Colleen Clancy - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
General Biophysics, Neuroscience Biology, Animal Physiology Biology

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, ... ... Clancy CE, et al. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clinical Pharmacology and Therapeutics. PMID 31709525 DOI: 10.1002/cpt.1647  0.64
2019 Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. The Journal of Physiology. PMID 31278749 DOI: 10.1113/JP277724  0.64
2019 Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altinas I, Amaro RE, Clancy CE. A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows. Plos Computational Biology. 15: e1006856. PMID 30849072 DOI: 10.1371/journal.pcbi.1006856  0.64
2018 Agarwal SR, Gratwohl J, Cozad M, Yang PC, Clancy CE, Harvey RD. Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes. Frontiers in Pharmacology. 9: 332. PMID 29740315 DOI: 10.3389/fphar.2018.00332  0.64
2018 Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Frontiers in Physiology. 9: 207. PMID 29706893 DOI: 10.3389/fphys.2018.00207  0.64
2018 DeMarco KR, Bekker S, Clancy CE, Noskov SY, Vorobyov I. Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. Frontiers in Pharmacology. 9: 26. PMID 29449809 DOI: 10.3389/fphar.2018.00026  0.48
2017 Sato D, Clancy CE, Bers DM. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 3: e00388. PMID 28924617 DOI: 10.1016/j.heliyon.2017.e00388  0.64
2017 Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE. A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. The Journal of Physiology. PMID 28516454 DOI: 10.1113/JP273142  0.64
2016 Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, et al. Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology. PMID 27808412 DOI: 10.1113/JP272883  0.64
2016 Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. The Journal of Physiology. 594: 6433-6435. PMID 27800622 DOI: 10.1113/JP273143  1
2016 Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. Journal of Molecular and Cellular Cardiology. PMID 27545042 DOI: 10.1016/j.yjmcc.2016.08.011  0.92
2016 Yang PC, Boras BW, Jeng MT, Docken SS, Lewis TJ, McCulloch AD, Harvey RD, Clancy CE. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation. Plos Computational Biology. 12: e1005005. PMID 27409243 DOI: 10.1371/journal.pcbi.1005005  0.92
2016 Gray B, Bagnall RD, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang PC, Clancy CE, Sy RW, Semsarian C. A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm : the Official Journal of the Heart Rhythm Society. PMID 27157848 DOI: 10.1016/j.hrthm.2016.05.004  0.92
2016 Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Annals of Biomedical Engineering. PMID 27138523 DOI: 10.1007/s10439-016-1628-0  0.92
2016 Moreno JD, Lewis TJ, Clancy CE. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. Plos One. 11: e0150761. PMID 26963710 DOI: 10.1371/journal.pone.0150761  0.92
2016 Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM. Multiscale Modeling in the Clinic: Drug Design and Development. Annals of Biomedical Engineering. PMID 26885640 DOI: 10.1007/s10439-016-1563-0  0.92
2016 Agarwal SR, Clancy CE, Harvey RD. Mechanisms Restricting Diffusion of Intracellular cAMP. Scientific Reports. 6: 19577. PMID 26795432 DOI: 10.1038/srep19577  0.92
2015 Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 87: 271-82. PMID 26859003  0.64
2015 Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov S, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology. PMID 26515697 DOI: 10.1113/JP271282  0.92
2015 Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. The Journal of Biological Chemistry. PMID 26515070 DOI: 10.1074/jbc.M115.668236  0.92
2015 Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophysical Journal. 108: 1414-24. PMID 25809254 DOI: 10.1016/j.bpj.2014.12.056  0.92
2015 Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, et al. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. The Journal of Physiology. 593: 1361-82. PMID 25772291 DOI: 10.1113/jphysiol.2014.282319  0.92
2015 Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, ... ... Clancy CE, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/jphysiol.2014.281428  0.92
2015 Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, et al. Deranged sodium to sudden death. The Journal of Physiology. 593: 1331-45. PMID 25772289 DOI: 10.1113/jphysiol.2014.281204  0.92
2015 Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. The Journal of Physiology. 593: 1429-42. PMID 25545172 DOI: 10.1113/jphysiol.2014.279554  0.64
2014 Yarov-Yarovoy V, Allen TW, Clancy CE. Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discovery Today. Disease Models. 14: 3-10. PMID 26635886 DOI: 10.1016/j.ddmod.2014.04.001  0.92
2014 Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD. Role of membrane microdomains in compartmentation of cAMP signaling. Plos One. 9: e95835. PMID 24752595 DOI: 10.1371/journal.pone.0095835  0.92
2014 Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 72: 126-37. PMID 24631769 DOI: 10.1016/j.yjmcc.2014.02.018  0.64
2013 Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circulation Research. 113: e50-61. PMID 23897695 DOI: 10.1161/CIRCRESAHA.113.301971  0.92
2013 Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. Journal of Cardiovascular Electrophysiology. 24: 1021-7. PMID 23631727 DOI: 10.1111/jce.12163  0.92
2012 Lewin N, Aksay E, Clancy CE. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. Plos One. 7: e47250. PMID 23071770 DOI: 10.1371/journal.pone.0047250  0.64
2012 Yang PC, Clancy CE. In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias. Frontiers in Physiology. 3: 360. PMID 23049511 DOI: 10.3389/fphys.2012.00360  0.64
2012 Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE. Computational approaches to understand cardiac electrophysiology and arrhythmias. American Journal of Physiology. Heart and Circulatory Physiology. 303: H766-83. PMID 22886409 DOI: 10.1152/ajpheart.01081.2011  1
2012 Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. Journal of Molecular and Cellular Cardiology. 52: 608-19. PMID 22198344 DOI: 10.1016/j.yjmcc.2011.12.003  1
2011 Yang PC, Clancy CE. Gender-based differences in cardiac diseases. Journal of Biomedical Research. 25: 81-9. PMID 23554675 DOI: 10.1016/S1674-8301(11)60010-9  0.64
2011 Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Science Translational Medicine. 3: 98ra83. PMID 21885405 DOI: 10.1126/scitranslmed.3002588  0.92
2010 Oren RV, Clancy CE. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. Plos Computational Biology. 6: e1001041. PMID 21203483 DOI: 10.1371/journal.pcbi.1001041  1
2010 Yang PC, Clancy CE. Effects of sex hormones on cardiac repolarization. Journal of Cardiovascular Pharmacology. 56: 123-9. PMID 20164789 DOI: 10.1097/FJC.0b013e3181d6f7dd  0.64
2010 Yang PC, Kurokawa J, Furukawa T, Clancy CE. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. Plos Computational Biology. 6: e1000658. PMID 20126530 DOI: 10.1371/journal.pcbi.1000658  0.64
2010 Protas L, Oren RV, Clancy CE, Robinson RB. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. Journal of Molecular and Cellular Cardiology. 48: 172-80. PMID 19665465 DOI: 10.1016/j.yjmcc.2009.07.028  1
2009 Moreno JD, Clancy CE. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discovery Today. Disease Models. 6: 71-84. PMID 20652086 DOI: 10.1016/j.ddmod.2010.03.001  1
2009 Ahrens-Nicklas RC, Clancy CE, Christini DJ. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling. Cardiovascular Research. 82: 439-47. PMID 19264765 DOI: 10.1093/cvr/cvp083  0.92
2009 Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. The Journal of Physiology. 587: 1513-25. PMID 19171659 DOI: 10.1113/jphysiol.2008.163444  1
2008 Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 118: 1202-11. PMID 18779456 DOI: 10.1161/CIRCULATIONAHA.108.772715  0.92
2007 Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 116: 2913-22. PMID 18056530 DOI: 10.1161/CIRCULATIONAHA.107.702407  1
2007 Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, et al. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 116: 2325-45. PMID 17998470 DOI: 10.1161/CIRCULATIONAHA.107.711689  0.92
2007 Zhu ZI, Clancy CE. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. Journal of Electrocardiology. 40: S47-50. PMID 17993328 DOI: 10.1016/j.jelectrocard.2007.05.033  0.36
2007 Zhu ZI, Clancy CE. L-type Ca2+ channel mutations and T-wave alternans: a model study. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3480-9. PMID 17933974 DOI: 10.1152/ajpheart.00476.2007  0.36
2007 Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. International Journal of Cardiology. 121: 249-52. PMID 17761312 DOI: 10.1016/j.ijcard.2007.05.060  0.4
2007 Clancy CE, Zhu ZI, Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. American Journal of Physiology. Heart and Circulatory Physiology. 292: H66-75. PMID 16997895 DOI: 10.1152/ajpheart.00312.2006  0.92
2006 Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Human Molecular Genetics. 15: 2888-902. PMID 16923798 DOI: 10.1093/hmg/ddl230  0.92
2005 Zhu ZI, Clancy CE. From mutation to clinical presentation: mechanisms in the black box. Journal of Molecular and Cellular Cardiology. 38: 965-8. PMID 15878172 DOI: 10.1016/j.yjmcc.2005.03.011  0.36
2005 Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circulation Research. 96: e25-34. PMID 15731462 DOI: 10.1161/01.RES.0000160555.58046.9a  0.92
2005 Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy CE, Escande D, et al. Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovascular Research. 65: 128-37. PMID 15621040 DOI: 10.1016/j.cardiores.2004.09.030  0.68
2005 Clancy CE, Kass RS. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiological Reviews. 85: 33-47. PMID 15618477 DOI: 10.1152/physrev.00005.2004  0.92
2004 Clancy CE, Kass RS. Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical Journal. 86: 2606-14. PMID 15041696 DOI: 10.1016/S0006-3495(04)74315-5  0.92
2003 Glaaser IW, Kass RS, Clancy CE. Mechanisms of genetic arrhythmias: from DNA to ECG. Progress in Cardiovascular Diseases. 46: 259-70. PMID 14685943 DOI: 10.1016/S0033-0620(03)00073-2  0.92
2003 Clancy CE, Kass RS. Pharmacogenomics in the treatment of epilepsy. Pharmacogenomics. 4: 747-51. PMID 14596638 DOI: 10.1517/phgs.4.6.747.22822  0.92
2003 Tateyama M, Rivolta I, Clancy CE, Kass RS. Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation. The Journal of Biological Chemistry. 278: 46718-26. PMID 14500710 DOI: 10.1074/jbc.M308977200  0.92
2003 Liu H, Clancy CE, Cormier JW, Kass RS. Mutations in cardiac sodium channels: Clinical implications American Journal of Pharmacogenomics. 3: 173-179. PMID 12814325 DOI: 10.2165/00129785-200303030-00003  0.92
2003 Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 107: 2233-7. PMID 12695286 DOI: 10.1161/01.CIR.0000069273.51375.BD  0.92
2003 Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annual Review of Pharmacology and Toxicology. 43: 441-61. PMID 12540747 DOI: 10.1146/annurev.pharmtox.43.100901.140245  0.92
2002 Clancy CE, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. The Journal of Clinical Investigation. 110: 1251-62. PMID 12417563 DOI: 10.1172/JCI15928  0.92
2002 Clancy CE, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. The Journal of Clinical Investigation. 110: 1075-7. PMID 12393842 DOI: 10.1172/JCI16945  0.92
2002 Rivolta I, Clancy CE, Tateyama M, Liu H, Priori SG, Kass RS. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiological Genomics. 10: 191-7. PMID 12209021 DOI: 10.1152/physiolgenomics.00039.2002  0.92
2002 Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (New York, N.Y.). 297: 1333-6. PMID 12193783 DOI: 10.1126/science.1073569  0.92
2002 Liu H, Tateyama M, Clancy CE, Abriel H, Kass RS. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. The Journal of General Physiology. 120: 39-51. PMID 12084774 DOI: 10.1085/jgp.20028558  0.92
2002 Clancy CE, Rudy Y. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105: 1208-13. PMID 11889015 DOI: 10.1161/hc1002.105183  0.92
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