Michael Paul Murphy - Publications

University of Kentucky University of Kentucky, Lexington, KY 
Alzheimer's disease

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN. The db mutation improves memory in younger mice in a model of Alzheimer's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 31034991 DOI: 10.1016/j.bbadis.2019.04.013  0.56
2018 Kim JH, Choi TG, Park S, Yun HR, Nguyen NNY, Jo YH, Jang M, Kim J, Kim J, Kang I, Ha J, Murphy MP, Tang DG, Kim SS. Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy. Cell Death and Differentiation. PMID 30042494 DOI: 10.1038/s41418-018-0165-9  0.32
2018 Xi Y, Feng D, Tao K, Wang R, Shi Y, Qin H, Murphy MP, Yang Q, Zhao G. MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α. Biochimica Et Biophysica Acta. PMID 29842922 DOI: 10.1016/j.bbadis.2018.05.018  0.32
2017 Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM. Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28559377 DOI: 10.1523/JNEUROSCI.0877-17.2017  0.56
2016 Lovell MA, Lynn BC, Fister S, Bradley-Whitman M, Murphy MP, Beckett TL, Norris CM. A Novel Small Molecule Modulator of Amyloid Pathology. Journal of Alzheimer's Disease : Jad. PMID 27163808 DOI: 10.3233/JAD-151160  0.8
2016 Platt TL, Beckett TL, Kohler K, Niedowicz DM, Murphy MP. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease Neuroscience. 315: 162-174. DOI: 10.1016/j.neuroscience.2015.12.011  0.8
2016 Murphy MP, Corriveau RA, Wilcock DM. Vascular contributions to cognitive impairment and dementia (VCID) Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1862: 857-859. DOI: 10.1016/j.bbadis.2016.02.010  0.8
2015 Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiology of Aging. 36: 2468-74. PMID 26103884 DOI: 10.1016/j.neurobiolaging.2015.05.016  0.8
2015 Tramutola A, Triplett JC, Di Domenico F, Niedowicz DM, Murphy MP, Coccia R, Perluigi M, Butterfield DA. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. Journal of Neurochemistry. 133: 739-49. PMID 25645581 DOI: 10.1111/jnc.13037  0.8
2015 Sethi M, Joshi SS, Webb RL, Beckett TL, Donohue KD, Murphy MP, O'Hara BF, Duncan MJ. Increased fragmentation of sleep-wake cycles in the 5XFAD mouse model of Alzheimer's disease. Neuroscience. 290: 80-9. PMID 25637807 DOI: 10.1016/j.neuroscience.2015.01.035  0.8
2015 Helman AM, Murphy MP. Vascular cognitive impairment: Modeling a critical neurologic disease in vitro and in vivo Biochimica Et Biophysica Acta - Molecular Basis of Disease. DOI: 10.1016/j.bbadis.2015.12.009  0.8
2014 Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. Journal of Alzheimer's Disease : Jad. 42: 1221-7. PMID 25024306 DOI: 10.3233/JAD-132450  0.8
2014 Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 42: 767-75. PMID 24927707 DOI: 10.3233/JAD-140795  0.8
2014 Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, ... ... Murphy MP, et al. Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathologica Communications. 2: 64. PMID 24916066 DOI: 10.1186/2051-5960-2-64  0.8
2014 Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TL, Murphy MP, Morley JE, Kumar V, Butterfield DA. Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radical Biology & Medicine. 67: 387-95. PMID 24355211 DOI: 10.1016/j.freeradbiomed.2013.11.014  0.8
2014 Bradley-Whitman MA, Timmons MD, Beckett TL, Murphy MP, Lynn BC, Lovell MA. Nucleic acid oxidation: an early feature of Alzheimer's disease. Journal of Neurochemistry. 128: 294-304. PMID 24032632 DOI: 10.1111/jnc.12444  0.8
2013 Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA. Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biology. 1: 80-5. PMID 24024140 DOI: 10.1016/j.redox.2013.01.002  0.56
2013 Dashdorj A, Jyothi KR, Lim S, Jo A, Nguyen MN, Ha J, Yoon KS, Kim HJ, Park JH, Murphy MP, Kim SS. Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. Bmc Medicine. 11: 178. PMID 23915129 DOI: 10.1186/1741-7015-11-178  0.32
2013 Murphy MP. Special issue: animal models of disease. Biochimica Et Biophysica Acta. 1832: 1361. PMID 23722202 DOI: 10.1016/j.bbadis.2013.05.024  0.8
2013 Platt TL, Reeves VL, Murphy MP. Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis. Biochimica Et Biophysica Acta. 1832: 1437-48. PMID 23619198 DOI: 10.1016/j.bbadis.2013.04.017  0.8
2013 Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochimica Et Biophysica Acta. 1832: 1249-59. PMID 23603808 DOI: 10.1016/j.bbadis.2013.04.013  0.8
2013 Amtul Z, Park JW, Murphy MP, Siddiqui RA, Choudhary MI. Dietary lipids and Alzheimer's disease. Current Alzheimer Research. 10: 542-8. PMID 23566347 DOI: 10.2174/1567205011310050010  0.8
2013 Beckett TL, Studzinski CM, Keller JN, Paul Murphy M, Niedowicz DM. A ketogenic diet improves motor performance but does not affect β-amyloid levels in a mouse model of Alzheimer's disease. Brain Research. 1505: 61-7. PMID 23415649 DOI: 10.1016/j.brainres.2013.01.046  0.36
2013 Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Freeman LR, Pepping JK, Beckett TL, Murphy MP, Keller JN. Prolonged diet induced obesity has minimal effects towards brain pathology in mouse model of cerebral amyloid angiopathy: implications for studying obesity-brain interactions in mice. Biochimica Et Biophysica Acta. 1832: 1456-62. PMID 23313575 DOI: 10.1016/j.bbadis.2013.01.002  0.8
2013 Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP. Leptin regulates amyloid β production via the γ-secretase complex. Biochimica Et Biophysica Acta. 1832: 439-44. PMID 23274884 DOI: 10.1016/j.bbadis.2012.12.009  0.8
2013 Pop V, Sorensen DW, Kamper JE, Ajao DO, Murphy MP, Head E, Hartman RE, Badaut J. Early brain injury alters the blood-brain barrier phenotype in parallel with β-amyloid and cognitive changes in adulthood. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 205-14. PMID 23149553 DOI: 10.1038/jcbfm.2012.154  0.36
2013 Holler CJ, Murphy MP. BACE1: Expression, regulation, and therapeutic potential of the major Alzheimer's disease beta-Secretase Current Enzyme Inhibition. 9: 3-14. DOI: 10.2174/1573408011309010003  0.8
2012 Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM. Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16129-40. PMID 23152597 DOI: 10.1523/JNEUROSCI.2323-12.2012  0.8
2012 Niedowicz DM, Beckett TL, Matveev S, Weidner AM, Baig I, Kryscio RJ, Mendiondo MS, LeVine H, Keller JN, Murphy MP. Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease. Annals of Neurology. 72: 564-70. PMID 23109151 DOI: 10.1002/ana.23633  0.8
2012 Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. 17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 153: 5467-79. PMID 22962256 DOI: 10.1210/en.2012-1464  0.8
2012 Head E, Murphey HL, Dowling AL, McCarty KL, Bethel SR, Nitz JA, Pleiss M, Vanrooyen J, Grossheim M, Smiley JR, Murphy MP, Beckett TL, Pagani D, Bresch F, Hendrix C. A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 32: 1029-42. PMID 22886019 DOI: 10.3233/JAD-2012-120937  0.8
2012 Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H, Keller JN, Murphy MP. Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression. Journal of Alzheimer's Disease : Jad. 32: 127-38. PMID 22766739 DOI: 10.3233/JAD-2012-120655  0.8
2012 Duncan MJ, Smith JT, Franklin KM, Beckett TL, Murphy MP, St Clair DK, Donohue KD, Striz M, O'Hara BF. Effects of aging and genotype on circadian rhythms, sleep, and clock gene expression in APPxPS1 knock-in mice, a model for Alzheimer's disease. Experimental Neurology. 236: 249-58. PMID 22634208 DOI: 10.1016/j.expneurol.2012.05.011  0.8
2012 Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 30: 943-61. PMID 22495349 DOI: 10.3233/JAD-2012-111661  0.8
2012 Webb RL, Murphy MP. β-Secretases, Alzheimer's Disease, and Down Syndrome. Current Gerontology and Geriatrics Research. 2012: 362839. PMID 22481915 DOI: 10.1155/2012/362839  0.8
2012 Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50. PMID 22074738 DOI: 10.1016/j.ajpath.2011.09.034  0.8
2012 Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochimica Et Biophysica Acta. 1822: 130-8. PMID 22009041 DOI: 10.1016/j.bbadis.2011.10.001  0.8
2012 Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. Journal of Neurochemistry. 120: 135-46. PMID 22004509 DOI: 10.1111/j.1471-4159.2011.07538.x  0.8
2012 Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 981-7. PMID 21767440 DOI: 10.1017/S1461145711001118  0.8
2012 Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiology of Aging. 33: 108-20. PMID 20434811 DOI: 10.1016/j.neurobiolaging.2010.02.008  0.8
2011 Lim S, Rashid MA, Jang M, Kim Y, Won H, Lee J, Woo JT, Kim YS, Murphy MP, Ali L, Ha J, Kim SS. Mitochondria-targeted antioxidants protect pancreatic β-cells against oxidative stress and improve insulin secretion in glucotoxicity and glucolipotoxicity. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 28: 873-86. PMID 22178940 DOI: 10.1159/000335802  0.32
2011 Weidner AM, Bradley MA, Beckett TL, Niedowicz DM, Dowling AL, Matveev SV, LeVine H, Lovell MA, Murphy MP. RNA oxidation adducts 8-OHG and 8-OHA change with Aβ42 levels in late-stage Alzheimer's disease. Plos One. 6: e24930. PMID 21949792 DOI: 10.1371/journal.pone.0024930  0.8
2011 Bruce-Keller AJ, Gupta S, Knight AG, Beckett TL, McMullen JM, Davis PR, Murphy MP, Van Eldik LJ, St Clair D, Keller JN. Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. Neurobiology of Disease. 44: 317-26. PMID 21798347 DOI: 10.1016/j.nbd.2011.07.012  0.8
2011 Martin SB, Cenini G, Barone E, Dowling AL, Mancuso C, Butterfield DA, Murphy MP, Head E. Coenzyme Q10 and cognition in atorvastatin treated dogs. Neuroscience Letters. 501: 92-5. PMID 21763754 DOI: 10.1016/j.neulet.2011.06.054  0.8
2011 Weidner AM, Housley M, Murphy MP, Levine H. Purified high molecular weight synthetic Aβ(1-42) and biological Aβ oligomers are equipotent in rapidly inducing MTT formazan exocytosis. Neuroscience Letters. 497: 1-5. PMID 21504780 DOI: 10.1016/j.neulet.2011.03.082  0.8
2011 Lee S, Tak E, Lee J, Rashid MA, Murphy MP, Ha J, Kim SS. Mitochondrial H2O2 generated from electron transport chain complex I stimulates muscle differentiation. Cell Research. 21: 817-34. PMID 21445095 DOI: 10.1038/cr.2011.55  0.32
2011 Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 172-80. PMID 21193043 DOI: 10.1016/j.phrs.2010.12.007  0.8
2011 Murphy MP, Head E. Impact of Aging on Brain Structure and Function in Rodents and Canines Fundamental Neuropathology For Pathologists and Toxicologists: Principles and Techniques. 125-138. DOI: 10.1002/9780470939956.ch8  0.8
2010 Ebenezer PJ, Weidner AM, LeVine H, Markesbery WR, Murphy MP, Zhang L, Dasuri K, Fernandez-Kim SO, Bruce-Keller AJ, Gavilán E, Keller JN. Neuron specific toxicity of oligomeric amyloid-β: role for JUN-kinase and oxidative stress. Journal of Alzheimer's Disease : Jad. 22: 839-48. PMID 20858948 DOI: 10.3233/JAD-2010-101161  0.8
2010 Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Journal of Alzheimer's Disease : Jad. 22: 135-50. PMID 20847439 DOI: 10.3233/JAD-2010-100639  0.8
2010 Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9831-9. PMID 20660265 DOI: 10.1523/JNEUROSCI.6194-09.2010  0.8
2010 Niedowicz DM, Beckett TL, Holler CJ, Weidner AM, Murphy MP. APP(DeltaNL695) expression in murine tissue downregulates CNBP expression. Neuroscience Letters. 482: 57-61. PMID 20621159 DOI: 10.1016/j.neulet.2010.07.006  0.8
2010 Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB. Circulating neprilysin clears brain amyloid. Molecular and Cellular Neurosciences. 45: 101-7. PMID 20558294 DOI: 10.1016/j.mcn.2010.05.014  0.8
2010 Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, LeVine H, Murphy MP. Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle. Neurobiology of Disease. 39: 449-56. PMID 20493261 DOI: 10.1016/j.nbd.2010.05.018  0.8
2010 Aluise CD, Robinson RA, Beckett TL, Murphy MP, Cai J, Pierce WM, Markesbery WR, Butterfield DA. Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics. Neurobiology of Disease. 39: 221-8. PMID 20399861 DOI: 10.1016/j.nbd.2010.04.011  0.8
2010 Webb RL, Findlay KA, Green MA, Beckett TL, Murphy MP. Efficient activation of reconstructed rat embryos by cyclin-dependent kinase inhibitors. Plos One. 5: e9799. PMID 20333307 DOI: 10.1371/journal.pone.0009799  0.8
2010 Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease : Jad. 20: 637-46. PMID 20164551 DOI: 10.3233/JAD-2010-1397  0.8
2010 Bader Lange ML, St Clair D, Markesbery WR, Studzinski CM, Murphy MP, Butterfield DA. Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease. Neurobiology of Disease. 38: 104-15. PMID 20083199 DOI: 10.1016/j.nbd.2010.01.004  0.8
2010 Murphy MP, LeVine H. Alzheimer's disease and the amyloid-beta peptide. Journal of Alzheimer's Disease : Jad. 19: 311-23. PMID 20061647 DOI: 10.3233/JAD-2010-1221  0.8
2010 Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. Journal of Neurochemistry. 112: 1045-53. PMID 19968762 DOI: 10.1111/j.1471-4159.2009.06528.x  0.8
2010 Eriksen JL, Murphy MP, Head E. Pharmacological Models for Preclinical Testing: From Mouse to Dog to Nonhuman Primates Bace: Lead Target For Orchestrated Therapy of Alzheimer's Disease. 159-175. DOI: 10.1002/9780470594087.ch7  0.8
2009 Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H, Kraner SD, Norris CM. Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12957-69. PMID 19828810 DOI: 10.1523/JNEUROSCI.1064-09.2009  0.8
2009 Walters GD, Berry DT, Lanyon RI, Murphy MP. Are exaggerated health complaints continuous or categorical? A taxometric analysis of the Health Problem Overstatement Scale. Psychological Assessment. 21: 219-26. PMID 19485676 DOI: 10.1037/a0015306  0.8
2009 Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, Klein R, Hersh LB. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1381-6. PMID 19471248 DOI: 10.1038/mt.2009.115  0.8
2009 Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-DeMotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA. Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. Journal of Alzheimer's Disease : Jad. 17: 553-70. PMID 19433890 DOI: 10.3233/JAD-2009-1074  0.8
2009 Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN. Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice. Journal of Neurochemistry. 108: 860-6. PMID 19046405 DOI: 10.1111/j.1471-4159.2008.05798.x  0.8
2009 Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. Journal of Neuroscience Research. 87: 1462-73. PMID 19021293 DOI: 10.1002/jnr.21944  0.8
2008 Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM. Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Research. 1226: 209-17. PMID 18582445 DOI: 10.1016/j.brainres.2008.06.005  0.8
2008 Pike CJ, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER. Androgen cell signaling pathways involved in neuroprotective actions. Hormones and Behavior. 53: 693-705. PMID 18222446 DOI: 10.1016/j.yhbeh.2007.11.006  0.8
2007 Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Disease and Associated Disorders. 21: 292-9. PMID 18090435 DOI: 10.1097/WAD.0b013e31815d1048  0.8
2007 Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB. In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides. 28: 2348-55. PMID 17988763 DOI: 10.1016/j.peptides.2007.09.015  0.8
2007 Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H, Keller JN. Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiology of Disease. 27: 301-11. PMID 17651976 DOI: 10.1016/j.nbd.2007.06.002  0.8
2007 Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. Bmc Neuroscience. 8: 54. PMID 17650315 DOI: 10.1186/1471-2202-8-54  0.8
2006 Anantharaman M, Tangpong J, Keller JN, Murphy MP, Markesbery WR, Kiningham KK, St Clair DK. Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. The American Journal of Pathology. 168: 1608-18. PMID 16651627 DOI: 10.2353/ajpath.2006.051223  0.8
2006 Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/j.vaccine.2005.12.058  0.8
2006 Murphy MP, Golde TE. Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether? Neurology. 66: S65-8. PMID 16432148 DOI: 10.1212/01.wnl.0000192108.02654.ac  0.8
2006 Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 116: 193-201. PMID 16341263 DOI: 10.1172/JCI25410  0.8
2005 McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47: 191-9. PMID 16039562 DOI: 10.1016/j.neuron.2005.06.030  0.8
2005 Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature Medicine. 11: 545-50. PMID 15834426 DOI: 10.1038/nm1235  0.8
2005 Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging. 26: 749-63. PMID 15708450 DOI: 10.1016/j.neurobiolaging.2004.06.015  0.8
2004 Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochemical and Biophysical Research Communications. 322: 1145-52. PMID 15336962 DOI: 10.1016/j.bbrc.2004.07.136  0.8
2003 Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ. Androgens modulate beta-amyloid levels in male rat brain. Journal of Neurochemistry. 87: 1052-5. PMID 14622134 DOI: 10.1046/j.1471-4159.2003.02114.x  0.8
2003 Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8532-8. PMID 13679422  0.8
2003 Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39: 409-21. PMID 12895417 DOI: 10.1016/S0896-6273(03)00434-3  0.8
2003 Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Peptide-based, irreversible inhibitors of gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 529-33. PMID 12763025 DOI: 10.1016/S0006-291X(03)00828-3  0.8
2003 Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Overexpression of nicastrin increases Abeta production. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1138-40. PMID 12692078 DOI: 10.1096/fj.02-1050fje  0.8
2002 Rochette MJ, Murphy MP. γ-Secretase: Substrates and inhibitors Molecular Neurobiology. 26: 81-95. PMID 12392058  0.8
2002 Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 99: 6334-9. PMID 11972038 DOI: 10.1073/pnas.082545599  0.8
2002 Murphy MP, Uljon SN, Golde TE, Wang R. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants. Biochimica Et Biophysica Acta. 1586: 199-209. PMID 11959461 DOI: 10.1016/S0925-4439(01)00098-9  0.8
2002 Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America. 99: 4697-702. PMID 11917117 DOI: 10.1073/pnas.072033799  0.8
2001 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiology of Aging. 22: 721-7. PMID 11705631 DOI: 10.1016/S0197-4580(01)00245-7  0.8
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  0.8
2001 Ni CY, Murphy MP, Golde TE, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (New York, N.Y.). 294: 2179-81. PMID 11679632 DOI: 10.1126/science.1065412  0.6
2001 Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. The Journal of Biological Chemistry. 276: 38563-9. PMID 11504726 DOI: 10.1074/jbc.M105376200  0.8
2001 Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE. Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochimica Et Biophysica Acta. 1537: 58-62. PMID 11476963 DOI: 10.1016/S0925-4439(01)00054-0  0.8
2001 Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C, Killick R, Iqbal T, Raymond L, Varndell I, Sheppard P, Makoff A, Gower E, Soden PE, Lewis P, ... Murphy M, et al. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4987-95. PMID 11438574  0.8
2000 Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. An empirical model of gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 233-40. PMID 11193156 DOI: 10.1111/j.1749-6632.2000.tb06928.x  0.8
2000 McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. Cell-free assays for gamma-secretase activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2383-6. PMID 11024004 DOI: 10.1096/fj.00-0286fje  0.8
2000 Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genetics. 25: 402-5. PMID 10932182 DOI: 10.1038/78078  0.8
2000 Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. The Journal of Biological Chemistry. 275: 26277-84. PMID 10816583 DOI: 10.1074/jbc.M002812200  0.8
1999 Murphy MP, Hickman LJ, Eckman CB, Uljon SN, Wang R, Golde TE. gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length. The Journal of Biological Chemistry. 274: 11914-23. PMID 10207012 DOI: 10.1074/jbc.274.17.11914  0.8
1997 Cammisuli S, Murphy MP, Ikeda-Douglas CJ, Balkissoon V, Holsinger RM, Head E, Michael M, Racine RJ, Milgram NW. Effects of extended electrical kindling on exploratory behavior and spatial learning. Behavioural Brain Research. 89: 179-90. PMID 9475625 DOI: 10.1016/S0166-4328(97)00059-4  0.8
1997 Mielke JG, Murphy MP, Maritz J, Bengualid KM, O. Ivy G. Chloroquine administration in mice increases β-amyloid immunoreactivity and attenuates kainate-induced blood-brain barrier dysfunction Neuroscience Letters. 227: 169-172. PMID 9185677 DOI: 10.1016/S0304-3940(97)00340-6  0.8
1996 Rick JT, Murphy MP, Ivy GO, Milgram NW. Short intertrial intervals impair water maze performance in old Fischer 344 rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 51: B253-60. PMID 8680989 DOI: 10.1093/gerona/51A.4.B253  0.8
1995 Milgram NW, Ivy GO, Murphy MP, Head E, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Boulton AA. Effects of chronic oral administration of L-deprenyl in the dog. Pharmacology, Biochemistry, and Behavior. 51: 421-8. PMID 7667363 DOI: 10.1016/0091-3057(94)00417-H  0.8
1995 Murphy MP, Rick JT, Milgram NW, Ivy GO. A simple and rapid test of sensorimotor function in the aged rat. Neurobiology of Learning and Memory. 64: 181-6. PMID 7582826 DOI: 10.1006/nlme.1995.1057  0.8
1994 Ivy GO, Rick JT, Murphy MP, Head E, Reid C, Milgram NW. Effects of L-deprenyl on manifestations of aging in the rat and dog. Annals of the New York Academy of Sciences. 717: 45-59. PMID 8030851 DOI: 10.1111/j.1749-6632.1994.tb12072.x  0.8
1993 Murphy MP, Wu PH, Milgram NW, Ivy GO. Monoamine oxidase inhibition by L-deprenyl depends on both sex and route of administration in the rat. Neurochemical Research. 18: 1299-304. PMID 8272194 DOI: 10.1007/BF00975051  0.8
1993 Milgram NW, Ivy GO, Head E, Murphy MP, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Paterson IA. The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog. Neurochemical Research. 18: 1211-9. PMID 8272186 DOI: 10.1007/BF00975038  0.8
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