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Lu Chen - Publications

Affiliations: 
2003-2011 University of California, Berkeley, Berkeley, CA, United States 
 2011- Stanford University, Palo Alto, CA 
Website:
https://med.stanford.edu/profiles/lu-chen?tab=bio
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69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Thapliyal S, Arendt KL, Lau AG, Chen L. Correction: Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity. Elife. 12. PMID 37530757 DOI: 10.7554/eLife.91539  0.785
2023 Nugent FS, Li KW, Chen L. Editorial: Synaptic plasticity and dysfunction, friend or foe? Frontiers in Synaptic Neuroscience. 15: 1204605. PMID 37206953 DOI: 10.3389/fnsyn.2023.1204605  0.399
2022 Thapliyal S, Arendt KL, Lau AG, Chen L. Retinoic acid-gated BDNF synthesis in neuronal dendrites drives presynaptic homeostatic plasticity. Elife. 11. PMID 36515276 DOI: 10.7554/eLife.79863  0.834
2022 Ye X, Chen L, Wang H, Peng S, Liu M, Yao L, Zhang Y, Shi YS, Cao Y, Yang JJ, Chen G. Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease. Neuropathology and Applied Neurobiology. e12839. PMID 35881686 DOI: 10.1111/nan.12839  0.351
2022 Chen L, Li X, Tjia M, Thapliyal S. Homeostatic plasticity and excitation-inhibition balance: The good, the bad, and the ugly. Current Opinion in Neurobiology. 75: 102553. PMID 35594578 DOI: 10.1016/j.conb.2022.102553  0.319
2021 Park E, Lau AG, Arendt KL, Chen L. FMRP Interacts with RARα in Synaptic Retinoic Acid Signaling and Homeostatic Synaptic Plasticity. International Journal of Molecular Sciences. 22. PMID 34205274 DOI: 10.3390/ijms22126579  0.818
2020 Li J, Jiang RY, Arendt KL, Hsu YT, Zhai SR, Chen L. Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome. Elife. 9. PMID 33215988 DOI: 10.7554/eLife.61882  0.756
2019 Yang Y, Geng Y, Jiang D, Ning L, Kim HJ, Jeon NL, Lau A, Chen L, Lin MZ. Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 31118285 DOI: 10.1073/Pnas.1812056116  0.617
2019 Hsu YT, Li J, Wu D, Südhof TC, Chen L. Synaptic retinoic acid receptor signaling mediates mTOR-dependent metaplasticity that controls hippocampal learning. Proceedings of the National Academy of Sciences of the United States of America. PMID 30782829 DOI: 10.1073/Pnas.1820690116  0.66
2018 Zhong L, Chen X, Park E, Südhof TC, Chen L. Retinoic acid receptor RARα-dependent synaptic signaling mediates homeostatic synaptic plasticity at the inhibitory synapses of mouse visual cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30355624 DOI: 10.1523/Jneurosci.1133-18.2018  0.652
2018 Li J, Park E, Zhong LR, Chen L. Homeostatic synaptic plasticity as a metaplasticity mechanism - a molecular and cellular perspective. Current Opinion in Neurobiology. 54: 44-53. PMID 30212714 DOI: 10.1016/J.Conb.2018.08.010  0.485
2018 Zhang Z, Marro SG, Zhang Y, Arendt KL, Patzke C, Zhou B, Fair T, Yang N, Südhof TC, Wernig M, Chen L. The fragile X mutation impairs homeostatic plasticity in human neurons by blocking synaptic retinoic acid signaling. Science Translational Medicine. 10. PMID 30068571 DOI: 10.1126/Scitranslmed.Aar4338  0.817
2018 Park E, Tjia M, Zuo Y, Chen L. Postnatal ablation of synaptic retinoic acid signaling impairs cortical information processing and sensory discrimination in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29760176 DOI: 10.1523/Jneurosci.3028-17.2018  0.477
2017 Wang D, Wu F, Yuan H, Wang A, Kang GJ, Truong T, Chen L, McCallion AS, Gong X, Li S. Sox10+ Cells Contribute to Vascular Development in Multiple Organs. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28751573 DOI: 10.1161/Atvbaha.117.309774  0.528
2017 Temkin P, Morishita W, Goswami D, Arendt K, Chen L, Malenka R. The Retromer Supports AMPA Receptor Trafficking During LTP. Neuron. 94: 74-82.e5. PMID 28384478 DOI: 10.1016/J.Neuron.2017.03.020  0.802
2017 Wu D, Bacaj T, Morishita W, Goswami D, Arendt KL, Xu W, Chen L, Malenka RC, Südhof TC. Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Nature. PMID 28355182 DOI: 10.1038/Nature21720  0.818
2017 Keck T, Toyoizumi T, Chen L, Doiron B, Feldman DE, Fox K, Gerstner W, Haydon PG, Hübener M, Lee HK, Lisman JE, Rose T, Sengpiel F, Stellwagen D, Stryker MP, et al. Integrating Hebbian and homeostatic plasticity: the current state of the field and future research directions. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 28093552 DOI: 10.1098/Rstb.2016.0158  0.324
2017 Yee AX, Hsu YT, Chen L. A metaplasticity view of the interaction between homeostatic and Hebbian plasticity. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 28093549 DOI: 10.1098/Rstb.2016.0155  0.477
2016 Kang GJ, Truong T, Huang E, Su V, Ge S, Chen L. Integrin Alpha 9 Blockade Suppresses Lymphatic Valve Formation and Promotes Transplant Survival. Investigative Ophthalmology & Visual Science. 57: 5935-5939. PMID 27806381 DOI: 10.1167/iovs.16-20130  0.48
2016 Yee A, Chen L. Differential regulation of spontaneous and evoked inhibitory synaptic transmission in somatosensory cortex by retinoic acid. Synapse (New York, N.Y.). PMID 27348405 DOI: 10.1002/Syn.21921  0.538
2016 Hou JX, Cheng SS, Chen L, Wang QH, Shi Y, Xu Y, Yin ZY, Chen GQ. Astroglial Activation and Tau Hyperphosphorylation Precede to Neuron Loss in a Neurodegenerative Mouse Model. Cns Neuroscience & Therapeutics. PMID 26804055 DOI: 10.1111/Cns.12509  0.351
2016 Kang GJ, Ecoiffier T, Truong T, Yuen D, Li G, Lee N, Zhang L, Chen L. Intravital Imaging Reveals Dynamics of Lymphangiogenesis and Valvulogenesis. Scientific Reports. 6: 19459. PMID 26785921 DOI: 10.1038/srep19459  0.501
2015 Wang X, Wang S, Wang J, Guo H, Dong Z, Chai L, Hu L, Zhang Y, Wang H, Chen L. Neuroprotective Effect of Xueshuantong for Injection (Lyophilized) in Transient and Permanent Rat Cerebral Ischemia Model. Evidence-Based Complementary and Alternative Medicine : Ecam. 2015: 134685. PMID 26681963 DOI: 10.1155/2015/134685  0.316
2015 Arendt KL, Zhang Z, Ganesan S, Hintze M, Shin MM, Tang Y, Cho A, Graef IA, Chen L. Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26443861 DOI: 10.1073/Pnas.1510239112  0.831
2015 Kim JI, Ganesan S, Luo SX, Wu YW, Park E, Huang EJ, Chen L, Ding JB. Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons. Science (New York, N.Y.). 350: 102-6. PMID 26430123 DOI: 10.1126/Science.Aac4690  0.48
2015 Anderson GR, Aoto J, Tabuchi K, Földy C, Covy J, Yee AX, Wu D, Lee SJ, Chen L, Malenka RC, Südhof TC. β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling. Cell. 162: 593-606. PMID 26213384 DOI: 10.1016/J.Cell.2015.06.056  0.806
2015 Ding J, Zhang Q, Zhu J, Tao W, Wu Q, Chen L, Shi P, Zhang H. Risk factors for predicting cement leakage following percutaneous vertebroplasty for osteoporotic vertebral compression fractures. European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. PMID 25850391 DOI: 10.1007/s00586-015-3923-0  0.403
2015 Arendt KL, Zhang Y, Jurado S, Malenka RC, Südhof TC, Chen L. Retinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms. Neuron. 86: 442-56. PMID 25843403 DOI: 10.1016/J.Neuron.2015.03.009  0.822
2014 Truong TN, Li H, Hong YK, Chen L. Novel characterization and live imaging of Schlemm's canal expressing Prox-1. Plos One. 9: e98245. PMID 24827370 DOI: 10.1371/Journal.Pone.0098245  0.516
2014 Yuen D, Grimaldo S, Sessa R, Ecoiffier T, Truong T, Huang E, Bernas M, Daley S, Witte M, Chen L. Role of angiopoietin-2 in corneal lymphangiogenesis. Investigative Ophthalmology & Visual Science. 55: 3320-7. PMID 24781940 DOI: 10.1167/iovs.13-13779  0.491
2014 Truong T, Huang E, Yuen D, Chen L. Corneal lymphatic valve formation in relation to lymphangiogenesis. Investigative Ophthalmology & Visual Science. 55: 1876-83. PMID 24595382 DOI: 10.1167/iovs.13-12251  0.486
2014 Chen L, Lau AG, Sarti F. Synaptic retinoic acid signaling and homeostatic synaptic plasticity. Neuropharmacology. 78: 3-12. PMID 23270606 DOI: 10.1016/J.Neuropharm.2012.12.004  0.718
2013 Yu X, Wang G, Gilmore A, Yee AX, Li X, Xu T, Smith SJ, Chen L, Zuo Y. Accelerated experience-dependent pruning of cortical synapses in ephrin-A2 knockout mice. Neuron. 80: 64-71. PMID 24094103 DOI: 10.1016/J.Neuron.2013.07.014  0.388
2013 Sarti F, Zhang Z, Schroeder J, Chen L. Rapid suppression of inhibitory synaptic transmission by retinoic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11440-50. PMID 23843516 DOI: 10.1523/Jneurosci.1710-13.2013  0.769
2013 Zhang Y, Pak C, Han Y, Ahlenius H, Zhang Z, Chanda S, Marro S, Patzke C, Acuna C, Covy J, Xu W, Yang N, Danko T, Chen L, Wernig M, et al. Rapid single-step induction of functional neurons from human pluripotent stem cells. Neuron. 78: 785-98. PMID 23764284 DOI: 10.1016/J.Neuron.2013.05.029  0.62
2013 Hastie P, Ulbrich MH, Wang HL, Arant RJ, Lau AG, Zhang Z, Isacoff EY, Chen L. AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting. Proceedings of the National Academy of Sciences of the United States of America. 110: 5163-8. PMID 23479622 DOI: 10.1073/Pnas.1218765110  0.495
2013 Arendt KL, Sarti F, Chen L. Chronic inactivation of a neural circuit enhances LTP by inducing silent synapse formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2087-96. PMID 23365245 DOI: 10.1523/Jneurosci.3880-12.2013  0.835
2012 Sarti F, Schroeder J, Aoto J, Chen L. Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity. Frontiers in Molecular Neuroscience. 5: 16. PMID 22419906 DOI: 10.3389/Fnmol.2012.00016  0.821
2012 Choi I, Lee S, Kyoung Chung H, Suk Lee Y, Eui Kim K, Choi D, Park EK, Yang D, Ecoiffier T, Monahan J, Chen W, Aguilar B, Lee HN, Yoo J, Koh CJ, Chen L, et al. 9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. Circulation. 125: 872-82. PMID 22275501 DOI: 10.1161/Circulationaha.111.030296  0.319
2011 Wang HL, Zhang Z, Hintze M, Chen L. Decrease in calcium concentration triggers neuronal retinoic acid synthesis during homeostatic synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17764-71. PMID 22159093 DOI: 10.1523/Jneurosci.3964-11.2011  0.625
2011 Truong T, Altiok E, Yuen D, Ecoiffier T, Chen L. Novel characterization of lymphatic valve formation during corneal inflammation. Plos One. 6: e21918. PMID 21760922 DOI: 10.1371/journal.pone.0021918  0.488
2011 Tracy TE, Yan JJ, Chen L. Acute knockdown of AMPA receptors reveals a trans-synaptic signal for presynaptic maturation. The Embo Journal. 30: 1577-92. PMID 21378752 DOI: 10.1038/Emboj.2011.59  0.799
2010 Soden ME, Chen L. Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16910-21. PMID 21159962 DOI: 10.1523/Jneurosci.3660-10.2010  0.811
2008 Poon MM, Chen L. Retinoic acid-gated sequence-specific translational control by RARalpha. Proceedings of the National Academy of Sciences of the United States of America. 105: 20303-8. PMID 19073915 DOI: 10.1073/pnas.0807740105  0.598
2008 Aoto J, Nam CI, Poon MM, Ting P, Chen L. Synaptic signaling by all-trans retinoic acid in homeostatic synaptic plasticity. Neuron. 60: 308-20. PMID 18957222 DOI: 10.1016/J.Neuron.2008.08.012  0.82
2008 Maghsoodi B, Poon MM, Nam CI, Aoto J, Ting P, Chen L. Retinoic acid regulates RARalpha-mediated control of translation in dendritic RNA granules during homeostatic synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 105: 16015-20. PMID 18840692 DOI: 10.1073/Pnas.0804801105  0.813
2007 Aoto J, Ting P, Maghsoodi B, Xu N, Henkemeyer M, Chen L. Postsynaptic ephrinB3 promotes shaft glutamatergic synapse formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7508-19. PMID 17626212 DOI: 10.1523/Jneurosci.0705-07.2007  0.786
2007 Aoto J, Chen L. Bidirectional ephrin/Eph signaling in synaptic functions. Brain Research. 1184: 72-80. PMID 17166489 DOI: 10.1016/J.Brainres.2006.11.033  0.752
2007 Chen L, Tracy T, Nam CI. Dynamics of postsynaptic glutamate receptor targeting. Current Opinion in Neurobiology. 17: 53-8. PMID 17161597 DOI: 10.1016/J.Conb.2006.11.001  0.818
2007 Chen L, Maghsoodi B. Synaptic Trafficking of AMPA Receptors Protein Trafficking in Neurons. 175-201. DOI: 10.1016/B978-012369437-9/50014-1  0.389
2005 Nam CI, Chen L. Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America. 102: 6137-42. PMID 15837930 DOI: 10.1073/Pnas.0502038102  0.826
2003 Chen L, El-Husseini A, Tomita S, Bredt DS, Nicoll RA. Stargazin differentially controls the trafficking of alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate and kainate receptors. Molecular Pharmacology. 64: 703-6. PMID 12920207 DOI: 10.1124/Mol.64.3.703  0.606
2003 Tomita S, Chen L, Kawasaki Y, Petralia RS, Wenthold RJ, Nicoll RA, Bredt DS. Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins. The Journal of Cell Biology. 161: 805-16. PMID 12771129 DOI: 10.1083/Jcb.200212116  0.57
2002 Schnell E, Sizemore M, Karimzadegan S, Chen L, Bredt DS, Nicoll RA. Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number. Proceedings of the National Academy of Sciences of the United States of America. 99: 13902-7. PMID 12359873 DOI: 10.1073/Pnas.172511199  0.77
2002 Chetkovich DM, Chen L, Stocker TJ, Nicoll RA, Bredt DS. Phosphorylation of the postsynaptic density-95 (PSD-95)/discs large/zona occludens-1 binding site of stargazin regulates binding to PSD-95 and synaptic targeting of AMPA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 5791-6. PMID 12122038 DOI: 10.1523/Jneurosci.22-14-05791.2002  0.62
2002 Bao S, Chen L, Kim JJ, Thompson RF. Cerebellar cortical inhibition and classical eyeblink conditioning. Proceedings of the National Academy of Sciences of the United States of America. 99: 1592-7. PMID 11805298 DOI: 10.1073/Pnas.032655399  0.756
2000 Chen L, Chetkovich DM, Petralia RS, Sweeney NT, Kawasaki Y, Wenthold RJ, Bredt DS, Nicoll RA. Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms. Nature. 408: 936-43. PMID 11140673 DOI: 10.1038/35050030  0.607
2000 Bao S, Chen L, Thompson RF. Learning- and cerebellum-dependent neuronal activity in the lateral pontine nucleus. Behavioral Neuroscience. 114: 254-61. PMID 10832787 DOI: 10.1037//0735-7044.114.2.254  0.675
1999 Chen L, Bao S, Qiao X, Thompson RF. Impaired cerebellar synapse maturation in waggler, a mutant mouse with a disrupted neuronal calcium channel gamma subunit. Proceedings of the National Academy of Sciences of the United States of America. 96: 12132-7. PMID 10518588 DOI: 10.1073/Pnas.96.21.12132  0.769
1999 Bao S, Chen L, Qiao X, Thompson RF. Transgenic brain-derived neurotrophic factor modulates a developing cerebellar inhibitory synapse. Learning & Memory (Cold Spring Harbor, N.Y.). 6: 276-83. PMID 10492009 DOI: 10.1101/Lm.6.3.276  0.739
1999 Chen L, Bao S, Thompson RF. Bilateral lesions of the interpositus nucleus completely prevent eyeblink conditioning in Purkinje cell-degeneration mutant mice. Behavioral Neuroscience. 113: 204-10. PMID 10197920 DOI: 10.1037/0735-7044.113.1.204  0.681
1998 Bao S, Chen L, Qiao X, Knusel B, Thompson RF. Impaired eye-blink conditioning in waggler, a mutant mouse with cerebellar BDNF deficiency. Learning & Memory (Cold Spring Harbor, N.Y.). 5: 355-64. PMID 10454360 DOI: 10.1101/Lm.5.4.355  0.724
1998 Qiao X, Chen L, Gao H, Bao S, Hefti F, Thompson RF, Knusel B. Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in Stargazer mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6990-9. PMID 9712667 DOI: 10.1523/Jneurosci.18-17-06990.1998  0.719
1998 Bao S, Chen L, Thompson RF. Classical eyeblink conditioning in two strains of mice: conditioned responses, sensitization, and spontaneous eyeblinks. Behavioral Neuroscience. 112: 714-8. PMID 9676986 DOI: 10.1037//0735-7044.112.3.714  0.664
1997 Thompson RF, Bao S, Chen L, Cipriano BD, Grethe JS, Kim JJ, Thompson JK, Tracy JA, Weninger MS, Krupa DJ. Associative learning. International Review of Neurobiology. 41: 151-89. PMID 9378587  0.751
1997 Kim JJ, Shih JC, Chen K, Chen L, Bao S, Maren S, Anagnostaras SG, Fanselow MS, De Maeyer E, Seif I, Thompson RF. Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 5929-33. PMID 9159177 DOI: 10.1073/Pnas.94.11.5929  0.766
1996 Chen L, Bao S, Lockard JM, Kim JK, Thompson RF. Impaired classical eyeblink conditioning in cerebellar-lesioned and Purkinje cell degeneration (pcd) mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2829-38. PMID 8786457 DOI: 10.1523/Jneurosci.16-08-02829.1996  0.697
1996 Shibuki K, Gomi H, Chen L, Bao S, Kim JJ, Wakatsuki H, Fujisaki T, Fujimoto K, Katoh A, Ikeda T, Chen C, Thompson RF, Itohara S. Deficient cerebellar long-term depression, impaired eyeblink conditioning, and normal motor coordination in GFAP mutant mice. Neuron. 16: 587-99. PMID 8785056 DOI: 10.1016/S0896-6273(00)80078-1  0.793
1995 Chen C, Kano M, Abeliovich A, Chen L, Bao S, Kim JJ, Hashimoto K, Thompson RF, Tonegawa S. Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell. 83: 1233-42. PMID 8548809 DOI: 10.1016/0092-8674(95)90148-5  0.744
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