| Year |
Citation |
Score |
| 2023 |
Tang Q, Sinclair M, Hasdemir HS, Stein RA, Karakas E, Tajkhorshid E, Mchaourab HS. Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nature Communications. 14: 7184. PMID 37938578 DOI: 10.1038/s41467-023-42937-5 |
0.395 |
|
| 2023 |
Tang Q, Sinclair M, Hasdemir H, Stein R, Karakas E, Tajkhorshid E, Mchaourab H. Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Biorxiv : the Preprint Server For Biology. PMID 37398337 DOI: 10.1101/2023.05.29.541986 |
0.397 |
|
| 2022 |
Del Alamo D, DeSousa L, Nair RM, Rahman S, Meiler J, Mchaourab HS. Integrated AlphaFold2 and DEER investigation of the conformational dynamics of a pH-dependent APC antiporter. Proceedings of the National Academy of Sciences of the United States of America. 119: e2206129119. PMID 35969794 DOI: 10.1073/pnas.2206129119 |
0.369 |
|
| 2022 |
Del Alamo D, Meiler J, Mchaourab HS. Principles of Alternating Access in LeuT-fold Transporters: Commonalities and Divergences. Journal of Molecular Biology. 434: 167746. PMID 35843285 DOI: 10.1016/j.jmb.2022.167746 |
0.327 |
|
| 2022 |
Del Alamo D, Sala D, Mchaourab HS, Meiler J. Sampling alternative conformational states of transporters and receptors with AlphaFold2. Elife. 11. PMID 35238773 DOI: 10.7554/eLife.75751 |
0.328 |
|
| 2021 |
Thaker TM, Mishra S, Zhou W, Mohan M, Tang Q, Faraldo-Goméz JD, Mchaourab HS, Tomasiak TM. Asymmetric drug binding in an ATP-loaded inward-facing state of an ABC transporter. Nature Chemical Biology. PMID 34931066 DOI: 10.1038/s41589-021-00936-x |
0.358 |
|
| 2021 |
Hustedt EJ, Stein RA, Mchaourab HS. Protein functional dynamics from the rigorous global analysis of DEER data: Conditions, components, and conformations. The Journal of General Physiology. 153. PMID 34529007 DOI: 10.1085/jgp.201711954 |
0.362 |
|
| 2021 |
Del Alamo D, Jagessar KL, Meiler J, Mchaourab HS. Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints. Plos Computational Biology. 17: e1009107. PMID 34133419 DOI: 10.1371/journal.pcbi.1009107 |
0.354 |
|
| 2021 |
Del Alamo D, Govaerts C, Mchaourab HS. AlphaFold2 predicts the inward-facing conformation of the multidrug transporter LmrP. Proteins. PMID 33973689 DOI: 10.1002/prot.26138 |
0.348 |
|
| 2021 |
Castellano S, Claxton DP, Ficici E, Kusakizako T, Stix R, Zhou W, Nureki O, Mchaourab HS, Faraldo-Gómez JD. Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na in ion-coupled drug efflux. The Journal of Biological Chemistry. 296: 100262. PMID 33837745 DOI: 10.1016/j.jbc.2021.100262 |
0.344 |
|
| 2021 |
Castellano S, Claxton DP, Ficici E, Kusakizako T, Stix R, Zhou W, Nureki O, Mchaourab HS, Faraldo-Gómez JD. Conserved binding site in the N-lobe of prokaryotic MATE transporters suggests a role for Na in ion-coupled drug efflux. The Journal of Biological Chemistry. PMID 33402425 DOI: 10.1074/jbc.RA120.016792 |
0.348 |
|
| 2020 |
Yardeni EH, Mishra S, Stein RA, Bibi E, Mchaourab HS. The multidrug transporter MdfA deviates from the canonical model of alternating access of MFS Transporters. Journal of Molecular Biology. PMID 32860775 DOI: 10.1016/J.Jmb.2020.08.017 |
0.481 |
|
| 2020 |
Rahman S, Mchaourab HS. ATP-dependent interactions of a cargo protein with the transmembrane domain of a polypeptide processing and secretion ABC transporter. The Journal of Biological Chemistry. PMID 32820049 DOI: 10.1074/Jbc.Ra120.014934 |
0.44 |
|
| 2020 |
Debruycker V, Hutchin A, Masureel M, Ficici E, Martens C, Legrand P, Stein RA, Mchaourab HS, Faraldo-Gómez JD, Remaut H, Govaerts C. An embedded lipid in the multidrug transporter LmrP suggests a mechanism for polyspecificity. Nature Structural & Molecular Biology. PMID 32719456 DOI: 10.1038/S41594-020-0464-Y |
0.444 |
|
| 2020 |
Chavan TS, Cheng RC, Jiang T, Mathews II, Stein RA, Koehl A, Mchaourab HS, Tajkhorshid E, Maduke M. A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the Cl/H transport cycle. Elife. 9. PMID 32310757 DOI: 10.7554/Elife.53479 |
0.448 |
|
| 2020 |
Yang Z, Stein RA, Ngendahimana T, Pink M, Rajca S, Jeschke G, Eaton SS, Eaton GR, Mchaourab HS, Rajca A. Supramolecular Approach to Electron Paramagnetic Resonance Distance Measurement of Spin-Labeled Proteins. The Journal of Physical Chemistry. B. PMID 32227839 DOI: 10.1021/Acs.Jpcb.0C00743 |
0.397 |
|
| 2020 |
Jagessar KL, Claxton DP, Stein RA, Mchaourab HS. Sequence and structural determinants of ligand-dependent alternating access of a MATE transporter. Proceedings of the National Academy of Sciences of the United States of America. PMID 32075917 DOI: 10.1073/Pnas.1917139117 |
0.487 |
|
| 2020 |
Chavan TS, Cheng RC, Jiang T, Mathews II, Stein RA, Koehl A, Mchaourab HS, Tajkhorshid E, Maduke M. Author response: A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle Elife. DOI: 10.7554/Elife.53479.Sa2 |
0.353 |
|
| 2020 |
Chavan T, Cheng R, Jiang T, Mathews II, Stein RA, Koehl A, Krishnamoorti A, Durham RJ, Berka V, Mchaourab H, Tajkhorshid E, Jayaraman V, Maduke M. Investigating Conformational Changes to Understand the Transport Mechanism of CLC Chloride/Proton Antiporters Biophysical Journal. 118: 443a. DOI: 10.1016/J.Bpj.2019.11.2481 |
0.382 |
|
| 2019 |
Del Alamo D, Tessmer MH, Stein RA, Feix JB, Mchaourab HS, Meiler J. Rapid Simulation of Unprocessed DEER Decay Data for Protein Fold Prediction. Biophysical Journal. PMID 31892409 DOI: 10.1016/J.Bpj.2019.12.011 |
0.397 |
|
| 2019 |
Yardeni EH, Bahrenberg T, Stein RA, Mishra S, Zomot E, Graham B, Tuck KL, Huber T, Bibi E, Mchaourab HS, Goldfarb D. Probing the solution structure of the E. coli multidrug transporter MdfA using DEER distance measurements with nitroxide and Gd(III) spin labels. Scientific Reports. 9: 12528. PMID 31467343 DOI: 10.1038/S41598-019-48694-0 |
0.484 |
|
| 2019 |
Jagessar KL, Mchaourab HS, Claxton DP. The N-terminal domain of an archaeal multidrug and toxin extrusion (MATE) transporter mediates proton coupling required for prokaryotic drug resistance. The Journal of Biological Chemistry. PMID 31289123 DOI: 10.1074/Jbc.Ra119.009195 |
0.436 |
|
| 2019 |
Dastvan R, Mishra S, Peskova YB, Nakamoto RK, Mchaourab HS. Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors. Science (New York, N.Y.). 364: 689-692. PMID 31097669 DOI: 10.1126/Science.Aav9406 |
0.426 |
|
| 2019 |
Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, ... ... Mchaourab HS, et al. Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in . Proceedings of the National Academy of Sciences of the United States of America. PMID 30755521 DOI: 10.1073/Pnas.1816247116 |
0.345 |
|
| 2018 |
Wu SY, Zou P, Mishra S, Mchaourab HS. Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants. Plos One. 13: e0207540. PMID 30475834 DOI: 10.1371/Journal.Pone.0207540 |
0.345 |
|
| 2018 |
Kusakizako T, Claxton DP, Tanaka Y, Maturana AD, Kuroda T, Ishitani R, Mchaourab HS, Nureki O. Structural Basis of H-Dependent Conformational Change in a Bacterial MATE Transporter. Structure (London, England : 1993). PMID 30449688 DOI: 10.2210/Pdb6Idp/Pdb |
0.414 |
|
| 2018 |
Warren GM, Stein RA, Mchaourab HS, Eichman BF. Movement of the RecG Motor Domain upon DNA Binding Is Required for Efficient Fork Reversal. International Journal of Molecular Sciences. 19. PMID 30301235 DOI: 10.3390/Ijms19103049 |
0.378 |
|
| 2018 |
Hustedt EJ, Marinelli F, Stein RA, Faraldo-Gómez JD, Mchaourab HS. Confidence Analysis of DEER Data and Its Structural Interpretation with Ensemble-Biased Metadynamics. Biophysical Journal. PMID 30197182 DOI: 10.1016/J.Bpj.2018.08.008 |
0.336 |
|
| 2018 |
Mishra S, Chandler SA, Williams D, Claxton DP, Koteiche HA, Stewart PL, Benesch JLP, Mchaourab HS. Engineering of a Polydisperse Small Heat-Shock Protein Reveals Conserved Motifs of Oligomer Plasticity. Structure (London, England : 1993). PMID 29983375 DOI: 10.1016/J.Str.2018.05.015 |
0.371 |
|
| 2018 |
Claxton DP, Jagessar KL, Steed PR, Stein RA, Mchaourab HS. Sodium and proton coupling in the conformational cycle of a MATE antiporter from . Proceedings of the National Academy of Sciences of the United States of America. PMID 29915043 DOI: 10.1073/Pnas.1802417115 |
0.777 |
|
| 2018 |
Paz A, Claxton DP, Kumar JP, Kazmier K, Bisignano P, Sharma S, Nolte SA, Liwag TM, Nayak V, Wright EM, Grabe M, Mchaourab HS, Abramson J. Conformational transitions of the sodium-dependent sugar transporter, vSGLT. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507231 DOI: 10.1073/Pnas.1718451115 |
0.47 |
|
| 2018 |
Raeisi Najafi A, Dastvan R, Mchaourab HS, Tajkhorshid E. Study of Conformational Transition of a Protein Secretion ABC Transporter using Molecular Dynamic Biophysical Journal. 114: 148a-149a. DOI: 10.1016/J.Bpj.2017.11.833 |
0.392 |
|
| 2017 |
Collauto A, Mishra S, Litvinov A, Mchaourab HS, Goldfarb D. Direct Spectroscopic Detection of ATP Turnover Reveals Mechanistic Divergence of ABC Exporters. Structure (London, England : 1993). PMID 28712805 DOI: 10.1016/J.Str.2017.06.014 |
0.413 |
|
| 2017 |
Carra S, Alberti S, Arrigo PA, Benesch JL, Benjamin IJ, Boelens W, Bartelt-Kirbach B, Brundel BJ, Buchner J, Bukau B, Carver JA, Ecroyd H, Emanuelsson C, Finet S, Golenhofen N, ... ... Mchaourab HS, et al. The growing world of small heat shock proteins: from structure to functions. Cell Stress & Chaperones. PMID 28364346 DOI: 10.1007/S12192-017-0787-8 |
0.32 |
|
| 2017 |
Verhalen B, Dastvan R, Thangapandian S, Peskova Y, Koteiche HA, Nakamoto RK, Tajkhorshid E, Mchaourab HS. Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein. Nature. PMID 28289287 DOI: 10.1038/Nature21414 |
0.479 |
|
| 2017 |
Mchaourab HS. Principles of Energy Transduction and Alternating Access of ABC Exporters Biophysical Journal. 112: 308a. DOI: 10.1016/J.Bpj.2016.11.1665 |
0.491 |
|
| 2016 |
Kazmier K, Claxton DP, Mchaourab HS. Alternating access mechanisms of LeuT-fold transporters: trailblazing towards the promised energy landscapes. Current Opinion in Structural Biology. 45: 100-108. PMID 28040635 DOI: 10.1016/J.Sbi.2016.12.006 |
0.416 |
|
| 2016 |
Martens C, Stein RA, Masureel M, Roth A, Mishra S, Dawaliby R, Konijnenberg A, Sobott F, Govaerts C, Mchaourab HS. Lipids modulate the conformational dynamics of a secondary multidrug transporter. Nature Structural & Molecular Biology. PMID 27399258 DOI: 10.1038/Nsmb.3262 |
0.43 |
|
| 2016 |
Zhu S, Stein RA, Yoshioka C, Lee CH, Goehring A, Mchaourab HS, Gouaux E. Mechanism of NMDA Receptor Inhibition and Activation. Cell. PMID 27062927 DOI: 10.1016/J.Cell.2016.03.028 |
0.333 |
|
| 2016 |
Khantwal CM, Abraham SJ, Han W, Jiang T, Chavan TS, Cheng RC, Elvington SM, Liu CW, Mathews II, Stein RA, Mchaourab HS, Tajkhorshid E, Maduke M. Revealing an outward-facing open conformational state in a CLC Cl(-)/H(+) exchange transporter. Elife. 5. PMID 26799336 DOI: 10.7554/Elife.11189 |
0.449 |
|
| 2016 |
Dastvan R, Fischer AW, Mishra S, Meiler J, Mchaourab HS. Protonation-dependent conformational dynamics of the multidrug transporter EmrE. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787875 DOI: 10.1073/Pnas.1520431113 |
0.523 |
|
| 2016 |
Khantwal CM, Abraham SJ, Han W, Jiang T, Chavan TS, Cheng RC, Elvington SM, Liu CW, Mathews II, Stein RA, Mchaourab HS, Tajkhorshid E, Maduke M. Author response: Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter Elife. DOI: 10.7554/Elife.11189.031 |
0.354 |
|
| 2016 |
Abraham SJ, Chavan T, Cheng RC, Fenollar-Ferrer C, Han W, Islam SM, Jiang T, Khantwal CM, Mathews II, Stein RA, Roux B, Forrest LR, Mchaourab HS, Tajkhorshid E, Maduke M. An Outward-Facing Open Conformational State in a CLC Transporter Biophysical Journal. 110: 178a. DOI: 10.1016/J.Bpj.2015.11.994 |
0.483 |
|
| 2016 |
Dastvan R, Fischer AW, Mishra S, Meiler J, Mchaourab HS. Structural Dynamics of the Small Multidrug Transporter EMRE Biophysical Journal. 110: 135a. DOI: 10.1016/J.Bpj.2015.11.775 |
0.51 |
|
| 2016 |
Islam SM, Florin G, Qi Y, Shen R, Han W, Stein RA, Schulten K, Mchaourab HS, Im W, Roux B. Structural-Function Study of Membrane Proteins with Restrained-Ensemble and Dummy Spin-Label Molecular Dynamics Simulations Biophysical Journal. 110: 644a. DOI: 10.1016/J.Bpj.2015.11.3446 |
0.447 |
|
| 2016 |
Paz A, Claxton DP, Sharma S, Kazmier K, Prakash Kumar J, Nolte SA, Liwag TM, Mchaourab HS, Abramson J. Revealing the Transport Cycle Dynamics of the Sodium Dependent Sugar Transporter by Double Electron-Electron Resonance and Wide-Angle X-ray Scattering Biophysical Journal. 110: 222a. DOI: 10.1016/J.Bpj.2015.11.1228 |
0.419 |
|
| 2015 |
Krug U, Alexander NS, Stein RA, Keim A, Mchaourab HS, Sträter N, Meiler J. Characterization of the Domain Orientations of E. coli 5'-Nucleotidase by Fitting an Ensemble of Conformers to DEER Distance Distributions. Structure (London, England : 1993). PMID 26724996 DOI: 10.1016/J.Str.2015.11.007 |
0.453 |
|
| 2015 |
Claxton DP, Kazmier K, Mishra S, Mchaourab HS. Navigating Membrane Protein Structure, Dynamics, and Energy Landscapes Using Spin Labeling and EPR Spectroscopy. Methods in Enzymology. 564: 349-87. PMID 26477257 DOI: 10.1016/Bs.Mie.2015.07.026 |
0.447 |
|
| 2015 |
Schmandt N, Velisetty P, Chalamalasetti SV, Stein RA, Bonner R, Talley L, Parker MD, Mchaourab HS, Yee VC, Lodowski DT, Chakrapani S. A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation. The Journal of General Physiology. 146: 323-40. PMID 26415570 DOI: 10.1085/Jgp.201511478 |
0.36 |
|
| 2015 |
Koteiche HA, Claxton DP, Mishra S, Stein RA, McDonald ET, Mchaourab HS. Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αA(ins)-Crystallin Encode Activated Chaperones. Biochemistry. 54: 5949-58. PMID 26378715 DOI: 10.1021/Acs.Biochem.5B00678 |
0.384 |
|
| 2015 |
Kaur H, Lakatos A, Spadaccini R, Vogel R, Hoffmann C, Becker-Baldus J, Ouari O, Tordo P, Mchaourab H, Glaubitz C. The ABC exporter MsbA probed by solid state NMR - challenges and opportunities. Biological Chemistry. PMID 25849794 DOI: 10.1515/Hsz-2015-0119 |
0.466 |
|
| 2015 |
Meyer V, Swanson MA, Clouston LJ, Boraty?ski PJ, Stein RA, Mchaourab HS, Rajca A, Eaton SS, Eaton GR. Room-temperature distance measurements of immobilized spin-labeled protein by DEER/PELDOR. Biophysical Journal. 108: 1213-9. PMID 25762332 DOI: 10.1016/J.Bpj.2015.01.015 |
0.371 |
|
| 2015 |
Kazmier K, Sharma S, Islam SM, Roux B, Mchaourab HS. Ligand-Dependent Conformational Cycle of the Na+/Hydantoin Transporter Mhp1 Biophysical Journal. 108: 28a-29a. DOI: 10.1016/J.Bpj.2014.11.181 |
0.53 |
|
| 2014 |
Kazmier K, Sharma S, Islam SM, Roux B, Mchaourab HS. Conformational cycle and ion-coupling mechanism of the Na+/hydantoin transporter Mhp1. Proceedings of the National Academy of Sciences of the United States of America. 111: 14752-7. PMID 25267652 DOI: 10.1073/Pnas.1410431111 |
0.46 |
|
| 2014 |
Yu Z, Quine RW, Rinard GA, Tseitlin M, Elajaili H, Kathirvelu V, Clouston LJ, Boraty?ski PJ, Rajca A, Stein R, Mchaourab H, Eaton SS, Eaton GR. Rapid-scan EPR of immobilized nitroxides. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 247: 67-71. PMID 25240151 DOI: 10.1016/J.Jmr.2014.08.008 |
0.31 |
|
| 2014 |
Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E. Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states. Cell. 158: 778-92. PMID 25109876 DOI: 10.1016/J.Cell.2014.07.023 |
0.387 |
|
| 2014 |
Mishra S, Verhalen B, Stein RA, Wen PC, Tajkhorshid E, Mchaourab HS. Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter. Elife. 3: e02740. PMID 24837547 DOI: 10.7554/Elife.02740 |
0.525 |
|
| 2014 |
Kazmier K, Sharma S, Quick M, Islam SM, Roux B, Weinstein H, Javitch JA, McHaourab HS. Conformational dynamics of ligand-dependent alternating access in LeuT. Nature Structural & Molecular Biology. 21: 472-9. PMID 24747939 DOI: 10.1038/Nsmb.2816 |
0.51 |
|
| 2014 |
Masureel M, Martens C, Stein RA, Mishra S, Ruysschaert JM, Mchaourab HS, Govaerts C. Protonation drives the conformational switch in the multidrug transporter LmrP. Nature Chemical Biology. 10: 149-55. PMID 24316739 DOI: 10.1038/Nchembio.1408 |
0.449 |
|
| 2014 |
Cheng RC, Chang P, Fenollar-Ferrer C, Stein RA, Trone K, Forrest LR, Mchaourab HS, Maduke MC. Monitoring Substrate-Driven Structural Changes in a CLC Chloride-Proton Antiporter with Double Electron-Electron Resonance Spectroscopy Biophysical Journal. 106: 145a. DOI: 10.1016/J.Bpj.2013.11.839 |
0.5 |
|
| 2014 |
Mchaourab HS. Mapping Transporter Conformational Dynamics using Double Electron Electron Spectroscopy (DEER) Biophysical Journal. 106: 456a. DOI: 10.1016/J.Bpj.2013.11.2586 |
0.512 |
|
| 2013 |
Steed PR, Zou P, Trone KE, Mchaourab HS. Structure and pH-induced structural rearrangements of the putative multidrug efflux pump EmrD in liposomes probed by site-directed spin labeling. Biochemistry. 52: 7964-74. PMID 24148002 DOI: 10.1021/Bi4012385 |
0.769 |
|
| 2013 |
Alexander NS, Stein RA, Koteiche HA, Kaufmann KW, McHaourab HS, Meiler J. RosettaEPR: rotamer library for spin label structure and dynamics. Plos One. 8: e72851. PMID 24039810 DOI: 10.1371/Journal.Pone.0072851 |
0.436 |
|
| 2013 |
Steed PR, Stein RA, Mishra S, Goodman MC, McHaourab HS. Naâº-substrate coupling in the multidrug antiporter norm probed with a spin-labeled substrate. Biochemistry. 52: 5790-9. PMID 23902581 DOI: 10.1021/Bi4008935 |
0.766 |
|
| 2013 |
Wen PC, Verhalen B, Wilkens S, Mchaourab HS, Tajkhorshid E. On the origin of large flexibility of P-glycoprotein in the inward-facing state. The Journal of Biological Chemistry. 288: 19211-20. PMID 23658020 DOI: 10.1074/Jbc.M113.450114 |
0.516 |
|
| 2013 |
Islam SM, Stein RA, McHaourab HS, Roux B. Structural refinement from restrained-ensemble simulations based on EPR/DEER data: application to T4 lysozyme. The Journal of Physical Chemistry. B. 117: 4740-54. PMID 23510103 DOI: 10.1021/Jp311723A |
0.417 |
|
| 2013 |
Shi J, Koteiche HA, McDonald ET, Fox TL, Stewart PL, McHaourab HS. Cryoelectron microscopy analysis of small heat shock protein 16.5 (Hsp16.5) complexes with T4 lysozyme reveals the structural basis of multimode binding. The Journal of Biological Chemistry. 288: 4819-30. PMID 23277356 DOI: 10.1074/Jbc.M112.388132 |
0.39 |
|
| 2013 |
Islam SM, Stein R, Mchaourab H, Roux B. Rotamer Library of Spin Labeled Cysteines Attached to T4 Lysozyme Deduced from Molecular Dynamics Simulations Constrained by Double Electron-Electron Resonance (Deer) Experiments Biophysical Journal. 104: 335a. DOI: 10.1016/J.Bpj.2012.11.1862 |
0.416 |
|
| 2012 |
Yirdaw RB, McHaourab HS. Direct observation of T4 lysozyme hinge-bending motion by fluorescence correlation spectroscopy. Biophysical Journal. 103: 1525-36. PMID 23062345 DOI: 10.1016/J.Bpj.2012.07.053 |
0.744 |
|
| 2012 |
McHaourab HS, Lin YL, Spiller BW. Crystal structure of an activated variant of small heat shock protein Hsp16.5. Biochemistry. 51: 5105-12. PMID 22670769 DOI: 10.1021/Bi300525X |
0.408 |
|
| 2012 |
Mishra S, Stein RA, McHaourab HS. Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins. Febs Letters. 586: 330-6. PMID 22289178 DOI: 10.1016/J.Febslet.2012.01.019 |
0.325 |
|
| 2012 |
McDonald ET, Bortolus M, Koteiche HA, Mchaourab HS. Sequence, structure, and dynamic determinants of Hsp27 (HspB1) equilibrium dissociation are encoded by the N-terminal domain. Biochemistry. 51: 1257-68. PMID 22264079 DOI: 10.1021/Bi2017624 |
0.459 |
|
| 2012 |
Steed R, Trone K, Mchaourab H. Substrate Binding and Transport by a Bacterial Multidrug MFS Transporter Biophysical Journal. 102: 714a. DOI: 10.1016/J.Bpj.2011.11.3873 |
0.424 |
|
| 2012 |
Zou P, Mchaourab H. Structure and Dynamics of the MFS Multidrug Transporter EmrD Biophysical Journal. 102: 660a. DOI: 10.1016/J.Bpj.2011.11.3594 |
0.528 |
|
| 2012 |
Masureel M, Smriti S, Martens C, Zou P, Ruysschaert J, Mchaourab HS, Govaerts C. Studying the Conformational Cycle of the Secondary Multidrug Transporter LmrP by EPR Spectroscopy Biophysical Journal. 102: 660a. DOI: 10.1016/J.Bpj.2011.11.3593 |
0.499 |
|
| 2012 |
Sharma S, Stein RA, Quick M, Stolzenberg S, Shi L, Weinstein H, Javitch JA, Mchaourab HS. Conformational Dynamics in the Transport Cycle of Leucine Transporter on the Extracellular-Side Biophysical Journal. 102: 606a. DOI: 10.1016/J.Bpj.2011.11.3304 |
0.51 |
|
| 2012 |
Kazmier K, Quick M, Shi L, Weinstein H, Javitch JA, Mchaourab HS. Structure, Dynamics, and Mechanism of the Leucine Transporter Studied by Double Electron Electron Resonance Spectroscopy Biophysical Journal. 102: 606a. DOI: 10.1016/J.Bpj.2011.11.3303 |
0.454 |
|
| 2011 |
McHaourab HS, Steed PR, Kazmier K. Toward the fourth dimension of membrane protein structure: insight into dynamics from spin-labeling EPR spectroscopy. Structure (London, England : 1993). 19: 1549-61. PMID 22078555 DOI: 10.1016/J.Str.2011.10.009 |
0.758 |
|
| 2011 |
Mushrush DJ, Koteiche HA, Sammons MA, Link AJ, McHaourab HS, Lacy DB. Studies of the mechanistic details of the pH-dependent association of botulinum neurotoxin with membranes. The Journal of Biological Chemistry. 286: 27011-8. PMID 21652698 DOI: 10.1074/Jbc.M111.256982 |
0.39 |
|
| 2011 |
Hoffman L, Stein RA, Colbran RJ, Mchaourab HS. Conformational changes underlying calcium/calmodulin-dependent protein kinase II activation. The Embo Journal. 30: 1251-62. PMID 21343908 DOI: 10.1038/Emboj.2011.40 |
0.4 |
|
| 2011 |
Kazmier K, Alexander NS, Meiler J, McHaourab HS. Algorithm for selection of optimized EPR distance restraints for de novo protein structure determination. Journal of Structural Biology. 173: 549-57. PMID 21074624 DOI: 10.1016/J.Jsb.2010.11.003 |
0.41 |
|
| 2011 |
Hirst SJ, Alexander N, McHaourab HS, Meiler J. RosettaEPR: an integrated tool for protein structure determination from sparse EPR data. Journal of Structural Biology. 173: 506-14. PMID 21029778 DOI: 10.1016/J.Bpj.2010.12.1390 |
0.411 |
|
| 2010 |
Qin X, Byrne M, Mori T, Zou P, Williams DR, McHaourab H, Johnson CH. Intermolecular associations determine the dynamics of the circadian KaiABC oscillator. Proceedings of the National Academy of Sciences of the United States of America. 107: 14805-10. PMID 20679240 DOI: 10.1073/Pnas.1002119107 |
0.328 |
|
| 2010 |
Claxton DP, Quick M, Shi L, de Carvalho FD, Weinstein H, Javitch JA, McHaourab HS. Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters. Nature Structural & Molecular Biology. 17: 822-9. PMID 20562855 DOI: 10.1038/Nsmb.1854 |
0.509 |
|
| 2010 |
Amadi ST, Koteiche HA, Mishra S, McHaourab HS. Structure, dynamics, and substrate-induced conformational changes of the multidrug transporter EmrE in liposomes. The Journal of Biological Chemistry. 285: 26710-8. PMID 20551331 DOI: 10.1074/Jbc.M110.132621 |
0.551 |
|
| 2010 |
Zou P, McHaourab HS. Increased sensitivity and extended range of distance measurements in spin-labeled membrane proteins: Q-band double electron-electron resonance and nanoscale bilayers. Biophysical Journal. 98: L18-20. PMID 20303847 DOI: 10.1016/J.Bpj.2009.12.4193 |
0.407 |
|
| 2010 |
Gustot A, Ruysschaert JM, McHaourab H, Govaerts C. Lipid composition regulates the orientation of transmembrane helices in HorA, an ABC multidrug transporter. The Journal of Biological Chemistry. 285: 14144-51. PMID 20223819 DOI: 10.1074/Jbc.M109.079673 |
0.426 |
|
| 2010 |
Hoffman L, Kaufmann K, Colbran R, Meiler J, Mchaourab H. Conformational Changes of CaMKII: A Model of Activation Biophysical Journal. 98: 675a. DOI: 10.1016/J.Bpj.2009.12.3710 |
0.407 |
|
| 2010 |
Kazmier K, Alexander NS, Meiler J, Mchaourab HS. Optimal Selection of EPR Distance Restraints for Global Folding of Protein Structure Biophysical Journal. 98: 571a-572a. DOI: 10.1016/J.Bpj.2009.12.3104 |
0.401 |
|
| 2010 |
Hirst S, Alexander N, Kaufmann K, Mchaourab H, Meiler J. Rosettaepr: Developing Protein Structure Prediction Methods using Sparse SDSL-EPR Data Biophysical Journal. 98: 461a-462a. DOI: 10.1016/J.Bpj.2009.12.2508 |
0.436 |
|
| 2010 |
Mchaourab HS, Zou P. Increased Sensitivity and Range of Distance Measurements in Spin Labeled Membrane Proteins Biophysical Journal. 98: 399a. DOI: 10.1016/J.Bpj.2009.12.2151 |
0.47 |
|
| 2010 |
Yirdaw RB, Mchaourab HS, Sharma S. Protein Conformational Dynamics Detected Via Fluorescence Fluctuation Spectroscopy Biophysical Journal. 98: 23a. DOI: 10.1016/J.Bpj.2009.12.139 |
0.754 |
|
| 2009 |
Zou P, McHaourab HS. Alternating access of the putative substrate-binding chamber in the ABC transporter MsbA. Journal of Molecular Biology. 393: 574-85. PMID 19715704 DOI: 10.1016/J.Jmb.2009.08.051 |
0.525 |
|
| 2009 |
Zou P, Bortolus M, McHaourab HS. Conformational cycle of the ABC transporter MsbA in liposomes: detailed analysis using double electron-electron resonance spectroscopy. Journal of Molecular Biology. 393: 586-97. PMID 19715702 DOI: 10.1016/J.Jmb.2009.08.050 |
0.558 |
|
| 2009 |
McHaourab HS, Godar JA, Stewart PL. Structure and mechanism of protein stability sensors: chaperone activity of small heat shock proteins. Biochemistry. 48: 3828-37. PMID 19323523 DOI: 10.1021/Bi900212J |
0.376 |
|
| 2009 |
Smriti, Zou P, McHaourab HS. Mapping daunorubicin-binding Sites in the ATP-binding cassette transporter MsbA using site-specific quenching by spin labels. The Journal of Biological Chemistry. 284: 13904-13. PMID 19278995 DOI: 10.1074/Jbc.M900837200 |
0.489 |
|
| 2009 |
Latham JC, Stein RA, Bornhop DJ, Mchaourab HS. Free-solution label-free detection of alpha-crystallin chaperone interactions by back-scattering interferometry. Analytical Chemistry. 81: 1865-71. PMID 19178288 DOI: 10.1021/Ac802327H |
0.42 |
|
| 2009 |
Kumar MS, Koteiche HA, Claxton DP, Mchaourab HS. Disulfide cross-links in the interaction of a cataract-linked alphaA-crystallin mutant with betaB1-crystallin. Febs Letters. 583: 175-9. PMID 19071118 DOI: 10.1016/J.Febslet.2008.11.047 |
0.314 |
|
| 2009 |
Hoffman L, Mchaourab HS. Structural dynamics of CaMKII activation Biophysical Journal. 96: 116a. DOI: 10.1016/J.Bpj.2008.12.511 |
0.393 |
|
| 2009 |
Alexander N, Mchaourab H, Meiler J. Membrane Protein Structure Determination by Coupling Sparse Experimental Data with Protein Structure Prediction Techniques Biophysical Journal. 96: 654a. DOI: 10.1016/J.Bpj.2008.12.3455 |
0.369 |
|
| 2009 |
Amadi ST, Koteiche HA, Mishra S, Mchaourab HS. The Structure and Dynamics of EmrE in Liposomes Biophysical Journal. 96: 272a. DOI: 10.1016/J.Bpj.2008.12.1345 |
0.507 |
|
| 2009 |
Claxton D, Quick M, Shi L, Chung L, Zhao Y, Weinstein H, Javitch JA, Mchaourab HS. Conformational Cycle Of A Bacterial Homolog Of Human Neurotransmitter Sodium Symporters Biophysical Journal. 96: 195a. DOI: 10.1016/J.Bpj.2008.12.1046 |
0.518 |
|
| 2008 |
McHaourab HS, Mishra S, Koteiche HA, Amadi SH. Role of sequence bias in the topology of the multidrug transporter EmrE. Biochemistry. 47: 7980-2. PMID 18616286 DOI: 10.1021/Bi800628D |
0.417 |
|
| 2008 |
Alexander N, Bortolus M, Al-Mestarihi A, Mchaourab H, Meiler J. De novo high-resolution protein structure determination from sparse spin-labeling EPR data. Structure (London, England : 1993). 16: 181-95. PMID 18275810 DOI: 10.1016/J.Str.2007.11.015 |
0.457 |
|
| 2008 |
Claxton DP, Zou P, Mchaourab HS. Structure and orientation of T4 lysozyme bound to the small heat shock protein alpha-crystallin. Journal of Molecular Biology. 375: 1026-39. PMID 18062989 DOI: 10.1016/J.Jmb.2007.11.014 |
0.508 |
|
| 2007 |
Cobb NJ, Sönnichsen FD, McHaourab H, Surewicz WK. Molecular architecture of human prion protein amyloid: a parallel, in-register beta-structure. Proceedings of the National Academy of Sciences of the United States of America. 104: 18946-51. PMID 18025469 DOI: 10.1073/Pnas.0706522104 |
0.368 |
|
| 2007 |
Borbat PP, Surendhran K, Bortolus M, Zou P, Freed JH, Mchaourab HS. Conformational motion of the ABC transporter MsbA induced by ATP hydrolysis. Plos Biology. 5: e271. PMID 17927448 DOI: 10.1371/Journal.Pbio.0050271 |
0.438 |
|
| 2007 |
McHaourab HS, Kumar MS, Koteiche HA. Specificity of alphaA-crystallin binding to destabilized mutants of betaB1-crystallin. Febs Letters. 581: 1939-43. PMID 17449033 DOI: 10.1016/J.Febslet.2007.04.005 |
0.397 |
|
| 2007 |
Koteiche HA, Kumar MS, McHaourab HS. Analysis of betaB1-crystallin unfolding equilibrium by spin and fluorescence labeling: evidence of a dimeric intermediate. Febs Letters. 581: 1933-8. PMID 17448466 DOI: 10.1016/J.Febslet.2007.04.004 |
0.457 |
|
| 2007 |
Mori T, Williams DR, Byrne MO, Qin X, Egli M, Mchaourab HS, Stewart PL, Johnson CH. Elucidating the ticking of an in vitro circadian clockwork. Plos Biology. 5: e93. PMID 17388688 DOI: 10.1371/Journal.Pbio.0050093 |
0.318 |
|
| 2007 |
Zou P, Surendhran K, Mchaourab HS. Distance measurements by fluorescence energy homotransfer: evaluation in T4 lysozyme and correlation with dipolar coupling between spin labels. Biophysical Journal. 92: L27-9. PMID 17142264 DOI: 10.1529/Biophysj.106.098913 |
0.473 |
|
| 2006 |
Shi J, Koteiche HA, McHaourab HS, Stewart PL. Cryoelectron microscopy and EPR analysis of engineered symmetric and polydisperse Hsp16.5 assemblies reveals determinants of polydispersity and substrate binding. The Journal of Biological Chemistry. 281: 40420-8. PMID 17079234 DOI: 10.1074/Jbc.M608322200 |
0.431 |
|
| 2006 |
Koteiche HA, Mchaourab HS. Mechanism of a hereditary cataract phenotype. Mutations in alphaA-crystallin activate substrate binding. The Journal of Biological Chemistry. 281: 14273-9. PMID 16531622 DOI: 10.1074/Jbc.M512938200 |
0.426 |
|
| 2005 |
Koteiche HA, Chiu S, Majdoch RL, Stewart PL, Mchaourab HS. Atomic models by cryo-EM and site-directed spin labeling: application to the N-terminal region of Hsp16.5. Structure (London, England : 1993). 13: 1165-71. PMID 16084388 DOI: 10.1016/J.Str.2005.05.006 |
0.438 |
|
| 2005 |
Altenbach C, Froncisz W, Hemker R, McHaourab H, Hubbell WL. Accessibility of nitroxide side chains: absolute Heisenberg exchange rates from power saturation EPR. Biophysical Journal. 89: 2103-12. PMID 15994891 DOI: 10.1529/Biophysj.105.059063 |
0.422 |
|
| 2005 |
Dong J, Yang G, McHaourab HS. Structural basis of energy transduction in the transport cycle of MsbA. Science (New York, N.Y.). 308: 1023-8. PMID 15890883 DOI: 10.1126/Science.1106592 |
0.768 |
|
| 2005 |
Shashidharamurthy R, Koteiche HA, Dong J, McHaourab HS. Mechanism of chaperone function in small heat shock proteins: dissociation of the HSP27 oligomer is required for recognition and binding of destabilized T4 lysozyme. The Journal of Biological Chemistry. 280: 5281-9. PMID 15542604 DOI: 10.1074/Jbc.M407236200 |
0.727 |
|
| 2004 |
Sathish HA, Koteiche HA, McHaourab HS. Binding of destabilized betaB2-crystallin mutants to alpha-crystallin: the role of a folding intermediate. The Journal of Biological Chemistry. 279: 16425-32. PMID 14761939 DOI: 10.1074/Jbc.M313402200 |
0.389 |
|
| 2003 |
Sathish HA, Stein RA, Yang G, Mchaourab HS. Mechanism of chaperone function in small heat-shock proteins. Fluorescence studies of the conformations of T4 lysozyme bound to alphaB-crystallin. The Journal of Biological Chemistry. 278: 44214-21. PMID 12928430 DOI: 10.1074/Jbc.M307578200 |
0.448 |
|
| 2003 |
Koteiche HA, Reeves MD, McHaourab HS. Structure of the substrate binding pocket of the multidrug transporter EmrE: site-directed spin labeling of transmembrane segment 1. Biochemistry. 42: 6099-105. PMID 12755611 DOI: 10.1021/Bi0342867 |
0.497 |
|
| 2003 |
Koteiche HA, McHaourab HS. Mechanism of chaperone function in small heat-shock proteins. Phosphorylation-induced activation of two-mode binding in alphaB-crystallin. The Journal of Biological Chemistry. 278: 10361-7. PMID 12529319 DOI: 10.1074/Jbc.M211851200 |
0.427 |
|
| 2002 |
Mchaourab HS, Dodson EK, Koteiche HA. Mechanism of chaperone function in small heat shock proteins. Two-mode binding of the excited states of T4 lysozyme mutants by alphaA-crystallin. The Journal of Biological Chemistry. 277: 40557-66. PMID 12189146 DOI: 10.1074/Jbc.M206250200 |
0.442 |
|
| 2002 |
Koteiche HA, Mchaourab HS. The determinants of the oligomeric structure in Hsp16.5 are encoded in the alpha-crystallin domain. Febs Letters. 519: 16-22. PMID 12023011 DOI: 10.1016/S0014-5793(02)02688-1 |
0.413 |
|
| 2002 |
Borbat PP, McHaourab HS, Freed JH. Protein structure determination using long-distance constraints from double-quantum coherence ESR: study of T4 lysozyme. Journal of the American Chemical Society. 124: 5304-14. PMID 11996571 DOI: 10.1021/Ja020040Y |
0.449 |
|
| 2002 |
Mansoor SE, McHaourab HS, Farrens DL. Mapping proximity within proteins using fluorescence spectroscopy. A study of T4 lysozyme showing that tryptophan residues quench bimane fluorescence. Biochemistry. 41: 2475-84. PMID 11851393 DOI: 10.1021/Bi011198I |
0.392 |
|
| 2000 |
Kaplan RS, Mayor JA, Kotaria R, Walters DE, McHaourab HS. The yeast mitochondrial citrate transport protein: determination of secondary structure and solvent accessibility of transmembrane domain IV using site-directed spin labeling. Biochemistry. 39: 9157-63. PMID 10924109 DOI: 10.1021/Bi000433E |
0.486 |
|
| 2000 |
Haley DA, Bova MP, Huang QL, Mchaourab HS, Stewart PL. Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies Journal of Molecular Biology. 298: 261-272. PMID 10764595 DOI: 10.1006/Jmbi.2000.3657 |
0.339 |
|
| 2000 |
Bova MP, McHaourab HS, Han Y, Fung BK. Subunit exchange of small heat shock proteins. Analysis of oligomer formation of alphaA-crystallin and Hsp27 by fluorescence resonance energy transfer and site-directed truncations. The Journal of Biological Chemistry. 275: 1035-42. PMID 10625643 DOI: 10.1074/Jbc.275.2.1035 |
0.421 |
|
| 2000 |
Koteiche HA, Mchaourab HS. Folding pattern of the alpha-crystallin domain in alphaA-crystallin determined by site-directed spin labeling. Journal of Molecular Biology. 294: 561-77. PMID 10610780 DOI: 10.1006/Jmbi.1999.3242 |
0.425 |
|
| 2000 |
Mansoor SE, McHaourab HS, Farrens DL. Determination of protein secondary structure and solvent accessibility using site-directed fluorescence labeling. Studies of T4 lysozyme using the fluorescent probe monobromobimane. Biochemistry. 38: 16383-93. PMID 10587464 DOI: 10.1021/Bi991331V |
0.419 |
|
| 1999 |
Barnes JP, Liang Z, Mchaourab HS, Freed JH, Hubbell WL. A multifrequency electron spin resonance study of T4 lysozyme dynamics. Biophysical Journal. 76: 3298-306. PMID 10354455 DOI: 10.1016/S0006-3495(99)77482-5 |
0.451 |
|
| 1999 |
Mchaourab HS, Kálai T, Hideg K, Hubbell WL. Motion of spin-labeled side chains in T4 lysozyme: effect of side chain structure. Biochemistry. 38: 2947-55. PMID 10074347 DOI: 10.1021/Bi9826310 |
0.424 |
|
| 1999 |
Berengian AR, Parfenova M, Mchaourab HS. Site-directed spin labeling study of subunit interactions in the alpha-crystallin domain of small heat-shock proteins. Comparison of the oligomer symmetry in alphaA-crystallin, HSP 27, and HSP 16.3. The Journal of Biological Chemistry. 274: 6305-14. PMID 10037719 DOI: 10.1074/Jbc.274.10.6305 |
0.402 |
|
| 1998 |
Koteiche HA, Berengian AR, Mchaourab HS. Identification of protein folding patterns using site-directed spin labeling. Structural characterization of a beta-sheet and putative substrate binding regions in the conserved domain of alpha A-crystallin. Biochemistry. 37: 12681-8. PMID 9737844 DOI: 10.1021/Bi9814078 |
0.471 |
|
| 1998 |
Mchaourab HS, Berengian AR, Koteiche HA. Site-directed spin-labeling study of the structure and subunit interactions along a conserved sequence in the alpha-crystallin domain of heat-shock protein 27. Evidence of a conserved subunit interface. Biochemistry. 36: 14627-34. PMID 9398181 DOI: 10.1021/Bi971700S |
0.401 |
|
| 1997 |
Berengian AR, Bova MP, Mchaourab HS. Structure and function of the conserved domain in alphaA-crystallin. Site-directed spin labeling identifies a beta-strand located near a subunit interface. Biochemistry. 36: 9951-7. PMID 9296605 DOI: 10.1021/Bi9712347 |
0.398 |
|
| 1997 |
Mchaourab HS, Oh KJ, Fang CJ, Hubbell WL. Conformation of T4 lysozyme in solution. Hinge-bending motion and the substrate-induced conformational transition studied by site-directed spin labeling Biochemistry. 36: 307-316. PMID 9003182 DOI: 10.1021/Bi962114M |
0.521 |
|
| 1996 |
Hubbell WL, Mchaourab HS, Altenbach C, Lietzow MA. Watching proteins move using site-directed spin labeling Structure. 4: 779-783. PMID 8805569 DOI: 10.1016/S0969-2126(96)00085-8 |
0.456 |
|
| 1996 |
Mchaourab HS, Lietzow MA, Hideg K, Hubbell WL. Motion of spin-labeled side chains in T4 lysozyme. Correlation with protein structure and dynamics Biochemistry. 35: 7692-7704. PMID 8672470 DOI: 10.1021/Bi960482K |
0.48 |
|
| 1995 |
Singh RJ, Hogg N, Mchaourab HS, Kalyanaraman B. Physical and chemical interactions between nitric oxide and nitroxides. Biochimica Et Biophysica Acta. 1201: 437-41. PMID 7803474 DOI: 10.1016/0304-4165(94)90073-6 |
0.33 |
|
| 1995 |
Singh RJ, Feix JB, Mchaourab HS, Hogg N, Kalyanaraman B. Spin-labeling study of the oxidative damage to low-density lipoprotein. Archives of Biochemistry and Biophysics. 320: 155-61. PMID 7793976 DOI: 10.1006/Abbi.1995.1354 |
0.363 |
|
| 1994 |
Mchaourab HS, Hyde JS, Feix JB. Binding and state of aggregation of spin-labeled cecropin AD in phospholipid bilayers: effects of surface charge and fatty acyl chain length. Biochemistry. 33: 6691-9. PMID 8204604 DOI: 10.1021/Bi00187A040 |
0.355 |
|
| 1993 |
Mchaourab HS, Hyde JS, Feix JB. Aggregation state of spin-labeled cecropin AD in solution. Biochemistry. 32: 11895-902. PMID 7692965 DOI: 10.1021/Bi00095A019 |
0.402 |
|
| 1993 |
Mchaourab HS, Christidis TC, Hyde JS. Continuous wave multiquantum electron paramagnetic resonance spectroscopy. IV. Multiquantum electron–nuclear double resonance The Journal of Chemical Physics. 99: 4975-4985. DOI: 10.1063/1.465999 |
0.34 |
|
| 1993 |
Mchaourab HS, Hyde JS. Continuous wave multiquantum electron paramagnetic resonance spectroscopy. III. Theory of intermodulation sidebands The Journal of Chemical Physics. 98: 1786-1796. DOI: 10.1063/1.464267 |
0.338 |
|
| 1991 |
Mchaourab HS, Christidis T, Froncisz W, Sczaniecki P, Hyde JS. Multiple-quantum electron-electron double resonance Journal of Magnetic Resonance (1969). 92: 429-433. DOI: 10.1016/0022-2364(91)90284-Z |
0.315 |
|
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