Michael Paul Murphy - Publications

University of Kentucky University of Kentucky, Lexington, KY 
Alzheimer's disease

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Womack TR, Vollert CT, Ohia-Nwoko O, Schmitt M, Montazari S, Beckett TL, Mayerich D, Murphy MP, Eriksen JL. Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer's Disease. Frontiers in Cellular Neuroscience. 16: 769347. PMID 35197825 DOI: 10.3389/fncel.2022.769347  0.418
2019 Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN. The db mutation improves memory in younger mice in a model of Alzheimer's disease. Biochimica Et Biophysica Acta. Molecular Basis of Disease. PMID 31034991 DOI: 10.1016/J.Bbadis.2019.04.013  0.328
2018 Ma D, Wang AC, Parikh I, Green SJ, Hoffman JD, Chlipala G, Murphy MP, Sokola BS, Bauer B, Hartz AMS, Lin AL. Ketogenic diet enhances neurovascular function with altered gut microbiome in young healthy mice. Scientific Reports. 8: 6670. PMID 29703936 DOI: 10.1038/S41598-018-25190-5  0.311
2017 Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM. Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28559377 DOI: 10.1523/Jneurosci.0877-17.2017  0.3
2016 Lovell MA, Lynn BC, Fister S, Bradley-Whitman M, Murphy MP, Beckett TL, Norris CM. A Novel Small Molecule Modulator of Amyloid Pathology. Journal of Alzheimer's Disease : Jad. PMID 27163808 DOI: 10.3233/Jad-151160  0.386
2015 Wilcock DM, Hurban J, Helman AM, Sudduth TL, McCarty KL, Beckett TL, Ferrell JC, Murphy MP, Abner EL, Schmitt FA, Head E. Down syndrome individuals with Alzheimer's disease have a distinct neuroinflammatory phenotype compared to sporadic Alzheimer's disease. Neurobiology of Aging. 36: 2468-74. PMID 26103884 DOI: 10.1016/J.Neurobiolaging.2015.05.016  0.332
2015 Tramutola A, Triplett JC, Di Domenico F, Niedowicz DM, Murphy MP, Coccia R, Perluigi M, Butterfield DA. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD. Journal of Neurochemistry. 133: 739-49. PMID 25645581 DOI: 10.1111/Jnc.13037  0.367
2014 Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP. Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology. Journal of Alzheimer's Disease : Jad. 42: 1221-7. PMID 25024306 DOI: 10.3233/Jad-132450  0.793
2014 Martin SB, Dowling AL, Lianekhammy J, Lott IT, Doran E, Murphy MP, Beckett TL, Schmitt FA, Head E. Synaptophysin and synaptojanin-1 in Down syndrome are differentially affected by Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 42: 767-75. PMID 24927707 DOI: 10.3233/Jad-140795  0.378
2014 Farr SA, Ripley JL, Sultana R, Zhang Z, Niehoff ML, Platt TL, Murphy MP, Morley JE, Kumar V, Butterfield DA. Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease. Free Radical Biology & Medicine. 67: 387-95. PMID 24355211 DOI: 10.1016/J.Freeradbiomed.2013.11.014  0.325
2014 Bradley-Whitman MA, Timmons MD, Beckett TL, Murphy MP, Lynn BC, Lovell MA. Nucleic acid oxidation: an early feature of Alzheimer's disease. Journal of Neurochemistry. 128: 294-304. PMID 24032632 DOI: 10.1111/Jnc.12444  0.304
2013 Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA. Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biology. 1: 80-5. PMID 24024140 DOI: 10.1016/J.Redox.2013.01.002  0.425
2013 Platt TL, Reeves VL, Murphy MP. Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis. Biochimica Et Biophysica Acta. 1832: 1437-48. PMID 23619198 DOI: 10.1016/J.Bbadis.2013.04.017  0.312
2013 Di Domenico F, Coccia R, Cocciolo A, Murphy MP, Cenini G, Head E, Butterfield DA, Giorgi A, Schinina ME, Mancuso C, Cini C, Perluigi M. Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochimica Et Biophysica Acta. 1832: 1249-59. PMID 23603808 DOI: 10.1016/J.Bbadis.2013.04.013  0.337
2013 Niedowicz DM, Studzinski CM, Weidner AM, Platt TL, Kingry KN, Beckett TL, Bruce-Keller AJ, Keller JN, Murphy MP. Leptin regulates amyloid β production via the γ-secretase complex. Biochimica Et Biophysica Acta. 1832: 439-44. PMID 23274884 DOI: 10.1016/J.Bbadis.2012.12.009  0.794
2013 Holler CJ, Murphy MP. BACE1: Expression, regulation, and therapeutic potential of the major Alzheimer's disease beta-Secretase Current Enzyme Inhibition. 9: 3-14. DOI: 10.2174/1573408011309010003  0.766
2012 Furman JL, Sama DM, Gant JC, Beckett TL, Murphy MP, Bachstetter AD, Van Eldik LJ, Norris CM. Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16129-40. PMID 23152597 DOI: 10.1523/Jneurosci.2323-12.2012  0.375
2012 Niedowicz DM, Beckett TL, Matveev S, Weidner AM, Baig I, Kryscio RJ, Mendiondo MS, LeVine H, Keller JN, Murphy MP. Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease. Annals of Neurology. 72: 564-70. PMID 23109151 DOI: 10.1002/Ana.23633  0.364
2012 Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H, Keller JN, Murphy MP. Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression. Journal of Alzheimer's Disease : Jad. 32: 127-38. PMID 22766739 DOI: 10.3233/Jad-2012-120655  0.793
2012 Searcy JL, Phelps JT, Pancani T, Kadish I, Popovic J, Anderson KL, Beckett TL, Murphy MP, Chen KC, Blalock EM, Landfield PW, Porter NM, Thibault O. Long-term pioglitazone treatment improves learning and attenuates pathological markers in a mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 30: 943-61. PMID 22495349 DOI: 10.3233/Jad-2012-111661  0.37
2012 Webb RL, Murphy MP. β-Secretases, Alzheimer's Disease, and Down Syndrome. Current Gerontology and Geriatrics Research. 2012: 362839. PMID 22481915 DOI: 10.1155/2012/362839  0.415
2012 Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50. PMID 22074738 DOI: 10.1016/J.Ajpath.2011.09.034  0.795
2012 Cenini G, Dowling AL, Beckett TL, Barone E, Mancuso C, Murphy MP, Levine H, Lott IT, Schmitt FA, Butterfield DA, Head E. Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochimica Et Biophysica Acta. 1822: 130-8. PMID 22009041 DOI: 10.1016/J.Bbadis.2011.10.001  0.346
2012 Barone E, Mancuso C, Di Domenico F, Sultana R, Murphy MP, Head E, Butterfield DA. Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. Journal of Neurochemistry. 120: 135-46. PMID 22004509 DOI: 10.1111/J.1471-4159.2011.07538.X  0.315
2012 Butterfield DA, Barone E, Di Domenico F, Cenini G, Sultana R, Murphy MP, Mancuso C, Head E. Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 981-7. PMID 21767440 DOI: 10.1017/S1461145711001118  0.32
2012 Pop V, Head E, Berchtold NC, Glabe CG, Studzinski CM, Weidner AM, Murphy MP, Cotman CW. Aβ aggregation profiles and shifts in APP processing favor amyloidogenesis in canines. Neurobiology of Aging. 33: 108-20. PMID 20434811 DOI: 10.1016/J.Neurobiolaging.2010.02.008  0.767
2011 McManus MJ, Murphy MP, Franklin JL. The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15703-15. PMID 22049413 DOI: 10.1523/JNEUROSCI.0552-11.2011  0.351
2011 Barone E, Cenini G, Di Domenico F, Martin S, Sultana R, Mancuso C, Murphy MP, Head E, Butterfield DA. Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 172-80. PMID 21193043 DOI: 10.1016/J.Phrs.2010.12.007  0.312
2010 Murphy MP, Morales J, Beckett TL, Astarita G, Piomelli D, Weidner A, Studzinski CM, Dowling AL, Wang X, Levine H, Kryscio RJ, Lin Y, Barrett E, Head E. Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs. Journal of Alzheimer's Disease : Jad. 22: 135-50. PMID 20847439 DOI: 10.3233/Jad-2010-100639  0.748
2010 Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9831-9. PMID 20660265 DOI: 10.1523/Jneurosci.6194-09.2010  0.411
2010 Niedowicz DM, Beckett TL, Holler CJ, Weidner AM, Murphy MP. APP(DeltaNL695) expression in murine tissue downregulates CNBP expression. Neuroscience Letters. 482: 57-61. PMID 20621159 DOI: 10.1016/J.Neulet.2010.07.006  0.783
2010 Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB. Circulating neprilysin clears brain amyloid. Molecular and Cellular Neurosciences. 45: 101-7. PMID 20558294 DOI: 10.1016/J.Mcn.2010.05.014  0.788
2010 Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, LeVine H, Murphy MP. Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle. Neurobiology of Disease. 39: 449-56. PMID 20493261 DOI: 10.1016/J.Nbd.2010.05.018  0.807
2010 Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, Reddy PH. Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. Journal of Alzheimer's Disease : Jad. 20: S609-31. PMID 20463406 DOI: 10.3233/JAD-2010-100564  0.413
2010 Aluise CD, Robinson RA, Beckett TL, Murphy MP, Cai J, Pierce WM, Markesbery WR, Butterfield DA. Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics. Neurobiology of Disease. 39: 221-8. PMID 20399861 DOI: 10.1016/J.Nbd.2010.04.011  0.418
2010 Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease : Jad. 20: 637-46. PMID 20164551 DOI: 10.3233/Jad-2010-1397  0.817
2010 Bader Lange ML, St Clair D, Markesbery WR, Studzinski CM, Murphy MP, Butterfield DA. Age-related loss of phospholipid asymmetry in APP(NLh)/APP(NLh) x PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice: relevance to Alzheimer disease. Neurobiology of Disease. 38: 104-15. PMID 20083199 DOI: 10.1016/J.Nbd.2010.01.004  0.8
2010 Murphy MP, LeVine H. Alzheimer's disease and the amyloid-beta peptide. Journal of Alzheimer's Disease : Jad. 19: 311-23. PMID 20061647 DOI: 10.3233/JAD-2010-1221  0.475
2010 Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP. BACE1 and BACE2 enzymatic activities in Alzheimer's disease. Journal of Neurochemistry. 112: 1045-53. PMID 19968762 DOI: 10.1111/J.1471-4159.2009.06528.X  0.822
2010 Hersh LB, Studzinski C, Beckett T, Murphy MP, Klein RL, Liu Y. P3-414: Peripheral expression of neprilysin leads to clearance of brain Abeta Alzheimer's & Dementia. 6: S574-S574. DOI: 10.1016/J.Jalz.2010.05.1957  0.766
2009 Abdul HM, Sama MA, Furman JL, Mathis DM, Beckett TL, Weidner AM, Patel ES, Baig I, Murphy MP, LeVine H, Kraner SD, Norris CM. Cognitive decline in Alzheimer's disease is associated with selective changes in calcineurin/NFAT signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12957-69. PMID 19828810 DOI: 10.1523/Jneurosci.1064-09.2009  0.374
2009 Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, Klein R, Hersh LB. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1381-6. PMID 19471248 DOI: 10.1038/Mt.2009.115  0.809
2009 Jaeger LB, Dohgu S, Hwang MC, Farr SA, Murphy MP, Fleegal-DeMotta MA, Lynch JL, Robinson SM, Niehoff ML, Johnson SN, Kumar VB, Banks WA. Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. Journal of Alzheimer's Disease : Jad. 17: 553-70. PMID 19433890 DOI: 10.3233/JAD-2009-1074  0.449
2009 Studzinski CM, Li F, Bruce-Keller AJ, Fernandez-Kim SO, Zhang L, Weidner AM, Markesbery WR, Murphy MP, Keller JN. Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice. Journal of Neurochemistry. 108: 860-6. PMID 19046405 DOI: 10.1111/J.1471-4159.2008.05798.X  0.782
2009 Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. Journal of Neuroscience Research. 87: 1462-73. PMID 19021293 DOI: 10.1002/Jnr.21944  0.47
2008 Studzinski CM, MacKay WA, Beckett TL, Henderson ST, Murphy MP, Sullivan PG, Burnham WM. Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog. Brain Research. 1226: 209-17. PMID 18582445 DOI: 10.1016/J.Brainres.2008.06.005  0.806
2008 Pike CJ, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER. Androgen cell signaling pathways involved in neuroprotective actions. Hormones and Behavior. 53: 693-705. PMID 18222446 DOI: 10.1016/J.Yhbeh.2007.11.006  0.359
2007 Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Disease and Associated Disorders. 21: 292-9. PMID 18090435 DOI: 10.1097/Wad.0B013E31815D1048  0.568
2007 Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB. In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides. 28: 2348-55. PMID 17988763 DOI: 10.1016/J.Peptides.2007.09.015  0.429
2007 Murphy MP, Beckett TL, Ding Q, Patel E, Markesbery WR, St Clair DK, LeVine H, Keller JN. Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiology of Disease. 27: 301-11. PMID 17651976 DOI: 10.1016/J.Nbd.2007.06.002  0.464
2007 Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. Bmc Neuroscience. 8: 54. PMID 17650315 DOI: 10.1186/1471-2202-8-54  0.6
2007 Ahmed RR, Murphy MP, Rochette MJ, Golde TE. Beta‐secretase regulation in aging and disease The Faseb Journal. 21. DOI: 10.1096/fasebj.21.5.a278-b  0.456
2006 Anantharaman M, Tangpong J, Keller JN, Murphy MP, Markesbery WR, Kiningham KK, St Clair DK. Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. The American Journal of Pathology. 168: 1608-18. PMID 16651627 DOI: 10.2353/ajpath.2006.051223  0.433
2006 Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/J.Vaccine.2005.12.058  0.375
2006 Murphy MP, Golde TE. Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether? Neurology. 66: S65-8. PMID 16432148 DOI: 10.1212/01.wnl.0000192108.02654.ac  0.507
2006 Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 116: 193-201. PMID 16341263 DOI: 10.1172/Jci25410  0.682
2006 Rosen RF, LeVine H, Murphy M, Preuss TM, Ghiso JA, Farberg A, Gearing M, Walker LC. P2-005: Patterns of Aβ accumulation in Alzheimer's and aged primate brain Alzheimer's & Dementia. 2: S233-S233. DOI: 10.1016/J.Jalz.2006.05.842  0.35
2005 McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47: 191-9. PMID 16039562 DOI: 10.1016/J.Neuron.2005.06.030  0.668
2005 Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature Medicine. 11: 545-50. PMID 15834426 DOI: 10.1038/Nm1235  0.675
2005 Head E, Moffat K, Das P, Sarsoza F, Poon WW, Landsberg G, Cotman CW, Murphy MP. Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats. Neurobiology of Aging. 26: 749-63. PMID 15708450 DOI: 10.1016/J.Neurobiolaging.2004.06.015  0.527
2004 Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochemical and Biophysical Research Communications. 322: 1145-52. PMID 15336962 DOI: 10.1016/J.Bbrc.2004.07.136  0.419
2003 Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ. Androgens modulate beta-amyloid levels in male rat brain. Journal of Neurochemistry. 87: 1052-5. PMID 14622134 DOI: 10.1046/J.1471-4159.2003.02114.X  0.643
2003 Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8532-8. PMID 13679422  0.632
2003 Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39: 409-21. PMID 12895417 DOI: 10.1016/S0896-6273(03)00434-3  0.638
2003 Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Peptide-based, irreversible inhibitors of gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 529-33. PMID 12763025 DOI: 10.1016/S0006-291X(03)00828-3  0.526
2003 Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Overexpression of nicastrin increases Abeta production. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1138-40. PMID 12692078 DOI: 10.1096/fj.02-1050fje  0.604
2003 Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/-Knock-Out Mice The Journal of Neuroscience. 23: 8532-8538. DOI: 10.1523/Jneurosci.23-24-08532.2003  0.584
2002 Rochette MJ, Murphy MP. γ-Secretase: Substrates and inhibitors Molecular Neurobiology. 26: 81-95. PMID 12392058  0.414
2002 Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 99: 6334-9. PMID 11972038 DOI: 10.1073/Pnas.082545599  0.575
2002 Murphy MP, Uljon SN, Golde TE, Wang R. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants. Biochimica Et Biophysica Acta. 1586: 199-209. PMID 11959461 DOI: 10.1016/S0925-4439(01)00098-9  0.585
2002 Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America. 99: 4697-702. PMID 11917117 DOI: 10.1073/Pnas.072033799  0.489
2001 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiology of Aging. 22: 721-7. PMID 11705631 DOI: 10.1016/S0197-4580(01)00245-7  0.627
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  0.705
2001 Ni CY, Murphy MP, Golde TE, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (New York, N.Y.). 294: 2179-81. PMID 11679632 DOI: 10.1126/Science.1065412  0.403
2001 Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. The Journal of Biological Chemistry. 276: 38563-9. PMID 11504726 DOI: 10.1074/Jbc.M105376200  0.478
2001 Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE. Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochimica Et Biophysica Acta. 1537: 58-62. PMID 11476963 DOI: 10.1016/S0925-4439(01)00054-0  0.661
2001 Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C, Killick R, Iqbal T, Raymond L, Varndell I, Sheppard P, Makoff A, Gower E, Soden PE, Lewis P, ... Murphy M, et al. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4987-95. PMID 11438574 DOI: 10.1523/Jneurosci.21-14-04987.2001  0.562
2000 Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. An empirical model of gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 233-40. PMID 11193156 DOI: 10.1111/J.1749-6632.2000.Tb06928.X  0.611
2000 McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. Cell-free assays for gamma-secretase activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2383-6. PMID 11024004 DOI: 10.1096/Fj.00-0286Fje  0.586
2000 Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. The Journal of Biological Chemistry. 275: 26277-84. PMID 10816583 DOI: 10.1074/Jbc.M002812200  0.583
2000 Golde TE, Findlay KA, Smith TE, Thompson S, McLendon DC, Wang R, Murphy MP. Presenilns regulators of γ-secretase cleavage Neurobiology of Aging. 21: 67. DOI: 10.1016/S0197-4580(00)82523-3  0.492
2000 Murphy MP, McLendon DC, Findlay KA, Smith TE, Ziani-Cherif C, Fauq A. Molecular targets for the inhibition of Aβ production Neurobiology of Aging. 21: 180. DOI: 10.1016/S0197-4580(00)82147-8  0.309
2000 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Aβ42 deposition is selectively altered in brains of Aβ1–42 immunized TG2576 mice Neurobiology of Aging. 21: 152-153. DOI: 10.1016/S0197-4580(00)82023-0  0.592
1999 Murphy MP, Hickman LJ, Eckman CB, Uljon SN, Wang R, Golde TE. gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length. The Journal of Biological Chemistry. 274: 11914-23. PMID 10207012 DOI: 10.1074/Jbc.274.17.11914  0.614
1997 Mielke JG, Murphy MP, Maritz J, Bengualid KM, O. Ivy G. Chloroquine administration in mice increases β-amyloid immunoreactivity and attenuates kainate-induced blood-brain barrier dysfunction Neuroscience Letters. 227: 169-172. PMID 9185677 DOI: 10.1016/S0304-3940(97)00340-6  0.437
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