Jorge Ghiso - Publications

Affiliations: 
Basic Medical Science New York University, New York, NY, United States 
Area:
Pathology, Neuroscience Biology

196 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Arber C, Casey JM, Crawford S, Rambarack N, Yaman U, Wiethoff S, Augustin E, Piers TM, Rostagno A, Ghiso J, Lewis PA, Revesz T, Hardy J, Pocock JM, Houlden H, et al. Microglia produce the amyloidogenic ABri peptide in familial British dementia. Biorxiv : the Preprint Server For Biology. PMID 37425748 DOI: 10.1101/2023.06.27.546552  0.405
2022 Rostagno A, Cabrera E, Lashley T, Ghiso J. N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer's pathophysiology. Translational Neurodegeneration. 11: 30. PMID 35641972 DOI: 10.1186/s40035-022-00303-3  0.49
2022 Rostagno A, Calero M, Ghiso J. Identification of Clusterin as a Major ABri- and ADan-Binding Protein Using Affinity Chromatography. Methods in Molecular Biology (Clifton, N.J.). 2466: 49-60. PMID 35585310 DOI: 10.1007/978-1-0716-2176-9_4  0.448
2021 Rostagno A, Calero M, Holton JL, Revesz T, Lashley T, Ghiso J. Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan. Neurobiology of Disease. 158: 105452. PMID 34298087 DOI: 10.1016/j.nbd.2021.105452  0.466
2021 Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, ... ... Ghiso J, et al. Correction: Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. Molecular Psychiatry. PMID 34272490 DOI: 10.1038/s41380-021-01206-x  0.357
2020 Parodi-Rullán R, Ghiso J, Cabrera E, Rostagno A, Fossati S. Alzheimer's amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis. Aging Cell. e13258. PMID 33155752 DOI: 10.1111/acel.13258  0.504
2020 Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, O'Brien NL, Groet J, Shao X, Havlicek S, Dunn NR, ... ... Ghiso J, et al. Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. Molecular Psychiatry. PMID 32647257 DOI: 10.1038/S41380-020-0806-5  0.53
2020 Karkisaval AG, Rostagno A, Azimov R, Ban DK, Ghiso J, Kagan BL, Lal R. Ion channel formation by N-terminally truncated Aβ (4-42): Relevance for the pathogenesis of Alzheimer's disease. Nanomedicine : Nanotechnology, Biology, and Medicine. 102235. PMID 32531337 DOI: 10.1016/J.Nano.2020.102235  0.547
2020 Zampar S, Klafki HW, Sritharen K, Bayer TA, Wiltfang J, Rostagno A, Ghiso J, A Miles L, Wirths O. N-terminal heterogeneity of parenchymal and vascular amyloid-β deposits in Alzheimer's disease. Neuropathology and Applied Neurobiology. PMID 32497293 DOI: 10.1111/Nan.12637  0.575
2020 Sotolongo K, Ghiso J, Rostagno A. Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage. Alzheimer's Research & Therapy. 12: 13. PMID 31931869 DOI: 10.1186/S13195-019-0578-9  0.442
2020 Ghiso J, Cabrera E, Neubert TA, Rostagno A. N‐ and C‐Terminal Alzheimer’s Aβ Heterogeneity Modulates the Balance Between Brain Clearance and Amyloid Formation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02002  0.536
2018 Murray CE, Gami-Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Wirths O, Heywood W, Blennow K, Ghiso J, Holton JL, Mills K, Zetterberg H, Revesz T, Lashley T. The presubiculum is preserved from neurodegenerative changes in Alzheimer's disease. Acta Neuropathologica Communications. 6: 62. PMID 30029687 DOI: 10.1186/S40478-018-0563-8  0.581
2018 Rostagno A, Neubert TA, Ghiso J. Unveiling Brain Aβ Heterogeneity Through Targeted Proteomic Analysis. Methods in Molecular Biology (Clifton, N.J.). 1779: 23-43. PMID 29886525 DOI: 10.1007/978-1-4939-7816-8_3  0.542
2017 Wirths O, Walter S, Kraus I, Klafki HW, Stazi M, Oberstein TJ, Ghiso J, Wiltfang J, Bayer TA, Weggen S. N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models. Alzheimer's Research & Therapy. 9: 80. PMID 28978359 DOI: 10.1186/S13195-017-0309-Z  0.562
2017 Cabrera E, Mathews P, Mezhericher E, Beach TG, Deng J, Neubert TA, Rostagno A, Ghiso J. Aβ truncated species: Implications for brain clearance mechanisms and amyloid plaque deposition. Biochimica Et Biophysica Acta. PMID 28711595 DOI: 10.1016/J.Bbadis.2017.07.005  0.556
2017 Murray CE, Gami-Patel P, Gkanatsiou E, Brinkmalm G, Portelius E, Blennow K, Ghiso J, Holton J, Zetterberg H, Revesz T, Lashley T. Is The Presubiculum Protected From Neurodegenerative Changes? A Pathological And Biochemical Investigation Alzheimers & Dementia. 13: 668. DOI: 10.1016/J.Jalz.2017.06.809  0.308
2016 McIntee FL, Giannoni P, Blais S, Sommer G, Neubert TA, Rostagno A, Ghiso J. In vivo Differential Brain Clearance and Catabolism of Monomeric and Oligomeric Alzheimer's Aβ protein. Frontiers in Aging Neuroscience. 8: 223. PMID 27729857 DOI: 10.3389/Fnagi.2016.00223  0.782
2016 Rosen RF, Tomidokoro Y, Farberg AS, Dooyema J, Ciliax B, Preuss TM, Neubert TA, Ghiso JA, LeVine H, Walker LC. Comparative pathobiology of β-amyloid and the unique susceptibility of humans to Alzheimer's disease. Neurobiology of Aging. 44: 185-96. PMID 27318146 DOI: 10.1016/J.Neurobiolaging.2016.04.019  0.489
2016 Fossati S, Giannoni P, Solesio ME, Cocklin SL, Cabrera E, Ghiso J, Rostagno A. The carbonic anhydrase inhibitor methazolamide prevents amyloid beta-induced mitochondrial dysfunction and caspase activation protecting neuronal and glial cells in vitro and in the mouse brain. Neurobiology of Disease. 86: 29-40. PMID 26581638 DOI: 10.1016/J.Nbd.2015.11.006  0.462
2016 Todd K, Ghiso J, Rostagno A. Oxidative stress and mitochondria-mediated cell death mechanisms triggered by the familial Danish dementia ADan amyloid. Neurobiology of Disease. 85: 130-43. PMID 26459115 DOI: 10.1016/J.Nbd.2015.10.003  0.524
2016 Pasinetti GM, Ghiso J, Ho L. P1-093: Characterization of Novel Bioavailable Bioactive Polyphenolic Compounds for Pharmacological Preservation of Blood Brain Barrier Function in Alzheimer’s Disease Alzheimer's & Dementia. 12: P436-P437. DOI: 10.1016/J.Jalz.2016.06.841  0.339
2015 Hernandez-Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert TA, Rostagno A, Ghiso J. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. The Journal of Biological Chemistry. 290: 15078-91. PMID 25897080 DOI: 10.1074/Jbc.M114.610931  0.462
2015 Fossati S, Giannoni P, Solesio ME, Cocklin SL, Cabrera E, Ghiso J, Rostagno A. Methazolamide protects neuronal and glial cells from amyloid toxicity in vitro and in vivo via mitochondria-mediated mechanisms Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.08.037  0.361
2014 Todd K, Fossati S, Ghiso J, Rostagno A. Mitochondrial dysfunction induced by a post-translationally modified amyloid linked to a familial mutation in an alternative model of neurodegeneration. Biochimica Et Biophysica Acta. 1842: 2457-67. PMID 25261792 DOI: 10.1016/J.Jalz.2014.05.346  0.516
2014 Ghiso J, Fossati S, Rostagno A. Amyloidosis associated with cerebral amyloid angiopathy: cell signaling pathways elicited in cerebral endothelial cells. Journal of Alzheimer's Disease : Jad. 42: S167-76. PMID 24670400 DOI: 10.3233/Jad-140027  0.535
2014 Doudevski I, Rostagno A, Cowman M, Liebmann J, Ritch R, Ghiso J. Clusterin and complement activation in exfoliation glaucoma. Investigative Ophthalmology & Visual Science. 55: 2491-9. PMID 24550356 DOI: 10.1167/Iovs.13-12941  0.314
2014 Fossati S, Giannoni P, Hernandez-Guillamon M, Montaner J, Ghiso J, Rostagno A. Mitochondria And Death Receptors: Key Targets For Amyloid Toxicity In The Cerebral Vasculature Alzheimers & Dementia. 10: 191. DOI: 10.1016/J.Jalz.2014.04.222  0.359
2013 Fossati S, Todd K, Sotolongo K, Ghiso J, Rostagno A. Differential contribution of isoaspartate post-translational modifications to the fibrillization and toxic properties of amyloid β and the Asn23 Iowa mutation. The Biochemical Journal. 456: 347-60. PMID 24028142 DOI: 10.1042/Bj20130652  0.516
2013 Ghiso JA, Doudevski I, Ritch R, Rostagno AA. Alzheimer's disease and glaucoma: mechanistic similarities and differences. Journal of Glaucoma. 22: S36-8. PMID 23733125 DOI: 10.1097/Ijg.0B013E3182934Af6  0.406
2013 Tsachaki M, Fotinopoulou A, Slavi N, Zarkou V, Ghiso J, Efthimiopoulos S. BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels. Current Alzheimer Research. 10: 532-41. PMID 23701002 DOI: 10.2174/1567205011310050009  0.395
2013 Pinnix I, Ghiso JA, Pappolla MA, Sambamurti K. Major carboxyl terminal fragments generated by γ-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 21: 474-83. PMID 23570890 DOI: 10.1016/J.Jagp.2013.02.009  0.333
2013 Saul A, Lashley T, Revesz T, Holton J, Ghiso JA, Coomaraswamy J, Wirths O. Abundant pyroglutamate-modified ABri and ADan peptides in extracellular and vascular amyloid deposits in familial British and Danish dementias. Neurobiology of Aging. 34: 1416-25. PMID 23261769 DOI: 10.1016/j.neurobiolaging.2012.11.014  0.346
2012 Fossati S, Ghiso J, Rostagno A. TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aβ. Cell Death and Disease. 3. PMID 22695614 DOI: 10.1038/Cddis.2012.55  0.405
2012 Calero M, Rostagno A, Ghiso J. Search for amyloid-binding proteins by affinity chromatography. Methods in Molecular Biology (Clifton, N.J.). 849: 213-23. PMID 22528093 DOI: 10.1007/978-1-61779-551-0_15  0.473
2012 Morales-Corraliza J, Berger JD, Mazzella MJ, Veeranna, Neubert TA, Ghiso J, Rao MV, Staufenbiel M, Nixon RA, Mathews PM. Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice. Neurobiology of Aging. 33: 1125.e9-18. PMID 22206846 DOI: 10.1016/J.Neurobiolaging.2011.11.023  0.434
2012 Fossati S, Ghiso J, Rostagno A. Insights into caspase-mediated apoptotic pathways induced by amyloid-β in cerebral microvascular endothelial cells. Neuro-Degenerative Diseases. 10: 324-8. PMID 22156599 DOI: 10.1159/000332821  0.492
2011 Tsachaki M, Serlidaki D, Fetani A, Zarkou V, Rozani I, Ghiso J, Efthimiopoulos S. Glycosylation of BRI2 on asparagine 170 is involved in its trafficking to the cell surface but not in its processing by furin or ADAM10. Glycobiology. 21: 1382-8. PMID 21752865 DOI: 10.1093/Glycob/Cwr097  0.305
2010 Tomidokoro Y, Tamaoka A, Holton JL, Lashley T, Frangione B, Revesz T, Rostagno A, Ghiso J. PYROGLUTAMATE FORMATION AT THE N-TERMINI OF ABRI MOLECULES IN FAMILIAL BRITISH DEMENTIA IS NOT RESTRICTED TO THE CENTRAL NERVOUS SYSTEM. Hirosaki Igaku = Hirosaki Medical Journal. 61: S262-S269. PMID 21037969  0.402
2010 Ghiso J, Tomidokoro Y, Revesz T, Frangione B, Rostagno A. CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE. Hirosaki Igaku = Hirosaki Medical Journal. 61: S111-S124. PMID 21037967  0.466
2010 Hu Y, Su B, Kim CS, Hernandez M, Rostagno A, Ghiso J, Kim JR. A strategy for designing a peptide probe for detection of β-amyloid oligomers. Chembiochem : a European Journal of Chemical Biology. 11: 2409-18. PMID 21031399 DOI: 10.1002/cbic.201000435  0.415
2010 Hernandez-Guillamon M, Mawhirt S, Fossati S, Blais S, Pares M, Penalba A, Boada M, Couraud PO, Neubert TA, Montaner J, Ghiso J, Rostagno A. Matrix metalloproteinase 2 (MMP-2) degrades soluble vasculotropic amyloid-beta E22Q and L34V mutants, delaying their toxicity for human brain microvascular endothelial cells. The Journal of Biological Chemistry. 285: 27144-58. PMID 20576603 DOI: 10.1074/Jbc.M110.135228  0.414
2010 Sharman MJ, Morici M, Hone E, Berger T, Taddei K, Martins IJ, Lim WL, Singh S, Wenk MR, Ghiso J, Buxbaum JD, Gandy S, Martins RN. APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice. Journal of Alzheimer's Disease : Jad. 21: 403-9. PMID 20555142 DOI: 10.3233/Jad-2010-100141  0.448
2010 Rosen RF, Tomidokoro Y, Ghiso JA, Walker LC. SDS-PAGE/immunoblot detection of Abeta multimers in human cortical tissue homogenates using antigen-epitope retrieval. Journal of Visualized Experiments : Jove. PMID 20418805 DOI: 10.3791/1916  0.424
2010 Coomaraswamy J, Kilger E, Wölfing H, Schäfer C, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, et al. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 7969-74. PMID 20385796 DOI: 10.1073/Pnas.1001056107  0.554
2010 Tomidokoro Y, Rostagno A, Neubert TA, Lu Y, Rebeck GW, Frangione B, Greenberg SM, Ghiso J. Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AbetaD23N in parenchymal and cerebrovascular amyloid deposits. The American Journal of Pathology. 176: 1841-54. PMID 20228223 DOI: 10.2353/Ajpath.2010.090636  0.581
2010 Sharman MJ, Shui G, Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum JD, Gandy S, Wenk MR, Martins RN. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry. Journal of Alzheimer's Disease : Jad. 20: 105-11. PMID 20164599 DOI: 10.3233/Jad-2010-1348  0.329
2010 Rostagno A, Holton JL, Lashley T, Revesz T, Ghiso J. Cerebral amyloidosis: amyloid subunits, mutants and phenotypes. Cellular and Molecular Life Sciences : Cmls. 67: 581-600. PMID 19898742 DOI: 10.1007/S00018-009-0182-4  0.512
2010 Rosen RF, Ciliax BJ, Wingo TS, Gearing M, Dooyema J, Lah JJ, Ghiso JA, LeVine H, Walker LC. Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease. Acta Neuropathologica. 119: 221-33. PMID 19690877 DOI: 10.1007/S00401-009-0583-3  0.431
2010 Tsachaki M, Ghiso J, Rostagno A, Efthimiopoulos S. BRI2 homodimerizes with the involvement of intermolecular disulfide bonds. Neurobiology of Aging. 31: 88-98. PMID 18440095 DOI: 10.1016/J.Neurobiolaging.2008.03.004  0.426
2010 Rostagno A, Fossati S, Ghiso J. Fibrillogenesis and toxicity of Iowa-Aβ amyloid is primarily driven by the D23N mutation Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.788  0.474
2010 Giannoni P, McIntee F, Gandy SE, Rostagno A, Ghiso J. P1-195: Involvement of the choroid plexus in the clearance of Aβ Alzheimer's & Dementia. 6: S230-S230. DOI: 10.1016/J.Jalz.2010.05.745  0.752
2010 Tomidokoro Y, Tamaoka A, Holton JL, Lashley T, Frangione B, Revesz T, Rostagno A, Ghiso J. Pyroglutamate formation at the N-termini of ABri molecules in familial British dementia occurs at the sites of deposition and is not restricted to the central nervous system Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.585  0.335
2010 Coomaraswamy J, Kilger E, Woelfing H, Schaefer C, Kaeser SA, Wegenast-Braun B, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, et al. Modeling familial danish dementia: Implications for the amyloid hypothesis of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.492  0.466
2010 McIntee FL, Blais S, Neubert T, Mathews P, Rostagno A, Ghiso J. P3-212: Catabolism of Alzheimer's amyloid-β: Implications for brain clearance and plaque deposition Alzheimer's & Dementia. 6: S513-S513. DOI: 10.1016/J.Jalz.2010.05.1711  0.779
2010 Fossati S, Ghiso J, Rostagno A. Molecular analysis of apoptotic pathways induced by amyloid-β variants in cerebral vascular cells Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1264  0.397
2009 Rostagno A, Ghiso J. Isolation and biochemical characterization of amyloid plaques and paired helical filaments. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 3.33 3.33.1-33. PMID 19731227 DOI: 10.1002/0471143030.Cb0333S44  0.541
2009 Revesz T, Holton JL, Lashley T, Plant G, Frangione B, Rostagno A, Ghiso J. Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies. Acta Neuropathologica. 118: 115-30. PMID 19225789 DOI: 10.1007/S00401-009-0501-8  0.492
2009 Viana RJS, Nunes AF, Castro RE, Ramalho RM, Meyerson J, Fossati S, Ghiso J, Rostagno A, Rodrigues CMP. Tauroursodeoxycholic acid prevents E22Q Alzheimer’s Aβ toxicity in human cerebral endothelial cells Cellular and Molecular Life Sciences. 66: 1094-1104. PMID 19189048 DOI: 10.1007/S00018-009-8746-X  0.501
2009 Solito R, Corti F, Fossati S, Mezhericher E, Donnini S, Ghiso J, Giachetti A, Rostagno A, Ziche M. Dutch and Arctic mutant peptides of beta amyloid(1-40) differentially affect the FGF-2 pathway in brain endothelium. Experimental Cell Research. 315: 385-95. PMID 19061884 DOI: 10.1016/J.Yexcr.2008.11.002  0.458
2008 Tsachaki M, Ghiso J, Efthimiopoulos S. BRI2 as a central protein involved in neurodegeneration. Biotechnology Journal. 3: 1548-54. PMID 19072909 DOI: 10.1002/Biot.200800247  0.531
2008 Berry A, Tomidokoro Y, Ghiso J, Thornton J. Human chorionic gonadotropin (a luteinizing hormone homologue) decreases spatial memory and increases brain amyloid-beta levels in female rats. Hormones and Behavior. 54: 143-52. PMID 18413150 DOI: 10.1016/J.Yhbeh.2008.02.006  0.339
2008 Rostagno A, Ghiso J. Preamyloid lesions and cerebrovascular deposits in the mechanism of dementia: lessons from non-beta-amyloid cerebral amyloidosis. Neuro-Degenerative Diseases. 5: 173-5. PMID 18322382 DOI: 10.1159/000113694  0.567
2008 Lashley T, Revesz T, Plant G, Bandopadhyay R, Lees AJ, Frangione B, Wood NW, de Silva R, Ghiso J, Rostagno A, Holton JL. Expression of BRI2 mRNA and protein in normal human brain and familial British dementia: its relevance to the pathogenesis of disease. Neuropathology and Applied Neurobiology. 34: 492-505. PMID 18282158 DOI: 10.1111/J.1365-2990.2008.00935.X  0.52
2008 Hu AC, Bachmann T, Zhou G, Liang F, Ghiso J, Kreibich G, Sun T. ASSEMBLY OF UROTHELIAL PLAQUES AND ITS REGULATION Journal of Urology. 179: 79-80. DOI: 10.1016/S0022-5347(08)60233-5  0.316
2008 Coomaraswamy J, Woelfing H, Schaefer C, Kaeser SA, Akiyama H, Goedert M, Mathews PM, Ghiso J, Jucker M. P1-076: Modeling Familial Danish dementia Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.662  0.31
2007 Rostagno A, Lashley T, Ng D, Meyerson J, Braendgaard H, Plant G, Bojsen-Møller M, Holton J, Frangione B, Revesz T, Ghiso J. Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease. Journal of the Neurological Sciences. 257: 88-96. PMID 17374542 DOI: 10.1016/J.Jns.2007.01.050  0.59
2006 Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, et al. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (New York, N.Y.). 313: 1781-4. PMID 16990547 DOI: 10.1126/Science.1131864  0.498
2006 Lashley T, Holton JL, Verbeek MM, Rostagno A, Bojsen-Møller M, David G, van Horssen J, Braendgaard H, Plant G, Frangione B, Ghiso J, Revesz T. Molecular chaperons, amyloid and preamyloid lesions in the BRI2 gene-related dementias: a morphological study. Neuropathology and Applied Neurobiology. 32: 492-504. PMID 16972883 DOI: 10.1111/J.1365-2990.2006.00747.X  0.539
2006 Ghiso J, Rostagno A, Tomidokoro Y, Lashley T, Bojsen-Møller M, Braendgaard H, Plant G, Holton J, Lal R, Revesz T, Frangione B. Genetic alterations of the BRI2 gene: familial British and Danish dementias. Brain Pathology (Zurich, Switzerland). 16: 71-9. PMID 16612984 DOI: 10.1111/J.1750-3639.2006.Tb00563.X  0.533
2006 Carter TL, Pedrini S, Ghiso J, Ehrlich ME, Gandy S. Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis. Neuroscience Letters. 392: 235-9. PMID 16233955 DOI: 10.1016/J.Neulet.2005.09.022  0.429
2006 Coomaraswamy J, Herzig MC, Kaeser SA, Ghiso J, Jucker M. P1-072: Transgenic mouse models of familial British and Danish dementias Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.447  0.336
2006 Tomidokoro Y, Lashley T, Revesz T, Greenberg SM, Frangione B, Rostagno A, Ghiso J. P4-078: Matrix metalloproteases and Aβ clearance Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1816  0.406
2006 Cam JA, Meyerson JL, Ng D, Frangione B, Ghiso J, Rostagno A. P4-060: Oligomeric assemblies of the Aβ Dutch mutant induce the formation of nucleosomes in primary human cerebral endothelial cells Alzheimer's & Dementia. 2: S531-S531. DOI: 10.1016/J.Jalz.2006.05.1798  0.395
2006 Tsachaki M, Fotinopoulou A, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, Ghiso J, Efthimiopoulos S. O2-03-06: BRI2 modulates amyloid precursor protein processing and inhibits aβ generation Alzheimer's & Dementia. 2: S36-S36. DOI: 10.1016/J.Jalz.2006.05.125  0.428
2005 Rábano A, Jiménez-Huete A, Acevedo B, Calero M, Ghiso J, Valdés I, Gavilondo J, Frangione B, Méndez E. Diversity of senile plaques in Alzheimer's disease as revealed by a new monoclonal antibody that recognizes an internal sequence of the Abeta peptide. Current Alzheimer Research. 2: 409-17. PMID 16248846 DOI: 10.2174/156720505774330500  0.525
2005 Tomidokoro Y, Lashley T, Rostagno A, Neubert TA, Bojsen-Møller M, Braendgaard H, Plant G, Holton J, Frangione B, Révész T, Ghiso J. Familial Danish dementia: co-existence of Danish and Alzheimer amyloid subunits (ADan AND A{beta}) in the absence of compact plaques. The Journal of Biological Chemistry. 280: 36883-94. PMID 16091362 DOI: 10.1074/Jbc.M504038200  0.508
2005 Fotinopoulou A, Tsachaki M, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, Ghiso J, Efthimiopoulos S. BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. The Journal of Biological Chemistry. 280: 30768-72. PMID 16027166 DOI: 10.1074/Jbc.C500231200  0.514
2005 Quist A, Doudevski I, Lin H, Azimova R, Ng D, Frangione B, Kagan B, Ghiso J, Lal R. Amyloid ion channels: a common structural link for protein-misfolding disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 10427-32. PMID 16020533 DOI: 10.1073/Pnas.0502066102  0.433
2005 Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, Ghiso J, Frangione B, D'Adamio L. The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. The Journal of Biological Chemistry. 280: 28912-6. PMID 15983050 DOI: 10.1074/Jbc.C500217200  0.421
2005 Calero M, Ghiso J. Radiolabeling of amyloid-beta peptides. Methods in Molecular Biology (Clifton, N.J.). 299: 325-48. PMID 15980615 DOI: 10.1385/1-59259-874-9:325  0.384
2005 Rostagno A, Tomidokoro Y, Lashley T, Ng D, Plant G, Holton J, Frangione B, Revesz T, Ghiso J. Chromosome 13 dementias. Cellular and Molecular Life Sciences : Cmls. 62: 1814-25. PMID 15968464 DOI: 10.1007/S00018-005-5092-5  0.564
2005 Morelli L, Llovera RE, Alonso LG, Frangione B, de Prat-Gay G, Ghiso J, Castaño EM. Insulin-degrading enzyme degrades amyloid peptides associated with British and Danish familial dementia. Biochemical and Biophysical Research Communications. 332: 808-16. PMID 15913558 DOI: 10.1016/J.Bbrc.2005.05.020  0.448
2005 Calero M, Rostagno A, Frangione B, Ghiso J. Clusterin and Alzheimer's disease. Sub-Cellular Biochemistry. 38: 273-98. PMID 15709484  0.405
2005 Calero M, Rostagno A, Frangione B, Ghiso J. Clusterin and Alzheimer’s Disease Sub-Cellular Biochemistry. 38: 273-298. DOI: 10.1007/0-387-23226-5_14  0.476
2004 Morelli L, Llovera RE, Mathov I, Lue LF, Frangione B, Ghiso J, Castaño EM. Insulin-degrading enzyme in brain microvessels: proteolysis of amyloid {beta} vasculotropic variants and reduced activity in cerebral amyloid angiopathy. The Journal of Biological Chemistry. 279: 56004-13. PMID 15489232 DOI: 10.1074/Jbc.M407283200  0.564
2004 Ghiso J, Wisniewski T. An animal model of vascular amyloidosis. Nature Neuroscience. 7: 902-4. PMID 15332087 DOI: 10.1038/Nn0904-902  0.507
2004 Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, Rostagno A, Frangione B. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. The Journal of Biological Chemistry. 279: 45897-908. PMID 15322125 DOI: 10.1074/Jbc.M407668200  0.511
2004 Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, ... ... Ghiso J, et al. Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiology of Aging. 25: 833-41. PMID 15212837 DOI: 10.1016/J.Neurobiolaging.2003.10.004  0.501
2004 Reiss AB, Siller KA, Rahman MM, Chan ES, Ghiso J, de Leon MJ. Cholesterol in neurologic disorders of the elderly: stroke and Alzheimer's disease. Neurobiology of Aging. 25: 977-89. PMID 15212822 DOI: 10.1016/J.Neurobiolaging.2003.11.009  0.407
2004 Lashley T, Holton JL, Frangione B, Bandopadhyay R, Ghiso J, Rostagno A, Revesz T. P1-264 The possible origin of the amyloid peptides in the BRI2 gene-related dementias Neurobiology of Aging. 25: S171. DOI: 10.1016/S0197-4580(04)80577-3  0.449
2004 Rostagno A, Zhao Z, Ng D, Lashley T, Holton J, Frangione B, Revesz T, Ghiso J. P1-262 Familial British and Danish dementias: BRI2 gene and protein expression by human cerebral cells Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80575-X  0.333
2004 Morelli L, Llovera RE, Frangione B, Ghiso J, Castaño EM. P1-177 Insulin degrading enzyme from human brain microvessels degrades amyloid β and its flemish, Dutch and Italian vasculotropic variants Neurobiology of Aging. 25: S146. DOI: 10.1016/S0197-4580(04)80490-1  0.401
2004 Ghiso J. S5-02-02 Molecular pathology of non-Aβ cerebral amyloidosis Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80304-X  0.455
2004 Tomidokoro Y, Rostagno A, Greenberg SM, Frangione B, Rebeck WG, Ghiso J. O2-03-07 Biochemical analysis of Aβ amyloid deposits in the Iowa variant of Alzheimer's disease Neurobiology of Aging. 25: S38. DOI: 10.1016/S0197-4580(04)80125-8  0.509
2003 Srinivasan R, Jones EM, Liu K, Ghiso J, Marchant RE, Zagorski MG. pH-dependent amyloid and protofibril formation by the ABri peptide of familial British dementia. Journal of Molecular Biology. 333: 1003-23. PMID 14583196 DOI: 10.1016/J.Jmb.2003.09.001  0.469
2003 Revesz T, Ghiso J, Lashley T, Plant G, Rostagno A, Frangione B, Holton JL. Cerebral amyloid angiopathies: a pathologic, biochemical, and genetic view. Journal of Neuropathology and Experimental Neurology. 62: 885-98. PMID 14533778 DOI: 10.1093/Jnen/62.9.885  0.533
2003 Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, et al. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine. 9: 907-13. PMID 12808450 DOI: 10.1038/Nm890  0.5
2003 Matsubara E, Bryant-Thomas T, Pacheco Quinto J, Henry TL, Poeggeler B, Herbert D, Cruz-Sanchez F, Chyan YJ, Smith MA, Perry G, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson GL, ... Ghiso J, et al. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. Journal of Neurochemistry. 85: 1101-8. PMID 12753069 DOI: 10.1046/J.1471-4159.2003.01654.X  0.521
2003 Morelli L, Llovera R, Gonzalez SA, Affranchino JL, Prelli F, Frangione B, Ghiso J, Castano EM. Differential degradation of amyloid beta genetic variants associated with hereditary dementia or stroke by insulin-degrading enzyme. The Journal of Biological Chemistry. 278: 23221-6. PMID 12695513 DOI: 10.1074/Jbc.M300276200  0.527
2002 Matsubara E, Shoji M, Abe K, Frangione B, Ghiso J. Vascular Amyloidosis in Neurodegenerative Conditions. Drug News & Perspectives. 15: 439-444. PMID 12677179 DOI: 10.1358/Dnp.2002.15.7.840079  0.507
2002 Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascular Pharmacology. 38: 303-13. PMID 12529925 DOI: 10.1016/S1537-1891(02)00198-2  0.392
2002 Matsubara E, Shoji M, Murakami T, Abe K, Frangione B, Ghiso J. Platelet microparticles as carriers of soluble Alzheimer's amyloid beta (sAbeta). Annals of the New York Academy of Sciences. 977: 340-8. PMID 12480771 DOI: 10.1111/J.1749-6632.2002.Tb04836.X  0.462
2002 Ghiso J, Frangione B. Amyloidosis and Alzheimer's disease. Advanced Drug Delivery Reviews. 54: 1539-51. PMID 12453671 DOI: 10.1016/S0169-409X(02)00149-7  0.582
2002 Zhou Z, Relkin N, Ghiso J, Smith JD, Gandy S. Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro. Molecular Medicine (Cambridge, Mass.). 8: 376-81. PMID 12393935 DOI: 10.1007/Bf03402018  0.512
2002 Rostagno A, Revesz T, Lashley T, Tomidokoro Y, Magnotti L, Braendgaard H, Plant G, Bojsen-Møller M, Holton J, Frangione B, Ghiso J. Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. The Journal of Biological Chemistry. 277: 49782-90. PMID 12388551 DOI: 10.1074/Jbc.M206448200  0.412
2002 Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. Journal of Drug Targeting. 10: 359-68. PMID 12164385 DOI: 10.1080/10611860290031831  0.503
2002 Revesz T, Holton JL, Lashley T, Plant G, Rostagno A, Ghiso J, Frangione B. Sporadic and familial cerebral amyloid angiopathies. Brain Pathology (Zurich, Switzerland). 12: 343-57. PMID 12146803 DOI: 10.1111/J.1750-3639.2002.Tb00449.X  0.49
2002 Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiology of Aging. 23: 405-12. PMID 11959403 DOI: 10.1016/S0197-4580(01)00317-7  0.475
2002 Holton JL, Lashley T, Ghiso J, Braendgaard H, Vidal R, Guerin CJ, Gibb G, Hanger DP, Rostagno A, Anderton BH, Strand C, Ayling H, Plant G, Frangione B, Bojsen-Møller M, et al. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. Journal of Neuropathology and Experimental Neurology. 61: 254-67. PMID 11895040 DOI: 10.1093/Jnen/61.3.254  0.461
2002 Holton JL, Ghiso J, Lashley T, Ganguly M, Strand K, Rostagno A, Plant G, Frangione B, Revesz T. Familial British dementia (FBD): a cerebral amyloidosis with systemic amyloid deposition Neuropathology and Applied Neurobiology. 28: 148-148. DOI: 10.1046/J.1365-2990.2002.39286_2.X  0.575
2001 Ghiso J, Frangione B. Cerebral amyloidosis, amyloid angiopathy, and their relationship to stroke and dementia. Journal of Alzheimer's Disease : Jad. 3: 65-73. PMID 12214074 DOI: 10.3233/Jad-2001-3110  0.484
2001 Ghiso J, Révész T, Holton J, Rostagno A, Lashley T, Houlden H, Gibb G, Anderton B, Bek T, Bojsen-Møller M, Wood N, Vidal R, Braendgaard H, Plant G, Frangione B. Chromosome 13 dementia syndromes as models of neurodegeneration. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 277-84. PMID 11791622 DOI: 10.3109/13506120108993826  0.544
2001 Poeggeler B, Miravalle L, Zagorski MG, Wisniewski T, Chyan YJ, Zhang Y, Shao H, Bryant-Thomas T, Vidal R, Frangione B, Ghiso J, Pappolla MA. Melatonin reverses the profibrillogenic activity of apolipoprotein E4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 40: 14995-5001. PMID 11732920 DOI: 10.1021/Bi0114269  0.565
2001 Pappolla MA, Omar RA, Chyan YJ, Ghiso J, Hsiao K, Bozner P, Perry G, Smith MA, Cruz-Sanchez F. Induction of NADPH cytochrome P450 reductase by the Alzheimer beta-protein. Amyloid as a "foreign body". Journal of Neurochemistry. 78: 121-8. PMID 11432979 DOI: 10.1046/J.1471-4159.2001.00379.X  0.547
2001 Teng MH, Yin JY, Vidal R, Ghiso J, Kumar A, Rabenou R, Shah A, Jacobson DR, Tagoe C, Gallo G, Buxbaum J. Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis Laboratory Investigation. 81: 385-396. PMID 11310831 DOI: 10.1038/Labinvest.3780246  0.447
2001 Holton JL, Ghiso J, Lashley T, Rostagno A, Guerin CJ, Gibb G, Houlden H, Ayling H, Martinian L, Anderton BH, Wood NW, Vidal R, Plant G, Frangione B, Revesz T. Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia. The American Journal of Pathology. 158: 515-26. PMID 11159188 DOI: 10.1016/S0002-9440(10)63993-4  0.496
2000 Ghiso J, Vidal R, Rostagno A, Miravalle L, Holton JL, Mead S, Révész T, Plant G, Frangione B. Amyloidogenesis in familial British dementia is associated with a genetic defect on chromosome 13. Annals of the New York Academy of Sciences. 920: 84-92. PMID 11193180 DOI: 10.1111/J.1749-6632.2000.Tb06908.X  0.574
2000 Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. The Journal of Clinical Investigation. 106: 1489-99. PMID 11120756 DOI: 10.1172/Jci10498  0.452
2000 Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, et al. Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells. The Journal of Biological Chemistry. 275: 36794-802. PMID 10962005 DOI: 10.1074/Jbc.M006986200  0.43
2000 Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microscopy Research and Technique. 50: 305-15. PMID 10936885 DOI: 10.1002/1097-0029(20000815)50:4<305::Aid-Jemt10>3.0.Co;2-L  0.537
2000 Vidal R, Calero M, Piccardo P, Farlow MR, Unverzagt FW, Méndez E, Jiménez-Huete A, Beavis R, Gallo G, Gomez-Tortosa E, Ghiso J, Hyman BT, Frangione B, Ghetti B. Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele. Acta Neuropathologica. 100: 1-12. PMID 10912914 DOI: 10.1007/S004010051186  0.573
2000 Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nature Medicine. 6: 718. PMID 10888893 DOI: 10.1038/77397  0.448
2000 Frangione B, Vidal R, Rostagno A, Ghiso J. Familial cerebral amyloid angiopathies and dementia. Alzheimer Disease and Associated Disorders. 14: S25-30. PMID 10850727 DOI: 10.1097/00002093-200000001-00005  0.533
2000 Miravalle L, Tokuda T, Chiarle R, Giaccone G, Bugiani O, Tagliavini F, Frangione B, Ghiso J. Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells. The Journal of Biological Chemistry. 275: 27110-6. PMID 10821838 DOI: 10.1074/Jbc.M003154200  0.505
2000 Ghiso J, Vidal R, Rostagno A, Mead S, Révész T, Plant G, Frangione B. A newly formed amyloidogenic fragment due to a stop codon mutation causes familial British dementia. Annals of the New York Academy of Sciences. 903: 129-37. PMID 10818498 DOI: 10.1111/J.1749-6632.2000.Tb06359.X  0.495
2000 Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. The Biochemical Journal. 348: 359-65. PMID 10816430 DOI: 10.1042/0264-6021:3480359  0.503
2000 Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, Bojsen-Møller M, Braendgaard H, Plant G, Ghiso J, Frangione B. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proceedings of the National Academy of Sciences of the United States of America. 97: 4920-5. PMID 10781099 DOI: 10.1073/Pnas.080076097  0.495
2000 Mead S, James-Galton M, Revesz T, Doshi RB, Harwood G, Pan EL, Ghiso J, Frangione B, Plant G. Familial British dementia with amyloid angiopathy: early clinical, neuropsychological and imaging findings. Brain : a Journal of Neurology. 123: 975-91. PMID 10775542 DOI: 10.1093/Brain/123.5.975  0.373
2000 Askanas V, Engel WK, Alvarez RB, Frangione B, Ghiso J, Vidal R. Inclusion body myositis, muscle blood vessel and cardiac amyloidosis, and transthyretin Val122Ile allele. Annals of Neurology. 47: 544-9. PMID 10762172 DOI: 10.1002/1531-8249(200004)47:4<544::Aid-Ana24>3.0.Co;2-D  0.303
2000 Strazielle N, Ghersi-Egea JF, Ghiso J, Dehouck MP, Frangione B, Patlak C, Fenstermacher J, Gorevic P. In vitro evidence that beta-amyloid peptide 1-40 diffuses across the blood-brain barrier and affects its permeability. Journal of Neuropathology and Experimental Neurology. 59: 29-38. PMID 10744033 DOI: 10.1093/Jnen/59.1.29  0.518
2000 Vidal RG, Calero M, Ghiso J, Frangione B. BRI amyloid precursor protein isoforms. BRI2 is mutated in familial British dementia Neurobiology of Aging. 21: 13. DOI: 10.1016/S0197-4580(00)82737-2  0.414
2000 Miravalle L, Vidal RG, Calero M, Révész T, Plant G, Frangione B, Ghiso J. N-terminal pyroglutamate enhances the fibrillogenic properties of the ABRI peptide in familial British dementia Neurobiology of Aging. 21: 84. DOI: 10.1016/S0197-4580(00)82600-7  0.324
2000 Vidal RG, Révész T, Rostagno A, Bek T, Braendgaard H, Plant G, Ghiso J, Frangione B. A decamer duplication in the BRI gene originates a de-novo amyloid peptide that causes dementia in a Danish kindred Neurobiology of Aging. 21: 58. DOI: 10.1016/S0197-4580(00)82484-7  0.429
2000 Révész T, Holton JL, Vidal RG, Rostagno A, Lashley T, Plant G, Frangione B, Ghiso J. Cerebral deposition of ABRI amyloid in familial British dementia Neurobiology of Aging. 21: 191. DOI: 10.1016/S0197-4580(00)82203-4  0.465
1999 Rostagno A, Vidal R, Kaplan B, Chuba J, Kumar A, Elliott JI, Frangione B, Gallo G, Ghiso J. pH-dependent fibrillogenesis of a VkappaIII Bence Jones protein. British Journal of Haematology. 107: 835-43. PMID 10606892 DOI: 10.1046/J.1365-2141.1999.01778.X  0.337
1999 Vidal R, Goñi F, Stevens F, Aucouturier P, Kumar A, Frangione B, Ghiso J, Gallo G. Somatic mutations of the L12a gene in V-kappa(1) light chain deposition disease: potential effects on aberrant protein conformation and deposition. The American Journal of Pathology. 155: 2009-17. PMID 10595931 DOI: 10.1016/S0002-9440(10)65520-4  0.314
1999 Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). The Biochemical Journal. 344: 375-83. PMID 10567218 DOI: 10.1042/Bj3440375  0.327
1999 Pappolla MA, Chyan YJ, Poeggeler B, Bozner P, Ghiso J, LeDoux SP, Wilson GL. Alzheimer beta protein mediated oxidative damage of mitochondrial DNA: prevention by melatonin. Journal of Pineal Research. 27: 226-9. PMID 10551770 DOI: 10.1111/J.1600-079X.1999.Tb00619.X  0.496
1999 Kaplan B, Vidal R, Kumar A, Ghiso J, Gallo G. Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat. American Journal of Clinical Pathology. 112: 403-407. PMID 10478147 DOI: 10.1093/Ajcp/112.3.403  0.469
1999 Chyan YJ, Poeggeler B, Omar RA, Chain DG, Frangione B, Ghiso J, Pappolla MA. Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. The Journal of Biological Chemistry. 274: 21937-42. PMID 10419516 DOI: 10.1074/Jbc.274.31.21937  0.461
1999 Vidal R, Frangione B, Rostagno A, Mead S, Révész T, Plant G, Ghiso J. A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 399: 776-81. PMID 10391242 DOI: 10.1038/21637  0.488
1999 Matsubara E, Ghiso J, Frangione B, Amari M, Tomidokoro Y, Ikeda Y, Harigaya Y, Okamoto K, Shoji M. Lipoprotein-free amyloidogenic peptides in plasma are elevated in patients with sporadic Alzheimer's disease and Down's syndrome. Annals of Neurology. 45: 537-41. PMID 10211483 DOI: 10.1002/1531-8249(199904)45:4<537::Aid-Ana20>3.0.Co;2-2  0.362
1998 Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. The Journal of Clinical Investigation. 102: 734-43. PMID 9710442 DOI: 10.1172/Jci2029  0.427
1998 Pappolla M, Bozner P, Soto C, Shao H, Robakis NK, Zagorski M, Frangione B, Ghiso J. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. The Journal of Biological Chemistry. 273: 7185-8. PMID 9516407 DOI: 10.1074/Jbc.273.13.7185  0.529
1998 Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. Journal of Neurochemistry. 70: 210-5. PMID 9422364 DOI: 10.1046/J.1471-4159.1998.70010210.X  0.411
1997 Wisniewski T, Ghiso J, Frangione B. Biology of A beta amyloid in Alzheimer's disease. Neurobiology of Disease. 4: 313-28. PMID 9440120 DOI: 10.1006/Nbdi.1997.0147  0.464
1997 Kaplan B, Vidal R, Kumar A, Ghiso J, Frangione B, Gallo G. Amino-terminal identity of co-existent amyloid and non-amyloid immunoglobulin kappa light chain deposits. A human disease to study alterations of protein conformation. Clinical and Experimental Immunology. 110: 472-8. PMID 9409653 DOI: 10.1046/J.1365-2249.1997.4421454.X  0.461
1997 Ghiso J, Calero M, Matsubara E, Governale S, Chuba J, Beavis R, Wisniewski T, Frangione B. Alzheimer's soluble amyloid beta is a normal component of human urine. Febs Letters. 408: 105-8. PMID 9180278 DOI: 10.1016/S0014-5793(97)00400-6  0.446
1997 Pappolla MA, Solo C, Bozner P, Franuione B, Ghiso J. MELATONIN PREVENTS FORMATION OF β-SHEETS AND FIBRILS OF P-AMYLOID. A NEW THERAPY FOR AD? Journal of Neuropathology and Experimental Neurology. 56: 575. DOI: 10.1097/00005072-199705000-00028  0.485
1996 Rostagno A, Vidal R, Kumar A, Chuba J, Niederman G, Gold L, Frangione B, Ghiso J, Gallo G. Fibrillary glomerulonephritis related to serum fibrillar immunoglobulin-fibronectin complexes. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 28: 676-84. PMID 9158204 DOI: 10.1016/S0272-6386(96)90248-6  0.364
1996 Frangione B, Castaño EM, Wisniewski T, Ghiso J, Prelli F, Vidal R. Apolipoprotein E and amyloidogenesis. Ciba Foundation Symposium. 199: 132-41; discussion 1. PMID 8915608 DOI: 10.1002/9780470514924.Ch9  0.447
1996 Vidal R, Ghiso J, Wisniewski T, Frangione B. Alzheimer's presenilin 1 gene expression in platelets and megakaryocytes. Identification of a novel splice variant. Febs Letters. 393: 19-23. PMID 8804415 DOI: 10.1016/0014-5793(96)00845-9  0.33
1996 Ghersi-Egea JF, Gorevic PD, Ghiso J, Frangione B, Patlak CS, Fenstermacher JD. Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. Journal of Neurochemistry. 67: 880-3. PMID 8764620 DOI: 10.1046/J.1471-4159.1996.67020880.X  0.526
1996 Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid β in guinea pigs Neuroscience Letters. 206: 157-160. PMID 8710175 DOI: 10.1016/S0304-3940(96)12462-9  0.479
1996 Koudinov AR, Koudinova NV, Kumar A, Beavis RC, Ghiso J. Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins. Biochemical and Biophysical Research Communications. 223: 592-597. PMID 8687441 DOI: 10.1006/Bbrc.1996.0940  0.449
1996 Matsubara E, Soto C, Governale S, Frangione B, Ghiso J. Apolipoprotein J and Alzheimer's amyloid beta solubility. The Biochemical Journal. 316: 671-9. PMID 8687416 DOI: 10.1042/Bj3160671  0.386
1996 Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences of the United States of America. 93: 4229-34. PMID 8633046 DOI: 10.1073/Pnas.93.9.4229  0.386
1996 Baumann MH, Wisniewski T, Levy E, Plant GT, Ghiso J. C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. Biochemical and Biophysical Research Communications. 219: 238-42. PMID 8619814 DOI: 10.1006/Bbrc.1996.0211  0.524
1996 Matsubara E, Soto C, Governale S, Frangione B, Ghiso J. 724 Apollpoprotein J is associated to Alzheimer's amyioid β in biological fluids and brain lesions Neurobiology of Aging. 17: S180. DOI: 10.1016/S0197-4580(96)80726-3  0.405
1996 Ghiso J, Martel C, Mackic J, Gordon J, Comb M, Frangione B, Zlokovic B. 582 In vivo blood-brain barrier uptake of Alzheimer's Aβ peptides in guinea pigs: Evidence for vascular sequestration of Aβ1-40 (but not Aβ1-42) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80584-7  0.546
1995 Ghiso J, Plant GT, Révész T, Wisniewski T, Frangione B. Familial cerebral amyloid angiopathy (British type) with nonneuritic amyloid plaque formation may be due to a novel amyloid protein. Journal of the Neurological Sciences. 129: 74-5. PMID 7751849 DOI: 10.1016/0022-510X(94)00274-R  0.541
1995 Matsubara E, Frangione B, Ghiso J. Characterization of apolipoprotein J-Alzheimer's A beta interaction. The Journal of Biological Chemistry. 270: 7563-7. PMID 7706304 DOI: 10.1074/Jbc.270.13.7563  0.494
1995 Smith MA, Siedlak SL, Richey PL, Mulvihill P, Ghiso J, Frangione B, Tagliavini F, Giaccone G, Bugiani O, Praprotnik D. Tau protein directly interacts with the amyloid beta-protein precursor: implications for Alzheimer's disease. Nature Medicine. 1: 365-9. PMID 7585068 DOI: 10.1038/Nm0495-365  0.521
1995 Wisniewski T, Palha JA, Ghiso J, Frangione B. S182 protein in Alzheimer's disease neuritic plaques. Lancet. 346: 1366. PMID 7475795 DOI: 10.1016/S0140-6736(95)92379-9  0.418
1994 Ghiso J, Gardella JE, Liem L, Gorevic PD, Frangione B. Characterization of a novel processing pathway for Alzheimer's amyloid beta precursor protein. Neuroscience Letters. 171: 213-6. PMID 8084490 DOI: 10.1016/0304-3940(94)90642-4  0.484
1994 Ghiso J, Wisniewski T, Frangione B. Unifying features of systemic and cerebral amyloidosis. Molecular Neurobiology. 8: 49-64. PMID 7916192 DOI: 10.1007/Bf02778007  0.549
1994 Wisniewski T, Ghiso J, Frangione B. Alzheimer's disease and soluble A beta. Neurobiology of Aging. 15: 143-52. PMID 7838284 DOI: 10.1016/0197-4580(94)90105-8  0.579
1994 Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochemical and Biophysical Research Communications. 205: 1431-7. PMID 7802679 DOI: 10.1006/Bbrc.1994.2825  0.432
1994 Koudinov A, Matsubara E, Frangione B, Ghiso J. The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma. Biochemical and Biophysical Research Communications. 205: 1164-71. PMID 7802646 DOI: 10.1006/Bbrc.1994.2788  0.483
1994 Frangione B, Wisniewski T, Ghiso J. Chaperoning Alzheimer's amyloids. Neurobiology of Aging. 15: S97-9. PMID 7700474 DOI: 10.1016/0197-4580(94)90182-1  0.538
1994 Cheung TT, Ghiso J, Shojif M, Cai X, Golde T, Gandy S, Frangione B, Younkin S. Characterization by radiosequencing of the carboxyl-terminal derivatives produced from normal and mutant amyloid β protein precursors Amyloid. 1: 30-38. DOI: 10.3109/13506129409148622  0.533
1993 Wisniewski T, Golabek A, Matsubara E, Ghiso J, Frangione B. Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid. Biochemical and Biophysical Research Communications. 192: 359-65. PMID 8484748 DOI: 10.1006/Bbrc.1993.1423  0.479
1993 Gardella JE, Gorgone GA, Candela L, Ghiso J, Castaño EM, Frangione B, Gorevic PD. High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein. The Biochemical Journal. 294: 667-74. PMID 8379923 DOI: 10.1042/Bj2940667  0.357
1993 Ghiso J, Matsubara E, Koudinov A, Choi-Miura NH, Tomita M, Wisniewski T, Frangione B. The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. The Biochemical Journal. 293: 27-30. PMID 8328966 DOI: 10.1042/Bj2930027  0.466
1993 Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochemical and Biophysical Research Communications. 197: 1034-40. PMID 8280117 DOI: 10.1006/Bbrc.1993.2582  0.463
1993 Wisniewski T, Castano E, Ghiso J, Frangione B. Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro. Annals of Neurology. 34: 631-3. PMID 8215255 DOI: 10.1002/Ana.410340422  0.447
1992 Coria F, Moreno A, Torres A, Ahmad I, Ghiso J. Distribution of Alzheimer's disease amyloid protein precursor in normal human and rat nervous system. Neuropathology and Applied Neurobiology. 18: 27-35. PMID 1579198 DOI: 10.1111/J.1365-2990.1992.Tb00762.X  0.501
1992 Vidal RG, Ghiso J, Gallo G, Cohen M, Gambetti PL, Frangione B. Amyloidoma of the CNS. II. Immunohistochemical and biochemical study. Neurology. 42: 2024-8. PMID 1383872 DOI: 10.1212/Wnl.42.10.2024  0.495
1992 Ghiso J, Wisniewski T, Vidal R, Rostagno A, Frangione B. Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease. The Biochemical Journal. 282: 517-22. PMID 1372166 DOI: 10.1042/Bj2820517  0.439
1992 Ghiso J, Rostagno A, Gardella JE, Liem L, Gorevic PD, Frangione B. A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion. The Biochemical Journal. 288: 1053-9. PMID 1281980 DOI: 10.1042/Bj2881053  0.47
1991 Tagliavini F, Giaccone G, Verga L, Ghiso J, Frangione B, Bugiani O. Alzheimer patients: preamyloid deposits are immunoreactive with antibodies to extracellular domains of the amyloid precursor protein. Neuroscience Letters. 128: 117-20. PMID 1922939 DOI: 10.1016/0304-3940(91)90773-M  0.456
1991 Kuruvilla AP, Hochwald GM, Ghiso J, Castaño EM, Pizzolato M, Frangione B. Isolation and amino terminal sequence of beta-trace, a novel protein from human cerebrospinal fluid. Brain Research. 565: 337-40. PMID 1726844 DOI: 10.1016/0006-8993(91)91666-O  0.32
1991 Wisniewski T, Ghiso J, Frangione B. Peptides homologous to the amyloid protein of Alzheimer's disease containing a glutamine for glutamic acid substitution have accelerated amyloid fibril formation. Biochemical and Biophysical Research Communications. 179: 1247-54. PMID 1681804 DOI: 10.1016/0006-291X(91)91706-I  0.574
1991 Tagliavini F, Prelli F, Ghiso J, Bugiani O, Serban D, Prusiner SB, Farlow MR, Ghetti B, Frangione B. Amyloid protein of Gerstmann-Sträussler-Scheinker disease (Indiana kindred) is an 11 kd fragment of prion protein with an N-terminal glycine at codon 58. The Embo Journal. 10: 513-9. PMID 1672107 DOI: 10.1002/J.1460-2075.1991.Tb07977.X  0.499
1991 Haltia M, Ghiso J, Wisniewski T, Kiuru S, Miller D, Frangione B. Gelsolin variant and beta-amyloid co-occur in a case of Alzheimer's with Lewy bodies. Neurobiology of Aging. 12: 313-6. PMID 1660109 DOI: 10.1016/0197-4580(91)90007-7  0.466
1991 Gorevic PD, Munoz PC, Gorgone G, Purcell JJ, Rodrigues M, Ghiso J, Levy E, Haltia M, Frangione B. Amyloidosis due to a mutation of the gelsolin gene in an American family with lattice corneal dystrophy type II. The New England Journal of Medicine. 325: 1780-5. PMID 1658654 DOI: 10.1056/Nejm199112193252505  0.335
1990 Ghiso J, Saball E, Leoni J, Rostagno A, Frangione B. Binding of cystatin C to C4: the importance of sense-antisense peptides in their interaction. Proceedings of the National Academy of Sciences of the United States of America. 87: 1288-91. PMID 2304899 DOI: 10.1073/Pnas.87.4.1288  0.302
1990 Ghiso J, Haltia M, Prelli F, Novello J, Frangione B. Gelsolin variant (Asn-187) in familial amyloidosis, Finnish type. The Biochemical Journal. 272: 827-30. PMID 2176481 DOI: 10.1042/Bj2720827  0.388
1990 Levy E, Haltia M, Fernandez-Madrid I, Koivunen O, Ghiso J, Prelli F, Frangione B. Mutation in gelsolin gene in Finnish hereditary amyloidosis. The Journal of Experimental Medicine. 172: 1865-7. PMID 2175344 DOI: 10.1084/Jem.172.6.1865  0.36
1990 Haltia M, Prelli F, Ghiso J, Kiuru S, Somer H, Palo J, Frangione B. Amyloid protein in familial amyloidosis (Finnish type) is homologous to gelsolin, an actin-binding protein. Biochemical and Biophysical Research Communications. 167: 927-32. PMID 2157434 DOI: 10.1016/0006-291X(90)90612-Q  0.502
1990 Gardella JE, Ghiso J, Gorgone GA, Marratta D, Kaplan AP, Frangione B, Gorevic PD. Intact Alzheimer amyloid precursor protein (APP) is present in platelet membranes and is encoded by platelet mRNA. Biochemical and Biophysical Research Communications. 173: 1292-8. PMID 1702629 DOI: 10.1016/S0006-291X(05)80927-1  0.366
1989 Levy E, Lopez-Otin C, Ghiso J, Geltner D, Frangione B. Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases. The Journal of Experimental Medicine. 169: 1771-8. PMID 2541223 DOI: 10.1084/Jem.169.5.1771  0.361
1989 Ghiso J, Tagliavini F, Timmers WF, Frangione B. Alzheimer's disease amyloid precursor protein is present in senile plaques and cerebrospinal fluid: immunohistochemical and biochemical characterization. Biochemical and Biophysical Research Communications. 163: 430-7. PMID 2476128 DOI: 10.1016/0006-291X(89)92154-2  0.507
1986 Ghiso J, Pons-Estel B, Frangione B. Hereditary cerebral amyloid angiopathy: the amyloid fibrils contain a protein which is a variant of cystatin C, an inhibitor of lysosomal cysteine proteases. Biochemical and Biophysical Research Communications. 136: 548-54. PMID 3707586 DOI: 10.1016/0006-291X(86)90475-4  0.457
1986 Castaño EM, Ghiso J, Prelli F, Gorevic PD, Migheli A, Frangione B. In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein. Biochemical and Biophysical Research Communications. 141: 782-9. PMID 3541938 DOI: 10.1016/S0006-291X(86)80241-8  0.516
1986 Ghiso J, Jensson O, Frangione B. Amyloid fibrils in hereditary cerebral hemorrhage with amyloidosis of Icelandic type is a variant of gamma-trace basic protein (cystatin C). Proceedings of the National Academy of Sciences of the United States of America. 83: 2974-8. PMID 3517880 DOI: 10.1073/Pnas.83.9.2974  0.385
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