Joaquin Espinosa - Publications

Affiliations: 
Molecular, Cellular and Developmental Biology University of Colorado, Boulder, Boulder, CO, United States 
Area:
Human Development, Molecular Biology, Neuroscience Biology

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, et al. Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Molecular Cell. PMID 31495563 DOI: 10.1016/j.molcel.2019.07.034  0.52
2019 Oliphant MUJ, Vincent MY, Galbraith MD, Pandey A, Zaberezhnyy V, Rudra P, Johnson KR, Costello JC, Ghosh D, DeGregori J, Espinosa JM, Ford HL. Six2 mediates late-stage metastasis via direct regulation of Sox2 and induction of a cancer stem cell program. Cancer Research. PMID 30606720 DOI: 10.1158/0008-5472.CAN-18-1791  0.52
2018 Galbraith MD, Bender H, Espinosa JM. Therapeutic targeting of transcriptional cyclin-dependent kinases. Transcription. 1-19. PMID 30409083 DOI: 10.1080/21541264.2018.1539615  0.52
2018 Abraham CG, Ludwig MP, Andrysik Z, Pandey A, Joshi M, Galbraith MD, Sullivan KD, Espinosa JM. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. Cell Reports. 24: 3224-3236. PMID 30232004 DOI: 10.1016/j.celrep.2018.08.058  0.52
2017 Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Mechanisms of transcriptional regulation by p53. Cell Death and Differentiation. PMID 29125602 DOI: 10.1038/cdd.2017.174  0.52
2017 Galbraith MD, Andrysik Z, Pandey A, Hoh M, Bonner EA, Hill AA, Sullivan KD, Espinosa JM. CDK8 Kinase Activity Promotes Glycolysis. Cell Reports. 21: 1495-1506. PMID 29117556 DOI: 10.1016/j.celrep.2017.10.058  0.52
2017 Andrysik Z, Galbraith MD, Guarnieri AL, Zaccara S, Sullivan KD, Pandey A, MacBeth M, Inga A, Espinosa JM. Identification of a core TP53 transcriptional program with highly distributed tumor suppressive activity. Genome Research. PMID 28904012 DOI: 10.1101/gr.220533.117  0.52
2017 Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ. A kinase-independent role for CDK19 in p53 response. Molecular and Cellular Biology. PMID 28416637 DOI: 10.1128/MCB.00626-16  0.52
2016 Andrews FH, Tong Q, Sullivan KD, Cornett EM, Zhang Y, Ali M, Ahn J, Pandey A, Guo AH, Strahl BD, Costello JC, Espinosa JM, Rothbart SB, Kutateladze TG. Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Cell Reports. 16: 3195-207. PMID 27653685 DOI: 10.1016/j.celrep.2016.08.050  0.8
2016 Sullivan KD, Lewis HC, Hill AA, Pandey A, Jackson LP, Cabral JM, Smith KP, Liggett LA, Gomez EB, Galbraith MD, DeGregori J, Espinosa JM. Trisomy 21 consistently activates the interferon response. Elife. 5. PMID 27472900 DOI: 10.7554/eLife.16220  0.52
2016 Perez-Perri JI, Dengler VL, Audetat KA, Pandey A, Bonner EA, Urh M, Mendez J, Daniels DL, Wappner P, Galbraith MD, Espinosa JM. The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Reports. PMID 27320910 DOI: 10.1016/j.celrep.2016.05.082  0.52
2016 Espinosa JM. Revisiting lncRNAs: How Do You Know Yours Is Not an eRNA? Molecular Cell. 62: 1-2. PMID 27058782 DOI: 10.1016/j.molcel.2016.03.022  0.8
2016 Nichol JN, Galbraith MD, Kleinman CL, Espinosa JM, Miller WH. NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia. Cell Reports. 14: 2938-49. PMID 26997274 DOI: 10.1016/j.celrep.2016.02.074  0.8
2015 Towers CG, Guarnieri AL, Micalizzi DS, Harrell JC, Gillen AE, Kim J, Wang CA, Oliphant MU, Drasin DJ, Guney MA, Kabos P, Sartorius CA, Tan AC, Perou CM, Espinosa JM, et al. The Six1 oncoprotein downregulates p53 via concomitant regulation of RPL26 and microRNA-27a-3p. Nature Communications. 6: 10077. PMID 26687066 DOI: 10.1038/ncomms10077  0.8
2015 Espinosa JM, Sullivan KD. A signature for success. Elife. 4. PMID 26079875 DOI: 10.7554/eLife.08773  0.8
2015 Sullivan KD, Nakagawa A, Xue D, Espinosa JM. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle (Georgetown, Tex.). 14: 1771-8. PMID 25853217 DOI: 10.1080/15384101.2015.1026518  0.8
2015 Tentler JJ, Ionkina AA, Tan AC, Newton TP, Pitts TM, Glogowska MJ, Kabos P, Sartorius CA, Sullivan KD, Espinosa JM, Eckhardt SG, Diamond JR. p53 Family Members Regulate Phenotypic Response to Aurora Kinase A Inhibition in Triple-Negative Breast Cancer. Molecular Cancer Therapeutics. 14: 1117-29. PMID 25758253 DOI: 10.1158/1535-7163.MCT-14-0538-T  0.8
2015 Sullivan KD, Palaniappan VV, Espinosa JM. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle (Georgetown, Tex.). 14: 56-63. PMID 25483068 DOI: 10.4161/15384101.2014.973330  0.8
2014 Allen MA, Andrysik Z, Dengler VL, Mellert HS, Guarnieri A, Freeman JA, Sullivan KD, Galbraith MD, Luo X, Kraus WL, Dowell RD, Espinosa JM. Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. Elife. 3: e02200. PMID 24867637 DOI: 10.7554/eLife.02200.001  0.8
2014 Dengler VL, Galbraith MD, Espinosa JM. Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology. 49: 1-15. PMID 24099156 DOI: 10.3109/10409238.2013.838205  0.52
2013 Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. The Journal of Biological Chemistry. 288: 33171-80. PMID 24097987 DOI: 10.1074/jbc.M113.518175  0.8
2013 Galbraith MD, Saxton J, Li L, Shelton SJ, Zhang H, Espinosa JM, Shaw PE. ERK phosphorylation of MED14 in promoter complexes during mitogen-induced gene activation by Elk-1. Nucleic Acids Research. 41: 10241-53. PMID 24049075 DOI: 10.1093/nar/gkt837  0.52
2013 Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 153: 1327-39. PMID 23746844 DOI: 10.1016/j.cell.2013.04.048  0.8
2013 Mellert H, Espinosa JM. Tumor suppression by p53: is apoptosis important or not? Cell Reports. 3: 1335-6. PMID 23726020 DOI: 10.1016/j.celrep.2013.05.011  0.8
2013 Freeman JA, Espinosa JM. The impact of post-transcriptional regulation in the p53 network. Briefings in Functional Genomics. 12: 46-57. PMID 23242178 DOI: 10.1093/bfgp/els058  0.8
2012 Smallwood A, Hon GC, Jin F, Henry RE, Espinosa JM, Ren B. CBX3 regulates efficient RNA processing genome-wide. Genome Research. 22: 1426-36. PMID 22684280 DOI: 10.1101/gr.124818.111  0.8
2012 Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nature Chemical Biology. 8: 646-54. PMID 22660439 DOI: 10.1038/nchembio.965  0.8
2012 Sullivan KD, Gallant-Behm CL, Henry RE, Fraikin JL, Espinosa JM. The p53 circuit board. Biochimica Et Biophysica Acta. 1825: 229-44. PMID 22333261 DOI: 10.1016/j.bbcan.2012.01.004  0.8
2012 Henry RE, Andrysik Z, París R, Galbraith MD, Espinosa JM. A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX. The Embo Journal. 31: 1266-78. PMID 22246181 DOI: 10.1038/emboj.2011.498  0.52
2012 Espinosa JM. Get back TFIIF, don't let me Gdown1. Molecular Cell. 45: 3-5. PMID 22244325 DOI: 10.1016/j.molcel.2011.12.016  0.8
2011 Galbraith MD, Espinosa JM. Lessons on transcriptional control from the serum response network. Current Opinion in Genetics & Development. 21: 160-6. PMID 21316215 DOI: 10.1016/j.gde.2011.01.011  0.52
2010 Galbraith MD, Donner AJ, Espinosa JM. CDK8: a positive regulator of transcription. Transcription. 1: 4-12. PMID 21327159 DOI: 10.4161/trns.1.1.12373  0.8
2010 Espinosa JM. The meaning of pausing. Molecular Cell. 40: 507-8. PMID 21095581 DOI: 10.1016/j.molcel.2010.11.025  0.8
2010 Gomes NP, Espinosa JM. Disparate chromatin landscapes and kinetics of inactivation impact differential regulation of p53 target genes. Cell Cycle (Georgetown, Tex.). 9: 3428-37. PMID 20818159 DOI: 10.4161/cc.9.17.12998  1
2010 Gomes NP, Espinosa JM. Gene-specific repression of the p53 target gene PUMA via intragenic CTCF-Cohesin binding. Genes & Development. 24: 1022-34. PMID 20478995 DOI: 10.1101/gad.1881010  1
2010 Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, ... ... Espinosa JM, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell. 140: 280-93. PMID 20141841 DOI: 10.1016/j.cell.2009.12.041  0.8
2010 Donner AJ, Ebmeier CC, Taatjes DJ, Espinosa JM. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nature Structural & Molecular Biology. 17: 194-201. PMID 20098423 DOI: 10.1038/nsmb.1752  0.8
2010 Gomes NP, Espinosa JM. Differential regulation of p53 target genes: it's (core promoter) elementary. Genes & Development. 24: 111-4. PMID 20080948 DOI: 10.1101/gad.1893610  1
2009 Beckerman R, Donner AJ, Mattia M, Peart MJ, Manley JL, Espinosa JM, Prives C. A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes & Development. 23: 1364-77. PMID 19487575 DOI: 10.1101/gad.1795709  0.8
2009 Knuesel MT, Meyer KD, Donner AJ, Espinosa JM, Taatjes DJ. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Molecular and Cellular Biology. 29: 650-61. PMID 19047373 DOI: 10.1128/MCB.00993-08  0.8
2008 Espinosa JM. Histone H2B ubiquitination: the cancer connection. Genes & Development. 22: 2743-9. PMID 18923072 DOI: 10.1101/gad.1732108  0.8
2008 Meyer KD, Donner AJ, Knuesel MT, York AG, Espinosa JM, Taatjes DJ. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3. The Embo Journal. 27: 1447-57. PMID 18418385 DOI: 10.1038/emboj.2008.78  0.8
2007 Donner AJ, Hoover JM, Szostek SA, Espinosa JM. Stimulus-specific transcriptional regulation within the p53 network. Cell Cycle (Georgetown, Tex.). 6: 2594-8. PMID 17957141  0.8
2007 Kalet BT, McBryde MB, Espinosa JM, Koch TH. Doxazolidine induction of apoptosis by a topoisomerase II independent mechanism. Journal of Medicinal Chemistry. 50: 4493-500. PMID 17696516 DOI: 10.1021/jm070569b  0.8
2007 Donner AJ, Szostek S, Hoover JM, Espinosa JM. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Molecular Cell. 27: 121-33. PMID 17612495 DOI: 10.1016/j.molcel.2007.05.026  0.8
2006 Gomes NP, Bjerke G, Llorente B, Szostek SA, Emerson BM, Espinosa JM. Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program. Genes & Development. 20: 601-12. PMID 16510875 DOI: 10.1101/gad.1398206  0.8
2005 Gómez EB, Espinosa JM, Forsburg SL. Schizosaccharomyces pombe mst2+ encodes a MYST family histone acetyltransferase that negatively regulates telomere silencing. Molecular and Cellular Biology. 25: 8887-903. PMID 16199868 DOI: 10.1128/MCB.25.20.8887-8903.2005  0.8
2003 Espinosa JM, Verdun RE, Emerson BM. p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage. Molecular Cell. 12: 1015-27. PMID 14580351 DOI: 10.1016/S1097-2765(03)00359-9  0.8
2003 Espinosa JM, Portal D, Lobo GS, Pereira CA, Alonso GD, Gómez EB, Lan GH, Pomar RV, Flawiá MM, Torres HN. Trypanosoma cruzi poly-zinc finger protein: a novel DNA/RNA-binding CCHC-zinc finger protein. Molecular and Biochemical Parasitology. 131: 35-44. PMID 12967710 DOI: 10.1016/S0166-6851(03)00187-7  0.8
2003 Portal D, Espinosa JM, Lobo GS, Kadener S, Pereira CA, De La Mata M, Tang Z, Lin RJ, Kornblihtt AR, Baralle FE, Flawiá MM, Torres HN. An early ancestor in the evolution of splicing: a Trypanosoma cruzi serine-arginine-rich protein (TcSR) is functional in cis-splicing. Molecular and Biochemical Parasitology. 127: 37-46. PMID 12615334 DOI: 10.1016/S0166-6851(02)00301-8  0.8
2003 Portal D, Lobo GS, Kadener S, Prasad J, Espinosa JM, Pereira CA, Tang Z, Lin RJ, Manley JL, Kornblihtt AR, Flawiá MM, Torres HN. Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Molecular and Biochemical Parasitology. 127: 9-21. PMID 12615332 DOI: 10.1016/S0166-6851(02)00299-2  0.8
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