Lena Al-Harthi - Publications

Rush University, Chicago, IL, United States 
Virology Biology, Immunology, Neuroscience Biology

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lutgen V, Narasipura SD, Barbian HJ, Richards M, Wallace J, Razmpour R, Buzhdygan T, Ramirez SH, Prevedel L, Eugenin EA, Al-Harthi L. HIV infects astrocytes in vivo and egresses from the brain to the periphery. Plos Pathogens. 16: e1008381. PMID 32525948 DOI: 10.1371/journal.ppat.1008381  0.32
2017 Yu C, Narasipura SD, Richards MH, Hu XT, Yamamoto B, Al-Harthi L. HIV and drug abuse mediate astrocyte senescence in a β-catenin-dependent manner leading to neuronal toxicity. Aging Cell. PMID 28612507 DOI: 10.1111/acel.12593  0.32
2016 Lutgen V, Narasipura SD, Sharma A, Min S, Al-Harthi L. β-Catenin signaling positively regulates glutamate uptake and metabolism in astrocytes. Journal of Neuroinflammation. 13: 242. PMID 27612942 DOI: 10.1186/s12974-016-0691-7  0.36
2016 Kerzerho J, McIlvaine EJ, Anthony P, Mack WJ, Wang CH, Frederick T, Operskalski E, Chen Z, Al-Harthi L, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Akbari O, et al. Impact of Hepatitis C Virus on the Circulating Levels of IL-7 in HIV-1 Coinfected Women. Journal of Acquired Immune Deficiency Syndromes (1999). 71: 172-180. PMID 26761519 DOI: 10.1097/QAI.0000000000000832  0.68
2015 Richards MH, Narasipura SD, Seaton MS, Lutgen V, Al-Harthi L. Migration of CD8+ T Cells into the Central Nervous System Gives Rise to Highly Potent Anti-HIV CD4dimCD8bright T Cells in a Wnt Signaling-Dependent Manner. Journal of Immunology (Baltimore, Md. : 1950). PMID 26582945 DOI: 10.4049/jimmunol.1501394  0.32
2015 Zhang YG, Wu S, Lu R, Richards MH, Huelsmann EJ, Lacek AT, Nabatiyan A, Chen D, Al-Harthi L, Zloza A, Sun J. HIV Infection Leads to Redistribution of Leaky Claudin-2 in the Intestine of Humanized SCID IL-2R(-/-) Hu-PBMC Mice. Aids Research and Human Retroviruses. PMID 25853489 DOI: 10.1089/aid.2014.0341  0.92
2015 Richards MH, Narasipura SD, Kim S, Seaton MS, Lutgen V, Al-Harthi L. Dynamic interaction between astrocytes and infiltrating PBMCs in context of neuroAIDS. Glia. 63: 441-51. PMID 25331637 DOI: 10.1002/glia.22763  0.36
2014 Aljawai Y, Richards MH, Seaton MS, Narasipura SD, Al-Harthi L. β-Catenin/TCF-4 signaling regulates susceptibility of macrophages and resistance of monocytes to HIV-1 productive infection. Current Hiv Research. 12: 164-73. PMID 24862328 DOI: 10.2174/1570162X12666140526122249  0.36
2014 Richards MH, Seaton MS, Wallace J, Al-Harthi L. Porcupine is not required for the production of the majority of Wnts from primary human astrocytes and CD8+ T cells. Plos One. 9: e92159. PMID 24647048 DOI: 10.1371/journal.pone.0092159  0.36
2014 Lu R, Wu S, Zhang Y, Xia Y, Huelsmann EJ, Lacek AT, Nabatiyan A, Richards MH, Narasipura SD, Lutgen V, Chen H, Kaufman HL, Chen D, Al-Harthi L, Zloza A, et al. HIV infection accelerates gastrointestinal tumor outgrowth in NSG-HuPBL mice. Aids Research and Human Retroviruses. 30: 677-84. PMID 24593860 DOI: 10.1089/AID.2013.0289  0.36
2012 Henderson LJ, Sharma A, Monaco MC, Major EO, Al-Harthi L. Human immunodeficiency virus type 1 (HIV-1) transactivator of transcription through its intact core and cysteine-rich domains inhibits Wnt/β-catenin signaling in astrocytes: relevance to HIV neuropathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16306-13. PMID 23152614 DOI: 10.1523/JNEUROSCI.3145-12.2012  0.36
2012 Henderson LJ, Narasipura SD, Adarichev V, Kashanchi F, Al-Harthi L. Identification of novel T cell factor 4 (TCF-4) binding sites on the HIV long terminal repeat which associate with TCF-4, β-catenin, and SMAR1 to repress HIV transcription. Journal of Virology. 86: 9495-503. PMID 22674979 DOI: 10.1128/JVI.00486-12  0.36
2012 Zloza A, Kohlhapp FJ, Lyons GE, Schenkel JM, Moore TV, Lacek AT, O'Sullivan JA, Varanasi V, Williams JW, Jagoda MC, Bellavance EC, Marzo AL, Thomas PG, Zafirova B, Poli? B, ... Al-Harthi L, et al. NKG2D signaling on CD8⁺ T cells represses T-bet and rescues CD4-unhelped CD8⁺ T cell memory recall but not effector responses. Nature Medicine. 18: 422-8. PMID 22366950 DOI: 10.1038/nm.2683  0.36
2012 Narasipura SD, Henderson LJ, Fu SW, Chen L, Kashanchi F, Al-Harthi L. Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes. Journal of Virology. 86: 1911-21. PMID 22156527 DOI: 10.1128/JVI.06266-11  0.36
2011 Wu J, Richards MH, Huang J, Al-Harthi L, Xu X, Lin R, Xie F, Gibson AW, Edberg JC, Kimberly RP. Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions. Plos One. 6: e26143. PMID 22022540 DOI: 10.1371/journal.pone.0026143  0.36
2011 Sharma A, Hu XT, Napier TC, Al-Harthi L. Methamphetamine and HIV-1 Tat down regulate β-catenin signaling: implications for methampetamine abuse and HIV-1 co-morbidity. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 597-607. PMID 21744004 DOI: 10.1007/s11481-011-9295-2  0.36
2011 Li W, Henderson LJ, Major EO, Al-Harthi L. IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 186: 6771-8. PMID 21562161 DOI: 10.4049/jimmunol.1100099  0.36
2011 Kehn-Hall K, Guendel I, Carpio L, Skaltsounis L, Meijer L, Al-Harthi L, Steiner JP, Nath A, Kutsch O, Kashanchi F. Inhibition of Tat-mediated HIV-1 replication and neurotoxicity by novel GSK3-beta inhibitors. Virology. 415: 56-68. PMID 21514616 DOI: 10.1016/j.virol.2011.03.025  0.36
2011 Henderson LJ, Al-Harthi L. Role of β-catenin/TCF-4 signaling in HIV replication and pathogenesis: insights to informing novel anti-HIV molecular therapeutics. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 247-59. PMID 21384147 DOI: 10.1007/s11481-011-9266-7  0.36
2010 Schenkel JM, Zloza A, Li W, Narasipura SD, Al-Harthi L. Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 185: 2013-9. PMID 20631314 DOI: 10.4049/jimmunol.0902572  0.92
2010 Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. The Journal of Infectious Diseases. 201: 823-34. PMID 20151840 DOI: 10.1086/650997  0.36
2009 Zloza A, Schenkel JM, Tenorio AR, Martinson JA, Jeziorczak PM, Al-Harthi L. Potent HIV-specific responses are enriched in a unique subset of CD8+ T cells that coexpresses CD4 on its surface. Blood. 114: 3841-53. PMID 19700667 DOI: 10.1182/blood-2009-02-202481  0.92
2008 Kovacs A, Al-Harthi L, Christensen S, Mack W, Cohen M, Landay A. CD8(+) T cell activation in women coinfected with human immunodeficiency virus type 1 and hepatitis C virus. The Journal of Infectious Diseases. 197: 1402-7. PMID 18444798 DOI: 10.1086/587696  0.68
2008 Kumar A, Zloza A, Moon RT, Watts J, Tenorio AR, Al-Harthi L. Active beta-catenin signaling is an inhibitory pathway for human immunodeficiency virus replication in peripheral blood mononuclear cells. Journal of Virology. 82: 2813-20. PMID 18199649 DOI: 10.1128/JVI.02498-07  0.36
2007 Al-Harthi L, MaWhinney S, Connick E, Schooley RT, Forster JE, Benson C, Thompson M, Judson F, Palella F, Landay A. Immunophenotypic alterations in acute and early HIV infection. Clinical Immunology (Orlando, Fla.). 125: 299-308. PMID 17916441 DOI: 10.1016/j.clim.2007.08.011  0.36
2007 Martinson JA, Tenorio AR, Montoya CJ, Al-Harthi L, Gichinga CN, Krieg AM, Baum LL, Landay AL. Impact of class A, B and C CpG-oligodeoxynucleotides on in vitro activation of innate immune cells in human immunodeficiency virus-1 infected individuals. Immunology. 120: 526-35. PMID 17343615 DOI: 10.1111/j.1365-2567.2007.02530.x  0.4
2007 Bahbouhi B, Landay A, Tenorio A, Al-Harthi L. HIV infection of primary CD4+ Th2 cells, defined by expression of the chemoattractant receptor-homologous (CRTH2), induces a Th0 phenotype. Aids Research and Human Retroviruses. 23: 269-77. PMID 17331033 DOI: 10.1089/aid.2006.0151  0.68
2007 Sailer CA, Pott GB, Dinarello CA, Whinney SM, Forster JE, Larson-Duran JK, Landay A, Al-Harthi L, Schooley RT, Benson CA, Judson FN, Thompson M, Palella FJ, Shapiro L. Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon- gamma levels. The Journal of Infectious Diseases. 195: 734-8. PMID 17262717 DOI: 10.1086/511435  0.36
2006 Montoya CJ, Jie HB, Al-Harthi L, Mulder C, Patiño PJ, Rugeles MT, Krieg AM, Landay AL, Wilson SB. Activation of plasmacytoid dendritic cells with TLR9 agonists initiates invariant NKT cell-mediated cross-talk with myeloid dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 1028-39. PMID 16818759  0.36
2006 Al-Harthi L, Voris J, Du W, Wright D, Nowicki M, Frederick T, Landay A, Kovacs A. Evaluating the impact of hepatitis C virus (HCV) on highly active antiretroviral therapy-mediated immune responses in HCV/HIV-coinfected women: role of HCV on expression of primed/memory T cells. The Journal of Infectious Diseases. 193: 1202-10. PMID 16586355 DOI: 10.1086/500843  0.68
2006 Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 induces HIV replication in primary naive T cells through a nuclear factor of activated T cell (NFAT)-dependent pathway. Virology. 350: 443-52. PMID 16542695 DOI: 10.1016/j.virol.2006.02.019  0.68
2006 Zloza A, Al-Harthi L. Multiple populations of T lymphocytes are distinguished by the level of CD4 and CD8 coexpression and require individual consideration. Journal of Leukocyte Biology. 79: 4-6. PMID 16380600 DOI: 10.1189/jlb.0805455  0.92
2005 Managlia EZ, Landay A, Al-Harthi L. Interleukin-7 signalling is sufficient to phenotypically and functionally prime human CD4 naive T cells. Immunology. 114: 322-35. PMID 15720434 DOI: 10.1111/j.1365-2567.2004.02089.x  0.68
2004 Managlia EZ, Carroll D, Zloza A, Al-Harthi L. Immune modulation of HIV replication: relevance to HIV immuno- and neuro-pathogenesis. Current Hiv Research. 2: 395-401. PMID 15544459  0.92
2004 Bahbouhi B, Landay A, Al-Harthi L. Dynamics of cytokine expression in HIV productively infected primary CD4+ T cells. Blood. 103: 4581-7. PMID 14764521 DOI: 10.1182/blood-2003-12-4172  0.68
2004 Al-Harthi L, Voris J, Patterson BK, Becker S, Eron J, Smith KY, D'Amico R, Mildvan D, Snidow J, Pobiner B, Yau L, Landay A. Evaluation of the impact of highly active antiretroviral therapy on immune recovery in antiretroviral naive patients Hiv Medicine. 5: 55-65. PMID 14731171 DOI: 10.1111/j.1468-1293.2004.00186.x  0.36
2003 Jacobson JM, Lederman MM, Spritzler J, Valdez H, Tebas P, Skowron G, Wang R, Jackson JB, Fox L, Landay A, Gilbert MJ, O'Neil D, Bancroft L, Al-Harthi L, Jacobson MA, et al. Granulocyte-macrophage colony-stimulating factor induces modest increases in plasma human immunodeficiency virus (HIV) type 1 RNA levels and CD4+ lymphocyte counts in patients with uncontrolled HIV infection. The Journal of Infectious Diseases. 188: 1804-14. PMID 14673758 DOI: 10.1086/379899  0.36
2003 Poirier MC, Divi RL, Al-Harthi L, Olivero OA, Nguyen V, Walker B, Landay AL, Walker VE, Charurat M, Blattner WA. Long-term mitochondrial toxicity in HIV-uninfected infants born to HIV-infected mothers. Journal of Acquired Immune Deficiency Syndromes (1999). 33: 175-83. PMID 12794551  0.36
2003 Zloza A, Sullivan YB, Connick E, Landay AL, Al-Harthi L. CD8+ T cells that express CD4 on their surface (CD4dimCD8bright T cells) recognize an antigen-specific target, are detected in vivo, and can be productively infected by T-tropic HIV. Blood. 102: 2156-64. PMID 12791668 DOI: 10.1182/blood-2002-07-1972  0.92
2003 Fleuridor R, Wilson B, Hou R, Landay A, Kessler H, Al-Harthi L. CD1d-restricted natural killer T cells are potent targets for human immunodeficiency virus infection. Immunology. 108: 3-9. PMID 12519296  0.68
2002 Al-Harthi L, Landay A. Immune recovery in HIV disease: role of the thymus and T cell expansion in immune reconstitution strategies. Journal of Hematotherapy & Stem Cell Research. 11: 777-86. PMID 12427284 DOI: 10.1089/152581602760404586  0.68
2002 Nokta MA, Li XD, Al-Harthi L, Nichols J, Pou A, Asmuth D, Landay A, Pollard RB. Entrapment of recent thymic emigrants in lymphoid tissues from HIV-infected patients: association with HIV cellular viral load. Aids (London, England). 16: 2119-27. PMID 12409732  0.68
2002 Smith KY, Steffens CM, Truckenbrod A, Landay A, Al-Harthi L. Immune reconstitution after successful treatment with protease inhibitor-based and protease inhibitor-sparing antiretroviral regimens. Journal of Acquired Immune Deficiency Syndromes (1999). 29: 544-5. PMID 11981373  0.36
2002 Steffens CM, Managlia EZ, Landay A, Al-Harthi L. Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1. Blood. 99: 3310-8. PMID 11964298 DOI: 10.1182/blood.V99.9.3310  0.36
2002 Al-Harthi L, Guilbert LJ, Hoxie JA, Landay A. Trophoblasts are productively infected by CD4-independent isolate of HIV type 1. Aids Research and Human Retroviruses. 18: 13-7. PMID 11804552 DOI: 10.1089/088922202753394673  0.36
2001 Steffens CM, Smith KY, Landay A, Shott S, Truckenbrod A, Russert M, Al-Harthi L. T cell receptor excision circle (TREC) content following maximum HIV suppression is equivalent in HIV-infected and HIV-uninfected individuals. Aids (London, England). 15: 1757-64. PMID 11579236 DOI: 10.1097/00002030-200109280-00003  0.36
2001 Al-Harthi L, Kovacs A, Coombs RW, Reichelderfer PS, Wright DJ, Cohen MH, Cohn J, Cu-Uvin S, Watts H, Lewis S, Beckner S, Landay A. A menstrual cycle pattern for cytokine levels exists in HIV-positive women: implication for HIV vaginal and plasma shedding. Aids (London, England). 15: 1535-43. PMID 11504986 DOI: 10.1097/00002030-200108170-00011  0.68
2001 Sullivan YB, Landay AL, Zack JA, Kitchen SG, Al-Harthi L. Upregulation of CD4 on CD8+ T cells: CD4dimCD8bright T cells constitute an activated phenotype of CD8+ T cells. Immunology. 103: 270-80. PMID 11454056 DOI: 10.1046/j.1365-2567.2001.01243.x  0.36
2000 Steffens CM, Al-Harthi L, Shott S, Yogev R, Landay A. Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naïve phenotypes. Clinical Immunology (Orlando, Fla.). 97: 95-101. PMID 11027449 DOI: 10.1006/clim.2000.4938  0.36
2000 Al-Harthi L, Marchetti G, Steffens CM, Poulin J, Sékaly R, Landay A. Detection of T cell receptor circles (TRECs) as biomarkers for de novo T cell synthesis using a quantitative polymerase chain reaction-enzyme linked immunosorbent assay (PCR-ELISA). Journal of Immunological Methods. 237: 187-97. PMID 10725462 DOI: 10.1016/S0022-1759(00)00136-8  0.36
1999 Al-Harthi L, Roebuck KA, Olinger GG, Landay A, Sha BE, Hashemi FB, Spear GT. Bacterial vaginosis-associated microflora isolated from the female genital tract activates HIV-1 expression. Journal of Acquired Immune Deficiency Syndromes (1999). 21: 194-202. PMID 10421242  0.36
1998 Al-Harthi L, Roebuck KA. Human immunodeficiency virus type-1 transcription: role of the 5'-untranslated leader region (review) International Journal of Molecular Medicine. 1: 875-881. PMID 9852310  0.36
1998 Rabbi MF, Finnegan A, Al-Harthi L, Song S, Roebuck KA. Interleukin-10 enhances tumor necrosis factor-alpha activation of HIV-1 transcription in latently infected T cells. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association. 19: 321-31. PMID 9833740 DOI: 10.1097/00042560-199812010-00002  0.36
1998 Al-Harthi L, Spear GT, Hashemi FB, Landay A, Sha BE, Roebuck KA. A human immunodeficiency virus (HIV)-inducing factor from the female genital tract activates HIV-1 gene expression through the κB enhancer Journal of Infectious Diseases. 178: 1343-1351. PMID 9780254 DOI: 10.1086/314444  0.36
1998 Rabbi MF, al-Harthi L, Saifuddin M, Roebuck KA. The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage. Virology. 245: 257-69. PMID 9636365 DOI: 10.1006/viro.1998.9158  0.36
1998 Al-Harthi L, Roebuck KA, Landay A. Induction of HIV-1 replication by type 1-like cytokines, interleukin (IL)-12 and IL-15: Effect on viral transcriptional activation, cellular proliferation, and endogenous cytokine production Journal of Clinical Immunology. 18: 124-131. PMID 9533656 DOI: 10.1023/A:1023246800353  0.36
1997 Al-Harthi L, Roebuck KA, Kessler H, Landay A. Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor Journal of Infectious Diseases. 176: 1175-1179. PMID 9359716  0.36
1997 Rabbi MF, Al-Harthi L, Roebuck KA. TNFalpha cooperates with the protein kinase A pathway to synergistically increase HIV-1 LTR transcription via downstream TRE-like cAMP response elements. Virology. 237: 422-9. PMID 9356353 DOI: 10.1006/viro.1997.8798  0.36
1997 Spear GT, Al-Harthi L, Sha B, Saarloos MN, Hayden M, Massad LS, Benson C, Roebuck KA, Glick NR, Landay A. A potent activator of HIV-1 replication is present in the genital tract of a subset of HIV-1-infected and uninfected women Aids. 11: 1319-1326. PMID 9302440 DOI: 10.1097/00002030-199711000-00005  0.36
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