330-7. PMID 17405766 DOI: 10.1093/brain/awm033  1
2007 Brogan AP, Eubanks LM, Koob GF, Dickerson TJ, Janda KD. Antibody-catalyzed oxidation of delta(9)-tetrahydrocannabinol. Journal of the American Chemical Society. 129: 3698-702. PMID 17335216 DOI: 10.1021/ja070022m  1
2007 Wee S, Wang Z, Woolverton WL, Pulvirenti L, Koob GF. Effect of aripiprazole, a partial dopamine D2 receptor agonist, on increased rate of methamphetamine self-administration in rats with prolonged session duration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2238-47. PMID 17327886 DOI: 10.1038/sj.npp.1301353  1
2007 O'Dell LE, Koob GF. 'Nicotine deprivation effect' in rats with intermittent 23-hour access to intravenous nicotine self-administration. Pharmacology, Biochemistry, and Behavior. 86: 346-53. PMID 17292952 DOI: 10.1016/j.pbb.2007.01.004  1
2007 Walker BM, Koob GF. The gamma-aminobutyric acid-B receptor agonist baclofen attenuates responding for ethanol in ethanol-dependent rats. Alcoholism, Clinical and Experimental Research. 31: 11-8. PMID 17207096 DOI: 10.1111/j.1530-0277.2006.00259.x  1
2007 Wee S, Specio SE, Koob GF. Effects of dose and session duration on cocaine self-administration in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 1134-43. PMID 17202405 DOI: 10.1124/jpet.106.113340  1
2007 Le Moal M, Koob GF. Drug addiction: pathways to the disease and pathophysiological perspectives. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 377-93. PMID 17169534 DOI: 10.1016/j.euroneuro.2006.10.006  1
2007 Solbrig MV, Adrian R, Wechsler SL, Koob GF. Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. European Journal of Pharmacology. 555: 23-9. PMID 17126318 DOI: 10.1016/j.ejphar.2006.10.025  1
2007 O'Dell LE, Chen SA, Smith RT, Specio SE, Balster RL, Paterson NE, Markou A, Zorrilla EP, Koob GF. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 180-93. PMID 17050784 DOI: 10.1124/jpet.106.105270  1
2007 Fekete EM, Inoue K, Zhao Y, Rivier JE, Vale WW, Szücs A, Koob GF, Zorrilla EP. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1052-68. PMID 17019404 DOI: 10.1038/sj.npp.1301214  1
2007 Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biological Psychiatry. 61: 78-86. PMID 16876134 DOI: 10.1016/j.biopsych.2006.03.063  1
2006 Heinrichs SC, Koob GF. Application of experimental stressors in laboratory rodents. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit8.4. PMID 18428648 DOI: 10.1002/0471142301.ns0804s34  1
2006 Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. The European Journal of Neuroscience. 24: 3532-40. PMID 17229101 DOI: 10.1111/j.1460-9568.2006.05217.x  1
2006 O'Brien CP, Koob GF, Mee-Lee D, Rosenthal RN. New developments in addiction treatment. The Journal of Clinical Psychiatry. 67: 1801-12. PMID 17196062  1
2006 Eubanks LM, Rogers CJ, Beuscher AE, Koob GF, Olson AJ, Dickerson TJ, Janda KD. A molecular link between the active component of marijuana and Alzheimer's disease pathology. Molecular Pharmaceutics. 3: 773-7. PMID 17140265 DOI: 10.1021/mp060066m  1
2006 Funk CK, O'Dell LE, Crawford EF, Koob GF. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11324-32. PMID 17079660 DOI: 10.1523/JNEUROSCI.3096-06.2006  1
2006 Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology. 189: 175-86. PMID 17047935 DOI: 10.1007/s00213-006-0546-5  1
2006 Crabbe JC, Phillips TJ, Harris RA, Arends MA, Koob GF. Alcohol-related genes: contributions from studies with genetically engineered mice. Addiction Biology. 11: 195-269. PMID 16961758 DOI: 10.1111/j.1369-1600.2006.00038.x  1
2006 Koob GF. The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction (Abingdon, England). 101: 23-30. PMID 16930158 DOI: 10.1111/j.1360-0443.2006.01586.x  1
2006 Steffensen SC, Stobbs SH, Colago EE, Lee RS, Koob GF, Gallegos RA, Henriksen SJ. Contingent and non-contingent effects of heroin on mu-opioid receptor-containing ventral tegmental area GABA neurons. Experimental Neurology. 202: 139-51. PMID 16814775 DOI: 10.1016/j.expneurol.2006.05.023  1
2006 Kenny PJ, Chen SA, Kitamura O, Markou A, Koob GF. Conditioned withdrawal drives heroin consumption and decreases reward sensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5894-900. PMID 16738231 DOI: 10.1523/JNEUROSCI.0740-06.2006  1
2006 Hoefer ME, Voskanian SJ, Koob GF, Pulvirenti L. Effects of terguride, ropinirole, and acetyl-L-carnitine on methamphetamine withdrawal in the rat. Pharmacology, Biochemistry, and Behavior. 83: 403-9. PMID 16647107 DOI: 10.1016/j.pbb.2006.02.023  0.88
2006 Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF, Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Proceedings of the National Academy of Sciences of the United States of America. 103: 6368-73. PMID 16618939 DOI: 10.1073/pnas.0510188103  1
2006 O'Dell LE, Bruijnzeel AW, Smith RT, Parsons LH, Merves ML, Goldberger BA, Richardson HN, Koob GF, Markou A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction. Psychopharmacology. 186: 612-9. PMID 16598454 DOI: 10.1007/s00213-006-0383-6  1
2006 Kitamura O, Wee S, Specio SE, Koob GF, Pulvirenti L. Escalation of methamphetamine self-administration in rats: a dose-effect function. Psychopharmacology. 186: 48-53. PMID 16552556 DOI: 10.1007/s00213-006-0353-z  0.88
2006 Johnson BA, Koob GF, Schuckit MA, Mason BJ, Ait-Daoud N. Understanding and treating alcohol dependence. Alcoholism, Clinical and Experimental Research. 30: 567-84. PMID 16499499 DOI: 10.1111/j.1530-0277.2005.00066.x  1
2006 Chen SA, O'Dell LE, Hoefer ME, Greenwell TN, Zorrilla EP, Koob GF. Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2692-707. PMID 16452993 DOI: 10.1038/sj.npp.1301008  1
2006 Solbrig MV, Adrian R, Baratta J, Lauterborn JC, Koob GF. Kappa opioid control of seizures produced by a virus in an animal model. Brain : a Journal of Neurology. 129: 642-54. PMID 16399805 DOI: 10.1093/brain/awl008  1
2005 Boutrel B, Kenny PJ, Specio SE, Martin-Fardon R, Markou A, Koob GF, de Lecea L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Proceedings of the National Academy of Sciences of the United States of America. 102: 19168-73. PMID 16357203 DOI: 10.1073/pnas.0507480102  1
2005 Qi L, Yamamoto N, Meijler MM, Altobell LJ, Koob GF, Wirsching P, Janda KD. Delta9-tetrahydrocannabinol immunochemical studies: haptens, monoclonal antibodies, and a convenient synthesis of radiolabeled delta9-tetrahydrocannabinol. Journal of Medicinal Chemistry. 48: 7389-99. PMID 16279798 DOI: 10.1021/jm050442r  1
2005 Koob GF, Le Moal M. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nature Neuroscience. 8: 1442-4. PMID 16251985 DOI: 10.1038/nn1105-1442  1
2005 Guillem K, Vouillac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8593-600. PMID 16177026 DOI: 10.1523/JNEUROSCI.2139-05.2005  1
2005 Sanchis-Segura C, Grisel JE, Olive MF, Ghozland S, Koob GF, Roberts AJ, Cowen MS. Role of the endogenous opioid system on the neuropsychopharmacological effects of ethanol: new insights about an old question. Alcoholism, Clinical and Experimental Research. 29: 1522-7. PMID 16156049 DOI: 10.1097/01.alc.0000174913.60384.e8  1
2005 Ahmed SH, Lutjens R, van der Stap LD, Lekic D, Romano-Spica V, Morales M, Koob GF, Repunte-Canonigo V, Sanna PP. Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction. Proceedings of the National Academy of Sciences of the United States of America. 102: 11533-8. PMID 16076954 DOI: 10.1073/pnas.0504438102  1
2005 Izzo E, Sanna PP, Koob GF. Impairment of dopaminergic system function after chronic treatment with corticotropin-releasing factor. Pharmacology, Biochemistry, and Behavior. 81: 701-8. PMID 16005056 DOI: 10.1016/j.pbb.2005.04.017  0.72
2005 Ahmed SH, Koob GF. Transition to drug addiction: a negative reinforcement model based on an allostatic decrease in reward function. Psychopharmacology. 180: 473-90. PMID 15731896 DOI: 10.1007/s00213-005-2180-z  1
2005 Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF, Lê DA, O'Dell LE, Overstreet DH, Roberts AJ, Sinha R, Valdez GR, Weiss F. Stress enhancement of craving during sobriety: a risk for relapse. Alcoholism, Clinical and Experimental Research. 29: 185-95. PMID 15714042 DOI: 10.1097/01.ALC.0000153544.83656.3C  1
2005 Zorrilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF. Measuring meals: structure of prandial food and water intake of rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1450-67. PMID 15637168 DOI: 10.1152/ajpregu.00175.2004  1
2005 Zorrilla EP, Inoue K, Valdez GR, Tabarin A, Koob GF. Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology. 177: 324-35. PMID 15609069 DOI: 10.1007/s00213-004-1952-1  1
2005 Kenny PJ, Boutrel B, Gasparini F, Koob GF, Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology. 179: 247-54. PMID 15602687 DOI: 10.1007/s00213-004-2069-2  1
2005 Stinus L, Cador M, Zorrilla EP, Koob GF. Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 90-8. PMID 15138444 DOI: 10.1038/sj.npp.1300487  1
2004 Valdez GR, Koob GF. Allostasis and dysregulation of corticotropin-releasing factor and neuropeptide Y systems: implications for the development of alcoholism. Pharmacology, Biochemistry, and Behavior. 79: 671-89. PMID 15582675 DOI: 10.1016/j.pbb.2004.09.020  1
2004 O'Dell LE, Roberts AJ, Smith RT, Koob GF. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcoholism, Clinical and Experimental Research. 28: 1676-82. PMID 15547454 DOI: 10.1097/01.ALC.0000145781.11923.4E  1
2004 Boutrel B, Koob GF. What keeps us awake: the neuropharmacology of stimulants and wakefulness-promoting medications. Sleep. 27: 1181-94. PMID 15532213  1
2004 Navarro M, Carrera MR, Del Arco I, Trigo JM, Koob GF, Rodríguez de Fonseca F. Cannabinoid receptor antagonist reduces heroin self-administration only in dependent rats. European Journal of Pharmacology. 501: 235-7. PMID 15464083 DOI: 10.1016/j.ejphar.2004.08.022  0.44
2004 Koob GF. A role for GABA mechanisms in the motivational effects of alcohol. Biochemical Pharmacology. 68: 1515-25. PMID 15451394 DOI: 10.1016/j.bcp.2004.07.031  1
2004 Koob GF, Greenwell TN. Neuropeptide S: a novel activating anxiolytic? Neuron. 43: 441-2. PMID 15312642 DOI: 10.1016/j.neuron.2004.08.007  1
2004 Heinrichs SC, Koob GF. Corticotropin-releasing factor in brain: a role in activation, arousal, and affect regulation. The Journal of Pharmacology and Experimental Therapeutics. 311: 427-40. PMID 15297468 DOI: 10.1124/jpet.103.052092  1
2004 Martin G, Guadaño-Ferraz A, Morte B, Ahmed S, Koob GF, De Lecea L, Siggins GR. Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of Pharmacology and Experimental Therapeutics. 311: 265-73. PMID 15263066 DOI: 10.1124/jpet.104.067504  1
2004 O'Dell LE, Bruijnzeel AW, Ghozland S, Markou A, Koob GF. Nicotine withdrawal in adolescent and adult rats. Annals of the New York Academy of Sciences. 1021: 167-74. PMID 15251887 DOI: 10.1196/annals.1308.022  1
2004 Carrera MR, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. Treating cocaine addiction with viruses. Proceedings of the National Academy of Sciences of the United States of America. 101: 10416-21. PMID 15226496 DOI: 10.1073/pnas.0403795101  0.92
2004 Zorrilla EP, Koob GF. The therapeutic potential of CRF1 antagonists for anxiety. Expert Opinion On Investigational Drugs. 13: 799-828. PMID 15212620 DOI: 10.1517/13543784.13.7.799  1
2004 Valdez GR, Sabino V, Koob GF. Increased anxiety-like behavior and ethanol self-administration in dependent rats: reversal via corticotropin-releasing factor-2 receptor activation. Alcoholism, Clinical and Experimental Research. 28: 865-72. PMID 15201629  1
2004 Koob GF. Allostatic view of motivation: implications for psychopathology. Nebraska Symposium On Motivation. Nebraska Symposium On Motivation. 50: 1-18. PMID 15160636  1
2004 Inoue K, Zorrilla EP, Tabarin A, Valdez GR, Iwasaki S, Kiriike N, Koob GF. Reduction of anxiety after restricted feeding in the rat: implication for eating disorders. Biological Psychiatry. 55: 1075-81. PMID 15158426 DOI: 10.1016/j.biopsych.2004.01.026  1
2004 Zorrilla EP, Reinhardt LE, Valdez GR, Inoue K, Rivier JE, Vale WW, Koob GF. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. The Journal of Pharmacology and Experimental Therapeutics. 310: 1027-34. PMID 15115804 DOI: 10.1124/jpet.104.068676  1
2004 Koob GF, Ahmed SH, Boutrel B, Chen SA, Kenny PJ, Markou A, O'Dell LE, Parsons LH, Sanna PP. Neurobiological mechanisms in the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 27: 739-49. PMID 15019424 DOI: 10.1016/j.neubiorev.2003.11.007  1
2004 Weed MR, Gold LH, Polis I, Koob GF, Fox HS, Taffe MA. Impaired performance on a rhesus monkey neuropsychological testing battery following simian immunodeficiency virus infection. Aids Research and Human Retroviruses. 20: 77-89. PMID 15000701 DOI: 10.1089/088922204322749521  1
2004 Ahmed SH, Koob GF. Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology. 172: 450-4. PMID 14647962 DOI: 10.1007/s00213-003-1682-9  1
2004 Ben-Shahar O, Ahmed SH, Koob GF, Ettenberg A. The transition from controlled to compulsive drug use is associated with a loss of sensitization. Brain Research. 995: 46-54. PMID 14644470 DOI: 10.1016/j.brainres.2003.09.053  1
2003 Kenny PJ, Koob GF, Markou A. Conditioned facilitation of brain reward function after repeated cocaine administration. Behavioral Neuroscience. 117: 1103-7. PMID 14570559 DOI: 10.1037/0735-7044.117.5.1103  1
2003 Zorrilla EP, Taché Y, Koob GF. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends in Pharmacological Sciences. 24: 421-7. PMID 12915052 DOI: 10.1016/S0165-6147(03)00177-9  1
2003 Walker JR, Chen SA, Moffitt H, Inturrisi CE, Koob GF. Chronic opioid exposure produces increased heroin self-administration in rats. Pharmacology, Biochemistry, and Behavior. 75: 349-54. PMID 12873626 DOI: 10.1016/S0091-3057(03)00094-7  1
2003 Valdez GR, Zorrilla EP, Rivier J, Vale WW, Koob GF. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist. Brain Research. 980: 206-12. PMID 12867260 DOI: 10.1016/S0006-8993(03)02971-8  1
2003 Ahmed SH, Lin D, Koob GF, Parsons LH. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels. Journal of Neurochemistry. 86: 102-13. PMID 12807430 DOI: 10.1046/j.1471-4159.2003.01833.x  1
2003 Koob GF, Roberts AJ, Kieffer BL, Heyser CJ, Katner SN, Ciccocioppo R, Weiss F. Animal models of motivation for drinking in rodents with a focus on opioid receptor neuropharmacology. Recent Developments in Alcoholism : An Official Publication of the American Medical Society On Alcoholism, the Research Society On Alcoholism, and the National Council On Alcoholism. 16: 263-81. PMID 12638642  1
2003 Kenny PJ, Polis I, Koob GF, Markou A. Low dose cocaine self-administration transiently increases but high dose cocaine persistently decreases brain reward function in rats. The European Journal of Neuroscience. 17: 191-5. PMID 12534985 DOI: 10.1046/j.1460-9568.2003.02443.x  1
2002 Izzo E, Martin-Fardon R, Koob GF, Weiss F, Sanna PP. Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. Nature Neuroscience. 5: 1263-4. PMID 12436114 DOI: 10.1038/nn977  1
2002 Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Research. 952: 188-99. PMID 12376179 DOI: 10.1016/S0006-8993(02)03189-X  1
2002 Contarino A, Picetti R, Matthes HW, Koob GF, Kieffer BL, Gold LH. Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. European Journal of Pharmacology. 446: 103-9. PMID 12098591 DOI: 10.1016/S0014-2999(02)01812-5  1
2002 Ahmed SH, Kenny PJ, Koob GF, Markou A. Neurobiological evidence for hedonic allostasis associated with escalating cocaine use. Nature Neuroscience. 5: 625-6. PMID 12055635 DOI: 10.1038/nn872  1
2002 Ryabinin AE, Bachtell RK, Heinrichs SC, Lee S, Rivier C, Olive MF, Mehmert KK, Camarini R, Kim JA, Koenig HN, Nannini MA, Hodge CW, Roberts AJ, Koob GF. The corticotropin-releasing factor/urocortin system and alcohol. Alcoholism, Clinical and Experimental Research. 26: 714-22. PMID 12045481  1
2000 Contarino A, Dellu FO, Koob GF, Smith GW, Lee K, Vale WW, Gold LH. Dissociation of Locomotor Activation and Suppression of Food Intake Induced by CRF in CRFR1-Deficient Mice. Endocrinology. 141: 2698-2702. PMID 28200977 DOI: 10.1210/endo.141.7.7653  0.64
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