Kivanc birsoy - Publications

Affiliations: 
Whitehead Institute, Cambridge, MA, United States 

63/87 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Timson RC, Khan A, Uygur B, Saad M, Yeh HW, DelGaudio NL, Weber R, Alwaseem H, Gao J, Yang C, Birsoy K. Development of a mouse model expressing a bifunctional glutathione synthesizing enzyme to study glutathione limitation in vivo. The Journal of Biological Chemistry. 105645. PMID 38218225 DOI: 10.1016/j.jbc.2024.105645  0.316
2022 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. Author Correction: NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 609: E12. PMID 36104569 DOI: 10.1038/s41586-022-05323-7  0.433
2022 Garcia-Bermudez J, Badgley MA, Prasad S, Baudrier L, Liu Y, La K, Soula M, Williams RT, Yamaguchi N, Hwang RF, Taylor LJ, de Stanchina E, Rostandy B, Alwaseem H, Molina H, ... ... Birsoy K, et al. Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia. Nature Metabolism. PMID 35726024 DOI: 10.1038/s42255-022-00583-z  0.309
2020 Parsa S, Ortega-Molina A, Ying HY, Jiang M, Teater M, Wang J, Zhao C, Reznik E, Pasion JP, Kuo D, Mohan P, Wang S, Camarillo JM, Thomas PM, Jain N, ... ... Birsoy K, et al. The serine hydroxymethyltransferase-2 (SHMT2) initiates lymphoma development through epigenetic tumor suppressor silencing. Nature Cancer. 1: 653-664. PMID 33569544 DOI: 10.1038/s43018-020-0080-0  0.43
2020 Zhu XG, Chudnovskiy A, Baudrier L, Prizer B, Liu Y, Ostendorf BN, Yamaguchi N, Arab A, Tavora B, Timson R, Heissel S, de Stanchina E, Molina H, Victora GD, Goodarzi H, ... Birsoy K, et al. Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells. Cell Metabolism. PMID 33152324 DOI: 10.1016/j.cmet.2020.10.017  0.336
2020 Soula M, Weber RA, Zilka O, Alwaseem H, La K, Yen F, Molina H, Garcia-Bermudez J, Pratt DA, Birsoy K. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nature Chemical Biology. PMID 32778843 DOI: 10.1038/S41589-020-0613-Y  0.409
2020 Hedbacker K, Lu YH, Dallner O, Li Z, Fayzikhodjaeva G, Birsoy K, Han C, Yang C, Friedman JM. Limitation of adipose tissue by the number of embryonic progenitor cells. Elife. 9. PMID 32452759 DOI: 10.7554/Elife.53074  0.521
2020 Surface LE, Burrow DT, Li J, Park J, Kumar S, Lyu C, Song N, Yu Z, Rajagopal A, Bae Y, Lee BH, Mumm S, Gu CC, Baker JC, Mohseni M, ... ... Birsoy K, et al. regulates the action of nitrogen-containing bisphosphonates on bone. Science Translational Medicine. 12. PMID 32434850 DOI: 10.1126/Scitranslmed.Aav9166  0.506
2020 Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor J, Molina H, ... ... Birsoy K, et al. ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase. Cell Metabolism. 31: 852-861.e6. PMID 32268116 DOI: 10.1016/J.Cmet.2020.03.008  0.521
2020 Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K. Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation. Molecular Cell. PMID 31983508 DOI: 10.1016/J.Molcel.2020.01.003  0.71
2020 Hedbacker K, Lu Y, Dallner O, Li Z, Fayzikhodjaeva G, Birsoy K, Han C, Yang C, Friedman JM. Author response: Limitation of adipose tissue by the number of embryonic progenitor cells Elife. DOI: 10.7554/Elife.53074.Sa2  0.517
2019 Garcia-Bermudez J, Williams RT, Guarecuco R, Birsoy K. Targeting extracellular nutrient dependencies of cancer cells. Molecular Metabolism. PMID 31926876 DOI: 10.1016/J.Molmet.2019.11.011  0.433
2019 Weber R, Birsoy K. The Transsulfuration Pathway Makes, the Tumor Takes. Cell Metabolism. 30: 845-846. PMID 31693878 DOI: 10.1016/J.Cmet.2019.10.009  0.346
2019 Zhu XG, Birsoy K. Deciphering cellular heterogeneity of pancreatic tumours. Nature Cell Biology. 21: 1305-1306. PMID 31685993 DOI: 10.1038/S41556-019-0419-X  0.342
2019 Phillips RE, Yang Y, Smith RC, Thompson BM, Yamasaki T, Soto-Feliciano YM, Funato K, Liang Y, Garcia-Bermudez J, Wang X, Garcia BA, Yamasaki K, McDonald JG, Birsoy K, Tabar V, et al. Target identification reveals lanosterol synthase as a vulnerability in glioma. Proceedings of the National Academy of Sciences of the United States of America. PMID 30923116 DOI: 10.1073/Pnas.1820989116  0.346
2019 Birsoy K, Sancak Y. The role of metabolism in cellular processes. Molecular Biology of the Cell. 30: 733. PMID 30870095 DOI: 10.1091/Mbc.E19-01-0004  0.327
2019 Zhu XG, Nicholson Puthenveedu S, Shen Y, La K, Ozlu C, Wang T, Klompstra D, Gultekin Y, Chi J, Fidelin J, Peng T, Molina H, Hang HC, Min W, Birsoy K. CHP1 Regulates Compartmentalized Glycerolipid Synthesis by Activating GPAT4. Molecular Cell. PMID 30846317 DOI: 10.1016/J.Molcel.2019.01.037  0.388
2019 Dallner OS, Marinis JM, Lu YH, Birsoy K, Werner E, Fayzikhodjaeva G, Dill BD, Molina H, Moscati A, Kutalik Z, Marques-Vidal P, Kilpeläinen TO, Grarup N, Linneberg A, Zhang Y, et al. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity. Nature Medicine. PMID 30842678 DOI: 10.1038/S41591-019-0370-1  0.494
2019 Garcia-Bermudez J, Baudrier L, Bayraktar EC, Shen Y, La K, Guarecuco R, Yucel B, Fiore D, Tavora B, Freinkman E, Chan SH, Lewis C, Min W, Inghirami G, Sabatini DM, ... Birsoy K, et al. Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death. Nature. PMID 30760928 DOI: 10.1038/S41586-019-0945-5  0.597
2018 Bayraktar EC, Baudrier L, Özerdem C, Lewis CA, Chan SH, Kunchok T, Abu-Remaileh M, Cangelosi AL, Sabatini DM, Birsoy K, Chen WW. MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 30541894 DOI: 10.1073/Pnas.1816656115  0.751
2018 Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Publisher Correction: Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. PMID 30089842 DOI: 10.1038/S41556-018-0184-2  0.333
2018 Garcia-Bermudez J, Baudrier L, La K, Zhu XG, Fidelin J, Sviderskiy VO, Papagiannakopoulos T, Molina H, Snuderl M, Lewis CA, Possemato RL, Birsoy K. Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. Nature Cell Biology. PMID 29941933 DOI: 10.1038/S41556-018-0118-Z  0.431
2018 Zhang M, Di Martino JS, Bowman RL, Campbell NR, Baksh SC, Simon-Vermot T, Kim IS, Haldeman P, Mondal C, Yong-Gonzalez V, Abu-Akeel M, Merghoub T, Jones DR, Zhu XG, Arora A, ... ... Birsoy K, et al. Adipocyte-derived lipids mediate melanoma progression via FATP proteins. Cancer Discovery. PMID 29903879 DOI: 10.1158/2159-8290.Cd-17-1371  0.367
2018 Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, et al. Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers. Cell Reports. 23: 255-269.e4. PMID 29617665 DOI: 10.1016/J.Celrep.2018.03.077  0.392
2018 Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R. Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs. Molecular Cell. 69: 610-621.e5. PMID 29452640 DOI: 10.1016/J.Molcel.2018.01.024  0.574
2018 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato RL. Abstract NG02: NFS1 undergoes positive selection in lung tumors and protects cells from ferroptosis Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ng02  0.586
2017 Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. PMID 29168506 DOI: 10.1038/Nature24637  0.574
2017 Reczek CR, Birsoy K, Kong H, Martínez-Reyes I, Wang T, Gao P, Sabatini DM, Chandel NS. A CRISPR screen identifies a pathway required for paraquat-induced cell death. Nature Chemical Biology. PMID 29058724 DOI: 10.1038/Nchembio.2499  0.552
2017 Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, et al. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396387 DOI: 10.1073/Pnas.1617922114  0.773
2017 Secco B, Camiré É, Brière MA, Caron A, Billong A, Gélinas Y, Lemay AM, Tharp KM, Lee PL, Gobeil S, Guimond JV, Patey N, Guertin DA, Stahl A, Haddad É, ... ... Birsoy K, et al. Amplification of Adipogenic Commitment by VSTM2A. Cell Reports. 18: 93-106. PMID 28052263 DOI: 10.1016/J.Celrep.2016.12.015  0.661
2016 Garcia-Bermudez J, Birsoy K. Drugging ACAT1 for Cancer Therapy. Molecular Cell. 64: 856-857. PMID 27912096 DOI: 10.1016/J.Molcel.2016.11.023  0.303
2016 Chen WW, Freinkman E, Wang T, Birsoy K, Sabatini DM. Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism. Cell. 166: 1324-1337.e11. PMID 27565352 DOI: 10.1016/J.Cell.2016.07.040  0.559
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, et al. Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. 12: 656. PMID 27434767 DOI: 10.1038/Nchembio0816-656  0.678
2016 Chidley C, Trauger SA, Birsoy K, O'Shea EK. The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine. Elife. 5. PMID 27403889 DOI: 10.7554/Elife.14601  0.363
2016 Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu-Remaileh M, Shaul YD, et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology. PMID 27110680 DOI: 10.1038/Nchembio.2070  0.759
2015 Wang T, Birsoy K, Hughes NW, Krupczak KM, Post Y, Wei JJ, Lander ES, Sabatini DM. Identification and characterization of essential genes in the human genome. Science (New York, N.Y.). PMID 26472758 DOI: 10.1126/Science.Aac7041  0.554
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405]. Molecular Metabolism. 4: 592. PMID 26266092 DOI: 10.1016/J.Molmet.2015.05.004  0.459
2015 Birsoy K, Wang T, Chen WW, Freinkman E, Abu-Remaileh M, Sabatini DM. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 162: 540-551. PMID 26232224 DOI: 10.1016/J.Cell.2015.07.016  0.755
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression. Molecular Metabolism. 4: 392-405. PMID 25973387 DOI: 10.1016/J.Molmet.2015.02.002  0.505
2015 Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, et al. SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance. Nature. 520: 363-7. PMID 25855294 DOI: 10.1038/Nature14363  0.762
2015 Lu YH, Dallner OS, Birsoy K, Fayzikhodjaeva G, Friedman JM. Corrigendum to "Nuclear Factor-Y is an adipogenic factor that regulates leptin gene expression"[Mol Metab 4 (2015) 392-405] Molecular Metabolism. DOI: 10.1016/j.molmet.2015.05.004  0.387
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for mTORC1 in erythropoiesis and anemia. Elife. 3: e01913. PMID 25201874 DOI: 10.7554/Elife.01913  0.701
2014 Chen WW, Birsoy K, Mihaylova MM, Snitkin H, Stasinski I, Yucel B, Bayraktar EC, Carette JE, Clish CB, Brummelkamp TR, Sabatini DD, Sabatini DM. Inhibition of ATPIF1 ameliorates severe mitochondrial respiratory chain dysfunction in mammalian cells. Cell Reports. 7: 27-34. PMID 24685140 DOI: 10.1016/J.Celrep.2014.02.046  0.546
2014 Birsoy K, Possemato R, Lorbeer FK, Bayraktar EC, Thiru P, Yucel B, Wang T, Chen WW, Clish CB, Sabatini DM. Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 508: 108-12. PMID 24670634 DOI: 10.1038/Nature13110  0.601
2014 Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Cancer Discovery. 4: 554-63. PMID 24631838 DOI: 10.1158/2159-8290.CD-13-0929  0.608
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Lamming DA, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Science Signaling. 7: ra17. PMID 24550542 DOI: 10.1126/Scisignal.2004785  0.714
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. Author response: A critical role for mTORC1 in erythropoiesis and anemia Elife. DOI: 10.7554/Elife.01913.013  0.644
2014 Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. A correction to the research article titled: "The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism" (Science Signaling (2014)) Science Signaling. 7. DOI: 10.1126/scisignal.7315er2  0.466
2013 Birsoy K, Festuccia WT, Laplante M. A comparative perspective on lipid storage in animals. Journal of Cell Science. 126: 1541-52. PMID 23658371 DOI: 10.1242/Jcs.104992  0.644
2013 Birsoy K, Wang T, Possemato R, Yilmaz OH, Koch CE, Chen WW, Hutchins AW, Gultekin Y, Peterson TR, Carette JE, Brummelkamp TR, Clish CB, Sabatini DM. MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. Nature Genetics. 45: 104-8. PMID 23202129 DOI: 10.1038/Ng.2471  0.686
2012 Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 151: 1126-37. PMID 23178128 DOI: 10.1016/J.Cell.2012.10.039  0.658
2012 Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM. DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity. Cell Metabolism. 16: 202-12. PMID 22883231 DOI: 10.1016/J.Cmet.2012.07.008  0.711
2012 Birsoy K, Sabatini DM, Possemato R. Untuning the tumor metabolic machine: Targeting cancer metabolism: a bedside lesson. Nature Medicine. 18: 1022-3. PMID 22772555 DOI: 10.1038/Nm.2870  0.562
2012 Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 486: 490-5. PMID 22722868 DOI: 10.1038/Nature11163  0.691
2012 Ceyhan O, Birsoy K, Hoffman CS. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chemistry & Biology. 19: 155-63. PMID 22284362 DOI: 10.1016/J.Chembiol.2011.12.010  0.311
2011 Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development (Cambridge, England). 138: 4709-19. PMID 21989915 DOI: 10.1242/Jcs.101436  0.535
2011 Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, et al. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. Nature. 476: 346-50. PMID 21760589 DOI: 10.1038/Nature10350  0.748
2010 Chen W, Zhang X, Birsoy K, Roeder RG. A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 10196-201. PMID 20479251 DOI: 10.1073/Pnas.1005626107  0.509
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metabolism. 11: 11-22. PMID 20074524 DOI: 10.1016/J.Cmet.2009.11.007  0.503
2010 Hedbacker K, Birsoy K, Wysocki RW, Asilmaz E, Ahima RS, Farooqi IS, Friedman JM. Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene (DOI:10.1016/j.cmet.2009.11.007) Cell Metabolism. 11: 239. DOI: 10.1016/J.Cmet.2010.02.010  0.469
2008 Rodeheffer MS, Birsoy K, Friedman JM. Identification of white adipocyte progenitor cells in vivo. Cell. 135: 240-9. PMID 18835024 DOI: 10.1016/J.Cell.2008.09.036  0.532
2008 Birsoy K, Soukas A, Torrens J, Ceccarini G, Montez J, Maffei M, Cohen P, Fayzikhodjaeva G, Viale A, Socci ND, Friedman JM. Cellular program controlling the recovery of adipose tissue mass: An in vivo imaging approach. Proceedings of the National Academy of Sciences of the United States of America. 105: 12985-90. PMID 18753616 DOI: 10.1073/Pnas.0805621105  0.737
2008 Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metabolism. 7: 339-47. PMID 18396140 DOI: 10.1016/J.Cmet.2008.02.001  0.487
Low-probability matches (unlikely to be authored by this person)
2023 Kerk SA, Garcia-Bermudez J, Birsoy K, Sherman MH, Shah YM, Lyssiotis CA. Spotlight on GOT2 in Cancer Metabolism. Oncotargets and Therapy. 16: 695-702. PMID 37635751 DOI: 10.2147/OTT.S382161  0.298
2024 Timson RC, Khan A, Uygur B, Saad M, Yeh HW, DelGaudio N, Weber R, Alwaseem H, Gao J, Yang C, Birsoy K. A mouse model to study glutathione limitation . Biorxiv : the Preprint Server For Biology. PMID 38260639 DOI: 10.1101/2024.01.08.574722  0.288
2020 Bayraktar EC, La K, Karpman K, Unlu G, Ozerdem C, Ritter DJ, Alwaseem H, Molina H, Hoffmann HH, Millner A, Atilla-Gokcumen GE, Gamazon ER, Rushing AR, Knapik EW, Basu S, ... Birsoy K, et al. Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism. Nature Metabolism. 2: 487-498. PMID 32694732 DOI: 10.1038/s42255-020-0206-9  0.287
2020 Guarecuco R, Williams RT, Baudrier L, La K, Passarelli MC, Ekizoglu N, Mestanoglu M, Alwaseem H, Rostandy B, Fidelin J, Garcia-Bermudez J, Molina H, Birsoy K. Dietary thiamine influences l-asparaginase sensitivity in a subset of leukemia cells. Science Advances. 6. PMID 33036978 DOI: 10.1126/sciadv.abc7120  0.276
2023 Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K. Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Cell Metabolism. PMID 37100056 DOI: 10.1016/j.cmet.2023.04.003  0.276
2021 Rex MR, Williams R, Birsoy K, Ta Llman MS, Stahl M. Targeting mitochondrial metabolism in acute myeloid leukemia. Leukemia & Lymphoma. 1-8. PMID 34704521 DOI: 10.1080/10428194.2021.1992759  0.272
2021 Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW, Heissel S, Unlu G, Gamazon ER, Kharas MG, Hite R, ... Birsoy K, et al. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature. PMID 34707288 DOI: 10.1038/s41586-021-04025-w  0.265
2021 Liu Y, Birsoy K. Asparagine, a Key Metabolite in Cellular Response to Mitochondrial Dysfunction. Trends in Cancer. PMID 33896762 DOI: 10.1016/j.trecan.2021.04.001  0.253
2016 Chidley C, Trauger SA, Birsoy K, O'Shea EK. Author response: The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine Elife. DOI: 10.7554/Elife.14601.022  0.247
2023 Khan A, Unlu G, Lin P, Liu Y, Kilic E, Kenny TC, Birsoy K, Gamazon ER. GeneMAP: A discovery platform for metabolic gene function. Biorxiv : the Preprint Server For Biology. PMID 38106122 DOI: 10.1101/2023.12.07.570588  0.247
2023 Liu Y, Birsoy K. Metabolic sensing and control in mitochondria. Molecular Cell. 83: 877-889. PMID 36931256 DOI: 10.1016/j.molcel.2023.02.016  0.236
2023 Liu Y, Liu S, Tomar A, Yen FS, Unlu G, Ropek N, Weber RA, Wang Y, Khan A, Gad M, Peng J, Terzi E, Alwaseem H, Pagano AE, Heissel S, ... ... Birsoy K, et al. Autoregulatory control of mitochondrial glutathione homeostasis. Science (New York, N.Y.). 382: 820-828. PMID 37917749 DOI: 10.1126/science.adf4154  0.217
2023 Birsoy K, Chandel NS, Fendt SM, Green DR, Li X, Muoio DM. Challenges and opportunities in targeting metabolism. Cell Chemical Biology. 30: 999-1001. PMID 37738954 DOI: 10.1016/j.chembiol.2023.08.016  0.215
2020 Liberti MV, Birsoy K. A link between metabolic energetics and pancreatic cancer mechanosensing. Nature Metabolism. 2: 5-6. PMID 32694685 DOI: 10.1038/s42255-019-0165-1  0.208
2020 Liberti MV, Birsoy K. A link between metabolic energetics and pancreatic cancer mechanosensing Nature Metabolism. 2: 5-6. DOI: 10.1038/s42255-019-0165-1  0.208
2022 Unlu G, Prizer B, Erdal R, Yeh HW, Bayraktar EC, Birsoy K. Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Molecular Cell. 82: 3750. PMID 36206741 DOI: 10.1016/j.molcel.2022.09.004  0.195
2023 Son Y, Kenny TC, Khan A, Birsoy K, Hite RK. Structural basis of lipid head group entry to the Kennedy pathway by FLVCR1. Biorxiv : the Preprint Server For Biology. PMID 37808796 DOI: 10.1101/2023.09.28.560019  0.191
2022 Unlu G, Prizer B, Erdal R, Yeh HW, Bayraktar EC, Birsoy K. Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability. Molecular Cell. PMID 35714613 DOI: 10.1016/j.molcel.2022.05.024  0.183
2024 Gates LA, Reis BS, Lund PJ, Paul MR, Leboeuf M, Djomo AM, Nadeem Z, Lopes M, Vitorino FN, Unlu G, Carroll TS, Birsoy K, Garcia BA, Mucida D, Allis CD. Histone butyrylation in the mouse intestine is mediated by the microbiota and associated with regulation of gene expression. Nature Metabolism. PMID 38413806 DOI: 10.1038/s42255-024-00992-2  0.174
2021 Garcia-Bermudez J, Birsoy K. A mitochondrial gatekeeper that helps cells escape death by ferroptosis. Nature. 593: 514-515. PMID 33981062 DOI: 10.1038/d41586-021-01203-8  0.172
2005 Boyer-Guittaut M, Birsoy K, Potel C, Elliott G, Jaffray E, Desterro JM, Hay RT, Oelgeschläger T. SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5. The Journal of Biological Chemistry. 280: 9937-45. PMID 15637059 DOI: 10.1074/jbc.M414149200  0.141
2018 Dubard Gault M, Mandelker D, DeLair D, Stewart CR, Kemel Y, Sheehan MR, Siegel B, Kennedy J, Marcell V, Arnold A, Al-Ahmadie H, Modak S, Robson M, Shukla N, Roberts S, ... ... Birsoy K, et al. Germline mutations in children and adults with cancer. Cold Spring Harbor Molecular Case Studies. 4. PMID 30068732 DOI: 10.1101/mcs.a002584  0.139
2021 Birsoy K, Lessard SJ. Career pathways, part 5. Nature Metabolism. PMID 34099927 DOI: 10.1038/s42255-021-00413-8  0.127
2021 Soula M, Birsoy K. STACKing the odds for discoveries. Nature Chemical Biology. PMID 33686293 DOI: 10.1038/s41589-021-00743-4  0.036
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