| Year |
Citation |
Score |
| 2020 |
Wan Q, Jin X, Guo Y, Yu Z, Guo S, Morris-Natschke S, Lee KH, Liu H, Chen Y. New Seco-DSP derivatives as potent chemosensitizers. European Journal of Medicinal Chemistry. 204: 112555. PMID 32750634 DOI: 10.1016/J.Ejmech.2020.112555 |
0.38 |
|
| 2020 |
Qian J, Xu Z, Meng C, Liu J, Hsu PL, Li Y, Zhu W, Yang Y, Morris-Natschke SL, Lee KH, Zhang Y, Ling Y. Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy. European Journal of Medicinal Chemistry. 204: 112610. PMID 32736231 DOI: 10.1016/J.Ejmech.2020.112610 |
0.349 |
|
| 2020 |
Shang XF, Yang CJ, Morris-Natschke SL, Li JC, Yin XD, Liu YQ, Guo X, Peng JW, Goto M, Zhang JY, Lee KH. Biologically active isoquinoline alkaloids covering 2014-2018. Medicinal Research Reviews. PMID 32729169 DOI: 10.1002/Med.21703 |
0.318 |
|
| 2020 |
Huang XL, Chen JL, Li XL, Zhao L, Cui YD, Liu JY, Morris-Natschke SL, Masuo G, Cheng YY, Lee KH, Chen DF, Zhang J. Synthesis and anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin. Journal of Asian Natural Products Research. 1-9. PMID 32441118 DOI: 10.1080/10286020.2020.1760851 |
0.317 |
|
| 2020 |
Yuan WH, Teng MT, Yun YF, Jiang N, Ma L, Sun SS, Yuan B, Tang J, Wu QY, Li Q, Zhang P, Morris-Natschke SL, Lee KH. Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus sp. Journal of Natural Products. PMID 32315180 DOI: 10.1021/Acs.Jnatprod.0C00024 |
0.32 |
|
| 2020 |
Lee DY, Hou YC, Yang JS, Lin HY, Chang TY, Lee KH, Kuo SC, Hsieh MT. Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives. Molecules (Basel, Switzerland). 25. PMID 31979200 DOI: 10.3390/Molecules25030479 |
0.452 |
|
| 2020 |
Jiang L, Goto M, Zhu DQ, Hsu PL, Li KP, Cui M, He X, Morris-Natschke SL, Lee KH, Xie L. Scaffold Hopping-Driven Optimization of 4-(Quinazolin-4-yl)-3,4-dihydroquinoxalin-2(1)-ones as Novel Tubulin Inhibitors. Acs Medicinal Chemistry Letters. 11: 83-89. PMID 31938468 DOI: 10.1021/Acsmedchemlett.9B00352 |
0.404 |
|
| 2019 |
Yang CJ, Li B, Zhang ZJ, Gao JM, Wang MJ, Zhao XB, Song ZL, Liu YQ, Li H, Chen Y, Lee KH, Morris-Natschke SL, Xu C. Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin. European Journal of Medicinal Chemistry. 187: 111971. PMID 31881457 DOI: 10.1016/J.Ejmech.2019.111971 |
0.427 |
|
| 2019 |
Chen Z, Huang KY, Ling Y, Goto M, Duan HQ, Tong XH, Liu YL, Cheng YY, Morris-Natschke SL, Yang PC, Yang SL, Lee KH. Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer. Journal of Natural Products. PMID 31718182 DOI: 10.1021/Acs.Jnatprod.9B00659 |
0.346 |
|
| 2019 |
Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of . Molecules (Basel, Switzerland). 24. PMID 31694283 DOI: 10.3390/molecules24214005 |
0.399 |
|
| 2019 |
Otsuki K, Li W, Asada Y, Chen CH, Lee KH, Koike K. Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from . Organic Letters. PMID 31680527 DOI: 10.1021/Acs.Orglett.9B03539 |
0.316 |
|
| 2019 |
Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Prenylated Acetophloroglucinol Dimers from : Structure Elucidation and Total Synthesis. Journal of Natural Products. PMID 31550158 DOI: 10.1021/Acs.Jnatprod.9B00596 |
0.319 |
|
| 2019 |
Jing L, Wu G, Hao X, Olotu FA, Kang D, Chen CH, Lee KH, Soliman MES, Liu X, Song Y, Zhan P. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. European Journal of Medicinal Chemistry. 183: 111696. PMID 31541869 DOI: 10.1016/J.Ejmech.2019.111696 |
0.335 |
|
| 2019 |
Yamashita H, Miyao M, Hiramori K, Kobayashi D, Suzuki Y, Mizukami M, Goto M, Lee KH, Wada K. Cytotoxic diterpenoid alkaloid from Aconitum japonicum subsp. subcuneatum. Journal of Natural Medicines. PMID 31346973 DOI: 10.1007/S11418-019-01346-Z |
0.304 |
|
| 2019 |
Wang GK, Jin WF, Zhang N, Wang G, Cheng YY, Morris-Natschke SL, Goto M, Zhou ZY, Liu JS, Lee KH. Kalshiolin A, new lignan from . Journal of Asian Natural Products Research. 1-7. PMID 31190564 DOI: 10.1080/10286020.2019.1592164 |
0.332 |
|
| 2019 |
Zhang Y, Goto M, Oda A, Hsu PL, Guo LL, Fu YH, Morris-Natschke SL, Hamel E, Lee KH, Hao XJ. Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Inhibit Tubulin Polymerization. Molecules (Basel, Switzerland). 24. PMID 30935100 DOI: 10.3390/molecules24071256 |
0.355 |
|
| 2019 |
Song ZL, Yang GZ, Li JC, Liu YQ, Yang CJ, Goto M, Zhang ZJ, Morris-Natschke SL, Liu H, Lee KH. Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents. Natural Product Research. 1-8. PMID 30784310 DOI: 10.1080/14786419.2019.1573231 |
0.452 |
|
| 2019 |
Wu H, Ma G, Yang Q, Zhu Y, Huang L, Tian Y, Yang X, Zhang M, Chen CH, Morris-Natschke SL, Yang M, Xu X, Lee KH. Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity. European Journal of Medicinal Chemistry. 166: 159-166. PMID 30703659 DOI: 10.1016/J.Ejmech.2019.01.020 |
0.346 |
|
| 2019 |
Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, et al. Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. Journal of Medicinal Chemistry. PMID 30624934 DOI: 10.1021/Acs.Jmedchem.8B01656 |
0.317 |
|
| 2018 |
Guo Y, Wang K, Chen X, Li H, Wan Q, Morris-Natschke S, Lee KH, Chen Y. Seco-4-methyl-DCK derivatives as potent chemosensitizers. Bioorganic & Medicinal Chemistry Letters. PMID 30455148 DOI: 10.1016/J.Bmcl.2018.11.023 |
0.402 |
|
| 2018 |
Zhao YF, Zhang YW, Wang Y, Morris-Natschke SL, Liu W, Shang TT, Yin H, Lee KH, Huang XF. New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III. Natural Product Research. 1-7. PMID 30453752 DOI: 10.1080/14786419.2018.1499640 |
0.417 |
|
| 2018 |
Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Journal of Natural Products. PMID 30106296 DOI: 10.1021/Acs.Jnatprod.8B00411 |
0.374 |
|
| 2018 |
Rahim A, Saito Y, Miyake K, Goto M, Chen CH, Alam G, Morris-Natschke S, Lee KH, Nakagawa-Goto K. Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita. Journal of Natural Products. PMID 30010341 DOI: 10.1021/acs.jnatprod.8b00211 |
0.408 |
|
| 2018 |
Hsieh MT, Huang LJ, Wu TS, Lin HY, Morris-Natschke SL, Lee KH, Kuo SC. Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells. Bioorganic & Medicinal Chemistry. PMID 29908756 DOI: 10.1016/j.bmc.2018.06.011 |
0.392 |
|
| 2018 |
Ling Y, Yang QX, Teng YN, Chen S, Gao WJ, Guo J, Hsu PL, Liu Y, Morris-Natschke SL, Hung CC, Lee KH. Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities. European Journal of Medicinal Chemistry. 154: 199-209. PMID 29803003 DOI: 10.1016/j.ejmech.2018.05.025 |
0.369 |
|
| 2018 |
Jing L, Tang Y, Goto M, Lee KH, Xiao Z. SAR study on ,-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents. Rsc Advances. 8: 11871-11885. PMID 29682280 DOI: 10.1039/C8Ra01440J |
0.394 |
|
| 2018 |
Tian Y, Liu Z, Liu J, Huang B, Kang D, Zhang H, De Clercq E, Daelemans D, Pannecouque C, Lee KH, Chen CH, Zhan P, Liu X. Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. European Journal of Medicinal Chemistry. 151: 339-350. PMID 29635166 DOI: 10.1016/J.Ejmech.2018.03.059 |
0.382 |
|
| 2018 |
Wang YR, Yu Y, Li SM, Liu W, Li W, Morris-Natschke SL, Goto M, Lee KH, Huang XF. Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root. Chemistry & Biodiversity. PMID 29451710 DOI: 10.1002/cbdv.201800019 |
0.317 |
|
| 2018 |
Zhang Y, Yuan YX, Goto M, Guo LL, Li XN, Morris-Natschke SL, Lee KH, Hao XJ. Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa. Journal of Natural Products. PMID 29319316 DOI: 10.1021/acs.jnatprod.7b00949 |
0.345 |
|
| 2017 |
Zhao Y, Liu PY, Hsieh KY, Hsu PL, Goto M, Morris-Natschke SL, Harn HJ, Lee KH. Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives. Medchemcomm. 8: 2040-2049. PMID 29391939 DOI: 10.1039/C7MD00310B |
0.359 |
|
| 2017 |
Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa. The Journal of Organic Chemistry. PMID 29286245 DOI: 10.1021/acs.joc.7b02951 |
0.341 |
|
| 2017 |
Chen Z, Duan H, Tong X, Hsu P, Han L, Morris-Natschke SL, Yang S, Liu W, Lee KH. Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives. Journal of Natural Products. PMID 29131631 DOI: 10.1021/acs.jnatprod.7b00578 |
0.441 |
|
| 2017 |
Yang CJ, Song ZL, Goto M, Hsu PL, Zhang XS, Yang QR, Liu YQ, Wang MJ, Morris-Natschke SL, Shang XF, Lee KH. Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28927790 DOI: 10.1016/j.bmcl.2017.09.012 |
0.421 |
|
| 2017 |
Yuan YX, Zhang Y, Guo LL, Wang YH, Goto M, Morris-Natschke SL, Lee KH, Hao XJ. Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa. Organic Letters. PMID 28876071 DOI: 10.1021/acs.orglett.7b02445 |
0.32 |
|
| 2017 |
Yang CJ, Song ZL, Goto M, Liu YQ, Hsieh KY, Morris-Natschke SL, Zhao YL, Zhang JX, Lee KH. Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties. Bioorganic & Medicinal Chemistry Letters. PMID 28789891 DOI: 10.1016/j.bmcl.2017.07.078 |
0.403 |
|
| 2017 |
Zhou A, Yan L, Lai F, Chen X, Goto M, Lee KH, Xiao Z. Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds. Bioorganic & Medicinal Chemistry Letters. PMID 28625363 DOI: 10.1016/J.Bmcl.2017.06.019 |
0.364 |
|
| 2017 |
Luo P, Xia W, Morris-Natschke SL, Lee KH, Zhao Y, Gu Q, Xu J. Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia. Journal of Natural Products. PMID 28453270 DOI: 10.1021/acs.jnatprod.6b01195 |
0.376 |
|
| 2017 |
Hsieh MT, Chang LC, Hung HY, Lin HY, Shih MH, Tsai CH, Kuo SC, Lee KH. New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo. European Journal of Medicinal Chemistry. 131: 141-151. PMID 28319780 DOI: 10.1016/j.ejmech.2017.03.006 |
0.376 |
|
| 2017 |
Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa. Journal of Natural Products. PMID 28290698 DOI: 10.1021/acs.jnatprod.6b01151 |
0.326 |
|
| 2017 |
Zhu GX, Cheng PL, Goto M, Zhang N, Morris-Natschke SL, Hsieh KY, Yang GZ, Yang QR, Liu YQ, Chen HL, Zhang XS, Lee KH. Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28285912 DOI: 10.1016/j.bmcl.2017.02.066 |
0.445 |
|
| 2016 |
Morita C, Kobayashi Y, Saito Y, Miyake K, Tokuda H, Suzuki N, Ichiishi E, Lee KH, Nakagawa-Goto K. Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. 79: 2890-2897. PMID 27933896 DOI: 10.1021/acs.jnatprod.6b00646 |
0.381 |
|
| 2016 |
Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K. Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. PMID 27797192 DOI: 10.1021/acs.jnatprod.6b00645 |
0.414 |
|
| 2016 |
Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M. Triethylated chromones with substituted naphthalenes as tubulin inhibitors. Bioorganic & Medicinal Chemistry. PMID 27707623 DOI: 10.1016/j.bmc.2016.09.062 |
0.412 |
|
| 2016 |
Wang SB, Cui MT, Wang XF, Ohkoshi E, Goto M, Yang DX, Li L, Yuan S, Morris-Natschke SL, Lee KH, Xie L. Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. PMID 27238842 DOI: 10.1016/j.bmc.2016.05.025 |
0.629 |
|
| 2016 |
Liu N, Wei L, Huang L, Yu F, Zheng W, Qin B, Zhu DQ, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L. Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus. Journal of Medicinal Chemistry. PMID 27070547 DOI: 10.1021/acs.jmedchem.5b01827 |
0.331 |
|
| 2016 |
Song ZL, Wang MJ, Li L, Wu D, Wang YH, Yan LT, Morris-Natschke SL, Liu YQ, Zhao YL, Wang CY, Liu H, Goto M, Liu H, Zhu GX, Lee KH. Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives. European Journal of Medicinal Chemistry. 115: 109-120. PMID 26994847 DOI: 10.1016/j.ejmech.2016.02.070 |
0.416 |
|
| 2016 |
Shih HC, Kuo PC, Wu SJ, Hwang TL, Hung HY, Shen DY, Shieh PC, Liao YR, Lee EJ, Gu Q, Lee KH, Wu TS. Anti-inflammatory neolignans from the roots of Magnolia officinalis. Bioorganic & Medicinal Chemistry. PMID 26928286 DOI: 10.1016/J.Bmc.2016.01.049 |
0.349 |
|
| 2016 |
Lin YC, Chen YF, Tseng LS, Lee YH, Morris-Natschke SL, Kuo SC, Yang NS, Lee KH, Huang LJ. Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells. European Journal of Medicinal Chemistry. 110: 98-114. PMID 26820553 DOI: 10.1016/j.ejmech.2016.01.004 |
0.421 |
|
| 2016 |
Jiang C, Luo P, Zhao Y, Hong J, Morris-Natschke SL, Xu J, Chen CH, Lee KH, Gu Q. Carolignans from the Aerial Parts of Euphorbia sikkimensis and Their Anti-HIV Activity. Journal of Natural Products. PMID 26756779 DOI: 10.1021/acs.jnatprod.5b01012 |
0.313 |
|
| 2015 |
Tan CJ, Zhao Y, Goto M, Hsieh KY, Yang XM, Morris-Natschke SL, Liu LN, Zhao BY, Lee KH. Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. Bioorganic & Medicinal Chemistry Letters. PMID 26865176 DOI: 10.1016/j.bmcl.2015.09.010 |
0.4 |
|
| 2015 |
Wang SB, Wang XF, Qin B, Ohkoshi E, Hsieh KY, Hamel E, Cui MT, Zhu DQ, Goto M, Morris-Natschke SL, Lee KH, Xie L. Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. PMID 26242242 DOI: 10.1016/j.bmc.2015.07.016 |
0.622 |
|
| 2015 |
Wu T, Jiang C, Wang L, Morris-Natschke SL, Miao H, Gu L, Xu J, Lee KH, Gu Q. 3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease. Journal of Natural Products. PMID 26099993 DOI: 10.1021/acs.jnatprod.5b00156 |
0.32 |
|
| 2015 |
Gao J, Fang C, Xiao Z, Huang L, Chen CH, Wang LT, Lee KH. Discovery of novel 5-fluoro-N (2),N (4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9. Medchemcomm. 6: 444-454. PMID 25914804 DOI: 10.1039/C4Md00412D |
0.41 |
|
| 2015 |
Wada K, Ohkoshi E, Zhao Y, Goto M, Morris-Natschke SL, Lee KH. Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents. Bioorganic & Medicinal Chemistry Letters. 25: 1525-31. PMID 25770782 DOI: 10.1016/j.bmcl.2015.02.018 |
0.335 |
|
| 2015 |
Wu T, Wang Q, Jiang C, Morris-Natschke SL, Cui H, Wang Y, Yan Y, Xu J, Lee KH, Gu Q. Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. Journal of Natural Products. 78: 500-9. PMID 25647077 DOI: 10.1021/np500988m |
0.356 |
|
| 2014 |
Zhao XB, Wu D, Wang MJ, Goto M, Morris-Natschke SL, Liu YQ, Wu XB, Song ZL, Zhu GX, Lee KH. Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry. 22: 6453-8. PMID 25438769 DOI: 10.1016/j.bmc.2014.09.035 |
0.355 |
|
| 2014 |
Wang YH, Goto M, Wang LT, Hsieh KY, Morris-Natschke SL, Tang GH, Long CL, Lee KH. Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues. Bioorganic & Medicinal Chemistry Letters. 24: 4818-21. PMID 25241925 DOI: 10.1016/j.bmcl.2014.08.063 |
0.355 |
|
| 2014 |
Wang S, Li RJ, Zhu RX, Hu XY, Guo YX, Zhou JC, Lin ZM, Zhang JZ, Wu JY, Kang YQ, Morris-Natschke SL, Lee KH, Yuan HQ, Lou HX. Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens. Journal of Natural Products. 77: 2081-7. PMID 25226363 DOI: 10.1021/np5004559 |
0.357 |
|
| 2014 |
Liu N, Qin B, Sun LQ, Yu F, Lu L, Jiang S, Lee KH, Xie L. Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors Bioorganic and Medicinal Chemistry Letters. 24: 3719-3723. PMID 25042339 DOI: 10.1016/j.bmcl.2014.07.011 |
0.354 |
|
| 2014 |
Zhao XB, Goto M, Song ZL, Morris-Natschke SL, Zhao Y, Wu D, Yang L, Li SG, Liu YQ, Zhu GX, Wu XB, Lee KH. Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 24: 3850-3. PMID 25008456 DOI: 10.1016/j.bmcl.2014.06.060 |
0.433 |
|
| 2014 |
Li RJ, Sun Y, Sun B, Wang XN, Liu SS, Zhou JC, Ye JP, Zhao Y, Liu L, Lee KH, Lou HX. Phytotoxic cis-clerodane diterpenoids from the Chinese liverwort Scapania stephanii. Phytochemistry. 105: 85-91. PMID 24947338 DOI: 10.1016/j.phytochem.2014.05.019 |
0.509 |
|
| 2014 |
Wang YH, Morris-Natschke SL, Yang J, Niu HM, Long CL, Lee KH. Anticancer principles from medicinal piper ( hú jiāo) plants. Journal of Traditional and Complementary Medicine. 4: 8-16. PMID 24872928 DOI: 10.4103/2225-4110.124811 |
0.328 |
|
| 2014 |
Shi LS, Kuo SC, Sun HD, Morris-Natschke SL, Lee KH, Wu TS. Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria. Bioorganic & Medicinal Chemistry. 22: 1889-98. PMID 24582402 DOI: 10.1016/j.bmc.2014.01.052 |
0.415 |
|
| 2014 |
Kou L, Wang MJ, Wang LT, Zhao XB, Nan X, Yang L, Liu YQ, Morris-Natschke SL, Lee KH. Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions. European Journal of Medicinal Chemistry. 75: 282-8. PMID 24553146 DOI: 10.1016/j.ejmech.2014.01.038 |
0.376 |
|
| 2014 |
Wang XF, Guan F, Ohkoshi E, Guo W, Wang L, Zhu DQ, Wang SB, Wang LT, Hamel E, Yang D, Li L, Qian K, Morris-Natschke SL, Yuan S, Lee KH, et al. Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. Journal of Medicinal Chemistry. 57: 1390-402. PMID 24502232 DOI: 10.1021/Jm4016526 |
0.616 |
|
| 2014 |
Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Bori ID, Qian K, Lee KH. A-ring modified betulinic acid derivatives as potent cancer preventive agents. Bioorganic & Medicinal Chemistry Letters. 24: 1005-8. PMID 24411124 DOI: 10.1016/J.Bmcl.2013.12.041 |
0.38 |
|
| 2014 |
Zhang ZJ, Tian J, Wang LT, Wang MJ, Nan X, Yang L, Liu YQ, Morris-Natschke SL, Lee KH. Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorganic & Medicinal Chemistry. 22: 204-10. PMID 24332656 DOI: 10.1016/j.bmc.2013.11.035 |
0.421 |
|
| 2014 |
Yu FL, He XY, Gu C, Ohkoshi E, Wang LT, Wang SB, Lai CY, Yu L, Morris-Natschke SL, Lee KH, Liu S, Xie L. Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway. Bioorganic & Medicinal Chemistry. 22: 325-33. PMID 24315191 DOI: 10.1016/j.bmc.2013.11.018 |
0.338 |
|
| 2013 |
Wang XF, Wang SB, Ohkoshi E, Wang LT, Hamel E, Qian K, Morris-Natschke SL, Lee KH, Xie L. N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin. European Journal of Medicinal Chemistry. 67: 196-207. PMID 23867604 DOI: 10.1016/J.Ejmech.2013.06.041 |
0.654 |
|
| 2013 |
Li WQ, Wang XL, Qian K, Liu YQ, Wang CY, Yang L, Tian J, Morris-Natschke SL, Zhou XW, Lee KH. Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives. Bioorganic & Medicinal Chemistry. 21: 2363-9. PMID 23490151 DOI: 10.1016/J.Bmc.2013.01.069 |
0.63 |
|
| 2013 |
Chen M, Xu X, Xu B, Yang P, Liao Z, Morris-Natschke SL, Lee KH, Chen D. Neglschisandrins E-F: two new lignans and related cytotoxic lignans from Schisandra neglecta. Molecules (Basel, Switzerland). 18: 2297-306. PMID 23429345 DOI: 10.3390/Molecules18022297 |
0.371 |
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| 2013 |
Wang XF, Ohkoshi E, Wang SB, Hamel E, Bastow KF, Morris-Natschke SL, Lee KH, Xie L. Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. 21: 632-42. PMID 23274123 DOI: 10.1016/j.bmc.2012.11.047 |
0.622 |
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| 2012 |
Wang XF, Tian XT, Ohkoshi E, Qin B, Liu YN, Wu PC, Hour MJ, Hung HY, Qian K, Huang R, Bastow KF, Janzen WP, Jin J, Morris-Natschke SL, Lee KH, et al. Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents. Bioorganic & Medicinal Chemistry Letters. 22: 6224-8. PMID 22932313 DOI: 10.1016/J.Bmcl.2012.08.014 |
0.633 |
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| 2012 |
Wang LT, Pan SL, Chen TH, Dong Y, Lee KH, Teng CM. DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells. Chembiochem : a European Journal of Chemical Biology. 13: 1663-72. PMID 22761044 DOI: 10.1002/Cbic.201200191 |
0.375 |
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| 2012 |
Huang HC, Chiou CT, Hsiao PC, Liaw CC, Zhang LJ, Chang CL, Chen IS, Chen WC, Lee KH, Kuo YH. Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai. Molecules (Basel, Switzerland). 17: 1837-51. PMID 22334062 DOI: 10.3390/molecules17021837 |
0.342 |
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| 2011 |
Soares J, Keppler BR, Wang X, Lee KH, Jarstfer MB. ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide. Bioorganic & Medicinal Chemistry Letters. 21: 7474-8. PMID 22044621 DOI: 10.1016/J.Bmcl.2011.09.112 |
0.516 |
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| 2011 |
Xie BB, Shang MY, Wang X, Cai SQ, Lee KH. [A new aristolochic acid derivative from Asarum himalaicum]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 46: 188-92. PMID 21542290 |
0.528 |
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| 2011 |
Xie BB, Shang MY, Lee KH, Wang X, Komatsu K, Cai SQ. 5-methoxyaristololactam I, the first natural 5-substituted aristololactam from Asarum ichangense. Natural Product Communications. 6: 11-4. PMID 21366036 |
0.576 |
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| 2010 |
Tian X, Qin B, Wu Z, Wang X, Lu H, Morris-Natschke SL, Chen CH, Jiang S, Lee KH, Xie L. Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 53: 8287-97. PMID 21049929 DOI: 10.1021/jm100738d |
0.596 |
|
| 2009 |
Dong Y, Shi Q, Liu YN, Wang X, Bastow KF, Lee KH. Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents. Journal of Medicinal Chemistry. 52: 3586-90. PMID 19425534 DOI: 10.1021/Jm9001567 |
0.608 |
|
| 2008 |
Magalhães R, Wang XW, Gouk SS, Lee KH, Ten CM, Yu H, Kuleshova LL. Vitrification successfully preserves hepatocyte spheroids. Cell Transplantation. 17: 813-28. PMID 19044208 DOI: 10.3727/096368908786516765 |
0.468 |
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| 2007 |
Wang X, Morris-Natschke SL, Lee KH. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Medicinal Research Reviews. 27: 133-48. PMID 16888751 DOI: 10.1002/med.20077 |
0.595 |
|
| 2006 |
Kwon YC, Yun YH, Lee KH, Son KY, Park SM, Chang YJ, Wang XS, Mendoza TR, Cleeland CS. Symptoms in the lives of terminal cancer patients: which is the most important? Oncology. 71: 69-76. PMID 17344672 DOI: 10.1159/000100450 |
0.45 |
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| 2006 |
Wang X, Nakagawa-Goto K, Bastow KF, Don MJ, Lin YL, Wu TS, Lee KH. Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents. Journal of Medicinal Chemistry. 49: 5631-4. PMID 16942038 DOI: 10.1021/Jm060184D |
0.631 |
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| 2006 |
Sakurai Y, Sakurai N, Taniguchi M, Nakanishi Y, Bastow KF, Wang X, Cragg GM, Lee KH. Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis. Journal of Natural Products. 69: 397-9. PMID 16562843 DOI: 10.1021/Np058070C |
0.623 |
|
| 2004 |
Wang X, Bastow KF, Sun CM, Lin YL, Yu HJ, Don MJ, Wu TS, Nakamura S, Lee KH. Antitumor Agents. 239. Isolation, structure elucidation, total synthesis, and anti-breast cancer activity of neo-tanshinlactone from Salvia miltiorrhiza. Journal of Medicinal Chemistry. 47: 5816-9. PMID 15509181 DOI: 10.1021/Jm040112R |
0.594 |
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| 2004 |
Wang YH, Hou AJ, Chen L, Chen DF, Sun HD, Zhao QS, Bastow KF, Nakanish Y, Wang XH, Lee KH. New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama. Journal of Natural Products. 67: 757-61. PMID 15165133 DOI: 10.1021/np030467y |
0.572 |
|
| 2004 |
Lee KH. Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads Journal of Natural Products. 67: 273-283. PMID 14987069 DOI: 10.1021/Np030373O |
0.328 |
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| 2003 |
Wu JH, Wang XH, Yi YH, Lee KH. Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos. Bioorganic & Medicinal Chemistry Letters. 13: 1813-5. PMID 12729671 DOI: 10.1016/S0960-894X(03)00197-5 |
0.548 |
|
| 2001 |
Shikishima Y, Takaishi Y, Honda G, Ito M, Takeda Y, Kodzhimatov OK, Ashurmetov O, Lee K. Chemical Constituents of Prangos tschimganica; Structure Elucidation and Absolute Configuration of Coumarin and Furanocoumarin Derivatives with Anti-HIV Activity Chemical & Pharmaceutical Bulletin. 49: 877-880. PMID 11456095 DOI: 10.1248/Cpb.49.877 |
0.454 |
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